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ARID4B Gene

protein-coding   GIFtS: 59
GCID: GC01M235298

AT Rich Interactive Domain 4B (RBP1-Like)

(Previous names: retinoblastoma binding protein 1-like 1, AT rich interactive...)
(Previous symbol: RBP1L1)
  See ARID4B-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
AT Rich Interactive Domain 4B (RBP1-Like)1 2     ARID Domain-Containing Protein 4B2 3
RBP1L11 2 3 5     AT Rich Interactive Domain 4B (RBP1- Like)1
BRCAA12 3 5     Retinoblastoma Binding Protein 1-Like 11
RBBP1L12 3 5     BCAA2
SAP1802 3 5     AT-Rich Interactive Domain-Containing Protein 4B2
Breast Cancer-Associated Antigen BRCAA12 3     Breast Cancer-Associated Antigen 12
Histone Deacetylase Complex Subunit SAP1802 3     Breast Carcinoma-Associated Antigen2
Retinoblastoma-Binding Protein 1-Like 12 3     Rb-Binding Protein Homolog2
Sin3-Associated Polypeptide P1802 3     SIN3A-Associated Protein 1802
180 KDa Sin3-Associated Polypeptide2 3     

External Ids:    HGNC: 155501   Entrez Gene: 517422   Ensembl: ENSG000000542677   OMIM: 6096965   UniProtKB: Q4LE393   

Export aliases for ARID4B gene to outside databases

Previous GC identifers: GC01M232336 GC01M232371 GC01M231621 GC01M233396 GC01M235295 GC01M205778 GC01M235296


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARID4B Gene:
This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a
subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in
diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate
determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears
to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice
variants encoding different isoforms have been characterized. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARID4B Gene:
ARID4B (AT rich interactive domain 4B (RBP1-like)) is a protein-coding gene. Diseases associated with ARID4B include retinoblastoma, and breast cancer. An important paralog of this gene is ARID5A.

UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39
Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A
corepressor complex or in mediating interactions between the complex and other regulatory complexes

Gene Wiki entry for ARID4B Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_167186.2  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARID4B gene promoter:
         HOXA9B   HOXA9   CUTL1   LCR-F1   YY1   FOXO4   Sox9   IRF-7A   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARID4B promoter sequence
   Search Chromatin IP Primers for ARID4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARID4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q42.1-q43   Ensembl cytogenetic band:  1q42.3   HGNC cytogenetic band: 1q42.1-q43

ARID4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARID4B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M235298:  view genomic region     (about GC identifiers)

Start:
235,294,949 bp from pter      End:
235,491,534 bp from pter
Size:
196,586 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39 (See protein sequence)
Recommended Name: AT-rich interactive domain-containing protein 4B  
Size: 1312 amino acids; 147809 Da
Subunit: Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and
HDAC2
Sequence caution: Sequence=AAD41239.1; Type=Frameshift; Positions=859, 869, 1287, 1311; Sequence=AAF23433.3;
Type=Frameshift; Positions=1287, 1311; Sequence=BAB14428.1; Type=Erroneous initiation; Sequence=BAE06114.1;
Type=Erroneous initiation; Sequence=CAI13751.1; Type=Erroneous gene model prediction;
Secondary accessions: A1L465 Q3MHV4 Q5HY99 Q5T2C2 Q5T2C3 Q5T2C4 Q5T2C5 Q5T2C6 Q6P600 Q86UX1
Q86WR4 Q9H915 Q9NYU3 Q9NZB6 Q9NZG4 Q9P2W4 Q9UF62 Q9Y6E1
Alternative splicing: 4 isoforms:  Q4LE39-1   Q4LE39-2   Q4LE39-3   Q4LE39-4   

Explore the universe of human proteins at neXtProt for ARID4B: NX_Q4LE39

Explore proteomics data for ARID4B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARID4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001193723.1  NP_057458.4  NP_112739.2  

    ENSEMBL proteins: 
     ENSP00000420620   ENSP00000264184   ENSP00000355562   ENSP00000394663   ENSP00000416063  
     ENSP00000391497   ENSP00000264183  
    Reactome Protein details: Q4LE39

    ARID4B Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ARID4B

     
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    ARID4B Antibody Products:

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    ARID4B Assay Products:

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    Cloud-Clone Corp. ELISAs for ARID4B
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    Search eBioscience for ELISAs for ARID4B 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 7):
     IPR000953 Chromo_domain/shadow
     IPR028853 ARID4B
     IPR016197 Chromodomain-like
     IPR025995 Tudor-knot
     IPR002999 Tudor

    Graphical View of Domain Structure for InterPro Entry Q4LE39

    ProtoNet protein and cluster: Q4LE39

    4 Blocks protein domains:
    IPB000953 Chromo domain
    IPB001606 ARID (AT-rich interaction domain) protein
    IPB002999 Tudor domain
    IPB012603 RBB1NT


    UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39
    Domain: The C-terminus mediates interaction with mSin3A corepressor complex
    Domain: The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms
    Domain: The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA
    Similarity: Contains 1 ARID domain


    Find genes that share domains with ARID4B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARI4B_HUMAN, Q4LE39
    Function: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A
    corepressor complex or in mediating interactions between the complex and other regulatory complexes

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0003677DNA binding IEA--
    GO:0005515protein binding IPI--
         
    Find genes that share ontologies with ARID4B           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARID4B:
     Decreased POU5F1-GFP protein e  Increased G1 DNA content 

         12 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arid4b):
     cardiovascular system  cellular  growth/size/body  hematopoietic system  immune system 
     liver/biliary system  mortality/aging  renal/urinary system  reproductive system  respiratory system 
     skeleton  tumorigenesis 

    Find genes that share phenotypes with ARID4B           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arid4btm1Alb for ARID4B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARID4B
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARID4B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARID4B

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARID4B:
    hsa-mir-93-5p (MIRT028050), hsa-mir-92a-3p (MIRT004089), hsa-mir-20b-5p (MIRT004072), hsa-mir-106a-5p (MIRT004028), hsa-mir-19b-3p (MIRT004065), hsa-mir-17-3p (MIRT050768), hsa-mir-130b-3p (MIRT020213)

    Block miRNA regulation of human, mouse, rat ARID4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARID4B (see all 114):
    hsa-miR-3194-5p hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-199a-3p hsa-miR-106a hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidARID4B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARID4B
    Predesigned siRNA for gene silencing in human, mouse, rat ARID4B

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for ARID4B (see all 13)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ARID4B (NM_001206794)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARID4B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARID4B

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for ARID4B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARID4B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARI4B_HUMAN, Q4LE39: Nucleus (By similarity). Cytoplasm. Note=Cytoplasmic in breast cancer cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with ARID4B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARID4B About    
    See pathways by source

    SuperPathContained pathways About
    1Development NOTCH1 mediated pathway for NF KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35


    Find genes that share SuperPaths with ARID4B           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ARID4B
        Transcription Sin3 and NuRD in transcription regulation

    1 Reactome Pathway for ARID4B
        NoRC negatively regulates rRNA expression


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARID4B
    Interactions:

        Search GeneGlobe Interaction Network for ARID4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARID4B (Q4LE391, 3 ENSP000002641834) via UniProtKB, MINT, STRING, and/or I2D (see all 81)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ETS1P149211, 3EBI-2680990,EBI-913209 I2D: score=1 
    RANBP2P497923, ENSP000002831954I2D: score=3 STRING: ENSP00000283195
    ARID4AP293743, ENSP000003476024I2D: score=1 STRING: ENSP00000347602
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    SIRT1Q96EB63, ENSP000002120154I2D: score=1 STRING: ENSP00000212015
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006349regulation of gene expression by genetic imprinting IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0008150biological_process ND--
    GO:0034773histone H4-K20 trimethylation IEA--

    Find genes that share ontologies with ARID4B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARID4B (ARI4B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARID4B gene (3 alternative transcripts): 
    NM_001206794.1  NM_016374.5  NM_031371.3  

    Unigene Cluster for ARID4B:

    AT rich interactive domain 4B (RBP1-like)
    Hs.575782  [show with all ESTs]
    Unigene Representative Sequence: NM_016374
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000474953(uc001hwp.3) ENST00000349213(uc001hwr.3) ENST00000366603(uc021pks.1)
    ENST00000421364 ENST00000474401 ENST00000491632(uc001hws.4) ENST00000444620
    ENST00000494543 ENST00000471257(uc001hwt.4) ENST00000418304 ENST00000466653(uc001hwu.1)
    ENST00000462969 ENST00000264183(uc001hwq.3)
    miRNA
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    Block miRNA regulation of human, mouse, rat ARID4B using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARID4B (see all 114):
    hsa-miR-3194-5p hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-199a-3p hsa-miR-106a hsa-miR-374a
    SwitchGear 3'UTR luciferase reporter plasmidARID4B 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARID4B
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): ARID4B (NM_001206794)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARID4B
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for ARID4B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARID4B
      QuantiTect SYBR Green Assays in human, mouse, rat ARID4B
      QuantiFast Probe-based Assays in human, mouse, rat ARID4B

    Additional mRNA sequence: 

    AB210032.1 AF083249.1 AF208045.2 AF214114.2 AF227899.1 AK023144.1 AL133594.1 AY220790.1 
    BC017800.1 BC048959.1 BC062536.1 BC104632.1 BC130418.1 BC143719.1 BX648820.1 

    19 DOTS entries:

    DT.97807555  DT.100791932  DT.95174930  DT.95369910  DT.95174928  DT.101983160  DT.444260  DT.100791933 
    DT.95174931  DT.97786083  DT.315604  DT.92016831  DT.100665761  DT.121438798  DT.40125838  DT.91743274 
    DT.95174935  DT.95237769  DT.95369908 

    Selected AceView cDNA sequences (see all 393):

    AA810515 BM675648 AI473662 BX508089 AI091806 BQ929526 T28187 BX501164 
    AW327787 AI184478 AI860543 CA306263 BU608657 AU131136 AW590370 AK023144 
    AA907555 AA399016 AI263057 BQ640519 AU139233 AA249163 AI632699 F33250 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARID4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTCTTTGT
    ARID4B Expression
    About this image


    ARID4B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Ovary (Reproductive System)
             Oviduct
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebellum
    ARID4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARID4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.575782

    UniProtKB/Swiss-Prot: ARI4B_HUMAN, Q4LE39
    Tissue specificity: Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers.
    Expressed at low levels in the thymus, prostate and ovary

        Custom PCR Arrays for ARID4B
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    QuantiFast Probe-based Assays in human, mouse, rat ARID4B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARID4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARID4B gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arid4b1 , 5 AT rich interactive domain 4B (RBP1-like)1, 5 88.27(n)1
    88.73(a)1
      13 (5.29 cM)5
    942461  NM_194262.21  NP_919238.11 
     140632325 
    chicken
    (Gallus gallus)
    Aves ARID4B1 AT rich interactive domain 4B (RBP1-like) 79.16(n)
    80.56(a)
      425840  XM_003640986.2  XP_003641034.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARID4B6
    AT rich interactive domain 4B (RBP1-like)
    77(a)
    1 ↔ 1
    1(219569474-219629761)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL898445.12   -- 78.52(n)    AL898445.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005379231 AT-rich interactive domain-containing protein 4B-like 59.47(n)
    59.05(a)
      100537923  XM_003199758.2  XP_003199806.2 
    worm
    (Caenorhabditis elegans)
    Secernentea arid-16
    Protein ARID-1 (arid-1) mRNA, complete cds
    16(a)
    1 → many
    V(186305-200686) WBGene00044689


    ENSEMBL Gene Tree for ARID4B (if available)
    TreeFam Gene Tree for ARID4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARID4B gene
    ARID5A2  ARID4A2  ARID5B2  
    1 SIMAP similar gene for ARID4B using alignment to 4 protein entries:     ARI4B_HUMAN (see all proteins):
    ARID4A

    Find genes that share paralogs with ARID4B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARID4B (see all 3280)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1118707641,2
    C,F--235335145(+) AGAGAC/TGGGGT 3 -- int11Minor allele frequency- T:0.50CSA 2
    rs723049481,2
    C--235356396(+) AGCGA-/AGACTC 3 -- int10--------
    rs1138659221,2
    C,F--235356541(+) ACCCCG/ATCTCT 3 -- int11Minor allele frequency- A:0.50NA 2
    rs711722681,2
    C--235360169(+) AAAAAA/-AAAAA 3 -- int11Minor allele frequency- -:0.00NA 2
    rs1134581771,2
    C--235377279(+) CTTCC-/TCCTCCTC 3 -- cds1 int11Minor allele frequency- TCC:0.50CSA 2
    rs105888171,2
    C--235377281(+) tcctc-/CTCttctg 3 -- cds1 int10--------
    rs2012220041,2
    C--235378085(-) CATCTA/GTNNNN 3 -- int10--------
    rs676437311,2
    C--235378153(+) ATCCTTTTT/-  
            
    TTTTT
    3 -- int11Minor allele frequency- -:0.00NA 2
    rs671298311,2
    C--235382180(+) TTTTTTT/-TTTTT 3 -- int11Minor allele frequency- -:0.00NA 2
    rs114058771,2
    C--235384720(+) TAGTAT/-TCATA 3 -- int12Minor allele frequency- -:0.00NA CSA 4

    HapMap Linkage Disequilibrium report for ARID4B (235294949 - 235491534 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for ARID4B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2725318CNV Deletion23290073
    esv1108970CNV Deletion17803354
    esv2725307CNV Deletion23290073
    esv1314619CNV Insertion17803354
    esv1721702CNV Insertion17803354
    dgv548n71CNV Loss21882294
    nsv827453CNV Loss20364138
    nsv873321CNV Gain21882294
    dgv30n21CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARID4B
    DNA2.0 Custom Variant and Variant Library Synthesis for ARID4B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609696    OMIM disorders: --

    2 diseases for ARID4B:    
    About MalaCards
    retinoblastoma    breast cancer


    Find genes that share disorders with ARID4B           About GenesLikeMe

    2 Novoseek inferred disease relationships for ARID4B gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 45 4 10777059 (1), 16479010 (1), 1646903 (1)
    tumors 0 1 8946837 (1)

    Genetic Association Database (GAD): ARID4B
    Human Genome Epidemiology (HuGE) Navigator: ARID4B (2 documents)

    Export disorders for ARID4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARID4B gene, integrated from 10 sources (see all 36):
    (articles sorted by number of sources associating them with ARID4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis. (PubMed id 11481388)1, 2, 3 Cao J.-N.... Irie R. (J. Natl. Cancer Inst. 2001)
    2. Characterization of BRCAA1 and its novel antigen epitope identification. (PubMed id 15247124)1, 2, 9 Cui D....Sarai A. (Cancer Epidemiol. Biomarkers Prev. 2004)
    3. Identification and characterization of three new components of the mSin3A corepressor complex. (PubMed id 12724404)1, 2, 9 Fleischer T.C.... Ayer D.E. (Mol. Cell. Biol. 2003)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PubMed id 20347265)1, 4 Xu Y....Liu P. (Schizophr. Res. 2010)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    7. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The functional interactome landscape of the human histone deacetylase family. (PubMed id 23752268)1 Joshi P....Cristea I.M. (Mol. Syst. Biol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 51742 HGNC: 15550 AceView: ARID4B Ensembl:ENSG00000054267 euGenes: HUgn51742
    ECgene: ARID4B H-InvDB: ARID4B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARID4B Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARID4B Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARID4B gene:
    Search GeneIP for patents involving ARID4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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