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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARIH2 Gene

protein-coding   GIFtS: 57
GCID: GC03P048931

ariadne homolog 2 (Drosophila)

(Previous name: ariadne (Drosophila) homolog 2 )
 Explore 2 diseases affiliated with
ARIH2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARIH2    

Aliases
for ARIH2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ariadne Homolog 2 (Drosophila)1 2     Ariadne (Drosophila) Homolog 21
TRIAD11 2 3 5     All-Trans Retinoic Acid Inducible RING Finger2
ARI22 3 5     E3 Ubiquitin-Protein Ligase ARIH22
Protein Ariadne-2 Homolog2 3     EC 6.3.2.-3
ARI-22 3     Triad1 Protein3

External Ids:    HGNC: 6901   Entrez Gene: 104252   Ensembl: ENSG000001774797   OMIM: 6056155   UniProtKB: O953763   

Export aliases for ARIH2 gene to outside databases

Previous GC identifers: GC03U990111 GC03P048231 GC03P048810 GC03P048915


Summaries
for ARIH2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent
proteasomal degradation of modified proteins. May play a role in myelopoiesis

Gene Wiki entry for ARIH2


Genomic Views
for ARIH2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARIH2 gene promoter:
         Nkx3-1   AhR   Elk-1   Pax-5   Nkx3-1 v1   Arnt   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARIH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARIH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARIH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

ARIH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARIH2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P048931:  view genomic region     (about GC identifiers)

Start:
 48,956,254 bp from pter      End:
 49,023,815 bp from pter
Size:
 67,562 bases      Orientation:
 plus strand

Proteins
for ARIH2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ARIH2  
Size: 493 amino acids; 57819 Da
Subunit: Interacts (via RING-type 1) with UBE2L3. Interacts (via RING-type 2) with UBE2N. Interacts (via RING-type 2)
with GFI1B. Interacts with GFI1; prevents its ubiquitination and proteasomal degradation
Subcellular location: Nucleus. Cytoplasm
Sequence caution: Sequence=AAG09696.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q9HBZ6 Q9UEM9

Explore the universe of human proteins at neXtProt for ARIH2: NX_O95376

Post-translational modifications:

  • Ubiquitinated. Ubiquitination promotes proteasomal degradation1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_O95376

    • ARIH2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_006312.1  
    ENSEMBL proteins: 
     ENSP00000395560   ENSP00000399788   ENSP00000348769   ENSP00000403222   ENSP00000397225  
     ENSP00000404838   ENSP00000406063   ENSP00000403845  
    Reactome Protein details: O95376
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: ARIH2
    OriGene Protein Over-expression Lysate: ARIH2
    OriGene Custom Protein Services for ARIH2 
    GenScript Custom Purified and Recombinant Proteins Services for ARIH2
    Novus Biologicals ARIH2 Proteins
    Novus Biologicals ARIH2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ARIH2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16118314
    GO:0005737cytoplasm IDA19340006


    ARIH2 for ontologies           About GeneDecksing



    ARIH2 Antibody Products: 
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    Uscn Antibodies for ARIH2
    ThermoFisher Antibodies for ARIH2

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    Uscn ELISAs and CLIAs for ARIH2

    Protein Domains /
    Families
    for ARIH2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARIH2 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017907 Znf_RING_CS
     IPR002867 Znf_C6HC
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry O95376

    ProtoNet protein and cluster: O95376

    2 Blocks protein families:
    IPB001841 Zn-finger
    IPB002867 Zn-finger


    UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
    Domain: RING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis
    Similarity: Belongs to the RBR family. Ariadne subfamily
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers


    Function
    for ARIH2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
    Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent
    proteasomal degradation of modified proteins. May play a role in myelopoiesis
    Induction: Up-regulated by all-trans retinoic acid (ATRA). Up-regulated during differentiation of immature blood cells
    toward monocytes and granulocytes

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:            		miRTarBase miRNAs that target ARIH2:
    hsa-mir-19a (MIRT005396)

    OriGene 3'-UTR Clone: ARIH2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARIH2
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ARIH2 (see all 39):
    hsa-miR-596 hsa-miR-3152-3p hsa-miR-642a hsa-miR-429 hsa-let-7a-2* hsa-miR-488 hsa-miR-570 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmid: ARIH2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARIH2 (see all 7)
    OriGene shRNA RFP: ARIH2
    OriGene siRNA: ARIH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARIH2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARIH2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARIH2 (see all 3)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARIH2 (NM_006321)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARIH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARIH2 

    Cell Line
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    Search LifeMap BioReagents cell lines for ARIH2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARIH2

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA16118314
    GO:0005515protein binding IPI19549727
    GO:0008270zinc ion binding IEA--


    ARIH2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Arih2tm1Mak for ARIH2
         8 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Arih2):
     cardiovascular system  cellular  growth/size  immune system  integument 
     liver/biliary system  mortality/aging  respiratory system 

    ARIH2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARIH2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for ARIH2
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
    Pathway: Protein modification; protein ubiquitination


    ARIH2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARIH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for ARIH2 (O953761, 2, 3 ENSP000003487694) via UniProtKB, MINT, STRING, and/or I2D (see all 70)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046372, 3, ENSP000002693054MINT-8385595 MINT-8385459 MINT-8385531 MINT-8385886 MINT-8385510 MINT-63290 I2D: score=5 STRING: ENSP00000269305
    ARAP1Q96P482, 3MINT-63305 I2D: score=5 
    CBR3O758282, 3MINT-63289 I2D: score=5 
    EEF1GP266412, 3MINT-63293 I2D: score=5 
    ENSAO437682, 3MINT-63298 I2D: score=5 
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA19340006
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0007275multicellular organismal development TAS10422847
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA16118314
    GO:0048588developmental cell growth IDA19340006


    ARIH2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARIH2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARIH2
    Search CenterWatch for drugs/clinical trials and news about ARIH2 / ARI2 

    Transcripts
    for ARIH2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARIH2 gene: 
    NM_006321.2  

    Unigene Cluster for ARIH2:

    Ariadne homolog 2 (Drosophila)
    Hs.633601  [show with all ESTs]
    Unigene Representative Sequence: NM_006321
    18/31 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000452882 ENST00000430423(uc003cve.1) ENST00000478224 ENST00000356401(uc003cvb.3 uc003cvc.3 uc003cvf.3 uc010hkl.3)
    ENST00000498314 ENST00000474618 ENST00000492077 ENST00000463738 ENST00000490095
    ENST00000449376 ENST00000495761 ENST00000482427 ENST00000483333 ENST00000488963
    ENST00000420814 ENST00000486316 ENST00000449729 ENST00000433170

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ARIH2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARIH2
    8/39 QIAGEN miScript miRNA Assays for microRNAs that regulate ARIH2 (see all 39):
    hsa-miR-596 hsa-miR-3152-3p hsa-miR-642a hsa-miR-429 hsa-let-7a-2* hsa-miR-488 hsa-miR-570 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmid: ARIH2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARIH2 (see all 7)
    OriGene shRNA RFP: ARIH2
    OriGene siRNA: ARIH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARIH2
    Clone
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    GenScript: all cDNA clones in your preferred vector: ARIH2 (NM_006321)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARIH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARIH2 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARIH2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARIH2

    Additional cDNA sequence: 

    AB208857.1 AF099149.1 AF099150.1 AF099151.1 AF099152.1 AF099153.1 AF113677.1 AF183427.1 
    AJ130978.1 AK001800.1 AK091240.1 AK223550.1 AK307694.1 AK313434.1 AL110187.1 AL162034.1 
    BC000422.2 CR456785.1 

    24/48 DOTS entries (see all 48):

    DT.80100977  DT.100823541  DT.91836598  DT.95163707  DT.95163712  DT.120852490  DT.120852559  DT.120852584 
    DT.95082829  DT.100810548  DT.100823539  DT.120852458  DT.97782866  DT.100823538  DT.120852519  DT.95163715 
    DT.120852484  DT.75196705  DT.120852557  DT.120852627  DT.120852630  DT.91759032  DT.97861022  DT.100823542 

    24/417 AceView cDNA sequences (see all 417):

    CB241062 BQ232900 AU126005 CD673553 AU120172 CA428114 AA614863 BM272740 
    CB994243 BM971996 AA447893 BQ675241 AI356176 AW196440 BM833842 AA912700 
    AA631076 CA488189 BP370680 BM727066 AA988542 BG108159 Z40388 AV649774 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for ARIH2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                                                                                  
    SP2:                                                                                -                                 
    SP3:        -     -                                                                                                   
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ARIH2

    Expression
    for ARIH2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARIH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTGAACTGGC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ARIH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARIH2

    SOURCE GeneReport for Unigene cluster: Hs.633601

    UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
    Tissue specificity: Widely expressed with higher expression in granulocytes

        SABiosciences Expression via Pathway-Focused PCR Array including ARIH2: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARIH2

    Orthologs
    for ARIH2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARIH2 gene from 8/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARIH21 ariadne homolog 2 (Drosophila) 84.22(n)
    93.88(a)    		   416061  NM_001199221.1  NP_001186150.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARIH26
    		 --
    		 93(a)
    		 1 ↔ 1
    		 2(187720430-187747410)
    African clawed frog
    (Xenopus laevis)    		 Amphibia MGC686172 hypothetical protein MGC68617 80.01(n)    BC061943.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.257502 Danio rerio cDNA clone MGC64093 IMAGE6794947, complete more 77.16(n)    BC053248.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ari-21 , 3 ubiquitin-protein ligase3
    ariadne 21    		 55(a)3
    59.99(n)1
    57.17(a)1    		   58D23
    375421  NM_058026.31  NP_477374.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea T12E12.11 , 3 Protein T12E12.11 47(a)3
    52.06(n)1
    48.3(a)1    		   IV(5551336-5558586)3
    1773391  NM_068428.41  NP_500829.21 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ARI91 putative E3 ubiquitin-protein ligase ARI9 42.99(n)
    30.61(a)    		   817734  NM_128735.1  NP_180736.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 zinc finger protein-related, putative, expressed
    (see all 4)    		 22(a)
    21(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 3(23810739-23814756)
    3(23834237-23837762)


    ENSEMBL Gene Tree for ARIH2 (if available)
    TreeFam Gene Tree for ARIH2 (if available) 

    Paralogs
    for ARIH2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARIH2 gene
    ANKIB12  CUL72  CUL92  ARIH12  
    1 SIMAP similar gene for ARIH2 using alignment to 7 protein entries:     ARI2_HUMAN (see all proteins):
    ARIH1

    ARIH2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARIH2
    PGOHUM00000235034


    Genomic Variants
    for ARIH2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/841 NCBI SNPs in ARIH2 are shown (see all 841)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs600259361,2
    		C,--48954720(+) CTACAG/AGCGCC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1917350181,2
    		--48955339(+) GTTCAC/TGCCAT 2 -- us2k1 ut310--------
    rs1480463141,2
    		--48955386(+) GGCGCA/CCGCCA 2 -- ut31 us2k10--------
    rs1838683491,2
    		--48955452(+) GCCAGA/GATGGT 2 -- us2k1 ut310--------
    rs1810081391,2
    		C,--48956588(+) TACCCA/GCCGTC 2 -- ut51 int10--------
    rs1844698191,2
    		--48956670(+) GGCCAC/TCGCCT 2 -- ut51 int10--------
    rs98840221,2
    		C,F,A,H,--48956862(+) TCCCGC/GAGCCC 2 -- us2k1 int116Minor allele frequency- G:0.26NS EA NA WA CSA 942
    rs1384108311,2
    		--48957099(+) CTAAAC/TTTTAA 2 -- us2k1 int10--------
    rs98501341,2
    		C,F,A,H,--48957147(+) ACCACG/ATGTGG 2 -- int1 us2k123Minor allele frequency- A:0.28NS EA NA WA CSA 2352
    rs1904067231,2
    		--48957473(+) GTGGCA/GGCGAT 2 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for ARIH2 (48956254 - 49023815 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for ARIH2
         1 CNV: 98308

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for ARIH2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARIH2 for disorders           About GeneDecksing

    OMIM gene information: 605615    OMIM disorders: --

    2 diseases for ARIH2:    About MalaCards
    schizophrenia    malaria


    Export disorders for ARIH2 gene to outside databases

    Publications
    for ARIH2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARIH2 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with ARIH2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. TRIADs: a new class of proteins with a novel cysteine-rich signature. (PubMed id 10422847)1, 2, 3 van der Reijden B.A....Jansen J.H. (1999)
    2. The ubiquitin ligase Triad1 inhibits myelopoiesis thr ough UbcH7 and Ubc13 interacting domains. (PubMed id 19340006)1, 2, 9 Marteijn J.A....van der Reijden B.A. (2009)
    3. Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1. (PubMed id 17646546)1, 2 Marteijn J.A....Van der Reijden B.A. (2007)
    4. The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells. (PubMed id 16118314)1, 2 Marteijn J.A....van der Reijden B.A. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins. (PubMed id 10880484)1, 2 Aguilera M.... Ferrus A. (2000)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
    8. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    9. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
    10. TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation. (PubMed id 22819825)1 Bae S....An S. (2012)

    External Searches for ARIH2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ARIH2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 10425 HGNC: 690 AceView: ARIH2 Ensembl:ENSG00000177479 euGenes: HUgn10425
    ECgene: ARIH2 H-InvDB: ARIH2

    Other Databases showing ARIH2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARIH2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARIH2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARIH2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARIH2 gene:
    Search GeneIP for patents involving ARIH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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