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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL14EPL Gene

protein-coding   GIFtS: 24
GCID: GC05P115388

ADP-Ribosylation Factor-Like 14 Effector Protein-Like

  Search for ARL14EPL
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADP-Ribosylation Factor-Like 14 Effector Protein-Like1 2
ARL14 Effector Protein-Like2

External Ids:    HGNC: 442011   Entrez Gene: 6441002   Ensembl: ENSG000002682237   UniProtKB: P0DKL93   

Export aliases for ARL14EPL gene to outside databases

Previous GC identifer: GC05U901645


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARL14EPL Gene: 
ARL14EPL (ADP-ribosylation factor-like 14 effector protein-like) is a protein-coding gene. An important paralog of this gene is ARL14EP.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.2  NT_034772.6  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ARL14EPL
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ARL14EPL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL14EPL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q23.1   Ensembl cytogenetic band:  5q23.1   HGNC cytogenetic band: 5q23.1

ARL14EPL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL14EPL gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P115388:  view genomic region     (about GC identifiers)

Start:
115,387,163 bp from pter      End:
115,395,815 bp from pter
Size:
8,653 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: A14EL_HUMAN, P0DKL9 (See protein sequence)
Recommended Name: ARL14 effector protein-like  
Size: 152 amino acids; 17712 Da

Explore the universe of human proteins at neXtProt for ARL14EPL: NX_P0DKL9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P0DKL9

  • ARL14EPL Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001182510.1  
    ENSEMBL proteins: 
     ENSP00000472409  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026515 ARF7EP

    Graphical View of Domain Structure for InterPro Entry P0DKL9

    ProtoNet protein and cluster: P0DKL9


    ARL14EPL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL14EPL

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARL14EPL (A14EL)

    Search CenterWatch for drugs/clinical trials and news about ARL14EPL / A14EL

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARL14EPL gene: 
    NM_001195581.1  

    Unigene Cluster for ARL14EPL:

    ADP-ribosylation factor-like 14 effector protein-like
    Hs.730043  [show with all ESTs]
    Unigene Representative Sequence: NM_001195581
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000601302
    miRNA
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    2 DOTS entries:

    DT.120817019  DT.91995496 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    SOURCE GeneReport for Unigene cluster: Hs.730043
        SABiosciences Custom PCR Arrays for ARL14EPL
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARL14EPL gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl14epl1 , 5 predicted gene 9495
    ADP-ribosylation factor-like 14 effector protein-like1
    84.21(n)1
    88.16(a)1
      18 (24.88 cM)5
    3811421  NM_001033446.21  NP_001028618.11 
     469259825 
    chicken
    (Gallus gallus)
    Aves LOC1008582131 uncharacterized LOC100858213 72.32(n)
    69.49(a)
      100858213  XM_003643095.1  XP_003643143.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG144646
    --
    28(a)
    1 → many
    2R(716725-717440)


    ENSEMBL Gene Tree for ARL14EPL (if available)
    TreeFam Gene Tree for ARL14EPL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL14EPL gene
    ARL14EP2  ENSG000002687142  
    1 SIMAP similar gene for ARL14EPL using alignment to 1 protein entry:     A14EL_HUMAN:
    ARL14EP

    ARL14EPL for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/335 SNPs in ARL14EPL are shown (see all 335)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1139989241,2
    C,F--115385213(+) ATCAGG/TAAGTA 1 -- us2k11Minor allele frequency- T:0.05WA 118
    rs1404313991,2
    C--115385253(+) GCATGA/TTACTG 1 -- us2k10--------
    rs782879521,2
    C--115385407(+) TTTGAA/GGGACC 1 -- us2k12Minor allele frequency- G:0.14CSA EA 122
    rs100602761,2
    C,F,H--115385416(+) CCATAA/GAAGAG 1 -- us2k123Minor allele frequency- G:0.21NS EA NA WA CSA 2472
    rs25607081,2
    C,F,O,A,H--115385500(-) CAGTGG/ACACTG 1 -- us2k124Minor allele frequency- A:0.23NS EA NA WA CSA 2175
    rs788853751,2
    F--115385526(+) AATAAC/TAGTTA 1 -- us2k11Minor allele frequency- T:0.20WA 118
    rs25607071,2
    C,F,A,H--115385535(-) AATTTG/ATAATA 1 -- us2k111Minor allele frequency- A:0.29NA WA CSA EA 372
    rs25607061,2
    C,F,O,A,H--115385561(-) AAATAT/CTTGGG 1 -- us2k125Minor allele frequency- C:0.44NA NS EA WA 2464
    rs1504119641,2
    C--115385633(+) CAGCAA/GATGCA 1 -- us2k10--------
    rs25607051,2
    C,F,H--115385683(-) TAAAGC/GCTCAG 1 -- us2k131Minor allele frequency- G:0.24NS EA NA WA CSA 2786

    HapMap Linkage Disequilibrium report for ARL14EPL (115387163 - 115395815 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARL14EPL: --
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing ARL14EPL
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL14EPL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL14EPL gene integrated from 9 sources:
    (articles sorted by number of sources associating them with ARL14EPL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)2 Schmutz J.... Rubin E.M. (2004)
    2. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 644100 HGNC: 44201 Ensembl:ENSG00000268223 euGenes: HUgn644100 ECgene: ARL14EPL
    H-InvDB: ARL14EPL

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL14EPL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL14EPL gene:
    Search GeneIP for patents involving ARL14EPL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    transforming growth factor, beta 1
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