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Aliases for ARL17A Gene

Aliases for ARL17A Gene

  • ADP-Ribosylation Factor-Like 17A 2 3
  • ADP-Ribosylation Factor-Like 17 Pseudogene 1 2 3
  • ADP-Ribosylation Factor 1 Pseudogene 2 2 3
  • ARL17P1 3 4
  • ARF1P2 3 4
  • ADP-Ribosylation Factor-Like 17-Like 3
  • ADP-Ribosylation Factor 7 Variant 4
  • ADP-Ribosylation Factor 7 3
  • ARL17A ARL17B 4

External Ids for ARL17A Gene

Previous Symbols for ARL17A Gene

  • ARF1P2
  • ARL17P1

Summaries for ARL17A Gene

GeneCards Summary for ARL17A Gene

ARL17A (ADP-Ribosylation Factor-Like 17A) is a Protein Coding gene. Diseases associated with ARL17A include familial breast cancer and bardet-biedl syndrome. An important paralog of this gene is ARL17B.

UniProtKB/Swiss-Prot for ARL17A Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL17A Gene

Genomics for ARL17A Gene

Genomic Location for ARL17A Gene

Start:
46,499,818 bp from pter
End:
46,579,786 bp from pter
Size:
79,969 bases
Orientation:
Minus strand

Genomic View for ARL17A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL17A Gene

No data available for Regulatory Elements for ARL17A Gene

Proteins for ARL17A Gene

  • Protein details for ARL17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVW1-ARL17_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 17
    Protein Accession:
    Q8IVW1
    Secondary Accessions:
    • B0AZR6
    • Q59FW5
    • Q8N6E2
    • Q8TD73
    • Q8WW54
    • Q9NZD5
    • Q9P158

    Protein attributes for ARL17A Gene

    Size:
    177 amino acids
    Molecular mass:
    19388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF64278.1; Type=Frameshift; Positions=114; Evidence={ECO:0000305}; Sequence=AAF69643.1; Type=Frameshift; Positions=17; Evidence={ECO:0000305}; Sequence=AAH30570.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92581.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARL17A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL17A Gene

Proteomics data for ARL17A Gene at MOPED

Post-translational modifications for ARL17A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARL17A Gene

Domains for ARL17A Gene

Gene Families for ARL17A Gene

HGNC:
  • ARL :ADP-ribosylation factors-like
  • ARF :ADP-ribosylation factors

Protein Domains for ARL17A Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVW1

UniProtKB/Swiss-Prot:

ARL17_HUMAN
Family:
  • Belongs to the small GTPase superfamily. Arf family.:
    • Q8IVW1
genes like me logo Genes that share domains with ARL17A: view

No data available for Suggested Antigen Peptide Sequences for ARL17A Gene

Function for ARL17A Gene

Molecular function for ARL17A Gene

UniProtKB/Swiss-Prot Function: GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

Gene Ontology (GO) - Molecular Function for ARL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding --
genes like me logo Genes that share ontologies with ARL17A: view

miRNA for ARL17A Gene

miRTarBase miRNAs that target ARL17A

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARL17A Gene

Localization for ARL17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL17A Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL17A Gene COMPARTMENTS Subcellular localization image for ARL17A gene
Compartment Confidence
cytosol 3
extracellular 2
golgi apparatus 2
endoplasmic reticulum 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005794 Golgi apparatus --
genes like me logo Genes that share ontologies with ARL17A: view

Pathways for ARL17A Gene

SuperPathways for ARL17A Gene

No Data Available

Interacting Proteins for ARL17A Gene

Gene Ontology (GO) - Biological Process for ARL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction --
GO:0015031 protein transport --
GO:0016192 vesicle-mediated transport --
genes like me logo Genes that share ontologies with ARL17A: view

No data available for Pathways by source for ARL17A Gene

Compounds for ARL17A Gene

(1) HMDB Compounds for ARL17A Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ARL17A: view

Transcripts for ARL17A Gene

Alternative Splicing Database (ASD) splice patterns (SP) for ARL17A Gene

No ASD Table

Relevant External Links for ARL17A Gene

GeneLoc Exon Structure for
ARL17A
ECgene alternative splicing isoforms for
ARL17A

Expression for ARL17A Gene

mRNA expression in normal human tissues for ARL17A Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARL17A Gene

genes like me logo Genes that share expressions with ARL17A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARL17A Gene

Orthologs for ARL17A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ARL17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
ManyToMany
-- 36
  • 81 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
Species with no ortholog for ARL17A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARL17A Gene

ENSEMBL:
Gene Tree for ARL17A (if available)
TreeFam:
Gene Tree for ARL17A (if available)

Paralogs for ARL17A Gene

Paralogs for ARL17A Gene

Selected SIMAP similar genes for ARL17A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARL17A: view

Variants for ARL17A Gene

Sequence variations from dbSNP and Humsavar for ARL17A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1397948 -- 46,566,783(+) AGCCT(C/T)TCTTC intron-variant
rs2941972 -- 46,581,503(+) CACCG(A/C)GCCTG upstream-variant-2KB
rs3106343 -- 46,557,861(+) TCACT(A/G)GCTGG intron-variant
rs3107501 -- 46,557,794(-) TCCCC(A/G)CCTTC intron-variant
rs3110589 -- 46,557,805(-) CCACC(A/G)TAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL17A Gene

Variant ID Type Subtype PubMed ID
dgv127e55 CNV Gain 17911159
nsv471698 CNV Gain+Loss 15918152
dgv972e1 CNV Complex 17122850
dgv973e1 CNV Complex 17122850
dgv974e1 CNV Complex 17122850
dgv975e1 CNV Complex 17122850
dgv976e1 CNV Complex 17122850
nsv516807 CNV Gain+Loss 19592680
dgv3183n71 CNV Gain 21882294
nsv908315 CNV Gain 21882294
nsv821687 CNV Gain 15273396
dgv977e1 CNV Complex 17122850
esv33048 CNV Gain+Loss 17666407
nsv9564 CNV Gain+Loss 18304495
esv21783 CNV Gain+Loss 19812545
dgv978e1 CNV Complex 17122850
nsv469697 CNV Complex 16826518
dgv982e1 CNV Complex 17122850
esv2656635 CNV Deletion 23128226
nsv908326 CNV Gain 21882294
nsv908327 CNV Loss 21882294
dgv3185n71 CNV Gain 21882294
nsv908329 CNV Gain 21882294
dgv13n31 CNV Duplication 19718026
nsv2070 CNV Loss 18451855
nsv511057 CNV Complex 20534489
dgv3186n71 CNV Loss 21882294
nsv163 CNV Loss 15895083
dgv3187n71 CNV Gain 21882294
nsv821581 CNV Deletion 20802225
nsv908334 CNV Gain+Loss 21882294
dgv3188n71 CNV Gain 21882294
dgv983e1 CNV Complex 17122850
dgv984e1 CNV Complex 17122850
dgv985e1 CNV Complex 17122850
nsv428343 CNV Gain+Loss 18775914
nsv442749 CNV CNV 18776908
dgv3189n71 CNV Loss 21882294
dgv3190n71 CNV Gain+Loss 21882294
dgv3191n71 CNV Loss 21882294
dgv3192n71 CNV Gain+Loss 21882294
dgv3193n71 CNV Gain 21882294
dgv3194n71 CNV Loss 21882294
dgv3195n71 CNV Gain+Loss 21882294
dgv3196n71 CNV Gain 21882294
esv1003686 CNV Gain 20482838
dgv3197n71 CNV Gain 21882294
dgv3198n71 CNV Gain 21882294
esv2421412 OTHER Complex 20811451
dgv15n14 CNV Loss 18776910
nsv819319 CNV Loss 19587683
dgv3199n71 CNV Gain+Loss 21882294
dgv3200n71 CNV Loss 21882294
dgv3201n71 CNV Loss 21882294
dgv3205n71 CNV Loss 21882294
nsv833463 CNV Loss 17160897
dgv3211n71 CNV Loss 21882294
nsv908530 CNV Loss 21882294
nsv510715 CNV Loss 20534489
nsv908532 CNV Gain 21882294
dgv14n31 CNV Duplication 19718026
nsv433450 CNV Gain 18776910
nsv433451 CNV Gain 18776910
nsv469644 CNV Complex 16826518
nsv471700 CNV Gain+Loss 15918152
nsv820933 CNV Deletion 20802225
nsv833464 CNV Gain 17160897
nsv908533 CNV Gain 21882294
dgv3214n71 CNV Gain+Loss 21882294
dgv3215n71 CNV Loss 21882294
dgv3216n71 CNV Gain 21882294
nsv471401 CNV Complex 19718026
nsv482202 CNV Gain 20164927
nsv908538 CNV Loss 21882294
dgv3217n71 CNV Loss 21882294
dgv3218n71 CNV Gain+Loss 21882294
dgv3219n71 CNV Gain+Loss 21882294
dgv3220n71 CNV Gain+Loss 21882294
nsv471514 CNV Duplication 19718026
dgv3221n71 CNV Gain 21882294
dgv16n14 CNV Loss 18776910

Relevant External Links for ARL17A Gene

HapMap Linkage Disequilibrium report
ARL17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL17A Gene

Disorders for ARL17A Gene

genes like me logo Genes that share disorders with ARL17A: view

No data available for UniProtKB/Swiss-Prot for ARL17A Gene

Publications for ARL17A Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PMID: 22505724) Udeshi N.D. … Carr S.A. (Mol. Cell Proteomics 2012) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4

Products for ARL17A Gene

Sources for ARL17A Gene

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