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Aliases for ARL14 Gene

Aliases for ARL14 Gene

  • ADP Ribosylation Factor Like GTPase 14 2 3 5
  • ADP-Ribosylation Factor 7 2 3 4
  • ADP-Ribosylation Factor Like GTPase 14 2 3
  • ARF7 3 4
  • ADP-Ribosylation Factor-Like 14 3

External Ids for ARL14 Gene

Previous HGNC Symbols for ARL14 Gene

  • ARF7

Previous GeneCards Identifiers for ARL14 Gene

  • GC03P161881
  • GC03P160394
  • GC03P157793

Summaries for ARL14 Gene

GeneCards Summary for ARL14 Gene

ARL14 (ADP Ribosylation Factor Like GTPase 14) is a Protein Coding gene. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL11.

UniProtKB/Swiss-Prot for ARL14 Gene

  • GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL14 Gene

Genomics for ARL14 Gene

Regulatory Elements for ARL14 Gene

Enhancers for ARL14 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARL14 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARL14 Gene

160,677,159 bp from pter
160,678,452 bp from pter
1,294 bases
Plus strand

Genomic View for ARL14 Gene

Genes around ARL14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL14 Gene

Proteins for ARL14 Gene

  • Protein details for ARL14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 14
    Protein Accession:
    Secondary Accessions:
    • Q9H655

    Protein attributes for ARL14 Gene

    192 amino acids
    Molecular mass:
    21588 Da
    Quaternary structure:
    • Interacts with ARL14EP.

neXtProt entry for ARL14 Gene

Proteomics data for ARL14 Gene at MOPED

Post-translational modifications for ARL14 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL14 Gene

Domains & Families for ARL14 Gene

Gene Families for ARL14 Gene

Protein Domains for ARL14 Gene

Suggested Antigen Peptide Sequences for ARL14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL14: view

Function for ARL14 Gene

Molecular function for ARL14 Gene

UniProtKB/Swiss-Prot Function:
GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells.

Gene Ontology (GO) - Molecular Function for ARL14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21458045
genes like me logo Genes that share ontologies with ARL14: view
genes like me logo Genes that share phenotypes with ARL14: view

Animal Model Products

CRISPR Products

miRNA for ARL14 Gene

miRTarBase miRNAs that target ARL14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL14 Gene

Localization for ARL14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL14 Gene

Cytoplasmic vesicle. Note=Colocalizes with MHC II-containing cytoplasmic vesicles.

Subcellular locations from

Jensen Localization Image for ARL14 Gene COMPARTMENTS Subcellular localization image for ARL14 gene
Compartment Confidence
cytosol 3
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for ARL14 Gene

Pathways & Interactions for ARL14 Gene

SuperPathways for ARL14 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL14 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARL14 Gene

Drugs & Compounds for ARL14 Gene

No Compound Related Data Available

Transcripts for ARL14 Gene

mRNA/cDNA for ARL14 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(17) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL14 Gene

ADP-ribosylation factor-like 14:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARL14 Gene

No ASD Table

Relevant External Links for ARL14 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL14 Gene

mRNA expression in normal human tissues for ARL14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARL14 Gene

This gene is overexpressed in Stomach (x18.6), Colon - Transverse (x15.8), Pancreas (x5.4), Small Intestine - Terminal Ileum (x5.0), and Bladder (x4.8).

SOURCE GeneReport for Unigene cluster for ARL14 Gene Hs.287702

mRNA Expression by UniProt/SwissProt for ARL14 Gene

Tissue specificity: Expressed in immature dendritic cells.
genes like me logo Genes that share expression patterns with ARL14: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for ARL14 Gene

Orthologs for ARL14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL14 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARL14 35
  • 84.55 (n)
  • 83.33 (a)
ARL14 36
  • 83 (a)
(Canis familiaris)
Mammalia ARL14 35
  • 88.02 (n)
  • 86.46 (a)
ARL14 36
  • 82 (a)
(Mus musculus)
Mammalia Arl14 35
  • 78.77 (n)
  • 75.79 (a)
Arl14 16
Arl14 36
  • 75 (a)
(Pan troglodytes)
Mammalia ARL14 35
  • 99.48 (n)
  • 98.96 (a)
ARL14 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Arl14 35
  • 79.65 (n)
  • 77.89 (a)
(Monodelphis domestica)
Mammalia ARL14 36
  • 70 (a)
(Ornithorhynchus anatinus)
Mammalia ARL14 36
  • 69 (a)
(Gallus gallus)
Aves LOC101749876 35
  • 65.07 (n)
  • 62.23 (a)
ARL14 36
  • 62 (a)
(Anolis carolinensis)
Reptilia ARL14 36
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arl14 35
  • 67.19 (n)
  • 64.06 (a)
(Danio rerio)
Actinopterygii arl14 35
  • 57.66 (n)
  • 56.9 (a)
arl14 36
  • 49 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 36
  • 36 (a)
Species with no ortholog for ARL14:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL14 Gene

Gene Tree for ARL14 (if available)
Gene Tree for ARL14 (if available)

Paralogs for ARL14 Gene

Paralogs for ARL14 Gene

(28) SIMAP similar genes for ARL14 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL14: view

Variants for ARL14 Gene

Sequence variations from dbSNP and Humsavar for ARL14 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs35634980 - 160,677,593(-) CCCAT(C/T)GGTGT reference, missense
rs35633732 - 160,677,695(-) AACAG(A/G/T)CACAT reference, missense
rs1879797 -- 160,677,305(-) TTTTT(C/T)TTTCT utr-variant-5-prime
rs7610939 -- 160,675,757(+) gactt(A/T)ggcat upstream-variant-2KB
rs6764067 -- 160,676,364(+) ggttt(C/T)accat upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARL14 Gene

Variant ID Type Subtype PubMed ID
nsv877703 CNV Gain 21882294

Variation tolerance for ARL14 Gene

Residual Variation Intolerance Score: 84.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.83; 58.59% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARL14 Gene

Disorders for ARL14 Gene

Relevant External Links for ARL14

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARL14 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL14 Gene

Publications for ARL14 Gene

  1. A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. (PMID: 21458045) Paul P. … Neefjes J. (Cell 2011) 3 4 67
  2. Human RAS superfamily proteins and related GTPases. (PMID: 15367757) Colicelli J. (Sci. STKE 2004) 2 3
  3. Genome-wide analysis of methotrexate pharmacogenomics in rheumatoid arthritis shows multiple novel risk variants and leads for TYMS regulation. (PMID: 24583629) Senapati S. … Thelma B.K. (Pharmacogenet. Genomics 2014) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3
  5. Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. (PMID: 19458352) Hirschfield G.M. … Siminovitch K.A. (N. Engl. J. Med. 2009) 3

Products for ARL14 Gene

Sources for ARL14 Gene