ARL17B Gene
protein-coding GIFtS: 35
GCID: GC17M044352
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ADP-ribosylation factor-like 17B(Previous name: ADP-ribosylation factor-like 17 )
(Previous symbol: ARL17)
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Aliases
for ARL17B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADP-Ribosylation Factor-Like 17B1 2 | | ADP-Ribosylation Factor-Like Protein 172 | | ARL171 2 | | ARF1P23 | | ARL17A2 3 | | ARL17P13 | | ADP-Ribosylation Factor-Like 171 | | ADP-Ribosylation Factor 7 Variant3 | | ADP-Ribosylation Factor 72 | | |
Export aliases for ARL17B gene to outside databasesPrevious GC identifers: GC17M041732 GC17M044596 GC17Pp43777 GC17M044377 |
Summaries
for ARL17B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ARL17_HUMAN, Q8IVW1Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, anADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgiapparatus (By similarity)
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Genomic Views
for ARL17B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NT_010783.15 NC_018928.1
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ARL17B
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARL17B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL17B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31ARL17B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M044352: view genomic region
(about GC identifiers)
Start:
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44,352,150 bp from pter |
End:
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44,439,163 bp from pter |
Size:
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87,014 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr17+,ALT_REF_LOCI_9 43,776,446-43,839,462 |
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Proteins
for ARL17B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARL17_HUMAN, Q8IVW1 (See
protein sequence)Recommended Name: ADP-ribosylation factor-like protein 17 Size: 177 amino acids; 19388 Da
Subcellular location: Golgi apparatus (By similarity)
Sequence caution: Sequence=AAF64278.1; Type=Frameshift; Positions=114; Sequence=AAF69643.1; Type=Frameshift;Positions=17; Sequence=AAH30570.1; Type=Erroneous initiation; Sequence=BAD92581.1; Type=Erroneous initiation;
Secondary accessions: B0AZR6 Q59FW5 Q8N6E2 Q8TD73 Q8WW54 Q9NZD5 Q9P158Alternative splicing: 3 isoforms: Q8IVW1-1 Q8IVW1-2 Q8IVW1-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARL17B: NX_Q8IVW1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IVW1
ARL17B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001034172.3 NP_001096624.1
ENSEMBL proteins: ENSP00000459151 ENSP00000391751 ENSP00000458681 ENSP00000459131 ENSP00000460539 ENSP00000459773 ENSP00000404247
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ARL17B for ontologies About GeneDecksing
ARL17B Antibody Products:
Assay Products for ARL17B: |
Protein
Domains /
Families
for ARL17B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARL17B for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IVW1ProtoNet protein and cluster: Q8IVW1 1 Blocks protein family: IPB006688 ADP-ribosylation factor
UniProtKB/Swiss-Prot: ARL17_HUMAN, Q8IVW1Similarity: Belongs to the small GTPase superfamily. Arf family |
Function
for ARL17B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARL17_HUMAN, Q8IVW1Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, anADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgiapparatus (By similarity)
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL17B |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005525 | GTP binding |
IEA | -- |
ARL17B for ontologies About GeneDecksing
|
Pathways & Interactions
for ARL17B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL17B
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- | | GO:0015031 | protein transport |
IEA | -- | | GO:0016192 | vesicle-mediated transport |
IEA | -- |
ARL17B for ontologies About GeneDecksing
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Drugs & Compounds
for ARL17B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARL17B
Search CenterWatch for drugs/clinical trials and news about ARL17B / ARL17 
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Transcripts
for ARL17B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARL17B gene (2 alternative transcripts): NM_001039083.3 NM_001103154.1 Unigene Clusters for ARL17B: ADP-ribosylation factor-like 17B Hs.720602 [show with all ESTs], Hs.733127 [show with all ESTs]Unigene Representative Sequences: BC071681, NM_0011137387 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000570618 ENST00000434041(uc002iki.4) ENST00000572991(uc002ikf.3)
ENST00000575698 ENST00000575960 ENST00000571246 ENST00000450673(uc002ikk.3 uc021tyy.1)
Additional cDNA sequence: AB209344.1 AF208864.1 AF493886.1 AK289590.1 AK315857.1 BC030570.1 BC041803.1 BX537922.1 BX647266.1 19 DOTS entries: DT.92417048 DT.97838754 DT.311290 DT.100832873 DT.120973333 DT.40238154 DT.95298833 DT.120946209 DT.92464060 DT.99928669 DT.75101825 DT.92052087 DT.95084918 DT.102839958 DT.120973264 DT.120982799 DT.120983076 DT.120983138 DT.95340910
GeneLoc Exon Structure
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Expression
for ARL17B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARL17B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ARL17B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARL17B
SOURCE GeneReport for Unigene clusters: Hs.720602 Hs.733127
SABiosciences Custom PCR Arrays for ARL17B
Primer
Products: |  | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ARL17B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL17B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL17B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL17B |
Orthologs
for ARL17B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ARL17B gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for ARL17B (if available)
TreeFam Gene Tree for ARL17B (if available) |
Paralogs
for ARL17B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARL17B gene
- ARL4A2 ARL112 ARF42 ARF52 ARF12 ARL4D2 ARF32 ARL142
- ARF62 ARL92 ARL4C2 TRIM232 ARL102
14 SIMAP similar genes for ARL17B using alignment to 4 protein entries: ARL17_HUMAN (see all proteins):ARL17A ARL17 NBR2 ARF1 ARF3 ARL1
ARF5 ARF6 ARL2 ARF4 ARL5B ARL6
ARL5A SAR1B
ARL17B for paralogs About GeneDecksing
|
Genomic Variants
for ARL17B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARL17B (44352150 - 44439163 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 29 variations for ARL17B
15/28 CNVs (see all 28): 59600 77628 49872 72953 34570 8850 77630 88499 38843 0502 4038 88496 49870 77629 49871
1 Inversion: 37194 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL17B |
|
Disorders
/ Diseases
for ARL17B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARL17B for disorders About GeneDecksing
1  disease for ARL17B: About MalaCardscholera
Export disorders for ARL17B gene to outside databases
|
Publications
for ARL17B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARL17B gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARL17B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)1 Choudhary C.... Mann M. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for ARL17B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ARL17B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARL17B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARL17B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARL17B | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ARL17B gene:
Search GeneIP for patents involving ARL17B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARL17B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARL17B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL17B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL17B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL17B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL17B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL17B |
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| | | | Search Tocris compounds for ARL17B |
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 | | | ARL17B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL17B |
|  |  |  | | | | Search ThermoFisher Antibodies for ARL17B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARL17B |
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