Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARL1 Gene

protein-coding   GIFtS: 57
GCID: GC12M101786

ADP-ribosylation factor-like 1
 Explore 3 diseases affiliated with
ARL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARL1    

Aliases
for ARL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
ADP-Ribosylation Factor-Like 11 2
ARFL11 2
ADP-Ribosylation Factor-Like Protein 12

External Ids:    HGNC: 6921   Entrez Gene: 4002   Ensembl: ENSG000001208057   OMIM: 6034255   UniProtKB: P406163   

Export aliases for ARL1 gene to outside databases

Previous GC identifers: GC12M100928 GC12M101772 GC12M101719 GC12M100291 GC12M100289 GC12M098846


Summaries
for ARL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARL1:
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are
structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT)
ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase
D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they
are weak stimulators of PLD and CT in a phospholipid dependent manner. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARL1_HUMAN, P40616
Function: GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic
subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal
function of the Golgi apparatus

Gene Wiki entry for ARL1


Genomic Views
for ARL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARL1 gene promoter:
         C/EBPbeta   p53   Pbx1a   FOXF2   Brachyury   RORalpha2   Egr-2   POU2F1   Cart-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.2   Ensembl cytogenetic band:  12q23.2   HGNC cytogenetic band: 12q23.3

ARL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARL1 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M101786:  view genomic region     (about GC identifiers)

Start:
 101,786,898 bp from pter      End:
 101,801,598 bp from pter
Size:
 14,701 bases      Orientation:
 minus strand

Proteins
for ARL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARL1_HUMAN, P40616 (See protein sequence)
Recommended Name: ADP-ribosylation factor-like protein 1  
Size: 181 amino acids; 20418 Da
Subunit: The GTP-bound form interacts with GOLGA1 (By similarity). The GTP-bound form interacts with GOLGA4 and RGPD8.
The GTP-bound form directly interacts with ARFIP2; this interaction leads to a > 4-fold increase in the amount of
bound GTP at steady state level. Binds to SCOC, preferentially in its GTP-bound form. May interact with UNC119
Subcellular location: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side
2 PDB 3D structures from and Proteopedia for ARL1:
1UPT (3D)        4DCN (3D)    
Secondary accessions: P80417 Q53XB1

Explore the universe of human proteins at neXtProt for ARL1: NX_P40616

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P40616

    • ARL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001168.1  
    ENSEMBL proteins: 
     ENSP00000261636   ENSP00000439590   ENSP00000441808   ENSP00000447405   ENSP00000448850  
     ENSP00000448912   ENSP00000450162   ENSP00000450315  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ARL1
    OriGene Protein Over-expression Lysate: ARL1
    OriGene Custom Protein Services for ARL1 
    GenScript Custom Purified and Recombinant Proteins Services for ARL1
    Novus Biologicals ARL1 Proteins
    Novus Biologicals ARL1 Lysate
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for ARL1
    Uscn Proteins for ARL1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000139Golgi membrane IEA--
    GO:0005622intracellular ----
    GO:0005737cytoplasm ISS--
    GO:0005794Golgi apparatus IDA--
    GO:0005802trans-Golgi network ISS--


    ARL1 for ontologies           About GeneDecksing



    ARL1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARL1 
    GenScript Custom Superior Antibodies Services for ARL1
    Novus Biologicals ARL1 Antibodies
    Abcam antibodies for ARL1 
    Uscn Antibodies for ARL1
    ThermoFisher Antibodies for ARL1

    Assay Products for ARL1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARL1
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ARL1

    Protein Domains /
    Families
    for ARL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARL1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006689 Small_GTPase_ARF/SAR
     IPR024156 Small_GTPase_ARF
     IPR005225 Small_GTP-bd_dom

    Graphical View of Domain Structure for InterPro Entry P40616

    ProtoNet protein and cluster: P40616

    1 Blocks protein family: IPB006688 ADP-ribosylation factor

    UniProtKB/Swiss-Prot: ARL1_HUMAN, P40616
    Similarity: Belongs to the small GTPase superfamily. Arf family


    Function
    for ARL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARL1_HUMAN, P40616
    Function: GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic
    subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal
    function of the Golgi apparatus

         Genatlas biochemistry entry for ARL1:
    ADP-ribosylation factor-like 1,low molecular weight GTP binding protein,widely expressed,except in brain,Ras
    superfamily member

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ARL1
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARL1
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL1 (see all 44):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-300 hsa-miR-106a hsa-miR-548k hsa-miR-519a hsa-miR-9 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: ARL1 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL1 (see all 7)
    OriGene shRNA RFP: ARL1
    OriGene siRNA: ARL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL1

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARL1

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARL1 (NM_001177)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL1 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ARL1
    Search LifeMap BioReagents cell lines for ARL1

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL1

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003924GTPase activity IDA8798635
    GO:0005525GTP binding IDA9624189
    GO:0008047enzyme activator activity IDA9624189
    GO:0019904protein domain specific binding IPI14580338
    GO:0046872metal ion binding IEA--


    ARL1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ARL1:
     Decreased Hepatitis C virus re  Upregulation of Wnt/beta-caten 

    Animal Models:
         1 MGI phenotypic allele for Arl1 (no phenotypes)

    ARL1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/115 Interacting proteins for ARL1 (P406163 ENSP000002616364) via UniProtKB, MINT, STRING, and/or I2D (see all 115)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GOLGA1Q928053, ENSP000003626564I2D: score=3 STRING: ENSP00000362656
    GOLGA4Q134393, ENSP000003544864I2D: score=3 STRING: ENSP00000354486
    MYCP011063, ENSP000003672074I2D: score=3 STRING: ENSP00000367207
    ARFIP2P533653, ENSP000002545844I2D: score=1 STRING: ENSP00000254584
    C20orf24Q9BUV83, ENSP000003412134I2D: score=1 STRING: ENSP00000341213
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006184GTP catabolic process IDA8798635
    GO:0007030Golgi organization ISS--
    GO:0007264small GTPase mediated signal transduction IEA--
    GO:0009404toxin metabolic process IDA9624189
    GO:0031584activation of phospholipase D activity IDA9624189


    ARL1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARL1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARL1

    1 DrugBank Compound for ARL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Guanosine-5'-Diphosphate-- 146-91-8target--10592235

    1 Novoseek chemical compound relationship for ARL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 33.6 2 9388248 (1)

    Search CenterWatch for drugs/clinical trials and news about ARL1 

    Transcripts
    for ARL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARL1 gene: 
    NM_001177.4  

    Unigene Cluster for ARL1:

    ADP-ribosylation factor-like 1
    Hs.372616  [show with all ESTs]
    Unigene Representative Sequence: NM_001177
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261636(uc001tib.3 uc010svn.2 uc010svo.2) ENST00000539055
    ENST00000536227 ENST00000551688 ENST00000550597 ENST00000551828 ENST00000551671
    ENST00000551092 ENST00000549283 ENST00000549302 ENST00000548070

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ARL1
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARL1
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate ARL1 (see all 44):
    hsa-miR-323-3p hsa-miR-579 hsa-miR-300 hsa-miR-106a hsa-miR-548k hsa-miR-519a hsa-miR-9 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmid: ARL1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL1 (see all 7)
    OriGene shRNA RFP: ARL1
    OriGene siRNA: ARL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL1
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL1 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL1
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARL1 (NM_001177)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL1 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL1

    Additional cDNA sequence: 

    AF493887.1 AK001489.1 AK299062.1 AK301701.1 AK302911.1 AK311793.1 BC007000.1 BT007260.1 
    BX537387.1 L28997.1 

    14 DOTS entries:

    DT.444264  DT.100711542  DT.100811226  DT.121110841  DT.412382  DT.86851451  DT.121110832  DT.91767595 
    DT.100811228  DT.121110804  DT.121110809  DT.91767593  DT.92419699  DT.97767329 

    24/341 AceView cDNA sequences (see all 341):

    AL701988 AI475944 AA235859 CA411869 BU172367 BU627392 AI093193 AA455083 
    CR599734 BF940262 AW496789 AI346472 BF058308 AF493887 AI092621 CK299807 
    CA773352 CA488707 BM770539 BP342097 CA773423 CK725138 CA773568 AI360390 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ARL1 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:                                      -                 -                     
    SP2:                    -     -           -                                       
    SP3:                                      -                                       
    SP4:                    -     -     -     -                                       
    SP5:                    -     -     -     -     -           -                     


    ECgene alternative splicing isoforms for ARL1

    Expression
    for ARL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCAAATCTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemMesonephrosMesonephric cellsReproductive System
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARL1

    SOURCE GeneReport for Unigene cluster: Hs.372616

    UniProtKB/Swiss-Prot: ARL1_HUMAN, P40616
    Tissue specificity: Detected in heart, liver, lung and liver (at protein level). Detected in fetal heart, lung, liver
    and kidney. Detected in adult heart, placenta, lung, liver, skeletal muscle, kidney and pancreas

        SABiosciences Custom PCR Arrays for ARL1
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL1
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARL1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL1
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL1

    Orthologs
    for ARL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARL1 gene from 9/36 species (see all 36)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARL11 ADP-ribosylation factor-like 1 82.5(n)
    96.13(a)    		   417934  NM_001081494.1  NP_001074963.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARL16
    		 --
    		 97(a)
    		 1 ↔ 1
    		 5(28219783-28222060)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.240802 Xenopus laevis transcribed sequence with strong similarity more 82.37(n)    BJ058168.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.285532 Transcribed sequence with strong similarity to protein more 79.26(n)    CK354300.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Arf72A1 , 3 protein amino acid ADP-ribosylation GTP
    binding3
    Arflike at 72A1    		 77(a)3
    65.37(n)1
    78.89(a)1    		   72C13
    397451  NM_079374.31  NP_524098.21 
    worm
    (Caenorhabditis elegans)    		 Secernentea arl-11 , 3 GTP-binding ADP-ribosylation factor3
    Protein ARL-11    		 71(a)
    (best of 3)3
    63.7(n)1
    72.22(a)1    		   II(8581835-8582638)3
    1743751  NM_063415.51  NP_495816.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes ARL1(YBR164C)4
    ARL11    		 Soluble GTPase with a role in regulation of membrane more4
    Arl1p1    		 61.88(n)1
    64.09(a)1    		   2(568426-567875)4
    8524621, 4  NP_009723.31  NP_009723.14 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ARF31 ADP-ribosylation factor 3 62.38(n)
    65.36(a)    		   817014  NM_179726.2  NP_850057.1 
    rice
    (Oryza sativa)    		 Liliopsida Os08g02489001 hypothetical protein 61.11(n)
    64.44(a)    		   4345072  NM_001067903.1  NP_001061368.1 


    ENSEMBL Gene Tree for ARL1 (if available)
    TreeFam Gene Tree for ARL1 (if available) 

    Paralogs
    for ARL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARL1 gene
    ARL5B2  ARL162  ARL5C2  ARL62  ARL5A2  
    18/30 SIMAP similar genes for ARL1 using alignment to 7 protein entries:     ARL1_HUMAN (see all proteins) (see all similar genes):
    ARF3    ARL17A    ARL17B    ARF1    ARF5    ARF6
    ARF4    ARL3    ARL5B    ARL5A    ARL6    ARL14
    ARL2    ARL4A    ARL7    ARL8A    ARL8B    ARL10

    ARL1 for paralogs           About GeneDecksing



    Genomic Variants
    for ARL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/249 NCBI SNPs in ARL1 are shown (see all 249)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1929793241,2
    		--101786504(+) GCCAGA/GAGAAT 1 -- ds50010--------
    rs285324451,2
    		--101786511(+) GAATCA/GCTTGC 1 -- ds50010--------
    rs286881581,2
    		--101786605(+) AAAAAA/CAAAAA 1 -- ds50010--------
    rs2001948761,2
    		C--101786618(-) CTTTTG/TTTTTT 1 -- ds50010--------
    rs756727011,2
    		F,--101786745(+) ATTCTC/TACGCT 1 -- ds50011Minor allele frequency- T:0.06WA 118
    rs1874259361,2
    		--101786810(+) TTAATC/TCTAAG 1 -- ds50010--------
    rs1921718391,2
    		C,--101787049(+) GTGCAC/TCTCAG 1 -- ut310--------
    rs1847596121,2
    		--101787064(+) TTCAGA/TTAACA 1 -- ut310--------
    rs133871,2
    		C,F,--101787091(-) AAAATT/ATGAGA 1 -- ut314Minor allele frequency- A:0.04MN WA CSA 306
    rs1896206361,2
    		--101787137(+) AGAGTC/TATAAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for ARL1 (101786898 - 101801598 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARL1: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL1
    DNA2.0 Custom Variant and Variant Library Synthesis for ARL1

    Disorders / Diseases
    for ARL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARL1 for disorders           About GeneDecksing

    OMIM gene information: 603425    OMIM disorders: --

    3 diseases for ARL1:    About MalaCards
    cholera    melanoma    malaria

    1 Novoseek disease relationship for ARL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cholera 55 3 7814376 (2)


    Export disorders for ARL1 gene to outside databases

    Publications
    for ARL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARL1 gene, integrated from 9 sources (see all 44):
    (articles sorted by number of sources associating them with ARL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. ADP-ribosylation factors (ARFs) and ARF-like 1 (ARL1) have both specific and shared effectors: characterizing ARL1-binding proteins. (PubMed id 11303027)1, 2, 9 Van Valkenburgh H.... Kahn R.A. (2001)
    2. Different ARF domains are required for the activation of cholera toxin and phospholipase D. (PubMed id 7814376)1, 2, 9 Zhang G.-F.... Vaughan M. (1995)
    3. Phospholipid- and GTP-dependent activation of cholera toxin and phospholipase D by human ADP-ribosylation factor-like protein 1 (HARL1). (PubMed id 9624189)1, 2, 9 Hong J.X....Vaughan M. (1998)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Structural basis for Arl1-dependent targeting of homodimeric GRIP domains to the Golgi apparatus. (PubMed id 14580338)1, 2 Panic B....Munro S. (2003)
    7. Autoantigen Golgin-97, an effector of Arl1 GTPase, participates in traffic from the endosome to the trans-golgi network. (PubMed id 15269279)1, 9 Lu L....Hong W. (2004)
    8. Structural basis for membrane binding specificity of t he Bin/Amphiphysin/Rvs (BAR) domain of Arfaptin-2 determined by Arl1 GTPase. (PubMed id 22679020)1 Nakamura K....Wakatsuki S. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)

    External Searches for ARL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ARL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 400 HGNC: 692 AceView: ARL1 Ensembl:ENSG00000120805 euGenes: HUgn400
    ECgene: ARL1 H-InvDB: ARL1

    Other Databases showing ARL1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARL1 gene:
    Search GeneIP for patents involving ARL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ARL1 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ARL1  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARL1   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARL1  
     OriGene Protein Over-expression Lysate for ARL1   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ARL1   OriGene 3'-UTR Clone for ARL1  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARL1   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARL1  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     OriGene Purified Protein for ARL1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARL1   OriGene Custom Protein Services for ARL1  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARL1
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARL1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARL1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARL1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARL1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARL1
     GenScript Custom Purified and Recombinant Proteins Services for ARL1 GenScript cDNA clones with any tag delivered in your preferred vector for ARL1
     GenScript Custom Assay Services for ARL1 GenScript Custom Superior Antibodies Services for ARL1
     GenScript Custom overexpressing Cell Line Services for ARL1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARL1 promoter
     Search Chromatin IP Primers for ARL1
     RT2 qPCR Primer Assay in human, mouse, rat ARL1
     GNC Network for ARL1
     SABiosciences Custom PCR Arrays for ARL1
     Search Tocris compounds for ARL1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARL1 antibodies
     ARL1 proteins
     ARL1 lysates
     Antibodies for ARL1
     See all of Abcam's Antibodies, Kits and Proteins for ARL1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for ARL1




     ARL1 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ARL1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARL1
     SwitchGear 3'UTR luciferase reporter plasmids for ARL1
     SwitchGear Promoter luciferase reporter plasmids for ARL1
     ThermoFisher Antibodies for ARL1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARL1
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ARL1 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4