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Aliases for ARID4A Gene

Aliases for ARID4A Gene

  • AT-Rich Interaction Domain 4A 2 3 5
  • Retinoblastoma-Binding Protein 1 2 3 4
  • AT Rich Interactive Domain 4A (RBP1-Like) 2 3
  • ARID Domain-Containing Protein 4A 3 4
  • RBBP-1 3 4
  • RBBP1 3 4
  • RBP1 3 4
  • Retinoblastoma Binding Protein 1 3
  • RBP-1 3

External Ids for ARID4A Gene

Previous HGNC Symbols for ARID4A Gene

  • RBBP1

Previous GeneCards Identifiers for ARID4A Gene

  • GC14P056756
  • GC14P056757
  • GC14P057835
  • GC14P058766
  • GC14P038930

Summaries for ARID4A Gene

Entrez Gene Summary for ARID4A Gene

  • The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID4A Gene

ARID4A (AT-Rich Interaction Domain 4A) is a Protein Coding gene. Diseases associated with ARID4A include Retinoblastoma. Among its related pathways are Chromatin organization and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is ARID1A.

UniProtKB/Swiss-Prot for ARID4A Gene

  • Interacts with the viral protein-binding domain of the retinoblastoma protein.

Gene Wiki entry for ARID4A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID4A Gene

Genomics for ARID4A Gene

Regulatory Elements for ARID4A Gene

Enhancers for ARID4A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARID4A on UCSC Golden Path with GeneCards custom track

Promoters for ARID4A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARID4A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the ARID4A gene promoter:

Genomic Location for ARID4A Gene

58,298,385 bp from pter
58,373,995 bp from pter
75,611 bases
Plus strand

Genomic View for ARID4A Gene

Genes around ARID4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARID4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARID4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID4A Gene

Proteins for ARID4A Gene

  • Protein details for ARID4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    AT-rich interactive domain-containing protein 4A
    Protein Accession:
    Secondary Accessions:
    • Q15991
    • Q15992
    • Q15993

    Protein attributes for ARID4A Gene

    1257 amino acids
    Molecular mass:
    142752 Da
    Quaternary structure:
    • Interacts with BRMS1. Identified in mSin3A corepressor complexes together with SIN3A, SIN3B, RBBP4, RBBP7, SAP30, BRMS1, HDAC1 and HDAC2.

    Three dimensional structures from OCA and Proteopedia for ARID4A Gene

    Alternative splice isoforms for ARID4A Gene


neXtProt entry for ARID4A Gene

Proteomics data for ARID4A Gene at MOPED

Post-translational modifications for ARID4A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARID4A Gene

Domains & Families for ARID4A Gene

Gene Families for ARID4A Gene

Suggested Antigen Peptide Sequences for ARID4A Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ARID domain.
  • Contains 1 ARID domain.
genes like me logo Genes that share domains with ARID4A: view

Function for ARID4A Gene

Molecular function for ARID4A Gene

UniProtKB/Swiss-Prot Function:
Interacts with the viral protein-binding domain of the retinoblastoma protein.
genes like me logo Genes that share phenotypes with ARID4A: view

Animal Models for ARID4A Gene

MGI Knock Outs for ARID4A:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARID4A Gene

Localization for ARID4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID4A Gene

Subcellular locations from

Jensen Localization Image for ARID4A Gene COMPARTMENTS Subcellular localization image for ARID4A gene
Compartment Confidence
nucleus 5
cytosol 1

No data available for Gene Ontology (GO) - Cellular Components for ARID4A Gene

Pathways & Interactions for ARID4A Gene

genes like me logo Genes that share pathways with ARID4A: view

Pathways by source for ARID4A Gene

1 GeneGo (Thomson Reuters) pathway for ARID4A Gene

SIGNOR curated interactions for ARID4A Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for ARID4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006325 chromatin organization TAS --
GO:0006349 regulation of gene expression by genetic imprinting IEA --
GO:0007283 spermatogenesis IEA --
GO:0016575 histone deacetylation TAS --
GO:0034773 histone H4-K20 trimethylation IEA --
genes like me logo Genes that share ontologies with ARID4A: view

Drugs & Compounds for ARID4A Gene

(1) Drugs for ARID4A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with ARID4A: view

Transcripts for ARID4A Gene

Unigene Clusters for ARID4A Gene

AT rich interactive domain 4A (RBP1-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID4A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
SP1: -
SP2: - -
SP6: - -
SP7: -
SP8: -

Relevant External Links for ARID4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARID4A Gene

mRNA expression in normal human tissues for ARID4A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARID4A Gene

This gene is overexpressed in Adrenal (23.4), Peripheral blood mononuclear cells (10.3), CD8 Tcells (9.3), and Blymphocyte (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARID4A Gene

SOURCE GeneReport for Unigene cluster for ARID4A Gene Hs.161000

genes like me logo Genes that share expression patterns with ARID4A: view

Protein tissue co-expression partners for ARID4A Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARID4A Gene

Orthologs for ARID4A Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID4A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARID4A 35
  • 93.44 (n)
  • 93.71 (a)
  • 93 (a)
(Canis familiaris)
Mammalia ARID4A 35
  • 92.87 (n)
  • 94.35 (a)
  • 94 (a)
(Mus musculus)
Mammalia Arid4a 35
  • 84.99 (n)
  • 85.98 (a)
Arid4a 16
Arid4a 36
  • 86 (a)
(Pan troglodytes)
Mammalia ARID4A 35
  • 99.81 (n)
  • 99.76 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Arid4a 35
  • 82.61 (n)
  • 81.52 (a)
(Monodelphis domestica)
Mammalia ARID4A 36
  • 81 (a)
(Ornithorhynchus anatinus)
Mammalia ARID4A 36
  • 74 (a)
(Gallus gallus)
Aves ARID4A 35
  • 78.7 (n)
  • 79.31 (a)
  • 78 (a)
(Anolis carolinensis)
Reptilia ARID4A 36
  • 70 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arid4a 35
  • 68.01 (n)
  • 64.41 (a)
Str.10513 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32170 35
(Danio rerio)
Actinopterygii wufi14h03 35
arid4a 36
  • 52 (a)
(Caenorhabditis elegans)
Secernentea arid-1 36
  • 17 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6900 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for ARID4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARID4A Gene

Gene Tree for ARID4A (if available)
Gene Tree for ARID4A (if available)

Paralogs for ARID4A Gene

Paralogs for ARID4A Gene

(1) SIMAP similar genes for ARID4A Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with ARID4A: view

Variants for ARID4A Gene

Sequence variations from dbSNP and Humsavar for ARID4A Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs34982206 - 58,347,709(+) TCATC(A/C)CCATG reference, missense
rs2230098 - 58,364,260(+) AAAAA(A/G)TGAAA reference, missense
rs1051858 - 58,364,424(+) AAAAA(A/G)CAGAA reference, missense
rs7141038 -- 58,332,091(+) AATTG(G/T)AAGTA intron-variant
rs2754222 -- 58,337,246(+) TTtat(A/T)tatat intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID4A Gene

Variant ID Type Subtype PubMed ID
nsv901985 CNV Loss 21882294
esv26881 CNV Loss 19812545

Variation tolerance for ARID4A Gene

Residual Variation Intolerance Score: 10.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARID4A Gene

Disorders for ARID4A Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARID4A Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • retinoblastoma, trilateral
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARID4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARID4A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARID4A Gene

Publications for ARID4A Gene

  1. Alternative splicing of the RBP1 gene clusters in an internal exon that encodes potential phosphorylation sites. (PMID: 8455946) Otterson G.A. … Kaye F.J. (Oncogene 1993) 2 3 4 23 67
  2. Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product. (PMID: 1857421) Defeo-Jones D. … Oliff A. (Nature 1991) 2 3 23
  3. Estrogen receptor isoform-specific regulation of the retinoblastoma-binding protein 1 (RBBP1) gene: roles of AF1 and enhancer elements. (PMID: 16873370) Monroe D.G. … Spelsberg T.C. (J. Biol. Chem. 2006) 3 23
  4. Breast cancer metastasis suppressor 1 (BRMS1) forms complexes with retinoblastoma-binding protein 1 (RBP1) and the mSin3 histone deacetylase complex and represses transcription. (PMID: 14581478) Meehan W.J. … Welch D.R. (J. Biol. Chem. 2004) 3 23
  5. Identification and characterization of three new components of the mSin3A corepressor complex. (PMID: 12724404) Fleischer T.C. … Ayer D.E. (Mol. Cell. Biol. 2003) 3 23

Products for ARID4A Gene

Sources for ARID4A Gene