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Aliases for ARL2 Gene

Aliases for ARL2 Gene

  • ADP Ribosylation Factor Like GTPase 2 2 3 5
  • ADP-Ribosylation Factor-Like 2 2 3
  • ADP-Ribosylation Factor-Like Protein 2 3
  • ARFL2 3

External Ids for ARL2 Gene

Previous GeneCards Identifiers for ARL2 Gene

  • GC11P067297
  • GC11U900036
  • GC11P064558
  • GC11P064559
  • GC11P064539
  • GC11P064781
  • GC11P061108

Summaries for ARL2 Gene

Entrez Gene Summary for ARL2 Gene

  • This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL2 Gene

ARL2 (ADP Ribosylation Factor Like GTPase 2) is a Protein Coding gene. Diseases associated with ARL2 include Deafness, Autosomal Recessive 88 and Retinitis Pigmentosa 66. Among its related pathways are Metabolism and Chaperonin-mediated protein folding. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL2-SNX15.

UniProtKB/Swiss-Prot for ARL2 Gene

  • Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.

Gene Wiki entry for ARL2 Gene

Additional gene information for ARL2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL2 Gene

Genomics for ARL2 Gene

Regulatory Elements for ARL2 Gene

Enhancers for ARL2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H064970 0.8 ENCODE 20.5 -42.7 -42650 2 RING1 PKNOX1 MAX CCNT2 E2F1 GATA3 POLR2A FOSL2 FOS RFX1 ARL2 GPHA2 SSSCA1-AS1 SNX15 RNASEH2C EHD1 ENSG00000269038 MEN1 TRMT112 EEF1A1P18
GH11H065006 1.1 Ensembl ENCODE 13.7 -6.7 -6656 2 GTF2F1 TBP MXI1 SAP130 JUN MAX SIN3A RAD21 RFX5 ZKSCAN1 ARL2 EEF1A1P18 EHBP1L1 BATF2 ARL2-SNX15
GH11H064846 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5.3 -157.1 -157060 20 HDGF PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZNF207 EHD1 EHBP1L1 MAP4K2 MIR192 MEN1 MAJIN GPHA2 MAP3K11 CDC42EP2 CDC42BPG
GH11H065065 0.9 Ensembl ENCODE 11.8 +53.0 53012 2 ZNF687 SAP130 NR2F1 HLF JUNB BATF POLR2A EED IKZF1 NR2F6 SNX15 ARL2 VPS51 ENSG00000254501 TM7SF2 CDC42BPG MAJIN EHD1 MEN1 LOC728975
GH11H065414 2.2 FANTOM5 Ensembl ENCODE dbSUPER 4.6 +410.1 410069 18 MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 MEF2D SF1 LOC105369352 ZFPL1 KAT5 SART1 MUS81 EIF1AD PCNX3 POLA2 SF3B2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL2 on UCSC Golden Path with GeneCards custom track

Promoters for ARL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040764 187 1401 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ZNF766 ZNF207

Genomic Location for ARL2 Gene

Chromosome:
11
Start:
65,014,113 bp from pter
End:
65,022,185 bp from pter
Size:
8,073 bases
Orientation:
Plus strand

Genomic View for ARL2 Gene

Genes around ARL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL2 Gene

Proteins for ARL2 Gene

  • Protein details for ARL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36404-ARL2_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 2
    Protein Accession:
    P36404
    Secondary Accessions:
    • G3V184
    • Q9BUK8

    Protein attributes for ARL2 Gene

    Size:
    184 amino acids
    Molecular mass:
    20878 Da
    Quaternary structure:
    • Found in a complex with ARL2, ARL2BP and SLC25A6. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Found in a complex with ARL2, ARL2BP and SLC25A4. The GTP-bound form interacts with PDE6D. Interacts with ELMOD2. The GTP-bound form interacts with ARL2BP. Interacts, preferentially in its GDP-bound state, with TBCD. Interacts with UNC119.

    Three dimensional structures from OCA and Proteopedia for ARL2 Gene

    Alternative splice isoforms for ARL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL2 Gene

Post-translational modifications for ARL2 Gene

Other Protein References for ARL2 Gene

No data available for DME Specific Peptides for ARL2 Gene

Domains & Families for ARL2 Gene

Gene Families for ARL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ARL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36404

UniProtKB/Swiss-Prot:

ARL2_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL2: view

Function for ARL2 Gene

Molecular function for ARL2 Gene

GENATLAS Biochemistry:
ADP-ribosylation factor-like 2,low molecular weight GTP binding protein,widely expressed,Ras superfamily member
UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.

Phenotypes From GWAS Catalog for ARL2 Gene

Gene Ontology (GO) - Molecular Function for ARL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IMP 10831612
GO:0005095 GTPase inhibitor activity TAS 10831612
GO:0005515 protein binding IPI 10831612
GO:0005525 GTP binding IMP 10831612
genes like me logo Genes that share ontologies with ARL2: view
genes like me logo Genes that share phenotypes with ARL2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL2
  • Applied Biological Materials Clones for ARL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL2 Gene

Localization for ARL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL2 Gene

Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL2 gene
Compartment Confidence
extracellular 5
cytoskeleton 5
mitochondrion 5
nucleus 5
cytosol 5
golgi apparatus 5
plasma membrane 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Focal adhesion sites (2)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA,IEA 18234692
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with ARL2: view

Pathways & Interactions for ARL2 Gene

genes like me logo Genes that share pathways with ARL2: view

Gene Ontology (GO) - Biological Process for ARL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007021 tubulin complex assembly TAS 10831612
GO:0007049 cell cycle IEA --
GO:0007098 centrosome cycle IMP 16525022
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0010811 positive regulation of cell-substrate adhesion ISS --
genes like me logo Genes that share ontologies with ARL2: view

No data available for SIGNOR curated interactions for ARL2 Gene

Drugs & Compounds for ARL2 Gene

(2) Additional Compounds for ARL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARL2: view

Transcripts for ARL2 Gene

Unigene Clusters for ARL2 Gene

ADP-ribosylation factor-like 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL2
  • Applied Biological Materials Clones for ARL2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ARL2 Gene

No ASD Table

Relevant External Links for ARL2 Gene

GeneLoc Exon Structure for
ARL2
ECgene alternative splicing isoforms for
ARL2

Expression for ARL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL2 Gene

Protein differential expression in normal tissues from HIPED for ARL2 Gene

This gene is overexpressed in Bone (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARL2 Gene



Protein tissue co-expression partners for ARL2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL2 Gene:

ARL2

SOURCE GeneReport for Unigene cluster for ARL2 Gene:

Hs.502836

Evidence on tissue expression from TISSUES for ARL2 Gene

  • Nervous system(4.7)
  • Intestine(2.2)
  • Kidney(2.1)
genes like me logo Genes that share expression patterns with ARL2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL2 Gene

Orthologs for ARL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL2 33
  • 95.65 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 95 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ARL2 33 34
  • 93.84 (n)
dog
(Canis familiaris)
Mammalia ARL2 33
  • 92.75 (n)
mouse
(Mus musculus)
Mammalia Arl2 33 16 34
  • 90.76 (n)
rat
(Rattus norvegicus)
Mammalia Arl2 33
  • 90.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 57 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 89 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arl2 33
  • 75.91 (n)
MGC75676 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.11505 33
zebrafish
(Danio rerio)
Actinopterygii arl2 33 34
  • 71.38 (n)
Dr.13768 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1138 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005267 33
  • 70.65 (n)
fruit fly
(Drosophila melanogaster)
Insecta Arf84F 35 33 34
  • 67.03 (n)
worm
(Caenorhabditis elegans)
Secernentea evl-20 35 33 34
  • 56.7 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CIN4 36
thale cress
(Arabidopsis thaliana)
eudicotyledons TTN5 33
  • 61.96 (n)
rice
(Oryza sativa)
Liliopsida Os02g0327100 33
  • 65.02 (n)
Os.11794 33
barley
(Hordeum vulgare)
Liliopsida Hv.4477 33
corn
(Zea mays)
Liliopsida Zm.12954 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2707 34
  • 80 (a)
OneToMany
bread mold
(Neurospora crassa)
Ascomycetes NCU00218 33
  • 62.57 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alp41 33
  • 49.05 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1357 33
Species where no ortholog for ARL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL2 Gene

ENSEMBL:
Gene Tree for ARL2 (if available)
TreeFam:
Gene Tree for ARL2 (if available)

Paralogs for ARL2 Gene

Paralogs for ARL2 Gene

(29) SIMAP similar genes for ARL2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ARL2 Gene

genes like me logo Genes that share paralogs with ARL2: view

Variants for ARL2 Gene

Sequence variations from dbSNP and Humsavar for ARL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000042185 -- 65,014,790(+) GTGTG(G/T)GTGTG intron-variant
rs1000117241 -- 65,016,642(+) AGAAC(-/CCTGTGTGTG)CCTGT intron-variant, upstream-variant-2KB
rs1000221831 -- 65,017,768(+) GAAGA(C/T)AGAGG intron-variant, upstream-variant-2KB
rs1000278734 -- 65,022,366(+) GCTTC(C/T)TAAAG intron-variant
rs1000366738 -- 65,020,891(+) AGAAA(A/G)AAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL2 Gene

Variant ID Type Subtype PubMed ID
esv3626667 CNV loss 21293372
esv3626668 CNV gain 21293372
nsv526181 CNV gain 19592680

Variation tolerance for ARL2 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.29; 94.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL2 Gene

Disorders for ARL2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ARL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
deafness, autosomal recessive 88
  • autosomal recessive nonsyndromic deafness 88
retinitis pigmentosa 66
  • rp66
hypoparathyroidism-retardation-dysmorphism syndrome
  • hrd syndrome
retinitis pigmentosa
  • retinitis pigmentosa 1
joubert syndrome 1
  • joubert syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ARL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL2
genes like me logo Genes that share disorders with ARL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL2 Gene

Publications for ARL2 Gene

  1. ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter. (PMID: 11809823) Sharer JD … Kahn RA (Molecular biology of the cell 2002) 3 4 22 60
  2. ADP ribosylation factor-like protein 2 (Arl2) regulates the interaction of tubulin-folding cofactor D with native tubulin. (PMID: 10831612) Bhamidipati A … Cowan NJ (The Journal of cell biology 2000) 3 4 22 60
  3. The ARF-like 2 (ARL2)-binding protein, BART. Purification, cloning, and initial characterization. (PMID: 10488091) Sharer JD … Kahn RA (The Journal of biological chemistry 1999) 3 4 22 60
  4. Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF-like genes. (PMID: 8415637) Clark J … Kahn RA (Proceedings of the National Academy of Sciences of the United States of America 1993) 2 3 4 60
  5. Effect of TBCD and its regulatory interactor Arl2 on tubulin and microtubule integrity. (PMID: 20740604) Tian G … Cowan NJ (Cytoskeleton (Hoboken, N.J.) 2010) 3 4 60

Products for ARL2 Gene

  • Addgene plasmids for ARL2

Sources for ARL2 Gene

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