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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARIH1 Gene

protein-coding   GIFtS: 57
GCID: GC15P072766

ariadne homolog, ubiquitin-conjugating enzyme E2 binding...

(Previous names: ariadne (Drosophila) homolog, ubiquitin-conjugating enzyme...)
 Explore 4 diseases affiliated with
ARIH1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARIH1    

Aliases
for ARIH1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1
(Drosophila)1 2
     Ubiquitin-Conjugating Enzyme E2-Binding Protein 12 3
ARI1 2 3 5     ARI-12 3
UBCH7BP1 2 3 5     H7-AP22 3
HHARI1 2 3     MOP-62 3
HARI1 2     Ariadne (Drosophila) Homolog, Ubiquitin-Conjugating Enzyme E2-Binding Protein,
11
Monocyte Protein 62 3     Ariadne, Drosophila, Homolog Of2
Protein Ariadne-1 Homolog2 3     E3 Ubiquitin-Protein Ligase ARIH12
UbcH7-Binding Protein2 3     EC 6.3.2.-3
UbcM4-Interacting Protein2 3     MOP63

External Ids:    HGNC: 6891   Entrez Gene: 258202   Ensembl: ENSG000001662337   OMIM: 6056245   UniProtKB: Q9Y4X53   

Export aliases for ARIH1 gene to outside databases

Previous GC identifers: GC15P068568 GC15P065871 GC15P070342 GC15P070482 GC15P070553 GC15P049597


Summaries
for ARIH1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: ARI1_HUMAN, Q9Y4X5
Function: E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with
ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of
EIF4E2, leading to its subsequent degradation

Gene Wiki entry for ARIH1


Genomic Views
for ARIH1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARIH1 gene promoter:
         Bach1   ER-alpha   C/EBPbeta   RFX1   Sp1   p300   CREB   E2F-1   deltaCREB   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARIH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARIH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARIH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24

ARIH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARIH1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P072766:  view genomic region     (about GC identifiers)

Start:
 72,766,667 bp from pter      End:
 72,879,692 bp from pter
Size:
 113,026 bases      Orientation:
 plus strand

Proteins
for ARIH1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARI1_HUMAN, Q9Y4X5 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ARIH1  
Size: 557 amino acids; 64118 Da
Subunit: Interacts with UBE2L3
Subcellular location: Cytoplasm. Note=Mainly cytoplasmic
Miscellaneous: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme UBE2L3
and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate
trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING domain
(PubMed:21532592)
1 PDB 3D structure from and Proteopedia for ARIH1:
1WD2 (3D)    
Secondary accessions: B2R6U3 O76026 Q9H3T6 Q9UEN0 Q9UP39

Explore the universe of human proteins at neXtProt for ARIH1: NX_Q9Y4X5

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9Y4X5

    • ARIH1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_005735.2  
    ENSEMBL proteins: 
     ENSP00000369217   ENSP00000456746   ENSP00000454774   ENSP00000457767  
    Reactome Protein details: Q9Y4X5
    Human Recombinant Protein Products: 
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    Uscn Proteins for ARIH1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS10521492
    GO:0005737cytoplasm IDA11278816
    GO:0005829cytosol TAS--


    ARIH1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ARIH1

    Protein Domains /
    Families
    for ARIH1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARIH1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR002867 Znf_C6HC
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9Y4X5

    ProtoNet protein and cluster: Q9Y4X5

    2 Blocks protein families:
    IPB001841 Zn-finger
    IPB002867 Zn-finger


    UniProtKB/Swiss-Prot: ARI1_HUMAN, Q9Y4X5
    Domain: The RING-type 2 zinc finger is atypical: it only binds 1 zinc ion instead of 2 and uses a different hydrophobic
    network compared to classical RING-types
    Similarity: Belongs to the RBR family. Ariadne subfamily
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers


    Function
    for ARIH1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARI1_HUMAN, Q9Y4X5
    Function: E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with
    ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of
    EIF4E2, leading to its subsequent degradation

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate ARIH1 (see all 46):
    hsa-miR-642a hsa-miR-429 hsa-miR-548k hsa-let-7a-2* hsa-miR-219-5p hsa-miR-186 hsa-miR-3909 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ARIH1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARIH1 (see all 7)
    OriGene shRNA RFP: ARIH1
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARIH1

    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for ARIH1

    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding IPI14623119
    GO:0008270zinc ion binding IDA15236971
    GO:0019787small conjugating protein ligase activity TAS10521492
    GO:0031625ubiquitin protein ligase binding IPI--


    ARIH1 for ontologies           About GeneDecksing


    3 GenomeRNAi human phenotypes for ARIH1:
     Increased cell death HMECs cel  Increased cilium length  Increased cilium length after  


    Pathways & Interactions
    for ARIH1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cytokine Signaling in Immune system
    		Cytokine Signaling in Immune system1.00
    		Interferon Signaling0.61
    2Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus
    		Antiviral mechanism by IFN-stimulated genes0.49
    		ISG15 antiviral mechanism0.49
    3Immune System
    		Immune System1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for ARIH1
        Antiviral mechanism by IFN-stimulated genes
    Cytokine Signaling in Immune system
    Interferon Signaling
    ISG15 antiviral mechanism
    Immune System


    UniProtKB/Swiss-Prot: ARI1_HUMAN, Q9Y4X5
    Pathway: Protein modification; protein ubiquitination


    ARIH1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARIH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/34 Interacting proteins for ARIH1 (Q9Y4X53 ENSP000003692174) via UniProtKB, MINT, STRING, and/or I2D (see all 34)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4E2O605733, ENSP000002584164I2D: score=3 STRING: ENSP00000258416
    UBE2L6O149333, ENSP000002871564I2D: score=2 STRING: ENSP00000287156
    SIM2Q141903, ENSP000002903994I2D: score=1 STRING: ENSP00000290399
    VAV2P527353, ENSP000003609164I2D: score=1 STRING: ENSP00000360916
    UBE2L3P680363, ENSP000003442594I2D: score=4 STRING: ENSP00000344259
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process TAS10521492
    GO:0016567protein ubiquitination IDA--
    GO:0019221cytokine-mediated signaling pathway TAS--


    ARIH1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARIH1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARIH1
    Search CenterWatch for drugs/clinical trials and news about ARIH1 / ARI1 

    Transcripts
    for ARIH1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARIH1 gene: 
    NM_005744.3  

    Unigene Cluster for ARIH1:

    Ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
    Hs.268787  [show with all ESTs]
    Unigene Representative Sequence: NM_005744
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379887(uc002aut.4) ENST00000570085 ENST00000564062 ENST00000567762
    ENST00000561987 ENST00000565950 ENST00000561770 ENST00000566063 ENST00000562891
    ENST00000563310

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARIH1
    8/46 QIAGEN miScript miRNA Assays for microRNAs that regulate ARIH1 (see all 46):
    hsa-miR-642a hsa-miR-429 hsa-miR-548k hsa-let-7a-2* hsa-miR-219-5p hsa-miR-186 hsa-miR-3909 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmid: ARIH1 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARIH1 (see all 7)
    OriGene shRNA RFP: ARIH1
    Browse OriGene siRNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ARIH1 (NM_005744)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARIH1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARIH1

    Additional cDNA sequence: 

    AB014774.1 AB209432.1 AF072832.1 AJ009771.1 AJ130976.1 AJ243190.1 AK000336.1 AK312715.1 
    AL117650.1 BC051877.1 

    14 DOTS entries:

    DT.444399  DT.100814845  DT.100684898  DT.40121401  DT.92443023  DT.95276343  DT.100821516  DT.95308543 
    DT.91699068  DT.95276339  DT.95276340  DT.95276345  DT.92443030  DT.97769697 

    24/374 AceView cDNA sequences (see all 374):

    BQ049265 BE326348 AA988941 AV682399 BM353676 AB014774 AI277671 AL712891 
    F10672 AA935881 BQ014906 CF529763 Z41271 AI472117 BX493421 AA598462 
    BC051877 BM806799 AW192641 BQ773745 AW513350 BG571018 BU183206 AA630409 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARIH1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b
    SP1:                                            -                 -                       -                 -                           
    SP2:                                                                                      -                                             
    SP3:                                                                                                        -                           
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for ARIH1

    Expression
    for ARIH1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARIH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATTAGGAACT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See ARIH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARIH1

    SOURCE GeneReport for Unigene cluster: Hs.268787

    UniProtKB/Swiss-Prot: ARI1_HUMAN, Q9Y4X5
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Arrays including ARIH1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARIH1

    Orthologs
    for ARIH1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARIH1 gene from 8/33 species (see all 33)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARIH11 ariadne homolog, ubiquitin-conjugating enzyme E2 binding more 90.83(n)
    100(a)    		   415319  NM_001030387.1  NP_001025558.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARIH16
    		 --
    		 99(a)
    		 1 ↔ 1
    		 GL343872.1(82141-93751)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.166412 Xenopus laevis transcribed sequence with strong similarity more 83.08(n)    BU899532.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufa18d012 wufa18d01 81.25(n)   327005  BC057523.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta ari-11 , 3 ubiquitin-protein ligase3
    ariadne1    		 70(a)
    (best of 2)3
    65.72(n)1
    70.81(a)1    		   1 16F73
    327961  NM_078675.31  NP_523399.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea C27A12.83
    ari-11    		 Protein ARI-11 55(a)
    (best of 3)3
    57.94(n)1
    56.66(a)1    		   I(6066989-6069088)3
    1722841  NM_059348.41  NP_491749.21 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ARARI36
    ARI26
    (see all 4)    		 ariadne-1
    (see all 4)    		 25(a)
    24(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 3(10269206-10271065)
    2(6986834-6990051)
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 4)    		 ariadne-1, putative, expressed
    (see all 4)    		 24(a)
    24(a)
    (see all 4)    		 many ↔ many
    many ↔ many
    (see all 4)    		 3(23810739-23814756)
    3(7073682-7078258)


    ENSEMBL Gene Tree for ARIH1 (if available)
    TreeFam Gene Tree for ARIH1 (if available) 

    Paralogs
    for ARIH1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARIH1 gene
    ANKIB12  CUL72  CUL92  ARIH22  
    18/55 SIMAP similar genes for ARIH1 using alignment to 4 protein entries:     ARI1_HUMAN (see all proteins) (see all similar genes):
    ARL6IP5    KIAA1651    NCKAP1L    ADCK1    pp12301    EEF1E1
    IDNK    TBCB    FLJ00047    KIAA0101    CDK10    COQ5
    DYNC2LI1    EIF3K    NDC80    NLRC5    DOCK8    ZNF554

    ARIH1 for paralogs           About GeneDecksing



    Genomic Variants
    for ARIH1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1664 NCBI SNPs in ARIH1 are shown (see all 1664)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs798101741,2
    		F,--72764680(+) GAAAAG/CAAAGG 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs2013201851,2
    		--72764686(+) AAGGT-/GAGGC 
                GAGGC     		1 -- us2k10--------
    rs1813045411,2
    		--72764689(+) GGTGAC/GGCAAA 1 -- us2k10--------
    rs1855642191,2
    		--72764711(+) TACTGA/CCGAGT 1 -- us2k10--------
    rs285755041,2
    		C,--72764817(+) TAGAAT/CTGCTA 1 -- us2k1 tfbs32Minor allele frequency- C:0.05WA 120
    rs1463717661,2
    		--72764949(+) CTGGCA/CAATAT 1 -- us2k10--------
    rs1384396681,2
    		--72765005(+) GGTGGC/TATGCG 1 -- us2k10--------
    rs2001389181,2
    		C,--72765047(+) AGGAG-/AAATCG 1 -- us2k10--------
    rs1429428801,2
    		--72765191(+) TGAGGC/TTAAAT 1 -- us2k10--------
    rs1910979701,2
    		--72765250(+) TAAAAC/TTTACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARIH1 (72766667 - 72879692 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ARIH1
         3 CNVs: 0189 3967 2195
    Human Gene Mutation Database (HGMD): ARIH1

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    Disorders / Diseases
    for ARIH1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARIH1 for disorders           About GeneDecksing

    OMIM gene information: 605624    OMIM disorders: --

    4 diseases for ARIH1:    About MalaCards
    bovine spongiform encephalopathy    malaria    pancreatic cancer    pancreatitis


    Export disorders for ARIH1 gene to outside databases

    Publications
    for ARIH1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARIH1 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with ARIH1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. (PubMed id 10521492)1, 2, 3 Moynihan T.P.... Robinson P.A. (1999)
    2. Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. (PubMed id 11278816)1, 2, 9 Ardley H.C.... Robinson P.A. (2001)
    3. Characterisation of the human and mouse orthologues of the Drosophila ariadne gene. (PubMed id 11124525)1, 2, 9 Tan N.G....Robinson P.A. (2000)
    4. Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins. (PubMed id 10880484)1, 2, 9 Aguilera M.... Ferrus A. (2000)
    5. UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. (PubMed id 21532592)1, 2 Wenzel D.M.... Klevit R.E. (2011)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING. (PubMed id 15236971)1, 2 Capili A.D....Borden K.L. (2004)
    8. Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP. (PubMed id 14623119)1, 2 Tan N.G....Robinson P.A. (2003)
    9. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2 Stanchi F.... Valle G. (2001)
    10. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)

    External Searches for ARIH1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing ARIH1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25820 HGNC: 689 AceView: ARIH1 Ensembl:ENSG00000166233 euGenes: HUgn25820
    ECgene: ARIH1 H-InvDB: ARIH1

    Other Databases showing ARIH1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARIH1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARIH1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARIH1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARIH1 gene:
    Search GeneIP for patents involving ARIH1

    GeneCards and IP:
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