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Aliases for ARL16 Gene

Aliases for ARL16 Gene

  • ADP Ribosylation Factor Like GTPase 16 2 3 5
  • ADP-Ribosylation Factor Like GTPase 16 2

External Ids for ARL16 Gene

Previous GeneCards Identifiers for ARL16 Gene

  • GC17M077259
  • GC17M079649
  • GC17M075094

Summaries for ARL16 Gene

Entrez Gene Summary for ARL16 Gene

  • The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). This protein has been shown to have an inhibitory role in the cellular antiviral response. This gene product interacts with the C-terminal domain of the DEXD/H-box helicase 58 (DDX58) gene product. This interaction was found to suppress the association between the DDX58 gene product and RNA, thereby negatively regulating the activity of the DDX58 gene product. [provided by RefSeq, Jul 2016]

GeneCards Summary for ARL16 Gene

ARL16 (ADP Ribosylation Factor Like GTPase 16) is a Protein Coding gene. GO annotations related to this gene include GTP binding.

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL16 Gene

Genomics for ARL16 Gene

Regulatory Elements for ARL16 Gene

Enhancers for ARL16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17G081709 1.4 ENCODE dbSUPER 66.5 -28.4 -28391 4.7 HNRNPUL1 PKNOX1 FOXA2 MLX CREB3L1 AGO1 ZFP64 ARID4B SIN3A FEZF1 ARL16 ENSG00000262877 TSPAN10 CCDC137 LOC105376790 LOC100130370 ENSG00000262049 RFNG GC17M081707 GC17P081724
GH17G081700 1.4 ENCODE dbSUPER 61.6 -18.9 -18867 4.2 HDGF MLX CREB3L1 AGO1 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ARL16 ENSG00000262049 TSPAN10 GCGR PPP1R27 MCRIP1 ENSG00000262652 CCDC137 NARF-IT1 ARL2BPP9
GH17G081664 1.1 ENCODE 76.1 +17.1 17087 3.7 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 ARL16 ENSG00000262049 CCDC137 HGS ENSG00000265678 OGFOD3 NARF-IT1 ARL2BPP9 ENSG00000262652 ENSG00000262877
GH17G081579 1.3 FANTOM5 ENCODE dbSUPER 40 +103.8 103820 1.6 ZNF263 ZIC2 ZNF2 GLIS2 ZSCAN16 POLR2A GLIS1 PRDM10 ZNF600 ZNF423 ARL16 NPLOC4 HGS PCYT2 ENSG00000207021 GC17M081598 PIR48383
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL16 on UCSC Golden Path with GeneCards custom track

Promoters for ARL16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000099462 24 1801 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 SLC30A9 ZNF143 FOS SP3

Genomic Location for ARL16 Gene

81,681,155 bp from pter
81,683,924 bp from pter
2,770 bases
Minus strand

Genomic View for ARL16 Gene

Genes around ARL16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL16 Gene

Proteins for ARL16 Gene

  • Protein details for ARL16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 16
    Protein Accession:

    Protein attributes for ARL16 Gene

    197 amino acids
    Molecular mass:
    20936 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL16 Gene

Post-translational modifications for ARL16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARL16 Gene

Domains & Families for ARL16 Gene

Gene Families for ARL16 Gene

Protein Domains for ARL16 Gene

Suggested Antigen Peptide Sequences for ARL16 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL16: view

Function for ARL16 Gene

Gene Ontology (GO) - Molecular Function for ARL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL16: view
genes like me logo Genes that share phenotypes with ARL16: view

Animal Model Products

CRISPR Products

miRNA for ARL16 Gene

miRTarBase miRNAs that target ARL16

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL16 Gene

Localization for ARL16 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL16 gene
Compartment Confidence
mitochondrion 2
cytosol 2
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARL16: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARL16 Gene

Pathways & Interactions for ARL16 Gene

SuperPathways for ARL16 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL16: view

No data available for Pathways by source and SIGNOR curated interactions for ARL16 Gene

Drugs & Compounds for ARL16 Gene

No Compound Related Data Available

Transcripts for ARL16 Gene

Unigene Clusters for ARL16 Gene

ADP-ribosylation factor-like 16:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL16 Gene

No ASD Table

Relevant External Links for ARL16 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL16 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL16 Gene

Protein differential expression in normal tissues from HIPED for ARL16 Gene

This gene is overexpressed in Plasma (59.1) and Peripheral blood mononuclear cells (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL16 Gene

Protein tissue co-expression partners for ARL16 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL16 Gene:


SOURCE GeneReport for Unigene cluster for ARL16 Gene:


Evidence on tissue expression from TISSUES for ARL16 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with ARL16: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL16 Gene

Orthologs for ARL16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL16 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL16 34 35
  • 99.32 (n)
(Bos Taurus)
Mammalia ARL16 34 35
  • 86.55 (n)
(Canis familiaris)
Mammalia ARL16 34 35
  • 85.08 (n)
(Mus musculus)
Mammalia Arl16 34 16 35
  • 84.71 (n)
(Rattus norvegicus)
Mammalia Arl16 34
  • 83.33 (n)
(Monodelphis domestica)
Mammalia ARL16 35
  • 83 (a)
(Gallus gallus)
Aves ARL16 34 35
  • 70.27 (n)
(Anolis carolinensis)
Reptilia ARL16 35
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl16 34
  • 62.36 (n)
Str.10245 34
(Danio rerio)
Actinopterygii arl16 34 35
  • 59.13 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13692 35
  • 21 (a)
Species where no ortholog for ARL16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL16 Gene

Gene Tree for ARL16 (if available)
Gene Tree for ARL16 (if available)

Paralogs for ARL16 Gene Pseudogenes for ARL16 Gene

genes like me logo Genes that share paralogs with ARL16: view

No data available for Paralogs for ARL16 Gene

Variants for ARL16 Gene

Sequence variations from dbSNP and Humsavar for ARL16 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs863223352 Likely pathogenic 81,683,794(-) GAGCC(G/T)CGGCG nc-transcript-variant, upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000298277 -- 81,681,733(+) TGGCC(G/T)GGAGC nc-transcript-variant, reference, missense
rs1000856090 -- 81,684,375(+) GGCCC(C/G)GGCAT intron-variant, upstream-variant-2KB
rs1000888873 -- 81,684,579(+) CCCAC(C/T)TTTTG intron-variant, upstream-variant-2KB
rs1002119525 -- 81,684,986(+) TATCC(A/G)GGAAA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ARL16 Gene

Variant ID Type Subtype PubMed ID
esv26223 CNV gain+loss 19812545
nsv428351 CNV gain 18775914
nsv470620 CNV loss 18288195
nsv828128 CNV loss 20364138
nsv952390 CNV deletion 24416366

Variation tolerance for ARL16 Gene

Residual Variation Intolerance Score: 36.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.44; 77.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL16 Gene

Disorders for ARL16 Gene

Relevant External Links for ARL16

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARL16 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL16 Gene

Publications for ARL16 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. ARF-like protein 16 (ARL16) inhibits RIG-I by binding with its C-terminal domain in a GTP-dependent manner. (PMID: 21233210) Yang Y.K. … Chen D.Y. (J. Biol. Chem. 2011) 3 64
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64

Products for ARL16 Gene

Sources for ARL16 Gene

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