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Aliases for ARL2 Gene

Aliases for ARL2 Gene

  • ADP-Ribosylation Factor-Like 2 2 3
  • ADP-Ribosylation Factor-Like Protein 2 3
  • ARFL2 3

External Ids for ARL2 Gene

Previous GeneCards Identifiers for ARL2 Gene

  • GC11P067297
  • GC11U900036
  • GC11P064558
  • GC11P064559
  • GC11P064539
  • GC11P064781
  • GC11P061108

Summaries for ARL2 Gene

Entrez Gene Summary for ARL2 Gene

  • This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL2 Gene

ARL2 (ADP-Ribosylation Factor-Like 2) is a Protein Coding gene. Diseases associated with ARL2 include retinitis pigmentosa 2 and retinitis pigmentosa. GO annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARL2 Gene

  • Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.

Gene Wiki entry for ARL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL2 Gene

Genomics for ARL2 Gene

Regulatory Elements for ARL2 Gene

Genomic Location for ARL2 Gene

Start:
65,014,113 bp from pter
End:
65,022,185 bp from pter
Size:
8,073 bases
Orientation:
Plus strand

Genomic View for ARL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL2 Gene

Proteins for ARL2 Gene

  • Protein details for ARL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36404-ARL2_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 2
    Protein Accession:
    P36404
    Secondary Accessions:
    • G3V184
    • Q9BUK8

    Protein attributes for ARL2 Gene

    Size:
    184 amino acids
    Molecular mass:
    20878 Da
    Quaternary structure:
    • Found in a complex with ARL2, ARL2BP and SLC25A6. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Found in a complex with ARL2, ARL2BP and SLC25A4. The GTP-bound form interacts with PDE6D. Interacts with ELMOD2. The GTP-bound form interacts with ARL2BP. Interacts, preferentially in its GDP-bound state, with TBCD. Interacts with UNC119.

    Three dimensional structures from OCA and Proteopedia for ARL2 Gene

    Alternative splice isoforms for ARL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL2 Gene

Proteomics data for ARL2 Gene at MOPED

Post-translational modifications for ARL2 Gene

Other Protein References for ARL2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ARL2 Gene

Domains for ARL2 Gene

Gene Families for ARL2 Gene

HGNC:
  • ARF :ADP-ribosylation factors
  • ARL :ADP-ribosylation factors-like

Protein Domains for ARL2 Gene

Suggested Antigen Peptide Sequences for ARL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36404

UniProtKB/Swiss-Prot:

ARL2_HUMAN :
  • P36404
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL2: view

Function for ARL2 Gene

Molecular function for ARL2 Gene

GENATLAS Biochemistry:
ADP-ribosylation factor-like 2,low molecular weight GTP binding protein,widely expressed,Ras superfamily member
UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.

Gene Ontology (GO) - Molecular Function for ARL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IMP 10831612
GO:0004871 signal transducer activity --
GO:0005095 GTPase inhibitor activity TAS 10831612
GO:0005515 protein binding IPI 10831612
GO:0005525 GTP binding IMP 10831612
genes like me logo Genes that share ontologies with ARL2: view

Phenotypes for ARL2 Gene

GenomeRNAi human phenotypes for ARL2:
genes like me logo Genes that share phenotypes with ARL2: view

Animal Model Products

miRNA for ARL2 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARL2 Gene

Localization for ARL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL2 Gene

Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL2 Gene COMPARTMENTS Subcellular localization image for ARL2 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 5
nucleus 5
plasma membrane 4
cytosol 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for ARL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 18234692
GO:0005737 cytoplasm --
GO:0005758 mitochondrial intermembrane space IDA 11809823
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with ARL2: view

Pathways for ARL2 Gene

SuperPathways for ARL2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0007021 tubulin complex assembly TAS 10831612
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with ARL2: view

No data available for Pathways by source for ARL2 Gene

Compounds for ARL2 Gene

(2) Novoseek inferred chemical compound relationships for ARL2 Gene

Compound -log(P) Hits PubMed IDs
adp 58.7 8
gtp 34.6 2
genes like me logo Genes that share compounds with ARL2: view

Transcripts for ARL2 Gene

Unigene Clusters for ARL2 Gene

ADP-ribosylation factor-like 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL2 Gene

No ASD Table

Relevant External Links for ARL2 Gene

GeneLoc Exon Structure for
ARL2
ECgene alternative splicing isoforms for
ARL2

Expression for ARL2 Gene

mRNA expression in normal human tissues for ARL2 Gene

Protein differential expression in normal tissues for ARL2 Gene

This gene is overexpressed in Bone (24.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL2 Gene

SOURCE GeneReport for Unigene cluster for ARL2 Gene Hs.502836

genes like me logo Genes that share expressions with ARL2: view

Expression partners for ARL2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARL2 Gene

Orthologs for ARL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARL2 35
  • 93.84 (n)
  • 98.37 (a)
ARL2 36
  • 98 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ARL2 35
  • 92.75 (n)
  • 98.91 (a)
mouse
(Mus musculus)
Mammalia Arl2 35
  • 90.76 (n)
  • 96.2 (a)
Arl2 16
Arl2 36
  • 96 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia ARL2 35
  • 95.65 (n)
  • 94.57 (a)
rat
(Rattus norvegicus)
Mammalia Arl2 35
  • 90.04 (n)
  • 95.11 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arl2 35
  • 75.91 (n)
  • 89.67 (a)
MGC75676 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.11505 35
zebrafish
(Danio rerio)
Actinopterygii arl2 35
  • 71.38 (n)
  • 84.78 (a)
Dr.13768 35
arl2 36
  • 85 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1138 35
fruit fly
(Drosophila melanogaster)
Insecta Arf84F 37
  • 75 (a)
Arf84F 35
  • 67.03 (n)
  • 75.54 (a)
Arf84F 36
  • 76 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005267 35
  • 70.65 (n)
  • 72.83 (a)
worm
(Caenorhabditis elegans)
Secernentea evl-20 37
  • 61 (a)
evl-20 35
  • 56.7 (n)
  • 62.5 (a)
evl-20 36
  • 63 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CIN4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TTN5 35
  • 61.96 (n)
  • 64.67 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4477 35
rice
(Oryza sativa)
Liliopsida Os.11794 35
Os02g0327100 35
  • 65.02 (n)
  • 64.29 (a)
corn
(Zea mays)
Liliopsida Zm.12954 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1357 35
bread mold
(Neurospora crassa)
Ascomycetes NCU00218 35
  • 62.57 (n)
  • 63.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alp41 35
  • 49.05 (n)
  • 55.11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2707 36
  • 80 (a)
OneToMany
Species with no ortholog for ARL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL2 Gene

ENSEMBL:
Gene Tree for ARL2 (if available)
TreeFam:
Gene Tree for ARL2 (if available)

Paralogs for ARL2 Gene

Selected SIMAP similar genes for ARL2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ARL2 Gene

genes like me logo Genes that share paralogs with ARL2: view

Variants for ARL2 Gene

Sequence variations from dbSNP and Humsavar for ARL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_028056 -

Structural Variations from Database of Genomic Variants (DGV) for ARL2 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
dgv1174n71 CNV Loss 21882294

Relevant External Links for ARL2 Gene

HapMap Linkage Disequilibrium report
ARL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL2 Gene

Disorders for ARL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for ARL2 Gene in MalaCards »

(2) Diseases for ARL2 Gene including...

genes like me logo Genes that share disorders with ARL2: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ARL2 Gene

Publications for ARL2 Gene

  1. ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter. (PMID: 11809823) Sharer J.D. … Kahn R.A. (Mol. Biol. Cell 2002) 3 4 23
  2. ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. (PMID: 10831612) Bhamidipati A. … Cowan N.J. (J. Cell Biol. 2000) 3 4 23
  3. Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF- like genes. (PMID: 8415637) Clark J. … Kahn R.A. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4
  4. A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. (PMID: 9253601) Guru S.C. … Chandrasekharappa S.C. (Genome Res. 1997) 2 3
  5. Functional overlap between retinitis pigmentosa 2 protein and the tubulin-specific chaperone cofactor C. (PMID: 11847227) Bartolini F. … Cowan N.J. (J. Biol. Chem. 2002) 3 4

Products for ARL2 Gene

Sources for ARL2 Gene

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