Aliases for ARL1 Gene
External Ids for ARL1 Gene
Previous GeneCards Identifiers for ARL1 Gene
The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]
GeneCards Summary for ARL1 Gene
ARL1 (ADP Ribosylation Factor Like GTPase 1) is a Protein Coding gene. Diseases associated with ARL1 include Cholera and Chylomicron Retention Disease. Among its related pathways are Vesicle-mediated transport and Retrograde transport at the Trans-Golgi-Network. GO annotations related to this gene include GTP binding and signal transducer activity. An important paralog of this gene is ARL8A.
UniProtKB/Swiss-Prot for ARL1 Gene
GTP-binding protein that has very low efficiency as allosteric activator of the cholera toxin catalytic subunit, an ADP-ribosyltransferase. Can activate phospholipase D with very low efficiency. Important for normal function of the Golgi apparatus.