ARL14 Gene
protein-coding GIFtS: 47
GCID: GC03P160394
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ADP-ribosylation factor-like 14(Previous name: ADP-ribosylation factor 7 )
(Previous symbol: ARF7)
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Aliases
for ARL14 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADP-Ribosylation Factor-Like 141 2 | | ARF71 2 3 | | ADP-Ribosylation Factor 71 2 3 | | FLJ225951 | | ADP-Ribosylation Factor-Like Protein 142 |
Export aliases for ARL14 gene to outside databasesPrevious GC identifers: GC03P161881 GC03P157793 |
Summaries
for ARL14 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ARL14_HUMAN, Q8N4G2Function: GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hencecontrols the movement of these vesicles along the actin cytoskeleton in dendritic cells
|
Genomic Views
for ARL14 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARL14 gene promoter:
CHOP-10 AP-4 Evi-1 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARL14
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL14 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q25.33 Ensembl cytogenetic band: 3q25.33 HGNC cytogenetic band: 3q25.33ARL14 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P160394: view genomic region
(about GC identifiers)
Start:
|
160,394,948 bp from pter |
End:
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160,396,236 bp from pter |
Size:
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1,289 bases |
Orientation:
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plus strand |
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Proteins
for ARL14 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARL14_HUMAN, Q8N4G2 (See
protein sequence)Recommended Name: ADP-ribosylation factor-like protein 14 Size: 192 amino acids; 21588 Da
Subunit: Interacts with ARL14EP
Subcellular location: Cytoplasmic vesicle. Note=Colocalizes with MHC II-containing cytoplasmic vesicles
Secondary accessions: Q9H655Explore the universe of human proteins at neXtProt for ARL14: NX_Q8N4G2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N4G2
ARL14 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079323.1
ENSEMBL proteins: ENSP00000323847
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016023 | cytoplasmic membrane-bounded vesicle |
IEA | -- |
ARL14 for ontologies About GeneDecksing
ARL14 Antibody Products:
Assay Products for ARL14: |
Protein
Domains /
Families
for ARL14 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARL14 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8N4G2ProtoNet protein and cluster: Q8N4G2 1 Blocks protein family: IPB006688 ADP-ribosylation factor
UniProtKB/Swiss-Prot: ARL14_HUMAN, Q8N4G2Similarity: Belongs to the small GTPase superfamily. Arf family |
Function
for ARL14 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARL14_HUMAN, Q8N4G2Function: GTPase that recruits MYO1E to MHC class II-containing vesicles via the effector protein ARL14EP and hencecontrols the movement of these vesicles along the actin cytoskeleton in dendritic cells
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL14 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL14 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARL14 (NM_025047) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARL14 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL14 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL14 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ARL14 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ARL14:
|
Pathways & Interactions
for ARL14 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL14
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/7 Interacting proteins for ARL14 (Q8N4G21, 3 ENSP000003238474) via UniProtKB, MINT, STRING, and/or I2D (see all 7)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- |
ARL14 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARL14 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARL14
Search CenterWatch for drugs/clinical trials and news about ARL14
|
Transcripts
for ARL14 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARL14 gene: NM_025047.2 Unigene Cluster for ARL14: ADP-ribosylation factor-like 14 Hs.287702 [show with all ESTs]Unigene Representative Sequence: NM_0250471 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000320767(uc003fdq.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL14 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL14 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARL14 (NM_025047) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARL14 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL14 |
Additional cDNA sequence: AK026248.1 BC034354.1 1 DOTS entry: DT.97837976 17 AceView cDNA sequences: BM784879 BM856074 BC034354 AK026248 BG675911 BM761727 BE615082 BM760777 CB139850 BM843501 CB129504 BG248272 NM_025047 BE615843 BM844581 BG290194 CB120156
GeneLoc Exon Structure
|
Expression
for ARL14 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARL14 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCAAATGAGG
About this image
See ARL14 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARL14
SOURCE GeneReport for Unigene cluster: Hs.287702
UniProtKB/Swiss-Prot: ARL14_HUMAN, Q8N4G2Tissue specificity: Expressed in immature dendritic cells
SABiosciences Custom PCR Arrays for ARL14
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL14
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARL14 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL14 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL14 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL14 |
Orthologs
for ARL14 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ARL14 gene from 3/11 species (see all 11) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
E1BTK4_CHICK6 |
Uncharacterized protein |
60(a) |
1 ↔ 1 |
9(23660717-23661301) |
lizard
(Anolis carolinensis) |
Reptilia |
ARL146 |
-- |
64(a) |
1 ↔ 1 |
3(12912732-12913310) |
zebrafish
(Danio rerio) |
Actinopterygii |
arl141 |
ADP-ribosylation factor-like 14 |
57.85(n)
56.9(a) |
|
556921 NM_001099983.1 NP_001093453.1 |
ENSEMBL Gene Tree for ARL14 (if available)
TreeFam Gene Tree for ARL14 (if available) |
Paralogs
for ARL14 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARL14 gene
- ARL4A2 ARL112 ARF42 ARF52 ARF12 ARL4D2 ARF32 ARF62
- ARL92 ARL17B2 ARL4C2 TRIM232 ARL102
18/28 SIMAP similar genes for ARL14 using alignment to 1 protein entry: ARL14_HUMAN(see all similar genes):ARF1 ARF3 ARF6 ARF5 TRIM23 ARF4
ARL5A ARL3 ARL5B ARL11 ARL4C ARL7
ARL4A ARL2 ARL1 ARL4D ARL6 ARL8B
ARL14 for paralogs About GeneDecksing
|
Genomic Variants
for ARL14 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARL14 (160394948 - 160396236 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARL14: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL14 |
|
Disorders
/ Diseases
for ARL14 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARL14 for disorders About GeneDecksing
OMIM gene information: 614439
OMIM disorders: --
3  diseases for ARL14: About MalaCardsprimary biliary cirrhosis dyslexia malaria
Export disorders for ARL14 gene to outside databases
|
Publications
for ARL14 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARL14 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARL14) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Human RAS superfamily proteins and related GTPases. (PubMed id 15367757)1, 3 Colicelli J. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A Genome-wide multidimensional RNAi screen reveals pathways controlling MHC class II antigen presentation. (PubMed id 21458045)2 Paul P.... Neefjes J. (2011)
- Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants. (PubMed id 19458352)1 Hirschfield G.M....Siminovitch K.A. (2009)
- The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (2006)
- High-throughput mapping of a dynamic signaling network in mammalian cells. (PubMed id 15761153)1 Barrios-Rodiles M....Wrana J.L. (2005)
- Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for ARL14 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARL14 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARL14 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARL14 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARL14 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARL14 gene:
Search GeneIP for patents involving ARL14
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARL14 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ARL14 | | OriGene shRNA RFP for ARL14 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL14 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL14 | | | OriGene Protein Over-expression Lysate for ARL14 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARL14 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL14 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL14 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ARL14 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARL14 | | OriGene Custom Protein Services for ARL14 | | | OriGene Custom Immunoassay Development | | |
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| |
 |  |  |  | |
| | | | Search Tocris compounds for ARL14 |
| |  |  |  |  | | | | | | Recombinant Protein for ARL14 |
|
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 |
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 | | | ARL14 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL14 |
|  |  |  | | | | ThermoFisher Antibody for ARL14 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL14 |
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