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ARIH2 Gene

protein-coding   GIFtS: 61
GCID: GC03P048931

Ariadne RBR E3 Ubiquitin Protein Ligase 2

(Previous names: ariadne (Drosophila) homolog 2, ariadne homolog 2 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Ariadne RBR E3 Ubiquitin Protein Ligase 21 2     Ariadne (Drosophila) Homolog 21
ARI22 3 5     Ariadne Homolog 2 (Drosophila)1
TRIAD12 3 5     Ariadne Homolog 22
All-Trans Retinoic Acid Inducible RING Finger1 2     E3 Ubiquitin-Protein Ligase ARIH22
Protein Ariadne-2 Homolog2 3     EC 6.3.2.-3
ARI-22 3     Triad1 Protein3

External Ids:    HGNC: 6901   Entrez Gene: 104252   Ensembl: ENSG000001774797   OMIM: 6056155   UniProtKB: O953763   
ORGUL members:         

Export aliases for ARIH2 gene to outside databases

Previous GC identifers: GC03U990111 GC03P048231 GC03P048810 GC03P048915


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARIH2 Gene:
ARIH2 (ariadne RBR E3 ubiquitin protein ligase 2) is a protein-coding gene. Diseases associated with ARIH2 include schizophrenia, and malaria. GO annotations related to this gene include ubiquitin-protein ligase activity and nucleic acid binding. An important paralog of this gene is ANKIB1.

UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent
proteasomal degradation of modified proteins. May play a role in myelopoiesis

Gene Wiki entry for ARIH2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_022517.19  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARIH2 gene promoter:
         Nkx3-1   AhR   Elk-1   Pax-5   Nkx3-1 v1   Arnt   Nkx3-1 v2   POU2F1   POU2F1a   Nkx3-1 v3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARIH2 promoter sequence
   Search Chromatin IP Primers for ARIH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARIH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

ARIH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARIH2 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P048931:  view genomic region     (about GC identifiers)

Start:
48,956,254 bp from pter      End:
49,023,815 bp from pter
Size:
67,562 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ARIH2  
Size: 493 amino acids; 57819 Da
Subunit: Interacts (via RING-type 1) with UBE2L3. Interacts (via RING-type 2) with UBE2N. Interacts (via RING-type
2) with GFI1B. Interacts with GFI1; prevents its ubiquitination and proteasomal degradation
Sequence caution: Sequence=AAG09696.1; Type=Frameshift; Positions=Several;
Secondary accessions: Q9HBZ6 Q9UEM9

Explore the universe of human proteins at neXtProt for ARIH2: NX_O95376

Explore proteomics data for ARIH2 at MOPED

Post-translational modifications: 

  • Ubiquitinated. Ubiquitination promotes proteasomal degradation1
  • Ubiquitination2 at Lys364, Lys377, Lys460
  • Modification sites at PhosphoSitePlus

  • See ARIH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006312.1  
    ENSEMBL proteins: 
     ENSP00000395560   ENSP00000399788   ENSP00000348769   ENSP00000403222   ENSP00000397225  
     ENSP00000404838   ENSP00000406063   ENSP00000403845  
    Reactome Protein details: O95376

    ARIH2 Human Recombinant Protein Products:

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    OriGene Purified Protein for ARIH2
    OriGene Protein Over-expression Lysate for ARIH2
    OriGene MassSpec for ARIH2
    OriGene Custom Protein Services for ARIH2
    GenScript Custom Purified and Recombinant Proteins Services for ARIH2
    Novus Biologicals ARIH2 Proteins
    Novus Biologicals ARIH2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARIH2

    ARIH2 Antibody Products:

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    Abcam antibodies for ARIH2
    Cloud-Clone Corp. Antibodies for ARIH2
    ThermoFisher Antibody for ARIH2
    LSBio Antibodies in human, mouse, rat for ARIH2

    ARIH2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARIH2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARIH2
    Cloud-Clone Corp. CLIAs for ARIH2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    5 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR017907 Znf_RING_CS
     IPR002867 Znf_C6HC
     IPR001878 Znf_CCHC

    Graphical View of Domain Structure for InterPro Entry O95376

    ProtoNet protein and cluster: O95376

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB002867 Zn-finger


    UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
    Domain: RING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis
    Similarity: Belongs to the RBR family. Ariadne subfamily
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers


    ARIH2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARI2_HUMAN, O95376
    Function: E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent
    proteasomal degradation of modified proteins. May play a role in myelopoiesis
    Induction: Up-regulated by all-trans retinoic acid (ATRA). Up-regulated during differentiation of immature blood
    cells toward monocytes and granulocytes

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA16118314
    GO:0005515protein binding IPI16118314
    GO:0008270zinc ion binding IEA--
         
    ARIH2 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arih2):
     cardiovascular system  cellular  growth/size/body  immune system  integument 
     liver/biliary system  mortality/aging  respiratory system 

    ARIH2 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arih2tm1Mak for ARIH2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARIH2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARIH2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARIH2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARIH2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARIH2:
    hsa-mir-221-3p (MIRT003366), hsa-mir-1301-3p (MIRT035998), hsa-mir-19a-3p (MIRT005396), hsa-mir-93-5p (MIRT028030), hsa-mir-342-3p (MIRT043669)

    Block miRNA regulation of human, mouse, rat ARIH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARIH2 (see all 39):
    hsa-miR-596 hsa-miR-3152-3p hsa-miR-642a hsa-miR-429 hsa-let-7a-2* hsa-miR-488 hsa-miR-570 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidARIH2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARIH2
    Predesigned siRNA for gene silencing in human, mouse, rat ARIH2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARIH2

    Clone
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    OriGene clones in human, mouse for ARIH2 (see all 6)
    OriGene ORF clones in mouse, rat for ARIH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARIH2 (NM_006321)
    Sino Biological Human cDNA Clone for ARIH2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARIH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARIH2

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for ARIH2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARIH2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARIH2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARI2_HUMAN, O95376: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA16118314
    GO:0005737cytoplasm IDA19340006

    ARIH2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARIH2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for ARIH2
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
    Pathway: Protein modification; protein ubiquitination


    ARIH2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including ARIH2: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARIH2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARIH2 (O953761, 2, 3 ENSP000003487694) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TP53P046371, 2, 3, ENSP000002693054EBI-711158,EBI-366083 MINT-8385595 MINT-8385459 MINT-8385531 MINT-8385886 MINT-8385510 MINT-63290 I2D: score=5 STRING: ENSP00000269305
    ARAP1Q96P482, 3MINT-63305 I2D: score=5 
    CBR3O758282, 3MINT-63289 I2D: score=5 
    EEF1GP266412, 3MINT-63293 I2D: score=5 
    ENSAO437682, 3MINT-63298 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000209protein polyubiquitination IDA16118314
    GO:0006511ubiquitin-dependent protein catabolic process ----
    GO:0007275multicellular organismal development TAS10422847
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA16118314
    GO:0048588developmental cell growth IDA19340006

    ARIH2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARIH2 (ARI2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARIH2 gene: 
    NM_006321.2  

    Unigene Cluster for ARIH2:

    Ariadne homolog 2 (Drosophila)
    Hs.633601  [show with all ESTs]
    Unigene Representative Sequence: NM_006321
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 31):
    ENST00000452882 ENST00000430423(uc003cve.1) ENST00000478224 ENST00000356401(uc003cvb.3 uc003cvc.3 uc003cvf.3 uc010hkl.3)
    ENST00000498314 ENST00000474618 ENST00000492077 ENST00000463738 ENST00000490095
    ENST00000449376 ENST00000495761 ENST00000482427 ENST00000483333 ENST00000488963
    ENST00000420814 ENST00000486316 ENST00000449729 ENST00000433170
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARIH2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARIH2 (see all 39):
    hsa-miR-596 hsa-miR-3152-3p hsa-miR-642a hsa-miR-429 hsa-let-7a-2* hsa-miR-488 hsa-miR-570 hsa-miR-1184
    SwitchGear 3'UTR luciferase reporter plasmidARIH2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARIH2
    Predesigned siRNA for gene silencing in human, mouse, rat ARIH2
    Clone
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    OriGene clones in human, mouse for ARIH2 (see all 6)
    OriGene ORF clones in mouse, rat for ARIH2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARIH2 (NM_006321)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARIH2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARIH2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARIH2
    OriGene qSTAR qPCR primer pairs in human, mouse for ARIH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARIH2
      QuantiTect SYBR Green Assays in human, mouse, rat ARIH2
      QuantiFast Probe-based Assays in human, mouse, rat ARIH2

    Additional mRNA sequence: 

    AB208857.1 AF099149.1 AF099150.1 AF099151.1 AF099152.1 AF099153.1 AF113677.1 AF183427.1 
    AJ130978.1 AK001800.1 AK091240.1 AK223550.1 AK307694.1 AK313434.1 AL110187.1 AL162034.1 
    BC000422.2 CR456785.1 

    Selected DOTS entries (see all 48):

    DT.80100977  DT.100823541  DT.91836598  DT.95163707  DT.95163712  DT.120852490  DT.120852559  DT.120852584 
    DT.95082829  DT.100810548  DT.100823539  DT.120852458  DT.97782866  DT.100823538  DT.120852519  DT.95163715 
    DT.120852484  DT.75196705  DT.120852557  DT.120852627  DT.120852630  DT.91759032  DT.97861022  DT.100823542 

    Selected AceView cDNA sequences (see all 417):

    CB993029 AW168631 AF113677 AI494405 AA778413 BU734056 AI871865 AA912700 
    BE269881 AA976542 AA378337 AW771992 AI356176 BQ232900 AA631076 BM703364 
    BE327327 BG105948 BF726886 AI679456 AI066573 BP369113 BU180542 AA447893 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARIH2 (see all 6)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
    SP1:                                                                                                                  
    SP2:                                                                                -                                 
    SP3:        -     -                                                                                                   
    SP4:                                                                                                                  
    SP5:                                                                                                                  


    ECgene alternative splicing isoforms for ARIH2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARIH2 expression in normal human tissues (normalized intensities)      ARIH2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTGAACTGGC
    ARIH2 Expression
    About this image


    ARIH2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Proerythroblasts Hematopoietic Bone Marrow
    ARIH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARIH2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.633601

    UniProtKB/Swiss-Prot: ARI2_HUMAN, O95376
    Tissue specificity: Widely expressed with higher expression in granulocytes

        Pathway & Disease-focused RT2 Profiler PCR Array including ARIH2: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARIH2
    OriGene qSTAR qPCR primer pairs in human, mouse for ARIH2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARIH2
    QuantiTect SYBR Green Assays in human, mouse, rat ARIH2
    QuantiFast Probe-based Assays in human, mouse, rat ARIH2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARIH2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARIH2 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arih21 , 5 ariadne homolog 2 (Drosophila)1, 5 91.67(n)1
    98.17(a)1
      9 (59.54 cM)5
    238071  NM_011790.41  NP_035920.11 
     1086029425 
    chicken
    (Gallus gallus)
    Aves ARIH21 ariadne homolog 2 (Drosophila) 84.22(n)
    93.67(a)
      416061  NM_001199221.1  NP_001186150.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARIH26
    ariadne RBR E3 ubiquitin protein ligase 2
    93(a)
    1 ↔ 1
    2(187720334-187751602)
    African clawed frog
    (Xenopus laevis)
    Amphibia MGC686172 hypothetical protein MGC68617 80.01(n)    BC061943.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.257502 Danio rerio cDNA clone MGC64093 IMAGE6794947, complete more 77.16(n)    BC053248.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ari-21 , 3 ubiquitin-protein ligase3
    ariadne 21
    55(a)3
    60.58(n)1
    58.48(a)1
      58D23
    375421  NM_058026.31  NP_477374.11 
    worm
    (Caenorhabditis elegans)
    Secernentea T12E12.11 , 3 T12E12.11 47(a)3
    52.28(n)1
    49.34(a)1
      IV(5551336-5558586)3
    1773391  NM_068428.51  NP_500829.21 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes --
    Putative protein of unknown function; contains a R...
    23(a)
    1 → many
    XI(471694-473349) YKR017C
    rice
    (Oryza sativa)
    Liliopsida Os08g05403001 Os08g0540300 44.58(n)
    30.54(a)
      4346186  NM_001068917.1  NP_001062382.1 


    ENSEMBL Gene Tree for ARIH2 (if available)
    TreeFam Gene Tree for ARIH2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARIH2 gene
    ANKIB12  ARIH12  RNF19B2  RNF144A2  RNF144B2  RNF19A2  
    1 SIMAP similar gene for ARIH2 using alignment to 7 protein entries:     ARI2_HUMAN (see all proteins):
    ARIH1

    ARIH2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARIH2
    PGOHUM00000235034


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARIH2 (see all 972)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs600259361,2
    C,F--48954720(+) CTACAG/AGCGCC 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1494441461,2
    --48958976(+) ATTCTC/TCTGCC 1 -- int10--------
    rs1448363291,2
    --48959017(+) ATGCGC/TCACCA 1 -- int10--------
    rs1876858441,2
    --48959043(+) TGTGTG/TTTTTG 1 -- int10--------
    rs1162775691,2
    F--48959073(+) TGTTGC/TCCAGG 1 -- int11Minor allele frequency- T:0.01WA 118
    rs1485696871,2
    --48959145(+) GGGATG/TACTGG 1 -- int10--------
    rs1429105091,2
    --48959149(+) TTACTA/GGCATG 1 -- int10--------
    rs1465978521,2
    --48959601(+) ACAGTA/GAGCTG 1 -- int10--------
    rs117089061,2
    H--48959644(+) agaggC/Gaggcc 1 -- int10--------
    rs1919893961,2
    --48959888(+) CTCGAA/TCTCCT 1 -- int10--------

    HapMap Linkage Disequilibrium report for ARIH2 (48956254 - 49023815 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARIH2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2473053CNV Deletion19546169
    esv2725249CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARIH2
    DNA2.0 Custom Variant and Variant Library Synthesis for ARIH2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605615    OMIM disorders: --

    2 diseases for ARIH2:    About MalaCards
    schizophrenia    malaria


    ARIH2 for disorders           About GeneDecksing


    Export disorders for ARIH2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARIH2 gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with ARIH2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRIADs: a new class of proteins with a novel cysteine-rich signature. (PubMed id 10422847)1, 2, 3 van der Reijden B.A....Jansen J.H. (Protein Sci. 1999)
    2. The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains. (PubMed id 19340006)1, 2, 9 Marteijn J.A.... van der Reijden B.A. (Leukemia 2009)
    3. Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase. (PubMed id 24058416)1, 3 Spratt D.E....Shaw G.S. (PLoS ONE 2013)
    4. Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1. (PubMed id 17646546)1, 2 Marteijn J.A.... Van der Reijden B.A. (Blood 2007)
    5. The E3 ubiquitin-protein ligase Triad1 inhibits clonogenic growth of primary myeloid progenitor cells. (PubMed id 16118314)1, 2 Marteijn J.A....van der Reijden B.A. (Blood 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000)
    8. Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins. (PubMed id 10880484)1, 2 Aguilera M.... Ferrus A. (Genetics 2000)
    9. VCP phosphorylation-dependent interaction partners prevent apoptosis in Helicobacter pylori-infected gastric epithelial cells. (PubMed id 23383273)1 Yu C.C....Chow L.P. (PLoS ONE 2013)
    10. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes. (PubMed id 24076655)1 Kelsall I.R....Alpi A.F. (EMBO J. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10425 HGNC: 690 AceView: ARIH2 Ensembl:ENSG00000177479 euGenes: HUgn10425
    ECgene: ARIH2 H-InvDB: ARIH2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARIH2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARIH2 gene:
    Search GeneIP for patents involving ARIH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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