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Aliases & Descriptions for RHOH
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| ARHH 2, 3 | | RhoH 1 | | TTF 1, 2, 3 |
| | | Descriptions |
|---|
| GTP-binding protein TTF 3 | | TTF, translocation three four 2 | | ras homolog gene family, member H 2 | | rho-related GTP-binding protein 2 |
|
| | Search outside databases for aliases for RHOH genePrevious GC identifers: GC04P040096 GC04P040021 |
Summaries for RHOH(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for RHOH: The protein encoded by this gene is a member of the Ras superfamily of small GTPases. Expression of a chimeric transcript of LAZ3 and this gene has been reported as a result of the translocation t(3;4) in non-Hodgkin's lymphomas. This gene encodes a small G-like protein, and unlike most other small G proteins which are expressed ubiquitously, this gene is transcribed only in hemopoietic cells. [provided by RefSeq] Gene Wiki entry for RHOH (RhoH) |
Genomic Location for RHOH
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the RHOH gene 
Entrez Gene cytogenetic band: 4p13 Ensembl cytogenetic band: 4p14 HGNC cytogenetic band: 4p13RHOH Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P039875:
(about GC identifiers)
Start:
|
39,874,922 bp from pter |
End:
|
39,922,676 bp from pter |
Size:
|
47,755 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_016297.15
| Proteins for RHOH
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669 (See
protein sequence)Recommended Name: Rho-related GTP-binding protein RhoH precursor Size: 191 amino acids; 21331 Da
Subcellular location: Cell membrane; Lipid-anchor; Cytoplasmic side (Potential)REFSEQ proteins: NP_004301.1
ENSEMBL proteins: ENSP00000371219
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: RHOH 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for RHOH: Assays for RHOH: | Protein
Domains/ Families for RHOH(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q15669
ProtoNet protein and cluster: Q15669 2 Blocks protein families: IPB001806 Transforming protein P21 RAS signature IPB003578 Ras small GTPase
UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669Similarity: Belongs to the small GTPase superfamily. Rho family | Gene Function for RHOH
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004310
Applied Biosystems Silencer® siRNAs for RHOH
Sigma-Aldrich siRNA for RHOH  Sigma-Aldrich shRNA Panels and shRNA for RHOH  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004310                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004310                                  untagged cDNA clone in CMV expression vector: NM_004310 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004310
2 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Rhoh):
5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6
): About this table | Pathways & Interactions for RHOH
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 5/12 Sigma-Aldrich "Your Favorite Gene" Pathways for RHOH (Your Favorite Gene powered by Ingenuity) (see all 12
) 
5/136 Interacting proteins for RHOH (ENSP000003712193 Q156691, 2) via UniProtKB, MINT, and/or STRING (see all 136
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for RHOH(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  |
Enzo Life Sciences drugs & compounds for RHOH |
Browse Tocris compounds for RHOH 7 Novoseek chemical compound relationships for RHOH gene
About this table
|
Transcripts for RHOH(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004310
Sigma-Aldrich siRNA for RHOH  Sigma-Aldrich shRNA Panels and shRNA for RHOH  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004310 REFSEQ mRNAs for RHOH gene: NM_004310.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004310               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004310                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004310                                  untagged cDNA clone in CMV expression vector: NM_004310  Additional cDNA sequence: AF498975.1 AK097117.1 AK313744.1 AY673952.1 AY673953.1 AY673954.1 AY673956.1 BC014261.2 CR450349.1 CR607001.1 CR619539.1 Z35227.1 17 DOTS entries: DT.310854 DT.121223917 DT.95163415 DT.121223953 DT.75123900 DT.95073024 DT.99983020 DT.92012292 DT.92064734 DT.121223958 DT.100695373 DT.100857545 DT.121223909 DT.121223937 DT.121223970 DT.433771 DT.95163414 24/104 AceView cDNA sequences (see all 104
):BX447460 AY673954 NM_004310 AY673955 AF498975 BC014261 BX421813 AY673953 AY673956 AL532319 BP338424 BX404688 CR450349 CR619539 CR607001 CD367697 BP367186 BU626663 CD367666 BX415177 BF366563 BE677591 BG257364 CD639044
highest scoring ESTs for RHOH:Z35227 AA357186 AA573419 AA767445 AA824491 AF498975 AI371502 AI440064 AI471495 AI475705 Unigene Cluster for RHOH: Ras homolog gene family, member H Hs.654594 [show with all ESTs]Unigene Representative Sequence: AK097117
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for RHOH (see all 13
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10a | · | 10b | · | 10c | · | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | |   | |   | - |   | - |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | |   | |   | - |   | - |   | - |   | - |   | - |   | - |   | |   | |   | - |   | - |   | |   | |   | |   |
| ExUns: | 10d | · | 10e | · | 10f | · | 10g | |
| SP1: | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for RHOH
1 Ensembl transcript including schematic representation: ENST00000381799
|
Expression for RHOH
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| RHOH expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for RHOH
1 / 2 / 3 3 probe-sets matching RHOH gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAAGGGAAGA
SOURCE GeneReport for Unigene cluster: Hs.654594
Expression variation in blood from EXPOLDB for RHOH UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669Tissue specificity: Transcribed only in hemopoietic cells |
Orthologs for RHOH
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for RHOH gene from 5/8 species (see all 8
)
About this table Species with no ortholog for RHOH
ENSEMBL Gene Tree for RHOH | Paralogs for RHOH(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for RHOH gene
- RHOD2 RHOF2
|
SNPs/Variants for RHOH(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for RHOH (up to first 250kb)
|
Disorders & Mutations for RHOH
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602037
UniProtKB/Swiss-Prot: RHOH_HUMAN, Q15669
A chromosomal aberration involving RHOH is found in a non-Hodgkin lymphoma cell line. Translocation t(3;4)(q27;p11) with BCL61 Novoseek disease relationship for RHOH gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0.00 |
1 |
9478968 (1) |
About this table
|
Medical News for RHOH(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for RHOH (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/78 PubMed articles for RHOH gene (see all 78
):- TTF, a gene encoding a novel small G protein, fuses to the lymphoma- associated LAZ3 gene by t(3;4) chromosomal translocation. (PubMed id 7784061)1, 2, 3, 4 Dallery E.... Kerckaert J.-P. (1995)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Structural features of hematopoiesis-specific RhoH/ARHH gene: high diversity of 5'-UTR in different hematopoietic lineages suggests a complex post-transcriptional regulation. (PubMed id 15563831)1, 3 Lahousse S....Galiegue-Zouitina S. (2004)
- Genomic structure and assignment of the RhoH/TTF small GTPase gene (ARHH) to 4p13 by in situ hybridization. (PubMed id 9226377)1, 3 Dallery-Prudhomme E....Galiegue-Zouitina S. (1997)
- Underexpression of RhoH in Hairy Cell Leukemia. (PubMed id 18559497)3 Galiegue-Zouitina S....Shelley C.S. (2008)
- Prognostic implication and biological roles of RhoH in acute myeloid leukaemia. (PubMed id 18691253)3 Iwasaki T....Naoe T. (2008)
- Prognostic analysis of aberrant somatic hypermutation of RhoH gene in diffuse large B cell lymphoma. (PubMed id 17443219)3 Hiraga J....Naoe T. (2007)
- Analysis of BCL-6, CD95, PIM1, RHO/TTF and PAX5 mutations in splenic and nodal marginal zone B-cell lymphomas suggests a particular B-cell origin. (PubMed id 17476282)3 Traverse-Glehen A....Salles G. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)3 Kimura K.... Sugano S. (2006)
- Richter's and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation-induced cytidine deaminase and aberrant somatic hypermutation. (PubMed id 16541139)3 Reiniger L....Matolcsy A. (2006)
|
Search for RHOH
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing RHOH
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing RHOH
(According to HUGE)
About This Section
| -- |
Specialized Databases showing RHOH(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for RHOH(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for RHOH:

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| | Recombinant Proteins (RHOH) | | Antibodies (RHOH) |
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Incremental update: 13 Oct 2009
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