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ARL16 Gene

protein-coding   GIFtS: 40
GCID: GC17M079649

ADP-Ribosylation Factor-Like 16

  Search for ARL16
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 161 2
ADP-Ribosylation Factor-Like Protein 162

External Ids:    HGNC: 279021   Entrez Gene: 3392312   Ensembl: ENSG000002140877   UniProtKB: Q0P5N63   

Export aliases for ARL16 gene to outside databases

Previous GC identifers: GC17M077259 GC17M075094


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARL16 Gene:
ARL16 (ADP-ribosylation factor-like 16) is a protein-coding gene. GO annotations related to this gene include GTP binding.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000017.11  NC_018928.2  NT_010783.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL16 gene promoter:
         Elk-1   AML1a   Lmo2   AP-4   Roaz   PPAR-gamma1   CP2   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for ARL16

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

ARL16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL16 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079649:  view genomic region     (about GC identifiers)

Start:
79,648,204 bp from pter      End:
79,650,954 bp from pter
Size:
2,751 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARL16_HUMAN, Q0P5N6 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 16  
Size: 197 amino acids; 20936 Da

Explore the universe of human proteins at neXtProt for ARL16: NX_Q0P5N6

Explore proteomics data for ARL16 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARL16 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001035114.1  
    ENSEMBL proteins: 
     ENSP00000380635   ENSP00000458672   ENSP00000460198   ENSP00000459201   ENSP00000461674  
     ENSP00000458980   ENSP00000461661  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry Q0P5N6

    ProtoNet protein and cluster: Q0P5N6

    UniProtKB/Swiss-Prot: ARL16_HUMAN, Q0P5N6
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--
         
    ARL16 for ontologies           About GeneDecksing


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    ARL16 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL16
    Interactions:

        Search GeneGlobe Interaction Network for ARL16

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARL16 (ENSP000003806354) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYTH2ENSP000004082364STRING: ENSP00000408236
    MON2ENSP000003772524STRING: ENSP00000377252
    COG6ENSP000003974414STRING: ENSP00000397441
    KIAA1432ENSP000004022404STRING: ENSP00000402240
    ARFGAP1ENSP000003146154STRING: ENSP00000314615
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ----
    GO:0007264small GTPase mediated signal transduction IEA--

    ARL16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL16



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARL16 gene: 
    NM_001040025.1  

    Unigene Cluster for ARL16:

    ADP-ribosylation factor-like 16
    Hs.658789  [show with all ESTs]
    Unigene Representative Sequence: AK095847
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000397498(uc002kbf.3) ENST00000577142 ENST00000573392 ENST00000571082
    ENST00000570910(uc021ufd.1) ENST00000574938 ENST00000570561 ENST00000576135
    ENST00000573569 ENST00000573715 ENST00000576914 ENST00000572704 ENST00000572937

    miRNA
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    Additional mRNA sequence: 

    AK095847.1 AK303526.1 AK304718.1 BC029633.1 BC042380.1 BC063687.1 BC105076.1 BC105078.1 

    14 DOTS entries:

    DT.100789944  DT.91753447  DT.120892481  DT.100789950  DT.95371284  DT.91753451  DT.100789946  DT.120892510 
    DT.65284873  DT.100789942  DT.100789943  DT.102838724  DT.91753453  DT.91753448 

    Selected AceView cDNA sequences (see all 126):

    CB119737 BG105464 BE746724 CR616295 BG029801 BX399419 AI363336 CF126971 
    BE272814 BM821150 AI361401 CR598237 AA419014 AA428991 BM761972 BX090742 
    BI092430 BG035440 CR615218 BM782864 CA335952 BM311411 BM923769 BU189027 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTGATCT
    ARL16 Expression
    About this image

    ARL16 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL16 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.658789
        Custom PCR Arrays for ARL16
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARL16 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl161 , 5 ADP-ribosylation factor-like 161, 5 84.71(n)1
    86.47(a)1
      11 (84.16 cM)5
    703171  NM_197995.21  NP_932112.21 
     1204648665 
    chicken
    (Gallus gallus)
    Aves ARL161 ADP-ribosylation factor-like 16 70.27(n)
    69.89(a)
      768991  XM_001232171.3  XP_001232172.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARL166
    ADP-ribosylation factor-like 16
    68(a)
    1 ↔ 1
    2(102382578-102386683)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.102452 Transcribed sequence with weak similarity to protein more 72.71(n)    137694351 
    zebrafish
    (Danio rerio)
    Actinopterygii arl161 ADP-ribosylation factor-like 16 59.13(n)
    60.71(a)
      100037345  NM_001089500.1  NP_001082969.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG136926
    --
    21(a)
    1 ↔ 1
    2L(421771-422489)


    ENSEMBL Gene Tree for ARL16 (if available)
    TreeFam Gene Tree for ARL16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL16 gene

    ARL16 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ARL16
    PGOHUM00000262415 PGOHUM00000262416


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL16 (see all 40)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs358762171,2
    C,F--79647743(+) TCAAGC/TGATTC 1 -- ds50012Minor allele frequency- T:0.25NA 4
    rs1913112651,2
    --79647797(+) CACCAC/TGCCCA 1 -- ds50010--------
    rs1505942911,2
    C--79647798(+) ACCACA/GCCCAG 1 -- ds50010--------
    rs73596091,2
    C,F--79647862(+) GTCTCG/AAACTC 1 -- ds50018Minor allele frequency- A:0.50NA WA CSA 14
    rs360004071,2
    C,F--79647875(+) GATCTC/GGTGAT 1 -- ds50017Minor allele frequency- G:0.42NA WA CSA 12
    rs1831248141,2
    --79647952(+) TGTTTC/TTAACT 1 -- ds50010--------
    rs1466916231,2
    --79647959(+) AACTCA/GAGGCC 1 -- ds50010--------
    rs1403134161,2
    C--79648004(+) ATGCCA/GTCTGT 1 -- ds50010--------
    rs760307371,2
    C,F--79648023(+) CAGGGT/ACAGGG 1 -- ds50011Minor allele frequency- A:0.04NA 120
    rs99078031,2
    C,F,H--79648035(+) ACCAGC/TGGCTC 1 -- ds500110Minor allele frequency- T:0.02NS EA NA WA 1212

    HapMap Linkage Disequilibrium report for ARL16 (79648204 - 79650954 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ARL16:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909116CNV Loss21882294
    dgv3330n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv828128CNV Loss20364138
    nsv909109CNV Loss21882294
    nsv909052CNV Loss21882294
    dgv3332n71CNV Loss21882294
    nsv470620CNV Loss18288195
    nsv428351CNV Gain18775914
    esv26223CNV Gain+Loss19812545

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL16 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with ARL16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    5. ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner. (PubMed id 21233210)1 Yang Y.K....Chen D.Y. (J. Biol. Chem. 2011)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339231 HGNC: 27902 AceView: LOC339231 Ensembl:ENSG00000214087 euGenes: HUgn339231
    ECgene: ARL16 H-InvDB: ARL16

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARL16 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARL16 gene:
    Search GeneIP for patents involving ARL16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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