External Ids for ARL1 Gene
Previous GeneCards Identifiers for ARL1 Gene
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
GeneCards Summary for ARL1 Gene
ARL1 (ADP-Ribosylation Factor-Like 1) is a Protein Coding gene. Diseases associated with ARL1 include cholera. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL15.
UniProtKB/Swiss-Prot for ARL1 Gene
GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.