External Ids for ARL2 Gene
Previous GeneCards Identifiers for ARL2 Gene
This gene encodes a small GTP-binding protein of the RAS superfamily which functions as an ADP-ribosylation factor (ARF). The encoded protein is one of a functionally distinct group of ARF-like genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARL2 Gene
ARL2 (ADP-Ribosylation Factor-Like 2) is a Protein Coding gene. Diseases associated with ARL2 include retinitis pigmentosa 2 and joubert syndrome 1. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ENSG00000272822.
UniProtKB/Swiss-Prot for ARL2 Gene
Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.