ARL2 Gene
protein-coding GIFtS: 53
GCID: GC11P064781
|
|
ADP-ribosylation factor-like 2
| |
Aliases for ARL2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| ADP-Ribosylation Factor-Like 21 2 | | ARFL21 2 | | ADP-Ribosylation Factor-Like Protein 22 |
Export aliases for ARL2 gene to outside databasesPrevious GC identifers: GC11P067297 GC11U900036 GC11P064558 GC11P064559 GC11P064539 GC11P061108 |
Summaries for ARL2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for ARL2: This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor(ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: ARL2_HUMAN, P36404Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and therate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulatesformation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction.Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect ofTBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role inthe nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathwayinvolved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle Gene Wiki entry for ARL2
|
Genomic Views for ARL2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the ARL2 gene promoter: RFX1 Tal-1 p53 MAZR Brachyury Egr-1 POU3F2 Egr-4 E47 ATF6 Other transcription factors
Search SABiosciences Chromatin IP Primers for ARL2
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL2 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13ARL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P064781: view genomic region
(about GC identifiers)
Start:
|
64,781,585 bp from pter |
End:
|
64,789,656 bp from pter |
Size:
|
8,072 bases |
Orientation:
|
plus strand |
|
Proteins for ARL2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: ARL2_HUMAN, P36404 (See
protein sequence)Recommended Name: ADP-ribosylation factor-like protein 2 Size: 184 amino acids; 20878 Da
Subunit: Found in a complex with ARL2, ARL2BP and SLC25A6. Found in a complex with at least ARL2, PPP2CB, PPP2R1A,PPP2R2A, PPP2R5E and TBCD. Found in a complex with ARL2, ARL2BP and SLC25A4. The GTP-bound form interacts with PDE6D.Interacts with ELMOD2. The GTP-bound form interacts with ARL2BP. Interacts, preferentially in its GDP-bound state,with TBCD. Interacts with UNC119
Subcellular location: Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, centrosome. Nucleus. Cytoplasm.Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP,ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitoticspindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules
2 PDB 3D structures from and Proteopedia for ARL2:3DOE (3D)
  3DOF (3D)
 
Secondary accessions: Q9BUK8Explore the universe of human proteins at neXtProt for ARL2: NX_P36404
Post-translational modifications:
Not N-myristoylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P36404 ARL2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001186674.1 NP_001658.2 ENSEMBL proteins: ENSP00000246747 ENSP00000436021 ENSP00000432971 Human Recombinant Protein Products:
Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table
ARL2 for ontologies About GeneDecksing
ARL2 Antibody Products: Assay Products for ARL2: |
Protein
Domains / Families for ARL2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARL2 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P36404ProtoNet protein and cluster: P36404 1 Blocks protein family: IPB006688 ADP-ribosylation factor
UniProtKB/Swiss-Prot: ARL2_HUMAN, P36404Similarity: Belongs to the small GTPase superfamily. Arf family |
Function for ARL2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: ARL2_HUMAN, P36404Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and therate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP).GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulatesformation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction.Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect ofTBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role inthe nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathwayinvolved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle Genatlas biochemistry entry for ARL2:ADP-ribosylation factor-like 2,low molecular weight GTP binding protein,widely expressed,Ras superfamily member
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ARL2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ARL2:
|
Pathways & Interactions for ARL2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARL2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
 5/19 Interacting proteins for ARL2 (P364042, 3 ENSP000002467474) via UniProtKB, MINT, STRING, and/or I2D (see all 19)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
ARL2 for ontologies About GeneDecksing
|
Drugs & Compounds for ARL2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ARL2 for compounds About GeneDecksing
Browse Tocris compounds for ARL2 2 Novoseek chemical compound relationships for ARL2 gene About this table
Search CenterWatch for drugs/clinical trials and news about ARL2 
|
Transcripts for ARL2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for ARL2 gene (2 alternative transcripts): NM_001199745.1 NM_001667.3 Unigene Cluster for ARL2: ADP-ribosylation factor-like 2 Hs.502836 [show with all ESTs]Unigene Representative Sequence: FY2126536 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000246747(uc001och.4 uc021qlc.1) ENST00000524585(uc010rnu.2) ENST00000529384 ENST00000533729 ENST00000531533 ENST00000529254
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL2 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ARL2 (NM_001667) | |  | DNA2.0 Custom Codon Optimized Gene
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Additional cDNA sequence: AF493888.1 AK223502.1 AK294580.1 BC002530.2 BT006674.1 L13687.1 10 DOTS entries: DT.446007 DT.100828285 DT.113150 DT.40189101 DT.92433250 DT.95251277 DT.95070897 DT.95251280 DT.75179506 DT.95296513 24/324 AceView cDNA sequences (see all 324): T29292 NM_147777 BC002530 BU730115 AW190262 BM695030 BE279801 BQ957603 BQ691172 CB109435 AJ346501 AW297877 CR595019 BC012767 BE140389 CB156380 AA333945 BM853836 AA325070 NM_013306 CR614003 BX111746 AI631767 BC014520 GeneLoc Exon Structure
|
Expression for ARL2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARL2 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: GCGGGAGGGC
About this image See ARL2 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for ARL2
SOURCE GeneReport for Unigene cluster: Hs.502836 SABiosciences Custom PCR Arrays for ARL2
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL2 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARL2 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL2 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL2 |
Orthologs for ARL2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ARL2 gene from 7/36 species (see all 36) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
lizard (Anolis carolinensis) |
Reptilia |
ARL26 |
-- |
89(a) |
1 ↔ 1 |
GL344077.1(69729-74354) |
African clawed frog (Xenopus laevis) |
Amphibia |
Xl.115052 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.58(n) |
  |
BX853277.1 |
zebrafish (Danio rerio) |
Actinopterygii |
Dr.137682 |
Transcribed sequence with moderate similarity to protein more |
73.69(n) |
  |
CK352276.1 |
fruit fly (Drosophila melanogaster) |
Insecta |
Arf84F1 , 3 |
protein amino acid ADP-ribosylation GTP binding3 ADP ribosylation factor 84F1 |
75(a)3 67.03(n)1 75.54(a)1 |
  |
84F133 409931 NM_057538.31 NP_476886.11 |
worm (Caenorhabditis elegans) |
Secernentea |
evl-201 , 3 |
GTP-binding ADP-ribosylation factor3 Protein EVL-201 |
61(a)3 56.7(n)1 62.5(a)1 |
  |
II(8444128-8445068)3 1916321 NM_063378.11 NP_495779.11 |
thale cress (Arabidopsis thaliana) |
eudicotyledons |
TTN51 |
ADP-ribosylation factor-like 2 |
61.96(n) 64.67(a) |
  |
816354 NM_127396.3 NP_179430.1 |
rice (Oryza sativa) |
Liliopsida |
Os.117942 |
Oryza sativa (japonica cultivar-group) cDNA cloneJ more |
69.25(n) |
  |
AK073532.1 |
ENSEMBL Gene Tree for ARL2 (if available) TreeFam Gene Tree for ARL2 (if available)  |
Paralogs for ARL2 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for ARL2 gene
- ARL152 ARL8A2 ARL8B2 ARL32
18/30 SIMAP similar genes for ARL2 using alignment to 2 protein entries: ARL2_HUMAN (see all proteins)
(see all similar genes):ARL17B TRIM23 ARL3 ARF3 ARF5 ARF1 ARF4 ARL9 ARL14 ARL8B ARL4C ARL7 ARL1 ARF6 ARL8A ARL6 SAR1B SARA1
ARL2 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for ARL2 PGOHUM00000257892
|
Genomic Variants for ARL2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 11 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
|---|
HapMap Linkage Disequilibrium report for ARL2 (64781585 - 64789656 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for ARL2: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL2 |
|
Disorders
/ Diseases for ARL2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARL2 for disorders About GeneDecksing
OMIM gene information: 601175
OMIM disorders: --
13 diseases for ARL2: About MalaCardsretinitis pigmentosa-2 spastic paraplegia hereditary spastic paraplegia multiple endocrine neoplasia retinitis pigmentosa paraplegia spasticity retinitis cholera breast cancer immunodeficiency malaria neuronitis Export disorders for ARL2 gene to outside databases
|
Publications for ARL2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARL2 gene, integrated from 9 sources (see all 48): (articles sorted by number of sources associating them with ARL2) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF- like genes. (PubMed id 8415637)1, 2, 3 Clark J....Kahn R.A. (1993)
- ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. (PubMed id 10831612)1, 2, 9 Bhamidipati A....Cowan N.J. (2000)
- ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter. (PubMed id 11809823)1, 2, 9 Sharer J.D.... Kahn R.A. (2002)
- Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity. (PubMed id 20740604)1, 2 Tian G.... Cowan N.J. (2010)
- Crystal structure of the ARL2-GTP-BART complex reveal s a novel recognition and binding mode of small GTPase with effector. (PubMed id 19368893)1, 2 Zhang T....Ding J. (2009)
- Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3- effector-GAP complex. (PubMed id 18588884)1, 2 Veltel S.... Wittinghofer A. (2008)
- Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. (PubMed id 18781797)1, 2 Meierhofer D.... Kaiser P. (2008)
- BART is essential for nuclear retention of STAT3. (PubMed id 18234692)1, 2 Muromoto R....Matsuda T. (2008)
- Arl2 and Arl3 regulate different microtubule-dependent processes. (PubMed id 16525022)1, 2 Zhou C.... Kahn R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
|
External Searches for ARL2 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing ARL2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARL2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARL2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for ARL2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARL2 gene: Search GeneIP for patents involving ARL2
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for ARL2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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