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Aliases for ARL2BP Gene

Aliases for ARL2BP Gene

  • ADP-Ribosylation Factor-Like 2 Binding Protein 2 3
  • BART 3 4 6
  • Retinitis Pigmentosa 66 (Autosomal Recessive) 2 3
  • ARF-Like 2-Binding Protein 3 4
  • Binder Of ARF2 Protein 1 3 4
  • ARL2-Binding Protein 3 4
  • Binder Of Arl2 2 3
  • BART1 3 4
  • ADP-Ribosylation Factor-Like Protein 2-Binding Protein 3
  • Arf-Like 2 Binding Protein BART1 3
  • Binder Of Arl Two 3
  • RP66 3

External Ids for ARL2BP Gene

Previous HGNC Symbols for ARL2BP Gene

  • RP66

Previous GeneCards Identifiers for ARL2BP Gene

  • GC00U913737
  • GC16P057055
  • GC16P055836
  • GC16P043148

Summaries for ARL2BP Gene

Entrez Gene Summary for ARL2BP Gene

  • ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2 GTPase-activating protein activity. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL2BP Gene

ARL2BP (ADP-Ribosylation Factor-Like 2 Binding Protein) is a Protein Coding gene. Diseases associated with ARL2BP include retinitis pigmentosa with or without situs inversus and retinitis pigmentosa 66. GO annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot for ARL2BP Gene

  • Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL2BP Gene

Genomics for ARL2BP Gene

Regulatory Elements for ARL2BP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARL2BP Gene

57,245,098 bp from pter
57,253,635 bp from pter
8,538 bases
Plus strand

Genomic View for ARL2BP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL2BP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL2BP Gene

Proteins for ARL2BP Gene

  • Protein details for ARL2BP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 2-binding protein
    Protein Accession:
    Secondary Accessions:
    • B3KQJ5
    • Q504R0

    Protein attributes for ARL2BP Gene

    163 amino acids
    Molecular mass:
    18822 Da
    Quaternary structure:
    • Found in a complex with ARL2BP, ARL2 and SLC25A6. Found in a complex with ARL2, ARL2BP and SLC25A4. Interacts with STAT2, STAT3 and STAT4. Interacts with GTP-bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as ARL2BP alone, binds to ANT1. Interaction with ARL2 may be required for targeting to cilia basal body. Interacts with STAT3; interaction is enhanced with ARL2.

    Three dimensional structures from OCA and Proteopedia for ARL2BP Gene

    Alternative splice isoforms for ARL2BP Gene


neXtProt entry for ARL2BP Gene

Proteomics data for ARL2BP Gene at MOPED

Post-translational modifications for ARL2BP Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL2BP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ARL2BP Gene

Domains for ARL2BP Gene

Protein Domains for ARL2BP Gene


Suggested Antigen Peptide Sequences for ARL2BP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ARL2BP family.
  • Belongs to the ARL2BP family.
genes like me logo Genes that share domains with ARL2BP: view

No data available for Gene Families for ARL2BP Gene

Function for ARL2BP Gene

Molecular function for ARL2BP Gene

UniProtKB/Swiss-Prot Function:
Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2.

Gene Ontology (GO) - Molecular Function for ARL2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity IMP 18234692
GO:0005515 protein binding IPI 11847227
GO:0030695 GTPase regulator activity TAS 10488091
genes like me logo Genes that share ontologies with ARL2BP: view

Animal Model Products

CRISPR Products

miRNA for ARL2BP Gene

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARL2BP Gene

Localization for ARL2BP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL2BP Gene

Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal body. Note=The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. In retina photoreceptor cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet. Interaction with ARL2 may be required for cilia basal body localization. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for ARL2BP Gene COMPARTMENTS Subcellular localization image for ARL2BP gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARL2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005758 mitochondrial intermembrane space IDA 11809823
GO:0005759 mitochondrial matrix TAS --
GO:0005813 centrosome IDA 16525022
genes like me logo Genes that share ontologies with ARL2BP: view

Pathways for ARL2BP Gene

SuperPathways for ARL2BP Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL2BP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007165 signal transduction TAS 10488091
GO:0042517 positive regulation of tyrosine phosphorylation of Stat3 protein IMP 18234692
GO:0044281 small molecule metabolic process TAS --
GO:0050790 regulation of catalytic activity TAS 10488091
genes like me logo Genes that share ontologies with ARL2BP: view

No data available for Pathways by source for ARL2BP Gene

Compounds for ARL2BP Gene

(1) HMDB Compounds for ARL2BP Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with ARL2BP: view

Transcripts for ARL2BP Gene

Unigene Clusters for ARL2BP Gene

ADP-ribosylation factor-like 2 binding protein:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARL2BP Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: -
SP2: - -
SP3: - -
SP4: - - - -
SP5: - - - - -

Relevant External Links for ARL2BP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL2BP Gene

mRNA expression in normal human tissues for ARL2BP Gene

Protein differential expression in normal tissues for ARL2BP Gene

This gene is overexpressed in Bone (11.3), Tlymphocyte (9.4), and Ovary (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARL2BP Gene

SOURCE GeneReport for Unigene cluster for ARL2BP Gene Hs.719024

mRNA Expression by UniProt/SwissProt for ARL2BP Gene

Tissue specificity: Expressed in retina pigment epithelial cells (at protein level). Widely expressed.
genes like me logo Genes that share expressions with ARL2BP: view

Expression partners for ARL2BP Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARL2BP Gene

Orthologs for ARL2BP Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL2BP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARL2BP 35
  • 91.36 (n)
  • 96.3 (a)
  • 96 (a)
(Canis familiaris)
Mammalia ARL2BP 35
  • 91.56 (n)
  • 95.68 (a)
  • 95 (a)
(Mus musculus)
Mammalia Arl2bp 35
  • 88.14 (n)
  • 95.71 (a)
Arl2bp 16
Arl2bp 36
  • 96 (a)
(Pan troglodytes)
Mammalia ARL2BP 35
  • 99.8 (n)
  • 100 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Arl2bp 35
  • 85.75 (n)
  • 94.66 (a)
(Monodelphis domestica)
Mammalia ARL2BP 36
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
-- 36
  • 87 (a)
(Gallus gallus)
Aves ARL2BP 35
  • 77.53 (n)
  • 83.7 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia ARL2BP 36
  • 80 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl2bp 35
  • 69.85 (n)
  • 74.52 (a)
(Danio rerio)
Actinopterygii arl2bp 35
  • 69.68 (n)
  • 70.32 (a)
arl2bp 36
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012967 35
  • 55.38 (n)
  • 47.69 (a)
Species with no ortholog for ARL2BP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL2BP Gene

Gene Tree for ARL2BP (if available)
Gene Tree for ARL2BP (if available)

Paralogs for ARL2BP Gene

genes like me logo Genes that share paralogs with ARL2BP: view

No data available for Paralogs for ARL2BP Gene

Variants for ARL2BP Gene

Sequence variations from dbSNP and Humsavar for ARL2BP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs9843 -- 57,253,077(+) GTGAA(A/G)GCAAA utr-variant-3-prime
rs14980 -- 57,253,421(-) TCTTC(A/G/T)TTCTA utr-variant-3-prime
rs14981 -- 57,253,550(-) AAACA(A/C)AGAGC utr-variant-3-prime
rs889556 -- 57,243,284(+) CTTTT(A/T)AAATG upstream-variant-2KB
rs1044196 -- 57,252,299(+) TCATT(C/T)TGGAT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARL2BP Gene

Variant ID Type Subtype PubMed ID
nsv509621 CNV Insertion 20534489
esv9721 CNV Gain 19470904

Relevant External Links for ARL2BP Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL2BP Gene

Disorders for ARL2BP Gene

(1) OMIM Diseases for ARL2BP Gene (615407)


  • Retinitis pigmentosa with or without situs inversus (RPSI) [MIM:615434]: A disorder characterized by variable association of retinitis pigmentosa with situs inversus. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Situs inversus is a congenital abnormality in which organs in the thorax and the abdomen are opposite to their normal positions due to lateral transposition. {ECO:0000269 PubMed:23849777}. Note=The disease is caused by mutations affecting the gene represented in this entry.
genes like me logo Genes that share disorders with ARL2BP: view

No data available for University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ARL2BP Gene

Publications for ARL2BP Gene

  1. The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization. (PMID: 10488091) Sharer J.D. … Kahn R.A. (J. Biol. Chem. 1999) 2 3 4
  2. The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function. (PMID: 18981177) Bailey L.K. … Mott H.R. (J. Biol. Chem. 2009) 2 3 4
  3. Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa. (PMID: 23849777) Davidson A.E. … Webster A.R. (Am. J. Hum. Genet. 2013) 2 3 4
  4. Arl2 and Arl3 regulate different microtubule-dependent processes. (PMID: 16525022) Zhou C. … Kahn R.A. (Mol. Biol. Cell 2006) 3 4
  5. BART is essential for nuclear retention of STAT3. (PMID: 18234692) Muromoto R. … Matsuda T. (Int. Immunol. 2008) 3 4

Products for ARL2BP Gene

Sources for ARL2BP Gene

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