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Aliases for ARIH2OS Gene

Aliases for ARIH2OS Gene

  • Ariadne RBR E3 Ubiquitin Protein Ligase 2 Opposite Strand 2 3
  • Ariadne Homolog 2 Opposite Strand 2 3 5
  • Ariadne-2 Homolog Opposite Strand Protein 3 4
  • C3orf71 3 4
  • Chromosome 3 Open Reading Frame 71 2
  • Uncharacterized Protein ARIH2OS 3

External Ids for ARIH2OS Gene

Previous HGNC Symbols for ARIH2OS Gene

  • C3orf71

Summaries for ARIH2OS Gene

GeneCards Summary for ARIH2OS Gene

ARIH2OS (Ariadne RBR E3 Ubiquitin Protein Ligase 2 Opposite Strand) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARIH2OS Gene

Genomics for ARIH2OS Gene

Regulatory Elements for ARIH2OS Gene

Enhancers for ARIH2OS Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G049016 1.4 ENCODE dbSUPER 11.2 -100.9 -100876 6.8 CREB3L1 AGO1 ZFP64 FEZF1 YY1 ZNF143 SP3 NFYC ZFP41 ZNF610 WDR6 AMT ENSG00000223343 QRICH1 CCDC71 P4HTM ENSG00000235236 ARIH2 QARS ARIH2OS
GH03G048896 1.1 ENCODE 13 +21.1 21098 3.2 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 WDR6 QRICH1 NME6 MRPS18AP1 ZNF589 ARIH2 ARIH2OS RHOA-IT1 CCDC71 TMEM89
GH03G048500 1.1 ENCODE dbSUPER 11.1 +416.3 416334 5.0 ZFP64 NFXL1 ZBTB40 ZNF121 GLIS2 EGR1 SCRT2 FOS SMARCA5 ZNF263 SHISA5 ARIH2OS CCDC36 PIR48300 GC03M048464
GH03G048543 1.1 Ensembl ENCODE dbSUPER 11.1 +375.9 375906 1.0 POLR2A GLIS1 ZNF624 REST ZBTB7A RBFOX2 UCN2 COL7A1 SHISA5 ATRIP TMA7 CCDC51 ENSG00000244380 ARIH2OS FBXW12 CDC25A
GH03G048952 0.9 FANTOM5 12.3 -33.4 -33448 0.1 HDGF ARID4B SIN3A BMI1 RAD21 YY1 ZNF335 IKZF2 BCLAF1 GATAD2B ARIH2 ARIH2OS ENSG00000235236 P4HTM ENSG00000223343 LAMB2 QARS USP4 PIR60921 PIR40585
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARIH2OS on UCSC Golden Path with GeneCards custom track

Promoters for ARIH2OS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000152164 185 2401 HDGF PKNOX1 FOXA2 CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF207 SP3

Genomic Location for ARIH2OS Gene

Chromosome:
3
Start:
48,917,788 bp from pter
End:
48,919,385 bp from pter
Size:
1,598 bases
Orientation:
Minus strand

Genomic View for ARIH2OS Gene

Genes around ARIH2OS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARIH2OS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARIH2OS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARIH2OS Gene

Proteins for ARIH2OS Gene

  • Protein details for ARIH2OS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7S6-ARI2O_HUMAN
    Recommended name:
    Uncharacterized protein ARIH2OS
    Protein Accession:
    Q8N7S6

    Protein attributes for ARIH2OS Gene

    Size:
    290 amino acids
    Molecular mass:
    30424 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARIH2OS Gene

Post-translational modifications for ARIH2OS Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARIH2OS Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARIH2OS Gene

Domains & Families for ARIH2OS Gene

Protein Domains for ARIH2OS Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARIH2OS: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for ARIH2OS Gene

Function for ARIH2OS Gene

Phenotypes for ARIH2OS Gene

GenomeRNAi human phenotypes for ARIH2OS:
genes like me logo Genes that share phenotypes with ARIH2OS: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARIH2OS Gene

Localization for ARIH2OS Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARIH2OS Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARIH2OS gene
Compartment Confidence
plasma membrane 3
extracellular 2
nucleus 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ARIH2OS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with ARIH2OS: view

Pathways & Interactions for ARIH2OS Gene

SuperPathways for ARIH2OS Gene

No Data Available

Interacting Proteins for ARIH2OS Gene

Gene Ontology (GO) - Biological Process for ARIH2OS Gene

None

No data available for Pathways by source and SIGNOR curated interactions for ARIH2OS Gene

Drugs & Compounds for ARIH2OS Gene

No Compound Related Data Available

Transcripts for ARIH2OS Gene

mRNA/cDNA for ARIH2OS Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARIH2OS Gene

Ariadne homolog 2 opposite strand:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARIH2OS Gene

No ASD Table

Relevant External Links for ARIH2OS Gene

GeneLoc Exon Structure for
ARIH2OS
ECgene alternative splicing isoforms for
ARIH2OS

Expression for ARIH2OS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARIH2OS Gene

mRNA expression in normal human tissues for ARIH2OS Gene

Protein differential expression in normal tissues from HIPED for ARIH2OS Gene

This gene is overexpressed in Testis (45.2) and Ovary (19.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARIH2OS Gene



Protein tissue co-expression partners for ARIH2OS Gene

NURSA nuclear receptor signaling pathways regulating expression of ARIH2OS Gene:

ARIH2OS

SOURCE GeneReport for Unigene cluster for ARIH2OS Gene:

Hs.720727
genes like me logo Genes that share expression patterns with ARIH2OS: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARIH2OS Gene

Orthologs for ARIH2OS Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for ARIH2OS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARIH2OS 35
  • 98 (a)
OneToOne
Species where no ortholog for ARIH2OS was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for ARIH2OS Gene

ENSEMBL:
Gene Tree for ARIH2OS (if available)
TreeFam:
Gene Tree for ARIH2OS (if available)

Paralogs for ARIH2OS Gene

No data available for Paralogs for ARIH2OS Gene

Variants for ARIH2OS Gene

Sequence variations from dbSNP and Humsavar for ARIH2OS Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1000496894 -- 48,920,494(+) TTTCT(C/T)TTTTT intron-variant, upstream-variant-2KB
rs1001848175 -- 48,918,385(+) GTGAC(A/C)GTAAG upstream-variant-2KB, reference, synonymous-codon
rs1002965448 -- 48,920,477(+) GAGAA(C/G)CCTGT intron-variant, upstream-variant-2KB
rs1004405656 -- 48,917,809(+) ATTTT(A/T)TTTTA upstream-variant-2KB, utr-variant-3-prime
rs1005704111 -- 48,919,657(+) CCTGA(A/G)AAACT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARIH2OS Gene

Variant ID Type Subtype PubMed ID
esv3893694 CNV loss 25118596

Variation tolerance for ARIH2OS Gene

Residual Variation Intolerance Score: 58.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.40; 27.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARIH2OS Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARIH2OS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARIH2OS Gene

Disorders for ARIH2OS Gene

Relevant External Links for ARIH2OS

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARIH2OS

No disorders were found for ARIH2OS Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARIH2OS Gene

Publications for ARIH2OS Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4 64

Products for ARIH2OS Gene

Sources for ARIH2OS Gene

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