Aliases for ARIH2 Gene
External Ids for ARIH2 Gene
Previous GeneCards Identifiers for ARIH2 Gene
The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
GeneCards Summary for ARIH2 Gene
ARIH2 (Ariadne RBR E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Among its related pathways are NF-kappaB Signaling and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include nucleic acid binding and ubiquitin-protein transferase activity. An important paralog of this gene is ANKIB1.
UniProtKB/Swiss-Prot for ARIH2 Gene
E3 ubiquitin-protein ligase mediating Lys-48-and Lys-63-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.