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Aliases for ARID5A Gene

Aliases for ARID5A Gene

  • AT-Rich Interaction Domain 5A 2 3 5
  • Modulator Recognition Factor 1 2 3 4
  • AT Rich Interactive Domain 5A (MRF1-Like) 2 3
  • ARID Domain-Containing Protein 5A 3 4
  • MRF-1 3 4
  • MRF1 3 4
  • Modulator Recognition Factor I 3
  • RP11-363D14 3
  • RFVG5814 3

External Ids for ARID5A Gene

Previous GeneCards Identifiers for ARID5A Gene

  • GC02P096672
  • GC02P096624
  • GC02P097203
  • GC02P091165

Summaries for ARID5A Gene

Entrez Gene Summary for ARID5A Gene

  • Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARID5A Gene

ARID5A (AT-Rich Interaction Domain 5A) is a Protein Coding gene. GO annotations related to this gene include chromatin binding and transcription regulatory region DNA binding. An important paralog of this gene is ARID5B.

UniProtKB/Swiss-Prot for ARID5A Gene

  • Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID5A Gene

Genomics for ARID5A Gene

Regulatory Elements for ARID5A Gene

Promoters for ARID5A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARID5A on UCSC Golden Path with GeneCards custom track

Genomic Location for ARID5A Gene

Chromosome:
2
Start:
96,536,727 bp from pter
End:
96,552,638 bp from pter
Size:
15,912 bases
Orientation:
Plus strand

Genomic View for ARID5A Gene

Genes around ARID5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARID5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARID5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID5A Gene

Proteins for ARID5A Gene

  • Protein details for ARID5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03989-ARI5A_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 5A
    Protein Accession:
    Q03989
    Secondary Accessions:
    • Q6NX37

    Protein attributes for ARID5A Gene

    Size:
    594 amino acids
    Molecular mass:
    64074 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36325.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ARID5A Gene

Proteomics data for ARID5A Gene at MOPED

Post-translational modifications for ARID5A Gene

  • Ubiquitination at Lys 85
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARID5A Gene

Domains & Families for ARID5A Gene

Gene Families for ARID5A Gene

Protein Domains for ARID5A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARID5A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q03989

UniProtKB/Swiss-Prot:

ARI5A_HUMAN :
  • Contains 1 ARID domain.
Domain:
  • Contains 1 ARID domain.
genes like me logo Genes that share domains with ARID5A: view

Function for ARID5A Gene

Molecular function for ARID5A Gene

UniProtKB/Swiss-Prot Function:
Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison.

Gene Ontology (GO) - Molecular Function for ARID5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ARID5A: view
genes like me logo Genes that share phenotypes with ARID5A: view

Animal Models for ARID5A Gene

MGI Knock Outs for ARID5A:

Animal Model Products

CRISPR Products

miRNA for ARID5A Gene

miRTarBase miRNAs that target ARID5A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARID5A Gene

Localization for ARID5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID5A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID5A Gene COMPARTMENTS Subcellular localization image for ARID5A gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for ARID5A Gene

Pathways & Interactions for ARID5A Gene

SuperPathways for ARID5A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARID5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated TAS 15640446
genes like me logo Genes that share ontologies with ARID5A: view

No data available for Pathways by source and SIGNOR curated interactions for ARID5A Gene

Drugs & Compounds for ARID5A Gene

No Compound Related Data Available

Transcripts for ARID5A Gene

Unigene Clusters for ARID5A Gene

AT rich interactive domain 5A (MRF1-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID5A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - -
SP7: - - - -
SP8: - - - -
SP9: - -
SP10: -
SP11: - - -

Relevant External Links for ARID5A Gene

GeneLoc Exon Structure for
ARID5A
ECgene alternative splicing isoforms for
ARID5A

Expression for ARID5A Gene

mRNA expression in normal human tissues for ARID5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARID5A Gene

This gene is overexpressed in Whole Blood (x9.3).

Protein differential expression in normal tissues from HIPED for ARID5A Gene

This gene is overexpressed in Plasma (59.3) and Adipocyte (9.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARID5A Gene



SOURCE GeneReport for Unigene cluster for ARID5A Gene Hs.920

genes like me logo Genes that share expression patterns with ARID5A: view

Protein tissue co-expression partners for ARID5A Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARID5A Gene

Orthologs for ARID5A Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID5A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARID5A 35
  • 84.89 (n)
  • 79.9 (a)
ARID5A 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID5A 35
  • 86.64 (n)
  • 84.51 (a)
ARID5A 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arid5a 35
  • 80.46 (n)
  • 78.12 (a)
Arid5a 16
Arid5a 36
  • 77 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARID5A 35
  • 96.35 (n)
  • 95.45 (a)
ARID5A 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arid5a 35
  • 78.3 (n)
  • 74.94 (a)
oppossum
(Monodelphis domestica)
Mammalia ARID5A 36
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARID5A 35
  • 58.74 (n)
  • 47.3 (a)
ARID5A 36
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARID5A 36
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arid5a 36
  • 28 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34422 36
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 17 (a)
OneToMany
Species with no ortholog for ARID5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARID5A Gene

ENSEMBL:
Gene Tree for ARID5A (if available)
TreeFam:
Gene Tree for ARID5A (if available)

Paralogs for ARID5A Gene

Paralogs for ARID5A Gene

genes like me logo Genes that share paralogs with ARID5A: view

Variants for ARID5A Gene

Sequence variations from dbSNP and Humsavar for ARID5A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs749027 -- 96,537,400(+) GTAGG(A/C)TCCAC intron-variant, upstream-variant-2KB
rs1011040 -- 96,547,018(+) GATAG(C/T)TGGAG intron-variant
rs1866445 -- 96,537,487(+) CCCTT(C/T)TCTCT intron-variant, upstream-variant-2KB
rs1866446 -- 96,542,006(+) CACCA(C/T)GCAGG intron-variant
rs2278563 -- 96,546,956(+) AACCC(C/T)GGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID5A Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
esv2720413 CNV Deletion 23290073

Variation tolerance for ARID5A Gene

Residual Variation Intolerance Score: 80.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.30; 41.07% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARID5A Gene

HapMap Linkage Disequilibrium report
ARID5A
Human Gene Mutation Database (HGMD)
ARID5A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID5A Gene

Disorders for ARID5A Gene

Relevant External Links for ARID5A

Human Genome Epidemiology (HuGE) Navigator
ARID5A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARID5A

No disorders were found for ARID5A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARID5A Gene

Publications for ARID5A Gene

  1. Repression by a differentiation-specific factor of the human cytomegalovirus enhancer. (PMID: 8649988) Huang T.H. … Itakura K. (Nucleic Acids Res. 1996) 2 3 4 67
  2. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. AT-rich-interactive domain-containing protein 5A functions as a negative regulator of retinoic acid receptor-related orphan nuclear receptor I^t-induced Th17 cell differentiation. (PMID: 24782182) Saito Y. … Nakajima H. ( 2014) 3
  5. Development and application of a DNA microarray-based yeast two-hybrid system. (PMID: 23275563) Suter B. … Wanker E.E. (Nucleic Acids Res. 2013) 3

Products for ARID5A Gene

Sources for ARID5A Gene

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