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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARID5B Gene

protein-coding   GIFtS: 53
GCID: GC10P063661

AT rich interactive domain 5B (MRF1-like)
 Explore 8 diseases affiliated with
ARID5B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARID5B    

Aliases
for ARID5B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
AT Rich Interactive Domain 5B (MRF1-Like)1 2     MRF1-Like Protein2 3
MRF21 2 3 5     FLJ211501
DESRT2 3 5     AT-Rich Interactive Domain-Containing Protein 5B2
MRF-22 3     Modulator Recognition Factor 2 (MRF2)2
ARID Domain-Containing Protein 5B2 3     Modulator Recognition Factor 23

External Ids:    HGNC: 173621   Entrez Gene: 841592   Ensembl: ENSG000001503477   OMIM: 6085385   UniProtKB: Q148653   

Export aliases for ARID5B gene to outside databases

Previous GC identifers: GC10P063006 GC10P063327 GC10P057650


Summaries
for ARID5B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARID5B:
This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein
forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes
involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of
B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic
leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
(provided by RefSeq, Sep 2011)

UniProtKB/Swiss-Prot: ARI5B_HUMAN, Q14865
Function: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis
and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336,
leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated
'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as
a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by
regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting
that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the
cytomegalovirus enhancer

Gene Wiki entry for ARID5B


Genomic Views
for ARID5B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NC_018921.1  NT_030059.13  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARID5B gene promoter:
         AREB6   CREB   C/EBPbeta   HFH-1   deltaCREB   Chx10   LCR-F1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARID5B promoter sequence
   Search SABiosciences Chromatin IP Primers for ARID5B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARID5B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q21.2   Ensembl cytogenetic band:  10q21.2   HGNC cytogenetic band: 10q11.22

ARID5B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARID5B gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P063661:  view genomic region     (about GC identifiers)

Start:
 63,661,013 bp from pter      End:
 63,856,707 bp from pter
Size:
 195,695 bases      Orientation:
 plus strand

Proteins
for ARID5B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARI5B_HUMAN, Q14865 (See protein sequence)
Recommended Name: AT-rich interactive domain-containing protein 5B  
Size: 1188 amino acids; 132375 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAH15120.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=AAH36831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAH66345.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=AAI07801.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=BAB15012.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
2 PDB 3D structures from and Proteopedia for ARID5B:
1IG6 (3D)        2OEH (3D)    
Secondary accessions: B4DLB3 Q05DG6 Q32Q59 Q5VST4 Q6NZ42 Q7Z3M4 Q8N421 Q9H786
Alternative splicing: 3 isoforms:  Q14865-1   Q14865-2   Q14865-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARID5B: NX_Q14865

Post-translational modifications:

  • Methylation at Lys-336 prevents DNA-binding. Demethylation by PHF2 promotes recruitment of the PHF2-ARID5B complex to
    • promoters1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q14865

    • ARID5B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231567.1  NP_115575.1  

    ENSEMBL proteins: 
     ENSP00000279873   ENSP00000308862  

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    Novus Biologicals ARID5B Protein
    Novus Biologicals ARID5B Lysate
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ARID5B

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--


    ARID5B for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for ARID5B

    Protein Domains /
    Families
    for ARID5B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARID5B for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001606 ARID/BRIGHT_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q14865

    ProtoNet protein and cluster: Q14865

    1 Blocks protein family: IPB001606 ARID (AT-rich interaction domain) protein

    UniProtKB/Swiss-Prot: ARI5B_HUMAN, Q14865
    Domain: The ARID domain mediates the interaction with DNA
    Similarity: Belongs to the ARID5B family
    Similarity: Contains 1 ARID domain


    Function
    for ARID5B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARI5B_HUMAN, Q14865
    Function: Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis
    and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336,
    leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated
    'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as
    a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by
    regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting
    that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the
    cytomegalovirus enhancer

    10/460 SABiosciences Target genes for ARID5B (see all 460):
    ABCB5 ABCE1 ABHD15 ACE2 ADH5 ADRM1 AFAP1L1 AFM AGBL4 AHCYL1

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    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate ARID5B (see all 92):
    hsa-miR-520e hsa-miR-200a hsa-miR-374a hsa-miR-30d hsa-miR-371-5p hsa-miR-502-3p hsa-miR-30a hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene shRNA RFP: ARID5B
    OriGene siRNA: ARID5B
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IDA10329386
    GO:0003713contributes to transcription coactivator activity IDA--
    GO:0005515protein binding IPI--
    GO:0044212transcription regulatory region DNA binding IDA--


    ARID5B for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ARID5B:
     Decreased Wnt reporter activit 

    Animal Models:
         Mouse knock-outs for ARID5B: Arid5btm1Whit Arid5btm1Pjh
         15 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Arid5b):
     adipose tissue  behavior/neurological  cellular  craniofacial  digestive/alimentary 
     endocrine/exocrine gland  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  muscle  renal/urinary system  reproductive system  skeleton 

    ARID5B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARID5B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARID5B

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for ARID5B (Q148653 ENSP000002798734) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SUMO1P631653, ENSP000003760764I2D: score=1 STRING: ENSP00000376076
    SUMO2ENSP000004059654STRING: ENSP00000405965
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5/21 biological process terms (GO ID links to tree view) (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001822kidney development IEA--
    GO:0001889liver development TAS--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006807nitrogen compound metabolic process ----
    GO:0008584male gonad development IEA--


    ARID5B for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARID5B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARID5B for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARID5B
    1 PharmGKB related drug/compound annotation for ARID5B gene
    Drug/compound PharmGKB Annotation
    methotrexateCA  
    About this table

    Search CenterWatch for drugs/clinical trials and news about ARID5B / ARI5B 

    Transcripts
    for ARID5B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARID5B gene (2 alternative transcripts): 
    NM_001244638.1  NM_032199.2  

    Unigene Cluster for ARID5B:

    AT rich interactive domain 5B (MRF1-like)
    Hs.535297  [show with all ESTs]
    Unigene Representative Sequence: NM_032199
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000279873(uc010qil.2 uc001jlt.2 uc001jlu.2) ENST00000309334


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    8/92 QIAGEN miScript miRNA Assays for microRNAs that regulate ARID5B (see all 92):
    hsa-miR-520e hsa-miR-200a hsa-miR-374a hsa-miR-30d hsa-miR-371-5p hsa-miR-502-3p hsa-miR-30a hsa-miR-208b
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARID5B (see all 7)
    OriGene shRNA RFP: ARID5B
    OriGene siRNA: ARID5B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARID5B
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARID5B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARID5B

    Additional cDNA sequence: 

    AK024803.1 AK123882.1 AK296921.1 AL049471.1 BC015120.1 BC017404.1 BC036831.1 BC056680.1 
    BC066345.1 BC107800.1 BX537690.1 BX641020.1 BX648835.1 M73837.1 

    12 DOTS entries:

    DT.101982328  DT.100692826  DT.95290130  DT.95181287  DT.121214966  DT.97867880  DT.121214907  DT.86859438 
    DT.95168552  DT.97783432  DT.121215009  DT.95103441 

    2 AceView cDNA sequences:

    BE646625 AI538419 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ARID5B (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
    SP1:                    -                 -     -                 -                                         -                           
    SP2:                                                              -                                         -                           
    SP3:                                                                                                        -                           
    SP4:                                                                                                                                    
    SP5:                    -     -     -     -     -                                                                                       


    ECgene alternative splicing isoforms for ARID5B

    Expression
    for ARID5B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARID5B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCCCAGTGAT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARID5B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    CD31, CD144 positive cells (Two-step protocol fo...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARID5B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARID5B

    SOURCE GeneReport for Unigene cluster: Hs.535297

    UniProtKB/Swiss-Prot: ARI5B_HUMAN, Q14865
    Tissue specificity: Widely expressed, including in liver (at protein level)

        SABiosciences Custom PCR Arrays for ARID5B
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    In Situ
    Assay Products:     
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    Orthologs
    for ARID5B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARID5B gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Arid5b1 , 5 AT rich interactive domain 5B (MRF1-like)1, 5 85.65(n)1
    88.12(a)1    		   10 (35.14 cM)5
    713711  NM_023598.21  NP_076087.21 
     680955935 
    chicken
    (Gallus gallus)    		 Aves ARID5B1 AT rich interactive domain 5B (MRF1-like) 74.35(n)
    73.87(a)    		   423661  NM_001031220.1  NP_001026391.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARID5B6
    		 --
    		 65(a)
    		 1 ↔ 1
    		 GL343204.1(3047114-3108487)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.20752 Xenopus laevis transcribed sequence with moderate similarity more 75.31(n)    BQ399325.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005368271 AT-rich interactive domain-containing protein 5B-like 57.96(n)
    52.96(a)    		   100536827  XM_003199572.1  XP_003199620.1 
    honey bee
    (Apis mellifera)    		 Insecta --
    		 --
    		 17(a)
    		 1 → many
    		 Group8.5(139954-146640)


    ENSEMBL Gene Tree for ARID5B (if available)
    TreeFam Gene Tree for ARID5B (if available) 

    Paralogs
    for ARID5B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARID5B gene
    ARID4B2  ARID5A2  ARID4A2  

    ARID5B for paralogs           About GeneDecksing



    Genomic Variants
    for ARID5B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3280 NCBI SNPs in ARID5B are shown (see all 3280)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 10 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1123774581,2
    		--57648524(+) GTTTTC/TGACAG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs787776441,2
    		F,--57649185(+) CGGCAG/CCTGGG 1 -- us2k11Minor allele frequency- C:0.02NA 120
    rs780790741,2
    		--57650273(+) CAATCC/AATCTT 1 -- ut511Minor allele frequency- A:0.01WA 118
    rs754671851,2
    		F,--57650295(+) CCACAT/CAGTTT 1 -- ut511Minor allele frequency- C:0.04WA 118
    rs617437051,2
    		F--57651137(+) GACCAG/CCCGGC 2 /T /S mis11Minor allele frequency- C:0.07NS 30
    rs1116074931,2
    		C,--57651471(+) TTGTTC/TAAGGA 1 -- int11Minor allele frequency- T:0.50NA 2
    rs793197061,2
    		--57651510(+) TGTATA/GTGTGT 1 -- int10--------
    rs761587241,2
    		--57651603(+) CGTGTC/TTGGCT 1 -- int10--------
    rs741562741,2
    		C,--57652276(+) CCTACC/AGAGGG 1 -- int14Minor allele frequency- A:0.07WA CSA NA 241
    rs1131944931,2
    		C,--57652983(+) AGGATC/TAAATA 1 -- int11Minor allele frequency- T:0.50NA 2

    HapMap Linkage Disequilibrium report for ARID5B (63661013 - 63856707 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for ARID5B
         2 CNVs: 47941 30508
         4 Indels: 44772 11479 41592 39754

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    Disorders / Diseases
    for ARID5B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARID5B for disorders           About GeneDecksing

    OMIM gene information: 608538    OMIM disorders: --

    UniProtKB/Swiss-Prot: ARI5B_HUMAN, Q14865
  • Note=Defects in ARID5B may be a cause of susceptibility to coronary atherosclerosis in the Japanese population
  • Defects in ARID5B may be a cause of susceptibility to acute lymphoblastic leukemia (ALL) [MIM:613065].
    • Note=ALL is a subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow
    and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts)
    that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in
    a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia
    occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver,
    spleen, and lymphonodes

    8 diseases for ARID5B:    About MalaCards
    acute lymphoblastic leukemia    lymphoblastic leukemia    leukemia    adenoid cystic carcinoma
    adenoiditis    neutropenia    atherosclerosis    carcinoma

    Human Genome Epidemiology (HuGE) Navigator: ARID5B (6 documents)

    Export disorders for ARID5B gene to outside databases

    Publications
    for ARID5B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARID5B gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with ARID5B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA. (PubMed id 11478881)1, 2, 3 Zhu L....Chen Y. (2001)
    2. Genetic variations of mrf-2/arid5b confer risk of coronary atherosclerosis in the Japanese population. (PubMed id 18612189)1, 2, 9 Wang G....Nagai R. (2008)
    3. PKA-dependent regulation of the histone lysine demethylase complex PHF2-ARID5B. (PubMed id 21532585)1, 2 Baba A.... Kato S. (2011)
    4. Replication analysis confirms the association of ARID 5B with childhood B-cell acute lymphoblastic leukemia. (PubMed id 20460642)1, 2 Healy J....Sinnett D. (2010)
    5. Verification of the susceptibility loci on 7p12.2, 10 q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhoo d. (PubMed id 20042726)1, 2 Prasad R.B....Hemminki K. (2010)
    6. ARID5B SNP rs10821936 is associated with risk of chil dhood acute lymphoblastic leukemia in blacks and contributes to racial differen ces in leukemia incidence. (PubMed id 20054350)1, 2 Yang W....Relling M.V. (2010)
    7. Germline genomic variants associated with childhood a cute lymphoblastic leukemia. (PubMed id 19684603)1, 2 TreviA+o L.R....Relling M.V. (2009)
    8. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated wi th risk of childhood acute lymphoblastic leukemia. (PubMed id 19684604)1, 2 Papaemmanuil E....Houlston R.S. (2009)
    9. Determination of the three-dimensional structure of t he Mrf2-DNA complex using paramagnetic spin labeling. (PubMed id 17407261)1, 2 Cai S....Chen Y. (2007)
    10. DNA-binding properties of ARID family proteins. (PubMed id 15640446)1, 2 Patsialou A.... Moran E. (2005)

    External Searches for ARID5B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Genome Databases showing ARID5B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84159 HGNC: 17362 AceView: ARID5B.1 Ensembl:ENSG00000150347 euGenes: HUgn84159
    ECgene: ARID5B H-InvDB: ARID5B

    Other Databases showing ARID5B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARID5B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARID5B Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARID5B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARID5B gene:
    Search GeneIP for patents involving ARID5B

    GeneCards and IP:
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