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Aliases for ARL2 Gene

Aliases for ARL2 Gene

  • ADP Ribosylation Factor Like GTPase 2 2 3 5
  • ADP-Ribosylation Factor-Like 2 2 3
  • ADP-Ribosylation Factor Like GTPase 2 3
  • ARFL2 3

External Ids for ARL2 Gene

Previous GeneCards Identifiers for ARL2 Gene

  • GC11P067297
  • GC11U900036
  • GC11P064558
  • GC11P064559
  • GC11P064539
  • GC11P064781
  • GC11P061108

Summaries for ARL2 Gene

Entrez Gene Summary for ARL2 Gene

  • This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARL2 Gene

ARL2 (ADP Ribosylation Factor Like GTPase 2) is a Protein Coding gene. Diseases associated with ARL2 include retinitis pigmentosa 2 and hypoparathyroidism-retardation-dysmorphism syndrome. Among its related pathways are Metabolism and Transport to the Golgi and subsequent modification. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ENSG00000272822.

UniProtKB/Swiss-Prot for ARL2 Gene

  • Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.

Gene Wiki entry for ARL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL2 Gene

Genomics for ARL2 Gene

Regulatory Elements for ARL2 Gene

Promoters for ARL2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARL2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL2 Gene

Chromosome:
11
Start:
65,014,113 bp from pter
End:
65,022,185 bp from pter
Size:
8,073 bases
Orientation:
Plus strand

Genomic View for ARL2 Gene

Genes around ARL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL2 Gene

Proteins for ARL2 Gene

  • Protein details for ARL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36404-ARL2_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 2
    Protein Accession:
    P36404
    Secondary Accessions:
    • G3V184
    • Q9BUK8

    Protein attributes for ARL2 Gene

    Size:
    184 amino acids
    Molecular mass:
    20878 Da
    Quaternary structure:
    • Found in a complex with ARL2, ARL2BP and SLC25A6. Found in a complex with at least ARL2, PPP2CB, PPP2R1A, PPP2R2A, PPP2R5E and TBCD. Found in a complex with ARL2, ARL2BP and SLC25A4. The GTP-bound form interacts with PDE6D. Interacts with ELMOD2. The GTP-bound form interacts with ARL2BP. Interacts, preferentially in its GDP-bound state, with TBCD. Interacts with UNC119.

    Three dimensional structures from OCA and Proteopedia for ARL2 Gene

    Alternative splice isoforms for ARL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL2 Gene

Proteomics data for ARL2 Gene at MOPED

Post-translational modifications for ARL2 Gene

Other Protein References for ARL2 Gene

Antibody Products

No data available for DME Specific Peptides for ARL2 Gene

Domains & Families for ARL2 Gene

Gene Families for ARL2 Gene

Protein Domains for ARL2 Gene

Suggested Antigen Peptide Sequences for ARL2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36404

UniProtKB/Swiss-Prot:

ARL2_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL2: view

Function for ARL2 Gene

Molecular function for ARL2 Gene

GENATLAS Biochemistry:
ADP-ribosylation factor-like 2,low molecular weight GTP binding protein,widely expressed,Ras superfamily member
UniProtKB/Swiss-Prot Function:
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.
genes like me logo Genes that share phenotypes with ARL2: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL2 Gene

Localization for ARL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL2 Gene

Mitochondrion intermembrane space. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus. Cytoplasm. Note=The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL2 Gene COMPARTMENTS Subcellular localization image for ARL2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
mitochondrion 5
nucleus 5
plasma membrane 4
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ARL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18234692
GO:0005813 centrosome IDA 16525022
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with ARL2: view

Pathways & Interactions for ARL2 Gene

genes like me logo Genes that share pathways with ARL2: view

Gene Ontology (GO) - Biological Process for ARL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007021 tubulin complex assembly TAS 10831612
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0031116 positive regulation of microtubule polymerization IDA 10831612
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with ARL2: view

No data available for SIGNOR curated interactions for ARL2 Gene

Drugs & Compounds for ARL2 Gene

(2) Additional Compounds for ARL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARL2: view

Transcripts for ARL2 Gene

Unigene Clusters for ARL2 Gene

ADP-ribosylation factor-like 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL2 Gene

No ASD Table

Relevant External Links for ARL2 Gene

GeneLoc Exon Structure for
ARL2
ECgene alternative splicing isoforms for
ARL2

Expression for ARL2 Gene

mRNA expression in normal human tissues for ARL2 Gene

Protein differential expression in normal tissues from HIPED for ARL2 Gene

This gene is overexpressed in Bone (24.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL2 Gene



SOURCE GeneReport for Unigene cluster for ARL2 Gene Hs.502836

genes like me logo Genes that share expression patterns with ARL2: view

Protein tissue co-expression partners for ARL2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARL2 Gene

Orthologs for ARL2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL2 35
  • 95.65 (n)
  • 94.57 (a)
cow
(Bos Taurus)
Mammalia ARL2 36
  • 98 (a)
OneToMany
ARL2 35
  • 93.84 (n)
  • 98.37 (a)
dog
(Canis familiaris)
Mammalia ARL2 35
  • 92.75 (n)
  • 98.91 (a)
mouse
(Mus musculus)
Mammalia Arl2 36
  • 96 (a)
OneToMany
Arl2 35
  • 90.76 (n)
  • 96.2 (a)
Arl2 16
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 95 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 57 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arl2 35
  • 90.04 (n)
  • 95.11 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 89 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.11505 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arl2 35
  • 75.91 (n)
  • 89.67 (a)
MGC75676 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1138 35
zebrafish
(Danio rerio)
Actinopterygii arl2 35
  • 71.38 (n)
  • 84.78 (a)
Dr.13768 35
arl2 36
  • 85 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005267 35
  • 70.65 (n)
  • 72.83 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arf84F 37
  • 75 (a)
Arf84F 35
  • 67.03 (n)
  • 75.54 (a)
Arf84F 36
  • 76 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea evl-20 36
  • 63 (a)
OneToMany
evl-20 37
  • 61 (a)
evl-20 35
  • 56.7 (n)
  • 62.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CIN4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons TTN5 35
  • 61.96 (n)
  • 64.67 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.4477 35
corn
(Zea mays)
Liliopsida Zm.12954 35
rice
(Oryza sativa)
Liliopsida Os.11794 35
Os02g0327100 35
  • 65.02 (n)
  • 64.29 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00218 35
  • 62.57 (n)
  • 63.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes alp41 35
  • 49.05 (n)
  • 55.11 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1357 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2707 36
  • 80 (a)
OneToMany
Species with no ortholog for ARL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL2 Gene

ENSEMBL:
Gene Tree for ARL2 (if available)
TreeFam:
Gene Tree for ARL2 (if available)

Paralogs for ARL2 Gene

(29) SIMAP similar genes for ARL2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for ARL2 Gene

genes like me logo Genes that share paralogs with ARL2: view

Variants for ARL2 Gene

Sequence variations from dbSNP and Humsavar for ARL2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_028056 -

Structural Variations from Database of Genomic Variants (DGV) for ARL2 Gene

Variant ID Type Subtype PubMed ID
nsv526181 CNV Gain 19592680
dgv1174n71 CNV Loss 21882294

Variation tolerance for ARL2 Gene

Residual Variation Intolerance Score: 56.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.29; 94.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL2 Gene

HapMap Linkage Disequilibrium report
ARL2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL2 Gene

Disorders for ARL2 Gene

MalaCards: The human disease database

(4) MalaCards diseases for ARL2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
retinitis pigmentosa 2
  • x-linked retinitis pigmentosa 2
hypoparathyroidism-retardation-dysmorphism syndrome
  • hrd syndrome
retinitis pigmentosa
  • retinitis pigmentosa 1
joubert syndrome 1
  • joubert syndrome
- elite association - COSMIC cancer census association via MalaCards
Search ARL2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARL2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL2
genes like me logo Genes that share disorders with ARL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL2 Gene

Publications for ARL2 Gene

  1. Selective amplification of additional members of the ADP-ribosylation factor (ARF) family: cloning of additional human and Drosophila ARF- like genes. (PMID: 8415637) Clark J. … Kahn R.A. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 67
  2. Beta-tubulin cofactor D and ARL2 take part in apical junctional complex disassembly and abrogate epithelial structure. (PMID: 17704193) Shultz T. … Altschuler Y. (FASEB J. 2008) 3 23
  3. Expression of Arl2 is associated with p53 localization and chemosensitivity in a breast cancer cell line. (PMID: 18818514) BAcghin A. … Dumontet C. (Cell Cycle 2008) 3 23
  4. ADP ribosylation factor like 2 (Arl2) protein influences microtubule dynamics in breast cancer cells. (PMID: 17188265) Beghin A. … Dumontet C. (Exp. Cell Res. 2007) 3 23
  5. Photoreceptor synaptic protein HRG4 (UNC119) interacts with ARL2 via a putative conserved domain. (PMID: 12527357) Kobayashi A. … Inana G. (FEBS Lett. 2003) 3 23

Products for ARL2 Gene

Sources for ARL2 Gene

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