Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARL14EPL Gene

Aliases for ARL14EPL Gene

  • ADP Ribosylation Factor Like GTPase 14 Effector Protein Like 2 3 5
  • ADP-Ribosylation Factor Like GTPase 14 Effector Protein Like 2

External Ids for ARL14EPL Gene

Previous GeneCards Identifiers for ARL14EPL Gene

  • GC05U901645
  • GC05P115388

Summaries for ARL14EPL Gene

GeneCards Summary for ARL14EPL Gene

ARL14EPL (ADP Ribosylation Factor Like GTPase 14 Effector Protein Like) is a Protein Coding gene. An important paralog of this gene is ARL14EP.

Additional gene information for ARL14EPL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL14EPL Gene

Genomics for ARL14EPL Gene

Regulatory Elements for ARL14EPL Gene

Enhancers for ARL14EPL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H116032 1.1 Ensembl ENCODE 0.7 0.0 -17 0 ATF1 RAD21 RARA RFX5 SCRT2 FOS ATF7 CREM ZNF654 CEBPB ARL14EPL DDX43P1
GH05H116038 0.7 FANTOM5 ENCODE 0.4 +6.8 6793 0 POLR2A EBF1 SPI1 ARL14EPL GC05M116052
GH05H115977 0.9 ENCODE dbSUPER 0.2 -53.4 -53403 3 ZNF316 PRDM6 JUN MAFG FOS NFE2 EMSY MAFK LVRN DDX43P1 ARL14EPL
GH05H115990 0.4 dbSUPER 0.3 -39.8 -39848 4 RNF2 LVRN AP3S1 ATG12 RNU2-49P ENSG00000251118 DDX43P1 ARL14EPL
GH05H115987 0.4 dbSUPER 0.3 -43.5 -43511 3 POLR2A LVRN AP3S1 DDX43P1 ARL14EPL
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL14EPL on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL14EPL Gene

Chromosome:
5
Start:
116,032,324 bp from pter
End:
116,060,118 bp from pter
Size:
27,795 bases
Orientation:
Plus strand

Genomic View for ARL14EPL Gene

Genes around ARL14EPL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL14EPL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL14EPL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL14EPL Gene

Proteins for ARL14EPL Gene

  • Protein details for ARL14EPL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DKL9-A14EL_HUMAN
    Recommended name:
    ARL14 effector protein-like
    Protein Accession:
    P0DKL9

    Protein attributes for ARL14EPL Gene

    Size:
    152 amino acids
    Molecular mass:
    17712 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL14EPL Gene

Post-translational modifications for ARL14EPL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL14EPL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL14EPL Gene

Domains & Families for ARL14EPL Gene

Gene Families for ARL14EPL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for ARL14EPL Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARL14EPL: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ARL14EPL Gene

Function for ARL14EPL Gene

Phenotypes for ARL14EPL Gene

GenomeRNAi human phenotypes for ARL14EPL:
genes like me logo Genes that share phenotypes with ARL14EPL: view

Animal Model Products

CRISPR Products

miRNA for ARL14EPL Gene

miRTarBase miRNAs that target ARL14EPL

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL14EPL Gene

Localization for ARL14EPL Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for ARL14EPL Gene

Pathways & Interactions for ARL14EPL Gene

SuperPathways for ARL14EPL Gene

No Data Available

Interacting Proteins for ARL14EPL Gene

Gene Ontology (GO) - Biological Process for ARL14EPL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARL14EPL Gene

Drugs & Compounds for ARL14EPL Gene

No Compound Related Data Available

Transcripts for ARL14EPL Gene

mRNA/cDNA for ARL14EPL Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL14EPL Gene

ADP-ribosylation factor-like 14 effector protein-like:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL14EPL Gene

No ASD Table

Relevant External Links for ARL14EPL Gene

GeneLoc Exon Structure for
ARL14EPL
ECgene alternative splicing isoforms for
ARL14EPL

Expression for ARL14EPL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL14EPL Gene

NURSA nuclear receptor signaling pathways regulating expression of ARL14EPL Gene:

ARL14EPL

SOURCE GeneReport for Unigene cluster for ARL14EPL Gene:

Hs.730043
genes like me logo Genes that share expression patterns with ARL14EPL: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL14EPL Gene

Orthologs for ARL14EPL Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL14EPL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL14EPL 33
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia ARL14EPL 33
  • 87.5 (n)
-- 34
  • 86 (a)
OneToMany
cow
(Bos Taurus)
Mammalia ARL14EPL 33
  • 85.43 (n)
C10H11ORF46 34
  • 83 (a)
ManyToMany
-- 34
  • 60 (a)
ManyToMany
MGC134232 34
  • 60 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Arl14epl 33 16 34
  • 84.21 (n)
rat
(Rattus norvegicus)
Mammalia Arl14epl 33
  • 82.68 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 77 (a)
ManyToMany
-- 34
  • 63 (a)
ManyToMany
-- 34
  • 35 (a)
ManyToMany
-- 34
  • 16 (a)
ManyToMany
-- 34
  • 6 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 52 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARL14EPL 33
  • 65.53 (n)
-- 34
  • 53 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia arl14epl 33
  • 68.23 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14464 34
  • 26 (a)
OneToMany
Species where no ortholog for ARL14EPL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARL14EPL Gene

ENSEMBL:
Gene Tree for ARL14EPL (if available)
TreeFam:
Gene Tree for ARL14EPL (if available)

Paralogs for ARL14EPL Gene

Paralogs for ARL14EPL Gene

(1) SIMAP similar genes for ARL14EPL Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL14EPL: view

Variants for ARL14EPL Gene

Sequence variations from dbSNP and Humsavar for ARL14EPL Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000241779 -- 116,056,061(+) ATTTC(A/G)GTTGG intron-variant
rs1000310513 -- 116,052,210(+) CCCCC(A/G)GATTT intron-variant
rs1000957756 -- 116,057,823(+) GGAGT(A/C)TTATA intron-variant
rs1001179323 -- 116,059,890(+) GGACA(A/G)GGCTC utr-variant-3-prime
rs1001286946 -- 116,055,652(+) ATATA(A/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARL14EPL Gene

Variant ID Type Subtype PubMed ID
dgv10028n54 CNV gain 21841781
dgv5789n100 CNV gain 25217958
dgv5790n100 CNV loss 25217958
esv2763487 CNV gain 21179565
esv34146 CNV loss 18971310
nsv515611 CNV gain+loss 19592680
nsv527320 CNV loss 19592680
nsv968236 CNV duplication 23825009

Variation tolerance for ARL14EPL Gene

Gene Damage Index Score: 1.18; 23.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL14EPL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL14EPL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL14EPL Gene

Disorders for ARL14EPL Gene

Relevant External Links for ARL14EPL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL14EPL

No disorders were found for ARL14EPL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL14EPL Gene

Publications for ARL14EPL Gene

  1. The DNA sequence and comparative analysis of human chromosome 5. (PMID: 15372022) Schmutz J … Rubin EM (Nature 2004) 4 60
  2. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PMID: 10737800) Dias Neto E … Simpson AJ (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 60

Products for ARL14EPL Gene

Sources for ARL14EPL Gene

Content
Loading form....