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Aliases for ARL10 Gene

Aliases for ARL10 Gene

  • ADP Ribosylation Factor Like GTPase 10 2 3 5
  • ADP-Ribosylation Factor-Like 10A 2 3
  • ARL10A 3 4
  • ADP-Ribosylation Factor-Like Membrane-Associated Protein 3
  • ADP-Ribosylation Factor-Like Protein 10 3
  • ADP-Ribosylation Factor Like GTPase 10 2

External Ids for ARL10 Gene

Previous HGNC Symbols for ARL10 Gene

  • ARL10A

Previous GeneCards Identifiers for ARL10 Gene

  • GC05P175726
  • GC05P175792
  • GC05P170718

Summaries for ARL10 Gene

GeneCards Summary for ARL10 Gene

ARL10 (ADP Ribosylation Factor Like GTPase 10) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL1.

Additional gene information for ARL10 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL10 Gene

Genomics for ARL10 Gene

Regulatory Elements for ARL10 Gene

Enhancers for ARL10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H176410 1.6 Ensembl ENCODE dbSUPER 15.7 +49.4 49449 8.8 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 FOS SP5 ENSG00000251414 FAF2 HIGD2A ARL10 NOP16 UIMC1 ENSG00000250909 MIR1271 KIAA1191 CDHR2
GH05H176552 1.3 Ensembl ENCODE dbSUPER 10.3 +188.3 188341 3.5 BCOR SIN3A ZMYM3 BMI1 BATF ZIC2 ZKSCAN1 GLIS2 POLR2A FOSL2 FAF2 ENSG00000250909 NSD1 ENSG00000251414 ARL10 MIR1271 KIAA1191 UNC5A CDHR2 GC05M176548
GH05H176340 0.8 ENCODE 11.6 -23.5 -23506 2.6 PKNOX1 FOXA2 NFIB RARA TCF12 ZNF121 GATA2 ATF7 ZEB2 NFIL3 KIAA1191 ARL10 MIR1271 SIMC1 FAM153B ENSG00000250909 BRCC3P1
GH05H176423 0.8 ENCODE dbSUPER 10.8 +60.6 60572 5.6 GLIS1 ZSCAN29 ELF1 SETDB1 FAF2 CDHR2 RN7SL684P MIR1271 KIAA1191 ARL10 GPRIN1 ENSG00000251414 HIGD2A CLTB
GH05H176481 0.7 ENCODE 9.6 +116.5 116463 0.8 HDAC1 KLF1 SAP130 BACH1 ZNF316 NFE2 MAFK NFE2L2 L3MBTL2 MAFG CLTB FAF2 NOP16 HIGD2A CDHR2 RN7SL684P MIR1271 KIAA1191 ARL10 PIR40188
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL10 on UCSC Golden Path with GeneCards custom track

Promoters for ARL10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000191209 232 1001 RING1 LEF1 MXI1 KLF1 SUZ12 BACH1 ZFHX2 GLIS2 POLR2A ZNF143

Genomic Locations for ARL10 Gene

Genomic Locations for ARL10 Gene
chr5:176,365,468-176,415,463
(GRCh38/hg38)
Size:
49,996 bases
Orientation:
Plus strand
chr5:175,792,471-175,828,866
(GRCh37/hg19)

Genomic View for ARL10 Gene

Genes around ARL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL10 Gene

Proteins for ARL10 Gene

  • Protein details for ARL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8L6-ARL10_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 10
    Protein Accession:
    Q8N8L6

    Protein attributes for ARL10 Gene

    Size:
    244 amino acids
    Molecular mass:
    27459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL10 Gene

Post-translational modifications for ARL10 Gene

  • Ubiquitination at Lys100
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL10 Gene

No data available for DME Specific Peptides for ARL10 Gene

Domains & Families for ARL10 Gene

Gene Families for ARL10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for ARL10 Gene

Suggested Antigen Peptide Sequences for ARL10 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N8L6

UniProtKB/Swiss-Prot:

ARL10_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL10: view

Function for ARL10 Gene

Gene Ontology (GO) - Molecular Function for ARL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL10: view
genes like me logo Genes that share phenotypes with ARL10: view

Animal Models for ARL10 Gene

MGI Knock Outs for ARL10:

miRNA for ARL10 Gene

miRTarBase miRNAs that target ARL10

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL10 Gene

Localization for ARL10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL10 gene
Compartment Confidence
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ARL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARL10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for ARL10 Gene

Pathways & Interactions for ARL10 Gene

SuperPathways for ARL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL10: view

No data available for Pathways by source and SIGNOR curated interactions for ARL10 Gene

Drugs & Compounds for ARL10 Gene

No Compound Related Data Available

Transcripts for ARL10 Gene

Unigene Clusters for ARL10 Gene

ADP-ribosylation factor-like 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL10 Gene

No ASD Table

Relevant External Links for ARL10 Gene

GeneLoc Exon Structure for
ARL10
ECgene alternative splicing isoforms for
ARL10

Expression for ARL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARL10 Gene

Protein differential expression in normal tissues from HIPED for ARL10 Gene

This gene is overexpressed in Fetal Brain (45.7), Islet of Langerhans (13.9), and Frontal cortex (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL10 Gene



Protein tissue co-expression partners for ARL10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL10 Gene:

ARL10

SOURCE GeneReport for Unigene cluster for ARL10 Gene:

Hs.424552

Evidence on tissue expression from TISSUES for ARL10 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with ARL10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARL10 Gene

Orthologs for ARL10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL10 33 34
  • 98.36 (n)
dog
(Canis familiaris)
Mammalia ARL10 34 33
  • 91.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arl10 33
  • 86.51 (n)
mouse
(Mus musculus)
Mammalia Arl10 34 16 33
  • 85.73 (n)
OneToOne
cow
(Bos Taurus)
Mammalia ARL10 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL10 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 28 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ARL10 34 33
  • 64.18 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL10 34
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl10 33
  • 51.91 (n)
zebrafish
(Danio rerio)
Actinopterygii arl10 34 33
  • 55.02 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Gie 34
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arl-8 34
  • 33 (a)
OneToMany
Species where no ortholog for ARL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL10 Gene

ENSEMBL:
Gene Tree for ARL10 (if available)
TreeFam:
Gene Tree for ARL10 (if available)

Paralogs for ARL10 Gene

Paralogs for ARL10 Gene

(19) SIMAP similar genes for ARL10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARL10: view

Variants for ARL10 Gene

Sequence variations from dbSNP and Humsavar for ARL10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000027940 -- 176,400,004(+) CTGAC(C/T)AACAT intron-variant
rs1000043248 -- 176,391,571(+) TGCAC(C/G)ACTGC intron-variant
rs1000108407 -- 176,384,619(+) CTGTC(G/T)CTCCA intron-variant
rs1000162708 -- 176,405,779(+) ACTCG(C/T)GACCT intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000189102 -- 176,365,469(+) GGGTG(A/G)GTGGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for ARL10 Gene

Variant ID Type Subtype PubMed ID
nsv600341 CNV gain 21841781
nsv462549 CNV gain 19166990
nsv1023853 CNV gain 25217958
esv2731168 CNV deletion 23290073
esv2731167 CNV deletion 23290073

Variation tolerance for ARL10 Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL10 Gene

Disorders for ARL10 Gene

Relevant External Links for ARL10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL10

No disorders were found for ARL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL10 Gene

Publications for ARL10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. RASL11A, member of a novel small monomeric GTPase gene family, is down-regulated in prostate tumors. (PMID: 15033445) Louro R … Reis EM (Biochemical and biophysical research communications 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for ARL10 Gene

Sources for ARL10 Gene

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