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Aliases for ARL17B Gene

Aliases for ARL17B Gene

  • ADP Ribosylation Factor Like GTPase 17B 2 3 5
  • ADP-Ribosylation Factor-Like 17B 2 3
  • ARL17A 3 4
  • ADP-Ribosylation Factor-Like Protein 17 3
  • ADP-Ribosylation Factor 7 Variant 4
  • ADP-Ribosylation Factor-Like 17 2
  • ADP-Ribosylation Factor 7 3
  • ARL17A ARL17B 4
  • ARL17P1 4
  • ARF1P2 4
  • ARL17 3

External Ids for ARL17B Gene

Previous HGNC Symbols for ARL17B Gene

  • ARL17

Previous GeneCards Identifiers for ARL17B Gene

  • GC17M041732
  • GC17M044596
  • GC17Pp43777
  • GC17M044377
  • GC17M044352

Summaries for ARL17B Gene

GeneCards Summary for ARL17B Gene

ARL17B (ADP Ribosylation Factor Like GTPase 17B) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL17A.

UniProtKB/Swiss-Prot for ARL17B Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL17B Gene

Genomics for ARL17B Gene

Regulatory Elements for ARL17B Gene

Enhancers for ARL17B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G046741 1.3 Ensembl ENCODE 118.3 -380.7 -380655 2.6 ARNT ZFP64 SIN3A FEZF1 ZNF2 FOS SP3 JUNB REST ZNF592 ARL17B MRPL45P2 KANSL1-AS1 ENSG00000253347 ENSG00000262372 RPS7P11 LRRC37A17P KANSL1 NSFP1 RPS2P47
GH17G047069 1.5 Ensembl ENCODE 63.3 -709.1 -709140 4.4 CREB3L1 MLX AGO1 ZFP64 DMAP1 YBX1 FEZF1 YY1 SLC30A9 ZNF143 ARL17B MRPL45P2 KANSL1 LOC101927060 CDC27 ENSG00000266601 LRRC37A17P ENSG00000264701 RPS2P47 ENSG00000253347
GH17G046263 1.8 FANTOM5 Ensembl ENCODE 43 +96.1 96140 4.5 CREB3L1 ZFP64 YBX1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D LRRC37A4P LINC02210 ARL17B KANSL1 ENSG00000262372 RPS7P11 KANSL1-AS1 NSFP1 MAPK8IP1P1 RPS2P47
GH17G046286 1.3 Ensembl ENCODE 37.5 +75.2 75227 1.1 HDGF ARID4B SIN3A YBX1 ZNF2 ZNF121 GLIS2 ZNF143 FOS REST LRRC37A4P ARL17B KANSL1 ENSG00000262372 RPS2P47 RPS7P11 PIR51250 GC17P046306 GC17P046302 GC17P046299
GH17G046189 1.8 FANTOM5 ENCODE dbSUPER 21.9 +168.5 168492 7.6 CREB3L1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 LINC02210 LRRC37A4P KANSL1 ARL17B ENSG00000262372 LRRC37A2 KANSL1-AS1 NSFP1 RPS7P11 LRRC37A17P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL17B on UCSC Golden Path with GeneCards custom track

Promoters for ARL17B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000095060 464 2001 PKNOX1 DDX20 SP2 NR3C1 TBX21 ATF2 SP1 ZNF316 PRDM10 PRDM1

Genomic Location for ARL17B Gene

Chromosome:
17
Start:
46,274,184 bp from pter
End:
46,362,064 bp from pter
Size:
87,881 bases
Orientation:
Minus strand

Genomic View for ARL17B Gene

Genes around ARL17B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL17B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL17B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL17B Gene

Proteins for ARL17B Gene

  • Protein details for ARL17B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVW1-ARL17_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 17
    Protein Accession:
    Q8IVW1
    Secondary Accessions:
    • B0AZR6
    • Q59FW5
    • Q8N6E2
    • Q8TD73
    • Q8WW54
    • Q9NZD5
    • Q9P158

    Protein attributes for ARL17B Gene

    Size:
    177 amino acids
    Molecular mass:
    19388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF64278.1; Type=Frameshift; Positions=114; Evidence={ECO:0000305}; Sequence=AAF69643.1; Type=Frameshift; Positions=17; Evidence={ECO:0000305}; Sequence=AAH30570.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92581.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARL17B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL17B Gene

Post-translational modifications for ARL17B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARL17B Gene

Domains & Families for ARL17B Gene

Gene Families for ARL17B Gene

Protein Domains for ARL17B Gene

Suggested Antigen Peptide Sequences for ARL17B Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVW1

UniProtKB/Swiss-Prot:

ARL17_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL17B: view

Function for ARL17B Gene

Molecular function for ARL17B Gene

UniProtKB/Swiss-Prot Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

Gene Ontology (GO) - Molecular Function for ARL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL17B: view

Phenotypes for ARL17B Gene

GenomeRNAi human phenotypes for ARL17B:
genes like me logo Genes that share phenotypes with ARL17B: view

Animal Model Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL17B Gene

Localization for ARL17B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL17B Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL17B gene
Compartment Confidence
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for ARL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with ARL17B: view

Pathways & Interactions for ARL17B Gene

SuperPathways for ARL17B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL17B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ARL17B: view

No data available for Pathways by source and SIGNOR curated interactions for ARL17B Gene

Drugs & Compounds for ARL17B Gene

No Compound Related Data Available

Transcripts for ARL17B Gene

mRNA/cDNA for ARL17B Gene

(12) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL17B Gene

ADP-ribosylation factor-like 17B:
Representative Sequences:

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL17B Gene

No ASD Table

Relevant External Links for ARL17B Gene

GeneLoc Exon Structure for
ARL17B
ECgene alternative splicing isoforms for
ARL17B

Expression for ARL17B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL17B Gene

Protein differential expression in normal tissues from HIPED for ARL17B Gene

This gene is overexpressed in Cerebrospinal fluid (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL17B Gene



Protein tissue co-expression partners for ARL17B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL17B Gene:

ARL17B

SOURCE GeneReport for Unigene cluster for ARL17B Gene:

Hs.720602

Evidence on tissue expression from TISSUES for ARL17B Gene

  • Nervous system(4.5)
  • Kidney(4.3)
  • Bone marrow(4)
genes like me logo Genes that share expression patterns with ARL17B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL17B Gene

Orthologs for ARL17B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ARL17B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
Species where no ortholog for ARL17B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARL17B Gene

ENSEMBL:
Gene Tree for ARL17B (if available)
TreeFam:
Gene Tree for ARL17B (if available)

Paralogs for ARL17B Gene

Variants for ARL17B Gene

Sequence variations from dbSNP and Humsavar for ARL17B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000034851 -- 46,351,677(+) TGCCA(A/C)AGGTA intron-variant
rs1000194431 -- 46,279,679(+) TTTGT(A/T)AAGAT intron-variant
rs1000424148 -- 46,286,396(+) ACCAT(G/T)TGGGA intron-variant, downstream-variant-500B
rs1000464573 -- 46,313,251(+) ATCTA(C/T)TTTGA intron-variant
rs1000760940 -- 46,289,816(+) TTTTA(-/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL17B Gene

Variant ID Type Subtype PubMed ID
dgv127e55 CNV gain 17911159
dgv13n31 CNV gain 19718026
dgv14n31 CNV gain 19718026
dgv15n14 CNV loss 18776910
dgv16n14 CNV loss 18776910
dgv29e213 CNV loss 24956385
dgv30e213 CNV gain 24956385
dgv3184n100 CNV gain 25217958
dgv3185n100 CNV gain 25217958
dgv3188n100 CNV gain 25217958
dgv3189n100 CNV gain 25217958
dgv3190n100 CNV gain 25217958
dgv3196n100 CNV gain+loss 25217958
dgv3198n100 CNV loss 25217958
dgv3206n100 CNV loss 25217958
dgv3209n100 CNV gain 25217958
dgv3214n100 CNV gain+loss 25217958
dgv3232n100 CNV loss 25217958
dgv3233n100 CNV gain 25217958
dgv3238n100 CNV gain 25217958
dgv3239n100 CNV gain 25217958
dgv3240n100 CNV gain 25217958
dgv3241n100 CNV loss 25217958
dgv3242n100 CNV gain+loss 25217958
dgv3244n100 CNV loss 25217958
dgv3245n100 CNV gain+loss 25217958
dgv3246n100 CNV gain+loss 25217958
dgv3247n100 CNV gain 25217958
dgv3248n100 CNV loss 25217958
dgv3249n100 CNV gain 25217958
dgv3250n100 CNV gain+loss 25217958
dgv3251n100 CNV loss 25217958
dgv3252n100 CNV loss 25217958
dgv3253n100 CNV loss 25217958
dgv3254n100 CNV gain+loss 25217958
dgv3255n100 CNV gain 25217958
dgv3256n100 CNV loss 25217958
dgv3257n100 CNV loss 25217958
dgv3258n100 CNV gain+loss 25217958
dgv3259n100 CNV loss 25217958
dgv3260n100 CNV loss 25217958
dgv5618n54 CNV gain 21841781
dgv5623n54 CNV loss 21841781
dgv5628n54 CNV loss 21841781
dgv5638n54 CNV gain 21841781
dgv5641n54 CNV loss 21841781
dgv5642n54 CNV loss 21841781
dgv5643n54 CNV gain 21841781
dgv5644n54 CNV gain 21841781
dgv5645n54 CNV loss 21841781
dgv5646n54 CNV gain+loss 21841781
dgv5647n54 CNV loss 21841781
dgv5648n54 CNV gain+loss 21841781
dgv5649n54 CNV loss 21841781
dgv5650n54 CNV gain 21841781
dgv5651n54 CNV loss 21841781
dgv5657n54 CNV loss 21841781
dgv5658n54 CNV loss 21841781
dgv5659n54 CNV loss 21841781
dgv5660n54 CNV gain+loss 21841781
dgv939e212 CNV gain 25503493
dgv940e212 CNV loss 25503493
esv1003686 CNV gain 20482838
esv21783 CNV gain+loss 19812545
esv2421412 OTHER complex 20811451
esv2656635 CNV deletion 23128226
esv2758692 CNV gain+loss 17122850
esv2760451 CNV gain+loss 21179565
esv2762433 CNV gain+loss 21179565
esv33048 CNV gain+loss 17666407
esv3395024 CNV duplication 20981092
esv3430044 CNV duplication 20981092
esv3444693 CNV duplication 20981092
esv3584722 CNV loss 24956385
esv3893017 CNV gain+loss 25118596
esv3893019 CNV gain+loss 25118596
esv3893020 CNV gain 25118596
esv3893021 CNV gain 25118596
esv3893023 CNV gain+loss 25118596
esv3893024 CNV gain 25118596
nsv1061687 CNV loss 25217958
nsv1063349 CNV gain 25217958
nsv1063380 CNV gain 25217958
nsv1070410 CNV deletion 25765185
nsv1072741 CNV deletion 25765185
nsv1118761 CNV deletion 24896259
nsv1126463 CNV deletion 24896259
nsv1133408 CNV deletion 24896259
nsv1136238 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv1160492 CNV duplication 26073780
nsv1160494 CNV deletion 26073780
nsv163 CNV deletion 15895083
nsv2070 CNV deletion 18451855
nsv428343 CNV gain+loss 18775914
nsv433450 CNV gain 18776910
nsv433451 CNV gain 18776910
nsv442749 CNV gain+loss 18776908
nsv469644 CNV gain+loss 16826518
nsv469697 CNV gain+loss 16826518
nsv471401 CNV gain+loss 19718026
nsv471514 CNV gain 19718026
nsv471698 CNV gain+loss 15918152
nsv471700 CNV gain+loss 15918152
nsv482202 CNV gain 20164927
nsv510715 CNV deletion 20534489
nsv511057 OTHER complex 20534489
nsv516807 CNV gain+loss 19592680
nsv575266 CNV gain 21841781
nsv575272 CNV loss 21841781
nsv575314 CNV gain+loss 21841781
nsv575387 CNV gain+loss 21841781
nsv575388 CNV gain 21841781
nsv575389 CNV loss 21841781
nsv819319 CNV loss 19587683
nsv820933 CNV deletion 20802225
nsv821581 CNV deletion 20802225
nsv821687 CNV gain 15273396
nsv833463 CNV loss 17160897
nsv833464 CNV gain 17160897
nsv953912 CNV deletion 24416366
nsv953916 CNV duplication 24416366
nsv9564 CNV gain+loss 18304495
nsv960494 CNV duplication 23825009
nsv960495 CNV duplication 23825009
nsv960604 CNV duplication 23825009
nsv978553 CNV duplication 23825009

Relevant External Links for ARL17B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL17B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ARL17B Gene

Disorders for ARL17B Gene

Relevant External Links for ARL17B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL17B

No disorders were found for ARL17B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL17B Gene

Publications for ARL17B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PMID: 19608861) Choudhary C. … Mann M. (Science 2009) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
  5. The sequence of the human genome. (PMID: 11181995) Venter J.C. … Zhu X. (Science 2001) 3 64

Products for ARL17B Gene

Sources for ARL17B Gene

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