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Aliases for ARID3C Gene

Aliases for ARID3C Gene

  • AT-Rich Interaction Domain 3C 2 3 5
  • AT Rich Interactive Domain 3C (BRIGHT-Like) 2 3
  • ARID Domain-Containing Protein 3C 3 4
  • AT-Rich Interactive Domain-Containing Protein 3C 3
  • AT Rich Interactive Domain 3C (BRIGHT- Like) 2
  • Brightlike 3

External Ids for ARID3C Gene

Previous GeneCards Identifiers for ARID3C Gene

  • GC09U900405
  • GC09M034612
  • GC09M034613
  • GC09M034575

Summaries for ARID3C Gene

Entrez Gene Summary for ARID3C Gene

  • This gene is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID3C Gene

ARID3C (AT-Rich Interaction Domain 3C) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is ARID3A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID3C Gene

Genomics for ARID3C Gene

Regulatory Elements for ARID3C Gene

Enhancers for ARID3C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F034575 1.2 FANTOM5 Ensembl ENCODE 12.1 +50.7 50723 5.1 ZNF263 CTCF RNF2 CBX2 REST ZFHX2 JUND ZNF366 POLR2A ZNF341 GALT RPP25L ENSG00000230074 ENHO FAM219A ENSG00000232983 ARID3C CNTFR ENSG00000230729 SIGMAR1
GH09F034512 1.1 Ensembl ENCODE 10.2 +115.6 115587 1.3 CTCF SOX13 RAD21 THRB RARA ZNF335 FOXK2 RERE NR2F6 ZNF652 CNTFR FAM219A DNAI1 RPP25L ARID3C GALT SIGMAR1 FANCG PIR54959 RN7SKP24
GH09F034501 0.9 Ensembl ENCODE 10.2 +126.6 126614 0.9 CTCF KLF1 NFIA MIER2 RAD21 ZFHX2 SMC3 EGR2 FAM219A ENSG00000232983 CNTFR-AS1 DNAI1 RPP25L ARID3C GALT SIGMAR1 FANCG PIR54959
GH09F034675 0.8 ENCODE 11.2 -46.3 -46299 0.2 ELF3 CTCF CBX3 MAX ARID4B ZSCAN9 RAD21 RFX5 SLC30A9 SMC3 ENSG00000230074 IL11RA GALT CCL21 ARID3C PIR49106 LOC730098
GH09F034430 0.8 Ensembl ENCODE 10.6 +197.9 197934 0.4 KLF16 MIER1 GLIS1 SIN3A MIER2 REST DNAI1 FAM219A ENSG00000230729 RPP25L ENHO ARID3C GALT SIGMAR1 DCTN3 C9orf24
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARID3C on UCSC Golden Path with GeneCards custom track

Genomic Location for ARID3C Gene

Chromosome:
9
Start:
34,621,286 bp from pter
End:
34,628,950 bp from pter
Size:
7,665 bases
Orientation:
Minus strand

Genomic View for ARID3C Gene

Genes around ARID3C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARID3C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARID3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID3C Gene

Proteins for ARID3C Gene

  • Protein details for ARID3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKF2-ARI3C_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 3C
    Protein Accession:
    A6NKF2

    Protein attributes for ARID3C Gene

    Size:
    412 amino acids
    Molecular mass:
    44073 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARID3C Gene

Post-translational modifications for ARID3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARID3C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARID3C Gene

Domains & Families for ARID3C Gene

Gene Families for ARID3C Gene

Protein Domains for ARID3C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARID3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKF2

UniProtKB/Swiss-Prot:

ARI3C_HUMAN :
  • Contains 1 ARID domain.
Domain:
  • Contains 1 ARID domain.
  • Contains 1 REKLES domain.
genes like me logo Genes that share domains with ARID3C: view

Function for ARID3C Gene

Gene Ontology (GO) - Molecular Function for ARID3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IBA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
genes like me logo Genes that share ontologies with ARID3C: view
genes like me logo Genes that share phenotypes with ARID3C: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARID3C Gene

Localization for ARID3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID3C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARID3C gene
Compartment Confidence
nucleus 4
mitochondrion 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for ARID3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
GO:0005737 cytoplasm IEA --
GO:0045121 membrane raft IDA 21955986
genes like me logo Genes that share ontologies with ARID3C: view

Pathways & Interactions for ARID3C Gene

SuperPathways for ARID3C Gene

No Data Available

Interacting Proteins for ARID3C Gene

Gene Ontology (GO) - Biological Process for ARID3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ARID3C: view

No data available for Pathways by source and SIGNOR curated interactions for ARID3C Gene

Transcripts for ARID3C Gene

mRNA/cDNA for ARID3C Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARID3C Gene

AT rich interactive domain 3C (BRIGHT-like):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARID3C Gene

No ASD Table

Relevant External Links for ARID3C Gene

GeneLoc Exon Structure for
ARID3C
ECgene alternative splicing isoforms for
ARID3C

Expression for ARID3C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARID3C Gene

mRNA differential expression in normal tissues according to GTEx for ARID3C Gene

This gene is overexpressed in Liver (x16.6).

Protein differential expression in normal tissues from HIPED for ARID3C Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARID3C Gene



Protein tissue co-expression partners for ARID3C Gene

NURSA nuclear receptor signaling pathways regulating expression of ARID3C Gene:

ARID3C

SOURCE GeneReport for Unigene cluster for ARID3C Gene:

Hs.534549
genes like me logo Genes that share expression patterns with ARID3C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARID3C Gene

Orthologs for ARID3C Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID3C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID3C 34 35
  • 99.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARID3C 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID3C 34 35
  • 87.12 (n)
cow
(Bos Taurus)
Mammalia ARID3C 34 35
  • 85.7 (n)
rat
(Rattus norvegicus)
Mammalia Arid3c 34
  • 83.21 (n)
mouse
(Mus musculus)
Mammalia Arid3c 34 16 35
  • 82.32 (n)
oppossum
(Monodelphis domestica)
Mammalia ARID3C 35
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARID3C 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARID3C 35
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ARID3C 35
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta retn 35
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfi-1 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6971 35
  • 28 (a)
OneToMany
Species where no ortholog for ARID3C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARID3C Gene

ENSEMBL:
Gene Tree for ARID3C (if available)
TreeFam:
Gene Tree for ARID3C (if available)

Paralogs for ARID3C Gene

Paralogs for ARID3C Gene

(2) SIMAP similar genes for ARID3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARID3C: view

Variants for ARID3C Gene

Sequence variations from dbSNP and Humsavar for ARID3C Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10046833 -- 34,630,895(+) ACTGT(C/T)GGTAC utr-variant-5-prime
rs10046843 -- 34,631,162(+) GGTGG(C/T)CAGAG utr-variant-5-prime
rs10122190 -- 34,626,109(+) CCCTC(C/T)GGGGC intron-variant
rs10580085 -- 34,634,803(+) TGATA(-/TG)TGTGT nc-transcript-variant, upstream-variant-2KB, utr-variant-3-prime
rs10814128 -- 34,622,776(+) ATAAT(A/C)CAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID3C Gene

Variant ID Type Subtype PubMed ID
dgv12659n54 CNV loss 21841781
esv3620335 CNV gain 21293372
nsv1125318 OTHER inversion 24896259
nsv1161857 CNV deletion 26073780
nsv471997 CNV novel sequence insertion 20440878
nsv818699 CNV gain 17921354

Variation tolerance for ARID3C Gene

Residual Variation Intolerance Score: 62.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.75; 66.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARID3C Gene

Human Gene Mutation Database (HGMD)
ARID3C
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARID3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID3C Gene

Disorders for ARID3C Gene

Relevant External Links for ARID3C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARID3C

No disorders were found for ARID3C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARID3C Gene

Publications for ARID3C Gene

  1. Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription. (PMID: 21955986) Tidwell J.A. … Tucker P.W. (Mol. Immunol. 2011) 3 64
  2. REKLES is an ARID3-restricted multifunctional domain. (PMID: 17400556) Kim D. … Tucker P.W. (J. Biol. Chem. 2007) 4 64
  3. Nomenclature of the ARID family of DNA-binding proteins. (PMID: 15922553) Wilsker D. … Moran E. (Genomics 2005) 3 64
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
  5. ARID proteins: a diverse family of DNA binding proteins implicated in the control of cell growth, differentiation, and development. (PMID: 11959810) Wilsker D. … Moran E. (Cell Growth Differ. 2002) 3 64

Products for ARID3C Gene

Sources for ARID3C Gene

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