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Aliases for ARL17A Gene

Aliases for ARL17A Gene

  • ADP Ribosylation Factor Like GTPase 17A 2 3 5
  • ARL17P1 3 4
  • ARF1P2 3 4
  • ADP-Ribosylation Factor-Like 17 Pseudogene 1 2
  • ADP-Ribosylation Factor Like GTPase 17A 2
  • ADP-Ribosylation Factor-Like Protein 17 3
  • ADP-Ribosylation Factor 1 Pseudogene 2 2
  • ADP-Ribosylation Factor-Like 17-Like 3
  • ADP-Ribosylation Factor 7 Variant 4
  • ADP-Ribosylation Factor 7 3
  • ARL17A ARL17B 4

External Ids for ARL17A Gene

Previous HGNC Symbols for ARL17A Gene

  • ARF1P2
  • ARL17P1

Previous GeneCards Identifiers for ARL17A Gene

  • GC17Pp43776
  • GC17M044595

Summaries for ARL17A Gene

GeneCards Summary for ARL17A Gene

ARL17A (ADP Ribosylation Factor Like GTPase 17A) is a Protein Coding gene. Diseases associated with ARL17A include Bardet-Biedl Syndrome. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL17B.

UniProtKB/Swiss-Prot for ARL17A Gene

  • GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL17A Gene

Genomics for ARL17A Gene

Regulatory Elements for ARL17A Gene

Enhancers for ARL17A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ARL17A on UCSC Golden Path with GeneCards custom track

Promoters for ARL17A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARL17A on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL17A Gene

Chromosome:
17
Start:
46,499,818 bp from pter
End:
46,579,792 bp from pter
Size:
79,975 bases
Orientation:
Minus strand

Genomic View for ARL17A Gene

Genes around ARL17A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL17A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL17A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL17A Gene

Proteins for ARL17A Gene

  • Protein details for ARL17A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVW1-ARL17_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 17
    Protein Accession:
    Q8IVW1
    Secondary Accessions:
    • B0AZR6
    • Q59FW5
    • Q8N6E2
    • Q8TD73
    • Q8WW54
    • Q9NZD5
    • Q9P158

    Protein attributes for ARL17A Gene

    Size:
    177 amino acids
    Molecular mass:
    19388 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF64278.1; Type=Frameshift; Positions=114; Evidence={ECO:0000305}; Sequence=AAF69643.1; Type=Frameshift; Positions=17; Evidence={ECO:0000305}; Sequence=AAH30570.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92581.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARL17A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL17A Gene

Post-translational modifications for ARL17A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARL17A Gene

Domains & Families for ARL17A Gene

Gene Families for ARL17A Gene

Protein Domains for ARL17A Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVW1

UniProtKB/Swiss-Prot:

ARL17_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL17A: view

No data available for Suggested Antigen Peptide Sequences for ARL17A Gene

Function for ARL17A Gene

Molecular function for ARL17A Gene

UniProtKB/Swiss-Prot Function:
GTP-binding protein that functions as an allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus (By similarity).

Phenotypes for ARL17A Gene

GenomeRNAi human phenotypes for ARL17A:
genes like me logo Genes that share phenotypes with ARL17A: view

Animal Model Products

CRISPR Products

miRNA for ARL17A Gene

miRTarBase miRNAs that target ARL17A

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL17A Gene

Localization for ARL17A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL17A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL17A Gene COMPARTMENTS Subcellular localization image for ARL17A gene
Compartment Confidence
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for ARL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with ARL17A: view

Pathways & Interactions for ARL17A Gene

SuperPathways for ARL17A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL17A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ARL17A: view

No data available for Pathways by source and SIGNOR curated interactions for ARL17A Gene

Drugs & Compounds for ARL17A Gene

(1) Drugs for ARL17A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARL17A: view

Transcripts for ARL17A Gene

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL17A Gene

No ASD Table

Relevant External Links for ARL17A Gene

GeneLoc Exon Structure for
ARL17A
ECgene alternative splicing isoforms for
ARL17A

Expression for ARL17A Gene

mRNA expression in normal human tissues for ARL17A Gene

Protein differential expression in normal tissues from HIPED for ARL17A Gene

This gene is overexpressed in Cerebrospinal fluid (67.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL17A Gene



Protein tissue co-expression partners for ARL17A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL17A Gene:

ARL17A
genes like me logo Genes that share expression patterns with ARL17A: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARL17A Gene

Orthologs for ARL17A Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ARL17A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
ManyToMany
-- 35
  • 81 (a)
ManyToMany
-- 35
  • 76 (a)
ManyToMany
Species where no ortholog for ARL17A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARL17A Gene

ENSEMBL:
Gene Tree for ARL17A (if available)
TreeFam:
Gene Tree for ARL17A (if available)

Paralogs for ARL17A Gene

Paralogs for ARL17A Gene

(13) SIMAP similar genes for ARL17A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARL17A: view

Variants for ARL17A Gene

Sequence variations from dbSNP and Humsavar for ARL17A Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_017170 -
rs1397948 -- 46,566,783(+) AGCCT(C/T)TCTTC intron-variant
rs2667878 -- 46,571,000(+) TCAAA(C/G)AGAAT intron-variant
rs2667905 -- 46,561,354(-) TGCTG(C/T)ATAAT intron-variant
rs4630592 -- 46,577,050(+) TTATA(A/C/G/T)TGCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL17A Gene

Variant ID Type Subtype PubMed ID
dgv127e55 CNV gain 17911159
dgv13n31 CNV gain 19718026
dgv14n31 CNV gain 19718026
dgv15n14 CNV loss 18776910
dgv16n14 CNV loss 18776910
dgv1773e59 CNV duplication 20981092
dgv29e213 CNV loss 24956385
dgv30e213 CNV gain 24956385
dgv3185n100 CNV gain 25217958
dgv3188n100 CNV gain 25217958
dgv3189n100 CNV gain 25217958
dgv3190n100 CNV gain 25217958
dgv3196n100 CNV gain+loss 25217958
dgv3198n100 CNV loss 25217958
dgv3206n100 CNV loss 25217958
dgv3214n100 CNV gain+loss 25217958
dgv3232n100 CNV loss 25217958
dgv3233n100 CNV gain 25217958
dgv3239n100 CNV gain 25217958
dgv3240n100 CNV gain 25217958
dgv3241n100 CNV loss 25217958
dgv3242n100 CNV gain+loss 25217958
dgv3245n100 CNV gain+loss 25217958
dgv3246n100 CNV gain+loss 25217958
dgv3247n100 CNV gain 25217958
dgv3248n100 CNV loss 25217958
dgv3249n100 CNV gain 25217958
dgv3250n100 CNV gain+loss 25217958
dgv3251n100 CNV loss 25217958
dgv3252n100 CNV loss 25217958
dgv3253n100 CNV loss 25217958
dgv3254n100 CNV gain+loss 25217958
dgv3255n100 CNV gain 25217958
dgv3256n100 CNV loss 25217958
dgv3257n100 CNV loss 25217958
dgv3258n100 CNV gain+loss 25217958
dgv3259n100 CNV loss 25217958
dgv3260n100 CNV loss 25217958
dgv5623n54 CNV loss 21841781
dgv5628n54 CNV loss 21841781
dgv5641n54 CNV loss 21841781
dgv5642n54 CNV loss 21841781
dgv5643n54 CNV gain 21841781
dgv5644n54 CNV gain 21841781
dgv5645n54 CNV loss 21841781
dgv5646n54 CNV gain+loss 21841781
dgv5647n54 CNV loss 21841781
dgv5648n54 CNV gain+loss 21841781
dgv5649n54 CNV loss 21841781
dgv5650n54 CNV gain 21841781
dgv5651n54 CNV loss 21841781
dgv5656n54 CNV loss 21841781
dgv5657n54 CNV loss 21841781
dgv5658n54 CNV loss 21841781
dgv5659n54 CNV loss 21841781
dgv5660n54 CNV gain+loss 21841781
dgv939e212 CNV gain 25503493
dgv940e212 CNV loss 25503493
esv1003686 CNV gain 20482838
esv21783 CNV gain+loss 19812545
esv2421412 OTHER complex 20811451
esv2656635 CNV deletion 23128226
esv2758692 CNV gain+loss 17122850
esv2760451 CNV gain+loss 21179565
esv2762433 CNV gain+loss 21179565
esv33048 CNV gain+loss 17666407
esv3359586 CNV duplication 20981092
esv3411572 CNV duplication 20981092
esv3430044 CNV duplication 20981092
esv3893017 CNV gain+loss 25118596
esv3893019 CNV gain+loss 25118596
esv3893020 CNV gain 25118596
esv3893021 CNV gain 25118596
esv3893023 CNV gain+loss 25118596
esv3893024 CNV gain 25118596
nsv1061687 CNV loss 25217958
nsv1063349 CNV gain 25217958
nsv1063380 CNV gain 25217958
nsv1070410 CNV deletion 25765185
nsv1072741 CNV deletion 25765185
nsv1126463 CNV deletion 24896259
nsv1133408 CNV deletion 24896259
nsv1136238 CNV deletion 24896259
nsv1146669 OTHER inversion 26484159
nsv1160494 CNV deletion 26073780
nsv163 CNV deletion 15895083
nsv2070 CNV deletion 18451855
nsv428343 CNV gain+loss 18775914
nsv433450 CNV gain 18776910
nsv433451 CNV gain 18776910
nsv442749 CNV gain+loss 18776908
nsv469644 CNV gain+loss 16826518
nsv471401 CNV gain+loss 19718026
nsv471514 CNV gain 19718026
nsv471700 CNV gain+loss 15918152
nsv482202 CNV gain 20164927
nsv510715 CNV deletion 20534489
nsv511057 OTHER complex 20534489
nsv516807 CNV gain+loss 19592680
nsv575266 CNV gain 21841781
nsv575272 CNV loss 21841781
nsv575314 CNV gain+loss 21841781
nsv575369 CNV loss 21841781
nsv575387 CNV gain+loss 21841781
nsv575388 CNV gain 21841781
nsv575389 CNV loss 21841781
nsv819319 CNV loss 19587683
nsv820933 CNV deletion 20802225
nsv821581 CNV deletion 20802225
nsv821687 CNV gain 15273396
nsv833463 CNV loss 17160897
nsv833464 CNV gain 17160897
nsv953915 CNV deletion 24416366
nsv953916 CNV duplication 24416366
nsv9564 CNV gain+loss 18304495
nsv960494 CNV duplication 23825009
nsv960495 CNV duplication 23825009
nsv960604 CNV duplication 23825009
nsv978553 CNV duplication 23825009

Relevant External Links for ARL17A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL17A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for ARL17A Gene

Disorders for ARL17A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARL17A Gene - From: GeneCards

Disorder Aliases PubMed IDs
bardet-biedl syndrome
  • laurence-moon syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARL17A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL17A
genes like me logo Genes that share disorders with ARL17A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL17A Gene

Publications for ARL17A Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function. (PMID: 18981177) Bailey L.K. … Mott H.R. (J. Biol. Chem. 2009) 22 65
  5. [Effects of ARLTS1 gene on growth and apoptosis of epithelial ovarian cancer SKOV3 cells]. (PMID: 19292033) Yang X.Y. … Peng Z.L. (Sichuan Da Xue Xue Bao Yi Xue Ban 2009) 22 65

Products for ARL17A Gene

Sources for ARL17A Gene

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