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Aliases for ARL14EP Gene

Aliases for ARL14EP Gene

  • ADP-Ribosylation Factor-Like 14 Effector Protein 2 3
  • C11orf46 3 4 6
  • ARF7 Effector Protein 3 4
  • ARF7EP 3 4
  • Chromosome 11 Open Reading Frame 46 2
  • ARL14 Effector Protein 3
  • DJ299F11.1 3

External Ids for ARL14EP Gene

Previous HGNC Symbols for ARL14EP Gene

  • C11orf46

Previous GeneCards Identifiers for ARL14EP Gene

  • GC11P030344

Summaries for ARL14EP Gene

Entrez Gene Summary for ARL14EP Gene

  • The protein encoded by this gene is an effector protein. It interacts with ADP-ribosylation factor-like 14 [ARL14, also known as ADP-ribosylation factor 7 (ARF7)], beta-actin (ACTB) and actin-based motor protein myosin 1E (MYO1E). ARL14 is a small GTPase; it controls the export of major histocompatibility class II molecules by connecting to the actin network via this effector protein. [provided by RefSeq, Sep 2014]

GeneCards Summary for ARL14EP Gene

ARL14EP (ADP-Ribosylation Factor-Like 14 Effector Protein) is a Protein Coding gene. An important paralog of this gene is ARL14EPL.

UniProtKB/Swiss-Prot for ARL14EP Gene

  • Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL14EP Gene

Genomics for ARL14EP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARL14EP Gene

30,323,051 bp from pter
30,338,227 bp from pter
15,177 bases
Plus strand

Genomic View for ARL14EP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL14EP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL14EP Gene

No data available for Regulatory Elements for ARL14EP Gene

Proteins for ARL14EP Gene

  • Protein details for ARL14EP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ARL14 effector protein
    Protein Accession:
    Secondary Accessions:
    • Q5HYH9

    Protein attributes for ARL14EP Gene

    260 amino acids
    Molecular mass:
    29338 Da
    Quaternary structure:
    • Interacts with ARL14 and MYO1E.

neXtProt entry for ARL14EP Gene

Proteomics data for ARL14EP Gene at MOPED

Post-translational modifications for ARL14EP Gene

  • Ubiquitination at Lys104, Lys118, and Lys257
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL14EP Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL14EP Gene

Domains for ARL14EP Gene

Protein Domains for ARL14EP Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARL14EP: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ARL14EP Gene

Function for ARL14EP Gene

Molecular function for ARL14EP Gene

UniProtKB/Swiss-Prot Function: Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.

Gene Ontology (GO) - Molecular Function for ARL14EP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21458045
genes like me logo Genes that share ontologies with ARL14EP: view

Animal Model Products

CRISPR Products

miRNA for ARL14EP Gene

miRTarBase miRNAs that target ARL14EP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL14EP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARL14EP Gene

Localization for ARL14EP Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL14EP Gene


Gene Ontology (GO) - Cellular Components for ARL14EP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARL14EP: view

No data available for Subcellular locations from COMPARTMENTS for ARL14EP Gene

Pathways for ARL14EP Gene

SuperPathways for ARL14EP Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL14EP Gene


No data available for Pathways by source for ARL14EP Gene

Transcripts for ARL14EP Gene

mRNA/cDNA for ARL14EP Gene

Unigene Clusters for ARL14EP Gene

ADP-ribosylation factor-like 14 effector protein:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL14EP

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARL14EP
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL14EP Gene

No ASD Table

Relevant External Links for ARL14EP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL14EP Gene

mRNA expression in normal human tissues for ARL14EP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL14EP Gene

SOURCE GeneReport for Unigene cluster for ARL14EP Gene Hs.502208

mRNA Expression by UniProt/SwissProt for ARL14EP Gene

Tissue specificity: Expressed in the immune system.
genes like me logo Genes that share expressions with ARL14EP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARL14EP Gene

Orthologs for ARL14EP Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL14EP Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL14EP 35
  • 99.62 (n)
  • 99.62 (a)
ARL14EP 36
  • 100 (a)
(Bos Taurus)
Mammalia ARL14EP 35
  • 93.59 (n)
  • 97.31 (a)
ARL14EP 36
  • 98 (a)
(Canis familiaris)
Mammalia ARL14EP 35
  • 94.34 (n)
  • 97.68 (a)
ARL14EP 36
  • 98 (a)
(Mus musculus)
Mammalia Arl14ep 35
  • 87.39 (n)
  • 93.05 (a)
Arl14ep 16
Arl14ep 36
  • 87 (a)
(Monodelphis domestica)
Mammalia ARL14EP 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia ARL14EP 36
  • 89 (a)
(Rattus norvegicus)
Mammalia Arl14ep 35
  • 87 (n)
  • 93.44 (a)
(Gallus gallus)
Aves ARL14EP 36
  • 79 (a)
C5H11ORF46 35
  • 79.79 (n)
  • 83.78 (a)
(Anolis carolinensis)
Reptilia ARL14EP 36
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl14ep 35
  • 65.59 (n)
  • 69.35 (a)
Str.6132 35
(Danio rerio)
Actinopterygii arl14ep 36
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14464 36
  • 30 (a)
Species with no ortholog for ARL14EP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL14EP Gene

Gene Tree for ARL14EP (if available)
Gene Tree for ARL14EP (if available)

Paralogs for ARL14EP Gene

Paralogs for ARL14EP Gene

Selected SIMAP similar genes for ARL14EP Gene using alignment to 2 proteins: Pseudogenes for ARL14EP Gene

genes like me logo Genes that share paralogs with ARL14EP: view

Variants for ARL14EP Gene

Sequence variations from dbSNP and Humsavar for ARL14EP Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1063960 -- 30,338,011(+) ATTGA(A/T)TATTA downstream-variant-500B
rs1222205 -- 30,334,510(+) cgccc(A/G)gccaa intron-variant
rs1222206 -- 30,336,928(+) TCATC(A/T)TGGGT utr-variant-3-prime, downstream-variant-500B
rs1222214 -- 30,326,148(-) TTATA(C/G)AAGAT intron-variant
rs1222215 -- 30,326,049(-) AATTC(A/G)ATACA intron-variant

Relevant External Links for ARL14EP Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARL14EP Gene

Disorders for ARL14EP Gene

No disorders were found for ARL14EP Gene.

No data available for UniProtKB/Swiss-Prot for ARL14EP Gene

Publications for ARL14EP Gene

  1. A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. (PMID: 21458045) Paul P. … Neefjes J. (Cell 2011) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for ARL14EP Gene

Sources for ARL14EP Gene

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