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ARL2BP Gene

protein-coding   GIFtS: 49
GCID: GC16P057279

ADP-Ribosylation Factor-Like 2 Binding Protein

(Previous name: retinitis pigmentosa 66 (autosomal recessive))
(Previous symbol: RP66)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 2 Binding Protein1 2     BART12 3
BART2 3 5     ARF-Like 2-Binding Protein2 3
RP661 2     ARL2-Binding Protein2 3
Retinitis Pigmentosa 66 (Autosomal Recessive)1 2     ADP-Ribosylation Factor-Like Protein 2-Binding Protein2
Binder Of Arl21 2     Arf-Like 2 Binding Protein BART12
Binder Of ARF2 Protein 12 3     Binder Of Arl Two2

External Ids:    HGNC: 171461   Entrez Gene: 235682   Ensembl: ENSG000001029317   OMIM: 6154075   UniProtKB: Q9Y2Y03   

Export aliases for ARL2BP gene to outside databases

Previous GC identifers: GC00U913737 GC16P057055 GC16P055836 GC16P043148


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARL2BP Gene:
ADP-ribosylation factor (ARF)-like proteins (ARLs) comprise a functionally distinct group of the ARF family of
RAS-related GTPases. The protein encoded by this gene binds to ARL2.GTP with high affinity but does not interact
with ARL2.GDP, activated ARF, or RHO proteins. The lack of detectable membrane association of this protein or
ARL2 upon activation of ARL2 is suggestive of actions distinct from those of the ARFs. This protein is considered
to be the first ARL2-specific effector identified, due to its interaction with ARL2.GTP but lack of ARL2
GTPase-activating protein activity. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARL2BP Gene:
ARL2BP (ADP-ribosylation factor-like 2 binding protein) is a protein-coding gene. Diseases associated with ARL2BP include retinitis pigmentosa with or without situs inversus, and retinitis pigmentosa 2. GO annotations related to this gene include transcription coactivator activity and small GTPase regulator activity.

UniProtKB/Swiss-Prot: AR2BP_HUMAN, Q9Y2Y0
Function: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of
STAT3. May play a role as an effector of ARL2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the ARL2BP gene promoter:
         Pbx1a   AML1a   MyoD   MIF-1   Tal-1beta   POU3F2   YY1   HFH-1   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL2BP promoter sequence
   Search Chromatin IP Primers for ARL2BP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL2BP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

ARL2BP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL2BP gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P057279:  view genomic region     (about GC identifiers)

Start:
57,279,010 bp from pter      End:
57,287,545 bp from pter
Size:
8,536 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: AR2BP_HUMAN, Q9Y2Y0 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 2-binding protein  
Size: 163 amino acids; 18822 Da
Subunit: Found in a complex with ARL2BP, ARL2 and SLC25A6. Found in a complex with ARL2, ARL2BP and SLC25A4.
Interacts with STAT2, STAT3 and STAT4. Interacts with GTP-bound ARL2 and ARL3; the complex ARL2-ARL2BP as well as
ARL2BP alone, binds to ANT1. Interaction with ARL2 may be required for targeting to cilia basal body. Interacts
with STAT3; interaction is enhanced with ARL2
3 PDB 3D structures from and Proteopedia for ARL2BP:
2K9A (3D)        3DOE (3D)        3DOF (3D)    
Secondary accessions: B3KQJ5 Q504R0
Alternative splicing: 2 isoforms:  Q9Y2Y0-1   Q9Y2Y0-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARL2BP: NX_Q9Y2Y0

Explore proteomics data for ARL2BP at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARL2BP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_036238.1  
    ENSEMBL proteins: 
     ENSP00000219204   ENSP00000457465   ENSP00000454237  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR023379 ARF-like_2-bdp_dom

    Graphical View of Domain Structure for InterPro Entry Q9Y2Y0

    ProtoNet protein and cluster: Q9Y2Y0

    UniProtKB/Swiss-Prot: AR2BP_HUMAN, Q9Y2Y0
    Similarity: Belongs to the ARL2BP family


    ARL2BP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: AR2BP_HUMAN, Q9Y2Y0
    Function: Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of
    STAT3. May play a role as an effector of ARL2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity IMP18234692
    GO:0005083small GTPase regulator activity TAS10488091
    GO:0005515protein binding IPI11847227
         
    ARL2BP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL2BP
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    miRNA
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    miRTarBase miRNAs that target ARL2BP:
    hsa-mir-375 (MIRT020015), hsa-mir-192-5p (MIRT026813), hsa-mir-16-5p (MIRT051112), hsa-mir-215-5p (MIRT024907)

    Block miRNA regulation of human, mouse, rat ARL2BP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL2BP (see all 14):
    hsa-miR-3163 hsa-miR-485-5p hsa-miR-429 hsa-miR-374b hsa-miR-496 hsa-miR-374a hsa-miR-548aa hsa-miR-200c
    SwitchGear 3'UTR luciferase reporter plasmidARL2BP 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    AR2BP_HUMAN, Q9Y2Y0: Cytoplasm. Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule
    organizing center, centrosome. Nucleus. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, cilium basal
    body. Note=The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity).
    Detected in the midbody matrix. Not detected in the Golgi, nucleus and on the mitotic spindle.
    Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. In retina photoreceptor
    cells, localized in the distal connecting cilia, basal body, ciliary-associated centriole, and ciliary rootlet.
    Interaction with ARL2 may be required for cilia basal body localization
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    mitochondrion5
    nucleus5
    cytosol2
    extracellular1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005758mitochondrial intermembrane space IDA11809823
    GO:0005813centrosome IDA16525022
    GO:0005819spindle IEA--

    ARL2BP for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL2BP
    Interactions:

        Search GeneGlobe Interaction Network for ARL2BP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for ARL2BP (Q9Y2Y03 ENSP000002192044) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARL2P364043, ENSP000002467474I2D: score=3 STRING: ENSP00000246747
    ARL3P364053, ENSP000002607464I2D: score=3 STRING: ENSP00000260746
    RAC1P630003, ENSP000003484614I2D: score=3 STRING: ENSP00000348461
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    CAMK2DENSP000003397404STRING: ENSP00000339740
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS10488091
    GO:0042517positive regulation of tyrosine phosphorylation of Stat3 protein IMP18234692
    GO:0050790regulation of catalytic activity TAS10488091
    GO:0051457maintenance of protein location in nucleus IMP18234692
    GO:2001141regulation of RNA biosynthetic process IMP18234692

    ARL2BP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL2BP (AR2BP)

    1 HMDB Compound for ARL2BP    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARL2BP gene: 
    NM_012106.3  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000219204(uc010ccy.1 uc010vhl.2 uc002elf.1) ENST00000565794
    ENST00000562023 ENST00000563234
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARL2BP (see all 14):
    hsa-miR-3163 hsa-miR-485-5p hsa-miR-429 hsa-miR-374b hsa-miR-496 hsa-miR-374a hsa-miR-548aa hsa-miR-200c
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      QuantiTect SYBR Green Assays in human, mouse, rat ARL2BP
      QuantiFast Probe-based Assays in human, mouse, rat ARL2BP

    Selected AceView cDNA sequences (see all 348):

    BE044354 NM_012106 AK075050 AW130200 BM924617 AW628897 AA594913 AW591051 
    BQ072317 T61689 BC003087 BF940026 AA100215 BQ772966 AA770416 BM312227 
    BP380052 BP371811 AI096743 AL702489 AU280281 AA148503 CF130653 AA447844 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for ARL2BP    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c · 6d · 6e · 6f
    SP1:                    -                                                                                       
    SP2:                    -                                                     -                                 
    SP3:                    -                                   -                                                   
    SP4:                    -           -     -     -                                                               
    SP5:                                      -     -     -     -     -                                             


    ECgene alternative splicing isoforms for ARL2BP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL2BP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTAAAACTT
    ARL2BP Expression
    About this image

    ARL2BP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL2BP Protein Expression

    UniProtKB/Swiss-Prot: AR2BP_HUMAN, Q9Y2Y0
    Tissue specificity: Expressed in retina pigment epithelial cells (at protein level). Widely expressed

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARL2BP gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl2bp1 , 5 ADP-ribosylation factor-like 2 binding protein1, 5 88.14(n)1
    95.71(a)1
      8 (46.65 cM)5
    1075661  NM_024191.21  NP_077153.11 
     946667555 
    chicken
    (Gallus gallus)
    Aves ARL2BP1 ADP-ribosylation factor-like 2 binding protein 77.53(n)
    83.7(a)
      426495  NM_001007970.1  NP_001007971.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL2BP6
    ADP-ribosylation factor-like 2 binding protein
    80(a)
    1 ↔ 1
    GL343677.1(220197-231193)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arl2bp1 ADP-ribosylation factor-like 2 binding protein 69.85(n)
    74.52(a)
      549774  NM_001017020.2  NP_001017020.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arl2bp1 ADP-ribosylation factor-like 2 binding protein 69.68(n)
    70.32(a)
      393976  NM_201001.2  NP_957295.2 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0129671 AgaP_AGAP012967 55.38(n)
    47.69(a)
      11175764  XM_003436436.1  XP_003436484.1 


    ENSEMBL Gene Tree for ARL2BP (if available)
    TreeFam Gene Tree for ARL2BP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL2BP gene

    ARL2BP for paralogs           About GeneDecksing


    Selected Pseudogenes.org Pseudogenes for ARL2BP (see all 11)
    PGOHUM00000239787 PGOHUM00000248568 PGOHUM00000246916 PGOHUM00000237111 PGOHUM00000237189


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL2BP (see all 234)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0702274
    Retinitis pigmentosa with or without situs inversus (RPSI)4--see VAR_0702272 M R mis40--------
    rs8895561,2
    C,F,A,H--57277196(+) CTTTTA/TAAATG 1 -- us2k114Minor allele frequency- T:0.01NS EA NA WA CSA 554
    rs1486622721,2
    --57277222(+) GTGCTA/GAACAG 1 -- us2k10--------
    rs1815379271,2
    --57277254(+) CCTGAC/GCGGGT 1 -- us2k10--------
    rs1874606671,2
    --57277401(+) TGGTGA/GCACGC 1 -- us2k10--------
    rs1919109771,2
    --57277561(+) AGTGGC/TTCACG 1 -- us2k10--------
    rs1823971091,2
    --57277585(+) CACTTC/TGGGAG 1 -- us2k10--------
    rs1510574671,2
    C--57277618(+) AGGTCA/GGGAGT 1 -- us2k10--------
    rs20083171,2
    C,F,H--57277748(+) ttgaaC/Accggt 1 -- us2k16Minor allele frequency- A:0.18NA WA CSA 11
    rs1867841261,2
    --57277821(+) AACTCA/CATCTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARL2BP (57279010 - 57287545 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARL2BP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509621CNV Insertion20534489
    esv9721CNV Gain19470904

    Human Gene Mutation Database (HGMD): ARL2BP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL2BP
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615407   
    OMIM disorders: 615434  
    UniProtKB/Swiss-Prot: AR2BP_HUMAN, Q9Y2Y0
  • Retinitis pigmentosa with or without situs inversus (RPSI) [MIM:615434]: A disorder characterized by
    variable association of retinitis pigmentosa with situs inversus. Retinitis pigmentosa is characterized by
    retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by
    secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral
    visual field. As their condition progresses, they lose their far peripheral visual field and eventually central
    vision as well. Situs inversus is a congenital abnormality in which organs in the thorax and the abdomen are
    opposite to their normal positions due to lateral transposition. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 9 diseases for ARL2BP:    
    About MalaCards
    retinitis pigmentosa with or without situs inversus    retinitis pigmentosa 2    leber congenital amaurosis    retinitis pigmentosa
    retinitis    pancreatic cancer    nasopharyngitis    pancreatitis
    malaria


    ARL2BP for disorders           About GeneDecksing


    Export disorders for ARL2BP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL2BP gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ARL2BP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in ARL2BP, encoding ADP-ribosylation-factor-like 2 binding protein, cause autosomal-recessive retinitis pigmentosa. (PubMed id 23849777)1, 2, 3 Davidson A.E....Webster A.R. (Am. J. Hum. Genet. 2013)
    2. The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function. (PubMed id 18981177)1, 2, 3 Bailey L.K.... Mott H.R. (J. Biol. Chem. 2009)
    3. The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization. (PubMed id 10488091)1, 2, 3 Sharer J.D. and Kahn R.A. (J. Biol. Chem. 1999)
    4. Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector. (PubMed id 19368893)1, 2 Zhang T.... Ding J. (Structure 2009)
    5. BART is essential for nuclear retention of STAT3. (PubMed id 18234692)1, 2 Muromoto R....Matsuda T. (Int. Immunol. 2008)
    6. Arl2 and Arl3 regulate different microtubule-dependent processes. (PubMed id 16525022)1, 2 Zhou C.... Kahn R.A. (Mol. Biol. Cell 2006)
    7. Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. (PubMed id 11847227)1, 2 Bartolini F....Cowan N.J. (J. Biol. Chem. 2002)
    8. ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter. (PubMed id 11809823)1, 2 Sharer J.D.... Kahn R.A. (Mol. Biol. Cell 2002)
    9. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PubMed id 11303027)1, 2 Van Valkenburgh H.... Kahn R.A. (J. Biol. Chem. 2001)
    10. EBV-miR-BART1 is involved in regulating metabolism-associated genes in nasopharyngeal carcinoma. (PubMed id 23685147)1 Ye Y....Li X. (Biochem. Biophys. Res. Commun. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23568 HGNC: 17146 AceView: ARL2BP Ensembl:ENSG00000102931 euGenes: HUgn23568
    ECgene: ARL2BP H-InvDB: ARL2BP

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARL2BP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARL2BP gene:
    Search GeneIP for patents involving ARL2BP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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