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Aliases for ARHGEF7 Gene

Aliases for ARHGEF7 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 7 2 3
  • PAK-Interacting Exchange Factor Beta 2 3 4
  • COOL1 3 4 6
  • PIXB 3 4 6
  • SH3 Domain-Containing Proline-Rich Protein 2 3
  • Guanine Nucleotide Exchange Factor 7 2 3
  • BETA-PIX 3 4
  • COOL-1 3 4
  • P85SPR 3 4
  • P85 3 4
  • Rho Guanine Nucleotide Exchange Factor 7 3
  • Nbla10314 3
  • P85COOL1 3
  • KIAA0142 4
  • PAK3BP 4
  • P50BP 3
  • PAK3 3
  • Rho 2
  • P50 3

External Ids for ARHGEF7 Gene

Previous GeneCards Identifiers for ARHGEF7 Gene

  • GC13P110166
  • GC13P106154
  • GC13P110604
  • GC13P109465
  • GC13P110565
  • GC13P111766
  • GC13P092335

Summaries for ARHGEF7 Gene

Entrez Gene Summary for ARHGEF7 Gene

  • Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF7 Gene

ARHGEF7 (Rho Guanine Nucleotide Exchange Factor (GEF) 7) is a Protein Coding gene. Diseases associated with ARHGEF7 include borjeson-forssman-lehmann syndrome. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include phospholipid binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF6.

UniProtKB/Swiss-Prot for ARHGEF7 Gene

  • Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

Gene Wiki entry for ARHGEF7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF7 Gene

Genomics for ARHGEF7 Gene

Regulatory Elements for ARHGEF7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARHGEF7 Gene

Start:
111,114,559 bp from pter
End:
111,305,737 bp from pter
Size:
191,179 bases
Orientation:
Plus strand

Genomic View for ARHGEF7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF7 Gene

Proteins for ARHGEF7 Gene

  • Protein details for ARHGEF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14155-ARHG7_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 7
    Protein Accession:
    Q14155
    Secondary Accessions:
    • B1ALK6
    • B1ALK8
    • Q3LIA4
    • Q5W9H0
    • Q6P9G3
    • Q6PII2
    • Q86W63
    • Q8N3M1

    Protein attributes for ARHGEF7 Gene

    Size:
    803 amino acids
    Molecular mass:
    90012 Da
    Quaternary structure:
    • Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1 and RAC1. Interacts with ITCH and PARVB (By similarity). Interacts with unphosphorylated PAK1. Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis. Interacts with FRMPD4 (via N-terminus). Interacts with CaMK1. Interacts with BIN2. Isoform 1 and isoform 5 interact with SNX27.
    SequenceCaution:
    • Sequence=AAH50521.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAA09763.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAD38906.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGEF7 Gene

    Alternative splice isoforms for ARHGEF7 Gene

neXtProt entry for ARHGEF7 Gene

Proteomics data for ARHGEF7 Gene at MOPED

Post-translational modifications for ARHGEF7 Gene

  • Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1; enhancement of GEF activity and downstream activation of RAC1.
  • Ubiquitination at Lys524, Lys547, and Lys598
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ARHGEF7 (ARHGEF7)

No data available for DME Specific Peptides for ARHGEF7 Gene

Domains for ARHGEF7 Gene

Gene Families for ARHGEF7 Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors
  • PLEKH :Pleckstrin homology (PH) domain containing

Graphical View of Domain Structure for InterPro Entry

Q14155

UniProtKB/Swiss-Prot:

ARHG7_HUMAN :
  • Q14155
Domain:
  • Contains 1 CH (calponin-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGEF7: view

Function for ARHGEF7 Gene

Molecular function for ARHGEF7 Gene

UniProtKB/Swiss-Prot Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes the formation of spines and synapses in hippocampal neurons.

Gene Ontology (GO) - Molecular Function for ARHGEF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IDA 21048939
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 11864573
GO:0019901 protein kinase binding IPI 21048939
genes like me logo Genes that share ontologies with ARHGEF7: view

Phenotypes for ARHGEF7 Gene

GenomeRNAi human phenotypes for ARHGEF7:
genes like me logo Genes that share phenotypes with ARHGEF7: view

Animal Model Products

CRISPR Products

miRNA for ARHGEF7 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGEF7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGEF7 Gene

Localization for ARHGEF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF7 Gene

Cell junction, focal adhesion. Cell projection, ruffle. Cytoplasm, cell cortex. Cell projection, lamellipodium. Note=Detected at cell adhesions. A small proportion is detected at focal adhesions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF7 Gene COMPARTMENTS Subcellular localization image for ARHGEF7 gene
Compartment Confidence
cytosol 4
nucleus 3
cytoskeleton 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARHGEF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005829 cytosol TAS --
GO:0005925 focal adhesion IDA 21423176
GO:0005938 cell cortex IEA --
GO:0030027 lamellipodium ISS --
genes like me logo Genes that share ontologies with ARHGEF7: view

Pathways for ARHGEF7 Gene

genes like me logo Genes that share pathways with ARHGEF7: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for ARHGEF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0007165 signal transduction TAS 9659915
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007399 nervous system development --
genes like me logo Genes that share ontologies with ARHGEF7: view

Compounds for ARHGEF7 Gene

(3) HMDB Compounds for ARHGEF7 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1

(11) Novoseek inferred chemical compound relationships for ARHGEF7 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 76.8 32
tyrosine 59.2 23
phosphotyrosine 55 2
wortmannin 54.7 1
phosphoinositide 49.6 2
genes like me logo Genes that share compounds with ARHGEF7: view

Transcripts for ARHGEF7 Gene

Unigene Clusters for ARHGEF7 Gene

Rho guanine nucleotide exchange factor (GEF) 7:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGEF7

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARHGEF7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF7 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
SP1: - - - - - - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - -
SP7:
SP8:
SP9:
SP10: - - -
SP11:
SP12: - - -
SP13:

ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
SP1: - - -
SP2: - - - -
SP3: - - - -
SP4: - - -
SP5: - - -
SP6: - - - -
SP7: -
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:

Relevant External Links for ARHGEF7 Gene

GeneLoc Exon Structure for
ARHGEF7
ECgene alternative splicing isoforms for
ARHGEF7

Expression for ARHGEF7 Gene

mRNA expression in normal human tissues for ARHGEF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGEF7 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF7 Gene Hs.508738

genes like me logo Genes that share expressions with ARHGEF7: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for ARHGEF7 Gene

Orthologs for ARHGEF7 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF7 35
  • 99.52 (n)
  • 99.68 (a)
ARHGEF7 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGEF7 35
  • 88.36 (n)
  • 94.88 (a)
ARHGEF7 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF7 35
  • 90 (n)
  • 95.2 (a)
ARHGEF7 36
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef7 35
  • 87.13 (n)
  • 94.5 (a)
Arhgef7 16
Arhgef7 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF7 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF7 36
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef7 35
  • 86.43 (n)
  • 93.97 (a)
chicken
(Gallus gallus)
Aves ARHGEF7 35
  • 83.35 (n)
  • 93.64 (a)
ARHGEF7 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF7 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef7 35
  • 77.22 (n)
  • 87.34 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgef7a 35
  • 71.28 (n)
  • 77.42 (a)
arhgef7a 36
  • 69 (a)
OneToMany
arhgef7b 36
  • 65 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta rtGEF 36
  • 16 (a)
OneToMany
rtGEF 37
  • 45 (a)
worm
(Caenorhabditis elegans)
Secernentea pix-1 35
  • 44.36 (n)
  • 31.48 (a)
pix-1 36
  • 24 (a)
OneToMany
K11E4.4 37
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2909 36
  • 41 (a)
OneToMany
Species with no ortholog for ARHGEF7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF7 Gene

ENSEMBL:
Gene Tree for ARHGEF7 (if available)
TreeFam:
Gene Tree for ARHGEF7 (if available)

Paralogs for ARHGEF7 Gene

genes like me logo Genes that share paralogs with ARHGEF7: view

Variants for ARHGEF7 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF7 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs2951 -- 111,280,943(-) CCACA(C/T)GGAGC intron-variant
rs6692 -- 111,305,522(+) CATGC(A/G)CTGGG utr-variant-3-prime
rs748421 -- 111,122,942(-) ctCCC(A/C)GCACA intron-variant
rs755029 -- 111,199,154(+) CTGCC(C/T)CTGCC intron-variant
rs831140 -- 111,114,877(-) GCTTT(A/G)CTACC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF7 Gene

Variant ID Type Subtype PubMed ID
dgv594e1 CNV Complex 17122850
esv2751129 CNV Gain 17911159
nsv1185 CNV Loss 18451855
nsv901015 CNV Loss 21882294
esv32604 CNV Loss 17666407
nsv1186 CNV Loss 18451855
esv2748050 CNV Deletion 23290073
dgv268e201 CNV Deletion 23290073
dgv269e201 CNV Deletion 23290073
esv1576482 CNV Deletion 17803354
esv2748053 CNV Deletion 23290073
esv2748054 CNV Deletion 23290073
esv2748055 CNV Deletion 23290073
esv2748056 CNV Deletion 23290073
esv2748057 CNV Deletion 23290073
esv2748058 CNV Deletion 23290073
esv2748059 CNV Deletion 23290073

Relevant External Links for ARHGEF7 Gene

HapMap Linkage Disequilibrium report
ARHGEF7
Human Gene Mutation Database (HGMD)
ARHGEF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF7 Gene

Disorders for ARHGEF7 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARHGEF7 Gene including...

Search for ARHGEF7 Gene in MalaCards »

(1) University of Copenhagen DISEASES for ARHGEF7 Gene

(2) Novoseek inferred disease relationships for ARHGEF7 Gene

Disease -log(P) Hits PubMed IDs
mental retardation 55.5 5
tumors 0 1

Relevant External Links for ARHGEF7

Genetic Association Database (GAD)
ARHGEF7
genes like me logo Genes that share disorders with ARHGEF7: view

No data available for UniProtKB/Swiss-Prot for ARHGEF7 Gene

Publications for ARHGEF7 Gene

  1. Mammalian Scribble forms a tight complex with the betaPIX exchange factor. (PMID: 15182672) Audebert S. … Borg J.-P. (Curr. Biol. 2004) 3 4 23
  2. A novel regulator of p21-activated kinases. (PMID: 9726964) Bagrodia S. … Cerione R.A. (J. Biol. Chem. 1998) 2 3 4
  3. Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. (PMID: 16329988) Park H.S. … Bae Y.S. (Biochem. Biophys. Res. Commun. 2006) 3 23
  4. Tiam1 and betaPIX mediate Rac-dependent endothelial barrier protective response to oxidized phospholipids. (PMID: 17219408) Birukova A.A. … Birukov K.G. (J. Cell. Physiol. 2007) 3 23
  5. Role of phospholipase Cgamma1 in cell spreading requires association with a beta-Pix/GIT1-containing complex, leading to activation of Cdc42 and Rac1. (PMID: 17562871) Jones N.P. … Katan M. (Mol. Cell. Biol. 2007) 3 23

Products for ARHGEF7 Gene

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Sources for ARHGEF7 Gene

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