ARL11 Gene
protein-coding GIFtS: 54
GCID: GC13P050202
|
|
ADP-ribosylation factor-like 11
| |
Aliases
for ARL11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ADP-Ribosylation Factor-Like 111 2 | | ARLTS11 2 3 5 | | ADP-Ribosylation Factor-Like Tumor Suppressor Protein 12 3 | | FLJ339301 | | ADP-Ribosylation Factor-Like Protein 112 |
Export aliases for ARL11 gene to outside databasesPrevious GC identifers: GC13P048000 GC13P049100 GC13P030995 |
Summaries
for ARL11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARL11:
This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encodedprotein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been associatedwith some familial cancers. (provided by RefSeq, May 2010)
UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4Function: May play a role in apoptosis. May act as a tumor suppressor
Gene Wiki entry for ARL11
|
Genomic Views
for ARL11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_024524.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARL11 gene promoter:
GR NF-1 AML1a GR-beta Pax-2 Lmo2 Pax-2a Max GR-alpha c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARL11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q14.2 Ensembl cytogenetic band: 13q14.2 HGNC cytogenetic band: 13q14.12ARL11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P050202: view genomic region
(about GC identifiers)
Start:
|
50,202,435 bp from pter |
End:
|
50,208,008 bp from pter |
Size:
|
5,574 bases |
Orientation:
|
plus strand |
|
Proteins
for ARL11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4 (See
protein sequence)Recommended Name: ADP-ribosylation factor-like protein 11 Size: 196 amino acids; 21391 DaExplore the universe of human proteins at neXtProt for ARL11: NX_Q969Q4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q969Q4
ARL11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612459.1
ENSEMBL proteins: ENSP00000282026
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
ARL11 for ontologies About GeneDecksing
ARL11 Antibody Products:
Assay Products for ARL11: |
Protein
Domains /
Families
for ARL11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARL11 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q969Q4ProtoNet protein and cluster: Q969Q4 1 Blocks protein family: IPB006688 ADP-ribosylation factor
UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4Similarity: Belongs to the small GTPase superfamily. Arf family |
Function
for ARL11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4Function: May play a role in apoptosis. May act as a tumor suppressor
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARL11 (NM_138450) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARL11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL11 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
ARL11 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ARL11:
|
Pathways & Interactions
for ARL11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARL11
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for ARL11 (Q969Q41, 2, 3 ENSP000002820264) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007264 | small GTPase mediated signal transduction |
IEA | -- |
ARL11 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARL11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARL11
Search CenterWatch for drugs/clinical trials and news about ARL11
|
Transcripts
for ARL11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARL11 gene: NM_138450.5 Unigene Cluster for ARL11: ADP-ribosylation factor-like 11 Hs.558599 [show with all ESTs]Unigene Representative Sequence: AF4413782 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000282026(uc001vdf.2) ENST00000490932
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL11 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL11 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARL11 (NM_138450) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARL11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL11 |
Additional cDNA sequence: AF441378.1 AK091249.1 BC013150.1 3 DOTS entries: DT.95071791 DT.75184292 DT.440437 22 AceView cDNA sequences: BC013150 CR600646 AX746876 BM801294 AK091249 BX337240 NM_138450 AI523278 BQ065118 AF441378 AA058535 BF797894 BX106716 BM146309 BM475738 BG025694 AA759085 BM148903 BX337239 BI021680 AI970339 AA057305
GeneLoc Exon Structure
|
Expression
for ARL11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARL11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCGGAGGAG
About this image
See ARL11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARL11
SOURCE GeneReport for Unigene cluster: Hs.558599
UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4Tissue specificity: Expressed in lung and leukocytes
SABiosciences Custom PCR Arrays for ARL11
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARL11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL11 |
Orthologs
for ARL11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for ARL11 gene from 2/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ARL111 |
ADP-ribosylation factor-like 11 |
61.88(n)
56.32(a) |
|
418869 XM_417064.3 XP_417064.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
arl111 |
ADP-ribosylation factor-like 11 |
56.7(n)
44.25(a) |
|
324689 NM_199693.1 NP_955987.1 |
ENSEMBL Gene Tree for ARL11 (if available)
TreeFam Gene Tree for ARL11 (if available) |
Paralogs
for ARL11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARL11 gene
- ARL4A2 ARF42 ARF52 ARF12 ARL142 ARL4D2 ARF32 ARF62
- ARL92 ARL17B2 ARL4C2 TRIM232 ARL102
18/27 SIMAP similar genes for ARL11 using alignment to 1 protein entry: ARL11_HUMAN(see all similar genes):ARL3 ARF3 ARF5 ARL14 ARF1 ARL5A
TRIM23 ARF4 ARF6 ARL4A ARL4C ARL8B
SARA1 ARL6 ARL5B ARL7 ARL8A ARL1
ARL11 for paralogs About GeneDecksing
|
Genomic Variants
for ARL11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARL11 (50202435 - 50208008 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARL11: --
Human Gene Mutation Database (HGMD): ARL11
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL11 |
|
Disorders
/ Diseases
for ARL11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARL11 for disorders About GeneDecksing
OMIM gene information: 609351
OMIM disorders: --
UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4
Defects in ARL11 may be a cause of susceptibility to chronic lymphocytic leukemia (CLL) [MIM:151400]
13  diseases for ARL11: About MalaCardschronic lymphocytic leukemia epithelial ovarian cancer lymphocytic leukemia familial colorectal cancer
familial breast cancer ovarian cancer colorectal cancer breast cancer
leukemia melanoma lung cancer malaria
prostatitis
1 disease from the University of Copenhagen DISEASES database for ARL11:Dysplastic nevus syndrome Genetic Association Database (GAD): ARL11
Human Genome Epidemiology (HuGE) Navigator: ARL11 (12 documents)
Export disorders for ARL11 gene to outside databases
|
Publications
for ARL11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARL11 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with ARL11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Familial cancer associated with a polymorphism in ARLTS1. (PubMed id 15843669)1, 2, 4 Calin G.A.... Croce C.M. (2005)
- Association of the ARLTS1 Cys148Arg variant with familial breast cancer risk. (PubMed id 16353159)1, 4, 9 Frank B....Burwinkel B. (2006)
- The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2 Dunham A.... Ross M.T. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- ARLTS1 - a novel tumor suppressor gene. (PubMed id 18375053)1, 9 Yendamuri S....Calin G.A. (2008)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Contribution of ARLTS1 Cys148Arg (T442C) variant with prostate cancer risk and ARLTS1 function in prostate cancer cells. (PubMed id 22028916)1 Siltanen S....Schleutker J. (2011)
- ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer. (PubMed id 20358297)1 Akisik E....Dalay N. (2010)
|
External Searches for ARL11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARL11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARL11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARL11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for ARL11 gene:
Search GeneIP for patents involving ARL11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARL11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for ARL11 | | OriGene shRNA RFP for ARL11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL11 | | | OriGene Protein Over-expression Lysate for ARL11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARL11 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ARL11 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARL11 | | OriGene Custom Protein Services for ARL11 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARL11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL11 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for ARL11 |
| |  |  |  |  | | | | | | Recombinant Protein for ARL11 |
|
 |
 |
 |
 | | | ARL11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL11 |
|  |  |  | | | | Search ThermoFisher Antibodies for ARL11 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL11 |
|
|
|
|
