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Aliases for ARID3B Gene

Aliases for ARID3B Gene

  • AT-Rich Interaction Domain 3B 2 3 5
  • AT Rich Interactive Domain 3B (BRIGHT- Like) 2 3
  • AT Rich Interactive Domain 3B (BRIGHT-Like) 2 3
  • ARID Domain-Containing Protein 3B 3 4
  • Bright And Dead Ringer Protein 3 4
  • Bright-Like Protein 3 4
  • DRIL2 3 4
  • BDP 3 4

External Ids for ARID3B Gene

Previous GeneCards Identifiers for ARID3B Gene

  • GC15P072549
  • GC15P072620
  • GC15P074833
  • GC15P051630

Summaries for ARID3B Gene

Entrez Gene Summary for ARID3B Gene

  • This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID3B Gene

ARID3B (AT-Rich Interaction Domain 3B) is a Protein Coding gene. Diseases associated with ARID3B include Neuroblastoma and Chromosome 15Q24 Deletion Syndrome. GO annotations related to this gene include RNA polymerase II core promoter proximal region sequence-specific DNA binding and RNA polymerase II distal enhancer sequence-specific DNA binding. An important paralog of this gene is ARID1A.

UniProtKB/Swiss-Prot for ARID3B Gene

  • Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.

Gene Wiki entry for ARID3B Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID3B Gene

Genomics for ARID3B Gene

Regulatory Elements for ARID3B Gene

Enhancers for ARID3B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARID3B on UCSC Golden Path with GeneCards custom track

Promoters for ARID3B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARID3B on UCSC Golden Path with GeneCards custom track

Genomic Location for ARID3B Gene

74,541,177 bp from pter
74,598,131 bp from pter
56,955 bases
Plus strand

Genomic View for ARID3B Gene

Genes around ARID3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARID3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARID3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID3B Gene

Proteins for ARID3B Gene

  • Protein details for ARID3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    AT-rich interactive domain-containing protein 3B
    Protein Accession:
    Secondary Accessions:
    • O95443
    • Q59HC9
    • Q6P9C9

    Protein attributes for ARID3B Gene

    561 amino acids
    Molecular mass:
    60637 Da
    Quaternary structure:
    • Heterodimer with ARID3A. Interacts with unphosphorylated RB1.
    • Sequence=BAD92067.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARID3B Gene


neXtProt entry for ARID3B Gene

Proteomics data for ARID3B Gene at MOPED

Post-translational modifications for ARID3B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARID3B Gene

No data available for DME Specific Peptides for ARID3B Gene

Domains & Families for ARID3B Gene

Gene Families for ARID3B Gene

Protein Domains for ARID3B Gene

Suggested Antigen Peptide Sequences for ARID3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 ARID domain.
  • Contains 1 ARID domain.
  • Contains 1 REKLES domain.
genes like me logo Genes that share domains with ARID3B: view

Function for ARID3B Gene

Molecular function for ARID3B Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which may be involved in neuroblastoma growth and malignant transformation. Favors nuclear targeting of ARID3A.

Gene Ontology (GO) - Molecular Function for ARID3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IEA --
GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding IEA --
GO:0003677 DNA binding IEA,NAS 10446990
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with ARID3B: view
genes like me logo Genes that share phenotypes with ARID3B: view

Animal Models for ARID3B Gene

MGI Knock Outs for ARID3B:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARID3B Gene

Localization for ARID3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID3B Gene

Subcellular locations from

Jensen Localization Image for ARID3B Gene COMPARTMENTS Subcellular localization image for ARID3B gene
Compartment Confidence
nucleus 5

No data available for Gene Ontology (GO) - Cellular Components for ARID3B Gene

Pathways & Interactions for ARID3B Gene

SuperPathways for ARID3B Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARID3B Gene


No data available for Pathways by source and SIGNOR curated interactions for ARID3B Gene

Drugs & Compounds for ARID3B Gene

No Compound Related Data Available

Transcripts for ARID3B Gene

Unigene Clusters for ARID3B Gene

AT rich interactive domain 3B (BRIGHT-like):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARID3B Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12
SP3: - -

Relevant External Links for ARID3B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARID3B Gene

mRNA expression in normal human tissues for ARID3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARID3B Gene

This gene is overexpressed in Whole Blood (x8.4) and Testis (x4.7).

Protein differential expression in normal tissues from HIPED for ARID3B Gene

This gene is overexpressed in Placenta (40.6), Testis (10.8), CD8 Tcells (6.8), and Retina (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARID3B Gene

SOURCE GeneReport for Unigene cluster for ARID3B Gene Hs.655532

mRNA Expression by UniProt/SwissProt for ARID3B Gene

Tissue specificity: Expressed in placenta, testis and leukocytes. Expressed in neuroblastoma. Present in K-562 erythrocytic leukemia cell line (at protein level).
genes like me logo Genes that share expression patterns with ARID3B: view

Protein tissue co-expression partners for ARID3B Gene

- Elite partner

Primer Products

Orthologs for ARID3B Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID3B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARID3B 35
  • 88.51 (n)
  • 88.89 (a)
  • 89 (a)
(Canis familiaris)
Mammalia ARID3B 35
  • 90.37 (n)
  • 90.19 (a)
  • 89 (a)
(Mus musculus)
Mammalia Arid3b 35
  • 87.54 (n)
  • 87.1 (a)
Arid3b 16
Arid3b 36
  • 85 (a)
(Pan troglodytes)
Mammalia ARID3B 35
  • 99.51 (n)
  • 99.45 (a)
  • 100 (a)
(Rattus norvegicus)
Mammalia Arid3b 35
  • 86.7 (n)
  • 87.38 (a)
(Monodelphis domestica)
Mammalia ARID3B 36
  • 71 (a)
(Ornithorhynchus anatinus)
Mammalia ARID3B 36
  • 83 (a)
(Gallus gallus)
Aves ARID3B 35
  • 76.38 (n)
  • 74.48 (a)
  • 62 (a)
(Anolis carolinensis)
Reptilia ARID3B 36
  • 71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496484 35
  • 61.64 (n)
  • 61.22 (a)
(Danio rerio)
Actinopterygii arid3b 36
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta retn 36
  • 20 (a)
(Caenorhabditis elegans)
Secernentea cfi-1 36
  • 34 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6971 36
  • 34 (a)
Species with no ortholog for ARID3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARID3B Gene

Gene Tree for ARID3B (if available)
Gene Tree for ARID3B (if available)

Paralogs for ARID3B Gene

Paralogs for ARID3B Gene

(2) SIMAP similar genes for ARID3B Gene using alignment to 2 proteins: Pseudogenes for ARID3B Gene

genes like me logo Genes that share paralogs with ARID3B: view

Variants for ARID3B Gene

Sequence variations from dbSNP and Humsavar for ARID3B Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs6495112 -- 74,540,457(+) TGTTG(A/C)ATGGG upstream-variant-2KB
rs6495113 -- 74,552,335(+) ggatt(A/G)caggc intron-variant
rs6495114 -- 74,569,392(+) GACCA(A/G)CCTGG intron-variant
rs6495115 -- 74,578,122(+) aaagt(A/G)ctgga intron-variant
rs6495116 -- 74,593,607(+) ACCCC(A/G)GTATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID3B Gene

Variant ID Type Subtype PubMed ID
nsv1611 CNV Insertion 18451855
nsv513433 CNV Insertion 21212237
esv1046755 CNV Insertion 17803354
nsv904379 CNV Loss 21882294
nsv904380 CNV Loss 21882294
nsv457204 CNV Loss 19166990
nsv817698 CNV Gain 17921354

Variation tolerance for ARID3B Gene

Residual Variation Intolerance Score: 78.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.78; 47.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARID3B Gene

Disorders for ARID3B Gene

MalaCards: The human disease database

(2) MalaCards diseases for ARID3B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • neuroblastoma 1
chromosome 15q24 deletion syndrome
  • 15q24 microdeletion syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARID3B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARID3B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARID3B Gene

Publications for ARID3B Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Critical role of ARID3B in the expression of pro-apoptotic p53-target genes and apoptosis. (PMID: 26519881) Pratama E. … Ikeda M.A. (Biochem. Biophys. Res. Commun. 2015) 3
  5. Differential expression of ARID3B in normal adult tissue and carcinomas. (PMID: 24704276) Samyesudhas S.J. … Cowden Dahl K.D. (Gene 2014) 3

Products for ARID3B Gene

Sources for ARID3B Gene