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Aliases for ARL11 Gene

Aliases for ARL11 Gene

  • ADP Ribosylation Factor Like GTPase 11 2 3 5
  • ADP-Ribosylation Factor-Like Tumor Suppressor Protein 1 3 4
  • ADP-Ribosylation Factor-Like Tumor Suppressor Gene 1 2 3
  • ARLTS1 3 4
  • ADP-Ribosylation Factor-Like Protein 11 3
  • ADP-Ribosylation Factor Like GTPase 11 2
  • ADP-Ribosylation Factor-Like 11 3

External Ids for ARL11 Gene

Previous GeneCards Identifiers for ARL11 Gene

  • GC13P048000
  • GC13P049100
  • GC13P050202
  • GC13P030995

Summaries for ARL11 Gene

Entrez Gene Summary for ARL11 Gene

  • This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]

GeneCards Summary for ARL11 Gene

ARL11 (ADP Ribosylation Factor Like GTPase 11) is a Protein Coding gene. Diseases associated with ARL11 include Ovarian Cystadenocarcinoma and Chronic Lymphocytic Leukemia. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL14.

UniProtKB/Swiss-Prot for ARL11 Gene

  • May play a role in apoptosis. May act as a tumor suppressor.

Gene Wiki entry for ARL11 Gene

Additional gene information for ARL11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL11 Gene

Genomics for ARL11 Gene

Regulatory Elements for ARL11 Gene

Enhancers for ARL11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH13H049640 1.5 FANTOM5 Ensembl ENCODE 12.9 +14.3 14290 3.2 HDAC1 TAL1 ZNF133 JUN ZNF175 EBF1 CEBPG FOSL1 TCF12 GATA3 PHF11 RCBTB1 ARL11 EBPL KPNA3 SETDB2 CAB39L LOC105370205 GC13M049652
GH13H049442 1.6 Ensembl ENCODE dbSUPER 10.8 -182.7 -182673 5.5 HDGF PKNOX1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF766 PHF11 SETDB2 CAB39L ARL11 EBPL SNRPGP14
GH13H049606 1.1 Ensembl ENCODE 13.3 -21.0 -20992 1 SOX13 CTCF SAP130 ARID4B MAX ZNF2 RAD21 YY1 CTBP1 POLR2A RCBTB1 ARL11 PHF11 EBPL GC13P049617
GH13H049619 0.8 Ensembl ENCODE 15.5 -8.4 -8435 1.7 SP1 POLR2A ZNF407 MAX RUNX3 MYC RCBTB1 ARL11 EBPL KPNA3 ENSG00000176882 GC13P049618
GH13H049649 0.9 Ensembl ENCODE 13 +23.1 23090 4.2 CTCF ZNF654 KLF1 ZNF740 REST RAD21 TEAD3 PATZ1 SMC3 FOS EBPL ARL11 KPNA3 PHF11 RCBTB1 GC13M049652 LOC105370205
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL11 on UCSC Golden Path with GeneCards custom track

Promoters for ARL11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for ARL11 Gene

Genomic Locations for ARL11 Gene
5,574 bases
Plus strand

Genomic View for ARL11 Gene

Genes around ARL11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL11 Gene

Proteins for ARL11 Gene

  • Protein details for ARL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    ADP-ribosylation factor-like protein 11
    Protein Accession:

    Protein attributes for ARL11 Gene

    196 amino acids
    Molecular mass:
    21391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL11 Gene

Post-translational modifications for ARL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL11 Gene

Domains & Families for ARL11 Gene

Gene Families for ARL11 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for ARL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Arf family.
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL11: view

Function for ARL11 Gene

Molecular function for ARL11 Gene

UniProtKB/Swiss-Prot Function:
May play a role in apoptosis. May act as a tumor suppressor.

Phenotypes From GWAS Catalog for ARL11 Gene

Gene Ontology (GO) - Molecular Function for ARL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL11: view
genes like me logo Genes that share phenotypes with ARL11: view

Clone Products

  • Addgene plasmids for ARL11

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL11 Gene

Localization for ARL11 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL11 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
mitochondrion 2
extracellular 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ARL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARL11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARL11 Gene

Pathways & Interactions for ARL11 Gene

SuperPathways for ARL11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL11: view

No data available for Pathways by source and SIGNOR curated interactions for ARL11 Gene

Drugs & Compounds for ARL11 Gene

No Compound Related Data Available

Transcripts for ARL11 Gene

mRNA/cDNA for ARL11 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL11 Gene

ADP-ribosylation factor-like 11:
Representative Sequences:

Clone Products

  • Addgene plasmids for ARL11

Alternative Splicing Database (ASD) splice patterns (SP) for ARL11 Gene

No ASD Table

Relevant External Links for ARL11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARL11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL11 Gene

mRNA differential expression in normal tissues according to GTEx for ARL11 Gene

This gene is overexpressed in Whole Blood (x31.0).

Protein differential expression in normal tissues from HIPED for ARL11 Gene

This gene is overexpressed in Monocytes (39.3) and Spleen (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL11 Gene

Protein tissue co-expression partners for ARL11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL11 Gene:


SOURCE GeneReport for Unigene cluster for ARL11 Gene:


mRNA Expression by UniProt/SwissProt for ARL11 Gene:

Tissue specificity: Expressed in lung and leukocytes.

Evidence on tissue expression from TISSUES for ARL11 Gene

  • Spleen(4.2)
  • Bone marrow(4.1)
  • Lung(2.3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL11 Gene

Germ Layers:
  • mesoderm
  • immune
  • lymphatic
  • blood
  • bone marrow
  • white blood cell
genes like me logo Genes that share expression patterns with ARL11: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ARL11 Gene

Orthologs for ARL11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARL11 34 33
  • 99.15 (n)
(Mus musculus)
Mammalia Arl11 16 34 33
  • 83.9 (n)
(Rattus norvegicus)
Mammalia Arl11 33
  • 81.7 (n)
(Bos Taurus)
Mammalia ARL11 34 33
  • 80.7 (n)
(Ornithorhynchus anatinus)
Mammalia ARL11 34
  • 68 (a)
(Monodelphis domestica)
Mammalia ARL11 34
  • 66 (a)
(Gallus gallus)
Aves ARL11 34 33
  • 61.88 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490310 33
  • 60.54 (n)
(Danio rerio)
Actinopterygii arl11 34 33
  • 56.7 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 34
  • 38 (a)
Species where no ortholog for ARL11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL11 Gene

Gene Tree for ARL11 (if available)
Gene Tree for ARL11 (if available)

Paralogs for ARL11 Gene

Paralogs for ARL11 Gene

(27) SIMAP similar genes for ARL11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL11: view

Variants for ARL11 Gene

Sequence variations from dbSNP and Humsavar for ARL11 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
rs1000262385 -- 49,628,502(+) CGGCT(G/T)CTCTG utr-variant-5-prime
rs1000647150 -- 49,628,732(+) CTCTT(C/T)TCTGT intron-variant
rs1000761441 -- 49,628,483(+) CAAAA(-/AGG)AGAAG cds-indel, utr-variant-5-prime
rs1001383569 -- 49,627,119(+) AGAGA(C/G)AGAGT upstream-variant-2KB
rs1002677055 -- 49,626,795(+) TTTTT(C/T)TGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARL11 Gene

Variant ID Type Subtype PubMed ID
esv3632050 CNV gain 21293372

Variation tolerance for ARL11 Gene

Residual Variation Intolerance Score: 86.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL11 Gene

Disorders for ARL11 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ARL11 Gene - From: HGMD, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ovarian cystadenocarcinoma
  • cystadenocarcinoma of ovary
chronic lymphocytic leukemia
  • b-cell chronic lymphocytic leukemia
chronic leukemia
  • adult chronic leukemia
dysplastic nevus syndrome
  • familial atypical multiple mole-melanoma
ovary adenocarcinoma
  • adenocarcinoma of the ovary
- elite association - COSMIC cancer census association via MalaCards
Search ARL11 in MalaCards View complete list of genes associated with diseases


  • Leukemia, chronic lymphocytic (CLL) [MIM:151400]: A chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ARL11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARL11: view

No data available for Genatlas for ARL11 Gene

Publications for ARL11 Gene

  1. Association of the ARLTS1 Cys148Arg variant with familial breast cancer risk. (PMID: 16353159) Frank B … Burwinkel B (International journal of cancer 2006) 3 22 45 60
  2. Familial cancer associated with a polymorphism in ARLTS1. (PMID: 15843669) Calin GA … Croce CM (The New England journal of medicine 2005) 3 4 45 60
  3. ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer. (PMID: 20358297) Akisik E … Dalay N (Molecular biology reports 2011) 3 45 60
  4. Association of the ARLTS1 variants with familial ovarian cancer risk in China. (PMID: 19509554) Yang XY … Peng ZL (International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2009) 3 45 60
  5. ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer. (PMID: 18337727) Siltanen S … Vahteristo P (European journal of human genetics : EJHG 2008) 3 45 60

Products for ARL11 Gene

Sources for ARL11 Gene

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