Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARID4A Gene

protein-coding   GIFtS: 55
GCID: GC14P058766

AT Rich Interactive Domain 4A (RBP1-Like)

(Previous name: retinoblastoma-binding protein 1)
(Previous symbol: RBBP1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
AT Rich Interactive Domain 4A (RBP1-Like)1 2     ARID Domain-Containing Protein 4A2 3
RBBP11 2 3 5     RBP-12
Retinoblastoma-Binding Protein 11 2 3     AT-Rich Interactive Domain-Containing Protein 4A2
RBP12 3 5     Retinoblastoma Binding Protein 12
RBBP-12 3     

External Ids:    HGNC: 98851   Entrez Gene: 59262   Ensembl: ENSG000000322197   OMIM: 1802015   UniProtKB: P293743   

Export aliases for ARID4A gene to outside databases

Previous GC identifers: GC14P056756 GC14P056757 GC14P057835 GC14P038930


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARID4A Gene:
The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several
other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription
by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in
addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional
repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not
all transcript variants have been fully described. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARID4A Gene: 
ARID4A (AT rich interactive domain 4A (RBP1-like)) is a protein-coding gene. Diseases associated with ARID4A include retinoblastoma, and prostate adenocarcinoma, and among its related super-pathways are Development NOTCH1-mediated pathway for NF-KB activity modulation. GO annotations related to this gene include DNA binding and sequence-specific DNA binding transcription factor activity. An important paralog of this gene is ARID4B.

UniProtKB/Swiss-Prot: ARI4A_HUMAN, P29374
Function: Interacts with the viral protein-binding domain of the retinoblastoma protein

Gene Wiki entry for ARID4A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARID4A gene promoter:
         USF1   Sp1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARID4A promoter sequence
   Search SABiosciences Chromatin IP Primers for ARID4A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARID4A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q22.3

ARID4A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARID4A gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P058766:  view genomic region     (about GC identifiers)

Start:
58,765,103 bp from pter      End:
58,840,605 bp from pter
Size:
75,503 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARI4A_HUMAN, P29374 (See protein sequence)
Recommended Name: AT-rich interactive domain-containing protein 4A  
Size: 1257 amino acids; 142752 Da
Subunit: Interacts with BRMS1. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4,
RBBP7, SAP30, BRMS1, HDAC1 and HDAC2
Subcellular location: Nucleus
3 PDB 3D structures from and Proteopedia for ARID4A:
2LCC (3D)        2LCD (3D)        2YRV (3D)    
Secondary accessions: Q15991 Q15992 Q15993
Alternative splicing: 3 isoforms:  P29374-1   P29374-2   P29374-3   

Explore the universe of human proteins at neXtProt for ARID4A: NX_P29374

Explore proteomics data for ARID4A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P29374

  • ARID4A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARID4A Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_002883.3  NP_075376.2  NP_075377.2  

    ENSEMBL proteins: 
     ENSP00000347602   ENSP00000378597   ENSP00000410417   ENSP00000392567   ENSP00000415872  
     ENSP00000397368   ENSP00000416053   ENSP00000344556  

    Human Recombinant Protein Products for ARID4A: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for ARID4A
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ARID4A
    GenScript Custom Purified and Recombinant Proteins Services for ARID4A
    Novus Biologicals ARID4A Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARID4A 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus TAS8414517
    GO:0017053transcriptional repressor complex IDA11283269

    ARID4A for ontologies           About GeneDecksing



    ARID4A Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARID4A
    GenScript Custom Superior Antibodies Services for ARID4A
    Novus Biologicals ARID4A Antibodies
    Abcam antibodies for ARID4A
    Cloud-Clone Corp. Antibodies for ARID4A 
    ThermoFisher Antibodies for ARID4A
    LSBio Antibodies in human, mouse, rat for ARID4A 

    Assay Products for ARID4A: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARID4A
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARID4A
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARID4A 
    Cloud-Clone Corp. CLIAs for ARID4A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR000953 Chromo_domain/shadow
     IPR016197 Chromodomain-like
     IPR025995 Tudor-knot
     IPR002999 Tudor
     IPR001606 ARID/BRIGHT_DNA-bd

    Graphical View of Domain Structure for InterPro Entry P29374

    ProtoNet protein and cluster: P29374

    4 Blocks protein domains:
    IPB000953 Chromo domain
    IPB001606 ARID (AT-rich interaction domain) protein
    IPB002999 Tudor domain
    IPB012603 RBB1NT


    UniProtKB/Swiss-Prot: ARI4A_HUMAN, P29374
    Similarity: Contains 1 ARID domain


    ARID4A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARI4A_HUMAN, P29374
    Function: Interacts with the viral protein-binding domain of the retinoblastoma protein

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity TAS8414517
         
    ARID4A for ontologies           About GeneDecksing


    Phenotypes:
         15/16 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Arid4a) (see all 16):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  growth/size 
     hematopoietic system  homeostasis/metabolism  immune system  integument  liver/biliary system 
     mortality/aging  renal/urinary system  reproductive system  respiratory system  skeleton 

    ARID4A for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arid4atm1Alb for ARID4A

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARID4A 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARID4A

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARID4A 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARID4A 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARID4A
    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate ARID4A (see all 85):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-519a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidARID4A 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARID4A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARID4A

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARID4A
    Sirion Biotech Customized adenovirus for overexpression of ARID4A

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ARID4A (see all 16)
    OriGene ORF clones in mouse, rat for ARID4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ARID4A (NM_002892)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARID4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARID4A
    Sirion Biotech Customized lentivirus for stable overexpression of ARID4A 
                         Customized lentivirus expression plasmids for stable overexpression of ARID4A 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARID4A
    Search LifeMap BioReagents cell lines for ARID4A
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARID4A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARID4A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Development NOTCH1-mediated pathway for NF-KB activity modulation
    Transcription Sin3 and NuRD in transcription regulation0.35

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for ARID4A
        Transcription Sin3 and NuRD in transcription regulation


    1 GeneGo (Thomson Reuters) Pathway for ARID4A
        Transcription Sin3 and NuRD in transcription regulation



    ARID4A for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARID4A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/29 Interacting proteins for ARID4A (P293743 ENSP000003476024) via UniProtKB, MINT, STRING, and/or I2D (see all 29)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCNA2P202483, ENSP000002740264I2D: score=1 STRING: ENSP00000274026
    CDK2P249413, ENSP000002669704I2D: score=1 STRING: ENSP00000266970
    RBBP4Q090283, ENSP000003625924I2D: score=1 STRING: ENSP00000362592
    SAP30O754463, ENSP000002965044I2D: score=1 STRING: ENSP00000296504
    SIN3BO751823, ENSP000003691314I2D: score=1 STRING: ENSP00000369131
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006349regulation of gene expression by genetic imprinting IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS8414517
    GO:0034773histone H4-K20 trimethylation IEA--
    GO:0036124histone H3-K9 trimethylation IEA--
    GO:0045892negative regulation of transcription, DNA-dependent IDA12724404

    ARID4A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARID4A for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARID4A (ARI4A)

    1 Novoseek inferred chemical compound relationship for ARID4A gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    estrogen 2.97 4 16873370 (2), 15802376 (1)

    Search CenterWatch for drugs/clinical trials and news about ARID4A / ARI4A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARID4A gene (3 alternative transcripts): 
    NM_002892.3  NM_023000.2  NM_023001.2  

    Unigene Cluster for ARID4A:

    AT rich interactive domain 4A (RBP1-like)
    Hs.161000  [show with all ESTs]
    Unigene Representative Sequence: NM_002892
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000355431(uc001xdo.3 uc001xdp.3 uc001xdq.3) ENST00000395168
    ENST00000431612(uc010apf.1) ENST00000445108 ENST00000424658 ENST00000431317
    ENST00000417477(uc010apg.1) ENST00000553355 ENST00000469635 ENST00000466065
    ENST00000348476
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARID4A
    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate ARID4A (see all 85):
    hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-938 hsa-miR-30d hsa-miR-519a hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidARID4A 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARID4A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARID4A
    Clone
    Products:
         
    OriGene clones in human, mouse for ARID4A (see all 16)
    OriGene ORF clones in mouse, rat for ARID4A
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ARID4A (NM_002892)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARID4A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARID4A
    Sirion Biotech Customized lentivirus for stable overexpression of ARID4A 
                         Customized lentivirus expression plasmids for stable overexpression of ARID4A 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ARID4A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARID4A
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARID4A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARID4A

    Additional mRNA sequence: 

    AF086075.1 AK307520.1 AK307972.1 BC026230.1 S57153.1 S57160.1 S57162.1 S66427.1 

    13 DOTS entries:

    DT.305572  DT.70100576  DT.95166579  DT.92426621  DT.100766938  DT.427233  DT.92426622  DT.91892297 
    DT.95153366  DT.86849476  DT.92426623  DT.95152704  DT.95166581 

    24/101 AceView cDNA sequences (see all 101):

    AL700599 AL699636 AV660033 AF086075 C01408 BG942986 N48365 AW162962 
    AI246187 BG941641 CB156934 BE618019 BQ439648 AI436281 AW949879 BX510119 
    BC026230 CA945122 BQ922162 BE882846 AW473272 BX504085 H88595 CD676697 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for ARID4A (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
    SP1:              -                                                                                                                                             
    SP2:              -                 -                                                                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            


    ECgene alternative splicing isoforms for ARID4A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARID4A expression in normal human tissues (normalized intensities)      ARID4A embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARID4A Expression
    About this image


    ARID4A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 3 entries
             pre Conventional Dendritic Cells Peripheral Blood
             neutrophils   
     
     Brain (Nervous System)    fully expand to see all 3 entries
             posterior singulate   

    See ARID4A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARID4A

    SOURCE GeneReport for Unigene cluster: Hs.161000
        SABiosciences Custom PCR Arrays for ARID4A
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ARID4A
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARID4A
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARID4A
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARID4A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARID4A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARID4A gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arid4a1 , 5 AT rich interactive domain 4A (RBP1-like)1, 5 82.24(n)1
    81.53(a)1
      12 (29.39 cM)5
    2382471  NM_001081195.11  NP_001074664.11 
     710159905 
    chicken
    (Gallus gallus)
    Aves ARID4A1 AT rich interactive domain 4A (RBP1-like) 77.97(n)
    77.03(a)
      423541  NM_001012902.1  NP_001012920.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARID4A6
    AT rich interactive domain 4A (RBP1-like)
    70(a)
    1 ↔ 1
    GL343459.1(334861-397380)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.321702 Xenopus laevis transcribed sequence with moderate similarity more 77.54(n)    CA972142.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi14h032 Danio rerio, Similar to retinoblastoma binding protein more 76.86(n)    BC048031.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG344226
    --
    14(a)
    1 → many
    X(18737696-18749891)
    worm
    (Caenorhabditis elegans)
    Secernentea arid-16
    Protein ARID-1
    16(a)
    1 → many
    V(186305-200686)


    ENSEMBL Gene Tree for ARID4A (if available)
    TreeFam Gene Tree for ARID4A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARID4A gene
    ARID4B2  ARID5A2  ARID5B2  
    1 SIMAP similar gene for ARID4A using alignment to 6 protein entries:     ARI4A_HUMAN (see all proteins):
    ARID4B

    ARID4A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1331 SNPs in ARID4A are shown (see all 1331)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs350215841,2
    C--39791213(+) GAGAG-/A/AG  
            
    CATGA
    3 -- int11NA 2
    rs348000291,2
    C--58763222(+) ATGAC-/AGAG  
            
    AGAGA
    3 -- us2k10--------
    rs610285031,2
    C,F--58766900(+) TTTGGG/CGGATT 3 -- int11Minor allele frequency- C:0.50WA 2
    rs1456903751,2
    --58766990(+) CATTTC/TTTCTG 3 -- int10--------
    rs106303591,2
    C--58767085(+) ATACTTATACT/-
            
    AAAAA
    3 -- cds11Minor allele frequency- -:0.00NA 2
    rs3736301391,2
    C--58767085(+) AAAACA/TTATAC 3 -- int10--------
    rs759836491,2
    C--58767179(+) TGAATG/TCTGTG 3 -- int10--------
    rs1436847381,2
    --58767219(+) TTTGCA/CAAAAG 3 -- int10--------
    rs1882905191,2
    --58767344(+) TTTCTC/TGTGGT 3 -- int10--------
    rs1812564121,2
    --58767412(+) ACTTAC/TTAGAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for ARID4A (58765103 - 58840605 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARID4A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv901985CNV Loss21882294
    esv26881CNV Loss19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARID4A
    DNA2.0 Custom Variant and Variant Library Synthesis for ARID4A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 180201    OMIM disorders: --

    10 diseases for ARID4A:    About MalaCards
    retinoblastoma    prostate adenocarcinoma    cholangiocarcinoma    intrahepatic cholangiocarcinoma
    osteosarcoma    neuroblastoma    breast cancer    gastric cancer
    adenocarcinoma    prostatitis


    ARID4A for disorders           About GeneDecksing

    6 Novoseek inferred disease relationships for ARID4A gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    retinoblastoma 77.3 19 10496363 (2), 8455946 (1), 14581478 (1), 17879257 (1) (see all 12)
    breast carcinoma 22.2 1 16479010 (1)
    breast cancer 21.1 4 10496363 (1), 14581478 (1), 16479010 (1)
    melanoma 6.68 1 14581478 (1)
    metastasis 0.0384 2 14581478 (1)
    tumors 0 2 11283269 (1), 15451426 (1)


    Export disorders for ARID4A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARID4A gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with ARID4A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites. (PubMed id 8455946)1, 2, 3, 9 Otterson G.A.... Kaye F.J. (1993)
    2. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. (PubMed id 1857421)1, 2, 3, 9 Defeo-Jones D.... Oliff A. (1991)
    3. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. (PubMed id 14581478)1, 2, 9 Meehan W.J....Welch D.R. (2004)
    4. Characterization of the retinoblastoma binding proteins RBP1 and RBP2. (PubMed id 8414517)1, 2, 9 Fattaey A.R....Jones R.E. (1993)
    5. Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements. (PubMed id 16873370)1, 9 Monroe D.G....Spelsberg T.C. (2006)
    6. RBP1 recruits both histone deacetylase-dependent and -independent repression activities to retinoblastoma family proteins. (PubMed id 10490602)1, 9 Lai A....Branton P.E. (1999)
    7. RBP1 recruits the mSIN3-histone deacetylase complex to the pocket of retinoblastoma tumor suppressor family proteins found in limited discrete regions of the nucleus at growth arrest. (PubMed id 11283269)1, 9 Lai A....Branton P.E. (2001)
    8. RBP1 induces growth arrest by repression of E2F-dependent transcription. (PubMed id 10321733)1, 9 Lai A....Branton P.E. (1999)
    9. Recognition of an epitope of a breast cancer antigen by human antibody. (PubMed id 10369074)1, 9 Cao J....Irie R.F. (1999)
    10. Identification and characterization of three new components of the mSin3A corepressor complex. (PubMed id 12724404)1, 9 Fleischer T.C....Ayer D.E. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5926 HGNC: 9885 AceView: ARID4A Ensembl:ENSG00000032219 euGenes: HUgn5926
    ECgene: ARID4A H-InvDB: ARID4A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARID4A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARID4A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARID4A gene:
    Search GeneIP for patents involving ARID4A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ARID4A  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ARID4A  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ARID4A  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARID4A   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ARID4A   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARID4A   OriGene Custom Protein Services for ARID4A  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARID4A
     QIAGEN SeqTarget long-range PCR primers for resequencing ARID4A
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARID4A
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARID4A
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARID4A
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARID4A
     GenScript Custom Purified and Recombinant Proteins Services for ARID4A GenScript cDNA clones with any tag delivered in your preferred vector for ARID4A
     GenScript Custom Assay Services for ARID4A GenScript Custom Superior Antibodies Services for ARID4A
     GenScript Custom overexpressing Cell Line Services for ARID4A CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARID4A promoter
     Search Chromatin IP Primers for ARID4A
     RT2 qPCR Primer Assay in human, mouse, rat ARID4A
     GNC Network for ARID4A
     SABiosciences Custom PCR Arrays for ARID4A
     Search Tocris compounds for ARID4A (ARI4A)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARID4A antibodies
     ARID4A proteins
     Antibodies for ARID4A
     See all of Abcam's Antibodies, Kits and Proteins for ARID4A
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ARID4A
     Antibodies for ARID4A
     ELISAs for ARID4A
     CLIAs for ARID4A
     Search LifeMap BioReagents cell lines for ARID4A
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARID4A
     SwitchGear 3'UTR luciferase reporter plasmids for ARID4A
     SwitchGear Promoter luciferase reporter plasmids for ARID4A
     ThermoFisher Antibodies for ARID4A
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARID4A
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ARID4A
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARID4A
    Customized:
     lentivirus for stable overexpression of ARID4A
     lentivirus expression plasmids for stable overexpression of ARID4A
     adenovirus for overexpression of ARID4A
     LSBio Antibodies in human, mouse, rat for ARID4A
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARID4A gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4