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ARIH1 Gene

protein-coding   GIFtS: 61
GCID: GC15P072766

Ariadne RBR E3 Ubiquitin Protein Ligase 1

(Previous names: ariadne (Drosophila) homolog, ubiquitin-conjugating enzyme...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Ariadne RBR E3 Ubiquitin Protein Ligase 11 2     Drosophila1
ARI2 3 5     ariadne1
UBCH7BP2 3 5     Ariadne (Drosophila) Homolog, Ubiquitin-Conjugating Enzyme E2-Binding
Protein, 11
Monocyte Protein 62 3     Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 1
(Drosophila)1
Protein Ariadne-1 Homolog2 3     Homolog Of1
UbcH7-Binding Protein2 3     HARI2
UbcM4-Interacting Protein2 3     Ariadne Homolog, Ubiquitin-Conjugating Enzyme E2 Binding Protein, 12
Ubiquitin-Conjugating Enzyme E2-Binding Protein 12 3     Ariadne, Drosophila, Homolog Of2
ARI-12 3     E3 Ubiquitin-Protein Ligase ARIH12
H7-AP22 3     EC 6.3.2.-3
HHARI2 3     MOP63
MOP-62 3     

External Ids:    HGNC: 6891   Entrez Gene: 258202   Ensembl: ENSG000001662337   OMIM: 6056245   UniProtKB: Q9Y4X53   

Export aliases for ARIH1 gene to outside databases

Previous GC identifers: GC15P068568 GC15P065871 GC15P070342 GC15P070482 GC15P070553 GC15P049597


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for ARIH1 Gene:
ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and small conjugating protein ligase activity. An important paralog of this gene is ANKIB1.

UniProtKB/Swiss-Prot: ARI1_HUMAN, Q9Y4X5
Function: E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with
ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of
EIF4E2, leading to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2

Gene Wiki entry for ARIH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARIH1 gene promoter:
         Bach1   ER-alpha   C/EBPbeta   RFX1   Sp1   p300   CREB   E2F-1   deltaCREB   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARIH1 promoter sequence
   Search Chromatin IP Primers for ARIH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARIH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24   Ensembl cytogenetic band:  15q24.1   HGNC cytogenetic band: 15q24

ARIH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARIH1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P072766:  view genomic region     (about GC identifiers)

Start:
72,766,667 bp from pter      End:
72,879,692 bp from pter
Size:
113,026 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARI1_HUMAN, Q9Y4X5 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase ARIH1  
Size: 557 amino acids; 64118 Da
Subunit: Interacts with UBE2L3
Miscellaneous: Members of the RBR family are atypical E3 ligases. They interact with the E2 conjugating enzyme
UBE2L3 and function like HECT-type E3 enzymes: they bind E2s via the first RING domain, but require an obligate
trans-thiolation step during the ubiquitin transfer, requiring a conserved cysteine residue in the second RING
domain (PubMed:21532592)
4 PDB 3D structures from and Proteopedia for ARIH1:
1WD2 (3D)        2M9Y (3D)        4KBL (3D)        4KC9 (3D)    
Secondary accessions: B2R6U3 O76026 Q9H3T6 Q9UEN0 Q9UP39

Explore the universe of human proteins at neXtProt for ARIH1: NX_Q9Y4X5

Explore proteomics data for ARIH1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys144, Lys156, Lys286
  • Modification sites at PhosphoSitePlus

  • See ARIH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005735.2  
    ENSEMBL proteins: 
     ENSP00000369217   ENSP00000456746   ENSP00000454774   ENSP00000457767  
    Reactome Protein details: Q9Y4X5

    ARIH1 Human Recombinant Protein Products:

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    antibodies-online peptides for ARIH1

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    antibodies-online antibodies for ARIH1 (13 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD
     IPR002867 Znf_C6HC

    Graphical View of Domain Structure for InterPro Entry Q9Y4X5

    ProtoNet protein and cluster: Q9Y4X5

    2 Blocks protein domains:
    IPB001841 Zn-finger
    IPB002867 Zn-finger


    UniProtKB/Swiss-Prot: ARI1_HUMAN, Q9Y4X5
    Domain: The RING-type 2 zinc finger is atypical: it only binds 1 zinc ion instead of 2 and uses a different
    hydrophobic network compared to classical RING-types
    Similarity: Belongs to the RBR family. Ariadne subfamily
    Similarity: Contains 1 IBR-type zinc finger
    Similarity: Contains 2 RING-type zinc fingers


    Find genes that share domains with ARIH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARI1_HUMAN, Q9Y4X5
    Function: E3 ubiquitin-protein ligase, which catalyzes polyubiquitination of target proteins together with
    ubiquitin-conjugating enzyme E2 UBE2L3. May play a role in protein translation by mediating polyubiquitination of
    EIF4E2, leading to its subsequent degradation. Acts as the ligase involved in ISGylation of EIF4E2

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA14623119
    GO:0005515protein binding IPI10521492
    GO:0008270zinc ion binding IDA15236971
    GO:0019787small conjugating protein ligase activity TAS10521492
    GO:0031625ubiquitin protein ligase binding IPI11278816
         
    Find genes that share ontologies with ARIH1           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for ARIH1:
     Increased cell death HMECs cel  Increased cilium length  Increased cilium length after  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARIH1

    miRNA
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    miRTarBase miRNAs that target ARIH1:
    hsa-mir-17-5p (MIRT051051), hsa-mir-425-5p (MIRT039312)

    Block miRNA regulation of human, mouse, rat ARIH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARIH1 (see all 46):
    hsa-miR-642a hsa-miR-429 hsa-miR-548k hsa-let-7a-2* hsa-miR-219-5p hsa-miR-186 hsa-miR-3909 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidARIH1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARIH1

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARIH1
    Addgene plasmids for ARIH1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARIH1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARI1_HUMAN, Q9Y4X5: Cytoplasm. Note=Mainly cytoplasmic
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000151ubiquitin ligase complex TAS10521492
    GO:0005737cytoplasm IDA11278816
    GO:0005829cytosol TAS--

    Find genes that share ontologies with ARIH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARIH1 About    
    See pathways by source

    SuperPathContained pathways About
    1Interferon Signaling
    Interferon Signaling0.59
    ISG15 antiviral mechanism0.42
    Cytokine Signaling in Immune system0.59
    Antiviral mechanism by IFN-stimulated genes0.42


    Find genes that share SuperPaths with ARIH1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for ARIH1
        ISG15 antiviral mechanism


    UniProtKB/Swiss-Prot: ARI1_HUMAN, Q9Y4X5
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARIH1: 

              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARIH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARIH1 (Q9Y4X53 ENSP000003692174) via UniProtKB, MINT, STRING, and/or I2D (see all 36)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EIF4E2O605733, ENSP000002584164I2D: score=3 STRING: ENSP00000258416
    UBE2L6O149333, ENSP000002871564I2D: score=2 STRING: ENSP00000287156
    SIM2Q141903, ENSP000002903994I2D: score=1 STRING: ENSP00000290399
    VAV2P527353, ENSP000003609164I2D: score=1 STRING: ENSP00000360916
    UBE2L3P680363, ENSP000003442594I2D: score=4 STRING: ENSP00000344259
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006511ubiquitin-dependent protein catabolic process TAS10521492
    GO:0016567protein ubiquitination IDA14623119
    GO:0019221cytokine-mediated signaling pathway TAS--

    Find genes that share ontologies with ARIH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARIH1 (ARI1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARIH1 gene: 
    NM_005744.3  

    Unigene Cluster for ARIH1:

    Ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1 (Drosophila)
    Hs.268787  [show with all ESTs]
    Unigene Representative Sequence: NM_005744
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379887(uc002aut.4) ENST00000570085 ENST00000564062 ENST00000567762
    ENST00000561987 ENST00000565950 ENST00000561770 ENST00000566063 ENST00000562891
    ENST00000563310
    miRNA
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    Block miRNA regulation of human, mouse, rat ARIH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARIH1 (see all 46):
    hsa-miR-642a hsa-miR-429 hsa-miR-548k hsa-let-7a-2* hsa-miR-219-5p hsa-miR-186 hsa-miR-3909 hsa-miR-556-3p
    SwitchGear 3'UTR luciferase reporter plasmidARIH1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARIH1
    Clone
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    GenScript: all cDNA clones in your preferred vector: ARIH1 (NM_005744)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARIH1
    Addgene plasmids for ARIH1 
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    OriGene qSTAR qPCR primer pairs in human, mouse for ARIH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARIH1
      QuantiTect SYBR Green Assays in human, mouse, rat ARIH1
      QuantiFast Probe-based Assays in human, mouse, rat ARIH1

    Additional mRNA sequence: 

    AB014774.1 AB209432.1 AF072832.1 AJ009771.1 AJ130976.1 AJ243190.1 AK000336.1 AK312715.1 
    AL117650.1 BC051877.1 

    14 DOTS entries:

    DT.444399  DT.100814845  DT.100684898  DT.40121401  DT.92443023  DT.95276343  DT.100821516  DT.95308543 
    DT.91699068  DT.95276339  DT.95276340  DT.95276345  DT.92443030  DT.97769697 

    Selected AceView cDNA sequences (see all 374):

    N62064 BG939691 BG576711 AW664178 AW237235 AI277671 AV682399 W96313 
    BU183206 BM353676 AL117650 BG392584 BU618529 AA652316 AA708482 AW614320 
    BM689940 BU621104 BF003095 AW130521 BQ014906 AI383073 CF529763 BF115880 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARIH1    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c ^ 15a · 15b
    SP1:                                            -                 -                       -                 -                           
    SP2:                                                                                      -                                             
    SP3:                                                                                                        -                           
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for ARIH1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARIH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTAGGAACT
    ARIH1 Expression
    About this image


    ARIH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ARIH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARIH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268787

    UniProtKB/Swiss-Prot: ARI1_HUMAN, Q9Y4X5
    Tissue specificity: Widely expressed

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARIH1: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for ARIH1
    OriGene qSTAR qPCR primer pairs in human, mouse for ARIH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARIH1
    QuantiTect SYBR Green Assays in human, mouse, rat ARIH1
    QuantiFast Probe-based Assays in human, mouse, rat ARIH1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARIH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARIH1 gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arih11 , 5 ariadne ubiquitin-conjugating enzyme E2 binding protein more1, 5 95.56(n)1
    99.28(a)1
      9 (32.01 cM)5
    238061  NM_019927.21  NP_064311.21 
     593882585 
    chicken
    (Gallus gallus)
    Aves ARIH11 ariadne homolog, ubiquitin-conjugating enzyme E2 binding more 90.83(n)
    100(a)
      415319  NM_001030387.1  NP_001025558.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARIH16
    ariadne RBR E3 ubiquitin protein ligase 1
    96(a)
    1 ↔ 1
    GL343872.1(78162-97020)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.166412 Xenopus laevis transcribed sequence with strong similarity more 83.08(n)    BU899532.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa18d012 wufa18d01 81.25(n)   327005  BC057523.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta ari-11 , 3 ubiquitin-protein ligase3
    ariadne1
    70(a)
    (best of 2)3
    65.72(n)1
    70.81(a)1
      1 16F73
    327961  NM_167610.41  NP_728145.11 
    worm
    (Caenorhabditis elegans)
    Secernentea C27A12.83   -- 55(a)
    (best of 3)
      I(6066989-6069088)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes (YKR017C)4 Putative protein of unknown function; contains a RING more   --   11(473349-471694) 853887  NP_012942.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons ARI21 ARI2 46.24(n)
    36.23(a)
      816106  NM_127167.3  NP_179206.2 
    rice
    (Oryza sativa)
    Liliopsida Os03g02335001 Os03g0233500 47.83(n)
    36.61(a)
      4332164  NM_001056009.1  NP_001049474.1 


    ENSEMBL Gene Tree for ARIH1 (if available)
    TreeFam Gene Tree for ARIH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARIH1 gene
    ANKIB12  ARIH22  RNF19B2  RNF144A2  RNF144B2  RNF19A2  
    Selected SIMAP similar genes for ARIH1 using alignment to 4 protein entries:     ARI1_HUMAN (see all proteins) (see all similar genes):
    ARL6IP5    KIAA1651    ADCK1    TNNT1    pp12301    AARSD1
    EEF1E1    IDNK    LINC00999    VPS33A    FLJ00047    ZNF257
    CDK10    COQ5    DYNC2LI1    EIF3K    NDC80    NLRC5

    Find genes that share paralogs with ARIH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARIH1 (see all 1985)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs347768181,2
    C--49695240(+) AATAA-/T/TT  
            
    TTTTT
    1 -- int10--------
    rs798101741,2
    F--72764680(+) GAAAAG/CAAAGG 1 -- us2k11Minor allele frequency- C:0.03NA 120
    rs2013201851,2
    --72764686(+) AAGGT-/GAGGC 
            
    GAGGC
    1 -- us2k10--------
    rs1813045411,2
    --72764689(+) GGTGAC/GGCAAA 1 -- us2k10--------
    rs1855642191,2
    --72764711(+) TACTGA/CCGAGT 1 -- us2k10--------
    rs285755041,2
    C--72764817(+) TAGAAT/CTGCTA 1 -- us2k1 tfbs32Minor allele frequency- C:0.05WA 120
    rs1463717661,2
    --72764949(+) CTGGCA/CAATAT 1 -- us2k10--------
    rs1384396681,2
    C--72765005(+) GGTGGC/TATGCG 1 -- us2k10--------
    rs2001389181,2
    C--72765047(+) AGGAG-/AAATCG 1 -- us2k10--------
    rs1429428801,2
    --72765191(+) TGAGGC/TTAAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARIH1 (72766667 - 72879692 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ARIH1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv483057CNV Loss15286789
    nsv469704CNV Loss16826518
    nsv428307CNV Gain18775914
    nsv521972CNV Gain19592680
    nsv827384CNV Gain20364138
    dgv755e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): ARIH1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARIH1
    DNA2.0 Custom Variant and Variant Library Synthesis for ARIH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605624    OMIM disorders: --


    Find genes that share disorders with ARIH1           About GenesLikeMe

    Genetic Association Database (GAD): ARIH1

    Export disorders for ARIH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARIH1 gene, integrated from 10 sources (see all 44):
    (articles sorted by number of sources associating them with ARIH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1. (PubMed id 10521492)1, 2, 3 Moynihan T.P.... Robinson P.A. (J. Biol. Chem. 1999)
    2. Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7. (PubMed id 11278816)1, 2, 9 Ardley H.C.... Robinson P.A. (J. Biol. Chem. 2001)
    3. Characterisation of the human and mouse orthologues of the Drosophila ariadne gene. (PubMed id 11124525)1, 2, 9 Tan N.G....Robinson P.A. (Cytogenet. Cell Genet. 2000)
    4. Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins. (PubMed id 10880484)1, 2, 9 Aguilera M.... Ferrus A. (Genetics 2000)
    5. Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase. (PubMed id 24058416)1, 3 Spratt D.E....Shaw G.S. (PLoS ONE 2013)
    6. UBCH7 reactivity profile reveals parkin and HHARI to be RING/HECT hybrids. (PubMed id 21532592)1, 2 Wenzel D.M.... Klevit R.E. (Nature 2011)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Structure of the C-terminal RING finger from a RING-IBR-RING/TRIAD motif reveals a novel zinc-binding domain distinct from a RING. (PubMed id 15236971)1, 2 Capili A.D.... Borden K.L. (J. Mol. Biol. 2004)
    9. Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP. (PubMed id 14623119)1, 2 Tan N.G....Robinson P.A. (FEBS Lett. 2003)
    10. Characterization of 16 novel human genes showing high similarity to yeast sequences. (PubMed id 11124703)1, 2 Stanchi F.... Valle G. (Yeast 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25820 HGNC: 689 AceView: ARIH1 Ensembl:ENSG00000166233 euGenes: HUgn25820
    ECgene: ARIH1 H-InvDB: ARIH1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARIH1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARIH1 gene:
    Search GeneIP for patents involving ARIH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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