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ARL11 Gene

protein-coding GIFtS: 59

GC13P049100

ADP-ribosylation factor-like 11
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
ARLTS1 ^¹, ², ³, ⁵
FLJ33930 ^¹, ²
MGC17429 ^²
OTTHUMP00000018420 ^²

Descriptions
ADP-ribosylation factor-like 11 ^²
ADP-ribosylation factor-like tumor suppressor protein 1 ^², ³

External Ids
HGNC: 24046¹
Entrez Gene: 115761²
UniProtKB: Q969Q4³
Ensembl: ENSG00000152213⁷

Search outside databases for aliases for ARL11 gene

Previous GC identifer: GC13P048000

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4

Function: May play a role in apoptosis. May act as a tumor suppressor

Gene Wiki entry for ARL11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ARL11 gene

Entrez Gene cytogenetic band: 13q14.3 Ensembl cytogenetic band: 13q14.3 HGNC cytogenetic band: 13q14.12

ARL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P049100: (about GC identifiers)

Start:	49,100,436 bp from pter
End:	49,106,009 bp from pter
Size:	5,574 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000013.9 NT_024524.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4 (See protein sequence)

Recommended Name: ADP-ribosylation factor-like protein 11

Size: 196 amino acids; 21391 Da

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_612459.1

ENSEMBL proteins:

ENSP00000282026

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ARL11)
	Human Recombinant Proteins from Abnova (ARL11)

OriGene Purified Recombinant Human Protein: ARL11

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

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Antibodies for ARL11:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (ARL11), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ARL11)
	Novus Biologicals Antibodies for ARL11

Assays for ARL11:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q969Q4

ProtoNet protein and cluster: Q969Q4

1 Blocks protein family: IPB006688 ADP-ribosylation factor

UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4

Similarity: Belongs to the small GTPase superfamily. Arf family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARL11)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138450

Applied Biosystems Silencer® siRNAs for ARL11

Sigma-Aldrich siRNA for ARL11

Sigma-Aldrich shRNA for ARL11

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ARL11
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_138450
Myc/DDK tagged cDNA clone in CMV expression vector: NM_138450
untagged cDNA clones in CMV expression vector (see all 2): BC013150

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: BC013150

UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4

Function: May play a role in apoptosis. May act as a tumor suppressor

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0005525	GTP binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for ARL11 (Q969Q4²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
TRIP13 Q15645² MINT-68304
About this table
1 Gene Ontology (GO) biological process term (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ARL11

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARL11)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138450

Sigma-Aldrich siRNA for ARL11

Sigma-Aldrich shRNA for ARL11

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_138450

REFSEQ mRNAs for ARL11 gene:

NM_138450.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_138450

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_138450
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_138450
                                 untagged cDNA clones in CMV expression vector (see all 2): BC013150

Additional cDNA sequence:

AF441378.1 AK091249.1 BC013150.1 CR600646.1

3 DOTS entries:

DT.95071791 DT.75184292 DT.440437

22 AceView cDNA sequences:

BM801294 AX746876 AK091249 BC013150 CR600646 BX337240 AF441378 BF797894

AI523278 BX106716 AA058535 NM_138450 BQ065118 AA759085 BM475738 BM146309

BG025694 BM148903 BI021680 BX337239 AI970339 AA057305

highest scoring ESTs for ARL11:

AA058535 AA759085 AF441378 AI970339 AK091249 BC013150 BF797894 BG025694 BM146309 BM148903

Unigene Cluster for ARL11:

ADP-ribosylation factor-like 11

Hs.558599 [show with all ESTs]

Unigene Representative Sequence: AF441378

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000282026

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

ARL11 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ARL11

¹ / ² / ³

3 probe-sets matching ARL11 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
57499_at²^{, 3}	U95-C	2	1.00	0.97	1.00	1.00	AI970339	0.80	1.00	0.91	1
1552693_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1552691_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks ARL11 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCGGAGGAG

SOURCE GeneReport for Unigene cluster: Hs.558599
UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4
Tissue specificity: Expressed in lung and leukocytes

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ARL11 gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	ARL11¹	--	ADP-ribosylation factor-like 11	99.15(n) 98.98(a)	467358 XM_522755.2 XP_522755.1
cow (Bos taurus)	ARL11¹	--	ADP-ribosylation factor-like 11	80.66(n) 76.8(a)	513113 XM_590750.3 XP_590750.3
rat (Rattus norvegicus)	Arl11¹	--	ADP-ribosylation factor-like 11	81.7(n) 84.97(a)	364396 NM_001013433.1 NP_001013451.1
mouse (Mus musculus)	Arl11^{1, 5}	14⁵	ADP-ribosylation factor-like 11^{1, 5}	83.9(n)¹ 86.36(a)¹	219144¹ NM_177337.3¹ NP_796311.2¹ AK008804⁵ AK050053⁵ (see all 7)
chicken (Gallus gallus)	ARL11¹	--	ADP-ribosylation factor-like 11	61.88(n) 56.32(a)	418869 XM_417064.2 XP_417064.1

About this table Species with no ortholog for ARL11

ENSEMBL Gene Tree for ARL11

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for ARL11 gene

ARL14² ARL4D² ARL4P² ARL4A² ARL4C²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/27 NCBI SNPs in ARL11 are shown (see all 27 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 25)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs9535277^1,2	A,C,F,H	49105134(+)	`caagcA/Gctgtg`	1	--	ut3¹		4		EU EA WA	412
	rs9526582^1,2	C,F,H	49105221(+)	`CAAACT/GGAGGC`	1	--	ut3¹ ese³		4		EU EA WA	410
	rs1535467^1,2	A,C,F	49104329(+)	`CTTTCC/GTTAAA`	1	--	ut3¹		1		MN	184
--	rs3803185^1,2	C,F,H	49103026(-)	`CCAGCA/GGTGGT`	1	C/R	mis¹ ese³		9		EU EA WA NA	914
	rs35712316^1,2	C,F	49102942(+)	`TGGTGC/ATGGCC`	1	M/L	mis¹		5		NA EU EA WA	494
--	rs12872641^1,2	A	49099932(+)	`gttagC/Tcaggc`	1	--	ng5¹		0	--	--	--	--
--	rs12872526^1,2	A	49099930(+)	`atgttA/Ggccag`	1	--	ng5¹		0	--	--	--	--
	rs3803186^1,2	C,F	49102881(-)	`GCCGCC/TGACTC`	1	S/S	syn¹ ese³		2		EA NA	1574
	rs7986690^1,2	C,F,H	49102332(+)	`GAAAAG/ACTCTT`	1	--	int¹		3		EU EA	300
	rs9316470^1,2	C,F,H	49101764(+)	`gtaccG/Agtgtg`	1	--	int¹		12		EU EA WA	1252

About this table

HapMap Linkage Disequilibrium images for ARL11 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609351

UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4

Defects in ARL11 may be a cause of susceptibility to chronic lymphocytic leukemia (CLL)

[MIM:151400]

Human Gene Mutation Database: ARL11
Genetic Association Database: ARL11
Human Genome Epidemiology Navigator: ARL11 (9 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/18 PubMed articles for ARL11 gene (see all 18 ):

Familial cancer associated with a polymorphism in ARLTS1. (PubMed id 15843669)^{3, 4, 6} Calin G.A.... Croce C.M. (2005)
Association of the ARLTS1 Cys148Arg variant with familial breast cancer risk. (PubMed id 16353159)^{1, 3, 6} Frank B....Burwinkel B. (2006)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{3, 4} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer. (PubMed id 18337727)³ Siltanen S....Vahteristo P. (2008)
Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)⁴ Imami K.... Ishihama Y. (2008)
Association of the ARLTS1 Cys148Arg variant with sporadic and familial colorectal cancer. (PubMed id 17449901)³ Castellvi-Bel S....Pique J.M. (2007)
No association of ARLTS1 polymorphisms and risk for familial chronic lymphocytic leukaemia. (PubMed id 17391501)³ Ng D....Toro J.R. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 115761	HGNC: 24046	AceView: ARL11	Ensembl:ENSG00000152213	euGenes: HUgn115761
ECgene: ARL11	H-InvDB: ARL11

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ARL11	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ARL11
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ARL11:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ARL11-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ARL11		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ARL11		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Purified proteins from HEK293T cells
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	shRNA in GFP-retroviral vector

Search Tocris compounds for ARL11

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ARL11 Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for ARL11

Summaries
for ARL11

Genomic Location
for ARL11

Proteins
for ARL11

Protein Domains/
Families
for ARL11

Gene Function
for ARL11

Pathways & Interactions
for ARL11

Drugs & Compounds
for ARL11

Transcripts
for ARL11

Expression
for ARL11

Orthologs
for ARL11

Paralogs
for ARL11

SNPs/Variants
for ARL11

Disorders & Mutations
for ARL11

Medical News
for ARL11

Publications
for ARL11

Search for ARL11

Genome Databases showing ARL11

Other Databases showing ARL11

Specialized Databases showing ARL11

Licensable Technologies
for ARL11

Services
for ARL11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ARL11 Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor ARL11

Summariesfor ARL11

Genomic Locationfor ARL11

Proteinsfor ARL11

Protein Domains/Familiesfor ARL11

Gene Functionfor ARL11

Pathways & Interactionsfor ARL11

Drugs & Compoundsfor ARL11

Transcriptsfor ARL11

Expression for ARL11

Orthologsfor ARL11

Paralogsfor ARL11

SNPs/Variantsfor ARL11

Disorders & Mutationsfor ARL11

Medical Newsfor ARL11

Publicationsfor ARL11

Search for ARL11

Genome Databases showing ARL11

Other Databases showing ARL11

Specialized Databases showing ARL11

Licensable Technologiesfor ARL11

Servicesfor ARL11

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ARL11

Summaries
for ARL11

Genomic Location
for ARL11

Proteins
for ARL11

Protein Domains/
Families
for ARL11

Gene Function
for ARL11

Pathways & Interactions
for ARL11

Drugs & Compounds
for ARL11

Transcripts
for ARL11

Expression
for ARL11

Orthologs
for ARL11

Paralogs
for ARL11

SNPs/Variants
for ARL11

Disorders & Mutations
for ARL11

Medical News
for ARL11

Publications
for ARL11

Licensable Technologies
for ARL11

Services
for ARL11