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Aliases for ARID5B Gene

Aliases for ARID5B Gene

  • AT Rich Interactive Domain 5B (MRF1-Like) 2 3
  • DESRT 3 4 6
  • MRF2 3 4 6
  • ARID Domain-Containing Protein 5B 3 4
  • MRF1-Like Protein 3 4
  • MRF-2 3 4
  • AT-Rich Interactive Domain-Containing Protein 5B 3
  • AT-Rich Interactive Domain 5B (MRF1-Like) 3
  • Modulator Recognition Factor 2 (MRF2) 3
  • Modulator Recognition Factor 2 4

External Ids for ARID5B Gene

Previous GeneCards Identifiers for ARID5B Gene

  • GC10P063006
  • GC10P063327
  • GC10P063661
  • GC10P057650

Summaries for ARID5B Gene

Entrez Gene Summary for ARID5B Gene

  • This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. This gene also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]

GeneCards Summary for ARID5B Gene

ARID5B (AT Rich Interactive Domain 5B (MRF1-Like)) is a Protein Coding gene. Diseases associated with ARID5B include lymphoblastic leukemia. GO annotations related to this gene include transcription coactivator activity and transcription regulatory region DNA binding. An important paralog of this gene is ARID4A.

UniProtKB/Swiss-Prot for ARID5B Gene

  • Transcription coactivator that binds to the 5-AATA[CT]-3 core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated Lys-9 of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.

Gene Wiki entry for ARID5B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID5B Gene

Genomics for ARID5B Gene

Regulatory Elements for ARID5B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARID5B Gene

Start:
61,901,254 bp from pter
End:
62,096,948 bp from pter
Size:
195,695 bases
Orientation:
Plus strand

Genomic View for ARID5B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARID5B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID5B Gene

Proteins for ARID5B Gene

  • Protein details for ARID5B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14865-ARI5B_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 5B
    Protein Accession:
    Q14865
    Secondary Accessions:
    • B4DLB3
    • Q05DG6
    • Q32Q59
    • Q5VST4
    • Q6NZ42
    • Q7Z3M4
    • Q8N421
    • Q9H786

    Protein attributes for ARID5B Gene

    Size:
    1188 amino acids
    Molecular mass:
    132375 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH15120.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAH36831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH66345.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAI07801.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAB15012.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARID5B Gene

    Alternative splice isoforms for ARID5B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARID5B Gene

Proteomics data for ARID5B Gene at MOPED

Post-translational modifications for ARID5B Gene

  • Methylation at Lys-336 prevents DNA-binding. Demethylation by PHF2 promotes recruitment of the PHF2-ARID5B complex to promoters.
  • Ubiquitination at Lys74, Lys935, and Lys1187
  • Modification sites at PhosphoSitePlus

Other Protein References for ARID5B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARID5B Gene

Domains for ARID5B Gene

Protein Domains for ARID5B Gene

Suggested Antigen Peptide Sequences for ARID5B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14865

UniProtKB/Swiss-Prot:

ARI5B_HUMAN :
  • Q14865
Domain:
  • The ARID domain mediates the interaction with DNA
  • Contains 1 ARID domain.
Family:
  • Belongs to the ARID5B family.
genes like me logo Genes that share domains with ARID5B: view

No data available for Gene Families for ARID5B Gene

Function for ARID5B Gene

Molecular function for ARID5B Gene

UniProtKB/Swiss-Prot Function: Transcription coactivator that binds to the 5-AATA[CT]-3 core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated Lys-9 of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer.

Gene Ontology (GO) - Molecular Function for ARID5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 8649988
GO:0001227 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 8649988
GO:0003677 DNA binding IDA 10329386
GO:0003713 contributes_to transcription coactivator activity IDA 21532585
GO:0005515 protein binding IPI 21532585
genes like me logo Genes that share ontologies with ARID5B: view
genes like me logo Genes that share phenotypes with ARID5B: view

Animal Models for ARID5B Gene

MGI Knock Outs for ARID5B:

Animal Model Products

CRISPR Products

miRNA for ARID5B Gene

miRTarBase miRNAs that target ARID5B

Transcription Factor Targeting for ARID5B Gene

Selected GeneGlobe predicted Target genes for ARID5B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARID5B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) and HOMER Transcription for ARID5B Gene

Localization for ARID5B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID5B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID5B Gene COMPARTMENTS Subcellular localization image for ARID5B gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARID5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with ARID5B: view

Pathways for ARID5B Gene

SuperPathways for ARID5B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARID5B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 8649988
GO:0001822 kidney development IEA --
GO:0001889 liver development TAS 21532585
GO:0006325 chromatin organization TAS --
GO:0006351 transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with ARID5B: view

No data available for Pathways by source for ARID5B Gene

Compounds for ARID5B Gene

(1) PharmGKB related drug/compound annotations for ARID5B Gene

Drug/compound Annotation
methotrexate CA
genes like me logo Genes that share compounds with ARID5B: view

Transcripts for ARID5B Gene

mRNA/cDNA for ARID5B Gene

(14) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARID5B Gene

AT rich interactive domain 5B (MRF1-like):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARID5B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARID5B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARID5B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - - - - -
SP2: - -
SP3: -
SP4:
SP5: - - - - -
SP6: - -
SP7:
SP8: - -

Relevant External Links for ARID5B Gene

GeneLoc Exon Structure for
ARID5B
ECgene alternative splicing isoforms for
ARID5B

Expression for ARID5B Gene

mRNA expression in normal human tissues for ARID5B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARID5B Gene

This gene is overexpressed in Muscle - Skeletal (6.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARID5B Gene

SOURCE GeneReport for Unigene cluster for ARID5B Gene Hs.535297

mRNA Expression by UniProt/SwissProt for ARID5B Gene

Q14865-ARI5B_HUMAN
Tissue specificity: Widely expressed, including in liver (at protein level).
genes like me logo Genes that share expressions with ARID5B: view

In Situ Assay Products

Orthologs for ARID5B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARID5B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID5B 35
  • 99.66 (n)
  • 99.83 (a)
ARID5B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARID5B 35
  • 90.81 (n)
  • 92.9 (a)
ARID5B 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID5B 35
  • 85.34 (n)
  • 87.28 (a)
ARID5B 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arid5b 35
  • 85.65 (n)
  • 88.12 (a)
Arid5b 16
Arid5b 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARID5B 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARID5B 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arid5b 35
  • 85.07 (n)
  • 87.74 (a)
chicken
(Gallus gallus)
Aves ARID5B 35
  • 74.35 (n)
  • 73.87 (a)
ARID5B 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARID5B 36
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2075 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arid5b 35
  • 65.54 (n)
  • 62.82 (a)
zebrafish
(Danio rerio)
Actinopterygii ARID5B 36
  • 48 (a)
OneToOne
LOC100536827 35
  • 60.46 (n)
  • 58.17 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG34422 36
  • 8 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SWI1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 16 (a)
OneToMany
Species with no ortholog for ARID5B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARID5B Gene

ENSEMBL:
Gene Tree for ARID5B (if available)
TreeFam:
Gene Tree for ARID5B (if available)

Paralogs for ARID5B Gene

Paralogs for ARID5B Gene

genes like me logo Genes that share paralogs with ARID5B: view

Variants for ARID5B Gene

Sequence variations from dbSNP and Humsavar for ARID5B Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs713240 -- 62,050,693(-) TACAC(A/G)TTTCC intron-variant
rs719730 -- 61,906,567(-) CACAG(C/T)TGGAG intron-variant
rs725529 -- 62,054,311(+) GGTAA(A/T)TGTAA intron-variant
rs869262 -- 61,903,193(-) CTCTG(C/G)CCTCC intron-variant
rs880529 -- 62,017,502(-) TGAAG(A/T)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID5B Gene

Variant ID Type Subtype PubMed ID
nsv8681 CNV Gain 18304495
esv2737518 CNV Deletion 23290073
esv2191372 CNV Deletion 18987734
esv4603 CNV Deletion 18987735
nsv24157 CNV Loss 16902084
esv988038 CNV Deletion 20482838
esv2737529 CNV Deletion 23290073
nsv831889 CNV Loss 17160897
esv34099 CNV Loss 18971310
esv2677112 CNV Deletion 23128226

Relevant External Links for ARID5B Gene

HapMap Linkage Disequilibrium report
ARID5B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID5B Gene

Disorders for ARID5B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARID5B Gene including...

Search for ARID5B Gene in MalaCards »

UniProtKB/Swiss-Prot

ARI5B_HUMAN
  • Note=Defects in ARID5B may be a cause of susceptibility to coronary atherosclerosis in the Japanese population.
  • Leukemia, acute lymphoblastic (ALL) [MIM:613065]: A subtype of acute leukemia, a cancer of the white blood cells. ALL is a malignant disease of bone marrow and the most common malignancy diagnosed in children. The malignant cells are lymphoid precursor cells (lymphoblasts) that are arrested in an early stage of development. The lymphoblasts replace the normal marrow elements, resulting in a marked decrease in the production of normal blood cells. Consequently, anemia, thrombocytopenia, and neutropenia occur to varying degrees. The lymphoblasts also proliferate in organs other than the marrow, particularly the liver, spleen, and lymphonodes. {ECO:0000269 PubMed:19684603, ECO:0000269 PubMed:19684604, ECO:0000269 PubMed:20042726, ECO:0000269 PubMed:20054350, ECO:0000269 PubMed:20189245, ECO:0000269 PubMed:20460642, ECO:0000269 PubMed:21098271}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for ARID5B

Genetic Association Database (GAD)
ARID5B
Human Genome Epidemiology (HuGE) Navigator
ARID5B
genes like me logo Genes that share disorders with ARID5B: view

Publications for ARID5B Gene

  1. Genetic variations of Mrf-2/ARID5B confer risk of coronary atherosclerosis in the Japanese population. (PMID: 18612189) Wang G. … Nagai R. (Int. Heart J. 2008) 3 4 23 48
  2. Dynamics of the Mrf-2 DNA-binding domain free and in complex with DNA. (PMID: 11478881) Zhu L. … Chen Y. (Biochemistry 2001) 2 3 4
  3. Germline genomic variants associated with childhood acute lymphoblastic leukemia. (PMID: 19684603) Trevino L.R. … Relling M.V. (Nat. Genet. 2009) 3 4 48
  4. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. (PMID: 19684604) Papaemmanuil E. … Houlston R.S. (Nat. Genet. 2009) 3 4 48
  5. Verification of the susceptibility loci on 7p12.2, 10q21.2, and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood. (PMID: 20042726) Prasad R.B. … Hemminki K. (Blood 2010) 3 4 48

Products for ARID5B Gene

Sources for ARID5B Gene

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