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Aliases for ARIH2 Gene

Aliases for ARIH2 Gene

  • Ariadne RBR E3 Ubiquitin Protein Ligase 2 2 3 5
  • All-Trans Retinoic Acid Inducible RING Finger 2 3
  • Protein Ariadne-2 Homolog 3 4
  • TRIAD1 3 4
  • ARI2 3 4
  • Ariadne (Drosophila) Homolog 2 2
  • Ariadne Homolog 2 (Drosophila) 2
  • Ariadne Homolog 2 3
  • Triad1 Protein 4
  • EC 6.3.2.- 4
  • ARI-2 4

External Ids for ARIH2 Gene

Previous GeneCards Identifiers for ARIH2 Gene

  • GC03U990111
  • GC03P048231
  • GC03P048810
  • GC03P048915

Summaries for ARIH2 Gene

Entrez Gene Summary for ARIH2 Gene

  • The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]

GeneCards Summary for ARIH2 Gene

ARIH2 (Ariadne RBR E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. GO annotations related to this gene include nucleic acid binding and ubiquitin-protein transferase activity. An important paralog of this gene is ANKIB1.

UniProtKB/Swiss-Prot for ARIH2 Gene

  • E3 ubiquitin-protein ligase mediating Lys-48-and Lys-63-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.

Gene Wiki entry for ARIH2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARIH2 Gene

Genomics for ARIH2 Gene

Regulatory Elements for ARIH2 Gene

Promoters for ARIH2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARIH2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARIH2 Gene

Chromosome:
3
Start:
48,918,821 bp from pter
End:
48,986,382 bp from pter
Size:
67,562 bases
Orientation:
Plus strand

Genomic View for ARIH2 Gene

Genes around ARIH2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARIH2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARIH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARIH2 Gene

Proteins for ARIH2 Gene

  • Protein details for ARIH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95376-ARI2_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ARIH2
    Protein Accession:
    O95376
    Secondary Accessions:
    • Q9HBZ6
    • Q9UEM9

    Protein attributes for ARIH2 Gene

    Size:
    493 amino acids
    Molecular mass:
    57819 Da
    Quaternary structure:
    • Interacts (via RING-type 1) with UBE2L3. Interacts (via RING-type 2) with UBE2N. Interacts (via RING-type 2) with GFI1B. Interacts with GFI1; prevents its ubiquitination and proteasomal degradation.
    SequenceCaution:
    • Sequence=AAG09696.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for ARIH2 Gene

Proteomics data for ARIH2 Gene at MOPED

Post-translational modifications for ARIH2 Gene

  • Ubiquitinated. Ubiquitination promotes proteasomal degradation.
  • Ubiquitination at Lys 364, Lys 377, and Lys 460
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ARIH2 (ARIH2)

No data available for DME Specific Peptides for ARIH2 Gene

Domains & Families for ARIH2 Gene

Suggested Antigen Peptide Sequences for ARIH2 Gene

Graphical View of Domain Structure for InterPro Entry

O95376

UniProtKB/Swiss-Prot:

ARI2_HUMAN :
  • RING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis.
  • Belongs to the RBR family. Ariadne subfamily.
  • Contains 1 IBR-type zinc finger.
Domain:
  • RING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis.
Family:
  • Belongs to the RBR family. Ariadne subfamily.
Similarity:
  • Contains 1 IBR-type zinc finger.
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with ARIH2: view

No data available for Gene Families for ARIH2 Gene

Function for ARIH2 Gene

Molecular function for ARIH2 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase mediating Lys-48-and Lys-63-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.
UniProtKB/Swiss-Prot Induction:
Up-regulated by all-trans retinoic acid (ATRA). Up-regulated during differentiation of immature blood cells toward monocytes and granulocytes.

Enzyme Numbers (IUBMB) for ARIH2 Gene

Gene Ontology (GO) - Molecular Function for ARIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA,IDA 16118314
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with ARIH2: view
genes like me logo Genes that share phenotypes with ARIH2: view

Animal Models for ARIH2 Gene

MGI Knock Outs for ARIH2:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARIH2 Gene

Localization for ARIH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARIH2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARIH2 Gene COMPARTMENTS Subcellular localization image for ARIH2 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ARIH2 Gene

Pathways & Interactions for ARIH2 Gene

genes like me logo Genes that share pathways with ARIH2: view

UniProtKB/Swiss-Prot O95376-ARI2_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for ARIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development TAS 10422847
GO:0016567 protein ubiquitination IEA --
GO:0071425 hematopoietic stem cell proliferation IDA 16118314
GO:1903955 positive regulation of protein targeting to mitochondrion IMP 24270810
genes like me logo Genes that share ontologies with ARIH2: view

No data available for SIGNOR curated interactions for ARIH2 Gene

Drugs & Compounds for ARIH2 Gene

No Compound Related Data Available

Transcripts for ARIH2 Gene

Unigene Clusters for ARIH2 Gene

Ariadne homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARIH2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
SP1:
SP2: -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for ARIH2 Gene

GeneLoc Exon Structure for
ARIH2
ECgene alternative splicing isoforms for
ARIH2

Expression for ARIH2 Gene

mRNA expression in normal human tissues for ARIH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARIH2 Gene

This gene is overexpressed in Lung (24.1) and Peripheral blood mononuclear cells (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARIH2 Gene



SOURCE GeneReport for Unigene cluster for ARIH2 Gene Hs.633601

mRNA Expression by UniProt/SwissProt for ARIH2 Gene

O95376-ARI2_HUMAN
Tissue specificity: Widely expressed with higher expression in granulocytes.
genes like me logo Genes that share expression patterns with ARIH2: view

Protein tissue co-expression partners for ARIH2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARIH2 Gene

Orthologs for ARIH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARIH2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARIH2 35
  • 93.01 (n)
  • 98.17 (a)
ARIH2 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARIH2 35
  • 94.37 (n)
  • 98.57 (a)
ARIH2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arih2 35
  • 91.67 (n)
  • 98.17 (a)
Arih2 16
Arih2 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARIH2 35
  • 99.59 (n)
  • 99.59 (a)
ARIH2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arih2 35
  • 91.87 (n)
  • 98.37 (a)
oppossum
(Monodelphis domestica)
Mammalia ARIH2 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARIH2 36
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARIH2 35
  • 84.22 (n)
  • 93.67 (a)
ARIH2 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARIH2 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arih2 35
  • 81.33 (n)
  • 92.67 (a)
Str.746 35
African clawed frog
(Xenopus laevis)
Amphibia MGC68617 35
zebrafish
(Danio rerio)
Actinopterygii arih2 35
  • 76.65 (n)
  • 82.23 (a)
Dr.25750 35
arih2 36
  • 81 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8799 35
fruit fly
(Drosophila melanogaster)
Insecta ari-2 37
  • 55 (a)
ari-2 35
  • 60.58 (n)
  • 58.48 (a)
ari-2 36
  • 53 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005977 35
  • 61.04 (n)
  • 59.74 (a)
worm
(Caenorhabditis elegans)
Secernentea T12E12.1 37
  • 47 (a)
T12E12.1 35
  • 52.28 (n)
  • 49.34 (a)
T12E12.1 36
  • 46 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 23 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os08g0540300 35
  • 44.58 (n)
  • 30.54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1806 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 55 (a)
OneToOne
Species with no ortholog for ARIH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARIH2 Gene

ENSEMBL:
Gene Tree for ARIH2 (if available)
TreeFam:
Gene Tree for ARIH2 (if available)

Paralogs for ARIH2 Gene

Paralogs for ARIH2 Gene

(1) SIMAP similar genes for ARIH2 Gene using alignment to 7 proteins:

Pseudogenes.org Pseudogenes for ARIH2 Gene

genes like me logo Genes that share paralogs with ARIH2: view

Variants for ARIH2 Gene

Sequence variations from dbSNP and Humsavar for ARIH2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs11507 - 48,927,628(+) aggaa(A/G)aggaa intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs34221642 - 48,927,645(+) GAAGA(A/C)GACGA intron-variant, nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1134591 -- 48,935,459(+) CCTAT(A/G)TATTA intron-variant
rs3202411 -- 48,938,759(+) TCATT(A/C)CAAAA intron-variant
rs5848862 -- 48,938,064(+) AAAAA(-/AA)ATGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARIH2 Gene

Variant ID Type Subtype PubMed ID
esv2473053 CNV Deletion 19546169
esv2725249 CNV Deletion 23290073

Variation tolerance for ARIH2 Gene

Residual Variation Intolerance Score: 15.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.36; 8.00% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARIH2 Gene

HapMap Linkage Disequilibrium report
ARIH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARIH2 Gene

Disorders for ARIH2 Gene

Relevant External Links for ARIH2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARIH2

No disorders were found for ARIH2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARIH2 Gene

Publications for ARIH2 Gene

  1. TRIADs: a new class of proteins with a novel cysteine-rich signature. (PMID: 10422847) van der Reijden B.A. … Jansen J.H. (Protein Sci. 1999) 2 3 4 67
  2. Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase. (PMID: 24058416) Spratt D.E. … Shaw G.S. (PLoS ONE 2013) 2 3
  3. The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains. (PMID: 19340006) Marteijn J.A. … van der Reijden B.A. (Leukemia 2009) 3 23
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for ARIH2 Gene

Sources for ARIH2 Gene

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