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Aliases for ARL14 Gene

Aliases for ARL14 Gene

  • ADP Ribosylation Factor Like GTPase 14 2 3 5
  • ADP-Ribosylation Factor 7 2 3 4
  • ARF7 3 4
  • ADP-Ribosylation Factor-Like Protein 14 3
  • ADP-Ribosylation Factor Like GTPase 14 2
  • ADP-Ribosylation Factor-Like 14 3

External Ids for ARL14 Gene

Previous HGNC Symbols for ARL14 Gene

  • ARF7

Previous GeneCards Identifiers for ARL14 Gene

  • GC03P161881
  • GC03P160394
  • GC03P157793

Summaries for ARL14 Gene

GeneCards Summary for ARL14 Gene

ARL14 (ADP Ribosylation Factor Like GTPase 14) is a Protein Coding gene. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL11.

UniProtKB/Swiss-Prot for ARL14 Gene

  • GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL14 Gene

Genomics for ARL14 Gene

Regulatory Elements for ARL14 Gene

Enhancers for ARL14 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F160616 0.2 Ensembl 10 -60.2 -60159 0.4 ARL14 GC03P160584
GH03F160885 0.7 Ensembl ENCODE 9.8 +208.8 208816 1.4 PKNOX1 TBL1XR1 INSM2 KLF17 GLIS2 KLF7 CREM ZNF280D ZEB2 SP1 SPTSSB ARL14 B3GALNT1 PIR58593 PPM1L
GH03F160935 0.8 ENCODE 9.8 +258.4 258409 0.2 SOX13 ELF3 CEBPG ZNF48 ZNF644 RAD21 DNMT3B YY1 ZNF664 GATA3 PPM1L ARL14 PIR58593
GH03F160675 1 Ensembl ENCODE 0.8 +0.8 798 4.8 ELF3 HDAC1 NFRKB ARID4B RAD21 RFX5 ZNF335 ZNF366 RCOR1 FOS KPNA4 IFT80 ARL14 ENSG00000207084
GH03F160672 0.5 ENCODE 0.8 -5.0 -4972 0.2 ARL14 GC03P160584
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARL14 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL14 Gene

Chromosome:
3
Start:
160,677,159 bp from pter
End:
160,678,452 bp from pter
Size:
1,294 bases
Orientation:
Plus strand

Genomic View for ARL14 Gene

Genes around ARL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL14 Gene

Proteins for ARL14 Gene

  • Protein details for ARL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4G2-ARL14_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 14
    Protein Accession:
    Q8N4G2
    Secondary Accessions:
    • Q9H655

    Protein attributes for ARL14 Gene

    Size:
    192 amino acids
    Molecular mass:
    21588 Da
    Quaternary structure:
    • Interacts with ARL14EP.

neXtProt entry for ARL14 Gene

Post-translational modifications for ARL14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL14 Gene

Domains & Families for ARL14 Gene

Gene Families for ARL14 Gene

Suggested Antigen Peptide Sequences for ARL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4G2

UniProtKB/Swiss-Prot:

ARL14_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL14: view

Function for ARL14 Gene

Molecular function for ARL14 Gene

UniProtKB/Swiss-Prot Function:
GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.

Gene Ontology (GO) - Molecular Function for ARL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21458045
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL14: view
genes like me logo Genes that share phenotypes with ARL14: view

Animal Model Products

miRNA for ARL14 Gene

miRTarBase miRNAs that target ARL14

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL14

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL14 Gene

Localization for ARL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL14 Gene

Cytoplasmic vesicle. Note=Colocalizes with MHC II-containing cytoplasmic vesicles.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL14 Gene COMPARTMENTS Subcellular localization image for ARL14 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for ARL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with ARL14: view

Pathways & Interactions for ARL14 Gene

SuperPathways for ARL14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL14: view

No data available for Pathways by source and SIGNOR curated interactions for ARL14 Gene

Transcripts for ARL14 Gene

mRNA/cDNA for ARL14 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL14 Gene

ADP-ribosylation factor-like 14:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL14

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL14 Gene

No ASD Table

Relevant External Links for ARL14 Gene

GeneLoc Exon Structure for
ARL14
ECgene alternative splicing isoforms for
ARL14

Expression for ARL14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARL14 Gene

This gene is overexpressed in Stomach (x18.6), Colon - Transverse (x15.8), Pancreas (x5.4), Small Intestine - Terminal Ileum (x5.0), and Bladder (x4.8).

NURSA nuclear receptor signaling pathways regulating expression of ARL14 Gene:

ARL14

SOURCE GeneReport for Unigene cluster for ARL14 Gene:

Hs.287702

mRNA Expression by UniProt/SwissProt for ARL14 Gene:

Q8N4G2-ARL14_HUMAN
Tissue specificity: Expressed in immature dendritic cells.
genes like me logo Genes that share expression patterns with ARL14: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ARL14 Gene

Orthologs for ARL14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL14 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL14 34 35
  • 99.48 (n)
dog
(Canis familiaris)
Mammalia ARL14 34 35
  • 88.02 (n)
cow
(Bos Taurus)
Mammalia ARL14 34 35
  • 84.55 (n)
rat
(Rattus norvegicus)
Mammalia Arl14 34
  • 79.65 (n)
mouse
(Mus musculus)
Mammalia Arl14 34 16 35
  • 78.77 (n)
oppossum
(Monodelphis domestica)
Mammalia ARL14 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARL14 35
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC101749876 34
  • 65.07 (n)
ARL14 35
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL14 35
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl14 34
  • 67.19 (n)
zebrafish
(Danio rerio)
Actinopterygii arl14 34 35
  • 57.66 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 35
  • 36 (a)
OneToMany
Species where no ortholog for ARL14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL14 Gene

ENSEMBL:
Gene Tree for ARL14 (if available)
TreeFam:
Gene Tree for ARL14 (if available)

Paralogs for ARL14 Gene

Paralogs for ARL14 Gene

(28) SIMAP similar genes for ARL14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL14: view

Variants for ARL14 Gene

Sequence variations from dbSNP and Humsavar for ARL14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10537799 -- 160,676,193(+) ACGGA(-/GT)GTCTC upstream-variant-2KB
rs111444152 -- 160,677,304(+) AGAAA(-/G/GAAAG)AAAAA utr-variant-5-prime
rs112491968 -- 160,675,895(+) GAGGG(-/GTGT)GTGTG upstream-variant-2KB
rs112722139 -- 160,675,881(+) GAAGA(C/T)ACCCA upstream-variant-2KB
rs114603081 -- 160,678,732(+) CTCAT(C/T)GTACT downstream-variant-500B

Variation tolerance for ARL14 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL14

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARL14 Gene

Disorders for ARL14 Gene

Relevant External Links for ARL14

Genetic Association Database (GAD)
ARL14
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL14

No disorders were found for ARL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL14 Gene

Publications for ARL14 Gene

  1. A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. (PMID: 21458045) Paul P. … Neefjes J. (Cell 2011) 3 4 64
  2. Human RAS superfamily proteins and related GTPases. (PMID: 15367757) Colicelli J. (Sci. STKE 2004) 2 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation. (PMID: 24583629) Senapati S. … Thelma B.K. (Pharmacogenet. Genomics 2014) 3 64

Products for ARL14 Gene

Sources for ARL14 Gene

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