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ARL2 Gene

protein-coding   GIFtS: 56
GCID: GC11P064781

ADP-Ribosylation Factor-Like 2

  See ARL2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 21 2
ARFL22
ADP-Ribosylation Factor-Like Protein 22

External Ids:    HGNC: 6931   Entrez Gene: 4022   Ensembl: ENSG000002134657   OMIM: 6011755   UniProtKB: P364043   

Export aliases for ARL2 gene to outside databases

Previous GC identifers: GC11P067297 GC11U900036 GC11P064558 GC11P064559 GC11P064539 GC11P061108


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARL2 Gene:
This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor
(ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. (provided by RefSeq, Jul
2008)

GeneCards Summary for ARL2 Gene:
ARL2 (ADP-ribosylation factor-like 2) is a protein-coding gene. Diseases associated with ARL2 include retinitis pigmentosa 2. GO annotations related to this gene include GDP binding and GTP binding. An important paralog of this gene is ARL5B.

UniProtKB/Swiss-Prot: ARL2_HUMAN, P36404
Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and
the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins
(GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.
Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule
destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes.
Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly.
Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3.
Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for
normal progress through the cell cycle

Gene Wiki entry for ARL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL2 gene promoter:
         RFX1   Tal-1   p53   MAZR   Brachyury   Egr-1   POU3F2   Egr-4   E47   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL2 promoter sequence
   Search Chromatin IP Primers for ARL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

ARL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL2 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P064781:  view genomic region     (about GC identifiers)

Start:
64,781,585 bp from pter      End:
64,789,657 bp from pter
Size:
8,073 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARL2_HUMAN, P36404 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 2  
Size: 184 amino acids; 20878 Da
Subunit: Found in a complex with ARL2, ARL2BP and SLC25A6. Found in a complex with at least ARL2, PPP2CB, PPP2R1A,
PPP2R2A, PPP2R5E and TBCD. Found in a complex with ARL2, ARL2BP and SLC25A4. The GTP-bound form interacts with
PDE6D. Interacts with ELMOD2. The GTP-bound form interacts with ARL2BP. Interacts, preferentially in its
GDP-bound state, with TBCD. Interacts with UNC119
2 PDB 3D structures from and Proteopedia for ARL2:
3DOE (3D)        3DOF (3D)    
Secondary accessions: G3V184 Q9BUK8
Alternative splicing: 2 isoforms:  P36404-1   P36404-2   

Explore the universe of human proteins at neXtProt for ARL2: NX_P36404

Explore proteomics data for ARL2 at MOPED

Post-translational modifications: 

  • Not N-myristoylated1
  • Ubiquitination2 at Lys53, Lys61, Lys71
  • Modification sites at PhosphoSitePlus

  • See ARL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001186674.1  NP_001658.2  

    ENSEMBL proteins: 
     ENSP00000246747   ENSP00000436021   ENSP00000432971  
    Reactome Protein details: P36404

    ARL2 Human Recombinant Protein Products:

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    antibodies-online proteins for ARL2 (11 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry P36404

    ProtoNet protein and cluster: P36404

    1 Blocks protein domain: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL2_HUMAN, P36404
    Similarity: Belongs to the small GTPase superfamily. Arf family


    Find genes that share domains with ARL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL2_HUMAN, P36404
    Function: Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and
    the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins
    (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit.
    Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule
    destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes.
    Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly.
    Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3.
    Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for
    normal progress through the cell cycle

         Genatlas biochemistry entry for ARL2:
    ADP-ribosylation factor-like 2,low molecular weight GTP binding protein,widely expressed,Ras superfamily member

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IMP10831612
    GO:0004871signal transducer activity ----
    GO:0005095GTPase inhibitor activity TAS10831612
    GO:0005515protein binding IPI10831612
    GO:0005525GTP binding IMP10831612
         
    Find genes that share ontologies with ARL2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARL2:
     Decreased Hepatitis C virus re 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARL2

    miRNA
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    miRTarBase miRNAs that target ARL2:
    hsa-mir-214-3p (MIRT024965), hsa-mir-877-3p (MIRT037049), hsa-mir-92a-3p (MIRT049673), hsa-mir-16-5p (MIRT001478)

    Block miRNA regulation of human, mouse, rat ARL2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL2 (see all 9):
    hsa-miR-3152-3p hsa-miR-15a hsa-miR-497 hsa-miR-214 hsa-miR-424 hsa-miR-195 hsa-miR-16 hsa-miR-761
    SwitchGear 3'UTR luciferase reporter plasmidARL2 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARL2_HUMAN, P36404: Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center,
    centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in
    mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not
    detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not
    detected to interphase microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    mitochondrion5
    nucleus5
    plasma membrane4
    cytosol3
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA18234692
    GO:0005737cytoplasm ----
    GO:0005758mitochondrial intermembrane space IDA11809823
    GO:0005813centrosome IDA16525022

    Find genes that share ontologies with ARL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Find genes that share SuperPaths with ARL2           About GenesLikeMe

    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for ARL2
        Post-chaperonin tubulin folding pathway


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL2
    Interactions:

        GeneGlobe Interaction Network for ARL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARL2 (P364041, 2, 3 ENSP000002467474) via UniProtKB, MINT, STRING, and/or I2D (see all 78)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UNC119Q134321, 2, 3, ENSP000003370404EBI-752365,EBI-711260 MINT-6602303 MINT-6602204 I2D: score=5 STRING: ENSP00000337040
    TBCDQ9BTW92, 3, ENSP000003477194MINT-6602322 I2D: score=4 STRING: ENSP00000347719
    PDE6DO439241, 2, 3, ENSP000002876004EBI-752365,EBI-712685 MINT-6602195 MINT-6602297 I2D: score=8 STRING: ENSP00000287600
    BSNDQ8WZ552, 3, ENSP000003603124MINT-6602213 I2D: score=1 STRING: ENSP00000360312
    ARL2BPQ9Y2Y03, ENSP000002192044I2D: score=3 STRING: ENSP00000219204
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IMP10831612
    GO:0006886intracellular protein transport ----
    GO:0007021tubulin complex assembly TAS10831612
    GO:0007049cell cycle IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----

    Find genes that share ontologies with ARL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL2

    2 Novoseek inferred chemical compound relationships for ARL2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adp 58.7 11 17188265 (2), 19829707 (2), 15372247 (1), 18818514 (1) (see all 6)
    gtp 34.6 2 10488091 (1), 10831612 (1)



    Find genes that share compounds with ARL2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARL2 gene (2 alternative transcripts): 
    NM_001199745.1  NM_001667.3  

    Unigene Cluster for ARL2:

    ADP-ribosylation factor-like 2
    Hs.502836  [show with all ESTs]
    Unigene Representative Sequence: FY212653
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000246747(uc001och.4 uc021qlc.1) ENST00000524585(uc010rnu.2)
    ENST00000529384 ENST00000533729 ENST00000531533 ENST00000529254
    miRNA
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    Additional mRNA sequence: 

    AF493888.1 AK223502.1 AK294580.1 BC002530.2 BT006674.1 L13687.1 

    10 DOTS entries:

    DT.446007  DT.100828285  DT.113150  DT.40189101  DT.92433250  DT.95251277  DT.95070897  DT.95251280 
    DT.75179506  DT.95296513 

    Selected AceView cDNA sequences (see all 324):

    CR619183 CB117465 AA333945 BM853836 CR595019 BQ957603 AW190262 T29292 
    NM_147777 AJ346501 BU730115 AI631767 BM695030 CR614003 CB109435 BQ691172 
    BE279801 CB156380 AW297877 BC014520 BC012767 BC002530 AA325070 BX111746 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGGGAGGGC
    ARL2 Expression
    About this image

    ARL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502836
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARL2 gene from Selected species (see all 25)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl21 , 5 ADP-ribosylation factor-like 21, 5 90.76(n)1
    96.2(a)1
      19 (4.34 cM)5
    563271  NM_019722.31  NP_062696.21 
     61343745 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    89(a)
    1 → many
    GL344077.1(69729-74354)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.115052 Xenopus laevis transcribed sequence with moderate similarity more 77.58(n)    BX853277.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.137682 Transcribed sequence with moderate similarity to protein more 73.69(n)    CK352276.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arf84F1 , 3 protein amino acid ADP-ribosylation GTP
    binding3
    ADP ribosylation factor 84F1
    75(a)3
    67.03(n)1
    75.54(a)1
      84F133
    409931  NM_057538.31  NP_476886.11 
    worm
    (Caenorhabditis elegans)
    Secernentea evl-201 , 3 GTP-binding ADP-ribosylation factor3
    evl-201
    61(a)3
    56.7(n)1
    62.5(a)1
      II(8444128-8445068)3
    1916321  NM_063378.11  NP_495779.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons TTN51 TTN5 61.96(n)
    64.67(a)
      816354  NM_127396.3  NP_179430.1 
    rice
    (Oryza sativa)
    Liliopsida Os.117942 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 69.25(n)    AK073532.1 


    ENSEMBL Gene Tree for ARL2 (if available)
    TreeFam Gene Tree for ARL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL2 gene
    ARL5B2  ENSG000002730032  ARL5C2  ARF42  ENSG000002728222  ARF52  ARF12  ARL32  
    ARL5A2  ARF32  ARF62  TRIM232  
    Selected SIMAP similar genes for ARL2 using alignment to 1 protein entry:     ARL2_HUMAN(see all similar genes):
    ARL3    ARF1    ARL14    ARF5    ARF4    TRIM23
    ARF6    ARF3    ARL1    ARL11    ARL5B    ARL6
    ARL9    ARL5A    ARL8A    SAR1B    ARL8B    SAR1A

    Find genes that share paralogs with ARL2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ARL2
    PGOHUM00000257892


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for ARL2    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs6642261,2,4
    ----see VAR_0280562 mis40--------

    HapMap Linkage Disequilibrium report for ARL2 (64781585 - 64789657 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1174n71CNV Loss21882294
    nsv526181CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL2
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601175    OMIM disorders: --

    1 disease for ARL2:    
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    retinitis pigmentosa 2


    Find genes that share disorders with ARL2           About GenesLikeMe


    Export disorders for ARL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL2 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with ARL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF- like genes. (PubMed id 8415637)1, 2, 3 Clark J....Kahn R.A. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. (PubMed id 10831612)1, 2, 9 Bhamidipati A.... Cowan N.J. (J. Cell Biol. 2000)
    3. ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter. (PubMed id 11809823)1, 2, 9 Sharer J.D.... Kahn R.A. (Mol. Biol. Cell 2002)
    4. Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity. (PubMed id 20740604)1, 2 Tian G.... Cowan N.J. (Cytoskeleton 2010)
    5. Crystal structure of the ARL2-GTP-BART complex reveals a novel recognition and binding mode of small GTPase with effector. (PubMed id 19368893)1, 2 Zhang T.... Ding J. (Structure 2009)
    6. Specificity of Arl2/Arl3 signaling is mediated by a ternary Arl3- effector-GAP complex. (PubMed id 18588884)1, 2 Veltel S.... Wittinghofer A. (FEBS Lett. 2008)
    7. BART is essential for nuclear retention of STAT3. (PubMed id 18234692)1, 2 Muromoto R....Matsuda T. (Int. Immunol. 2008)
    8. Arl2 and Arl3 regulate different microtubule-dependent processes. (PubMed id 16525022)1, 2 Zhou C.... Kahn R.A. (Mol. Biol. Cell 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1, 2 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 402 HGNC: 693 AceView: ARL2andSNX15 Ensembl:ENSG00000213465 euGenes: HUgn402
    ECgene: ARL2 H-InvDB: ARL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARL2 gene:
    Search GeneIP for patents involving ARL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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