Aliases for ARIH1 Gene
- MOP-6 3 4
- ARI 3 4
- Ariadne (Drosophila) Homolog, Ubiquitin-Conjugating Enzyme E2-Binding Protein, 1 2
- Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 (Drosophila) 2
- Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1 3
- E3 Ubiquitin-Protein Ligase ARIH1 3
- EC 6.3.2.- 4
- HARI 3
- MOP6 4
External Ids for ARIH1 Gene
Previous GeneCards Identifiers for ARIH1 Gene
GeneCards Summary for ARIH1 Gene
ARIH1 (Ariadne RBR E3 Ubiquitin Protein Ligase 1) is a Protein Coding gene. Diseases associated with ARIH1 include Sleep Disorder and Aortic Valve Insufficiency. Among its related pathways are Regulation of Glucokinase by Glucokinase Regulatory Protein and Interleukin-3, 5 and GM-CSF signaling. GO annotations related to this gene include ligase activity and ubiquitin protein ligase binding. An important paralog of this gene is ARIH2.
UniProtKB/Swiss-Prot for ARIH1 Gene
E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of EIF4E2, leading to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2.