Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARIH2 Gene

protein-coding   GIFtS: 59
GCID: GC03P048931

Ariadne RBR E3 Ubiquitin Protein Ligase 2

(Previous names: ariadne (Drosophila) homolog 2, ariadne homolog 2 (Drosophila))
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Ariadne RBR E3 Ubiquitin Protein Ligase 21     ARI-22 3
ARI22 3 5     Ariadne (Drosophila) Homolog 21
TRIAD12 3 5     E3 Ubiquitin-Protein Ligase ARIH22
Ariadne Homolog 2 (Drosophila)1 2     EC 6.3.2.-3
All-Trans Retinoic Acid Inducible RING Finger1 2     Triad1 Protein3
Protein Ariadne-2 Homolog2 3     

External Ids:    HGNC: 6901   Entrez Gene: 104252   Ensembl: ENSG000001774797   OMIM: 6056155   UniProtKB: O953763   

Export aliases for ARIH2 gene to outside databases

Previous GC identifers: GC03U990111 GC03P048231 GC03P048810 GC03P048915


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for ARIH2 Gene: 
ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2) is a protein-coding gene. Diseases associated with ARIH2 include schizophrenia, and among its related super-pathways are Class I MHC mediated antigen processing & presentation and Immune System. GO annotations related to this gene include ubiquitin-protein ligase activity and nucleic acid binding. An important paralog of this gene is ANKIB1.

UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent
proteasomal degradation of modified proteins. May play a role in myelopoiesis

Gene Wiki entry for ARIH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NT_022517.18  NC_018914.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARIH2 gene promoter:
         Nkx3-1   AhR   Elk-1   Pax-5   Nkx3-1 v1   Arnt   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARIH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARIH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARIH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

ARIH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARIH2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P048931:  view genomic region     (about GC identifiers)

Start:
48,956,254 bp from pter      End:
49,023,815 bp from pter
Size:
67,562 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ARIH2  
Size: 493 amino acids; 57819 Da
Subunit: Interacts (via RING-type 1) with UBE2L3. Interacts (via RING-type 2) with UBE2N. Interacts (via RING-type
2) with GFI1B. Interacts with GFI1; prevents its ubiquitination and proteasomal degradation
Subcellular location: Nucleus. Cytoplasm
Sequence caution: Sequence=AAG09696.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q9HBZ6 Q9UEM9

Explore the universe of human proteins at neXtProt for ARIH2: NX_O95376

Explore proteomics data for ARIH2 at MOPED 

Post-translational modifications:

  • UniProtKB: Ubiquitinated. Ubiquitination promotes proteasomal degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O95376

  • ARIH2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARIH2 Protein Expression
    REFSEQ proteins: NP_006312.1  
    ENSEMBL proteins: 
     ENSP00000395560   ENSP00000399788   ENSP00000348769   ENSP00000403222   ENSP00000397225  
     ENSP00000404838   ENSP00000406063   ENSP00000403845  
    Reactome Protein details: O95376
    Human Recombinant Protein Products for ARIH2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ARIH2
    OriGene Protein Over-expression Lysate for ARIH2
    OriGene MassSpec for ARIH2 
    OriGene Custom Protein Services for ARIH2
    GenScript Custom Purified and Recombinant Proteins Services for ARIH2
    Novus Biologicals ARIH2 Proteins
    Novus Biologicals ARIH2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARIH2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16118314
    GO:0005737cytoplasm IDA19340006

    ARIH2 for ontologies           About GeneDecksing



    ARIH2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ARIH2
    OriGene Custom Antibody Services for ARIH2
    GenScript Custom Superior Antibodies Services for ARIH2
    Novus Biologicals ARIH2 Antibodies
    Abcam antibodies for ARIH2
    Cloud-Clone Corp. Antibodies for ARIH2 
    ThermoFisher Antibody for ARIH2
    LSBio Antibodies in human, mouse, rat for ARIH2 

    Assay Products for ARIH2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARIH2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARIH2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARIH2 
    Cloud-Clone Corp. CLIAs for ARIH2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR002867 Znf_C6HC
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry O95376

    ProtoNet protein and cluster: O95376

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB002867 Zn-finger


    UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
    Domain: RING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis
    Similarity: Belongs to the RBR family. Ariadne subfamily
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers


    ARIH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARI2_HUMAN, O95376
    Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent
    proteasomal degradation of modified proteins. May play a role in myelopoiesis
    Induction: Up-regulated by all-trans retinoic acid (ATRA). Up-regulated during differentiation of immature blood
    cells toward monocytes and granulocytes

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA16118314
    GO:0005515protein binding IPI16118314
    GO:0008270zinc ion binding IEA--
         
    ARIH2 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arih2):
     cardiovascular system  cellular  growth/size  immune system  integument 
     liver/biliary system  mortality/aging  respiratory system 

    ARIH2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arih2tm1Mak for ARIH2

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARIH2 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARIH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARIH2 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARIH2 

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARIH2:
    hsa-mir-19a (MIRT005396)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARIH2
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ARIH2 (see all 39):
    hsa-miR-596 hsa-miR-3152-3p hsa-miR-642a hsa-miR-429 hsa-let-7a-2* hsa-miR-488 hsa-miR-570 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidARIH2 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARIH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARIH2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARIH2
    Sirion Biotech Customized adenovirus for overexpression of ARIH2

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ARIH2 (see all 7)
    OriGene ORF clones in mouse, rat for ARIH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARIH2 (NM_006321)
    Sino Biological Human cDNA Clone for ARIH2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARIH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARIH2
    Sirion Biotech Customized lentivirus for stable overexpression of ARIH2 
                         Customized lentivirus expression plasmids for stable overexpression of ARIH2 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARIH2
    Search LifeMap BioReagents cell lines for ARIH2
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARIH2


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARIH2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Antigen processing: Ubiquitination & Proteasome degradation
    Antigen processing: Ubiquitination & Proteasome degradation0.83
    Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    Immune System0.56
    Adaptive Immune System0.56

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    4        Reactome Pathways for ARIH2
        Antigen processing: Ubiquitination & Proteasome degradation
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
    Pathway: Protein modification; protein ubiquitination


    ARIH2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARIH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for ARIH2 (O953761, 2, 3 ENSP000003487694) via UniProtKB, MINT, STRING, and/or I2D (see all 70)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-8385595 MINT-8385459 MINT-8385531 MINT-8385886 MINT-8385510 MINT-63290 I2D: score=5 STRING: ENSP00000269305
    ARAP1Q96P482, 3MINT-63305 I2D: score=5 
    CBR3O758282, 3MINT-63289 I2D: score=5 
    EEF1GP266412, 3MINT-63293 I2D: score=5 
    ENSAO437682, 3MINT-63298 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA16118314
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0007275multicellular organismal development TAS10422847
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA16118314
    GO:0048588developmental cell growth IDA19340006

    ARIH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARIH2 (ARI2)

    Search CenterWatch for drugs/clinical trials and news about ARIH2 / ARI2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARIH2 gene: 
    NM_006321.2  

    Unigene Cluster for ARIH2:

    Ariadne homolog 2 (Drosophila)
    Hs.633601  [show with all ESTs]
    Unigene Representative Sequence: NM_006321
    18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000452882 ENST00000430423(uc003cve.1) ENST00000478224 ENST00000356401(uc003cvb.3 uc003cvc.3 uc003cvf.3 uc010hkl.3)
    ENST00000498314 ENST00000474618 ENST00000492077 ENST00000463738 ENST00000490095
    ENST00000449376 ENST00000495761 ENST00000482427 ENST00000483333 ENST00000488963
    ENST00000420814 ENST00000486316 ENST00000449729 ENST00000433170
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARIH2
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ARIH2 (see all 39):
    hsa-miR-596 hsa-miR-3152-3p hsa-miR-642a hsa-miR-429 hsa-let-7a-2* hsa-miR-488 hsa-miR-570 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidARIH2 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARIH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARIH2
    Clone
    Products:
         
    OriGene clones in human, mouse for ARIH2 (see all 7)
    OriGene ORF clones in mouse, rat for ARIH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARIH2 (NM_006321)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARIH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARIH2
    Sirion Biotech Customized lentivirus for stable overexpression of ARIH2 
                         Customized lentivirus expression plasmids for stable overexpression of ARIH2 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARIH2
    OriGene qSTAR qPCR primer pairs in human, mouse for ARIH2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARIH2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARIH2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARIH2

    Additional mRNA sequence: 

    AB208857.1 AF099149.1 AF099150.1 AF099151.1 AF099152.1 AF099153.1 AF113677.1 AF183427.1 
    AJ130978.1 AK001800.1 AK091240.1 AK223550.1 AK307694.1 AK313434.1 AL110187.1 AL162034.1 
    BC000422.2 CR456785.1 

    24/48 DOTS entries (see all 48):

    DT.80100977  DT.100823541  DT.91836598  DT.95163707  DT.95163712  DT.120852490  DT.120852559  DT.120852584 
    DT.95082829  DT.100810548  DT.100823539  DT.120852458  DT.97782866  DT.100823538  DT.120852519  DT.95163715 
    DT.120852484  DT.75196705  DT.120852557  DT.120852627  DT.120852630  DT.91759032  DT.97861022  DT.100823542 

    24/417 AceView cDNA sequences (see all 417):

    CD673554 BQ005221 BM928477 AI292192 BM703364 BE250241 AA729927 AW514268 
    AI679456 BF476220 T31128 AU126005 NM_006321 BQ026735 CF594094 W74365 
    F24192 BQ189323 BE044105 AA576974 AF113677 BM984227 BU181342 BM991659 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ARIH2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                                                                                  
    SP2:                                                                                -                                 
    SP3:        -     -                                                                                                   
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ARIH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARIH2 expression in normal human tissues (normalized intensities)      ARIH2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAACTGGC
    ARIH2 Expression
    About this image


    ARIH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/4 selected tissues (see all 4) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             gastrocnemius muscle   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
             stem cells (umbilical cord cd34+)   
     
     Heart (Cardiovascular System)
             left ventricular apex samples   
     
     Umbilical Cord (Extraembryonic Tissues)
             stem cells (umbilical cord cd34+)   

     -- (Muscoskeletal System)
             muscle   

    See ARIH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARIH2

    SOURCE GeneReport for Unigene cluster: Hs.633601

    UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
    Tissue specificity: Widely expressed with higher expression in granulocytes

        SABiosciences Expression via Pathway-Focused PCR Array including ARIH2: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARIH2
    OriGene qSTAR qPCR primer pairs in human, mouse for ARIH2
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARIH2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARIH2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARIH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARIH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARIH2 gene from 9/20 species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arih21 , 5 ariadne homolog 2 (Drosophila)1, 5 91.67(n)1
    98.37(a)1
      9 (59.54 cM)5
    238071  NM_011790.41  NP_035920.11 
     1086029425 
    chicken
    (Gallus gallus)
    Aves ARIH21 ariadne homolog 2 (Drosophila) 84.22(n)
    93.88(a)
      416061  NM_001199221.1  NP_001186150.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARIH26
    ariadne homolog 2 (Drosophila)
    93(a)
    1 ↔ 1
    2(187720334-187751602)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686172 hypothetical protein MGC68617 80.01(n)    BC061943.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.257502 Danio rerio cDNA clone MGC64093 IMAGE6794947, complete more 77.16(n)    BC053248.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ari-21 , 3 ubiquitin-protein ligase3
    ariadne 21
    55(a)3
    59.99(n)1
    57.17(a)1
      58D23
    375421  NM_058026.31  NP_477374.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T12E12.11 , 3 Protein T12E12.11 47(a)3
    52.06(n)1
    48.3(a)1
      IV(5551336-5558586)3
    1773391  NM_068428.41  NP_500829.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes YKR017C6
    Putative protein of unknown function; contains a R...
    23(a)
    1 → many
    XI(471694-473349)
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARI91 putative E3 ubiquitin-protein ligase ARI9 42.99(n)
    30.61(a)
      817734  NM_128735.1  NP_180736.1 


    ENSEMBL Gene Tree for ARIH2 (if available)
    TreeFam Gene Tree for ARIH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARIH2 gene
    ANKIB12  ARIH12  
    1 SIMAP similar gene for ARIH2 using alignment to 7 protein entries:     ARI2_HUMAN (see all proteins):
    ARIH1

    ARIH2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARIH2
    PGOHUM00000235034


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/972 SNPs in ARIH2 are shown (see all 972)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs600259361,2
    C,F--48954720(+) CTACAG/AGCGCC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1494441461,2
    --48958976(+) ATTCTC/TCTGCC 1 -- int10--------
    rs1448363291,2
    --48959017(+) ATGCGC/TCACCA 1 -- int10--------
    rs1876858441,2
    --48959043(+) TGTGTG/TTTTTG 1 -- int10--------
    rs1162775691,2
    F--48959073(+) TGTTGC/TCCAGG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1485696871,2
    --48959145(+) GGGATG/TACTGG 1 -- int10--------
    rs1429105091,2
    --48959149(+) TTACTA/GGCATG 1 -- int10--------
    rs1465978521,2
    --48959601(+) ACAGTA/GAGCTG 1 -- int10--------
    rs117089061,2
    H--48959644(+) agaggC/Gaggcc 1 -- int10--------
    rs1919893961,2
    --48959888(+) CTCGAA/TCTCCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for ARIH2 (48956254 - 49023815 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARIH2:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2473053CNV Deletion19546169
    esv2725249CNV Deletion23290073

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARIH2
    DNA2.0 Custom Variant and Variant Library Synthesis for ARIH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605615    OMIM disorders: --

    2 diseases for ARIH2:    About MalaCards
    schizophrenia    


    ARIH2 for disorders           About GeneDecksing


    Export disorders for ARIH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARIH2 gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with ARIH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRIADs: a new class of proteins with a novel cysteine-rich signature. (PubMed id 10422847)1, 2, 3 van der Reijden B.A....Jansen J.H. (1999)
    2. The ubiquitin ligase Triad1 inhibits myelopoiesis thr ough UbcH7 and Ubc13 interacting domains. (PubMed id 19340006)1, 2, 9 Marteijn J.A....van der Reijden B.A. (2009)
    3. Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1. (PubMed id 17646546)1, 2 Marteijn J.A....Van der Reijden B.A. (2007)
    4. The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells. (PubMed id 16118314)1, 2 Marteijn J.A....van der Reijden B.A. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    7. Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins. (PubMed id 10880484)1, 2 Aguilera M.... Ferrus A. (2000)
    8. VCP phosphorylation-dependent interaction partners pre vent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (2013)
    9. Structure of the HHARI Catalytic Domain Shows Glimpses of a HECT E3 Ligase. (PubMed id 24058416)3 Spratt D.E....Shaw G.S. (2013)
    10. TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation. (PubMed id 22819825)1 Bae S....An S. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10425 HGNC: 690 AceView: ARIH2 Ensembl:ENSG00000177479 euGenes: HUgn10425
    ECgene: ARIH2 H-InvDB: ARIH2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARIH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARIH2 gene:
    Search GeneIP for patents involving ARIH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ARIH2   OriGene RNAi products in human, mouse, rat for ARIH2  
     OriGene qPCR primer pairs and template standards for ARIH2   OriGene Protein Over-expression Lysate for ARIH2  
     OriGene MassSpec something-or-other for ARIH2   OriGene clones in human, mouse for ARIH2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARIH2   OriGene Purified Protein for ARIH2  
     OriGene ORF clones in mouse, rat for ARIH2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARIH2   OriGene Custom Protein Services for ARIH2  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARIH2
     QIAGEN SeqTarget long-range PCR primers for resequencing ARIH2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARIH2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARIH2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARIH2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARIH2
     GenScript Custom Purified and Recombinant Proteins Services for ARIH2 GenScript cDNA clones with any tag delivered in your preferred vector for ARIH2
     GenScript Custom Assay Services for ARIH2 GenScript Custom Superior Antibodies Services for ARIH2
     GenScript Custom overexpressing Cell Line Services for ARIH2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARIH2 promoter
     Search Chromatin IP Primers for ARIH2
     RT2 qPCR Primer Assay in human, mouse, rat ARIH2
     GNC Network for ARIH2
     SABiosciences PCR Arrays including human, mouse, rat ARIH2
     Search Tocris compounds for ARIH2 (ARI2)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for ARIH2
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARIH2 antibodies
     ARIH2 proteins
     ARIH2 lysates
     Antibodies for ARIH2
     See all of Abcam's Antibodies, Kits and Proteins for ARIH2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ARIH2
     Antibodies for ARIH2
     ELISAs for ARIH2
     CLIAs for ARIH2
     Search LifeMap BioReagents cell lines for ARIH2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARIH2
     SwitchGear 3'UTR luciferase reporter plasmids for ARIH2
     SwitchGear Promoter luciferase reporter plasmids for ARIH2
     ThermoFisher Antibody for ARIH2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARIH2
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ARIH2
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARIH2
    Customized:
     lentivirus for stable overexpression of ARIH2
     lentivirus expression plasmids for stable overexpression of ARIH2
     adenovirus for overexpression of ARIH2
     LSBio Antibodies in human, mouse, rat for ARIH2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARIH2 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4