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ARL14EPL Gene

protein-coding   GIFtS: 18
GCID: GC05P115388

ADP-Ribosylation Factor-Like 14 Effector Protein-Like

  Search for ARL14EPL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 14 Effector Protein-Like1 2
ARL14 Effector Protein-Like2

External Ids:    HGNC: 442011   Entrez Gene: 6441002   Ensembl: ENSG000002682237   UniProtKB: P0DKL93   

Export aliases for ARL14EPL gene to outside databases

Previous GC identifer: GC05U901645


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARL14EPL Gene:
ARL14EPL (ADP-ribosylation factor-like 14 effector protein-like) is a protein-coding gene. An important paralog of this gene is ARL14EP.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for ARL14EPL
         Other transcription factors

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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL14EPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   HGNC cytogenetic band: 5q23.1

ARL14EPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL14EPL gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P115388:  view genomic region     (about GC identifiers)

Start:
115,387,163 bp from pter      End:
115,395,815 bp from pter
Size:
8,653 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: A14EL_HUMAN, P0DKL9 (See protein sequence)
Recommended Name: ARL14 effector protein-like  
Size: 152 amino acids; 17712 Da

Explore the universe of human proteins at neXtProt for ARL14EPL: NX_P0DKL9

REFSEQ proteins: NP_001182510.1  
ENSEMBL proteins: 
 ENSP00000472409  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: P0DKL9


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL14EPL
Interactions:

    Search GeneGlobe Interaction Network for ARL14EPL

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for ARL14EPL (A14EL)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ARL14EPL gene: 
NM_001195581.1  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000601302
miRNA
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

ARL14EPL Protein expression data from MOPED1, PaxDb2 and MaxQB3 --
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for ARL14EPL gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Arl14epl1 , 5 predicted gene 9495
ADP-ribosylation factor-like 14 effector protein-like1
84.21(n)1
88.16(a)1
  18 (24.88 cM)5
3811421  NM_001033446.21  NP_001028618.11 
 469259825 
chicken
(Gallus gallus)
Aves ARL14EPL1 ADP-ribosylation factor-like 14 effector protein-like 65.53(n)
58.5(a)
  100858213  XM_003643095.2  XP_003643143.2 
tropical clawed frog
(Xenopus tropicalis)
Amphibia arl14epl1 ADP-ribosylation factor-like 14 effector protein-like 68.23(n)
65.77(a)
  100495946  XM_004910488.1  XP_004910545.1 
fruit fly
(Drosophila melanogaster)
Insecta CG144646
--
26(a)
1 → many
2R(716725-717440)


ENSEMBL Gene Tree for ARL14EPL (if available)
TreeFam Gene Tree for ARL14EPL (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ARL14EPL gene
ARL14EP2  ENSG000002687142  
1 SIMAP similar gene for ARL14EPL using alignment to 1 protein entry:     A14EL_HUMAN:
ARL14EP

Find genes that share paralogs with ARL14EPL           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ARL14EPL (see all 335)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 5 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1139989241,2
C,F--115385213(+) ATCAGG/TAAGTA 1 -- us2k11Minor allele frequency- T:0.05WA 118
rs1404313991,2
C--115385253(+) GCATGA/TTACTG 1 -- us2k10--------
rs782879521,2
C--115385407(+) TTTGAA/GGGACC 1 -- us2k12Minor allele frequency- G:0.14CSA EA 122
rs100602761,2
C,F,H--115385416(+) CCATAA/GAAGAG 1 -- us2k123Minor allele frequency- G:0.21NS EA NA WA CSA 2472
rs25607081,2
C,F,O,A,H--115385500(-) CAGTGG/ACACTG 1 -- us2k124Minor allele frequency- A:0.23NS EA NA WA CSA 2175
rs788853751,2
F--115385526(+) AATAAC/TAGTTA 1 -- us2k11Minor allele frequency- T:0.20WA 118
rs25607071,2
C,F,A,H--115385535(-) AATTTG/ATAATA 1 -- us2k111Minor allele frequency- A:0.29NA WA CSA EA 372
rs25607061,2
C,F,O,A,H--115385561(-) AAATAT/CTTGGG 1 -- us2k125Minor allele frequency- C:0.44NA NS EA WA 2464
rs1504119641,2
C--115385633(+) CAGCAA/GATGCA 1 -- us2k10--------
rs25607051,2
C,F,H--115385683(-) TAAAGC/GCTCAG 1 -- us2k131Minor allele frequency- G:0.24NS EA NA WA CSA 2786

HapMap Linkage Disequilibrium report for ARL14EPL (115387163 - 115395815 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for ARL14EPL: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing ARL14EPL
DNA2.0 Custom Variant and Variant Library Synthesis for ARL14EPL

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ARL14EPL gene integrated from 10 sources:
(articles sorted by number of sources associating them with ARL14EPL)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (Nature 2004)
  2. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (Proc. Natl. Acad. Sci. U.S.A. 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 644100 HGNC: 44201 Ensembl:ENSG00000268223 euGenes: HUgn644100 ECgene: ARL14EPL
H-InvDB: ARL14EPL

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ARL14EPL Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ARL14EPL gene:
Search GeneIP for patents involving ARL14EPL

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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