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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARID4B Gene

protein-coding   GIFtS: 57
GCID: GC01M235295

AT rich interactive domain 4B (RBP1-like)

(Previous names: retinoblastoma binding protein 1-like 1, AT rich interactive...)
(Previous symbol: RBP1L1)
 Explore 9 diseases affiliated with
ARID4B via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARID4B    

Aliases
for ARID4B gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
AT Rich Interactive Domain 4B (RBP1-Like)1 2     180 KDa Sin3-Associated Polypeptide2 3
BRCAA11 2 3 5     ARID Domain-Containing Protein 4B2 3
RBP1L11 2 3 5     AT Rich Interactive Domain 4B (RBP1- Like)1
SAP1801 2 3 5     Retinoblastoma Binding Protein 1-Like 11
RBBP1L12 3 5     AT-Rich Interactive Domain-Containing Protein 4B2
BCAA1 2     Breast Cancer-Associated Antigen 12
Breast Cancer-Associated Antigen BRCAA12 3     Breast Carcinoma-Associated Antigen2
Histone Deacetylase Complex Subunit SAP1802 3     Rb-Binding Protein Homolog2
Retinoblastoma-Binding Protein 1-Like 12 3     SIN3A-Associated Protein 1802
Sin3-Associated Polypeptide P1802 3     

External Ids:    HGNC: 155501   Entrez Gene: 517422   Ensembl: ENSG000000542677   OMIM: 6096965   UniProtKB: Q4LE393   

Export aliases for ARID4B gene to outside databases

Previous GC identifers: GC01M232336 GC01M232371 GC01M231621 GC01M233396 GC01M205778


Summaries
for ARID4B gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARID4B:
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a
subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse
cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The
gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker
associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different
isoforms have been characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39
Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A
corepressor complex or in mediating interactions between the complex and other regulatory complexes

Gene Wiki entry for ARID4B


Genomic Views
for ARID4B gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_167186.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARID4B gene promoter:
         HOXA9B   HOXA9   CUTL1   LCR-F1   YY1   FOXO4   Sox9   IRF-7A   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARID4B promoter sequence
   Search SABiosciences Chromatin IP Primers for ARID4B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARID4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.1-q43   Ensembl cytogenetic band:  1q42.3   HGNC cytogenetic band: 1q42.1-q43

ARID4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARID4B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M235295:  view genomic region     (about GC identifiers)

Start:
 235,294,949 bp from pter      End:
 235,491,534 bp from pter
Size:
 196,586 bases      Orientation:
 minus strand

Proteins
for ARID4B gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39 (See protein sequence)
Recommended Name: AT-rich interactive domain-containing protein 4B  
Size: 1312 amino acids; 147809 Da
Subunit: Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2
Subcellular location: Nucleus (By similarity). Cytoplasm. Note=Cytoplasmic in breast cancer cells
Sequence caution: Sequence=AAD41239.1; Type=Frameshift; Positions=859, 869, 1287, 1311; Sequence=AAF23433.3;
Type=Frameshift; Positions=1287, 1311; Sequence=BAB14428.1; Type=Erroneous initiation; Sequence=BAE06114.1;
Type=Erroneous initiation; Sequence=CAI13751.1; Type=Erroneous gene model prediction;
Secondary accessions: A1L465 Q3MHV4 Q5HY99 Q5T2C2 Q5T2C3 Q5T2C4 Q5T2C5 Q5T2C6 Q6P600 Q86UX1 Q86WR4
Q9H915 Q9NYU3 Q9NZB6 Q9NZG4 Q9P2W4 Q9UF62 Q9Y6E1
Alternative splicing: 4 isoforms:  Q4LE39-1   Q4LE39-2   Q4LE39-3   Q4LE39-4   

Explore the universe of human proteins at neXtProt for ARID4B: NX_Q4LE39

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q4LE39

    • ARID4B Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193723.1  NP_057458.4  NP_112739.2  

    ENSEMBL proteins: 
     ENSP00000420620   ENSP00000264184   ENSP00000355562   ENSP00000394663   ENSP00000416063  
     ENSP00000391497   ENSP00000264183  

    Human Recombinant Protein Products: 
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    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ARID4B

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--


    ARID4B for ontologies           About GeneDecksing



    ARID4B Antibody Products: 
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    Uscn Antibodies for ARID4B
    ThermoFisher Antibodies for ARID4B

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    Uscn ELISAs and CLIAs for ARID4B

    Protein Domains /
    Families
    for ARID4B gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARID4B for domains           About GeneDecksing

    5/6 InterPro domains/families (see all 6):
     IPR000953 Chromo_domain/shadow
     IPR016197 Chromodomain-like
     IPR025995 Tudor-knot
     IPR002999 Tudor
     IPR001606 ARID/BRIGHT_DNA-bd

    Graphical View of Domain Structure for InterPro Entry Q4LE39

    ProtoNet protein and cluster: Q4LE39

    4 Blocks protein families:
    IPB000953 Chromo domain
    IPB001606 ARID (AT-rich interaction domain) protein
    IPB002999 Tudor domain
    IPB012603 RBB1NT


    UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39
    Domain: The C-terminus mediates interaction with mSin3A corepressor complex
    Domain: The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms
    Domain: The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA
    Similarity: Contains 1 ARID domain


    Function
    for ARID4B gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39
    Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A
    corepressor complex or in mediating interactions between the complex and other regulatory complexes

    miRNA
    Products:            		miRTarBase miRNAs that target ARID4B:
    hsa-mir-92a (MIRT004089), hsa-mir-20b (MIRT004072), hsa-mir-106a (MIRT004028), hsa-mir-19b (MIRT004065)

    OriGene 3'-UTR Clone (see all 2): ARID4B
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARID4B
    8/114 QIAGEN miScript miRNA Assays for microRNAs that regulate ARID4B (see all 114):
    hsa-miR-3194-5p hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-199a-3p hsa-miR-106a hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: ARID4B 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARID4B (see all 7)
    OriGene shRNA RFP: ARID4B
    OriGene siRNA: ARID4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARID4B

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARID4B

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARID4B (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): ARID4B (NM_001206794)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARID4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARID4B 

    Cell Line
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    Search LifeMap BioReagents cell lines for ARID4B

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARID4B

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--


    ARID4B for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ARID4B:
     Decreased POU5F1-GFP protein e  Increased G1 DNA content 

    Animal Models:
         Mouse knock-out Arid4btm1Alb for ARID4B
         13 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Arid4b):
     cardiovascular system  cellular  growth/size  hematopoietic system  homeostasis/metabolism 
     immune system  liver/biliary system  mortality/aging  renal/urinary system  reproductive system 
     respiratory system  skeleton  tumorigenesis 

    ARID4B for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARID4B gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Transcription_Sin3 and NuRD in transcription regulation
    		Transcription_Sin3 and NuRD in transcription regulation1.00
    		Transcription Sin3 and NuRD in transcription regulation0.96

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for ARID4B
        Transcription Sin3 and NuRD in transcription regulation


    1 GeneGo (Thomson Reuters) Pathway for ARID4B
        Transcription Sin3 and NuRD in transcription regulation



    ARID4B for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARID4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/14 Interacting proteins for ARID4B (Q4LE391, 3 ENSP000002641834) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS1P149211, 3EBI-2680990,EBI-913209 I2D: score=1 
    RANBP2P497923, ENSP000002831954I2D: score=3 STRING: ENSP00000283195
    ARID4AP293743, ENSP000003476024I2D: score=1 STRING: ENSP00000347602
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008150biological_process ND--


    ARID4B for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARID4B gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARID4B
    Search CenterWatch for drugs/clinical trials and news about ARID4B / ARI4B 

    Transcripts
    for ARID4B gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARID4B gene (3 alternative transcripts): 
    NM_001206794.1  NM_016374.5  NM_031371.3  

    Unigene Cluster for ARID4B:

    AT rich interactive domain 4B (RBP1-like)
    Hs.575782  [show with all ESTs]
    Unigene Representative Sequence: NM_016374
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474953(uc001hwp.3) ENST00000349213(uc001hwr.3) ENST00000366603(uc021pks.1)
    ENST00000421364 ENST00000474401 ENST00000491632(uc001hws.4) ENST00000444620
    ENST00000494543 ENST00000471257(uc001hwt.4) ENST00000418304 ENST00000466653(uc001hwu.1)
    ENST00000462969 ENST00000264183(uc001hwq.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): ARID4B
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARID4B
    8/114 QIAGEN miScript miRNA Assays for microRNAs that regulate ARID4B (see all 114):
    hsa-miR-3194-5p hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-199a-3p hsa-miR-106a hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmid: ARID4B 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARID4B (see all 7)
    OriGene shRNA RFP: ARID4B
    OriGene siRNA: ARID4B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARID4B
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARID4B (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARID4B (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 3): ARID4B (NM_001206794)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARID4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARID4B 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARID4B
    Browse OriGene validated miRNA SYBR primer pairs
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARID4B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARID4B

    Additional cDNA sequence: 

    AB210032.1 AF083249.1 AF208045.2 AF214114.2 AF227899.1 AK023144.1 AL133594.1 AY220790.1 
    BC017800.1 BC048959.1 BC062536.1 BC104632.1 BC130418.1 BC143719.1 BX648820.1 

    19 DOTS entries:

    DT.97807555  DT.100791932  DT.95174930  DT.95369910  DT.95174928  DT.101983160  DT.444260  DT.100791933 
    DT.95174931  DT.97786083  DT.315604  DT.92016831  DT.100665761  DT.121438798  DT.40125838  DT.91743274 
    DT.95174935  DT.95237769  DT.95369908 

    24/393 AceView cDNA sequences (see all 393):

    BX501164 CA306263 AI184478 T28187 AI860543 BQ929526 AW327787 CR622969 
    AW590370 BU608657 AU131136 AK023144 AI263057 AA399016 AA907555 BQ640519 
    AA249163 AI632699 AL133010 NM_031371 AU139233 F33250 CD250999 BM995796 

    GeneLoc Exon Structure


    Expression
    for ARID4B gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARID4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTTTCTTTGT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARID4B expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    LungLung BudLung
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

    See ARID4B Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARID4B

    SOURCE GeneReport for Unigene cluster: Hs.575782

    UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39
    Tissue specificity: Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers.
    Expressed at low levels in the thymus, prostate and ovary

        SABiosciences Custom PCR Arrays for ARID4B
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARID4B
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARID4B
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARID4B
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARID4B
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARID4B

    Orthologs
    for ARID4B gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARID4B gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARID4B1 AT rich interactive domain 4B (RBP1-like) 78.57(n)
    79.8(a)    		   425840  XM_003640986.1  XP_003641034.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARID4B6
    		 --
    		 77(a)
    		 1 ↔ 1
    		 1(219569474-219627846)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia AL898445.12   -- 78.52(n)    AL898445.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005379231 AT-rich interactive domain-containing protein 4B-like 59.7(n)
    58.91(a)    		   100537923  XM_003199758.1  XP_003199806.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG344221 CG34422 43.71(n)
    37.89(a)    		   32877  NM_133102.2  NP_573330.2 
    worm
    (Caenorhabditis elegans)    		 Secernentea arid-16
    		 --
    		 12(a)
    		 1 → many
    		 V(186306-200687)


    ENSEMBL Gene Tree for ARID4B (if available)
    TreeFam Gene Tree for ARID4B (if available) 

    Paralogs
    for ARID4B gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARID4B gene
    ARID5A2  ARID4A2  ARID5B2  
    1 SIMAP similar gene for ARID4B using alignment to 4 protein entries:     ARI4B_HUMAN (see all proteins):
    ARID4A

    ARID4B for paralogs           About GeneDecksing



    Genomic Variants
    for ARID4B gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2645 NCBI SNPs in ARID4B are shown (see all 2645)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1874111621,2
    		--235329721(+) ATAAAA/TGAATG 3 -- ds50010--------
    rs1923132361,2
    		--235329739(+) TGGGTA/GTGTTG 3 -- ds50010--------
    rs1456534561,2
    		--235329938(+) AACCCA/GGGAGA 3 -- ds50010--------
    rs356525651,2
    		C--235330014(+) TGTCC-/AAAAAA 3 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1123398651,2
    		--235330338(+) TTTTTC/TCTTCA 3 -- ut311Minor allele frequency- T:0.50CSA 2
    rs111951,2
    		C,F,H--235330430(+) AAGCAC/TACACT 3 -- ut31 ese310Minor allele frequency- T:0.01MN NS EA NA 1308
    rs1836785251,2
    		--235330607(+) AACAGA/TCTGTA 3 -- ut310--------
    rs1493145661,2
    		--235330617(+) ACAATA/GAAGTA 3 -- ut310--------
    rs794598391,2
    		C--235331206(+) AGGGCA/CATGAA 3 -- ut310--------
    rs1879383261,2
    		--235331289(+) ATATTC/TGGTTA 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ARID4B (235294949 - 235491534 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for ARID4B
         1 CNV: 48278
         2 Indels: 39698 24105

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ARID4B

    Disorders / Diseases
    for ARID4B gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARID4B for disorders           About GeneDecksing

    OMIM gene information: 609696    OMIM disorders: --

    9 diseases for ARID4B:    About MalaCards
    breast cancer    retinoblastoma    breast carcinoma    motor neuronopathy
    carcinoma    ovarian cancer    schizophrenia    pancreatitis
    prostatitis

    2 Novoseek disease relationships for ARID4B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 45 4 10777059 (1), 16479010 (1), 1646903 (1)
    tumors 0 1 8946837 (1)

    Human Genome Epidemiology (HuGE) Navigator: ARID4B (2 documents)

    Export disorders for ARID4B gene to outside databases

    Publications
    for ARID4B gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARID4B gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with ARID4B)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis. (PubMed id 11481388)1, 2, 3 Cao J.-N.... Irie R. (2001)
    2. Characterization of BRCAA1 and its novel antigen epitope identification. (PubMed id 15247124)1, 2, 9 Cui D....Sarai A. (2004)
    3. Identification and characterization of three new components of the mSin3A corepressor complex. (PubMed id 12724404)1, 2, 9 Fleischer T.C....Ayer D.E. (2003)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Allelic variation and differential expression of the m SIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and m etastasis. (PubMed id 22693453)1 Winter S.F....Hunter K.W. (2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for ARID4B gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
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    Genome Databases showing ARID4B gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51742 HGNC: 15550 AceView: ARID4B Ensembl:ENSG00000054267 euGenes: HUgn51742
    ECgene: ARID4B H-InvDB: ARID4B

    Other Databases showing ARID4B gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARID4B gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARID4B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARID4B Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ARID4B gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARID4B gene:
    Search GeneIP for patents involving ARID4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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