ARL17A Gene
protein-coding GIFtS: 36
GCID: GC17M044595
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ADP-ribosylation factor-like 17A(Previous names: ADP-ribosylation factor 1 pseudogene 2, ADP-ribosylation...)
(Previous symbols: ARF1P2, ARL17P1)
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Aliases
for ARL17A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADP-Ribosylation Factor-Like 17A1 2 | | ADP-Ribosylation Factor-Like 17 Pseudogene 11 2 | | ARF1P21 2 3 | | ADP-Ribosylation Factor 72 | | ARL17P11 2 3 | | ADP-Ribosylation Factor-Like 17-Like2 | | ADP-Ribosylation Factor 1 Pseudogene 21 2 | | ADP-Ribosylation Factor 7 Variant3 |
Export aliases for ARL17A gene to outside databasesPrevious GC identifer: GC17Pp43776 |
Summaries
for ARL17A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ARL17_HUMAN, Q8IVW1Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, anADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgiapparatus (By similarity)
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Genomic Views
for ARL17A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ARL17A
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARL17A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL17A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q21.31 Ensembl cytogenetic band: 17q21.31 HGNC cytogenetic band: 17q21.31ARL17A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M044595: view genomic region
(about GC identifiers)
Start:
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44,594,068 bp from pter |
End:
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44,657,088 bp from pter |
Size:
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63,021 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr17+,ALT_REF_LOCI_9 43,776,446-43,839,462 |
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Proteins
for ARL17A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARL17_HUMAN, Q8IVW1 (See
protein sequence)Recommended Name: ADP-ribosylation factor-like protein 17 Size: 177 amino acids; 19388 Da
Subcellular location: Golgi apparatus (By similarity)
Sequence caution: Sequence=AAF64278.1; Type=Frameshift; Positions=114; Sequence=AAF69643.1; Type=Frameshift;Positions=17; Sequence=AAH30570.1; Type=Erroneous initiation; Sequence=BAD92581.1; Type=Erroneous initiation;
Secondary accessions: B0AZR6 Q59FW5 Q8N6E2 Q8TD73 Q8WW54 Q9NZD5 Q9P158Alternative splicing: 3 isoforms: Q8IVW1-1 Q8IVW1-2 Q8IVW1-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARL17A: NX_Q8IVW1
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IVW1
ARL17A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001107210.1 NP_057716.2
ENSEMBL proteins: ENSP00000416535 ENSP00000459759 ENSP00000459606 ENSP00000337478 ENSP00000331563 ENSP00000338611
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ARL17A for ontologies About GeneDecksing
ARL17A Antibody Products:
Assay Products for ARL17A: |
Protein
Domains /
Families
for ARL17A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARL17A for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IVW1ProtoNet protein and cluster: Q8IVW1 1 Blocks protein family: IPB006688 ADP-ribosylation factor
UniProtKB/Swiss-Prot: ARL17_HUMAN, Q8IVW1Similarity: Belongs to the small GTPase superfamily. Arf family |
Function
for ARL17A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARL17_HUMAN, Q8IVW1Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, anADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgiapparatus (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL17A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL17A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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Synthesis Service for ARL17A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL17A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL17A |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005525 | GTP binding |
-- | -- |
ARL17A for ontologies About GeneDecksing
|
Pathways & Interactions
for ARL17A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL17A
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
-- | -- | | GO:0015031 | protein transport |
-- | -- | | GO:0016192 | vesicle-mediated transport |
-- | -- |
ARL17A for ontologies About GeneDecksing
|
Drugs & Compounds
for ARL17A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARL17A
1 HMDB Compound for ARL17A About this table
Search CenterWatch for drugs/clinical trials and news about ARL17A / ARL17
|
Transcripts
for ARL17A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARL17A gene (2 alternative transcripts): NM_001113738.1 NM_016632.2 6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000445552 ENST00000573185 ENST00000570550 ENST00000336125(uc002iks.2)
ENST00000329240 ENST00000337845(uc002iko.4 uc010wkd.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL17A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL17A (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ARL17A (NM_001113738) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARL17A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL17A |
24/175 AceView cDNA sequences (see all 175): CR620290 CR624169 BX103170 BC000924 AF493886 BU623906 BE697113 CA449330 AI457277 AA042906 BU736178 CB158582 AA042918 CA398126 AA371155 BQ069419 BX504248 BE348638 BV203418 AL698217 BQ003307 BP872450 BV205364 BV203415
GeneLoc Exon Structure
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Expression
for ARL17A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARL17A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ARL17A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARL17A
SABiosciences Custom PCR Arrays for ARL17A
Primer
Products: | | Browse OriGene genome-wide validated SYBR primer pairs
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ARL17A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL17A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL17A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL17A |
Orthologs
for ARL17A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ARL17A (if available)
TreeFam Gene Tree for ARL17A (if available) |
Paralogs
for ARL17A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARL17A gene
13 SIMAP similar genes for ARL17A using alignment to 4 protein entries: ARL17_HUMAN (see all proteins):ARL17 ARL17B ARF1 ARF3 NBR2 ARL1
ARF5 ARF6 ARF4 ARL5B ARL6 ARL5A
SAR1B
ARL17A for paralogs About GeneDecksing
5/11 Pseudogenes.org Pseudogenes for ARL17A (see all 11)
PGOHUM00000237022 PGOHUM00000237064 PGOHUM00000237096 PGOHUM00000237354 PGOHUM00000237360
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Genomic Variants
for ARL17A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARL17A (44594068 - 44657088 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 43 variations for ARL17A
15/42 CNVs (see all 42): 88502 49872 72957 8850 77630 4038 0803 2228 88497 72954 2227 72958 37635 32184 88500
1 Inversion: 37194 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL17A |
|
Disorders
/ Diseases
for ARL17A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARL17A for disorders About GeneDecksing
10  diseases for ARL17A: About MalaCardsbardet-biedl syndrome retinitis pigmentosa epithelial ovarian cancer familial breast cancer
ovarian cancer breast cancer cholera retinitis
ischemia carcinoma
Export disorders for ARL17A gene to outside databases
|
Publications
for ARL17A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARL17A gene, integrated from 9 sources (see all 13):
(articles sorted by number of sources associating them with ARL17A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Comparative genomic analysis identifies an ADP-ribosylation factor- like gene as the cause of Bardet-Biedl Syndrome (BBS3). (PubMed id 15258860)9 Chiang A.P....Sheffield V.C. (2004)
- Expression of an ADP-ribosylation factor like gene, ARF4L, is induced after transient forebrain ischemia in the gerbil. (PubMed id 9602063)9 Katayama T....Tohyama M. (1998)
- The Structure of Binder of Arl2 (BART) Reveals a Novel G Protein Binding Domain: IMPLICATIONS FOR FUNCTION. (PubMed id 18981177)9 Bailey L.K....Mott H.R. (2009)
- [Effects of ARLTS1 gene on growth and apoptosis of epithelial ovarian cancer SKOV3 cells] (PubMed id 19292033)9 Yang X.Y....Peng Z.L. (2009)
- ARLTS1 - a novel tumor suppressor gene. (PubMed id 18375053)9 Yendamuri S....Calin G.A. (2008)
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External Searches for ARL17A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARL17A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARL17A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARL17A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARL17A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARL17A gene:
Search GeneIP for patents involving ARL17A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARL17A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARL17A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL17A | | Browse OriGene genome-wide validated SYBR primer pairs | | | OriGene Protein Over-expression Lysate for ARL17A | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ARL17A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL17A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL17A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARL17A | | OriGene Custom Protein Services for ARL17A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARL17A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL17A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL17A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL17A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL17A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL17A |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL17A |
|  |  |  | | | | Search ThermoFisher Antibodies for ARL17A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL17A |
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