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Aliases for ARID4B Gene

Aliases for ARID4B Gene

  • AT-Rich Interaction Domain 4B 2 3 5
  • Histone Deacetylase Complex Subunit SAP180 3 4
  • AT Rich Interactive Domain 4B (RBP1-Like) 2 3
  • Breast Cancer-Associated Antigen BRCAA1 3 4
  • Retinoblastoma-Binding Protein 1-Like 1 3 4
  • 180 KDa Sin3-Associated Polypeptide 3 4
  • ARID Domain-Containing Protein 4B 3 4
  • Sin3-Associated Polypeptide P180 3 4
  • RBBP1L1 3 4
  • RBP1L1 3 4
  • BRCAA1 3 4
  • SAP180 3 4
  • AT-Rich Interactive Domain-Containing Protein 4B 3
  • AT Rich Interactive Domain 4B (RBP1- Like) 2
  • Retinoblastoma Binding Protein 1-Like 1 2
  • Breast Carcinoma-Associated Antigen 3
  • Breast Cancer-Associated Antigen 1 3
  • SIN3A-Associated Protein 180 3
  • Rb-Binding Protein Homolog 3
  • BCAA 3

External Ids for ARID4B Gene

Previous HGNC Symbols for ARID4B Gene

  • RBP1L1

Previous GeneCards Identifiers for ARID4B Gene

  • GC01M232336
  • GC01M232371
  • GC01M231621
  • GC01M233396
  • GC01M235295
  • GC01M205778
  • GC01M235296
  • GC01M235298

Summaries for ARID4B Gene

Entrez Gene Summary for ARID4B Gene

  • This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID4B Gene

ARID4B (AT-Rich Interaction Domain 4B) is a Protein Coding gene. Diseases associated with ARID4B include Breast Cancer. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include transcription regulatory region DNA binding. An important paralog of this gene is ARID4A.

UniProtKB/Swiss-Prot for ARID4B Gene

  • Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Gene Wiki entry for ARID4B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID4B Gene

Genomics for ARID4B Gene

Regulatory Elements for ARID4B Gene

Enhancers for ARID4B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F235289 1.4 FANTOM5 Ensembl ENCODE 29.7 +32.5 32498 12.8 PKNOX1 ATF1 MLX ZFP64 ARID4B SIN3A ZNF121 GATA2 FOS ZNF202 ARID4B RPS21P1 GGPS1 LDHAP2 TOMM20 RBM34 RPL23AP23 GC01P235225
GH01F235304 1.6 FANTOM5 Ensembl ENCODE 28.8 +23.0 22998 3.4 CTCF PKNOX1 FEZF1 ZNF121 ZNF316 GATA3 PRDM10 NR2F6 ZNF600 TCF7L2 ARID4B GGPS1 RBM34 GC01M235309 RPL23AP23
GH01F235266 0.5 Ensembl 22.5 +61.8 61798 0.2 ZNF121 ZNF664 ZNF316 RFX1 RFX3 BMI1 ARID4B GGPS1 RPL23AP23 GC01P235225
GH01F235278 0.7 Ensembl 22.4 +48.9 48898 1.6 HDGF YBX3 NFRKB FOS EGR2 SMARCA5 ZBTB11 MEF2D MAFF SMARCA4 GGPS1 ARID4B RPL23AP23 GC01P235225
GH01F235280 0.2 Ensembl 22.4 +47.7 47698 0.4 HIC1 ZNF202 ZBTB33 ARID4B RPS21P1 GGPS1 RPL23AP23 GC01P235225
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARID4B on UCSC Golden Path with GeneCards custom track

Promoters for ARID4B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001592091 198 6201 CREB3L1 ZFP64 FEZF1 YY1 ZNF416 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for ARID4B Gene

Chromosome:
1
Start:
235,131,634 bp from pter
End:
235,328,298 bp from pter
Size:
196,665 bases
Orientation:
Minus strand

Genomic View for ARID4B Gene

Genes around ARID4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARID4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARID4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID4B Gene

Proteins for ARID4B Gene

  • Protein details for ARID4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4LE39-ARI4B_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 4B
    Protein Accession:
    Q4LE39
    Secondary Accessions:
    • A1L465
    • Q3MHV4
    • Q5HY99
    • Q5T2C2
    • Q5T2C3
    • Q5T2C4
    • Q5T2C5
    • Q5T2C6
    • Q6P600
    • Q86UX1
    • Q86WR4
    • Q9H915
    • Q9NYU3
    • Q9NZB6
    • Q9NZG4
    • Q9P2W4
    • Q9UF62
    • Q9Y6E1

    Protein attributes for ARID4B Gene

    Size:
    1312 amino acids
    Molecular mass:
    147809 Da
    Quaternary structure:
    • Component of a Sin3A corepressor complex consisting of SIN3A, SAP130, SUDS3/SAP45, SAP180, HDAC1 and HDAC2.
    SequenceCaution:
    • Sequence=AAD41239.1; Type=Frameshift; Positions=859, 869, 1287, 1311; Evidence={ECO:0000305}; Sequence=AAF23433.3; Type=Frameshift; Positions=1287, 1311; Evidence={ECO:0000305}; Sequence=BAB14428.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAE06114.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI13751.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for ARID4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARID4B Gene

Post-translational modifications for ARID4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for ARID4B
  • Santa Cruz Biotechnology (SCBT) Antibodies for ARID4B

No data available for DME Specific Peptides for ARID4B Gene

Domains & Families for ARID4B Gene

Gene Families for ARID4B Gene

Suggested Antigen Peptide Sequences for ARID4B Gene

Graphical View of Domain Structure for InterPro Entry

Q4LE39

UniProtKB/Swiss-Prot:

ARI4B_HUMAN :
  • The C-terminus mediates interaction with mSin3A corepressor complex.
Domain:
  • The C-terminus mediates interaction with mSin3A corepressor complex.
  • The N-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
  • The ARID domain is involved in stabilizing the mSin3A corepressor complex on DNA.
  • Contains 1 ARID domain.
genes like me logo Genes that share domains with ARID4B: view

Function for ARID4B Gene

Molecular function for ARID4B Gene

UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.

Gene Ontology (GO) - Molecular Function for ARID4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003677 DNA binding IEA --
GO:0004407 histone deacetylase activity TAS --
GO:0005515 protein binding IPI 20195357
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ARID4B: view
genes like me logo Genes that share phenotypes with ARID4B: view

Animal Models for ARID4B Gene

MGI Knock Outs for ARID4B:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARID4B Gene

Localization for ARID4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID4B Gene

Nucleus. Cytoplasm. Note=Cytoplasmic in breast cancer cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID4B Gene COMPARTMENTS Subcellular localization image for ARID4B gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for ARID4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARID4B: view

Pathways & Interactions for ARID4B Gene

genes like me logo Genes that share pathways with ARID4B: view

Pathways by source for ARID4B Gene

Gene Ontology (GO) - Biological Process for ARID4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006349 regulation of gene expression by genetic imprinting IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with ARID4B: view

No data available for SIGNOR curated interactions for ARID4B Gene

Transcripts for ARID4B Gene

Unigene Clusters for ARID4B Gene

AT rich interactive domain 4B (RBP1-like):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARID4B Gene

No ASD Table

Relevant External Links for ARID4B Gene

GeneLoc Exon Structure for
ARID4B
ECgene alternative splicing isoforms for
ARID4B

Expression for ARID4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARID4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARID4B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (13.0), Gallbladder (11.1), CD8 Tcells (10.3), and Cerebrospinal fluid (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARID4B Gene



Protein tissue co-expression partners for ARID4B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARID4B Gene:

ARID4B

SOURCE GeneReport for Unigene cluster for ARID4B Gene:

Hs.575782

mRNA Expression by UniProt/SwissProt for ARID4B Gene:

Q4LE39-ARI4B_HUMAN
Tissue specificity: Highly expressed in the testis and in breast, lung, colon, pancreatic and ovarian cancers. Expressed at low levels in the thymus, prostate and ovary.
genes like me logo Genes that share expression patterns with ARID4B: view

Primer Products

No data available for mRNA differential expression in normal tissues for ARID4B Gene

Orthologs for ARID4B Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID4B 34 35
  • 99.67 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 96 (a)
OneToMany
-- 35
  • 70 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ARID4B 34 35
  • 93.69 (n)
cow
(Bos Taurus)
Mammalia ARID4B 34 35
  • 90.54 (n)
mouse
(Mus musculus)
Mammalia Arid4b 34 16 35
  • 88.27 (n)
oppossum
(Monodelphis domestica)
Mammalia ARID4B 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100912163 34
  • 86.15 (n)
chicken
(Gallus gallus)
Aves ARID4B 34 35
  • 79.16 (n)
lizard
(Anolis carolinensis)
Reptilia ARID4B 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arid4b 34
  • 68.25 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100537923 34
  • 59.47 (n)
tomm20a 35
  • 54 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea arid-1 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 45 (a)
OneToMany
Species where no ortholog for ARID4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARID4B Gene

ENSEMBL:
Gene Tree for ARID4B (if available)
TreeFam:
Gene Tree for ARID4B (if available)

Paralogs for ARID4B Gene

Paralogs for ARID4B Gene

(1) SIMAP similar genes for ARID4B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with ARID4B: view

Variants for ARID4B Gene

Sequence variations from dbSNP and Humsavar for ARID4B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10157739 -- 235,191,240(+) TGTCA(C/G)ATATT intron-variant, upstream-variant-2KB
rs10158444 -- 235,292,956(+) TCAAA(C/T)GAATA intron-variant
rs10218588 -- 235,255,222(+) AGCTA(G/T)ATAGA intron-variant
rs10218590 -- 235,255,388(+) TTGGG(A/G)AAAAA intron-variant
rs10218722 -- 235,255,076(+) CCTAA(C/T)TAAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID4B Gene

Variant ID Type Subtype PubMed ID
dgv30n21 CNV gain 19592680
esv1108970 CNV deletion 17803354
esv1314619 CNV insertion 17803354
esv1721702 CNV insertion 17803354
esv2725307 CNV deletion 23290073
esv2725318 CNV deletion 23290073
nsv1013571 CNV gain 25217958
nsv1068631 CNV deletion 25765185
nsv1130637 CNV deletion 24896259
nsv1148731 CNV insertion 26484159
nsv549391 CNV loss 21841781
nsv827453 CNV loss 20364138
nsv947473 CNV duplication 23825009
nsv956652 CNV deletion 24416366

Variation tolerance for ARID4B Gene

Residual Variation Intolerance Score: 3.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.32; 63.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARID4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARID4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID4B Gene

Disorders for ARID4B Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARID4B Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARID4B

Genetic Association Database (GAD)
ARID4B
Human Genome Epidemiology (HuGE) Navigator
ARID4B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARID4B
genes like me logo Genes that share disorders with ARID4B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARID4B Gene

Publications for ARID4B Gene

  1. Characterization of BRCAA1 and its novel antigen epitope identification. (PMID: 15247124) Cui D. … Sarai A. (Cancer Epidemiol. Biomarkers Prev. 2004) 3 4 22 64
  2. Identification and characterization of three new components of the mSin3A corepressor complex. (PMID: 12724404) Fleischer T.C. … Ayer D.E. (Mol. Cell. Biol. 2003) 3 4 22 64
  3. RBP1L1, a retinoblastoma-binding protein-related gene encoding an antigenic epitope abundantly expressed in human carcinomas and normal testis. (PMID: 11481388) Cao J.-N. … Irie R. (J. Natl. Cancer Inst. 2001) 2 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. MicroRNAs and target site screening reveals a pre-microRNA-30e variant associated with schizophrenia. (PMID: 20347265) Xu Y. … Liu P. (Schizophr. Res. 2010) 3 46 64

Products for ARID4B Gene

Sources for ARID4B Gene

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