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Aliases for ARL15 Gene

Aliases for ARL15 Gene

  • ADP Ribosylation Factor Like GTPase 15 2 3 5
  • ADP-Ribosylation Factor-Related Protein 2 3 4
  • ARF-Related Protein 2 3 4
  • ARFRP2 3 4
  • ADP-Ribosylation Factor Related Protein 2 2
  • ADP-Ribosylation Factor-Like Protein 15 3
  • ADP-Ribosylation Factor Like GTPase 15 2
  • ADP-Ribosylation Factor-Like 15 3

External Ids for ARL15 Gene

Previous HGNC Symbols for ARL15 Gene

  • ARFRP2

Previous GeneCards Identifiers for ARL15 Gene

  • GC05M053217
  • GC05M053180
  • GC05M050152

Summaries for ARL15 Gene

GeneCards Summary for ARL15 Gene

ARL15 (ADP Ribosylation Factor Like GTPase 15) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL8A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL15 Gene

Genomics for ARL15 Gene

Regulatory Elements for ARL15 Gene

Enhancers for ARL15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F054273 0.4 ENCODE 19.2 +36.7 36655 1.0 LEF1 ATF1 ZNF146 CBX3 ARNT TBL1XR1 ZNF316 NCOR1 GATA2 NFE2 ARL15 ENSG00000279638 GC05M054128
GH05F054248 0.2 Ensembl 17.5 +61.0 60986 1.6 PKNOX1 JUNB ZNF501 ZBTB40 IKZF1 EED NBN NR2F6 PRDM1 TRIM28 ARL15 HSPB3 ENSG00000279638 GC05M054128
GH05F054251 0.2 ENCODE 16.6 +58.3 58262 1.9 JUND FOS FOSL2 PRDM1 TCF7L2 ARL15 ENSG00000279638 GC05M054128
GH05F054289 0.7 FANTOM5 Ensembl 12 +20.5 20524 0.5 SMARCA4 POLR2A ZBTB33 ARL15 ENSG00000279638
GH05F054222 0.4 ENCODE 11.5 +89.2 89153 0.7 ZNF316 EMSY MAFK ARL15 FST GC05M054128 ENSG00000279638
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARL15 on UCSC Golden Path with GeneCards custom track

Promoters for ARL15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001280071 186 4001 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZNF143

Genomic Location for ARL15 Gene

Chromosome:
5
Start:
53,883,945 bp from pter
End:
54,310,586 bp from pter
Size:
426,642 bases
Orientation:
Minus strand

Genomic View for ARL15 Gene

Genes around ARL15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL15 Gene

Proteins for ARL15 Gene

  • Protein details for ARL15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXU5-ARL15_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 15
    Protein Accession:
    Q9NXU5
    Secondary Accessions:
    • Q6IAD0

    Protein attributes for ARL15 Gene

    Size:
    204 amino acids
    Molecular mass:
    22876 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL15 Gene

Post-translational modifications for ARL15 Gene

  • Ubiquitination at Lys 157
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL15 Gene

No data available for DME Specific Peptides for ARL15 Gene

Domains & Families for ARL15 Gene

Gene Families for ARL15 Gene

Protein Domains for ARL15 Gene

Suggested Antigen Peptide Sequences for ARL15 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXU5

UniProtKB/Swiss-Prot:

ARL15_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL15: view

Function for ARL15 Gene

Gene Ontology (GO) - Molecular Function for ARL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL15: view

Phenotypes for ARL15 Gene

genes like me logo Genes that share phenotypes with ARL15: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL15 Gene

Localization for ARL15 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL15 Gene COMPARTMENTS Subcellular localization image for ARL15 gene
Compartment Confidence
extracellular 5
cytosol 3
nucleus 2
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with ARL15: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARL15 Gene

Pathways & Interactions for ARL15 Gene

SuperPathways for ARL15 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with ARL15: view

No data available for Pathways by source and SIGNOR curated interactions for ARL15 Gene

Transcripts for ARL15 Gene

Unigene Clusters for ARL15 Gene

ADP-ribosylation factor-like 15:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL15 Gene

No ASD Table

Relevant External Links for ARL15 Gene

GeneLoc Exon Structure for
ARL15
ECgene alternative splicing isoforms for
ARL15

Expression for ARL15 Gene

mRNA expression in normal human tissues for ARL15 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARL15 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARL15 Gene:

ARL15

SOURCE GeneReport for Unigene cluster for ARL15 Gene:

Hs.659125
genes like me logo Genes that share expression patterns with ARL15: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ARL15 Gene

Orthologs for ARL15 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL15 34 35
  • 99.51 (n)
dog
(Canis familiaris)
Mammalia ARL15 34 35
  • 95.26 (n)
cow
(Bos Taurus)
Mammalia ARL15 34 35
  • 93.73 (n)
mouse
(Mus musculus)
Mammalia Arl15 34 16 35
  • 90.36 (n)
rat
(Rattus norvegicus)
Mammalia Arl15 34
  • 88.83 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARL15 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL15 35
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARL15 34 35
  • 85.79 (n)
lizard
(Anolis carolinensis)
Reptilia ARL15 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl15 34
  • 79.51 (n)
Str.3925 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15654 34
zebrafish
(Danio rerio)
Actinopterygii arl15b 34 35
  • 73.12 (n)
arl15a 35
  • 67 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3759 34
worm
(Caenorhabditis elegans)
Secernentea arl-13 35
  • 13 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARL1 35
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3634 35
  • 13 (a)
ManyToMany
Species where no ortholog for ARL15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL15 Gene

ENSEMBL:
Gene Tree for ARL15 (if available)
TreeFam:
Gene Tree for ARL15 (if available)

Paralogs for ARL15 Gene

Paralogs for ARL15 Gene

(18) SIMAP similar genes for ARL15 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARL15: view

Variants for ARL15 Gene

Sequence variations from dbSNP and Humsavar for ARL15 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10036830 -- 54,057,297(+) CAGAG(C/G)TGAAG intron-variant
rs10036972 -- 54,052,626(+) tagaa(C/T)gatcc intron-variant
rs10037344 -- 54,063,060(+) TCATT(C/T)TACAT intron-variant
rs10038225 -- 54,058,667(+) agaag(C/G)gggac intron-variant
rs10038268 -- 54,297,427(+) GGAGT(A/T)TGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL15 Gene

Variant ID Type Subtype PubMed ID
dgv5666n100 CNV gain 25217958
dgv5668n100 CNV gain 25217958
dgv9786n54 CNV gain 21841781
esv1766790 CNV insertion 17803354
esv2542415 CNV deletion 19546169
esv2663755 CNV deletion 23128226
esv2730185 CNV deletion 23290073
esv3570146 CNV loss 25503493
esv3605079 CNV loss 21293372
esv3605080 CNV loss 21293372
esv3605081 CNV gain 21293372
esv3605082 CNV loss 21293372
esv3605083 CNV loss 21293372
esv7542 CNV loss 19470904
esv997418 CNV insertion 20482838
nsv1024281 CNV gain 25217958
nsv328114 CNV deletion 16902084
nsv329076 CNV insertion 16902084
nsv329660 CNV deletion 16902084
nsv472823 CNV novel sequence insertion 20440878
nsv476695 CNV novel sequence insertion 20440878
nsv4829 CNV insertion 18451855
nsv4830 CNV deletion 18451855
nsv524694 CNV gain 19592680
nsv598175 CNV gain 21841781
nsv598178 CNV loss 21841781
nsv823074 CNV loss 20364138
nsv830298 CNV gain 17160897
nsv830299 CNV gain 17160897

Variation tolerance for ARL15 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.23; 5.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL15 Gene

Disorders for ARL15 Gene

Relevant External Links for ARL15

Genetic Association Database (GAD)
ARL15
Human Genome Epidemiology (HuGE) Navigator
ARL15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL15

No disorders were found for ARL15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL15 Gene

Publications for ARL15 Gene

  1. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. (PMID: 20011104) Richards J.B. … Spector T.D. (PLoS Genet. 2009) 3 22 46 64
  2. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. (PMID: 22479202) Dastani Z. … Kathiresan S. (PLoS Genet. 2012) 3 46 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  4. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich T.M. … Kathiresan S. (Nature 2010) 3 46 64
  5. A genome-wide study reveals copy number variants exclusive to childhood obesity cases. (PMID: 20950786) Glessner J.T. … Grant S.F. (Am. J. Hum. Genet. 2010) 3 46 64

Products for ARL15 Gene

Sources for ARL15 Gene

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