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Aliases for ARIH1 Gene

Aliases for ARIH1 Gene

  • Ariadne RBR E3 Ubiquitin Protein Ligase 1 2 3
  • UBCH7BP 3 4 6
  • ARI 3 4 6
  • Ubiquitin-Conjugating Enzyme E2-Binding Protein 1 3 4
  • Protein Ariadne-1 Homolog 3 4
  • UbcM4-Interacting Protein 3 4
  • UbcH7-Binding Protein 3 4
  • Monocyte Protein 6 3 4
  • H7-AP2 3 4
  • ARI-1 3 4
  • HHARI 3 4
  • MOP-6 3 4
  • Ariadne (Drosophila) Homolog, Ubiquitin-Conjugating Enzyme E2-Binding Protein, 1 2
  • Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (Drosophila) 2
  • Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 3
  • E3 Ubiquitin-Protein Ligase ARIH1 3
  • Ariadne, Drosophila, Homolog Of 3
  • Drosophila 2
  • Homolog Of 2
  • EC 6.3.2.- 4
  • Ariadne 2
  • HARI 3
  • MOP6 4

External Ids for ARIH1 Gene

Previous GeneCards Identifiers for ARIH1 Gene

  • GC15P068568
  • GC15P065871
  • GC15P070342
  • GC15P070482
  • GC15P070553
  • GC15P072766
  • GC15P049597

Summaries for ARIH1 Gene

GeneCards Summary for ARIH1 Gene

ARIH1 (Ariadne RBR E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Among its related pathways are Interferon Signaling and Interferon Signaling. GO annotations related to this gene include ubiquitin-protein transferase activity and ubiquitin-like protein transferase activity. An important paralog of this gene is RNF19A.

UniProtKB/Swiss-Prot for ARIH1 Gene

  • E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2.

Gene Wiki entry for ARIH1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARIH1 Gene

Genomics for ARIH1 Gene

Regulatory Elements for ARIH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARIH1 Gene

Start:
72,474,282 bp from pter
End:
72,602,985 bp from pter
Size:
128,704 bases
Orientation:
Plus strand

Genomic View for ARIH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARIH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARIH1 Gene

Proteins for ARIH1 Gene

  • Protein details for ARIH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4X5-ARI1_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase ARIH1
    Protein Accession:
    Q9Y4X5
    Secondary Accessions:
    • B2R6U3
    • O76026
    • Q9H3T6
    • Q9UEN0
    • Q9UP39

    Protein attributes for ARIH1 Gene

    Size:
    557 amino acids
    Molecular mass:
    64118 Da
    Quaternary structure:
    • Interacts with UBE2L3.
    Miscellaneous:
    • Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain (PubMed:21532592).

    Three dimensional structures from OCA and Proteopedia for ARIH1 Gene

neXtProt entry for ARIH1 Gene

Proteomics data for ARIH1 Gene at MOPED

Post-translational modifications for ARIH1 Gene

  • Ubiquitination at Lys144, Lys156, and Lys286
  • Modification sites at PhosphoSitePlus

Other Protein References for ARIH1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARIH1 Gene

Domains for ARIH1 Gene

Protein Domains for ARIH1 Gene

Suggested Antigen Peptide Sequences for ARIH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4X5

UniProtKB/Swiss-Prot:

ARI1_HUMAN :
  • Q9Y4X5
Domain:
  • The RING-type 2 zinc finger is atypical: it only binds 1 zinc ion instead of 2 and uses a different hydrophobic network compared to classical RING-types.
Family:
  • Belongs to the RBR family. Ariadne subfamily.
Similarity:
  • Contains 1 IBR-type zinc finger.
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with ARIH1: view

No data available for Gene Families for ARIH1 Gene

Function for ARIH1 Gene

Molecular function for ARIH1 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2.

Enzyme Numbers (IUBMB) for ARIH1 Gene

Gene Ontology (GO) - Molecular Function for ARIH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 14623119
GO:0005515 protein binding IPI 10521492
GO:0008270 zinc ion binding IDA 15236971
GO:0016874 ligase activity IEA --
GO:0019787 ubiquitin-like protein transferase activity TAS 10521492
genes like me logo Genes that share ontologies with ARIH1: view

Phenotypes for ARIH1 Gene

genes like me logo Genes that share phenotypes with ARIH1: view

Animal Model Products

CRISPR Products

miRNA for ARIH1 Gene

miRTarBase miRNAs that target ARIH1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARIH1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for ARIH1 Gene

Localization for ARIH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARIH1 Gene

Cytoplasm. Note=Mainly cytoplasmic.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARIH1 Gene COMPARTMENTS Subcellular localization image for ARIH1 gene
Compartment Confidence
cytosol 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARIH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000151 ubiquitin ligase complex TAS 10521492
GO:0005737 cytoplasm IDA 11278816
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARIH1: view

Pathways for ARIH1 Gene

genes like me logo Genes that share pathways with ARIH1: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9Y4X5-ARI1_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for ARIH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process TAS 10521492
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with ARIH1: view

Transcripts for ARIH1 Gene

Unigene Clusters for ARIH1 Gene

Ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARIH1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARIH1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b
SP1: - - - -
SP2: -
SP3: -
SP4:

Relevant External Links for ARIH1 Gene

GeneLoc Exon Structure for
ARIH1
ECgene alternative splicing isoforms for
ARIH1

Expression for ARIH1 Gene

mRNA expression in normal human tissues for ARIH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARIH1 Gene

SOURCE GeneReport for Unigene cluster for ARIH1 Gene Hs.268787

mRNA Expression by UniProt/SwissProt for ARIH1 Gene

Q9Y4X5-ARI1_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with ARIH1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARIH1 Gene

Orthologs for ARIH1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for ARIH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARIH1 35
  • 99.94 (n)
  • 100 (a)
ARIH1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARIH1 35
  • 96.16 (n)
  • 97.84 (a)
ARIH1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARIH1 35
  • 96.16 (n)
  • 97.84 (a)
ARIH1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arih1 35
  • 95.56 (n)
  • 99.28 (a)
Arih1 16
Arih1 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARIH1 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARIH1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arih1 35
  • 95.86 (n)
  • 99.28 (a)
chicken
(Gallus gallus)
Aves ARIH1 35
  • 90.83 (n)
  • 100 (a)
ARIH1 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARIH1 36
  • 96 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.16641 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arih1 35
  • 81.03 (n)
  • 94.71 (a)
Str.5440 35
zebrafish
(Danio rerio)
Actinopterygii arih1 35
  • 82.73 (n)
  • 92.6 (a)
arih1 36
  • 95 (a)
OneToMany
arih1l 36
  • 92 (a)
OneToMany
wufa18d01 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010891 35
  • 66.09 (n)
  • 71.8 (a)
fruit fly
(Drosophila melanogaster)
Insecta ari-1 35
  • 65.72 (n)
  • 70.81 (a)
ari-1 36
  • 68 (a)
OneToMany
CG12362 36
  • 54 (a)
OneToMany
ari-1 37
  • 70 (a)
CG12362 37
  • 57 (a)
worm
(Caenorhabditis elegans)
Secernentea ari-1 36
  • 53 (a)
OneToMany
C27A12.6 36
  • 48 (a)
OneToMany
C27A12.7 36
  • 48 (a)
OneToMany
tag-349 36
  • 46 (a)
OneToMany
C27A12.6 37
  • 50 (a)
C27A12.8 37
  • 55 (a)
Y73F8A.34 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 28 (a)
OneToMany
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons ARI2 35
  • 46.24 (n)
  • 36.23 (a)
rice
(Oryza sativa)
Liliopsida Os03g0233500 35
  • 47.83 (n)
  • 36.61 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06882 35
  • 52.6 (n)
  • 45.09 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC328.02 35
  • 51.69 (n)
  • 46.95 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1327 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11309 36
  • 65 (a)
OneToOne
Species with no ortholog for ARIH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARIH1 Gene

ENSEMBL:
Gene Tree for ARIH1 (if available)
TreeFam:
Gene Tree for ARIH1 (if available)

Paralogs for ARIH1 Gene

Paralogs for ARIH1 Gene

genes like me logo Genes that share paralogs with ARIH1: view

Variants for ARIH1 Gene

Sequence variations from dbSNP and Humsavar for ARIH1 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs14636 -- 72,583,333(+) ACCAT(A/C)TAGAG utr-variant-3-prime
rs997952 -- 72,513,098(-) ttttt(A/T)aaaaa intron-variant
rs1136789 -- 72,566,597(+) CTGTT(A/C)AATGT reference, missense
rs1136802 -- 72,585,158(+) CTGTT(C/T)TTTTC utr-variant-3-prime
rs1141831 -- 72,555,851(+) GGTCA(C/G)ACTAT splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for ARIH1 Gene

Variant ID Type Subtype PubMed ID
nsv469704 CNV Loss 16826518
nsv827384 CNV Gain 20364138
dgv755e1 CNV Complex 17122850
nsv428307 CNV Gain 18775914
nsv483057 CNV Loss 15286789
nsv521972 CNV Gain 19592680

Relevant External Links for ARIH1 Gene

HapMap Linkage Disequilibrium report
ARIH1
Human Gene Mutation Database (HGMD)
ARIH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARIH1 Gene

Disorders for ARIH1 Gene

Relevant External Links for ARIH1

Genetic Association Database (GAD)
ARIH1
genes like me logo Genes that share disorders with ARIH1: view

No data available for UniProtKB/Swiss-Prot for ARIH1 Gene

Publications for ARIH1 Gene

  1. Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins. (PMID: 10880484) Aguilera M. … Ferrus A. (Genetics 2000) 3 4 23
  2. Characterisation of the human and mouse orthologues of the Drosophila ariadne gene. (PMID: 11124525) Tan N.G. … Robinson P.A. (Cytogenet. Cell Genet. 2000) 3 4 23
  3. Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. (PMID: 11278816) Ardley H.C. … Robinson P.A. (J. Biol. Chem. 2001) 3 4 23
  4. The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. (PMID: 10521492) Moynihan T.P. … Robinson P.A. (J. Biol. Chem. 1999) 2 3 4
  5. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PMID: 11124703) Stanchi F. … Valle G. (Yeast 2001) 3 4

Products for ARIH1 Gene

  • Addgene plasmids for ARIH1

Sources for ARIH1 Gene

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