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ARID4B Gene

protein-coding GIFtS: 57

GC01M233396

AT rich interactive domain 4B (RBP1-like)
(Previous names: retinoblastoma binding protein 1-like 1, AT rich interactive domain 4B (RBP1- like) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RBP1L1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
BCAA ^¹, ²
BRCAA1 ^¹, ², ³, ⁵
DKFZp313M2420 ^²
MGC163290 ^²
OTTHUMP00000037596 ^²
RBBP1L1 ^², ³, ⁵
RBP1L1 ^², ³, ⁵
SAP180 ^¹, ², ³, ⁵

Descriptions
180 kDa Sin3-associated polypeptide ^³
ARID domain-containing protein 4B ^³
AT rich interactive domain 4B ^²
AT rich interactive domain 4B (RBP1- like) ^¹
AT rich interactive domain 4B (RBP1-like) ^²
Breast cancer-associated antigen BRCAA1 ^³
Histone deacetylase complex subunit SAP180 ^³
RBP1-like protein ^²
Rb-binding protein homolog ^²
Retinoblastoma-binding protein 1-like 1 ^², ³
SIN3A-associated protein 180 ^²
Sin3-associated polypeptide p180 ^³
breast cancer-associated antigen 1 ^²
breast carcinoma-associated antigen ^²
retinoblastoma binding protein 1-like 1 ^¹, ²

External Ids
HGNC: 15550¹
Entrez Gene: 51742²
UniProtKB: Q4LE39³
Ensembl: ENSG00000054267⁷

Search outside databases for aliases for ARID4B gene

Previous GC identifers: GC01M232336 GC01M232371 GC01M231621

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for ARID4B:

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The

encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional

corepressor complex, which functions in diverse cellular processes including proliferation,

differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is

recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular

marker associated with a broad range of human malignancies. Alternate transcriptional splice

variants encoding different isoforms have been characterized. [provided by RefSeq]

UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39

Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic

activity of the Sin3A corepressor complex or in mediating interactions between the complex and

other regulatory complexes

Gene Wiki entry for ARID4B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ARID4B gene

Entrez Gene cytogenetic band: 1q42.1-q43 Ensembl cytogenetic band: 1q42.3 HGNC cytogenetic band: 1q42.1-q43

ARID4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M233396: (about GC identifiers)

Start:	233,396,833 bp from pter
End:	233,558,155 bp from pter
Size:	161,323 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.9 NT_004836.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39 (See protein sequence)

Recommended Name: AT-rich interactive domain-containing protein 4B

Size: 1312 amino acids; 147809 Da

Subunit: Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180,

HDAC1 and HDAC2

Subcellular location: Nucleus (By similarity). Cytoplasm. Note=Cytoplasmic in breast cancer cells

Sequence caution: Sequence=AAD41239.1; Type=Frameshift; Positions=859, 869, 1287, 1311;

Sequence=AAF23433.3; Type=Frameshift; Positions=1287, 1311; Sequence=CAI13751.1; Type=Erroneous

gene model prediction;

Secondary accessions: A1L465 Q3MHV4 Q5HY99 Q5T2C2 Q5T2C3 Q5T2C4 Q5T2C5 Q5T2C6 Q6P600 Q86UX1 Q86WR4

Q9H915 Q9NYU3 Q9NZB6 Q9NZG4 Q9P2W4 Q9UF62 Q9Y6E1

Alternative splicing: 4 isoforms: Q4LE39-1 Q4LE39-2 Q4LE39-3 Q4LE39-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_057458.4 NP_112739.2

ENSEMBL proteins:

ENSP00000264183 ENSP00000264184 ENSP00000355562 ENSP00000375729

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (BRCAA1)
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000785	chromatin	IEA	--
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	IEA	--
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

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Antibodies for ARID4B:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ARID4B
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (BRCAA1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ARID4B)
	Novus Biologicals Antibody for ARID4B

Assays for ARID4B:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q4LE39

ProtoNet protein and cluster: Q4LE39

4 Blocks protein families:

IPB000953 Chromo domain

IPB001606 ARID (AT-rich interaction domain) protein

IPB002999 Tudor domain

IPB012603 RBB1NT

UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39

Domain: The C-terminus mediates interaction with mSin3A corepressor complex

Domain: The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms

Domain: The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA

Similarity: Contains 1 ARID domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARID4B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ARID4B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016374

Applied Biosystems Silencer® siRNAs for ARID4B

Sigma-Aldrich siRNA for ARID4B

Sigma-Aldrich shRNA for ARID4B

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_016374
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_016374
untagged cDNA clones in CMV expression vector (see all 2): NM_016374

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016374

UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39

Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic

activity of the Sin3A corepressor complex or in mediating interactions between the complex and

other regulatory complexes

14 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Arid4b):

	cellular	growth/size	hematopoietic system	immune system
lethality-postnatal	lethality-prenatal/perinatal	life span-post-weaning/aging	liver/biliary system	renal/urinary system
reproductive system	respiratory system	skeleton	tumorigenesis

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0003677	DNA binding	IEA	--
GO:0003682	chromatin binding	IEA	--

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(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for ARID4B (Your Favorite Gene powered by Ingenuity)

DNA Methylation and Transcriptional Repression Signaling

GeneDecks ARID4B for the pathways selected above

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5/17 Interacting proteins for ARID4B (ENSP00000264183³) via UniProtKB, MINT, and/or STRING (see all 17 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SUDS3	ENSP00000251152³	STRING (score=.964)
HDAC2	ENSP00000357621³	STRING (score=.942)
HDAC1	ENSP00000362649³	STRING (score=.938)
SIN3A	ENSP00000353622³	STRING (score=.931)
BCKDHB	ENSP00000318351³	STRING (score=.908)

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4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006333	chromatin assembly or disassembly	IEA	--
GO:0006350	transcription	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0008150	biological_process	ND	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
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Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ARID4B

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARID4B)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ARID4B)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_016374

Sigma-Aldrich siRNA for ARID4B

Sigma-Aldrich shRNA for ARID4B

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_016374 NM_031371

REFSEQ mRNAs for ARID4B gene (2 alternative transcripts):

NM_016374.5 NM_031371.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_016374 NM_031371

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_016374
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_016374
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_016374

Additional cDNA sequence:

AB210032.1 AF083249.1 AF208045.2 AF214114.2 AF227899.1 AK023144.1 AL133594.1 AY220790.1

BC017800.1 BC048959.1 BC062536.1 BC104632.1 BC130418.1 BC143719.1 BX648820.1

18 DOTS entries:

DT.97807555 DT.100791932 DT.95174930 DT.95369910 DT.101983160 DT.95174928 DT.444260 DT.100791933

DT.95174931 DT.97786083 DT.315604 DT.92016831 DT.121438798 DT.40125838 DT.91743274 DT.95174935

DT.95237769 DT.95369908

24/393 AceView cDNA sequences (see all 393 ):

AA743290 CB043937 BM728320 BM995796 AA765478 AI632699 BC048959 T94766

AI284462 AA907555 CR622969 AI656542 BU619558 AK023144 CA944809 AV718375

CD250999 AI539819 AI754052 BE893284 CR609536 CR615831 BU609087 AU139233

highest scoring ESTs for ARID4B:

AA399016 AA485078 AA741369 AA766612 AA772654 AA830588 AA838690 AA872530 AF214114 AI040842

Unigene Cluster for ARID4B:

AT rich interactive domain 4B (RBP1-like)

Hs.575782 [show with all ESTs]

Unigene Representative Sequence: NM_016374

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000264183 ENST00000349213 ENST00000366603 ENST00000391856

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ARID4B expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ARID4B

¹ / ² / ³

11 probe-sets matching ARID4B gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
55816_at²^{, 3}	U95-C	1	1.00	1.00	0.87	0.62	AI091806	0.80	0.88	0.84	1
47878_f_at²^{, 3}	U95-B	1	1.00	1.00	0.96	0.99	AI656542	0.60	0.83	0.73	1
63532_at²^{, 3}	U95-C	1	1.00	1.00	-0.03	0.15	H38607	0.80	0.88	0.84	1
63394_at²^{, 3}	U95-C	1	1.00	1.00	0.92	1.44	AI365221	0.80	0.88	0.84	1
74178_at²^{, 3}	U95-E	1	1.00	1.00	0.81	0.96	AA399016	0.80	0.88	0.84	1
223111_x_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BF058966	0.60	0.83	0.73	1
221230_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016374	0.60	0.83	0.73	1
224322_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AB030181	0.20	0.50	0.38	1
223111_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
221230_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
224322_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--

GeneDecks ARID4B for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: TTTTCTTTGT

SOURCE GeneReport for Unigene cluster: Hs.575782
Expression variation in blood from EXPOLDB for ARID4B
UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39
Tissue specificity: Highly expressed in the testis and in breast, lung, colon, pancreatic and
ovarian cancers. Expressed at low levels in the thymus, prostate and ovary

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for ARID4B gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	ARID4B¹	--	AT rich interactive domain 4B (RBP1-like)	93.87(n) 94.81(a)	488959 XM_843623.1 XP_848716.1
chimpanzee (Pan troglodytes)	ARID4B¹	--	AT rich interactive domain 4B (RBP1-like)	99.69(n) 99.62(a)	457835 XM_001154237.1 XP_001154237.1
cow (Bos taurus)	ARID4B¹	--	AT rich interactive domain 4B (RBP1-like)	91.07(n) 92.75(a)	534612 XM_864319.2 XP_869412.1
rat (Rattus norvegicus)	Arid4b¹	--	AT rich interactive domain 4B (Rbp1 like)	87.43(n) 88.65(a)	84481 NM_053421.1 NP_445873.1
mouse (Mus musculus)	Arid4b^{1, 5}	13 (8.00 cM)⁵	AT rich interactive domain 4B (RBP1-like)^{1, 5}	89.3(n)¹ 89.78(a)¹	94246¹ NM_194262.1¹ NP_919238.1¹ AI153796⁵ AI849387⁵ (see all 28)

About this table Species with no ortholog for ARID4B

ENSEMBL Gene Tree for ARID4B

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ARID4B gene

ARID5A² ARID4A² ARID5B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/988 NCBI SNPs in ARID4B are shown (see all 988 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 184)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs11195^1,2	C	233397053(+)	`AAGCAC/TACACT`	2	--	ut3¹ ese³		1		MN	184
	rs4659654^1,2	A,C,F,H	233449811(+)	`TTGTCA/GTCCAG`	2	D/D	syn¹		7		NA EU EA WA	554
	rs12731746^1,2	A,C	233459169(+)	`CTTACC/TTCTTC`	2	E/E	syn¹ trp³		0	--	--	--	--
	rs2093406^1,2	A,C,F,H,O	233438168(+)	`CACTCA/GACTAG`	2	--	int¹		19		EU EA WA NA	3156
	rs2891026^1,2	A,C,F,H,O	233496530(-)	`CAGTGT/GTTTTT`	2	--	int¹		11		EU EA WA NA	970
	rs1933251^1,2	A,C,F,H,O	233517795(-)	`TGTCCC/ACGAGG`	2	--	int¹		8		MN EU EA WA NA	722
	rs6688441^1,2	A,C,F,H	233555807(+)	`TACAAC/ACACAA`	2	--	int¹		8		EU EA WA	836
	rs12409696^1,2	A,C,F,H	233490230(+)	`GAATTT/CGGCAT`	2	--	int¹		4		EU EA WA	414
	rs7339903^1,2	A,C,F,H	233404356(+)	`tcaaaC/Tcggga`	2	--	int¹		4		EU EA WA	418
	rs11587367^1,2	A,C,F,H	233552308(+)	`CCCTTT/CTATTC`	2	--	int¹		11		EU EA WA NA	956

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HapMap Linkage Disequilibrium images for ARID4B (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 609696

2 Novoseek disease relationships for ARID4B gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	46.11	4	10777059 (1), 16479010 (1), 1646903 (1)
tumors	0.00	1	8946837 (1)

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(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/21 PubMed articles for ARID4B gene (see all 21 ):

RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis. (PubMed id 11481388)^{2, 3, 4} Cao J.-N.... Irie R. (2001)
Characterization of BRCAA1 and its novel antigen epitope identification. (PubMed id 15247124)^{1, 3, 4} Cui D....Sarai A. (2004)
Identification and characterization of three new components of the mSin3A corepressor complex. (PubMed id 12724404)^{1, 3, 4} Fleischer T.C....Ayer D.E. (2003)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)⁴ Daub H.... Mann M. (2008)
Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)⁴ Imami K.... Ishihama Y. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 51742	HGNC: 15550	AceView: ARID4B	Ensembl:ENSG00000054267	euGenes: HUgn51742
ECgene: ARID4B	H-InvDB: ARID4B

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for ARID4B	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ARID4B
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for ARID4B:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ARID4B-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ARID4B		Antibodies for ARID4B
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ARID4B		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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ARID4B Gene at Home site.
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ARID4B Gene

protein-coding GIFtS: 57

Aliases &
Descriptions
for ARID4B

Summaries
for ARID4B

Genomic Location
for ARID4B

Proteins
for ARID4B

Protein Domains/
Families
for ARID4B

Gene Function
for ARID4B

Pathways & Interactions
for ARID4B

Drugs & Compounds
for ARID4B

Transcripts
for ARID4B

Expression
for ARID4B

Orthologs
for ARID4B

Paralogs
for ARID4B

SNPs/Variants
for ARID4B

Disorders & Mutations
for ARID4B

Medical News
for ARID4B

Publications
for ARID4B

Search for ARID4B

Genome Databases showing ARID4B

Other Databases showing ARID4B

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for ARID4B

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for ARID4B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ARID4B (Gene Symbol)
BCAA
BRCAA1
DKFZp313M2420
MGC163290
OTTHUMP00000037596
RBBP1L1
RBP1L1
SAP180
180 kDa Sin3-associated polypeptide
ARID domain-containing protein 4B
AT rich interactive domain 4B
AT rich interactive domain 4B (RBP1- like)
AT rich interactive domain 4B (RBP1-like)
Breast cancer-associated antigen BRCAA1
Histone deacetylase complex subunit SAP180
RBP1-like protein
Rb-binding protein homolog
Retinoblastoma-binding protein 1-like 1
SIN3A-associated protein 180
Sin3-associated polypeptide p180
breast cancer-associated antigen 1
breast carcinoma-associated antigen
retinoblastoma binding protein 1-like 1

ARID4B Gene

protein-coding GIFtS: 57

Aliases & Descriptionsfor ARID4B

Summariesfor ARID4B

Genomic Locationfor ARID4B

Proteinsfor ARID4B

Protein Domains/Familiesfor ARID4B

Gene Functionfor ARID4B

Pathways & Interactionsfor ARID4B

Drugs & Compoundsfor ARID4B

Transcriptsfor ARID4B

Expression for ARID4B

Orthologsfor ARID4B

Paralogsfor ARID4B

SNPs/Variantsfor ARID4B

Disorders & Mutationsfor ARID4B

Medical Newsfor ARID4B

Publicationsfor ARID4B

Search for ARID4B

Genome Databases showing ARID4B

Other Databases showing ARID4B

Specialized Databases showing ARID4B

Licensable Technologiesfor ARID4B

Servicesfor ARID4B

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ARID4B

Summaries
for ARID4B

Genomic Location
for ARID4B

Proteins
for ARID4B

Protein Domains/
Families
for ARID4B

Gene Function
for ARID4B

Pathways & Interactions
for ARID4B

Drugs & Compounds
for ARID4B

Transcripts
for ARID4B

Expression
for ARID4B

Orthologs
for ARID4B

Paralogs
for ARID4B

SNPs/Variants
for ARID4B

Disorders & Mutations
for ARID4B

Medical News
for ARID4B

Publications
for ARID4B

Licensable Technologies
for ARID4B

Services
for ARID4B