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ARID4A Gene

protein-coding   GIFtS: 56
GCID: GC14P058766

AT Rich Interactive Domain 4A (RBP1-Like)

(Previous name: retinoblastoma-binding protein 1)
(Previous symbol: RBBP1)
  See ARID4A-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
AT Rich Interactive Domain 4A (RBP1-Like)1 2     ARID Domain-Containing Protein 4A2 3
RBBP11 2 3 5     RBP-12
Retinoblastoma-Binding Protein 11 2 3     AT-Rich Interactive Domain-Containing Protein 4A2
RBP12 3 5     Retinoblastoma Binding Protein 12
RBBP-12 3     

External Ids:    HGNC: 98851   Entrez Gene: 59262   Ensembl: ENSG000000322197   OMIM: 1802015   UniProtKB: P293743   

Export aliases for ARID4A gene to outside databases

Previous GC identifers: GC14P056756 GC14P056757 GC14P057835 GC14P038930


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARID4A Gene:
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several
other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription
by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in
addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional
repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not
all transcript variants have been fully described. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARID4A Gene:
ARID4A (AT rich interactive domain 4A (RBP1-like)) is a protein-coding gene. Diseases associated with ARID4A include retinoblastoma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ARID4B.

UniProtKB/Swiss-Prot: ARI4A_HUMAN, P29374
Function: Interacts with the viral protein-binding domain of the retinoblastoma protein

Gene Wiki entry for ARID4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARID4A gene promoter:
         USF1   Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARID4A promoter sequence
   Search Chromatin IP Primers for ARID4A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARID4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q22.3

ARID4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARID4A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P058766:  view genomic region     (about GC identifiers)

Start:
58,765,103 bp from pter      End:
58,840,605 bp from pter
Size:
75,503 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARI4A_HUMAN, P29374 (See protein sequence)
Recommended Name: AT-rich interactive domain-containing protein 4A  
Size: 1257 amino acids; 142752 Da
Subunit: Interacts with BRMS1. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4,
RBBP7, SAP30, BRMS1, HDAC1 and HDAC2
3 PDB 3D structures from and Proteopedia for ARID4A:
2LCC (3D)        2MAM (3D)        2YRV (3D)    
Secondary accessions: Q15991 Q15992 Q15993
Alternative splicing: 3 isoforms:  P29374-1   P29374-2   P29374-3   

Explore the universe of human proteins at neXtProt for ARID4A: NX_P29374

Explore proteomics data for ARID4A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARID4A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_002883.3  NP_075376.2  NP_075377.2  

    ENSEMBL proteins: 
     ENSP00000347602   ENSP00000378597   ENSP00000410417   ENSP00000392567   ENSP00000415872  
     ENSP00000397368   ENSP00000416053   ENSP00000344556  

    ARID4A Human Recombinant Protein Products:

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    Novus Biologicals ARID4A Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARID4A

     
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    antibodies-online proteins for ARID4A (2 products) 

     
    antibodies-online peptides for ARID4A

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    antibodies-online antibodies for ARID4A (11 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 6):
     IPR000953 Chromo_domain/shadow
     IPR016197 Chromodomain-like
     IPR025995 Tudor-knot
     IPR002999 Tudor
     IPR001606 ARID/BRIGHT_DNA-bd

    Graphical View of Domain Structure for InterPro Entry P29374

    ProtoNet protein and cluster: P29374

    4 Blocks protein domains:
    IPB000953 Chromo domain
    IPB001606 ARID (AT-rich interaction domain) protein
    IPB002999 Tudor domain
    IPB012603 RBB1NT


    UniProtKB/Swiss-Prot: ARI4A_HUMAN, P29374
    Similarity: Contains 1 ARID domain


    Find genes that share domains with ARID4A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARI4A_HUMAN, P29374
    Function: Interacts with the viral protein-binding domain of the retinoblastoma protein

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8414517
         
    Find genes that share ontologies with ARID4A           About GenesLikeMe


    Phenotypes:
         Selected MGI mutant phenotypes (inferred from 2 alleles(MGI details for Arid4a) (see all 16):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size/body 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  renal/urinary system  reproductive system  respiratory system  skeleton 

    Find genes that share phenotypes with ARID4A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arid4atm1Alb for ARID4A

       genOway: Develop your customized and physiologically relevant rodent model for ARID4A

    miRNA
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    miRTarBase miRNAs that target ARID4A:
    hsa-mir-335-5p (MIRT018511), hsa-mir-21-5p (MIRT030996)

    Block miRNA regulation of human, mouse, rat ARID4A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARID4A (see all 85):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-519a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidARID4A 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for ARID4A
    Predesigned siRNA for gene silencing in human, mouse, rat ARID4A

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): ARID4A (NM_002892)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARID4A
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    Addgene plasmids for ARID4A 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARI4A_HUMAN, P29374: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS8414517
    GO:0017053transcriptional repressor complex IDA11283269

    Find genes that share ontologies with ARID4A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARID4A About    
    See pathways by source

    SuperPathContained pathways About
    1Development NOTCH1 mediated pathway for NF KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for ARID4A
        Visual Cycle in Retinal Rods

    1 GeneGo (Thomson Reuters) Pathway for ARID4A
        Transcription Sin3 and NuRD in transcription regulation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARID4A
    Interactions:

        GeneGlobe Interaction Network for ARID4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARID4A (P293743 ENSP000003476024) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNA2P202483, ENSP000002740264I2D: score=1 STRING: ENSP00000274026
    CDK2P249413, ENSP000002669704I2D: score=1 STRING: ENSP00000266970
    RBBP4Q090283, ENSP000003625924I2D: score=1 STRING: ENSP00000362592
    SAP30O754463, ENSP000002965044I2D: score=1 STRING: ENSP00000296504
    SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006349regulation of gene expression by genetic imprinting IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS8414517
    GO:0034773histone H4-K20 trimethylation IEA--
    GO:0036124histone H3-K9 trimethylation IEA--
    GO:0045892negative regulation of transcription, DNA-templated IDA12724404

    Find genes that share ontologies with ARID4A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARID4A (ARI4A)

    1 Novoseek inferred chemical compound relationship for ARID4A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 2.97 4 16873370 (2), 15802376 (1)



    Find genes that share compounds with ARID4A           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARID4A gene (3 alternative transcripts): 
    NM_002892.3  NM_023000.2  NM_023001.2  

    Unigene Cluster for ARID4A:

    AT rich interactive domain 4A (RBP1-like)
    Hs.161000  [show with all ESTs]
    Unigene Representative Sequence: NM_002892
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355431(uc001xdo.3 uc001xdp.3 uc001xdq.3) ENST00000395168
    ENST00000431612(uc010apf.1) ENST00000445108 ENST00000424658 ENST00000431317
    ENST00000417477(uc010apg.1) ENST00000553355 ENST00000469635 ENST00000466065
    ENST00000348476
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARID4A (see all 85):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-519a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidARID4A 3' UTR sequence
    Inhib. RNA
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    Addgene plasmids for ARID4A 
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      QuantiTect SYBR Green Assays in human, mouse, rat ARID4A
      QuantiFast Probe-based Assays in human, mouse, rat ARID4A

    Additional mRNA sequence: 

    AF086075.1 AK307520.1 AK307972.1 BC026230.1 S57153.1 S57160.1 S57162.1 S66427.1 

    13 DOTS entries:

    DT.305572  DT.70100576  DT.95166579  DT.92426621  DT.100766938  DT.427233  DT.92426622  DT.91892297 
    DT.95153366  DT.86849476  DT.92426623  DT.95152704  DT.95166581 

    Selected AceView cDNA sequences (see all 101):

    AW949879 AF086075 BX504085 BE618019 CB156934 BQ922162 BQ439648 H88595 
    AI436281 AL700599 BX510119 BG941641 N48365 AW162962 AI246187 BG942986 
    BC026230 CA945122 BE882846 AL699636 AV660033 AW473272 C01408 AI809603 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARID4A (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
    SP1:              -                                                                                                                                             
    SP2:              -                 -                                                                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for ARID4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARID4A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARID4A Expression
    About this image


    ARID4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Granulocytes Peripheral Blood
    ARID4A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARID4A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.161000
        Custom PCR Arrays for ARID4A
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARID4A
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    QuantiFast Probe-based Assays in human, mouse, rat ARID4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARID4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARID4A gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arid4a1 , 5 AT rich interactive domain 4A (RBP1-like)1, 5 84.99(n)1
    85.98(a)1
      12 (29.39 cM)5
    2382471  NM_001081195.11  NP_001074664.11 
     710159905 
    chicken
    (Gallus gallus)
    Aves ARID4A1 AT rich interactive domain 4A (RBP1-like) 78.7(n)
    79.31(a)
      423541  NM_001012902.2  NP_001012920.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARID4A6
    AT rich interactive domain 4A (RBP1-like)
    70(a)
    1 ↔ 1
    GL343459.1(334861-397380)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.321702 Xenopus laevis transcribed sequence with moderate similarity more 77.54(n)    CA972142.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi14h032 Danio rerio, Similar to retinoblastoma binding protein more 76.86(n)    BC048031.1 
    worm
    (Caenorhabditis elegans)
    Secernentea arid-16
    Protein ARID-1 (arid-1) mRNA, complete cds
    17(a)
    1 → many
    V(186305-200686) WBGene00044689


    ENSEMBL Gene Tree for ARID4A (if available)
    TreeFam Gene Tree for ARID4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARID4A gene
    ARID4B2  ARID5A2  ARID5B2  
    1 SIMAP similar gene for ARID4A using alignment to 6 protein entries:     ARI4A_HUMAN (see all proteins):
    ARID4B

    Find genes that share paralogs with ARID4A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARID4A (see all 1331)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs350215841,2
    C--39791213(+) GAGAG-/A/AG  
            
    CATGA
    3 -- int11NA 2
    rs348000291,2
    C--58763222(+) ATGAC-/AGAG  
            
    AGAGA
    3 -- us2k10--------
    rs610285031,2
    C,F--58766900(+) TTTGGG/CGGATT 3 -- int11Minor allele frequency- C:0.50WA 2
    rs1456903751,2
    --58766990(+) CATTTC/TTTCTG 3 -- int10--------
    rs106303591,2
    C--58767085(+) ATACTTATACT/-
            
    AAAAA
    3 -- cds11Minor allele frequency- -:0.00NA 2
    rs3736301391,2
    C--58767085(+) AAAACA/TTATAC 3 -- int10--------
    rs759836491,2
    C--58767179(+) TGAATG/TCTGTG 3 -- int10--------
    rs1436847381,2
    --58767219(+) TTTGCA/CAAAAG 3 -- int10--------
    rs1882905191,2
    --58767344(+) TTTCTC/TGTGGT 3 -- int10--------
    rs1812564121,2
    --58767412(+) ACTTAC/TTAGAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for ARID4A (58765103 - 58840605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARID4A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901985CNV Loss21882294
    esv26881CNV Loss19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARID4A
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 180201    OMIM disorders: --

    1 disease for ARID4A:    
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    retinoblastoma


    Find genes that share disorders with ARID4A           About GenesLikeMe

    6 Novoseek inferred disease relationships for ARID4A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 77.3 19 10496363 (2), 8455946 (1), 14581478 (1), 17879257 (1) (see all 12)
    breast carcinoma 22.2 1 16479010 (1)
    breast cancer 21.1 4 10496363 (1), 14581478 (1), 16479010 (1)
    melanoma 6.68 1 14581478 (1)
    metastasis 0.0384 2 14581478 (1)
    tumors 0 2 11283269 (1), 15451426 (1)


    Export disorders for ARID4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARID4A gene, integrated from 10 sources (see all 46):
    (articles sorted by number of sources associating them with ARID4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites. (PubMed id 8455946)1, 2, 3, 9 Otterson G.A.... Kaye F.J. (Oncogene 1993)
    2. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. (PubMed id 1857421)1, 2, 3, 9 Defeo-Jones D.... Oliff A. (Nature 1991)
    3. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. (PubMed id 14581478)1, 2, 9 Meehan W.J.... Welch D.R. (J. Biol. Chem. 2004)
    4. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. (PubMed id 8414517)1, 2, 9 Fattaey A.R....Jones R.E. (Oncogene 1993)
    5. Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements. (PubMed id 16873370)1, 9 Monroe D.G....Spelsberg T.C. (J. Biol. Chem. 2006)
    6. RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. (PubMed id 10490602)1, 9 Lai A....Branton P.E. (Mol. Cell. Biol. 1999)
    7. RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. (PubMed id 11283269)1, 9 Lai A....Branton P.E. (Mol. Cell. Biol. 2001)
    8. RBP1 induces growth arrest by repression of E2F-dependent transcription. (PubMed id 10321733)1, 9 Lai A....Branton P.E. (Oncogene 1999)
    9. Recognition of an epitope of a breast cancer antigen by human antibody. (PubMed id 10369074)1, 9 Cao J....Irie R.F. (Breast Cancer Res. Treat. 1999)
    10. Identification and characterization of three new components of the mSin3A corepressor complex. (PubMed id 12724404)1, 9 Fleischer T.C.... Ayer D.E. (Mol. Cell. Biol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 5926 HGNC: 9885 AceView: ARID4A Ensembl:ENSG00000032219 euGenes: HUgn5926
    ECgene: ARID4A H-InvDB: ARID4A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARID4A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARID4A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARID4A gene:
    Search GeneIP for patents involving ARID4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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