Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARL14 Gene

Aliases for ARL14 Gene

  • ADP-Ribosylation Factor-Like 14 2 3
  • ADP-Ribosylation Factor 7 2 3 4
  • ARF7 3 4 6
  • ADP-Ribosylation Factor-Like Protein 14 3

External Ids for ARL14 Gene

Previous HGNC Symbols for ARL14 Gene

  • ARF7

Previous GeneCards Identifiers for ARL14 Gene

  • GC03P161881
  • GC03P160394
  • GC03P157793

Summaries for ARL14 Gene

GeneCards Summary for ARL14 Gene

ARL14 (ADP-Ribosylation Factor-Like 14) is a Protein Coding gene. Diseases associated with ARL14 include primary biliary cirrhosis. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL11.

UniProtKB/Swiss-Prot for ARL14 Gene

  • GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL14 Gene

Genomics for ARL14 Gene

Regulatory Elements for ARL14 Gene

Genomic Location for ARL14 Gene

Start:
160,677,159 bp from pter
End:
160,678,452 bp from pter
Size:
1,294 bases
Orientation:
Plus strand

Genomic View for ARL14 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL14 Gene

Proteins for ARL14 Gene

  • Protein details for ARL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4G2-ARL14_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 14
    Protein Accession:
    Q8N4G2
    Secondary Accessions:
    • Q9H655

    Protein attributes for ARL14 Gene

    Size:
    192 amino acids
    Molecular mass:
    21588 Da
    Quaternary structure:
    • Interacts with ARL14EP.

neXtProt entry for ARL14 Gene

Proteomics data for ARL14 Gene at MOPED

Post-translational modifications for ARL14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL14 Gene

Domains for ARL14 Gene

Gene Families for ARL14 Gene

HGNC:
  • ARF :ADP-ribosylation factors
  • ARL :ADP-ribosylation factors-like

Protein Domains for ARL14 Gene

Suggested Antigen Peptide Sequences for ARL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4G2

UniProtKB/Swiss-Prot:

ARL14_HUMAN :
  • Q8N4G2
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL14: view

Function for ARL14 Gene

Molecular function for ARL14 Gene

UniProtKB/Swiss-Prot Function: GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.

Gene Ontology (GO) - Molecular Function for ARL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity --
GO:0004871 signal transducer activity --
GO:0005515 protein binding IPI 21458045
GO:0005525 GTP binding IEA --
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with ARL14: view

Phenotypes for ARL14 Gene

GenomeRNAi human phenotypes for ARL14:
genes like me logo Genes that share phenotypes with ARL14: view

Animal Model Products

CRISPR Products

miRNA for ARL14 Gene

miRTarBase miRNAs that target ARL14

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL14

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARL14 Gene

Localization for ARL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL14 Gene

Cytoplasmic vesicle. Note=Colocalizes with MHC II-containing cytoplasmic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL14 Gene COMPARTMENTS Subcellular localization image for ARL14 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm --
GO:0016023 cytoplasmic membrane-bounded vesicle IEA --
GO:0031410 cytoplasmic vesicle --
genes like me logo Genes that share ontologies with ARL14: view

Pathways for ARL14 Gene

SuperPathways for ARL14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with ARL14: view

No data available for Pathways by source for ARL14 Gene

Transcripts for ARL14 Gene

mRNA/cDNA for ARL14 Gene

(17) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL14 Gene

ADP-ribosylation factor-like 14:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL14

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARL14
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL14 Gene

No ASD Table

Relevant External Links for ARL14 Gene

GeneLoc Exon Structure for
ARL14
ECgene alternative splicing isoforms for
ARL14

Expression for ARL14 Gene

mRNA expression in normal human tissues for ARL14 Gene

mRNA differential expression in normal tissues according to GTEx for ARL14 Gene

This gene is overexpressed in Stomach (18.6), Colon - Transverse (15.8), Pancreas (5.4), Small Intestine - Terminal Ileum (5.0), and Bladder (4.8).

SOURCE GeneReport for Unigene cluster for ARL14 Gene Hs.287702

mRNA Expression by UniProt/SwissProt for ARL14 Gene

Q8N4G2-ARL14_HUMAN
Tissue specificity: Expressed in immature dendritic cells.
genes like me logo Genes that share expressions with ARL14: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for ARL14 Gene

Orthologs for ARL14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL14 35
  • 99.48 (n)
  • 98.96 (a)
ARL14 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARL14 35
  • 84.55 (n)
  • 83.33 (a)
ARL14 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL14 35
  • 88.02 (n)
  • 86.46 (a)
ARL14 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl14 35
  • 78.77 (n)
  • 75.79 (a)
Arl14 16
Arl14 36
  • 75 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL14 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARL14 36
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl14 35
  • 79.65 (n)
  • 77.89 (a)
chicken
(Gallus gallus)
Aves ARL14 36
  • 62 (a)
OneToOne
LOC101749876 35
  • 65.07 (n)
  • 62.23 (a)
lizard
(Anolis carolinensis)
Reptilia ARL14 36
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl14 35
  • 67.19 (n)
  • 64.06 (a)
zebrafish
(Danio rerio)
Actinopterygii arl14 35
  • 57.66 (n)
  • 56.9 (a)
arl14 36
  • 49 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 36
  • 36 (a)
OneToMany
Species with no ortholog for ARL14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL14 Gene

ENSEMBL:
Gene Tree for ARL14 (if available)
TreeFam:
Gene Tree for ARL14 (if available)

Paralogs for ARL14 Gene

Paralogs for ARL14 Gene

Selected SIMAP similar genes for ARL14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL14: view

Variants for ARL14 Gene

Sequence variations from dbSNP and Humsavar for ARL14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs1879797 -- 160,677,305(-) TTTTT(C/T)TTTCT utr-variant-5-prime
rs4133252 -- 160,678,652(+) GCTTA(G/T)CTCTA downstream-variant-500B
rs4133253 -- 160,678,671(+) CCCCG(A/G)GTCTT downstream-variant-500B
rs6764067 -- 160,676,364(+) ggttt(C/T)accat upstream-variant-2KB
rs6799843 -- 160,676,234(+) gatct(C/T)ggctc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARL14 Gene

Variant ID Type Subtype PubMed ID
nsv877703 CNV Gain 21882294

Relevant External Links for ARL14 Gene

HapMap Linkage Disequilibrium report
ARL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL14 Gene

Disorders for ARL14 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARL14 Gene including...

Search for ARL14 Gene in MalaCards »

Relevant External Links for ARL14

Genetic Association Database (GAD)
ARL14
genes like me logo Genes that share disorders with ARL14: view

No data available for UniProtKB/Swiss-Prot for ARL14 Gene

Publications for ARL14 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Human RAS superfamily proteins and related GTPases. (PMID: 15367757) Colicelli J. (Sci. STKE 2004) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. (PMID: 21458045) Paul P. … Neefjes J. (Cell 2011) 3 4
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for ARL14 Gene

Sources for ARL14 Gene

Back to Top

Content