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Aliases for ARL17A Gene

Aliases for ARL17A Gene

  • ADP Ribosylation Factor Like GTPase 17A 2 3 5
  • ARL17P1 3 4
  • ARF1P2 3 4
  • ADP-Ribosylation Factor-Like 17 Pseudogene 1 2
  • ADP-Ribosylation Factor Like GTPase 17A 2
  • ADP-Ribosylation Factor-Like Protein 17 3
  • ADP-Ribosylation Factor 1 Pseudogene 2 2
  • ADP-Ribosylation Factor 7 Variant 4
  • ADP-Ribosylation Factor 7 3
  • ARL17A ARL17B 4

External Ids for ARL17A Gene

Previous HGNC Symbols for ARL17A Gene

  • ARF1P2
  • ARL17P1

Previous GeneCards Identifiers for ARL17A Gene

  • GC17Pp43776
  • GC17M044595

Summaries for ARL17A Gene

GeneCards Summary for ARL17A Gene

ARL17A (ADP Ribosylation Factor Like GTPase 17A) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL17B.

UniProtKB/Swiss-Prot for ARL17A Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL17A Gene

Genomics for ARL17A Gene

Regulatory Elements for ARL17A Gene

Enhancers for ARL17A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARL17A on UCSC Golden Path with GeneCards custom track

Promoters for ARL17A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARL17A on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL17A Gene

Chromosome:
17
Start:
46,499,818 bp from pter
End:
46,579,792 bp from pter
Size:
79,975 bases
Orientation:
Minus strand

Genomic View for ARL17A Gene

Genes around ARL17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL17A Gene

Proteins for ARL17A Gene

  • Protein details for ARL17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVW1-ARL17_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 17
    Protein Accession:
    Q8IVW1
    Secondary Accessions:
    • B0AZR6
    • Q59FW5
    • Q8N6E2
    • Q8TD73
    • Q8WW54
    • Q9NZD5
    • Q9P158

    Protein attributes for ARL17A Gene

    Size:
    177 amino acids
    Molecular mass:
    19388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF64278.1; Type=Frameshift; Positions=114; Evidence={ECO:0000305}; Sequence=AAF69643.1; Type=Frameshift; Positions=17; Evidence={ECO:0000305}; Sequence=AAH30570.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92581.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARL17A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL17A Gene

Proteomics data for ARL17A Gene at MOPED

Post-translational modifications for ARL17A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARL17A Gene

Domains & Families for ARL17A Gene

Gene Families for ARL17A Gene

Protein Domains for ARL17A Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVW1

UniProtKB/Swiss-Prot:

ARL17_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL17A: view

No data available for Suggested Antigen Peptide Sequences for ARL17A Gene

Function for ARL17A Gene

Molecular function for ARL17A Gene

UniProtKB/Swiss-Prot Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

Phenotypes for ARL17A Gene

GenomeRNAi human phenotypes for ARL17A:
genes like me logo Genes that share phenotypes with ARL17A: view

Animal Model Products

CRISPR Products

miRNA for ARL17A Gene

miRTarBase miRNAs that target ARL17A

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL17A Gene

Localization for ARL17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL17A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL17A Gene COMPARTMENTS Subcellular localization image for ARL17A gene
Compartment Confidence
golgi apparatus 3

No data available for Gene Ontology (GO) - Cellular Components for ARL17A Gene

Pathways & Interactions for ARL17A Gene

SuperPathways for ARL17A Gene

No Data Available

Interacting Proteins for ARL17A Gene

Gene Ontology (GO) - Biological Process for ARL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL17A: view

No data available for Pathways by source and SIGNOR curated interactions for ARL17A Gene

Drugs & Compounds for ARL17A Gene

(1) Drugs for ARL17A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARL17A: view

Transcripts for ARL17A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ARL17A Gene

No ASD Table

Relevant External Links for ARL17A Gene

GeneLoc Exon Structure for
ARL17A
ECgene alternative splicing isoforms for
ARL17A

Expression for ARL17A Gene

mRNA expression in normal human tissues for ARL17A Gene

Protein differential expression in normal tissues from HIPED for ARL17A Gene

This gene is overexpressed in Cerebrospinal fluid (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL17A Gene



genes like me logo Genes that share expression patterns with ARL17A: view

Protein tissue co-expression partners for ARL17A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARL17A Gene

Orthologs for ARL17A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ARL17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
Species with no ortholog for ARL17A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARL17A Gene

ENSEMBL:
Gene Tree for ARL17A (if available)
TreeFam:
Gene Tree for ARL17A (if available)

Paralogs for ARL17A Gene

Paralogs for ARL17A Gene

(13) SIMAP similar genes for ARL17A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARL17A: view

Variants for ARL17A Gene

Sequence variations from dbSNP and Humsavar for ARL17A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_017170 -
rs1397948 -- 46,566,783(+) AGCCT(C/T)TCTTC intron-variant
rs2941972 -- 46,581,503(+) CACCG(A/C)GCCTG upstream-variant-2KB
rs2941974 -- 46,569,893(-) CCGGC(C/T)TGCGT intron-variant
rs2667878 -- 46,571,000(+) TCAAA(C/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL17A Gene

Variant ID Type Subtype PubMed ID
dgv127e55 CNV Gain 17911159
nsv471698 CNV Gain+Loss 15918152
dgv972e1 CNV Complex 17122850
dgv973e1 CNV Complex 17122850
dgv974e1 CNV Complex 17122850
dgv975e1 CNV Complex 17122850
dgv976e1 CNV Complex 17122850
nsv516807 CNV Gain+Loss 19592680
dgv3183n71 CNV Gain 21882294
nsv908315 CNV Gain 21882294
nsv821687 CNV Gain 15273396
dgv977e1 CNV Complex 17122850
esv33048 CNV Gain+Loss 17666407
nsv9564 CNV Gain+Loss 18304495
esv21783 CNV Gain+Loss 19812545
dgv978e1 CNV Complex 17122850
nsv469697 CNV Complex 16826518
dgv982e1 CNV Complex 17122850
esv2656635 CNV Deletion 23128226
nsv908326 CNV Gain 21882294
nsv908327 CNV Loss 21882294
dgv3185n71 CNV Gain 21882294
nsv908329 CNV Gain 21882294
dgv13n31 CNV Duplication 19718026
nsv2070 CNV Loss 18451855
nsv511057 CNV Complex 20534489
dgv3186n71 CNV Loss 21882294
nsv163 CNV Loss 15895083
dgv3187n71 CNV Gain 21882294
nsv821581 CNV Deletion 20802225
nsv908334 CNV Gain+Loss 21882294
dgv3188n71 CNV Gain 21882294
dgv983e1 CNV Complex 17122850
dgv984e1 CNV Complex 17122850
dgv985e1 CNV Complex 17122850
nsv428343 CNV Gain+Loss 18775914
nsv442749 CNV CNV 18776908
dgv3189n71 CNV Loss 21882294
dgv3190n71 CNV Gain+Loss 21882294
dgv3191n71 CNV Loss 21882294
dgv3192n71 CNV Gain+Loss 21882294
dgv3193n71 CNV Gain 21882294
dgv3194n71 CNV Loss 21882294
dgv3195n71 CNV Gain+Loss 21882294
dgv3196n71 CNV Gain 21882294
esv1003686 CNV Gain 20482838
dgv3197n71 CNV Gain 21882294
dgv3198n71 CNV Gain 21882294
esv2421412 OTHER Complex 20811451
dgv15n14 CNV Loss 18776910
nsv819319 CNV Loss 19587683
dgv3199n71 CNV Gain+Loss 21882294
dgv3200n71 CNV Loss 21882294
dgv3201n71 CNV Loss 21882294
dgv3205n71 CNV Loss 21882294
nsv833463 CNV Loss 17160897
dgv3211n71 CNV Loss 21882294
nsv908530 CNV Loss 21882294
nsv510715 CNV Loss 20534489
nsv908532 CNV Gain 21882294
dgv14n31 CNV Duplication 19718026
nsv433450 CNV Gain 18776910
nsv433451 CNV Gain 18776910
nsv469644 CNV Complex 16826518
nsv471700 CNV Gain+Loss 15918152
nsv820933 CNV Deletion 20802225
nsv833464 CNV Gain 17160897
nsv908533 CNV Gain 21882294
dgv3214n71 CNV Gain+Loss 21882294
dgv3215n71 CNV Loss 21882294
dgv3216n71 CNV Gain 21882294
nsv471401 CNV Complex 19718026
nsv482202 CNV Gain 20164927
nsv908538 CNV Loss 21882294
dgv3217n71 CNV Loss 21882294
dgv3218n71 CNV Gain+Loss 21882294
dgv3219n71 CNV Gain+Loss 21882294
dgv3220n71 CNV Gain+Loss 21882294
nsv471514 CNV Duplication 19718026
dgv3221n71 CNV Gain 21882294
dgv16n14 CNV Loss 18776910

Relevant External Links for ARL17A Gene

HapMap Linkage Disequilibrium report
ARL17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ARL17A Gene

Disorders for ARL17A Gene

Relevant External Links for ARL17A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL17A

No disorders were found for ARL17A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL17A Gene

Publications for ARL17A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function. (PMID: 18981177) Bailey L.K. … Mott H.R. (J. Biol. Chem. 2009) 23
  5. [Effects of ARLTS1 gene on growth and apoptosis of epithelial ovarian cancer SKOV3 cells]. (PMID: 19292033) Yang X.Y. … Peng Z.L. (Sichuan Da Xue Xue Bao Yi Xue Ban 2009) 23

Products for ARL17A Gene

Sources for ARL17A Gene

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