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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARL10 Gene

protein-coding GIFtS: 43
GCID: GC05P175792

ADP-ribosylation factor-like 10

(Previous name: ADP-ribosylation factor-like 10A )
(Previous symbol: ARL10A)

Explore 1 disease affiliated with
ARL10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
ADP-Ribosylation Factor-Like 10¹ ²
ARL10A¹ ² ³
ADP-Ribosylation Factor-Like 10A¹ ²
ADP-Ribosylation Factor-Like Membrane-Associated Protein²
ADP-Ribosylation Factor-Like Protein 10²

External Ids:	HGNC: 22042¹	Entrez Gene: 285598²	Ensembl: ENSG00000175414⁷	UniProtKB: Q8N8L6³

Export aliases for ARL10 gene to outside databases

Previous GC identifers: GC05P175726 GC05P170718

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_023133.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARL10 gene promoter:
LHX3b/Lhx3b AML1a CUTL1 Tal-1beta AREB6 RORalpha1 Nkx6-1 FOXO3a LHX3a/Lhx3a ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARL10 promoter sequence

Search SABiosciences Chromatin IP Primers for ARL10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q35.2 Ensembl cytogenetic band: 5q35.2 HGNC cytogenetic band: 5q35.3

ARL10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL10 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05P175792: view genomic region (about GC identifiers)

Start:	175,792,471 bp from pter	End:	175,828,866 bp from pter
Size:	36,396 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARL10_HUMAN, Q8N8L6 (See protein sequence)

Recommended Name: ADP-ribosylation factor-like protein 10

Size: 244 amino acids; 27459 Da

Explore the universe of human proteins at neXtProt for ARL10: NX_Q8N8L6

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8N8L6

ARL10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_775935.1

ENSEMBL proteins:

ENSP00000308496 ENSP00000421449 ENSP00000424831

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

ARL10 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARL10 for domains About GeneDecksing

2 InterPro domains/families:

IPR006689 Small_GTPase_ARF/SAR

IPR024156 Small_GTPase_ARF

Graphical View of Domain Structure for InterPro Entry Q8N8L6

ProtoNet protein and cluster: Q8N8L6

1 Blocks protein family: IPB006688 ADP-ribosylation factor

UniProtKB/Swiss-Prot: ARL10_HUMAN, Q8N8L6

Similarity: Belongs to the small GTPase superfamily. Arf family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005525	GTP binding	IEA	--

ARL10 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ARL10:

Increased cell number in G2M,

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ARL10

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007264	small GTPase mediated signal transduction	IEA	--

ARL10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARL10
Search CenterWatch for drugs/clinical trials and news about ARL10

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for ARL10 gene:

NM_173664.4

Unigene Cluster for ARL10:

ADP-ribosylation factor-like 10

Hs.424552 [show with all ESTs]

Unigene Representative Sequence: NM_173664

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310389(uc003meb.3 uc003mec.1) ENST00000507151 ENST00000514533

ENST00000503175

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Additional cDNA sequence: BC059361.1

3 DOTS entries:

DT.100001094 DT.101962353 DT.75184927

24/198 AceView cDNA sequences (see all 198):

AI826989 AI767257 AI510794 AI720244 AA384870 AW161344 AA079686 BM695847

AA327643 BM670759 CD300334 AJ571843 BC000587 BM696119 BF435917 AA341399

AI375726 BC007502 BU626737 BP429989 AA357598 BU727706 BM916231 BM696006

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARL10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGTCACTGTG

About this image
See ARL10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARL10

SOURCE GeneReport for Unigene cluster: Hs.424552

SABiosciences Custom PCR Arrays for ARL10

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARL10 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Arl10^{1 , 5}	ADP-ribosylation factor-like 10^{1, 5}	86.97(n)¹ 88.48(a)¹		13 (28.82 cM)⁵ 56795¹ NM_019968.2¹ NP_064352.2¹ 54575015⁵
chicken (Gallus gallus)	Aves	ARL10¹	ADP-ribosylation factor-like 10	64.04(n) 52.19(a)		416229 XM_414552.2 XP_414552.1
lizard (Anolis carolinensis)	Reptilia	ARL10⁶	--	47(a)	1 ↔ 1	GL343548.1(347140-349265)
zebrafish (Danio rerio)	Actinopterygii	LOC560654¹	ADP-ribosylation factor-like protein 9-like	55.21(n) 47.4(a)		560654 XM_684052.3 XP_689144.3
honey bee (Apis mellifera)	Insecta	--	--	23(a)	1 → many	Group8.14(758799-759803)

ENSEMBL Gene Tree for ARL10 (if available)
TreeFam Gene Tree for ARL10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARL10 gene

ARL4A² ARL11² ARF4² ARF5² ARF1² ARL4D² ARL14² ARF3²

ARF6² ARL9² ARL17B² ARL4C² TRIM23²

18/19 SIMAP similar genes for ARL10 using alignment to 5 protein entries: ARL10_HUMAN (see all proteins) (see all similar genes):

ARL3 ARL9 ARL4D ARL5A ARL8B ARL5B

ARL1 ARL2 ARL4C ARF5 ARF6 ARL14

ARF1 ARF4 ARL8A ARL11 ARL4A ARL6

ARL10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189596784^1,2		--	175791059(+)	`CAGGAC/TGGTCT`	1	--	us2k¹		0	--	--	--	--
rs181525479^1,2		--	175791180(+)	`TTTTCC/TCCTCT`	1	--	us2k¹		0	--	--	--	--
rs11409748^1,2	C	--	175791225(+)	`TTTTTT/-GAGAC`	1	--	us2k¹ trp³		1		NA	2
rs186854281^1,2		--	175791248(+)	`ACGGAA/TTCTTG`	1	--	us2k¹		0	--	--	--	--
rs112987348^1,2		--	175791353(+)	`AGTAGG/TTGGGA`	1	--	us2k¹		1		CSA	2
rs142928534^1,2		--	175791428(+)	`GGCTAC/TTCTCG`	1	--	us2k¹		0	--	--	--	--
rs13362180^1,2	C,	--	175791509(+)	`cacccG/AgccAG`	1	--	us2k¹		1		CSA	2
rs191285627^1,2		--	175791659(+)	`CCAGGA/GGTACA`	1	--	us2k¹		0	--	--	--	--
rs13357812^1,2	C,A	--	175791675(+)	`ATCGCA/GAACTA`	1	--	us2k¹		0	--	--	--	--
rs183032400^1,2		--	175791702(+)	`TGAGAC/TAATAT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for ARL10 (175792471 - 175828866 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARL10: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

ARL10 for disorders About GeneDecksing

1 disease for ARL10: About MalaCards

prostatitis

Export disorders for ARL10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARL10 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARL10)

Utopia: connect your pdf to the dynamic
world of online information

Rasl11a, member of a novel small monomeric GTPase gene family, is differentially expressed in prostate tumors. (PubMed id 15033445)^{1, 2} Louro R.... Reis E.M. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 285598	HGNC: 22042	AceView: MGC2198andARL10A	Ensembl:ENSG00000175414	euGenes: HUgn285598
ECgene: ARL10	H-InvDB: ARL10

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARL10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARL10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for ARL10 gene:
Search GeneIP for patents involving ARL10

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL10

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes ARL10 gene at Home site.

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ARL10 Gene

ADP-ribosylation factor-like 10

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Export list of displayed genes

ARL10 Gene

ADP-ribosylation factor-like 10

Aliasesfor ARL10 gene

Summariesfor ARL10 gene

Genomic Viewsfor ARL10 gene

Proteinsfor ARL10 gene

Protein Domains /Familiesfor ARL10 gene

Functionfor ARL10 gene

Pathways & Interactionsfor ARL10 gene

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Genome Databases showing ARL10 gene

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for ARL10 gene

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for ARL10 gene

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for ARL10 gene

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for ARL10 gene

Protein Domains /
Families
for ARL10 gene

Function
for ARL10 gene

Pathways & Interactions
for ARL10 gene

Drugs & Compounds
for ARL10 gene

Transcripts
for ARL10 gene

Expression
for ARL10 gene

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for ARL10 gene

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for ARL10 gene

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for ARL10 gene

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for ARL10 gene

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for ARL10 gene

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for ARL10 gene

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for ARL10 gene