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Aliases for ARIH2 Gene

Aliases for ARIH2 Gene

  • Ariadne RBR E3 Ubiquitin Protein Ligase 2 2 3
  • TRIAD1 3 4 6
  • ARI2 3 4 6
  • All-Trans Retinoic Acid Inducible RING Finger 2 3
  • Protein Ariadne-2 Homolog 3 4
  • ARI-2 3 4
  • E3 Ubiquitin-Protein Ligase ARIH2 3
  • Ariadne (Drosophila) Homolog 2 2
  • Ariadne Homolog 2 (Drosophila) 2
  • Ariadne Homolog 2 3
  • Triad1 Protein 4
  • EC 6.3.2.- 4

External Ids for ARIH2 Gene

Summaries for ARIH2 Gene

GeneCards Summary for ARIH2 Gene

ARIH2 (Ariadne RBR E3 Ubiquitin Protein Ligase 2) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and nucleic acid binding. An important paralog of this gene is RNF19A.

UniProtKB/Swiss-Prot for ARIH2 Gene

  • E3 ubiquitin-protein ligase mediating Lys-48-and Lys-63-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.

Gene Wiki entry for ARIH2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARIH2 Gene

Genomics for ARIH2 Gene

Genomic Location for ARIH2 Gene

48,918,821 bp from pter
48,986,382 bp from pter
67,562 bases
Plus strand

Genomic View for ARIH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARIH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARIH2 Gene

Regulatory Elements for ARIH2 Gene

Proteins for ARIH2 Gene

  • Protein details for ARIH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase ARIH2
    Protein Accession:
    Secondary Accessions:
    • Q9HBZ6
    • Q9UEM9

    Protein attributes for ARIH2 Gene

    493 amino acids
    Molecular mass:
    57819 Da
    Quaternary structure:
    • Interacts (via RING-type 1) with UBE2L3. Interacts (via RING-type 2) with UBE2N. Interacts (via RING-type 2) with GFI1B. Interacts with GFI1; prevents its ubiquitination and proteasomal degradation.
    • Sequence=AAG09696.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305};

neXtProt entry for ARIH2 Gene

Proteomics data for ARIH2 Gene at MOPED

Post-translational modifications for ARIH2 Gene

  • Ubiquitinated. Ubiquitination promotes proteasomal degradation.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys364, Lys377, and Lys460

Other Protein References for ARIH2 Gene

No data available for DME Specific Peptides for ARIH2 Gene

Domains for ARIH2 Gene

Protein Domains for ARIH2 Gene


  • RING-type 1 and RING-type 2 are required for the inhibitory function in myelopoiesis:
    • O95376
  • Belongs to the RBR family. Ariadne subfamily.:
    • O95376
  • Contains 1 IBR-type zinc finger.:
    • O95376
  • Contains 2 RING-type zinc fingers.:
    • O95376
genes like me logo Genes that share domains with ARIH2: view

No data available for Gene Families for ARIH2 Gene

Function for ARIH2 Gene

Molecular function for ARIH2 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase mediating Lys-48-and Lys-63-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.
UniProtKB/Swiss-Prot Induction: Up-regulated by all-trans retinoic acid (ATRA). Up-regulated during differentiation of immature blood cells toward monocytes and granulocytes.

Enzyme Numbers (IUBMB) for ARIH2 Gene

Gene Ontology (GO) - Molecular Function for ARIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 16118314
GO:0005515 protein binding IPI 16118314
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with ARIH2: view
genes like me logo Genes that share phenotypes with ARIH2: view

Animal Models for ARIH2 Gene

MGI Knock Outs for ARIH2:

No data available for Transcription Factor Targeting and HOMER Transcription for ARIH2 Gene

Localization for ARIH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARIH2 Gene

Nucleus. Cytoplasm.

Subcellular locations from

Jensen Localization Image for ARIH2 Gene COMPARTMENTS Subcellular localization image for ARIH2 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for ARIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 16118314
GO:0005737 cytoplasm IDA 19340006
genes like me logo Genes that share ontologies with ARIH2: view

Pathways for ARIH2 Gene

genes like me logo Genes that share pathways with ARIH2: view

UniProtKB/Swiss-Prot O95376-ARI2_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ARIH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IDA 16118314
GO:0006511 ubiquitin-dependent protein catabolic process --
GO:0007275 multicellular organismal development TAS 10422847
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IDA 16118314
GO:0048588 developmental cell growth IDA 19340006
genes like me logo Genes that share ontologies with ARIH2: view

Transcripts for ARIH2 Gene

Unigene Clusters for ARIH2 Gene

Ariadne homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARIH2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16
SP2: -
SP3: - -

Relevant External Links for ARIH2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARIH2 Gene

mRNA expression in normal human tissues for ARIH2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARIH2 Gene

SOURCE GeneReport for Unigene cluster for ARIH2 Gene Hs.633601

mRNA Expression by UniProt/SwissProt for ARIH2 Gene

Tissue specificity: Widely expressed with higher expression in granulocytes.
genes like me logo Genes that share expressions with ARIH2: view

Orthologs for ARIH2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARIH2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARIH2 36
  • 99.59 (n)
  • 99.59 (a)
ARIH2 37
  • 100 (a)
(Bos Taurus)
Mammalia ARIH2 36
  • 93.01 (n)
  • 98.17 (a)
ARIH2 37
  • 98 (a)
(Canis familiaris)
Mammalia ARIH2 36
  • 94.37 (n)
  • 98.57 (a)
ARIH2 37
  • 97 (a)
(Mus musculus)
Mammalia Arih2 36
  • 91.67 (n)
  • 98.17 (a)
Arih2 16
Arih2 37
  • 98 (a)
(Monodelphis domestica)
Mammalia ARIH2 37
  • 94 (a)
(Ornithorhynchus anatinus)
Mammalia ARIH2 37
  • 84 (a)
(Rattus norvegicus)
Mammalia Arih2 36
  • 91.87 (n)
  • 98.37 (a)
(Gallus gallus)
Aves ARIH2 36
  • 84.22 (n)
  • 93.67 (a)
ARIH2 37
  • 94 (a)
(Anolis carolinensis)
Reptilia ARIH2 37
  • 93 (a)
African clawed frog
(Xenopus laevis)
Amphibia MGC68617 36
tropical clawed frog
(Silurana tropicalis)
Amphibia arih2 36
  • 81.33 (n)
  • 92.67 (a)
Str.746 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.8799 36
(Danio rerio)
Actinopterygii arih2 36
  • 76.65 (n)
  • 82.23 (a)
arih2 37
  • 81 (a)
Dr.25750 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005977 36
  • 61.04 (n)
  • 59.74 (a)
fruit fly
(Drosophila melanogaster)
Insecta ari-2 36
  • 60.58 (n)
  • 58.48 (a)
ari-2 37
  • 53 (a)
ari-2 38
  • 55 (a)
(Caenorhabditis elegans)
Secernentea T12E12.1 36
  • 52.28 (n)
  • 49.34 (a)
T12E12.1 37
  • 46 (a)
T12E12.1 38
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 23 (a)
(Oryza sativa)
Liliopsida Os08g0540300 36
  • 44.58 (n)
  • 30.54 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1806 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 55 (a)
Species with no ortholog for ARIH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARIH2 Gene

Gene Tree for ARIH2 (if available)
Gene Tree for ARIH2 (if available)

Paralogs for ARIH2 Gene

Paralogs for ARIH2 Gene

Selected SIMAP similar genes for ARIH2 Gene using alignment to 7 proteins: Pseudogenes for ARIH2 Gene

genes like me logo Genes that share paralogs with ARIH2: view

Variants for ARIH2 Gene

Sequence variations from dbSNP and Humsavar for ARIH2 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs11507 - 48,927,628(+) aggaa(A/G)aggaa missense, reference, utr-variant-5-prime, intron-variant
rs1134591 -- 48,935,459(+) CCTAT(A/G)TATTA intron-variant
rs3202411 -- 48,938,759(+) TCATT(A/C)CAAAA intron-variant
rs4974078 -- 48,971,953(+) CCCGA(C/T)GAATA intron-variant
rs4974082 -- 48,961,890(+) TACTA(A/G)CACAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARIH2 Gene

Variant ID Type Subtype PubMed ID
esv2473053 CNV Deletion 19546169
esv2725249 CNV Deletion 23290073

Relevant External Links for ARIH2 Gene

HapMap Linkage Disequilibrium report

Disorders for ARIH2 Gene

No disorders were found for ARIH2 Gene.

No data available for UniProtKB/Swiss-Prot for ARIH2 Gene

Publications for ARIH2 Gene

  1. TRIADs: a new class of proteins with a novel cysteine-rich signature. (PMID: 10422847) van der Reijden B.A. … Jansen J.H. (Protein Sci. 1999) 2 3 4
  2. The ubiquitin ligase Triad1 inhibits myelopoiesis through UbcH7 and Ubc13 interacting domains. (PMID: 19340006) Marteijn J.A. … van der Reijden B.A. (Leukemia 2009) 3 4 23
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins. (PMID: 10880484) Aguilera M. … Ferrus A. (Genetics 2000) 3 4
  5. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4

Products for ARIH2 Gene

Sources for ARIH2 Gene

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