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Aliases for ARID3A Gene

Aliases for ARID3A Gene

  • AT-Rich Interaction Domain 3A 2 3 5
  • AT Rich Interactive Domain 3A (BRIGHT-Like) 2 3
  • B-Cell Regulator Of IgH Transcription 3 4
  • ARID Domain-Containing Protein 3A 3 4
  • Dead Ringer-Like Protein 1 3 4
  • E2F-Binding Protein 1 3 4
  • BRIGHT 3 4
  • E2FBP1 3 4
  • DRIL1 3 4
  • DRIL3 3 4
  • AT Rich Interactive Domain 3A (BRIGHT- Like) Protein 3
  • AT-Rich Interactive Domain-Containing Protein 3A 3
  • AT Rich Interactive Domain 3A (BRIGHT- Like) 2
  • Dead Ringer-Like 1 (Drosophila) 2
  • ARID Domain-Containing 3A 3
  • Dead Ringer-Like 1 3
  • DRX 4

External Ids for ARID3A Gene

Previous HGNC Symbols for ARID3A Gene

  • DRIL1

Previous GeneCards Identifiers for ARID3A Gene

  • GC19P000880
  • GC19P000877
  • GC19P000699

Summaries for ARID3A Gene

Entrez Gene Summary for ARID3A Gene

  • This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA binding proteins. It was found by homology to the Drosophila dead ringer gene, which is important for normal embryogenesis. Other ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation, and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARID3A Gene

ARID3A (AT-Rich Interaction Domain 3A) is a Protein Coding gene. Among its related pathways are TP53 Regulates Transcription of Cell Cycle Genes and Regulation of TP53 Activity. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and chromatin binding. An important paralog of this gene is ARID3B.

UniProtKB/Swiss-Prot for ARID3A Gene

  • Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.

Gene Wiki entry for ARID3A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARID3A Gene

Genomics for ARID3A Gene

Regulatory Elements for ARID3A Gene

Enhancers for ARID3A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around ARID3A on UCSC Golden Path with GeneCards custom track

Promoters for ARID3A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ARID3A Gene

Chromosome:
19
Start:
925,781 bp from pter
End:
975,934 bp from pter
Size:
50,154 bases
Orientation:
Plus strand

Genomic View for ARID3A Gene

Genes around ARID3A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARID3A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARID3A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARID3A Gene

Proteins for ARID3A Gene

  • Protein details for ARID3A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99856-ARI3A_HUMAN
    Recommended name:
    AT-rich interactive domain-containing protein 3A
    Protein Accession:
    Q99856
    Secondary Accessions:
    • Q5I858
    • Q6P9C6
    • Q8IZA7
    • Q8N4Z3

    Protein attributes for ARID3A Gene

    Size:
    593 amino acids
    Molecular mass:
    62889 Da
    Quaternary structure:
    • Homodimer. Heterodimer with ARID3B. Interacts with E2F1. Interacts with GTF2I and BTK.
    SequenceCaution:
    • Sequence=AAW30734.1; Type=Frameshift; Positions=498; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARID3A Gene

neXtProt entry for ARID3A Gene

Post-translational modifications for ARID3A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARID3A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARID3A Gene

Domains & Families for ARID3A Gene

Gene Families for ARID3A Gene

Protein Domains for ARID3A Gene

Suggested Antigen Peptide Sequences for ARID3A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99856

UniProtKB/Swiss-Prot:

ARI3A_HUMAN :
  • Contains 1 ARID domain.
Domain:
  • Contains 1 ARID domain.
  • Contains 1 REKLES domain.
genes like me logo Genes that share domains with ARID3A: view

Function for ARID3A Gene

Molecular function for ARID3A Gene

UniProtKB/Swiss-Prot Function:
Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
UniProtKB/Swiss-Prot Induction:
By p53/TP53 following DNA damage.

Gene Ontology (GO) - Molecular Function for ARID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA --
GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding IEA,IBA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IEA --
GO:0003700 transcription factor activity, sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with ARID3A: view
genes like me logo Genes that share phenotypes with ARID3A: view

Animal Models for ARID3A Gene

MGI Knock Outs for ARID3A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARID3A Gene

Localization for ARID3A Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARID3A Gene

Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARID3A Gene COMPARTMENTS Subcellular localization image for ARID3A gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for ARID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA,IBA --
GO:0005654 nucleoplasm TAS --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with ARID3A: view

Pathways & Interactions for ARID3A Gene

genes like me logo Genes that share pathways with ARID3A: view

Gene Ontology (GO) - Biological Process for ARID3A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription from RNA polymerase II promoter IEA --
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest TAS --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IEA --
genes like me logo Genes that share ontologies with ARID3A: view

No data available for SIGNOR curated interactions for ARID3A Gene

Drugs & Compounds for ARID3A Gene

No Compound Related Data Available

Transcripts for ARID3A Gene

Unigene Clusters for ARID3A Gene

AT rich interactive domain 3A (BRIGHT-like):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARID3A Gene

No ASD Table

Relevant External Links for ARID3A Gene

GeneLoc Exon Structure for
ARID3A
ECgene alternative splicing isoforms for
ARID3A

Expression for ARID3A Gene

mRNA expression in normal human tissues for ARID3A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARID3A Gene

This gene is overexpressed in Whole Blood (x9.8).

Protein differential expression in normal tissues from HIPED for ARID3A Gene

This gene is overexpressed in Fetal gut (28.0), Placenta (19.2), and Monocytes (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARID3A Gene



NURSA nuclear receptor signaling pathways regulating expression of ARID3A Gene:

ARID3A

SOURCE GeneReport for Unigene cluster for ARID3A Gene:

Hs.501296

mRNA Expression by UniProt/SwissProt for ARID3A Gene:

Q99856-ARI3A_HUMAN
Tissue specificity: Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.
genes like me logo Genes that share expression patterns with ARID3A: view

Primer Products

No data available for Protein tissue co-expression partners for ARID3A Gene

Orthologs for ARID3A Gene

This gene was present in the common ancestor of animals.

Orthologs for ARID3A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARID3A 34
  • 81.7 (n)
  • 82.68 (a)
ARID3A 35
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARID3A 34
  • 84.58 (n)
  • 84.98 (a)
ARID3A 35
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arid3a 34
  • 78.89 (n)
  • 81.49 (a)
Arid3a 16
Arid3a 35
  • 80 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arid3a 34
  • 78.16 (n)
  • 81.3 (a)
oppossum
(Monodelphis domestica)
Mammalia ARID3A 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARID3A 35
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARID3A 35
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARID3A 34
  • 73.54 (n)
  • 69.41 (a)
ARID3A 35
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arid3a 34
  • 68.3 (n)
  • 71.89 (a)
Str.11240 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.26694 34
zebrafish
(Danio rerio)
Actinopterygii LOC562799 34
  • 71 (n)
  • 74.28 (a)
ARID3A 35
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta retn 35
  • 20 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea cfi-1 35
  • 35 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6971 35
  • 38 (a)
OneToMany
Species where no ortholog for ARID3A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARID3A Gene

ENSEMBL:
Gene Tree for ARID3A (if available)
TreeFam:
Gene Tree for ARID3A (if available)

Paralogs for ARID3A Gene

Paralogs for ARID3A Gene

(3) SIMAP similar genes for ARID3A Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARID3A: view

Variants for ARID3A Gene

Sequence variations from dbSNP and Humsavar for ARID3A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs17857499 - 929,635(+) ACCCC(A/C/G)CGGCC reference, missense
rs17857501 - 964,840(+) ACATG(A/G)AGTAC reference, missense
rs1051505 - 971,949(+) gcggc(A/G)gcagc reference, missense
rs3216345 -- 931,409(+) TCGTG(-/CC)CCTTT intron-variant
rs3216346 -- 950,829(+) TTTTT(-/T)GAGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARID3A Gene

Variant ID Type Subtype PubMed ID
dgv134n111 CNV deletion 26073780
esv1501734 CNV deletion 17803354
esv2665746 CNV deletion 23128226
esv2673891 CNV deletion 23128226
esv2717811 CNV deletion 23290073
esv2717812 CNV deletion 23290073
esv2717813 CNV deletion 23290073
esv2758743 CNV gain+loss 17122850
esv3453 CNV loss 18987735
esv3643377 CNV loss 21293372
esv3643378 CNV loss 21293372
esv3643379 CNV gain 21293372
nsv1072834 CNV deletion 25765185
nsv1072835 CNV deletion 25765185
nsv1127642 CNV deletion 24896259
nsv1160555 CNV deletion 26073780
nsv469845 CNV loss 16826518
nsv470101 CNV loss 18288195
nsv578188 CNV loss 21841781
nsv833704 CNV gain 17160897
nsv953938 CNV deletion 24416366
nsv9662 CNV gain 18304495

Variation tolerance for ARID3A Gene

Residual Variation Intolerance Score: 29.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARID3A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARID3A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARID3A Gene

Disorders for ARID3A Gene

Relevant External Links for ARID3A

Genetic Association Database (GAD)
ARID3A
Human Genome Epidemiology (HuGE) Navigator
ARID3A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARID3A

No disorders were found for ARID3A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARID3A Gene

Publications for ARID3A Gene

  1. The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome. (PMID: 9722953) Kortschak R.D. … Jenne D.E. (Genomics 1998) 2 3 4 65
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 65
  3. Solution NMR structure of the ARID domain of human AT-rich interactive domain-containing protein 3A: a human cancer protein interaction network target. (PMID: 20455271) Liu G. … Montelione G.T. (Proteins 2010) 3 4 65
  4. A genome-wide association study of optic disc parameters. (PMID: 20548946) Ramdas W.D. … van Duijn C.M. (PLoS Genet. 2010) 3 46 65
  5. Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I. (PMID: 16738337) Rajaiya J. … Webb C.F. (Mol. Cell. Biol. 2006) 3 4 65

Products for ARID3A Gene

Sources for ARID3A Gene

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