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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL15 Gene

protein-coding   GIFtS: 49
GCID: GC05M053180

ADP-Ribosylation Factor-Like 15

(Previous name: ADP-ribosylation factor related protein 2)
(Previous symbol: ARFRP2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADP-Ribosylation Factor-Like 151 2
ARFRP21 2 3
ADP-Ribosylation Factor Related Protein 21 2
ADP-Ribosylation Factor-Related Protein 22 3
ARF-Related Protein 22 3
ADP-Ribosylation Factor-Like Protein 152

External Ids:    HGNC: 259451   Entrez Gene: 546222   Ensembl: ENSG000001853057   UniProtKB: Q9NXU53   

Export aliases for ARL15 gene to outside databases

Previous GC identifers: GC05M053217 GC05M050152


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARL15 Gene: 
ARL15 (ADP-ribosylation factor-like 15) is a protein-coding gene. Diseases associated with ARL15 include cholera, and obesity. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL15 gene promoter:
         FOXD3   POU3F2   GATA-1   POU2F1   FOXJ2 (long isoform)   POU2F1a   FOXJ2   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL15 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2   Ensembl cytogenetic band:  5q11.2   HGNC cytogenetic band: 5p15.2

ARL15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL15 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M053180:  view genomic region     (about GC identifiers)

Start:
53,179,775 bp from pter      End:
53,606,412 bp from pter
Size:
426,638 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARL15_HUMAN, Q9NXU5 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 15  
Size: 204 amino acids; 22876 Da
Secondary accessions: Q6IAD0

Explore the universe of human proteins at neXtProt for ARL15: NX_Q9NXU5

Explore proteomics data for ARL15 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NXU5

  • ARL15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARL15 Protein Expression
    REFSEQ proteins: NP_061960.1  
    ENSEMBL proteins: 
     ENSP00000473508   ENSP00000433427   ENSP00000432680  

    Human Recombinant Protein Products for ARL15: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARL15 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----

    ARL15 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARL: ADP-ribosylation factors-like

    3 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry Q9NXU5

    ProtoNet protein and cluster: Q9NXU5

    UniProtKB/Swiss-Prot: ARL15_HUMAN, Q9NXU5
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005525GTP binding IEA--
         
    ARL15 for ontologies           About GeneDecksing


    Animal Models:
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    miRNA
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    miRTarBase miRNAs that target ARL15:
    hsa-let-7b (MIRT005226)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARL15
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL15 (see all 29):
    hsa-miR-140-5p hsa-miR-30c hsa-miR-142-3p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-374a hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidARL15 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL15

    5/19 Interacting proteins for ARL15 (Q9NXU52, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    B4GALT3O605122, 3MINT-64611 I2D: score=5 
    CCDC90BQ9GZT62, 3MINT-64620 I2D: score=5 
    FUNDC2Q9BWH22, 3MINT-64621 I2D: score=5 
    GAPDHP044062, 3MINT-64612 I2D: score=5 
    GRIPAP1Q4V3282, 3MINT-64622 I2D: score=5 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ----
    GO:0007264small GTPase mediated signal transduction IEA--

    ARL15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARL15

    Search CenterWatch for drugs/clinical trials and news about ARL15

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARL15 gene: 
    NM_019087.2  

    Unigene Cluster for ARL15:

    ADP-ribosylation factor-like 15
    Hs.659125  [show with all ESTs]
    Unigene Representative Sequence: AK000058
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000502271(uc010ivs.1) ENST00000504924(uc003jpg.1) ENST00000510591
    ENST00000507646 ENST00000505630 ENST00000505383
    miRNA
    Products:
         
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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL15 (see all 29):
    hsa-miR-140-5p hsa-miR-30c hsa-miR-142-3p hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-3129-5p hsa-miR-374a hsa-miR-30d
    SwitchGear 3'UTR luciferase reporter plasmidARL15 3' UTR sequence
    Inhib. RNA
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    Sirion Biotech Customized lentivirus for stable overexpression of ARL15 
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL15

    Additional mRNA sequence: 

    AK000058.1 AK290886.1 AK311482.1 BC026093.1 CR457225.1 

    5 DOTS entries:

    DT.310174  DT.97837158  DT.120879133  DT.100019334  DT.97837159 

    24/34 AceView cDNA sequences (see all 34):

    AA495750 BQ952025 N31301 NM_019087 CB994377 AK000058 BM928338 BC026093 
    CR457225 AA604578 CD687130 BG532262 AL709896 AX772814 AI758190 AL702172 
    AI350192 BX094743 AA557396 BX281836 BF435889 BG496253 BG547596 BM927085 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GATTTGACAA
    ARL15 Expression
    About this image


    See ARL15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL15

    SOURCE GeneReport for Unigene cluster: Hs.659125
        SABiosciences Custom PCR Arrays for ARL15
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARL15 gene from 7/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl151 , 5 ADP-ribosylation factor-like 151, 5 90.36(n)1
    97.06(a)1
      13 (64.02 cM)5
    2186391  NM_172595.41  NP_766183.11 
     1137945055 
    chicken
    (Gallus gallus)
    Aves ARL151 ADP-ribosylation factor-like 15 86.07(n)
    93.12(a)
      769515  XM_001232797.1  XP_001232798.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL156
    Uncharacterized protein
    87(a)
    1 ↔ 1
    2(3019481-3026399)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.156542 Xenopus laevis transcribed sequence with moderate similarity more 79.3(n)    CF548201.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arl15b1 ADP-ribosylation factor-like 15b 73.12(n)
    83.77(a)
      560030  XM_001923512.2  XP_001923547.1 
    worm
    (Caenorhabditis elegans)
    Secernentea arl-136
    Protein ARL-13, isoform a
    11(a)
    1 ↔ 1
    I(2065727-2069049)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARF36
    Glucose-repressible ADP-ribosylation factor, GTPas...
    25(a)
    1 → many
    XV(502795-503346)


    ENSEMBL Gene Tree for ARL15 (if available)
    TreeFam Gene Tree for ARL15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL15 gene
    ARL22  ARL92  ARL32  ARL102  
    18 SIMAP similar genes for ARL15 using alignment to 2 protein entries:     ARL15_HUMAN (see all proteins):
    ARL8A    ARL8B    ARL3    ARF6    ARL2    ARL14
    ARL6    ARL11    TRIM23    ARF5    ARF1    ARF3
    ARF4    ARL4C    ARL5B    ARL4A    ARL13B    ARL4D

    ARL15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/8231 SNPs in ARL15 are shown (see all 8231)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs58679131,2
    C--50340866(+) CCTTT-/CCCCCCCC 1 -- int10--------
    rs2557621,2
    C--50340880(+) CCCCCC/GCAAAG 1 -- int10--------
    rs1408731301,2
    --53116899(+) TTCCTA/GTATAA 1 -- int10--------
    rs1148084681,2
    C,F--53180676(+) GGAATT/GGTGTA 1 -- ut311Minor allele frequency- G:0.02NA 120
    rs1923408281,2
    --53180692(+) TCATCG/TGAATA 1 -- ut310--------
    rs1497522481,2
    --53180768(+) GTATAC/TGAATC 1 -- ut310--------
    rs737571171,2
    C--53180769(+) TATACG/AAATCA 1 -- ut312Minor allele frequency- A:0.04WA 120
    rs1145128561,2
    C,F--53180801(+) TGACAT/CTAAAA 1 -- ut311Minor allele frequency- C:0.02WA 118
    rs77235101,2
    C,F--53180822(+) TAAAGA/CAGTGT 1 -- ut311Minor allele frequency- C:0.01WA 118
    rs1824017291,2
    --53180837(+) TGTTTC/TAAAGG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARL15 (53179775 - 53429775 bp, first 250kb of ARL15)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for ARL15 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2663755CNV Deletion23128226
    esv2542415CNV Deletion19546169
    esv2730185CNV Deletion23290073
    nsv329076CNV Insertion16902084
    nsv4829CNV Insertion18451855
    esv997418CNV Insertion20482838
    esv1766790CNV Insertion17803354
    nsv823074CNV Loss20364138
    nsv4830CNV Loss18451855
    esv7542CNV Loss19470904

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for ARL15:    About MalaCards
    cholera    obesity


    ARL15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARL15
    Human Genome Epidemiology (HuGE) Navigator: ARL15 (3 documents)

    Export disorders for ARL15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL15 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with ARL15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A genome-wide association study reveals variants in A RL15 that influence adiponectin levels. (PubMed id 20011104)1, 4, 9 Richards J.B....Spector T.D. (2009)
    2. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PubMed id 22479202)1, 4 Dastani Z....Kathiresan S. (2012)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Biological, clinical and population relevance of 95 l oci for blood lipids. (PubMed id 20686565)1, 4 Teslovich T.M....Kathiresan S. (2010)
    5. A genome-wide study reveals copy number variants excl usive to childhood obesity cases. (PubMed id 20950786)1, 4 Glessner J.T....Grant S.F. (2010)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    9. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    10. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 54622 HGNC: 25945 AceView: ARFRP2 Ensembl:ENSG00000185305 euGenes: HUgn54622
    ECgene: ARL15 H-InvDB: ARL15

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL15 gene:
    Search GeneIP for patents involving ARL15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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