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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL11 Gene

protein-coding   GIFtS: 56
GCID: GC13P050202

ADP-Ribosylation Factor-Like 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
ADP-Ribosylation Factor-Like 111 2
ARLTS12 3 5
ADP-Ribosylation Factor-Like Tumor Suppressor Protein 12 3
ADP-Ribosylation Factor-Like Protein 112

External Ids:    HGNC: 240461   Entrez Gene: 1157612   Ensembl: ENSG000001522137   OMIM: 6093515   UniProtKB: Q969Q43   

Export aliases for ARL11 gene to outside databases

Previous GC identifers: GC13P048000 GC13P049100 GC13P030995


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARL11 Gene:
This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded
protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been
associated with some familial cancers. (provided by RefSeq, May 2010)

GeneCards Summary for ARL11 Gene: 
ARL11 (ADP-ribosylation factor-like 11) is a protein-coding gene. Diseases associated with ARL11 include familial breast cancer, and familial colorectal cancer. GO annotations related to this gene include protein binding and GTP binding. An important paralog of this gene is ARL4A.

UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4
Function: May play a role in apoptosis. May act as a tumor suppressor

Gene Wiki entry for ARL11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NT_024524.14  NC_018924.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL11 gene promoter:
         GR   NF-1   AML1a   GR-beta   Pax-2   Lmo2   Pax-2a   Max   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL11 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.2   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.12

ARL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL11 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P050202:  view genomic region     (about GC identifiers)

Start:
50,202,435 bp from pter      End:
50,208,008 bp from pter
Size:
5,574 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 11  
Size: 196 amino acids; 21391 Da

Explore the universe of human proteins at neXtProt for ARL11: NX_Q969Q4

Explore proteomics data for ARL11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q969Q4

  • ARL11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARL11 Protein Expression
    REFSEQ proteins: NP_612459.1  
    ENSEMBL proteins: 
     ENSP00000282026  

    Human Recombinant Protein Products for ARL11: 
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    ProSpec Recombinant Protein for ARL11
    Cloud-Clone Corp. Proteins for ARL11 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----

    ARL11 for ontologies           About GeneDecksing



    ARL11 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARL: ADP-ribosylation factors-like

    4 InterPro protein domains:
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry Q969Q4

    ProtoNet protein and cluster: Q969Q4

    1 Blocks protein domain: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL11_HUMAN, Q969Q4
    Function: May play a role in apoptosis. May act as a tumor suppressor

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0005525GTP binding IEA--
         
    ARL11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARL11:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARL11 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARL11

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    SwitchGear 3'UTR luciferase reporter plasmidARL11 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL11

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for ARL11 (Q969Q41, 2, 3 ENSP000002820264) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156451, 2, 3, ENSP000001663454EBI-751892,EBI-358993 MINT-68304 I2D: score=4 STRING: ENSP00000166345
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ----
    GO:0007264small GTPase mediated signal transduction IEA--

    ARL11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARL11

    Search CenterWatch for drugs/clinical trials and news about ARL11

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARL11 gene: 
    NM_138450.5  

    Unigene Cluster for ARL11:

    ADP-ribosylation factor-like 11
    Hs.558599  [show with all ESTs]
    Unigene Representative Sequence: AF441378
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282026(uc001vdf.2) ENST00000490932
    miRNA
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    hsa-miR-3163 hsa-miR-3678-3p hsa-miR-4311 hsa-miR-513c hsa-miR-2115 hsa-miR-3622b-3p hsa-miR-1252 hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidARL11 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF441378.1 AK091249.1 BC013150.1 

    3 DOTS entries:

    DT.95071791  DT.75184292  DT.440437 

    22 AceView cDNA sequences:

    CR600646 BC013150 BM801294 AX746876 AK091249 BX337240 BF797894 AA058535 
    AI523278 AF441378 NM_138450 BQ065118 BX106716 BM475738 BG025694 BM146309 
    AA759085 BI021680 BM148903 BX337239 AI970339 AA057305 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGGAGGAG
    ARL11 Expression
    About this image


    See ARL11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL11

    SOURCE GeneReport for Unigene cluster: Hs.558599

    UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4
    Tissue specificity: Expressed in lung and leukocytes

        SABiosciences Custom PCR Arrays for ARL11
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for ARL11 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl111 , 5 ADP-ribosylation factor-like 111, 5 83.9(n)1
    86.36(a)1
      14 (32.66 cM)5
    2191441  NM_177337.31  NP_796311.21 
     613097535 
    chicken
    (Gallus gallus)
    Aves ARL111 ADP-ribosylation factor-like 11 61.88(n)
    56.32(a)
      418869  XM_417064.3  XP_417064.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arl111 ADP-ribosylation factor-like 11 56.7(n)
    44.25(a)
      324689  NM_199693.1  NP_955987.1 


    ENSEMBL Gene Tree for ARL11 (if available)
    TreeFam Gene Tree for ARL11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL11 gene
    ARL4A2  ARF42  ARF52  ARF12  ARL142  ARL4D2  ARF32  ARF62  
    ARL4C2  ARL8A2  TRIM232  ARL8B2  
    18/27 SIMAP similar genes for ARL11 using alignment to 1 protein entry:     ARL11_HUMAN(see all similar genes):
    ARL3    ARF3    ARF5    ARL14    ARF1    ARL2
    ARL5A    TRIM23    ARF4    ARF6    ARL4A    ARL4C
    ARL8B    SARA1    ARL6    ARL5B    ARL7    ARL8A

    ARL11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/174 SNPs in ARL11 are shown (see all 174)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343013441,2
    C,Funtested131149616(+) CTGCTG/AGGAGC 2 /* /W stg14Minor allele frequency- A:0.01NA EU 4709
    VAR_0237454
    ----see VAR_0237452 E K mis40--------
    VAR_0237424
    ----see VAR_0237422 S L mis40--------
    rs2000014031,2
    C--30994393(+) TTTTC-/TTTTTT 1 -- us2k10--------
    rs2007732761,2
    C--30995362(+) GCTAA-/TTTTTG 1 -- us2k10--------
    rs1433755321,2
    --31145050(+) CTGCTG/TCTTTT 1 -- us2k10--------
    rs574130931,2
    --31145100(+) TGGAGC/TGCAGT 1 -- us2k10--------
    rs1879346511,2
    --31145105(+) TGCAGC/TGGCGC 1 -- us2k10--------
    rs1930017831,2
    --31145109(+) GTGGCA/GCGATC 1 -- us2k10--------
    rs1467392911,2
    --31145286(+) TGTGAC/TCTGCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARL11 (50202435 - 50208008 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARL11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv900071CNV Gain21882294


    Human Gene Mutation Database (HGMD): ARL11
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL11
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609351    OMIM disorders: --

    UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4
  • Leukemia, chronic lymphocytic (CLL) [MIM:151400]: A chronic leukemia in which functionally incompetent
    B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of
    the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease
    and short survival. Note=Disease susceptibility is associated with variations affecting the gene represented in
    this entry

  • 12 diseases for ARL11:    About MalaCards
    familial breast cancer    familial colorectal cancer    dysplastic nevus syndrome    chronic lymphocytic leukemia
    colorectal cancer    ovarian cancer    lung cancer    breast cancer
    melanoma    leukemia    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ARL11:
    Dysplastic nevus syndrome

    ARL11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARL11
    Human Genome Epidemiology (HuGE) Navigator: ARL11 (12 documents)

    Export disorders for ARL11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL11 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with ARL11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Familial cancer associated with a polymorphism in ARLTS1. (PubMed id 15843669)1, 2, 4 Calin G.A.... Croce C.M. (2005)
    2. Association of the ARLTS1 Cys148Arg variant with familial breast cancer risk. (PubMed id 16353159)1, 4, 9 Frank B....Burwinkel B. (2006)
    3. ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer. (PubMed id 20358297)1, 4 Akisik E....Dalay N. (2010)
    4. Association of the ARLTS1 variants with familial ovar ian cancer risk in China. (PubMed id 19509554)1, 4 Yang X.Y....Peng Z.L. (2009)
    5. ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer. (PubMed id 18337727)1, 4 Siltanen S....Vahteristo P. (2008)
    6. Association of the ARLTS1 Cys148Arg variant with sporadic and familial colorectal cancer. (PubMed id 17449901)1, 4 Castellvi-Bel S....Pique J.M. (2007)
    7. No association of ARLTS1 polymorphisms and risk for familial chronic lymphocytic leukaemia. (PubMed id 17391501)1, 4 Ng D....Toro J.R. (2007)
    8. Relationship between ARLTS1 polymorphisms and risk of chronic lymphocytic leukemia. (PubMed id 16581122)1, 4 Sellick G.S....Houlston R.S. (2006)
    9. Cancer Familial Aggregation (CFA) and G446A polymorphism in ARLTS1 gene. (PubMed id 16570116)1, 4 Masojc B....Lubinski J. (2006)
    10. ARLTS1 variants and risk of colorectal cancer. (PubMed id 16488076)1, 4 Frank B....Burwinkel B. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115761 HGNC: 24046 AceView: ARL11 Ensembl:ENSG00000152213 euGenes: HUgn115761
    ECgene: ARL11 H-InvDB: ARL11

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARL11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARL11 gene:
    Search GeneIP for patents involving ARL11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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