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Aliases for ARL16 Gene

Aliases for ARL16 Gene

  • ADP Ribosylation Factor Like GTPase 16 2 3 5
  • ADP-Ribosylation Factor Like GTPase 16 2

External Ids for ARL16 Gene

Previous GeneCards Identifiers for ARL16 Gene

  • GC17M077259
  • GC17M079649
  • GC17M075094

Summaries for ARL16 Gene

GeneCards Summary for ARL16 Gene

ARL16 (ADP Ribosylation Factor Like GTPase 16) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL16 Gene

Genomics for ARL16 Gene

Regulatory Elements for ARL16 Gene

Enhancers for ARL16 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARL16 on UCSC Golden Path with GeneCards custom track

Promoters for ARL16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARL16 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL16 Gene

81,681,155 bp from pter
81,683,924 bp from pter
2,770 bases
Minus strand

Genomic View for ARL16 Gene

Genes around ARL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL16 Gene

Proteins for ARL16 Gene

  • Protein details for ARL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 16
    Protein Accession:

    Protein attributes for ARL16 Gene

    197 amino acids
    Molecular mass:
    20936 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL16 Gene

Proteomics data for ARL16 Gene at MOPED

Post-translational modifications for ARL16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARL16 Gene

Domains & Families for ARL16 Gene

Gene Families for ARL16 Gene

Protein Domains for ARL16 Gene

Suggested Antigen Peptide Sequences for ARL16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL16: view

Function for ARL16 Gene

Gene Ontology (GO) - Molecular Function for ARL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARL16: view
genes like me logo Genes that share phenotypes with ARL16: view

Animal Model Products

miRNA for ARL16 Gene

miRTarBase miRNAs that target ARL16

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL16 Gene

Localization for ARL16 Gene

Subcellular locations from

Jensen Localization Image for ARL16 Gene COMPARTMENTS Subcellular localization image for ARL16 gene
Compartment Confidence
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARL16 Gene

Pathways & Interactions for ARL16 Gene

SuperPathways for ARL16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL16 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARL16 Gene

Drugs & Compounds for ARL16 Gene

No Compound Related Data Available

Transcripts for ARL16 Gene

Unigene Clusters for ARL16 Gene

ADP-ribosylation factor-like 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARL16 Gene

No ASD Table

Relevant External Links for ARL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL16 Gene

mRNA expression in normal human tissues for ARL16 Gene

Protein differential expression in normal tissues from HIPED for ARL16 Gene

This gene is overexpressed in Plasma (59.1) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL16 Gene

SOURCE GeneReport for Unigene cluster for ARL16 Gene Hs.658789

genes like me logo Genes that share expression patterns with ARL16: view

Protein tissue co-expression partners for ARL16 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARL16 Gene

Orthologs for ARL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARL16 35
  • 86.55 (n)
  • 86.14 (a)
ARL16 36
  • 79 (a)
(Canis familiaris)
Mammalia ARL16 35
  • 85.08 (n)
  • 84.3 (a)
ARL16 36
  • 81 (a)
(Mus musculus)
Mammalia Arl16 35
  • 84.71 (n)
  • 86.47 (a)
Arl16 16
Arl16 36
  • 85 (a)
(Pan troglodytes)
Mammalia ARL16 35
  • 99.32 (n)
  • 99.49 (a)
ARL16 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Arl16 35
  • 83.33 (n)
  • 85.88 (a)
(Monodelphis domestica)
Mammalia ARL16 36
  • 83 (a)
(Gallus gallus)
Aves ARL16 35
  • 70.27 (n)
  • 69.89 (a)
ARL16 36
  • 62 (a)
(Anolis carolinensis)
Reptilia ARL16 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl16 35
  • 62.36 (n)
  • 59.18 (a)
Str.10245 35
(Danio rerio)
Actinopterygii arl16 35
  • 59.13 (n)
  • 60.71 (a)
arl16 36
  • 59 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13692 36
  • 21 (a)
Species with no ortholog for ARL16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL16 Gene

Gene Tree for ARL16 (if available)
Gene Tree for ARL16 (if available)

Paralogs for ARL16 Gene Pseudogenes for ARL16 Gene

genes like me logo Genes that share paralogs with ARL16: view

No data available for Paralogs for ARL16 Gene

Variants for ARL16 Gene

Sequence variations from dbSNP and Humsavar for ARL16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_059129 -
rs1134381 -- 81,681,336(-) TAATC(C/T)CAGCT utr-variant-3-prime
rs7359609 -- 81,680,832(+) GTCTC(A/G)AACTC downstream-variant-500B
rs8076090 -- 81,681,497(+) TGCCT(A/G)GCCCC utr-variant-3-prime
rs11548422 -- 81,681,231(-) GAGTG(A/T)AACTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARL16 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV Gain+Loss 19812545
nsv828128 CNV Loss 20364138
nsv909052 CNV Loss 21882294
nsv428351 CNV Gain 18775914
dgv3330n71 CNV Loss 21882294
dgv3332n71 CNV Loss 21882294
nsv470620 CNV Loss 18288195
nsv909109 CNV Loss 21882294
dgv3333n71 CNV Loss 21882294
nsv909116 CNV Loss 21882294

Variation tolerance for ARL16 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.44; 77.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARL16 Gene

Disorders for ARL16 Gene

Relevant External Links for ARL16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARL16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL16 Gene

Publications for ARL16 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner. (PMID: 21233210) Yang Y.K. … Chen D.Y. (J. Biol. Chem. 2011) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for ARL16 Gene

Sources for ARL16 Gene