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Aliases for ARID3C Gene

Aliases for ARID3C Gene

  • AT Rich Interactive Domain 3C (BRIGHT-Like) 2 3
  • ARID Domain-Containing Protein 3C 3 4
  • AT-Rich Interactive Domain-Containing Protein 3C 3
  • AT Rich Interactive Domain 3C (BRIGHT- Like) 2
  • Brightlike 3

External Ids for ARID3C Gene

Previous GeneCards Identifiers for ARID3C Gene

  • GC09U900405
  • GC09M034612
  • GC09M034613
  • GC09M034575

Summaries for ARID3C Gene

Entrez Gene Summary for ARID3C Gene

  • This gene is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID3C Gene

ARID3C (AT Rich Interactive Domain 3C (BRIGHT-Like)) is a Protein Coding gene. GO annotations related to this gene include chromatin binding. An important paralog of this gene is ARID3B.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID3C Gene

Genomics for ARID3C Gene

Regulatory Elements for ARID3C Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARID3C Gene

Start:
34,621,379 bp from pter
End:
34,628,107 bp from pter
Size:
6,729 bases
Orientation:
Minus strand

Genomic View for ARID3C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARID3C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID3C Gene

Proteins for ARID3C Gene

  • Protein details for ARID3C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKF2-ARI3C_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 3C
    Protein Accession:
    A6NKF2
    Secondary Accessions:

    Protein attributes for ARID3C Gene

    Size:
    412 amino acids
    Molecular mass:
    44073 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARID3C Gene

Proteomics data for ARID3C Gene at MOPED

Post-translational modifications for ARID3C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARID3C Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for ARID3C Gene

Domains for ARID3C Gene

Protein Domains for ARID3C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARID3C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NKF2

UniProtKB/Swiss-Prot:

ARI3C_HUMAN :
  • A6NKF2
Domain:
  • Contains 1 ARID domain.
  • Contains 1 REKLES domain.
genes like me logo Genes that share domains with ARID3C: view

No data available for Gene Families for ARID3C Gene

Function for ARID3C Gene

Gene Ontology (GO) - Molecular Function for ARID3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ARID3C: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARID3C

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARID3C Gene

Localization for ARID3C Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID3C Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID3C Gene COMPARTMENTS Subcellular localization image for ARID3C gene
Compartment Confidence
nucleus 2
cytosol 1
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARID3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0045121 membrane raft IDA 21955986
genes like me logo Genes that share ontologies with ARID3C: view

Pathways for ARID3C Gene

SuperPathways for ARID3C Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARID3C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ARID3C: view

No data available for Pathways by source for ARID3C Gene

Transcripts for ARID3C Gene

mRNA/cDNA for ARID3C Gene

(4) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARID3C Gene

AT rich interactive domain 3C (BRIGHT-like):
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARID3C

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARID3C Gene

No ASD Table

Relevant External Links for ARID3C Gene

GeneLoc Exon Structure for
ARID3C
ECgene alternative splicing isoforms for
ARID3C

Expression for ARID3C Gene

mRNA expression in normal human tissues for ARID3C Gene

mRNA differential expression in normal tissues according to GTEx for ARID3C Gene

This gene is overexpressed in Liver (16.6).

Protein differential expression in normal tissues for ARID3C Gene

This gene is overexpressed in Skin (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ARID3C Gene

SOURCE GeneReport for Unigene cluster for ARID3C Gene Hs.534549

genes like me logo Genes that share expressions with ARID3C: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARID3C Gene

Orthologs for ARID3C Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID3C Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARID3C 35
  • 85.7 (n)
  • 85.78 (a)
ARID3C 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID3C 35
  • 87.12 (n)
  • 88.38 (a)
ARID3C 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arid3c 35
  • 82.32 (n)
  • 84.52 (a)
Arid3c 16
Arid3c 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARID3C 35
  • 99.57 (n)
  • 99.02 (a)
ARID3C 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arid3c 35
  • 83.21 (n)
  • 85.06 (a)
oppossum
(Monodelphis domestica)
Mammalia ARID3C 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARID3C 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARID3C 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARID3C 36
  • 51 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ARID3C 36
  • 34 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta retn 36
  • 19 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfi-1 36
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6971 36
  • 28 (a)
OneToMany
Species with no ortholog for ARID3C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARID3C Gene

ENSEMBL:
Gene Tree for ARID3C (if available)
TreeFam:
Gene Tree for ARID3C (if available)

Paralogs for ARID3C Gene

Paralogs for ARID3C Gene

Selected SIMAP similar genes for ARID3C Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARID3C: view

Variants for ARID3C Gene

Sequence variations from dbSNP and Humsavar for ARID3C Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs7018560 -- 34,623,448(+) GACTC(A/G)GCTGA missense, reference
rs7847086 -- 34,623,484(+) AGGTG(A/G)AACCC reference, missense
rs10122190 -- 34,626,109(+) CCCTC(C/T)GGGGC intron-variant
rs10814128 -- 34,622,776(+) ATAAT(A/C)CAGGT intron-variant
rs10814129 -- 34,623,721(+) TAGGG(A/G)CGGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID3C Gene

Variant ID Type Subtype PubMed ID
nsv893038 CNV Loss 21882294
nsv818699 CNV Gain 17921354
nsv893039 CNV Loss 21882294

Relevant External Links for ARID3C Gene

HapMap Linkage Disequilibrium report
ARID3C
Human Gene Mutation Database (HGMD)
ARID3C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID3C Gene

Disorders for ARID3C Gene

No disorders were found for ARID3C Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for ARID3C Gene

Publications for ARID3C Gene

  1. ARID proteins come in from the desert. (PMID: 10838570) Kortschak R.D. … Saint R. (Trends Biochem. Sci. 2000) 3
  2. ARID proteins: a diverse family of DNA binding proteins implicated in the control of cell growth, differentiation, and development. (PMID: 11959810) Wilsker D. … Moran E. (Cell Growth Differ. 2002) 3
  3. Nomenclature of the ARID family of DNA-binding proteins. (PMID: 15922553) Wilsker D. … Moran E. (Genomics 2005) 3
  4. Characterization of a new ARID family transcription factor (Brightlike/ARID3C) that co-activates Bright/ARID3A-mediated immunoglobulin gene transcription. (PMID: 21955986) Tidwell J.A. … Tucker P.W. (Mol. Immunol. 2011) 3
  5. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4

Products for ARID3C Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate ARID3C
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for ARID3C
    • Block miRNA regulation of ARID3C using miScript Target Protectors

    Sources for ARID3C Gene

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