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Aliases for ARID4A Gene

Aliases for ARID4A Gene

  • AT Rich Interactive Domain 4A (RBP1-Like) 2 3
  • Retinoblastoma-Binding Protein 1 2 3 4
  • RBBP1 3 4 6
  • RBP1 3 4 6
  • ARID Domain-Containing Protein 4A 3 4
  • RBBP-1 3 4
  • AT-Rich Interactive Domain-Containing Protein 4A 3
  • Retinoblastoma Binding Protein 1 3
  • RBP-1 3

External Ids for ARID4A Gene

Previous HGNC Symbols for ARID4A Gene

  • RBBP1

Previous GeneCards Identifiers for ARID4A Gene

  • GC14P056756
  • GC14P056757
  • GC14P057835
  • GC14P058766
  • GC14P038930

Summaries for ARID4A Gene

Entrez Gene Summary for ARID4A Gene

  • The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID4A Gene

ARID4A (AT Rich Interactive Domain 4A (RBP1-Like)) is a Protein Coding gene. Diseases associated with ARID4A include retinoblastoma. Among its related pathways are Signaling by GPCR and Disease. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ARID5A.

UniProtKB/Swiss-Prot for ARID4A Gene

  • Interacts with the viral protein-binding domain of the retinoblastoma protein

Gene Wiki entry for ARID4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID4A Gene

Genomics for ARID4A Gene

Regulatory Elements for ARID4A Gene

Transcription factor binding sites by QIAGEN in the ARID4A gene promoter:

Genomic Location for ARID4A Gene

Start:
58,298,385 bp from pter
End:
58,373,995 bp from pter
Size:
75,611 bases
Orientation:
Plus strand

Genomic View for ARID4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARID4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID4A Gene

Proteins for ARID4A Gene

  • Protein details for ARID4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P29374-ARI4A_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 4A
    Protein Accession:
    P29374
    Secondary Accessions:
    • Q15991
    • Q15992
    • Q15993

    Protein attributes for ARID4A Gene

    Size:
    1257 amino acids
    Molecular mass:
    142752 Da
    Quaternary structure:
    • Interacts with BRMS1. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, BRMS1, HDAC1 and HDAC2.

    Three dimensional structures from OCA and Proteopedia for ARID4A Gene

    Alternative splice isoforms for ARID4A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARID4A Gene

Proteomics data for ARID4A Gene at MOPED

Post-translational modifications for ARID4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARID4A Gene

Domains for ARID4A Gene

Suggested Antigen Peptide Sequences for ARID4A Gene

Graphical View of Domain Structure for InterPro Entry

P29374

UniProtKB/Swiss-Prot:

ARI4A_HUMAN :
  • P29374
Domain:
  • Contains 1 ARID domain.
genes like me logo Genes that share domains with ARID4A: view

No data available for Gene Families for ARID4A Gene

Function for ARID4A Gene

Molecular function for ARID4A Gene

UniProtKB/Swiss-Prot Function: Interacts with the viral protein-binding domain of the retinoblastoma protein

Gene Ontology (GO) - Molecular Function for ARID4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IDA 15640446
GO:0003700 sequence-specific DNA binding transcription factor activity TAS 8414517
GO:0044212 transcription regulatory region DNA binding IBA --
genes like me logo Genes that share ontologies with ARID4A: view
genes like me logo Genes that share phenotypes with ARID4A: view

Animal Models for ARID4A Gene

MGI Knock Outs for ARID4A:

miRNA for ARID4A Gene

miRTarBase miRNAs that target ARID4A

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARID4A Gene

Localization for ARID4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID4A Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID4A Gene COMPARTMENTS Subcellular localization image for ARID4A gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for ARID4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus TAS 8414517
GO:0005654 nucleoplasm TAS --
GO:0017053 transcriptional repressor complex IDA 11283269
genes like me logo Genes that share ontologies with ARID4A: view

Pathways for ARID4A Gene

genes like me logo Genes that share pathways with ARID4A: view

Gene Ontology (GO) - Biological Process for ARID4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006349 regulation of gene expression by genetic imprinting IEA --
GO:0006357 regulation of transcription from RNA polymerase II promoter IBA --
GO:0006366 transcription from RNA polymerase II promoter TAS 8414517
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with ARID4A: view

Compounds for ARID4A Gene

(1) Novoseek inferred chemical compound relationships for ARID4A Gene

Compound -log(P) Hits PubMed IDs
estrogen 2.97 3
genes like me logo Genes that share compounds with ARID4A: view

Transcripts for ARID4A Gene

Unigene Clusters for ARID4A Gene

AT rich interactive domain 4A (RBP1-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID4A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
SP1: -
SP2: - -
SP3:
SP4:
SP5:
SP6: - -
SP7: -
SP8: -
SP9:

Relevant External Links for ARID4A Gene

GeneLoc Exon Structure for
ARID4A
ECgene alternative splicing isoforms for
ARID4A

Expression for ARID4A Gene

mRNA expression in normal human tissues for ARID4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARID4A Gene

SOURCE GeneReport for Unigene cluster for ARID4A Gene Hs.161000

genes like me logo Genes that share expressions with ARID4A: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARID4A Gene

Orthologs for ARID4A Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID4A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID4A 35
  • 99.81 (n)
  • 99.76 (a)
ARID4A 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARID4A 35
  • 93.44 (n)
  • 93.71 (a)
ARID4A 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID4A 35
  • 92.87 (n)
  • 94.35 (a)
ARID4A 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arid4a 35
  • 84.99 (n)
  • 85.98 (a)
Arid4a 16
Arid4a 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARID4A 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARID4A 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arid4a 35
  • 82.61 (n)
  • 81.52 (a)
chicken
(Gallus gallus)
Aves ARID4A 35
  • 78.7 (n)
  • 79.31 (a)
ARID4A 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARID4A 36
  • 70 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.32170 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arid4a 35
  • 68.01 (n)
  • 64.41 (a)
Str.10513 35
zebrafish
(Danio rerio)
Actinopterygii arid4a 36
  • 52 (a)
OneToOne
wufi14h03 35
worm
(Caenorhabditis elegans)
Secernentea arid-1 36
  • 17 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6900 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
OneToMany
Species with no ortholog for ARID4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARID4A Gene

ENSEMBL:
Gene Tree for ARID4A (if available)
TreeFam:
Gene Tree for ARID4A (if available)

Paralogs for ARID4A Gene

Paralogs for ARID4A Gene

Selected SIMAP similar genes for ARID4A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ARID4A: view

Variants for ARID4A Gene

Sequence variations from dbSNP and Humsavar for ARID4A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs941752 -- 58,332,643(+) CTATG(A/G)TGTAA intron-variant
rs1051857 -- 58,353,766(+) AAGAC(G/T)CAGAA synonymous-codon, reference
rs1051858 - 58,364,424(+) AAAAA(A/G)CAGAA reference, missense
rs1051859 -- 58,366,049(+) GATCT(C/T)CCTGT synonymous-codon, reference, intron-variant
rs1051860 -- 58,371,950(+) TCATC(A/G)TCTCC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ARID4A Gene

Variant ID Type Subtype PubMed ID
nsv901985 CNV Loss 21882294
esv26881 CNV Loss 19812545

Relevant External Links for ARID4A Gene

HapMap Linkage Disequilibrium report
ARID4A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID4A Gene

Disorders for ARID4A Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARID4A Gene including...

Search for ARID4A Gene in MalaCards »

(6) Novoseek inferred disease relationships for ARID4A Gene

Disease -log(P) Hits PubMed IDs
retinoblastoma 77.3 13
breast carcinoma 22.2 1
breast cancer 21.1 3
melanoma 6.68 1
metastasis 0.0384 1
genes like me logo Genes that share disorders with ARID4A: view

No data available for UniProtKB/Swiss-Prot for ARID4A Gene

Publications for ARID4A Gene

  1. Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites. (PMID: 8455946) Otterson G.A. … Kaye F.J. (Oncogene 1993) 2 3 4 23
  2. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. (PMID: 1857421) Defeo-Jones D. … Oliff A. (Nature 1991) 2 3 4 23
  3. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. (PMID: 8414517) Fattaey A.R. … Jones R.E. (Oncogene 1993) 3 4 23
  4. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. (PMID: 14581478) Meehan W.J. … Welch D.R. (J. Biol. Chem. 2004) 3 4 23
  5. Identification and characterization of three new components of the mSin3A corepressor complex. (PMID: 12724404) Fleischer T.C. … Ayer D.E. (Mol. Cell. Biol. 2003) 3 23

Products for ARID4A Gene

Sources for ARID4A Gene

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