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ARL1 Gene

protein-coding   GIFtS: 59
GCID: GC12M101786

ADP-Ribosylation Factor-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
ADP-Ribosylation Factor-Like 11 2
ARFL12
ADP-Ribosylation Factor-Like Protein 12

External Ids:    HGNC: 6921   Entrez Gene: 4002   Ensembl: ENSG000001208057   OMIM: 6034255   UniProtKB: P406163   

Export aliases for ARL1 gene to outside databases

Previous GC identifers: GC12M100928 GC12M101772 GC12M101719 GC12M100291 GC12M100289 GC12M098846


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARL1 Gene:
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are
structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT)
ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a
phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later
work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. (provided by RefSeq,
Jul 2008)

GeneCards Summary for ARL1 Gene:
ARL1 (ADP-ribosylation factor-like 1) is a protein-coding gene. Diseases associated with ARL1 include cholera, and malaria. GO annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is ARL15.

UniProtKB/Swiss-Prot: ARL1_HUMAN, P40616
Function: GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic
subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal
function of the Golgi apparatus

Gene Wiki entry for ARL1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARL1 gene promoter:
         C/EBPbeta   p53   Pbx1a   FOXF2   Brachyury   RORalpha2   Egr-2   POU2F1   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARL1 promoter sequence
   Search Chromatin IP Primers for ARL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23.3

ARL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M101786:  view genomic region     (about GC identifiers)

Start:
101,786,898 bp from pter      End:
101,801,598 bp from pter
Size:
14,701 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARL1_HUMAN, P40616 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 1  
Size: 181 amino acids; 20418 Da
Subunit: The GTP-bound form interacts with GOLGA1 (By similarity). The GTP-bound form interacts with GOLGA4 and
RGPD8. The GTP-bound form directly interacts with ARFIP2; this interaction leads to a > 4-fold increase in the
amount of bound GTP at steady state level. Binds to SCOC, preferentially in its GTP-bound form. May interact with
UNC119
2 PDB 3D structures from and Proteopedia for ARL1:
1UPT (3D)        4DCN (3D)    
Secondary accessions: P80417 Q53XB1

Explore the universe of human proteins at neXtProt for ARL1: NX_P40616

Explore proteomics data for ARL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys62, Lys157
  • Modification sites at PhosphoSitePlus

  • See ARL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001168.1  
    ENSEMBL proteins: 
     ENSP00000261636   ENSP00000439590   ENSP00000441808   ENSP00000447405   ENSP00000448850  
     ENSP00000448912   ENSP00000450162   ENSP00000450315  

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    Novus Biologicals ARL1 Proteins
    Novus Biologicals ARL1 Lysate
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    Cloud-Clone Corp. Proteins for ARL1

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    ARL1 Assay Products:

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    Cloud-Clone Corp. CLIAs for ARL1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARL: ADP-ribosylation factors-like
    ARF: ADP-ribosylation factors

    4 InterPro protein domains:
     IPR005225 Small_GTP-bd_dom
     IPR027417 P-loop_NTPase
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF

    Graphical View of Domain Structure for InterPro Entry P40616

    ProtoNet protein and cluster: P40616

    1 Blocks protein domain: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL1_HUMAN, P40616
    Similarity: Belongs to the small GTPase superfamily. Arf family


    ARL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARL1_HUMAN, P40616
    Function: GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic
    subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal
    function of the Golgi apparatus

         Genatlas biochemistry entry for ARL1:
    ADP-ribosylation factor-like 1,low molecular weight GTP binding protein,widely expressed,except in brain,Ras
    superfamily member

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA8798635
    GO:0004871signal transducer activity ----
    GO:0005525GTP binding IDA9624189
    GO:0008047enzyme activator activity IDA9624189
    GO:0019001guanyl nucleotide binding ----
         
    ARL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARL1:
     Decreased Hepatitis C virus re  Upregulation of Wnt/beta-caten 

         1 MGI phenotypic allele for Arl1 (no phenotypes)

    ARL1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARL1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARL1:
    hsa-mir-93-5p (MIRT028155), hsa-mir-24-3p (MIRT030486), hsa-mir-769-5p (MIRT039171), hsa-mir-130b-3p (MIRT020262)

    Block miRNA regulation of human, mouse, rat ARL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL1 (see all 44):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-300 hsa-miR-106a hsa-miR-548k hsa-miR-519a hsa-miR-9 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidARL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ARL1
    Predesigned siRNA for gene silencing in human, mouse, rat ARL1

    Gene Editing
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    Clone
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    OriGene ORF clones in mouse, rat for ARL1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARL1 (NM_001177)
    Sino Biological Human cDNA Clone for ARL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL1

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARL1_HUMAN, P40616: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    golgi apparatus5
    cytosol2
    extracellular2
    mitochondrion1
    nucleus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005634nucleus ----
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus IDA--

    ARL1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARL1
    Interactions:

        GeneGlobe Interaction Network for ARL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARL1 (P406163 ENSP000002616364) via UniProtKB, MINT, STRING, and/or I2D (see all 201)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000206286Q8N1B43I2D: score=1 
    ENSG00000224455Q8N1B43I2D: score=1 
    ENSG00000225590Q8N1B43I2D: score=1 
    ENSG00000228425Q8N1B43I2D: score=1 
    ENSG00000236014Q8N1B43I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA8798635
    GO:0006886intracellular protein transport ----
    GO:0007030Golgi organization ISS--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0007264small GTPase mediated signal transduction IEA--

    ARL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARL1

    1 DrugBank Compound for ARL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--10592235

    1 Novoseek inferred chemical compound relationship for ARL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 33.6 2 9388248 (1)



    ARL1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARL1 gene: 
    NM_001177.4  

    Unigene Cluster for ARL1:

    ADP-ribosylation factor-like 1
    Hs.372616  [show with all ESTs]
    Unigene Representative Sequence: NM_001177
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261636(uc001tib.3 uc010svn.2 uc010svo.2) ENST00000539055
    ENST00000536227 ENST00000551688 ENST00000550597 ENST00000551828 ENST00000551671
    ENST00000551092 ENST00000549283 ENST00000549302 ENST00000548070
    miRNA
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    Block miRNA regulation of human, mouse, rat ARL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARL1 (see all 44):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-300 hsa-miR-106a hsa-miR-548k hsa-miR-519a hsa-miR-9 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidARL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARL1
    Predesigned siRNA for gene silencing in human, mouse, rat ARL1
    Clone
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    GenScript: all cDNA clones in your preferred vector: ARL1 (NM_001177)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL1
    Primer
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    OriGene qPCR primer pairs and template standards for ARL1
    OriGene qSTAR qPCR primer pairs in human, mouse for ARL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARL1
      QuantiTect SYBR Green Assays in human, mouse, rat ARL1
      QuantiFast Probe-based Assays in human, mouse, rat ARL1

    Additional mRNA sequence: 

    AF493887.1 AK001489.1 AK299062.1 AK301701.1 AK302911.1 AK311793.1 BC007000.1 BT007260.1 
    BX537387.1 L28997.1 

    14 DOTS entries:

    DT.444264  DT.100711542  DT.100811226  DT.121110841  DT.412382  DT.86851451  DT.121110832  DT.91767595 
    DT.100811228  DT.121110804  DT.121110809  DT.91767593  DT.92419699  DT.97767329 

    Selected AceView cDNA sequences (see all 341):

    CD518290 CB131891 AF493887 AI688679 AA622011 AW468490 NM_001177 BM351860 
    BG434380 AI302576 CR596544 CR595963 AI313185 AI093193 AL701988 CB122395 
    BU627392 CR596591 AI092621 AA455083 BE671606 AI590307 CA773643 AA027906 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARL1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                                      -                 -                     
    SP2:                    -     -           -                                       
    SP3:                                      -                                       
    SP4:                    -     -     -     -                                       
    SP5:                    -     -     -     -     -           -                     


    ECgene alternative splicing isoforms for ARL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAATCTGA
    ARL1 Expression
    About this image


    ARL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Intermediate Mesoderm (Gastrulation Derivatives)    fully expand to see all 2 entries
             Mesonephric cells Mesonephros
             Mesonephros
     
     Gonad
             Mesonephric cells Mesonephros
     
     Testis (Reproductive System)
    ARL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.372616

    UniProtKB/Swiss-Prot: ARL1_HUMAN, P40616
    Tissue specificity: Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung,
    liver and kidney. Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas

        Custom PCR Arrays for ARL1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARL1
    QuantiTect SYBR Green Assays in human, mouse, rat ARL1
    QuantiFast Probe-based Assays in human, mouse, rat ARL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARL1 gene from Selected species (see all 26)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arl11 , 5 ADP-ribosylation factor-like 11, 5 91.9(n)1
    98.9(a)1
      10 (44.19 cM)5
    1043031  NM_025859.31  NP_080135.21 
     887308585 
    chicken
    (Gallus gallus)
    Aves ARL11 ADP-ribosylation factor-like 1 82.44(n)
    96.41(a)
      417934  NM_001081494.1  NP_001074963.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARL16
    ADP-ribosylation factor-like 1
    97(a)
    1 ↔ 1
    5(28216468-28222060)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.240802 Xenopus laevis transcribed sequence with strong similarity more 82.37(n)    BJ058168.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.285532 Transcribed sequence with strong similarity to protein more 79.26(n)    CK354300.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Arf72A1 , 3 protein amino acid ADP-ribosylation GTP
    binding3
    Arflike at 72A1
    77(a)3
    66.07(n)1
    80.84(a)1
      72C13
    397451  NM_079374.41  NP_524098.21 
    worm
    (Caenorhabditis elegans)
    Secernentea arl-11 , 3 GTP-binding ADP-ribosylation factor3
    arl-11
    71(a)
    (best of 3)3
    64.07(n)1
    73.05(a)1
      II(8581835-8582638)3
    1743751  NM_063415.61  NP_495816.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ARL1(YBR164C)4
    ARL11
    Soluble GTPase with a role in regulation of membrane more4
    ARL11
    62.48(n)1
    64.67(a)1
      2(568426-567875)4
    8524621, 4  NP_009723.31  NP_009723.14 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARF31 ARF3 62.63(n)
    66.06(a)
      817014  NM_179726.2  NP_850057.1 
    rice
    (Oryza sativa)
    Liliopsida Os08g02489001 Os08g0248900 61.85(n)
    65.06(a)
      4345072  NM_001067903.1  NP_001061368.1 


    ENSEMBL Gene Tree for ARL1 (if available)
    TreeFam Gene Tree for ARL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARL1 gene
    ARL152  ARL92  ARL62  ARL8A2  ARL8B2  ARL102  
    Selected SIMAP similar genes for ARL1 using alignment to 7 protein entries:     ARL1_HUMAN (see all proteins) (see all similar genes):
    ARL17B    ARL17A    ARF3    ARF1    ARF5    ARF6
    ARF4    ARL3    ARL2    ARL5B    ARL5A    ARL6
    ARL14    ARL4A    ARL7    ARL8A    ARL8B    ARL10

    ARL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARL1 (see all 302)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1929793241,2
    --101786504(+) GCCAGA/GAGAAT 1 -- ds50010--------
    rs285324451,2
    --101786511(+) GAATCA/GCTTGC 1 -- ds50010--------
    rs286881581,2
    --101786605(+) AAAAAA/CAAAAA 1 -- ds50010--------
    rs2001948761,2
    C--101786618(-) CTTTTG/TTTTTT 1 -- ds50010--------
    rs3763590291,2
    C--101786618(+) AAAAA-/CAAAAG 1 -- ds50010--------
    rs756727011,2
    F--101786745(+) ATTCTC/TACGCT 1 -- ds50011Minor allele frequency- T:0.06WA 118
    rs1874259361,2
    --101786810(+) TTAATC/TCTAAG 1 -- ds50010--------
    rs1921718391,2
    C--101787049(+) GTGCAC/TCTCAG 1 -- ut310--------
    rs1847596121,2
    --101787064(+) TTCAGA/TTAACA 1 -- ut310--------
    rs133871,2
    C,F--101787091(-) AAAATT/ATGAGA 1 -- ut314Minor allele frequency- A:0.04MN WA CSA 306

    HapMap Linkage Disequilibrium report for ARL1 (101786898 - 101801598 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARL1: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARL1
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603425    OMIM disorders: --

    5 diseases for ARL1:    
    About MalaCards
    cholera    malaria    melanoma    prostate cancer
    prostatitis


    ARL1 for disorders           About GeneDecksing

    1 Novoseek inferred disease relationship for ARL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 55 3 7814376 (2)


    Export disorders for ARL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARL1 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with ARL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PubMed id 11303027)1, 2, 9 Van Valkenburgh H.... Kahn R.A. (J. Biol. Chem. 2001)
    2. Different ARF domains are required for the activation of cholera toxin and phospholipase D. (PubMed id 7814376)1, 2, 9 Zhang G.-F.... Vaughan M. (J. Biol. Chem. 1995)
    3. Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). (PubMed id 9624189)1, 2, 9 Hong J.-X.... Vaughan M. (J. Biol. Chem. 1998)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. (PubMed id 14580338)1, 2 Panic B.... Munro S. (Mol. Cell 2003)
    7. Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network. (PubMed id 15269279)1, 9 Lu L....Hong W. (Mol. Biol. Cell 2004)
    8. Arl1p regulates spatial membrane organization at the trans-Golgi network through interaction with Arf-GEF Gea2p and flippase Drs2p. (PubMed id 23345439)1 Tsai P.C....Lee F.J. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 400 HGNC: 692 AceView: ARL1 Ensembl:ENSG00000120805 euGenes: HUgn400
    ECgene: ARL1 H-InvDB: ARL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARL1 gene:
    Search GeneIP for patents involving ARL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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