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Aliases for ARL11 Gene

Aliases for ARL11 Gene

  • ADP-Ribosylation Factor-Like 11 2 3
  • ADP-Ribosylation Factor-Like Tumor Suppressor Protein 1 3 4
  • ARLTS1 3 4

External Ids for ARL11 Gene

Previous GeneCards Identifiers for ARL11 Gene

  • GC13P048000
  • GC13P049100
  • GC13P050202
  • GC13P030995

Summaries for ARL11 Gene

Entrez Gene Summary for ARL11 Gene

  • This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associated with some familial cancers. [provided by RefSeq, May 2010]

GeneCards Summary for ARL11 Gene

ARL11 (ADP-Ribosylation Factor-Like 11) is a Protein Coding gene. Diseases associated with ARL11 include ovarian cystadenocarcinoma and dysplastic nevus syndrome. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL14.

UniProtKB/Swiss-Prot for ARL11 Gene

  • May play a role in apoptosis. May act as a tumor suppressor.

Gene Wiki entry for ARL11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL11 Gene

Genomics for ARL11 Gene

Regulatory Elements for ARL11 Gene

Genomic Location for ARL11 Gene

Chromosome:
13
Start:
49,628,299 bp from pter
End:
49,633,872 bp from pter
Size:
5,574 bases
Orientation:
Plus strand

Genomic View for ARL11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL11 Gene

Proteins for ARL11 Gene

  • Protein details for ARL11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Q4-ARL11_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 11
    Protein Accession:
    Q969Q4

    Protein attributes for ARL11 Gene

    Size:
    196 amino acids
    Molecular mass:
    21391 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL11 Gene

Proteomics data for ARL11 Gene at MOPED

Post-translational modifications for ARL11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARL11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARL11 Gene

Domains & Families for ARL11 Gene

Gene Families for ARL11 Gene

Protein Domains for ARL11 Gene

Suggested Antigen Peptide Sequences for ARL11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969Q4

UniProtKB/Swiss-Prot:

ARL11_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL11: view

Function for ARL11 Gene

Molecular function for ARL11 Gene

UniProtKB/Swiss-Prot Function:
May play a role in apoptosis. May act as a tumor suppressor.

Gene Ontology (GO) - Molecular Function for ARL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL11: view
genes like me logo Genes that share phenotypes with ARL11: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL11 Gene

Localization for ARL11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL11 Gene COMPARTMENTS Subcellular localization image for ARL11 gene
Compartment Confidence
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for ARL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARL11: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARL11 Gene

Pathways & Interactions for ARL11 Gene

SuperPathways for ARL11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0006886 intracellular protein transport --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL11: view

No data available for Pathways by source and SIGNOR curated interactions for ARL11 Gene

Drugs & Compounds for ARL11 Gene

No Compound Related Data Available

Transcripts for ARL11 Gene

mRNA/cDNA for ARL11 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(22) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARL11 Gene

ADP-ribosylation factor-like 11:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL11 Gene

No ASD Table

Relevant External Links for ARL11 Gene

GeneLoc Exon Structure for
ARL11
ECgene alternative splicing isoforms for
ARL11

Expression for ARL11 Gene

mRNA expression in normal human tissues for ARL11 Gene

mRNA differential expression in normal tissues according to GTEx for ARL11 Gene

This gene is overexpressed in Whole Blood (x31.0).

Protein differential expression in normal tissues from HIPED for ARL11 Gene

This gene is overexpressed in Monocytes (39.3) and Spleen (29.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL11 Gene



SOURCE GeneReport for Unigene cluster for ARL11 Gene Hs.558599

mRNA Expression by UniProt/SwissProt for ARL11 Gene

Q969Q4-ARL11_HUMAN
Tissue specificity: Expressed in lung and leukocytes.
genes like me logo Genes that share expression patterns with ARL11: view

Protein tissue co-expression partners for ARL11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ARL11 Gene

Orthologs for ARL11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARL11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARL11 35
  • 80.7 (n)
  • 76.84 (a)
ARL11 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl11 35
  • 83.9 (n)
  • 86.36 (a)
Arl11 16
Arl11 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARL11 35
  • 99.15 (n)
  • 98.98 (a)
ARL11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl11 35
  • 81.7 (n)
  • 84.97 (a)
oppossum
(Monodelphis domestica)
Mammalia ARL11 36
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARL11 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARL11 35
  • 61.88 (n)
  • 56.32 (a)
ARL11 36
  • 51 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490310 35
  • 60.54 (n)
  • 58.62 (a)
zebrafish
(Danio rerio)
Actinopterygii arl11 35
  • 56.7 (n)
  • 44.25 (a)
arl11 36
  • 43 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARF3 36
  • 38 (a)
OneToMany
Species with no ortholog for ARL11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARL11 Gene

ENSEMBL:
Gene Tree for ARL11 (if available)
TreeFam:
Gene Tree for ARL11 (if available)

Paralogs for ARL11 Gene

Paralogs for ARL11 Gene

(27) SIMAP similar genes for ARL11 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARL11: view

Variants for ARL11 Gene

Sequence variations from dbSNP and Humsavar for ARL11 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_023742 -
VAR_023743 -
VAR_023744 -
VAR_023745 -
VAR_048318 -

Structural Variations from Database of Genomic Variants (DGV) for ARL11 Gene

Variant ID Type Subtype PubMed ID
nsv900071 CNV Gain 21882294

Variation tolerance for ARL11 Gene

Residual Variation Intolerance Score: 86.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL11 Gene

HapMap Linkage Disequilibrium report
ARL11
Human Gene Mutation Database (HGMD)
ARL11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL11 Gene

Disorders for ARL11 Gene

MalaCards: The human disease database

(6) MalaCards diseases for ARL11 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
ovarian cystadenocarcinoma
  • cystadenocarcinoma of the ovary
dysplastic nevus syndrome
  • famm syndrome
chronic leukemia
ovary adenocarcinoma
  • ovarian adenocarcinoma
chronic lymphocytic leukemia
  • lymphoplasmacytic leukemia
- elite association
Search ARL11 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

ARL11_HUMAN
  • Leukemia, chronic lymphocytic (CLL) [MIM:151400]: A chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ARL11

Genetic Association Database (GAD)
ARL11
Human Genome Epidemiology (HuGE) Navigator
ARL11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL11
genes like me logo Genes that share disorders with ARL11: view

No data available for Genatlas for ARL11 Gene

Publications for ARL11 Gene

  1. [Effects of ARLTS1 gene on growth and apoptosis of epithelial ovarian cancer SKOV3 cells]. (PMID: 19292033) Yang X.Y. … Peng Z.L. (Sichuan Da Xue Xue Bao Yi Xue Ban 2009) 23 67
  2. ARLTS1 - a novel tumor suppressor gene. (PMID: 18375053) Yendamuri S. … Calin G.A. (Cancer Lett. 2008) 23 67
  3. Association of the ARLTS1 Cys148Arg variant with familial breast cancer risk. (PMID: 16353159) Frank B. … Burwinkel B. (Int. J. Cancer 2006) 23 67
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  5. A genome-wide association study of brain lesion distribution in multiple sclerosis. (PMID: 23412934) Gourraud P.A. … Baranzini S.E. (Brain 2013) 67

Products for ARL11 Gene

Sources for ARL11 Gene

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