Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARL10 Gene

Aliases for ARL10 Gene

  • ADP Ribosylation Factor Like GTPase 10 2 3 5
  • ADP-Ribosylation Factor-Like 10A 2 3
  • ARL10A 3 4
  • ADP-Ribosylation Factor-Like Membrane-Associated Protein 3
  • ADP-Ribosylation Factor-Like Protein 10 3
  • ADP-Ribosylation Factor Like GTPase 10 2

External Ids for ARL10 Gene

Previous HGNC Symbols for ARL10 Gene

  • ARL10A

Previous GeneCards Identifiers for ARL10 Gene

  • GC05P175726
  • GC05P175792
  • GC05P170718

Summaries for ARL10 Gene

GeneCards Summary for ARL10 Gene

ARL10 (ADP Ribosylation Factor Like GTPase 10) is a Protein Coding gene. GO annotations related to this gene include GTP binding. An important paralog of this gene is ARL11.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL10 Gene

Genomics for ARL10 Gene

Regulatory Elements for ARL10 Gene

Enhancers for ARL10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F176410 1.3 Ensembl ENCODE 15.7 +49.4 49449 8.8 PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 FOS KLF13 ENSG00000251414 FAF2 HIGD2A ARL10 NOP16 ENSG00000250909 MIR1271 KIAA1191 CDHR2 RN7SL684P
GH05F176423 1 ENCODE 10.8 +60.6 60572 5.6 ATF1 MLX ARID4B SIN3A ZNF48 YY1 MXD4 ZHX2 MIER2 PPARG FAF2 CDHR2 RN7SL684P MIR1271 ARL10 KIAA1191 GPRIN1 ENSG00000251414 HIGD2A CLTB
GH05F176552 1 Ensembl ENCODE 10.3 +188.4 188371 3.5 BCOR ZMYM3 ZIC2 GLIS2 POLR2A FOSL2 FOS MAFK ZBTB20 ZNF263 FAF2 KIAA1191 ARL10 MIR1271 UNC5A CDHR2 GC05M176548 GC05P176557
GH05F176340 0.8 ENCODE 11.6 -23.5 -23506 2.6 PKNOX1 ESRRA ZNF146 SAP130 TAL1 ZNF644 RARA ZNF121 ZNF664 NCOR1 KIAA1191 ARL10 MIR1271 SIMC1 FAM153B ENSG00000250909 BRCC3P1
GH05F176596 0.9 Ensembl ENCODE 9.6 +231.7 231718 2.3 CTCF ZFP64 ZBTB11 ZNF140 ZBTB8A ZNF623 RAD21 ZNF518A ZNF781 ZNF101 FAF2 EIF4E1B ENSG00000250909 ZNF346-IT1 ZNF346 SNCB ENSG00000251414 TSPAN17 RN7SL684P CDHR2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL10 on UCSC Golden Path with GeneCards custom track

Promoters for ARL10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001297571 133 1600 RING1 KLF1 SUZ12 SIN3A ZFHX2 GLIS2 EGR1 POLR2A ZNF143 CREM

Genomic Location for ARL10 Gene

Chromosome:
5
Start:
176,365,468 bp from pter
End:
176,415,463 bp from pter
Size:
49,996 bases
Orientation:
Plus strand

Genomic View for ARL10 Gene

Genes around ARL10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL10 Gene

Proteins for ARL10 Gene

  • Protein details for ARL10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8L6-ARL10_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 10
    Protein Accession:
    Q8N8L6

    Protein attributes for ARL10 Gene

    Size:
    244 amino acids
    Molecular mass:
    27459 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARL10 Gene

Post-translational modifications for ARL10 Gene

  • Ubiquitination at Lys 100
  • Modification sites at PhosphoSitePlus

Other Protein References for ARL10 Gene

No data available for DME Specific Peptides for ARL10 Gene

Domains & Families for ARL10 Gene

Gene Families for ARL10 Gene

Protein Domains for ARL10 Gene

Suggested Antigen Peptide Sequences for ARL10 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N8L6

UniProtKB/Swiss-Prot:

ARL10_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL10: view

Function for ARL10 Gene

Gene Ontology (GO) - Molecular Function for ARL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with ARL10: view
genes like me logo Genes that share phenotypes with ARL10: view

Animal Models for ARL10 Gene

MGI Knock Outs for ARL10:

Animal Model Products

  • Taconic Biosciences Mouse Models for ARL10

miRNA for ARL10 Gene

miRTarBase miRNAs that target ARL10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARL10 Gene

Localization for ARL10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL10 gene
Compartment Confidence
extracellular 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for ARL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with ARL10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARL10 Gene

Pathways & Interactions for ARL10 Gene

SuperPathways for ARL10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL10: view

No data available for Pathways by source and SIGNOR curated interactions for ARL10 Gene

Transcripts for ARL10 Gene

Unigene Clusters for ARL10 Gene

ADP-ribosylation factor-like 10:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL10 Gene

No ASD Table

Relevant External Links for ARL10 Gene

GeneLoc Exon Structure for
ARL10
ECgene alternative splicing isoforms for
ARL10

Expression for ARL10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL10 Gene

Protein differential expression in normal tissues from HIPED for ARL10 Gene

This gene is overexpressed in Fetal Brain (45.7), Islet of Langerhans (13.9), and Frontal cortex (9.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARL10 Gene



Protein tissue co-expression partners for ARL10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL10 Gene:

ARL10

SOURCE GeneReport for Unigene cluster for ARL10 Gene:

Hs.424552
genes like me logo Genes that share expression patterns with ARL10: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARL10 Gene

Orthologs for ARL10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARL10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL10 34 35
  • 98.36 (n)
dog
(Canis familiaris)
Mammalia ARL10 34 35
  • 91.27 (n)
rat
(Rattus norvegicus)
Mammalia Arl10 34
  • 86.51 (n)
mouse
(Mus musculus)
Mammalia Arl10 34 16 35
  • 85.73 (n)
cow
(Bos Taurus)
Mammalia ARL10 35
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL10 35
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 28 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ARL10 34 35
  • 64.18 (n)
lizard
(Anolis carolinensis)
Reptilia ARL10 35
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl10 34
  • 51.91 (n)
zebrafish
(Danio rerio)
Actinopterygii arl10 34 35
  • 55.02 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gie 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea arl-8 35
  • 33 (a)
OneToMany
Species where no ortholog for ARL10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL10 Gene

ENSEMBL:
Gene Tree for ARL10 (if available)
TreeFam:
Gene Tree for ARL10 (if available)

Paralogs for ARL10 Gene

Paralogs for ARL10 Gene

(19) SIMAP similar genes for ARL10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARL10: view

Variants for ARL10 Gene

Sequence variations from dbSNP and Humsavar for ARL10 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10042045 -- 176,385,214(+) TGAGC(C/T)GCTCA intron-variant
rs10214381 -- 176,371,942(+) GTTGT(A/C)CTGCT intron-variant, utr-variant-3-prime
rs1044371 -- 176,380,346(+) CTTTT(C/T)TAATG intron-variant
rs10476191 -- 176,375,291(+) ACCCA(C/T)CCATC intron-variant
rs10603932 -- 176,387,609(+) GGCAG(-/GCAG)AGAAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARL10 Gene

Variant ID Type Subtype PubMed ID
nsv600341 CNV gain 21841781
nsv462549 CNV gain 19166990
nsv1023853 CNV gain 25217958
esv2731168 CNV deletion 23290073
esv2731167 CNV deletion 23290073

Variation tolerance for ARL10 Gene

Residual Variation Intolerance Score: 37.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.91% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARL10 Gene

Disorders for ARL10 Gene

Relevant External Links for ARL10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL10

No disorders were found for ARL10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARL10 Gene

Publications for ARL10 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors. (PMID: 15033445) Louro R. … Reis E.M. (Biochem. Biophys. Res. Commun. 2004) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for ARL10 Gene

Sources for ARL10 Gene

Content
Loading form....