Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARID4B Gene

Aliases for ARID4B Gene

  • AT Rich Interactive Domain 4B (RBP1-Like) 2 3
  • RBBP1L1 3 4 6
  • RBP1L1 3 4 6
  • BRCAA1 3 4 6
  • SAP180 3 4 6
  • Histone Deacetylase Complex Subunit SAP180 3 4
  • Breast Cancer-Associated Antigen BRCAA1 3 4
  • Retinoblastoma-Binding Protein 1-Like 1 3 4
  • 180 KDa Sin3-Associated Polypeptide 3 4
  • ARID Domain-Containing Protein 4B 3 4
  • Sin3-Associated Polypeptide P180 3 4
  • AT-Rich Interactive Domain-Containing Protein 4B 3
  • AT Rich Interactive Domain 4B (RBP1- Like) 2
  • Retinoblastoma Binding Protein 1-Like 1 2
  • Breast Carcinoma-Associated Antigen 3
  • Breast Cancer-Associated Antigen 1 3
  • SIN3A-Associated Protein 180 3
  • Rb-Binding Protein Homolog 3
  • BCAA 3

External Ids for ARID4B Gene

Previous HGNC Symbols for ARID4B Gene

  • RBP1L1

Previous GeneCards Identifiers for ARID4B Gene

  • GC01M232336
  • GC01M232371
  • GC01M231621
  • GC01M233396
  • GC01M235295
  • GC01M205778
  • GC01M235296
  • GC01M235298

Summaries for ARID4B Gene

Entrez Gene Summary for ARID4B Gene

  • This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID4B Gene

ARID4B (AT Rich Interactive Domain 4B (RBP1-Like)) is a Protein Coding gene. Diseases associated with ARID4B include retinoblastoma and breast cancer. Among its related pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation. An important paralog of this gene is ARID4A.

UniProtKB/Swiss-Prot for ARID4B Gene

  • Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Gene Wiki entry for ARID4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID4B Gene

Genomics for ARID4B Gene

Regulatory Elements for ARID4B Gene

Genomic Location for ARID4B Gene

Start:
235,131,634 bp from pter
End:
235,328,219 bp from pter
Size:
196,586 bases
Orientation:
Minus strand

Genomic View for ARID4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARID4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID4B Gene

Proteins for ARID4B Gene

  • Protein details for ARID4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4LE39-ARI4B_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 4B
    Protein Accession:
    Q4LE39
    Secondary Accessions:
    • A1L465
    • Q3MHV4
    • Q5HY99
    • Q5T2C2
    • Q5T2C3
    • Q5T2C4
    • Q5T2C5
    • Q5T2C6
    • Q6P600
    • Q86UX1
    • Q86WR4
    • Q9H915
    • Q9NYU3
    • Q9NZB6
    • Q9NZG4
    • Q9P2W4
    • Q9UF62
    • Q9Y6E1

    Protein attributes for ARID4B Gene

    Size:
    1312 amino acids
    Molecular mass:
    147809 Da
    Quaternary structure:
    • Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.
    SequenceCaution:
    • Sequence=AAD41239.1; Type=Frameshift; Positions=859, 869, 1287, 1311; Evidence={ECO:0000305}; Sequence=AAF23433.3; Type=Frameshift; Positions=1287, 1311; Evidence={ECO:0000305}; Sequence=BAB14428.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE06114.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13751.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARID4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARID4B Gene

Proteomics data for ARID4B Gene at MOPED

Post-translational modifications for ARID4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARID4B Gene

No data available for DME Specific Peptides for ARID4B Gene

Domains for ARID4B Gene

Suggested Antigen Peptide Sequences for ARID4B Gene

Graphical View of Domain Structure for InterPro Entry

Q4LE39

UniProtKB/Swiss-Prot:

ARI4B_HUMAN :
  • Q4LE39
Domain:
  • The C-terminus mediates interaction with mSin3A corepressor complex.
  • The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
  • The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.
  • Contains 1 ARID domain.
genes like me logo Genes that share domains with ARID4B: view

No data available for Gene Families for ARID4B Gene

Function for ARID4B Gene

Molecular function for ARID4B Gene

UniProtKB/Swiss-Prot Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Gene Ontology (GO) - Molecular Function for ARID4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding --
GO:0005515 protein binding IPI 20195357
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ARID4B: view
genes like me logo Genes that share phenotypes with ARID4B: view

Animal Models for ARID4B Gene

MGI Knock Outs for ARID4B:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARID4B Gene

Localization for ARID4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID4B Gene

Nucleus. Cytoplasm. Note=Cytoplasmic in breast cancer cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID4B Gene COMPARTMENTS Subcellular localization image for ARID4B gene
Compartment Confidence
nucleus 3

Gene Ontology (GO) - Cellular Components for ARID4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005622 intracellular --
GO:0005634 nucleus IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARID4B: view

Pathways for ARID4B Gene

genes like me logo Genes that share pathways with ARID4B: view

Pathways by source for ARID4B Gene

1 GeneGo (Thomson Reuters) pathway for ARID4B Gene

Gene Ontology (GO) - Biological Process for ARID4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006349 regulation of gene expression by genetic imprinting IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
genes like me logo Genes that share ontologies with ARID4B: view

Transcripts for ARID4B Gene

Unigene Clusters for ARID4B Gene

AT rich interactive domain 4B (RBP1-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID4B Gene

No ASD Table

Relevant External Links for ARID4B Gene

GeneLoc Exon Structure for
ARID4B
ECgene alternative splicing isoforms for
ARID4B

Expression for ARID4B Gene

mRNA expression in normal human tissues for ARID4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARID4B Gene

SOURCE GeneReport for Unigene cluster for ARID4B Gene Hs.575782

mRNA Expression by UniProt/SwissProt for ARID4B Gene

Q4LE39-ARI4B_HUMAN
Tissue specificity: Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.
genes like me logo Genes that share expressions with ARID4B: view

No data available for mRNA differential expression in normal tissues for ARID4B Gene

Orthologs for ARID4B Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID4B 35
  • 99.67 (n)
  • 99.43 (a)
ARID4B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARID4B 35
  • 90.54 (n)
  • 92.25 (a)
ARID4B 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID4B 35
  • 93.69 (n)
  • 94.7 (a)
ARID4B 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arid4b 35
  • 88.27 (n)
  • 88.73 (a)
Arid4b 16
Arid4b 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARID4B 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 96 (a)
OneToMany
-- 36
  • 70 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia LOC100912163 35
  • 86.15 (n)
  • 87.08 (a)
chicken
(Gallus gallus)
Aves ARID4B 35
  • 79.16 (n)
  • 80.56 (a)
ARID4B 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARID4B 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arid4b 35
  • 68.25 (n)
  • 64.38 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100537923 35
  • 59.47 (n)
  • 59.05 (a)
tomm20a 36
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea arid-1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for ARID4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARID4B Gene

ENSEMBL:
Gene Tree for ARID4B (if available)
TreeFam:
Gene Tree for ARID4B (if available)

Paralogs for ARID4B Gene

Paralogs for ARID4B Gene

Selected SIMAP similar genes for ARID4B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ARID4B: view

Variants for ARID4B Gene

Sequence variations from dbSNP and Humsavar for ARID4B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11195 -- 235,167,115(+) AAGCA(C/T)ACACT utr-variant-3-prime
rs946027 -- 235,182,971(-) CCATC(A/G)TTGGA intron-variant
rs1106515 -- 235,209,495(+) ACCAA(A/C)CAGCA intron-variant
rs1176997 -- 235,174,602(+) tcaag(A/G)ccagc intron-variant
rs1317238 -- 235,294,265(-) AGTAA(C/T)GAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID4B Gene

Variant ID Type Subtype PubMed ID
dgv30n21 CNV Gain 19592680
dgv548n71 CNV Loss 21882294
esv2725307 CNV Deletion 23290073
nsv827453 CNV Loss 20364138
nsv873321 CNV Gain 21882294
esv2725318 CNV Deletion 23290073
esv1108970 CNV Deletion 17803354
esv1314619 CNV Insertion 17803354
esv1721702 CNV Insertion 17803354

Relevant External Links for ARID4B Gene

HapMap Linkage Disequilibrium report
ARID4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID4B Gene

Disorders for ARID4B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ARID4B Gene including...

Search for ARID4B Gene in MalaCards »

(2) Novoseek inferred disease relationships for ARID4B Gene

Disease -log(P) Hits PubMed IDs
breast cancer 45 3
tumors 0 1

Relevant External Links for ARID4B

Genetic Association Database (GAD)
ARID4B
Human Genome Epidemiology (HuGE) Navigator
ARID4B
genes like me logo Genes that share disorders with ARID4B: view

No data available for UniProtKB/Swiss-Prot for ARID4B Gene

Publications for ARID4B Gene

  1. Identification and characterization of three new components of the mSin3A corepressor complex. (PMID: 12724404) Fleischer T.C. … Ayer D.E. (Mol. Cell. Biol. 2003) 3 4 23
  2. Characterization of BRCAA1 and its novel antigen epitope identification. (PMID: 15247124) Cui D. … Sarai A. (Cancer Epidemiol. Biomarkers Prev. 2004) 3 4 23
  3. RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis. (PMID: 11481388) Cao J.-N. … Irie R. (J. Natl. Cancer Inst. 2001) 2 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARID4B Gene

  • antibodies-online peptides for ARID4B
  • antibodies-online antibodies for ARID4B
  • antibodies-online kits for ARID4B

Sources for ARID4B Gene

Back to Top

Content