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Aliases for ARID5A Gene

Aliases for ARID5A Gene

  • AT Rich Interactive Domain 5A (MRF1-Like) 2 3
  • Modulator Recognition Factor 1 2 3 4
  • MRF1 3 4 6
  • ARID Domain-Containing Protein 5A 3 4
  • MRF-1 3 4
  • AT-Rich Interactive Domain-Containing Protein 5A 3
  • Modulator Recognition Factor I 3
  • RP11-363D14 3
  • RFVG5814 3

External Ids for ARID5A Gene

Summaries for ARID5A Gene

Entrez Gene Summary for ARID5A Gene

  • Members of the ARID protein family, including ARID5A, have diverse functions but all appear to play important roles in development, tissue-specific gene expression, and regulation of cell growth (Patsialou et al., 2005 [PubMed 15640446]).[supplied by OMIM, Mar 2008]

GeneCards Summary for ARID5A Gene

ARID5A (AT Rich Interactive Domain 5A (MRF1-Like)) is a Protein Coding gene. Diseases associated with ARID5A include alcohol dependence. GO annotations related to this gene include chromatin binding and transcription factor binding. An important paralog of this gene is ARID4A.

UniProtKB/Swiss-Prot for ARID5A Gene

  • Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID5A Gene

Genomics for ARID5A Gene

Genomic Location for ARID5A Gene

Start:
96,536,727 bp from pter
End:
96,552,638 bp from pter
Size:
15,912 bases
Orientation:
Plus strand

Genomic View for ARID5A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARID5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID5A Gene

Regulatory Elements for ARID5A Gene

Proteins for ARID5A Gene

  • Protein details for ARID5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q03989-ARI5A_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 5A
    Protein Accession:
    Q03989
    Secondary Accessions:
    • Q6NX37

    Protein attributes for ARID5A Gene

    Size:
    594 amino acids
    Molecular mass:
    64074 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA36325.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for ARID5A Gene

Proteomics data for ARID5A Gene at MOPED

Post-translational modifications for ARID5A Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys85

Other Protein References for ARID5A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARID5A Gene

Domains for ARID5A Gene

Protein Domains for ARID5A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

ARI5A_HUMAN
Domain:
  • Contains 1 ARID domain.:
    • Q03989
genes like me logo Genes that share domains with ARID5A: view

No data available for Gene Families for ARID5A Gene

Function for ARID5A Gene

Molecular function for ARID5A Gene

UniProtKB/Swiss-Prot Function: Binds to AT-rich stretches in the modulator region upstream of the human cytomegalovirus major intermediate early gene enhancer. May act as repressor and down-regulate enhancer-dependent gene expressison.

Gene Ontology (GO) - Molecular Function for ARID5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding TAS 15640446
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding IPI 16713569
GO:0008134 transcription factor binding IEA --
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ARID5A: view

Phenotypes for ARID5A Gene

genes like me logo Genes that share phenotypes with ARID5A: view

Animal Models for ARID5A Gene

MGI Knock Outs for ARID5A:

miRNA for ARID5A Gene

miRTarBase miRNAs that target ARID5A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARID5A Gene

Localization for ARID5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID5A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID5A Gene COMPARTMENTS Subcellular localization image for ARID5A gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for ARID5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with ARID5A: view

Pathways for ARID5A Gene

SuperPathways for ARID5A Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARID5A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002062 chondrocyte differentiation IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0035066 positive regulation of histone acetylation IEA --
GO:0045892 negative regulation of transcription, DNA-templated TAS 15640446
genes like me logo Genes that share ontologies with ARID5A: view

No data available for Pathways by source for ARID5A Gene

Transcripts for ARID5A Gene

Unigene Clusters for ARID5A Gene

AT rich interactive domain 5A (MRF1-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID5A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b · 10c · 10d · 10e
SP1: - - - -
SP2: - - -
SP3: - - - - -
SP4: - - -
SP5: - - - - -
SP6: - -
SP7: - - - -
SP8: - - - -
SP9: - -
SP10: -
SP11: - - -

Relevant External Links for ARID5A Gene

GeneLoc Exon Structure for
ARID5A
ECgene alternative splicing isoforms for
ARID5A

Expression for ARID5A Gene

mRNA expression in normal human tissues for ARID5A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARID5A Gene

This gene is overexpressed in Whole Blood (9.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ARID5A Gene

SOURCE GeneReport for Unigene cluster for ARID5A Gene Hs.920

genes like me logo Genes that share expressions with ARID5A: view

Orthologs for ARID5A Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID5A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID5A 36
  • 96.35 (n)
  • 95.45 (a)
ARID5A 37
  • 82 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARID5A 36
  • 84.89 (n)
  • 79.9 (a)
ARID5A 37
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID5A 36
  • 86.64 (n)
  • 84.51 (a)
ARID5A 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arid5a 36
  • 80.46 (n)
  • 78.12 (a)
Arid5a 16
Arid5a 37
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARID5A 37
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arid5a 36
  • 78.3 (n)
  • 74.94 (a)
chicken
(Gallus gallus)
Aves ARID5A 36
  • 58.74 (n)
  • 47.3 (a)
ARID5A 37
  • 98 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARID5A 37
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arid5a 37
  • 28 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34422 37
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 17 (a)
OneToMany
Species with no ortholog for ARID5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARID5A Gene

ENSEMBL:
Gene Tree for ARID5A (if available)
TreeFam:
Gene Tree for ARID5A (if available)

Paralogs for ARID5A Gene

Paralogs for ARID5A Gene

genes like me logo Genes that share paralogs with ARID5A: view

Variants for ARID5A Gene

Sequence variations from dbSNP and Humsavar for ARID5A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1011040 -- 96,547,018(+) GATAG(C/T)TGGAG intron-variant
rs1866446 -- 96,542,006(+) CACCA(C/T)GCAGG intron-variant
rs2278563 -- 96,546,956(+) AACCC(C/T)GGCCT intron-variant
rs2438711 -- 96,548,864(+) CCCCA(C/G)GGCAC intron-variant
rs2464915 -- 96,545,730(+) GTGGG(C/T)GGATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID5A Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
esv2720413 CNV Deletion 23290073

Relevant External Links for ARID5A Gene

HapMap Linkage Disequilibrium report
ARID5A
Human Gene Mutation Database (HGMD)
ARID5A

Disorders for ARID5A Gene

(1) MalaCards Diseases for ARID5A Gene

Search for ARID5A Gene in MalaCards »

(1) University of Copenhagen DISEASES for ARID5A Gene

Relevant External Links for ARID5A

Human Genome Epidemiology (HuGE) Navigator
ARID5A
genes like me logo Genes that share disorders with ARID5A: view

No data available for UniProtKB/Swiss-Prot for ARID5A Gene

Publications for ARID5A Gene

  1. Repression by a differentiation-specific factor of the human cytomegalovirus enhancer. (PMID: 8649988) Huang T.H. … Itakura K. (Nucleic Acids Res. 1996) 2 3 4
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3
  5. DNA-binding properties of ARID family proteins. (PMID: 15640446) Patsialou A. … Moran E. (Nucleic Acids Res. 2005) 3

Products for ARID5A Gene

Sources for ARID5A Gene

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