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ARID5B Gene

protein-coding   GIFtS: 55
GCID: GC10P063661

AT Rich Interactive Domain 5B (MRF1-Like)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
AT Rich Interactive Domain 5B (MRF1-Like)1 2     MRF1-Like Protein2 3
DESRT2 3 5     AT-Rich Interactive Domain-Containing Protein 5B2
MRF22 3 5     Modulator Recognition Factor 2 (MRF2)2
MRF-22 3     Modulator Recognition Factor 23
ARID Domain-Containing Protein 5B2 3     

External Ids:    HGNC: 173621   Entrez Gene: 841592   Ensembl: ENSG000001503477   OMIM: 6085385   UniProtKB: Q148653   

Export aliases for ARID5B gene to outside databases

Previous GC identifers: GC10P063006 GC10P063327 GC10P057650


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARID5B Gene:
This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded
protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of
target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and
differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with
acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been
observed for this gene. (provided by RefSeq, Sep 2011)

GeneCards Summary for ARID5B Gene:
ARID5B (AT rich interactive domain 5B (MRF1-like)) is a protein-coding gene. Diseases associated with ARID5B include acute lymphoblastic leukemia, childhood, and lymphoblastic leukemia. GO annotations related to this gene include transcription coactivator activity and transcription regulatory region DNA binding. An important paralog of this gene is ARID4B.

UniProtKB/Swiss-Prot: ARI5B_HUMAN, Q14865
Function: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in
adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates
demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates
demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target
genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates
triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to
induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell
differentiation and proliferation. Represses the cytomegalovirus enhancer

Gene Wiki entry for ARID5B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000010.11  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARID5B gene promoter:
         AREB6   CREB   C/EBPbeta   HFH-1   deltaCREB   Chx10   LCR-F1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARID5B promoter sequence
   Search Chromatin IP Primers for ARID5B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARID5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.2   Ensembl cytogenetic band:  10q21.2   HGNC cytogenetic band: 10q11.22

ARID5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARID5B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P063661:  view genomic region     (about GC identifiers)

Start:
63,661,013 bp from pter      End:
63,856,707 bp from pter
Size:
195,695 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARI5B_HUMAN, Q14865 (See protein sequence)
Recommended Name: AT-rich interactive domain-containing protein 5B  
Size: 1188 amino acids; 132375 Da
Sequence caution: Sequence=AAH15120.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=AAH36831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH66345.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAI07801.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=BAB15012.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
2 PDB 3D structures from and Proteopedia for ARID5B:
1IG6 (3D)        2OEH (3D)    
Secondary accessions: B4DLB3 Q05DG6 Q32Q59 Q5VST4 Q6NZ42 Q7Z3M4 Q8N421 Q9H786
Alternative splicing: 3 isoforms:  Q14865-1   Q14865-2   Q14865-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARID5B: NX_Q14865

Explore proteomics data for ARID5B at MOPED

Post-translational modifications: 

  • Methylation at Lys-336 prevents DNA-binding. Demethylation by PHF2 promotes recruitment of the PHF2-ARID5B complex
    to promoters1
  • Ubiquitination2 at Lys74, Lys935, Lys1187
  • Modification sites at PhosphoSitePlus

  • See ARID5B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231567.1  NP_115575.1  

    ENSEMBL proteins: 
     ENSP00000279873   ENSP00000308862  

    ARID5B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR001606 ARID/BRIGHT_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q14865

    ProtoNet protein and cluster: Q14865

    1 Blocks protein domain: IPB001606 ARID (AT-rich interaction domain) protein

    UniProtKB/Swiss-Prot: ARI5B_HUMAN, Q14865
    Domain: The ARID domain mediates the interaction with DNA
    Similarity: Belongs to the ARID5B family
    Similarity: Contains 1 ARID domain


    ARID5B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARI5B_HUMAN, Q14865
    Function: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in
    adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates
    demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates
    demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target
    genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates
    triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to
    induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell
    differentiation and proliferation. Represses the cytomegalovirus enhancer

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA10329386
    GO:0003713contributes to transcription coactivator activity IDA--
    GO:0005515protein binding IPI--
    GO:0044212transcription regulatory region DNA binding IDA--
         
    ARID5B for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for ARID5B:
     Decreased Wnt reporter activit 

         15 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Arid5b):
     adipose tissue  behavior/neurological  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  muscle  renal/urinary system  reproductive system  skeleton 

    ARID5B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ARID5B: Arid5btm1Whit Arid5btm1Pjh

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARID5B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARID5B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARID5B

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for ARID5B (see all 444):
    ABCB5,  ABCE1,  ABHD15,  ACE2,  ADH5,  ADRM1,  AFAP1L1,  AFM,  AGBL4,  AHCYL1

    miRNA
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    hsa-mir-128-3p (MIRT022013), hsa-mir-22-3p (MIRT030642), hsa-mir-101-3p (MIRT027302)

    Block miRNA regulation of human, mouse, rat ARID5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARID5B (see all 92):
    hsa-miR-520e hsa-miR-200a hsa-miR-374a hsa-miR-30d hsa-miR-371-5p hsa-miR-502-3p hsa-miR-30a hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARID5B

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    GenScript: all cDNA clones in your preferred vector: ARID5B (NM_032199)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARID5B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARID5B

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARID5B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARI5B_HUMAN, Q14865: Nucleus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--

    ARID5B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARID5B
    Interactions:

        Search GeneGlobe Interaction Network for ARID5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    Selected Interacting proteins for ARID5B (Q148651, 3 ENSP000002798734) via UniProtKB, MINT, STRING, and/or I2D (see all 22)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    HDAC1Q135471EBI-1210388,EBI-301834
    SUMO2ENSP000004059654STRING: ENSP00000405965
    TADA3ENSP000003076844STRING: ENSP00000307684
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development IEA--
    GO:0001889liver development TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006807nitrogen compound metabolic process ----
    GO:0008584male gonad development IEA--

    ARID5B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARID5B (ARI5B)

    1 PharmGKB related drug/compound annotation for ARID5B gene    About this table
    Drug/compound PharmGKB Annotation
    methotrexateCA  



    ARID5B for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARID5B gene (2 alternative transcripts): 
    NM_001244638.1  NM_032199.2  

    Unigene Cluster for ARID5B:

    AT rich interactive domain 5B (MRF1-like)
    Hs.535297  [show with all ESTs]
    Unigene Representative Sequence: NM_032199
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279873(uc010qil.2 uc001jlt.2 uc001jlu.2) ENST00000309334

    miRNA
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    Block miRNA regulation of human, mouse, rat ARID5B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARID5B (see all 92):
    hsa-miR-520e hsa-miR-200a hsa-miR-374a hsa-miR-30d hsa-miR-371-5p hsa-miR-502-3p hsa-miR-30a hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: ARID5B (NM_032199)
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      QuantiTect SYBR Green Assays in human, mouse, rat ARID5B
      QuantiFast Probe-based Assays in human, mouse, rat ARID5B

    Additional mRNA sequence: 

    AK024803.1 AK123882.1 AK296921.1 AL049471.1 BC015120.1 BC017404.1 BC036831.1 BC056680.1 
    BC066345.1 BC107800.1 BX537690.1 BX641020.1 BX648835.1 M73837.1 

    12 DOTS entries:

    DT.101982328  DT.100692826  DT.95290130  DT.95181287  DT.121214966  DT.97867880  DT.121214907  DT.86859438 
    DT.95168552  DT.97783432  DT.121215009  DT.95103441 

    2 AceView cDNA sequences:

    BE646625 AI538419 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARID5B (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
    SP1:                    -                 -     -                 -                                         -                           
    SP2:                                                              -                                         -                           
    SP3:                                                                                                        -                           
    SP4:                                                                                                                                    
    SP5:                    -     -     -     -     -                                                                                       


    ECgene alternative splicing isoforms for ARID5B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARID5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCAGTGAT
    ARID5B Expression
    About this image


    ARID5B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Fibroblasts
             Detroit 551
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Limb (Muscoskeletal System)
             Prechondrocytic Mesenchymal Cells Zeugopod
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
    ARID5B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARID5B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535297

    UniProtKB/Swiss-Prot: ARI5B_HUMAN, Q14865
    Tissue specificity: Widely expressed, including in liver (at protein level)

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    QuantiFast Probe-based Assays in human, mouse, rat ARID5B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARID5B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARID5B gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arid5b1 , 5 AT rich interactive domain 5B (MRF1-like)1, 5 85.65(n)1
    88.12(a)1
      10 (35.14 cM)5
    713711  NM_023598.21  NP_076087.21 
     680955935 
    chicken
    (Gallus gallus)
    Aves ARID5B1 AT rich interactive domain 5B (MRF1-like) 74.35(n)
    73.87(a)
      423661  NM_001031220.1  NP_001026391.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARID5B6
    AT rich interactive domain 5B (MRF1-like)
    67(a)
    1 ↔ 1
    GL343204.1(3047114-3303204)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.20752 Xenopus laevis transcribed sequence with moderate similarity more 75.31(n)    BQ399325.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005368271 AT-rich interactive domain-containing protein 5B-like 60.46(n)
    58.17(a)
      100536827  XM_003199572.2  XP_003199620.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG344226
    --
    8(a)
    1 → many
    X(18737696-18749891)


    ENSEMBL Gene Tree for ARID5B (if available)
    TreeFam Gene Tree for ARID5B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    Paralogs for ARID5B gene
    ARID4B2  ARID5A2  ARID4A2  

    ARID5B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARID5B (see all 3892)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1466221151,2
    C--57656216(+) ACACT-/GGCCTT 1 -- int10--------
    rs1142487891,2
    C--57656217(+) CACTGC/GCCTTA 1 -- int10--------
    rs30515481,2
    C--57669895(-) TAAAT-/ATGTTTC 1 -- int10--------
    rs558525081,2
    C--57685638(+) ACCTG-/GGTT  
            
    TCCCT
    1 -- int10--------
    rs560266661,2
    C--57685640(+) GTTTC-/CCTTTT
            
    TTTCT
    1 -- int10--------
    rs172897241,2
    C,F--57825458(+) CACAAA/C/GATCTG 2 -- int16NA 130
    rs665096441,2
    C--57825458(+) CACAA-/AG/C/G
            
    ATCTG
    2 -- int11NA 2
    rs57855101,2
    C--57826781(+) CCCCC-/AAAAAA 2 -- int1 trp30--------
    rs664832501,2
    C--57836145(+) AAAGG-/AGGACC 2 -- int10--------
    rs710221031,2
    C--63665204(+) TTTTT-/T/TT  
            
    GGAAT
    1 -- int13NA CSA 6

    HapMap Linkage Disequilibrium report for ARID5B (63661013 - 63856707 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for ARID5B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv988038CNV Deletion20482838
    esv4603CNV Deletion18987735
    esv2737518CNV Deletion23290073
    esv2677112CNV Deletion23128226
    esv2191372CNV Deletion18987734
    esv2737529CNV Deletion23290073
    nsv24157CNV Loss16902084
    nsv831889CNV Loss17160897
    esv34099CNV Loss18971310
    nsv8681CNV Gain18304495

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARID5B
    DNA2.0 Custom Variant and Variant Library Synthesis for ARID5B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608538    OMIM disorders: --

    UniProtKB/Swiss-Prot: ARI5B_HUMAN, Q14865
  • Note=Defects in ARID5B may be a cause of susceptibility to coronary atherosclerosis in the Japanese
    population
  • Leukemia, acute lymphoblastic (ALL) [MIM:613065]: A subtype of acute leukemia, a cancer of the white
    blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The
    malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development.
    The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal
    blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts
    also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphonodes. Note=Disease
    susceptibility is associated with variations affecting the gene represented in this entry

  • Selected diseases for ARID5B (see all 21):    
    About MalaCards
    acute lymphoblastic leukemia, childhood    lymphoblastic leukemia    precursor b-cell acute lymphoblastic leukemia    adenoid cystic carcinoma
    adenoiditis    keratoconus    leukemia    neutropenia
    autoimmune thyroiditis    thrombocytopenia    brain cancer    acute leukemia
    atherosclerosis    systemic lupus erythematosus    lupus erythematosus    rheumatoid arthritis
    arthritis    multiple myeloma    thyroiditis    myeloma


    ARID5B for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARID5B
    Human Genome Epidemiology (HuGE) Navigator: ARID5B (6 documents)

    Export disorders for ARID5B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARID5B gene, integrated from 10 sources (see all 55):
    (articles sorted by number of sources associating them with ARID5B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genetic variations of Mrf-2/ARID5B confer risk of coronary atherosclerosis in the Japanese population. (PubMed id 18612189)1, 2, 4, 9 Wang G.... Nagai R. (Int. Heart J. 2008)
    2. Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood. (PubMed id 20042726)1, 2, 4 Prasad R.B.... Hemminki K. (Blood 2010)
    3. ARID5B SNP rs10821936 is associated with risk of childhood acute lymphoblastic leukemia in blacks and contributes to racial differences in leukemia incidence. (PubMed id 20054350)1, 2, 4 Yang W....Relling M.V. (Leukemia 2010)
    4. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PubMed id 19684603)1, 2, 4 Trevino L.R.... Relling M.V. (Nat. Genet. 2009)
    5. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. (PubMed id 19684604)1, 2, 4 Papaemmanuil E.... Houlston R.S. (Nat. Genet. 2009)
    6. Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA. (PubMed id 11478881)1, 2, 3 Zhu L.... Chen Y. (Biochemistry 2001)
    7. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. (PubMed id 22446963)1, 4 Okada Y....Yamamoto K. (Nat. Genet. 2012)
    8. PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B. (PubMed id 21532585)1, 2 Baba A.... Kato S. (Nat. Cell Biol. 2011)
    9. Replication analysis confirms the association of ARID5B with childhood B-cell acute lymphoblastic leukemia. (PubMed id 20460642)1, 2 Healy J.... Sinnett D. (Haematologica 2010)
    10. Genome-wide association study identifies eight loci associated with blood pressure. (PubMed id 19430483)1, 4 Newton-Cheh C....Munroe P.B. (Nat. Genet. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84159 HGNC: 17362 AceView: ARID5B.1 Ensembl:ENSG00000150347 euGenes: HUgn84159
    ECgene: ARID5B H-InvDB: ARID5B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARID5B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARID5B gene:
    Search GeneIP for patents involving ARID5B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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