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Aliases for ARL1 Gene

Aliases for ARL1 Gene

  • ADP-Ribosylation Factor-Like 1 2 3
  • ADP-Ribosylation Factor-Like Protein 1 3
  • ARFL1 3

External Ids for ARL1 Gene

Previous GeneCards Identifiers for ARL1 Gene

  • GC12M100928
  • GC12M101772
  • GC12M101719
  • GC12M100291
  • GC12M100289
  • GC12M101786
  • GC12M098846

Summaries for ARL1 Gene

Entrez Gene Summary for ARL1 Gene

  • The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

GeneCards Summary for ARL1 Gene

ARL1 (ADP-Ribosylation Factor-Like 1) is a Protein Coding gene. Diseases associated with ARL1 include cholera. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is ARL15.

UniProtKB/Swiss-Prot for ARL1 Gene

  • GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.

Gene Wiki entry for ARL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARL1 Gene

Genomics for ARL1 Gene

Regulatory Elements for ARL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARL1 Gene

Start:
101,393,116 bp from pter
End:
101,408,400 bp from pter
Size:
15,285 bases
Orientation:
Minus strand

Genomic View for ARL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARL1 Gene

Proteins for ARL1 Gene

  • Protein details for ARL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P40616-ARL1_HUMAN
    Recommended name:
    ADP-ribosylation factor-like protein 1
    Protein Accession:
    P40616
    Secondary Accessions:
    • B4DWW1
    • P80417
    • Q53XB1

    Protein attributes for ARL1 Gene

    Size:
    181 amino acids
    Molecular mass:
    20418 Da
    Quaternary structure:
    • The GTP-bound form interacts with GOLGA1 (By similarity). The GTP-bound form interacts with GOLGA4 and RGPD8. The GTP-bound form directly interacts with ARFIP2; this interaction leads to a > 4-fold increase in the amount of bound GTP at steady state level. Binds to SCOC, preferentially in its GTP-bound form. May interact with UNC119.

    Three dimensional structures from OCA and Proteopedia for ARL1 Gene

    Alternative splice isoforms for ARL1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARL1 Gene

Proteomics data for ARL1 Gene at MOPED

Post-translational modifications for ARL1 Gene

  • Ubiquitination at Lys62 and Lys157
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARL1 Gene

Domains for ARL1 Gene

Gene Families for ARL1 Gene

HGNC:
  • ARF :ADP-ribosylation factors
  • ARL :ADP-ribosylation factors-like

Protein Domains for ARL1 Gene

Graphical View of Domain Structure for InterPro Entry

P40616

UniProtKB/Swiss-Prot:

ARL1_HUMAN :
  • P40616
Family:
  • Belongs to the small GTPase superfamily. Arf family.
genes like me logo Genes that share domains with ARL1: view

Function for ARL1 Gene

Molecular function for ARL1 Gene

GENATLAS Biochemistry: ADP-ribosylation factor-like 1,low molecular weight GTP binding protein,widely expressed,except in brain,Ras superfamily member
UniProtKB/Swiss-Prot Function: GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.

Gene Ontology (GO) - Molecular Function for ARL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IDA 8798635
GO:0004871 signal transducer activity --
GO:0005525 GTP binding IDA 9624189
GO:0008047 enzyme activator activity IDA 9624189
GO:0019001 guanyl nucleotide binding --
genes like me logo Genes that share ontologies with ARL1: view
genes like me logo Genes that share phenotypes with ARL1: view

Animal Model Products

CRISPR Products

miRNA for ARL1 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARL1 Gene

Localization for ARL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARL1 Gene

Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARL1 Gene COMPARTMENTS Subcellular localization image for ARL1 gene
Compartment Confidence
golgi apparatus 5
cytosol 2
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005737 cytoplasm ISS --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with ARL1: view

Pathways for ARL1 Gene

SuperPathways for ARL1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006184 obsolete GTP catabolic process --
GO:0006886 intracellular protein transport --
GO:0007030 Golgi organization ISS --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0007264 small GTPase mediated signal transduction IEA --
genes like me logo Genes that share ontologies with ARL1: view

No data available for Pathways by source for ARL1 Gene

Compounds for ARL1 Gene

(1) Drugbank Compounds for ARL1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Guanosine-5'-Diphosphate
146-91-8 target

(1) Novoseek inferred chemical compound relationships for ARL1 Gene

Compound -log(P) Hits PubMed IDs
gtp 33.6 1
genes like me logo Genes that share compounds with ARL1: view

Transcripts for ARL1 Gene

Unigene Clusters for ARL1 Gene

ADP-ribosylation factor-like 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARL1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: -
SP4: - - - -
SP5: - - - - - -
SP6: -

Relevant External Links for ARL1 Gene

GeneLoc Exon Structure for
ARL1
ECgene alternative splicing isoforms for
ARL1

Expression for ARL1 Gene

mRNA expression in normal human tissues for ARL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARL1 Gene

SOURCE GeneReport for Unigene cluster for ARL1 Gene Hs.372616

mRNA Expression by UniProt/SwissProt for ARL1 Gene

P40616-ARL1_HUMAN
Tissue specificity: Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver and kidney. Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with ARL1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARL1 Gene

Orthologs for ARL1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARL1 35
  • 99.82 (n)
  • 100 (a)
ARL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARL1 35
  • 95.03 (n)
  • 99.45 (a)
ARL1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARL1 35
  • 95.4 (n)
  • 99.45 (a)
ARL1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arl1 35
  • 91.9 (n)
  • 98.9 (a)
Arl1 16
Arl1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARL1 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Arl1 35
  • 91.71 (n)
  • 98.9 (a)
chicken
(Gallus gallus)
Aves ARL1 35
  • 82.44 (n)
  • 96.41 (a)
ARL1 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARL1 36
  • 97 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24080 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arl1 35
  • 82.04 (n)
  • 96.41 (a)
Str.4004 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13814 35
zebrafish
(Danio rerio)
Actinopterygii arl1 35
  • 79.44 (n)
  • 95.21 (a)
arl1 36
  • 94 (a)
OneToOne
Dr.28553 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011730 35
  • 64.27 (n)
  • 79.04 (a)
fruit fly
(Drosophila melanogaster)
Insecta Arf72A 35
  • 66.07 (n)
  • 80.84 (a)
Arf72A 36
  • 79 (a)
OneToOne
Arf72A 37
  • 77 (a)
worm
(Caenorhabditis elegans)
Secernentea arl-1 35
  • 64.07 (n)
  • 73.05 (a)
arl-1 36
  • 72 (a)
OneToOne
arl-6 37
  • 51 (a)
arl-1 37
  • 71 (a)
arl-5 37
  • 48 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR221W 35
  • 57.68 (n)
  • 65.27 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ARL1 35
  • 62.48 (n)
  • 64.67 (a)
ARL1 36
  • 63 (a)
OneToMany
ARL1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E24773g 35
  • 60.64 (n)
  • 65.06 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons ARF3 35
  • 62.63 (n)
  • 66.06 (a)
corn
(Zea mays)
Liliopsida Zm.8989 35
rice
(Oryza sativa)
Liliopsida Os08g0248900 35
  • 61.85 (n)
  • 65.06 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU08989 35
  • 59.3 (n)
  • 65.64 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.15548 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.887 36
  • 77 (a)
OneToOne
Species with no ortholog for ARL1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARL1 Gene

ENSEMBL:
Gene Tree for ARL1 (if available)
TreeFam:
Gene Tree for ARL1 (if available)

Paralogs for ARL1 Gene

Paralogs for ARL1 Gene

genes like me logo Genes that share paralogs with ARL1: view

Variants for ARL1 Gene

Sequence variations from dbSNP and Humsavar for ARL1 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs13387 -- 101,393,313(-) AAAAT(A/T)TGAGA utr-variant-3-prime
rs1061351 -- 101,395,455(-) GAATC(A/C)CCTGA utr-variant-3-prime
rs1311244 -- 101,392,750(-) acctc(C/T)gcctc downstream-variant-500B
rs1312029 -- 101,392,698(-) tggga(C/T)tacag downstream-variant-500B
rs1312285 -- 101,392,722(-) tcctg(C/G)ctcag downstream-variant-500B

Relevant External Links for ARL1 Gene

HapMap Linkage Disequilibrium report
ARL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARL1 Gene

Disorders for ARL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARL1 Gene including...

Search for ARL1 Gene in MalaCards »

(1) Novoseek inferred disease relationships for ARL1 Gene

Disease -log(P) Hits PubMed IDs
cholera 55 2
genes like me logo Genes that share disorders with ARL1: view

No data available for UniProtKB/Swiss-Prot for ARL1 Gene

Publications for ARL1 Gene

  1. Different ARF domains are required for the activation of cholera toxin and phospholipase D. (PMID: 7814376) Zhang G.-F. … Vaughan M. (J. Biol. Chem. 1995) 3 4 23
  2. Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). (PMID: 9624189) Hong J.-X. … Vaughan M. (J. Biol. Chem. 1998) 3 4 23
  3. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PMID: 11303027) Van Valkenburgh H. … Kahn R.A. (J. Biol. Chem. 2001) 3 4 23
  4. Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network. (PMID: 15269279) Lu L. … Hong W. (Mol. Biol. Cell 2004) 3 23
  5. Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. (PMID: 14580338) Panic B. … Munro S. (Mol. Cell 2003) 3 4

Products for ARL1 Gene

Sources for ARL1 Gene

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