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Aliases for ARID3C Gene

Aliases for ARID3C Gene

  • AT-Rich Interaction Domain 3C 2 3 5
  • AT Rich Interactive Domain 3C (BRIGHT-Like) 2 3
  • ARID Domain-Containing Protein 3C 3 4
  • AT Rich Interactive Domain 3C (BRIGHT- Like) 2
  • Brightlike 3

External Ids for ARID3C Gene

Previous GeneCards Identifiers for ARID3C Gene

  • GC09U900405
  • GC09M034612
  • GC09M034613
  • GC09M034575

Summaries for ARID3C Gene

Entrez Gene Summary for ARID3C Gene

  • This gene is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID3C Gene

ARID3C (AT-Rich Interaction Domain 3C) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is ARID1A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID3C Gene

Genomics for ARID3C Gene

Regulatory Elements for ARID3C Gene

Genomic Location for ARID3C Gene

Chromosome:
9
Start:
34,621,286 bp from pter
End:
34,628,950 bp from pter
Size:
7,665 bases
Orientation:
Minus strand

Genomic View for ARID3C Gene

Genes around ARID3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARID3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARID3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID3C Gene

Proteins for ARID3C Gene

  • Protein details for ARID3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKF2-ARI3C_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 3C
    Protein Accession:
    A6NKF2

    Protein attributes for ARID3C Gene

    Size:
    412 amino acids
    Molecular mass:
    44073 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARID3C Gene

Proteomics data for ARID3C Gene at MOPED

Post-translational modifications for ARID3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARID3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARID3C Gene

Domains & Families for ARID3C Gene

Gene Families for ARID3C Gene

Protein Domains for ARID3C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARID3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKF2

UniProtKB/Swiss-Prot:

ARI3C_HUMAN :
  • Contains 1 ARID domain.
Domain:
  • Contains 1 ARID domain.
  • Contains 1 REKLES domain.
genes like me logo Genes that share domains with ARID3C: view

Function for ARID3C Gene

Gene Ontology (GO) - Molecular Function for ARID3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with ARID3C: view
genes like me logo Genes that share phenotypes with ARID3C: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARID3C Gene

Localization for ARID3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID3C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID3C Gene COMPARTMENTS Subcellular localization image for ARID3C gene
Compartment Confidence
nucleus 4
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

No data available for Gene Ontology (GO) - Cellular Components for ARID3C Gene

Pathways & Interactions for ARID3C Gene

SuperPathways for ARID3C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARID3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ARID3C: view

No data available for Pathways by source and SIGNOR curated interactions for ARID3C Gene

Drugs & Compounds for ARID3C Gene

No Compound Related Data Available

Transcripts for ARID3C Gene

mRNA/cDNA for ARID3C Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARID3C Gene

AT rich interactive domain 3C (BRIGHT-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID3C Gene

No ASD Table

Relevant External Links for ARID3C Gene

GeneLoc Exon Structure for
ARID3C
ECgene alternative splicing isoforms for
ARID3C

Expression for ARID3C Gene

mRNA expression in normal human tissues for ARID3C Gene

mRNA differential expression in normal tissues according to GTEx for ARID3C Gene

This gene is overexpressed in Liver (x16.6).

Protein differential expression in normal tissues from HIPED for ARID3C Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARID3C Gene



SOURCE GeneReport for Unigene cluster for ARID3C Gene Hs.534549

genes like me logo Genes that share expression patterns with ARID3C: view

Protein tissue co-expression partners for ARID3C Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARID3C Gene

Orthologs for ARID3C Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID3C 36
  • 99 (a)
OneToOne
ARID3C 35
  • 99.57 (n)
  • 99.02 (a)
cow
(Bos Taurus)
Mammalia ARID3C 35
  • 85.7 (n)
  • 85.78 (a)
ARID3C 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID3C 36
  • 89 (a)
OneToOne
ARID3C 35
  • 87.12 (n)
  • 88.38 (a)
mouse
(Mus musculus)
Mammalia Arid3c 16
Arid3c 36
  • 86 (a)
OneToOne
Arid3c 35
  • 82.32 (n)
  • 84.52 (a)
oppossum
(Monodelphis domestica)
Mammalia ARID3C 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARID3C 36
  • 88 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arid3c 35
  • 83.21 (n)
  • 85.06 (a)
chicken
(Gallus gallus)
Aves ARID3C 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARID3C 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ARID3C 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta retn 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfi-1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6971 36
  • 28 (a)
OneToMany
Species with no ortholog for ARID3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARID3C Gene

ENSEMBL:
Gene Tree for ARID3C (if available)
TreeFam:
Gene Tree for ARID3C (if available)

Paralogs for ARID3C Gene

Paralogs for ARID3C Gene

(2) SIMAP similar genes for ARID3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARID3C: view

Variants for ARID3C Gene

Sequence variations from dbSNP and Humsavar for ARID3C Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
VAR_043033 -
VAR_043034 -
rs7018560 -- 34,623,448(+) GACTC(A/G)GCTGA reference, missense
rs10122190 -- 34,626,109(+) CCCTC(C/T)GGGGC intron-variant, upstream-variant-2KB
rs10046833 -- 34,630,895(+) ACTGT(C/T)GGTAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARID3C Gene

Variant ID Type Subtype PubMed ID
nsv893038 CNV Loss 21882294
nsv818699 CNV Gain 17921354
nsv893039 CNV Loss 21882294

Variation tolerance for ARID3C Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARID3C Gene

HapMap Linkage Disequilibrium report
ARID3C
Human Gene Mutation Database (HGMD)
ARID3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID3C Gene

Disorders for ARID3C Gene

Relevant External Links for ARID3C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARID3C

No disorders were found for ARID3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARID3C Gene

Publications for ARID3C Gene

  1. Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription. (PMID: 21955986) Tidwell J.A. … Tucker P.W. (Mol. Immunol. 2011) 3 67
  2. Nomenclature of the ARID family of DNA-binding proteins. (PMID: 15922553) Wilsker D. … Moran E. (Genomics 2005) 3
  3. ARID proteins: a diverse family of DNA binding proteins implicated in the control of cell growth, differentiation, and development. (PMID: 11959810) Wilsker D. … Moran E. (Cell Growth Differ. 2002) 3
  4. ARID proteins come in from the desert. (PMID: 10838570) Kortschak R.D. … Saint R. (Trends Biochem. Sci. 2000) 3

Products for ARID3C Gene

Sources for ARID3C Gene

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