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ARL11 Gene

protein-coding   GIFtS: 55
GCID: GC13P050202

ADP-Ribosylation Factor-Like 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 111 2
ARLTS12 3 5
ADP-Ribosylation Factor-Like Tumor Suppressor Protein 12 3
ADP-Ribosylation Factor-Like Protein 112

External Ids:    HGNC: 240461   Entrez Gene: 1157612   Ensembl: ENSG000001522137   OMIM: 6093515   UniProtKB: Q969Q43   

Export aliases for ARL11 gene to outside databases

Previous GC identifers: GC13P048000 GC13P049100 GC13P030995


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARL11 Gene:
This gene encodes a tumor suppressor related to the ADP-ribosylation factor (ARF) family of proteins. The encoded
protein may play a role in apoptosis in a caspase-dependent manner. Polymorphisms in this gene have been
associated with some familial cancers. (provided by RefSeq, May 2010)

GeneCards Summary for ARL11 Gene:
ARL11 (ADP-ribosylation factor-like 11) is a protein-coding gene. Diseases associated with ARL11 include familial colorectal cancer, and dysplastic nevus syndrome. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL4D.

UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4
Function: May play a role in apoptosis. May act as a tumor suppressor

Gene Wiki entry for ARL11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000013.11  NT_024524.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL11 gene promoter:
         GR   NF-1   AML1a   GR-beta   Pax-2   Lmo2   Pax-2a   Max   GR-alpha   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARL11 promoter sequence
   Search Chromatin IP Primers for ARL11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q14.2   Ensembl cytogenetic band:  13q14.2   HGNC cytogenetic band: 13q14.12

ARL11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL11 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P050202:  view genomic region     (about GC identifiers)

Start:
50,202,435 bp from pter      End:
50,208,008 bp from pter
Size:
5,574 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 11  
Size: 196 amino acids; 21391 Da

Explore the universe of human proteins at neXtProt for ARL11: NX_Q969Q4

Explore proteomics data for ARL11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARL11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612459.1  
    ENSEMBL proteins: 
     ENSP00000282026  

    ARL11 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry Q969Q4

    ProtoNet protein and cluster: Q969Q4

    1 Blocks protein domain: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL11_HUMAN, Q969Q4
    Function: May play a role in apoptosis. May act as a tumor suppressor

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0005525GTP binding IEA--
         
    ARL11 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARL11:
     Increased G2M DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL11
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    miRNA
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    Block miRNA regulation of human, mouse, rat ARL11 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL11 (see all 9):
    hsa-miR-3163 hsa-miR-3678-3p hsa-miR-4311 hsa-miR-513c hsa-miR-2115 hsa-miR-3622b-3p hsa-miR-1252 hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidARL11 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARL11

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    cytoskeleton2
    mitochondrion2
    endoplasmic reticulum1
    extracellular1
    peroxisome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--
    GO:0005634nucleus ----
    GO:0005737cytoplasm ----

    ARL11 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL11
    Interactions:

        Search GeneGlobe Interaction Network for ARL11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for ARL11 (Q969Q41, 2, 3 ENSP000002820264) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIP13Q156451, 2, 3, ENSP000001663454EBI-751892,EBI-358993 MINT-68304 I2D: score=4 STRING: ENSP00000166345
    PIGTENSP000002790364STRING: ENSP00000279036
    POLR3EENSP000002998534STRING: ENSP00000299853
    STX16ENSP000003601834STRING: ENSP00000360183
    GBF1ENSP000003590004STRING: ENSP00000359000
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006886intracellular protein transport ----
    GO:0007264small GTPase mediated signal transduction IEA--

    ARL11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL11



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARL11 gene: 
    NM_138450.5  

    Unigene Cluster for ARL11:

    ADP-ribosylation factor-like 11
    Hs.558599  [show with all ESTs]
    Unigene Representative Sequence: AF441378
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000282026(uc001vdf.2) ENST00000490932
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARL11 (see all 9):
    hsa-miR-3163 hsa-miR-3678-3p hsa-miR-4311 hsa-miR-513c hsa-miR-2115 hsa-miR-3622b-3p hsa-miR-1252 hsa-miR-514b-5p
    SwitchGear 3'UTR luciferase reporter plasmidARL11 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AF441378.1 AK091249.1 BC013150.1 

    3 DOTS entries:

    DT.95071791  DT.75184292  DT.440437 

    22 AceView cDNA sequences:

    BC013150 AK091249 BM801294 AX746876 CR600646 AI523278 AA058535 AF441378 
    BF797894 BQ065118 BX106716 BX337240 NM_138450 BM146309 AA759085 BG025694 
    BM475738 BM148903 BI021680 BX337239 AI970339 AA057305 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGGAGGAG
    ARL11 Expression
    About this image

    ARL11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.558599

    UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4
    Tissue specificity: Expressed in lung and leukocytes

        Custom PCR Arrays for ARL11
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARL11 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl111 , 5 ADP-ribosylation factor-like 111, 5 83.9(n)1
    86.36(a)1
      14 (32.66 cM)5
    2191441  NM_177337.31  NP_796311.21 
     613097535 
    chicken
    (Gallus gallus)
    Aves ARL111 ADP-ribosylation factor-like 11 61.88(n)
    56.32(a)
      418869  XM_004938719.1  XP_004938776.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004903101 ADP-ribosylation factor-like protein 11-like 60.54(n)
    58.62(a)
      100490310  XM_002935735.2  XP_002935781.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arl111 ADP-ribosylation factor-like 11 56.7(n)
    44.25(a)
      324689  NM_199693.1  NP_955987.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARF36
    Glucose-repressible ADP-ribosylation factor, GTPas...
    38(a)
    1 → many
    XV(502795-503346) YOR094W


    ENSEMBL Gene Tree for ARL11 (if available)
    TreeFam Gene Tree for ARL11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL11 gene
    ARL4D2  ARL142  ARL4A2  ARL4C2  
    Selected SIMAP similar genes for ARL11 using alignment to 1 protein entry:     ARL11_HUMAN(see all similar genes):
    ARL3    ARF3    ARF5    ARL14    ARF1    ARL2
    ARL5A    TRIM23    ARF4    ARF6    ARL4A    ARL4C
    ARL8B    SARA1    ARL6    ARL5B    ARL7    ARL8A

    ARL11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL11 (see all 174)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs343013441,2
    C,Funtested131149616(+) CTGCTG/AGGAGC 2 /* /W stg14Minor allele frequency- A:0.01NA EU 4709
    rs2000014031,2
    C--30994393(+) TTTTC-/TTTTTT 1 -- us2k10--------
    rs2007732761,2
    C--30995362(+) GCTAA-/TTTTTG 1 -- us2k10--------
    rs1433755321,2
    --31145050(+) CTGCTG/TCTTTT 1 -- us2k10--------
    rs574130931,2
    --31145100(+) TGGAGC/TGCAGT 1 -- us2k10--------
    rs1879346511,2
    --31145105(+) TGCAGC/TGGCGC 1 -- us2k10--------
    rs1930017831,2
    --31145109(+) GTGGCA/GCGATC 1 -- us2k10--------
    rs1467392911,2
    --31145286(+) TGTGAC/TCTGCC 1 -- us2k10--------
    rs1850707951,2
    --31145732(+) AATTGC/TTTGAA 1 -- us2k10--------
    rs1892059181,2
    --31145746(+) AGGAGA/GCGGAG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARL11 (50202435 - 50208008 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for ARL11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv900071CNV Gain21882294

    Human Gene Mutation Database (HGMD): ARL11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL11
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609351    OMIM disorders: --

    UniProtKB/Swiss-Prot: ARL11_HUMAN, Q969Q4
  • Leukemia, chronic lymphocytic (CLL) [MIM:151400]: A chronic leukemia in which functionally incompetent
    B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of
    the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease
    and short survival. Note=Disease susceptibility is associated with variations affecting the gene represented in
    this entry

  • 16 diseases for ARL11:    
    About MalaCards
    familial colorectal cancer    dysplastic nevus syndrome    familial breast cancer    b-cell chronic lymphocytic leukemia
    colorectal cancer    chronic lymphocytic leukemia    ovarian cancer    lung cancer
    breast cancer    multiple myeloma    multiple sclerosis    myeloma
    prostate cancer    melanoma    prostatitis    leukemia

    1 disease from the University of Copenhagen DISEASES database for ARL11:
    Dysplastic nevus syndrome

    ARL11 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARL11
    Human Genome Epidemiology (HuGE) Navigator: ARL11 (12 documents)

    Export disorders for ARL11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL11 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with ARL11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Familial cancer associated with a polymorphism in ARLTS1. (PubMed id 15843669)1, 2, 4 Calin G.A.... Croce C.M. (N. Engl. J. Med. 2005)
    2. Association of the ARLTS1 Cys148Arg variant with familial breast cancer risk. (PubMed id 16353159)1, 4, 9 Frank B....Burwinkel B. (Int. J. Cancer 2006)
    3. ARLTS1, MDM2 and RAD51 gene variations are associated with familial breast cancer. (PubMed id 20358297)1, 4 Akisik E....Dalay N. (Mol. Biol. Rep. 2011)
    4. Association of the ARLTS1 variants with familial ovarian cancer risk in China. (PubMed id 19509554)1, 4 Yang X.Y....Peng Z.L. (Int. J. Gynecol. Cancer 2009)
    5. ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer. (PubMed id 18337727)1, 4 Siltanen S....Vahteristo P. (Eur. J. Hum. Genet. 2008)
    6. Association of the ARLTS1 Cys148Arg variant with sporadic and familial colorectal cancer. (PubMed id 17449901)1, 4 CastellvA--Bel S....PiquAc J.M. (Carcinogenesis 2007)
    7. No association of ARLTS1 polymorphisms and risk for familial chronic lymphocytic leukaemia. (PubMed id 17391501)1, 4 Ng D....Toro J.R. (Br. J. Haematol. 2007)
    8. Relationship between ARLTS1 polymorphisms and risk of chronic lymphocytic leukemia. (PubMed id 16581122)1, 4 Sellick G.S....Houlston R.S. (Leuk. Res. 2006)
    9. Cancer Familial Aggregation (CFA) and G446A polymorphism in ARLTS1 gene. (PubMed id 16570116)1, 4 MasojA8 B....LubiA8ski J. (Breast Cancer Res. Treat. 2006)
    10. ARLTS1 variants and risk of colorectal cancer. (PubMed id 16488076)1, 4 Frank B....Burwinkel B. (Cancer Lett. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115761 HGNC: 24046 AceView: ARL11 Ensembl:ENSG00000152213 euGenes: HUgn115761
    ECgene: ARL11 H-InvDB: ARL11

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARL11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARL11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARL11 gene:
    Search GeneIP for patents involving ARL11

    GeneCards and IP:
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