Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARID3B Gene

Aliases for ARID3B Gene

  • AT Rich Interactive Domain 3B (BRIGHT-Like) 2 3
  • DRIL2 3 4 6
  • BDP 3 4 6
  • AT Rich Interactive Domain 3B (BRIGHT- Like) 2 3
  • ARID Domain-Containing Protein 3B 3 4
  • Bright And Dead Ringer Protein 3 4
  • Bright-Like Protein 3 4
  • AT-Rich Interactive Domain-Containing Protein 3B 3

External Ids for ARID3B Gene

Previous GeneCards Identifiers for ARID3B Gene

  • GC15P072549
  • GC15P072620
  • GC15P074833
  • GC15P051630

Summaries for ARID3B Gene

Entrez Gene Summary for ARID3B Gene

  • This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID3B Gene

ARID3B (AT Rich Interactive Domain 3B (BRIGHT-Like)) is a Protein Coding gene. Diseases associated with ARID3B include imperforate anus and intestinal atresia. An important paralog of this gene is ARID3A.

UniProtKB/Swiss-Prot for ARID3B Gene

  • Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.

Gene Wiki entry for ARID3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID3B Gene

Genomics for ARID3B Gene

Regulatory Elements for ARID3B Gene

Genomic Location for ARID3B Gene

Start:
74,541,177 bp from pter
End:
74,598,131 bp from pter
Size:
56,955 bases
Orientation:
Plus strand

Genomic View for ARID3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARID3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID3B Gene

Proteins for ARID3B Gene

  • Protein details for ARID3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVW6-ARI3B_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 3B
    Protein Accession:
    Q8IVW6
    Secondary Accessions:
    • O95443
    • Q59HC9
    • Q6P9C9

    Protein attributes for ARID3B Gene

    Size:
    561 amino acids
    Molecular mass:
    60637 Da
    Quaternary structure:
    • Heterodimer with ARID3A. Interacts with unphosphorylated RB1.
    SequenceCaution:
    • Sequence=BAD92067.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARID3B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARID3B Gene

Proteomics data for ARID3B Gene at MOPED

Post-translational modifications for ARID3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARID3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARID3B Gene

Domains for ARID3B Gene

Protein Domains for ARID3B Gene

Suggested Antigen Peptide Sequences for ARID3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IVW6

UniProtKB/Swiss-Prot:

ARI3B_HUMAN :
  • Q8IVW6
Domain:
  • Contains 1 ARID domain.
  • Contains 1 REKLES domain.
genes like me logo Genes that share domains with ARID3B: view

No data available for Gene Families for ARID3B Gene

Function for ARID3B Gene

Molecular function for ARID3B Gene

UniProtKB/Swiss-Prot Function: Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.

Gene Ontology (GO) - Molecular Function for ARID3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding IEA --
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0001205 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA --
GO:0003677 DNA binding NAS 10446990
genes like me logo Genes that share ontologies with ARID3B: view
genes like me logo Genes that share phenotypes with ARID3B: view

Animal Models for ARID3B Gene

MGI Knock Outs for ARID3B:

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARID3B Gene

Localization for ARID3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID3B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID3B Gene COMPARTMENTS Subcellular localization image for ARID3B gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for ARID3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus NAS 10446990
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with ARID3B: view

Pathways for ARID3B Gene

SuperPathways for ARID3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARID3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0008150 biological_process ND --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ARID3B: view

No data available for Pathways by source for ARID3B Gene

Transcripts for ARID3B Gene

Unigene Clusters for ARID3B Gene

AT rich interactive domain 3B (BRIGHT-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID3B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP1:
SP2:
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for ARID3B Gene

GeneLoc Exon Structure for
ARID3B
ECgene alternative splicing isoforms for
ARID3B

Expression for ARID3B Gene

mRNA expression in normal human tissues for ARID3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARID3B Gene

This gene is overexpressed in Whole Blood (8.4) and Testis (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARID3B Gene

SOURCE GeneReport for Unigene cluster for ARID3B Gene Hs.655532

mRNA Expression by UniProt/SwissProt for ARID3B Gene

Q8IVW6-ARI3B_HUMAN
Tissue specificity: Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K-562 erythrocytic leukemia cell line (at protein level).
genes like me logo Genes that share expressions with ARID3B: view

Orthologs for ARID3B Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID3B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARID3B 35
  • 99.51 (n)
  • 99.45 (a)
ARID3B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARID3B 35
  • 88.51 (n)
  • 88.89 (a)
ARID3B 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID3B 35
  • 90.37 (n)
  • 90.19 (a)
ARID3B 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arid3b 35
  • 87.54 (n)
  • 87.1 (a)
Arid3b 16
Arid3b 36
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARID3B 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARID3B 36
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arid3b 35
  • 86.7 (n)
  • 87.38 (a)
chicken
(Gallus gallus)
Aves ARID3B 35
  • 76.38 (n)
  • 74.48 (a)
ARID3B 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARID3B 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496484 35
  • 61.64 (n)
  • 61.22 (a)
zebrafish
(Danio rerio)
Actinopterygii arid3b 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta retn 36
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfi-1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6971 36
  • 34 (a)
OneToMany
Species with no ortholog for ARID3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARID3B Gene

ENSEMBL:
Gene Tree for ARID3B (if available)
TreeFam:
Gene Tree for ARID3B (if available)

Paralogs for ARID3B Gene

Paralogs for ARID3B Gene

Selected SIMAP similar genes for ARID3B Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for ARID3B Gene

genes like me logo Genes that share paralogs with ARID3B: view

Variants for ARID3B Gene

Sequence variations from dbSNP and Humsavar for ARID3B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1030888 -- 74,550,982(+) GGATT(C/G)GTTCC intron-variant
rs1044344 -- 74,596,173(+) CATGA(A/C)CCCAG utr-variant-3-prime
rs1821848 -- 74,541,443(-) CCGAC(C/T)CGCGC intron-variant
rs2028166 -- 74,559,166(-) GAGCC(A/G)AGTGC intron-variant
rs2415241 -- 74,566,421(-) GGTTT(C/T)ACCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID3B Gene

Variant ID Type Subtype PubMed ID
nsv1611 CNV Insertion 18451855
nsv513433 CNV Insertion 21212237
esv1046755 CNV Insertion 17803354
nsv904379 CNV Loss 21882294
nsv904380 CNV Loss 21882294
nsv457204 CNV Loss 19166990
nsv817698 CNV Gain 17921354

Relevant External Links for ARID3B Gene

HapMap Linkage Disequilibrium report
ARID3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID3B Gene

Disorders for ARID3B Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for ARID3B Gene including...

Search for ARID3B Gene in MalaCards »

(2) University of Copenhagen DISEASES for ARID3B Gene

Relevant External Links for ARID3B

Genetic Association Database (GAD)
ARID3B
Human Genome Epidemiology (HuGE) Navigator
ARID3B
genes like me logo Genes that share disorders with ARID3B: view

No data available for UniProtKB/Swiss-Prot for ARID3B Gene

Publications for ARID3B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product. (PMID: 10446990) Numata S. … Croce C.M. (Cancer Res. 1999) 3 4
  3. Genome-wide association study identifies eight loci associated with blood pressure. (PMID: 19430483) Newton-Cheh C. … Munroe P.B. (Nat. Genet. 2009) 3 48
  4. The epidermal growth factor receptor responsive miR-125a represses mesenchymal morphology in ovarian cancer cells. (PMID: 19881956) Cowden Dahl K.D. … Hudson L.G. (Neoplasia 2009) 3
  5. An atlas of combinatorial transcriptional regulation in mouse and man. (PMID: 20211142) Ravasi T. … Hayashizaki Y. (Cell 2010) 3

Products for ARID3B Gene

Sources for ARID3B Gene

Back to Top

Content