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Aliases for ARL1 Gene

Aliases for ARL1 Gene

  • ADP Ribosylation Factor Like GTPase 1 2 3 5
  • ADP-Ribosylation Factor-Like 1 2 3
  • ADP-Ribosylation Factor-Like Protein 1 3
  • ARFL1 3

External Ids for ARL1 Gene

Previous GeneCards Identifiers for ARL1 Gene

  • GC12M100928
  • GC12M101772
  • GC12M101719
  • GC12M100291
  • GC12M100289
  • GC12M101786
  • GC12M098846

Summaries for ARL1 Gene

Entrez Gene Summary for ARL1 Gene

  • The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for ARL1 Gene

ARL1 (ADP Ribosylation Factor Like GTPase 1) is a Protein Coding gene. Diseases associated with ARL1 include Cholera and Chylomicron Retention Disease. Among its related pathways are Vesicle-mediated transport and Retrograde transport at the Trans-Golgi-Network. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL8A.

UniProtKB/Swiss-Prot for ARL1 Gene

  • GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.

Gene Wiki entry for ARL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL1 Gene

Genomics for ARL1 Gene

Regulatory Elements for ARL1 Gene

Enhancers for ARL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F101406 1.1 ENCODE 28.2 +0.1 87 3.0 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ARL1 UTP20
GH12F101279 1 ENCODE 19.3 +127.6 127594 1.5 ARID4B SIN3A DMAP1 ZNF48 ZNF2 ETS1 YY1 SLC30A9 ZNF143 SP3 ARL1 NUP37 UTP20
GH12F101695 1.1 ENCODE 10.3 -290.9 -290868 6.9 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF263 SP3 SP5 CHPT1 ARL1 GNPTAB GC12P101721
GH12F101582 0.4 ENCODE 10.4 -176.0 -176029 2.7 SIX4 CHPT1 SPIC RNA5SP367 RNU5E-5P SYCP3 ARL1 RNU6-101P MYBPC1 LOC105369938
GH12F101356 0.4 Ensembl 0.2 +51.0 51020 0.4 EGR2 ARL1 UTP20
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARL1 on UCSC Golden Path with GeneCards custom track

Promoters for ARL1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090458 120 3001 HDGF ARNT CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143

Genomic Location for ARL1 Gene

Chromosome:
12
Start:
101,393,120 bp from pter
End:
101,407,820 bp from pter
Size:
14,701 bases
Orientation:
Minus strand

Genomic View for ARL1 Gene

Genes around ARL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL1 Gene

Proteins for ARL1 Gene

  • Protein details for ARL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40616-ARL1_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 1
    Protein Accession:
    P40616
    Secondary Accessions:
    • B4DWW1
    • P80417
    • Q53XB1

    Protein attributes for ARL1 Gene

    Size:
    181 amino acids
    Molecular mass:
    20418 Da
    Quaternary structure:
    • The GTP-bound form interacts with GOLGA1 (By similarity). The GTP-bound form interacts with GOLGA4 and RGPD8. The GTP-bound form directly interacts with ARFIP2; this interaction leads to a > 4-fold increase in the amount of bound GTP at steady state level. Binds to SCOC, preferentially in its GTP-bound form. May interact with UNC119.

    Three dimensional structures from OCA and Proteopedia for ARL1 Gene

    Alternative splice isoforms for ARL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL1 Gene

Post-translational modifications for ARL1 Gene

  • Ubiquitination at Lys 62 and Lys 157
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARL1 Gene

Domains & Families for ARL1 Gene

Gene Families for ARL1 Gene

Graphical View of Domain Structure for InterPro Entry

P40616

UniProtKB/Swiss-Prot:

ARL1_HUMAN :
  • Belongs to the small GTPase superfamily. Arf family.
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL1: view

Function for ARL1 Gene

Molecular function for ARL1 Gene

GENATLAS Biochemistry:
ADP-ribosylation factor-like 1,low molecular weight GTP binding protein,widely expressed,except in brain,Ras superfamily member
UniProtKB/Swiss-Prot Function:
GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.

Gene Ontology (GO) - Molecular Function for ARL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IDA 8798635
GO:0005525 GTP binding IEA,IDA 9624189
GO:0008047 enzyme activator activity IDA 9624189
GO:0019904 protein domain specific binding IPI 14580338
genes like me logo Genes that share ontologies with ARL1: view
genes like me logo Genes that share phenotypes with ARL1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for ARL1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARL1 Gene

Localization for ARL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL1 Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Membrane; Lipid-anchor.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARL1 gene
Compartment Confidence
extracellular 5
cytosol 5
golgi apparatus 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus IEA,IDA 19224922
GO:0005802 trans-Golgi network ISS,IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARL1: view

Pathways & Interactions for ARL1 Gene

genes like me logo Genes that share pathways with ARL1: view

Gene Ontology (GO) - Biological Process for ARL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007030 Golgi organization ISS --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0009404 toxin metabolic process IDA 9624189
GO:0031584 activation of phospholipase D activity IDA 9624189
GO:0034067 protein localization to Golgi apparatus IMP 19224922
genes like me logo Genes that share ontologies with ARL1: view

No data available for SIGNOR curated interactions for ARL1 Gene

Drugs & Compounds for ARL1 Gene

(1) Drugs for ARL1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma Target 0

(1) Additional Compounds for ARL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARL1: view

Transcripts for ARL1 Gene

Unigene Clusters for ARL1 Gene

ADP-ribosylation factor-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for ARL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: - - - - - -
SP6: -

Relevant External Links for ARL1 Gene

GeneLoc Exon Structure for
ARL1
ECgene alternative splicing isoforms for
ARL1

Expression for ARL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARL1 Gene

This gene is overexpressed in Nasal epithelium (9.6) and Salivary gland (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARL1 Gene



Protein tissue co-expression partners for ARL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARL1 Gene:

ARL1

SOURCE GeneReport for Unigene cluster for ARL1 Gene:

Hs.372616

mRNA Expression by UniProt/SwissProt for ARL1 Gene:

P40616-ARL1_HUMAN
Tissue specificity: Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney. Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with ARL1: view

Primer Products

No data available for mRNA differential expression in normal tissues for ARL1 Gene

Orthologs for ARL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL1 34 35
  • 99.82 (n)
oppossum
(Monodelphis domestica)
Mammalia ARL1 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL1 34 35
  • 95.4 (n)
cow
(Bos Taurus)
Mammalia ARL1 34 35
  • 95.03 (n)
mouse
(Mus musculus)
Mammalia Arl1 34 16 35
  • 91.9 (n)
rat
(Rattus norvegicus)
Mammalia Arl1 34
  • 91.71 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 44 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ARL1 34 35
  • 82.44 (n)
lizard
(Anolis carolinensis)
Reptilia ARL1 35
  • 97 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arl1 34
  • 82.04 (n)
Str.4004 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.24080 34
zebrafish
(Danio rerio)
Actinopterygii arl1 34 35
  • 79.44 (n)
Dr.28553 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13814 34
fruit fly
(Drosophila melanogaster)
Insecta Arf72A 36 34 35
  • 66.07 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011730 34
  • 64.27 (n)
worm
(Caenorhabditis elegans)
Secernentea arl-1 36 34 35
  • 64.07 (n)
arl-6 36
  • 51 (a)
arl-5 36
  • 48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARL1 34 35 37
  • 62.48 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24773g 34
  • 60.64 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR221W 34
  • 57.68 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARF3 34
  • 62.63 (n)
rice
(Oryza sativa)
Liliopsida Os08g0248900 34
  • 61.85 (n)
corn
(Zea mays)
Liliopsida Zm.8989 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.887 35
  • 77 (a)
OneToOne
bread mold
(Neurospora crassa)
Ascomycetes NCU08989 34
  • 59.3 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15548 34
Species where no ortholog for ARL1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL1 Gene

ENSEMBL:
Gene Tree for ARL1 (if available)
TreeFam:
Gene Tree for ARL1 (if available)

Paralogs for ARL1 Gene

Paralogs for ARL1 Gene

genes like me logo Genes that share paralogs with ARL1: view

Variants for ARL1 Gene

Sequence variations from dbSNP and Humsavar for ARL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10467015 -- 101,405,244(+) TAATC(A/G)ATATA intron-variant
rs10467016 -- 101,405,493(+) CCGGC(C/T)GTAAA intron-variant
rs10507131 -- 101,407,119(+) CAGCA(C/G)ATTAG intron-variant
rs1061351 -- 101,395,455(-) GAATC(A/C)CCTGA utr-variant-3-prime
rs10745914 -- 101,397,558(+) GCAGT(C/G)GTGCA intron-variant

Variation tolerance for ARL1 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.38; 8.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARL1 Gene

Disorders for ARL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARL1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cholera
  • cholera - vibrio cholerae
chylomicron retention disease
  • retinitis pigmentosa
- elite association - COSMIC cancer census association via MalaCards
Search ARL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for ARL1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARL1
genes like me logo Genes that share disorders with ARL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARL1 Gene

Publications for ARL1 Gene

  1. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H. … Kahn R.A. (J. Biol. Chem. 2001) 3 4 22 64
  2. Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). (PMID: 9624189) Hong J.-X. … Vaughan M. (J. Biol. Chem. 1998) 3 4 22 64
  3. Different ARF domains are required for the activation of cholera toxin and phospholipase D. (PMID: 7814376) Zhang G.-F. … Vaughan M. (J. Biol. Chem. 1995) 3 4 22 64
  4. Differential effects of depletion of ARL1 and ARFRP1 on membrane trafficking between the trans-Golgi network and endosomes. (PMID: 19224922) Nishimoto-Morita K. … Nakayama K. (J. Biol. Chem. 2009) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for ARL1 Gene

Sources for ARL1 Gene

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