ARHGEF7 Gene
protein-coding GIFtS: 65
GCID: GC13P111766
|
|
Rho guanine nucleotide exchange factor (GEF) 7
| |
Aliases
for ARHGEF7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho Guanine Nucleotide Exchange Factor (GEF) 71 2 | | KIAA01421 3 | | COOL11 2 3 5 | | COOL-12 3 | | PIXB1 2 3 5 | | PAK-Interacting Exchange Factor Beta2 3 | | P85SPR1 2 3 | | DKFZp686C121701 | | BETA-PIX1 2 | | DKFZp761K10211 | | Nbla103141 2 | | Guanine Nucleotide Exchange Factor 72 | | P501 2 | | Rho Guanine Nucleotide Exchange Factor 72 | | P50BP1 2 | | SH3 Domain-Containing Proline-Rich Protein2 | | P851 2 | | Beta-Pix3 | | P85COOL11 2 | | PAK3BP3 | | PAK31 2 | | P851 2 |
Export aliases for ARHGEF7 gene to outside databasesPrevious GC identifers: GC13P110166 GC13P106154 GC13P110604 GC13P109465 GC13P110565 GC13P092335 |
Summaries
for ARHGEF7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARHGEF7:
Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work throughG protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate theRas-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding proteinRac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiplealternatively spliced transcript variants encoding different isoforms have been described for this gene. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ARHG7_HUMAN, Q14155Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cellmigration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May functionas a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes theformation of spines and synapses in hippocampal neurons
Gene Wiki entry for ARHGEF7
|
Genomic Views
for ARHGEF7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000013.10 NC_018924.1 NT_009952.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGEF7 gene promoter:
FOXF2 p53 AML1a SREBP-1c Pax-2 Pax-2a AP-4 SREBP-1b SREBP-1a Pax-2b
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGEF7
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF7 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 13q34 Ensembl cytogenetic band: 13q34 HGNC cytogenetic band: 13q33.3ARHGEF7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 13 GeneLoc Exon Structure GeneLoc location for GC13P111766: view genomic region
(about GC identifiers)
Start:
|
111,766,906 bp from pter |
End:
|
111,958,084 bp from pter |
Size:
|
191,179 bases |
Orientation:
|
plus strand |
|
Proteins
for ARHGEF7 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARHG7_HUMAN, Q14155 (See
protein sequence)Recommended Name: Rho guanine nucleotide exchange factor 7 Size: 803 amino acids; 90012 Da
Subunit: Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with PTK2/FAK1and RAC1. Interacts with ITCH and PARVB (By similarity). Interacts with unphosphorylated PAK1. Interacts with SCRIB;interaction is direct and may play a role in regulation of apoptosis. Interacts with FRMPD4 (via N-terminus).Interacts with CaMK1. Interacts with BIN2
Subcellular location: Cell junction, focal adhesion (By similarity). Cell projection, ruffle (By similarity).Cytoplasm, cell cortex (By similarity). Cell projection, lamellipodium (By similarity). Note=Detected at celladhesions. A small proportion is detected at focal adhesions
Sequence caution: Sequence=AAH50521.1; Type=Erroneous initiation; Sequence=BAA09763.2; Type=Erroneous initiation;Sequence=CAD38906.1; Type=Erroneous initiation;
3 PDB 3D structures from  and Proteopedia  for ARHGEF7:1BY1 (3D)
1ZSG (3D)
2L3G (3D)
Secondary accessions: B1ALK6 B1ALK8 Q3LIA4 Q5W9H0 Q6P9G3 Q6PII2 Q86W63 Q8N3M1Alternative splicing: 6 isoforms: Q14155-4 Q14155-1 Q14155-2 Q14155-3 Q14155-5 Q14155-6 (Contains a phosphoserine at position 645. Contains a phosphoserine at position 664)Explore the universe of human proteins at neXtProt for ARHGEF7: NX_Q14155
Post-translational modifications:
Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by CaMK1;enhancement of GEF activity and downstream activation of RAC11
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14155
ARHGEF7 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001106983.1 NP_001106984.1 NP_001106985.1 NP_003890.1 NP_663788.1
ENSEMBL proteins: ENSP00000325994 ENSP00000406732 ENSP00000418043 ENSP00000418235 ENSP00000418067 ENSP00000218789 ENSP00000364888 ENSP00000420592 ENSP00000397068 ENSP00000389890 ENSP00000364875 ENSP00000417596 ENSP00000359657 ENSP00000364893 ENSP00000364891 ENSP00000364889 ENSP00000445384 Reactome Protein details: Q14155
Human Recombinant Protein Products:
Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table
ARHGEF7 for ontologies About GeneDecksing
ARHGEF7 Antibody Products:
Assay Products for ARHGEF7: |
Protein
Domains /
Families
for ARHGEF7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGEF7 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q14155ProtoNet protein and cluster: Q14155 4 Blocks protein families: IPB000219 DH domain IPB001452 SH3 domain signature IPB001715 Calponin-like actin-binding IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: ARHG7_HUMAN, Q14155Similarity: Contains 1 CH (calponin-homology) domainSimilarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 SH3 domain |
Function
for ARHGEF7 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARHG7_HUMAN, Q14155Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in cellmigration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May functionas a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade, promotes theformation of spines and synapses in hippocampal neurons
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF7 (see all 11)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF7 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF7 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity |
IDA | -- | | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- | | GO:0005543 | phospholipid binding |
IEA | -- | | GO:0019901 | protein kinase binding |
IPI | -- |
ARHGEF7 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for ARHGEF7:
|
Pathways & Interactions
for ARHGEF7 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/36 super-pathways (see all 36) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | GPCR Pathway | | | 3 | Development_A2B receptor- action via G-protein alpha s | | | 4 | Signaling by GPCR | | | 5 | G-AlphaQ Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for ARHGEF7
5/26 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGEF7 (see all 26)
2 
Cell Signaling Technology (CST) Pathways for ARHGEF7
4  GeneGo (Thomson Reuters) Pathways for ARHGEF7
5/9  BioSystems Pathways for ARHGEF7 (see all 9)
5/14 
Reactome Pathways for ARHGEF7 (see all 14)
1 
Kegg Pathway (Kegg details for ARHGEF7):
ARHGEF7 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGEF7
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/121 Interacting proteins for ARHGEF7 (Q141551, 2, 3 ENSP000003648934) via UniProtKB, MINT, STRING, and/or I2D (see all 121)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| SCRIB | Q141602, 3, ENSP000003494864 | MINT-62243 MINT-62246 MINT-7210759 MINT-62247 MINT-8114729 MINT-62244 MINT-62254 MINT-62250 MINT-7210792 I2D:
score=4 STRING: ENSP00000349486 | | CBL | P226812, 3, ENSP000002640334 | MINT-7211968 MINT-7211987 MINT-7211918 MINT-7211864 MINT-7211952 MINT-7212521 MINT-7211842 MINT-7211850 MINT-7212004 I2D:
score=2 STRING: ENSP00000264033 | | GIT1 | Q9Y2X71, 2, 3, ENSP000003783384 | EBI-717515,EBI-466061 MINT-7147308 MINT-7147263 MINT-1953491 I2D:
score=6 STRING: ENSP00000378338 | | PAK1 | Q131532, 3, ENSP000002785684 | MINT-7145222 MINT-7212681 MINT-7211931 MINT-1953612 MINT-7212697 I2D:
score=11 STRING: ENSP00000278568 | | CBLB | Q131912, 3, ENSP000002641224 | MINT-56630 MINT-56632 MINT-56631 I2D:
score=3 STRING: ENSP00000264122 |
About this table
Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13): About this table
ARHGEF7 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGEF7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ARHGEF7 for compounds About GeneDecksing
 Browse Tocris compounds for ARHGEF7
3 HMDB Compounds for ARHGEF7 About this table
10/11 Novoseek chemical compound relationships for ARHGEF7 gene (see all 11) About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| phosphatidylinositol |
76.8 |
40 |
1312663 (4), 7692230 (2), 8567177 (2), 1317864 (2) (see all 24) |
| tyrosine |
59.2 |
25 |
7692230 (3), 7504303 (2), 8918697 (2), 17093062 (2) (see all 17) |
| phosphotyrosine |
55 |
2 |
8391166 (1), 8265614 (1) |
| wortmannin |
54.7 |
1 |
11438654 (1) |
| phosphoinositide |
49.6 |
2 |
9642280 (1), 15679846 (1) |
| gtp |
35.8 |
1 |
17652093 (1) |
| nadph |
17.9 |
10 |
16329988 (2), 20167927 (2), 15121857 (1), 14688330 (1) |
| leucine |
10.1 |
2 |
12626503 (1), 11278242 (1) |
| glucose |
0 |
3 |
1768652 (1), 17259384 (1) |
| serine |
0 |
1 |
11096073 (1) |
Search CenterWatch for drugs/clinical trials and news about ARHGEF7 / ARHG7
|
Transcripts
for ARHGEF7 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGEF7 gene (5 alternative transcripts): NM_001113511.1 NM_001113512.1 NM_001113513.1 NM_003899.3 NM_145735.2 Unigene Cluster for ARHGEF7: Rho guanine nucleotide exchange factor (GEF) 7 Hs.508738 [show with all ESTs]Unigene Representative Sequence: BX64803018/21 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21): ENST00000483540 ENST00000317133 ENST00000449979 ENST00000491775 ENST00000469877
ENST00000466143 ENST00000218789(uc001vrv.4 uc001vrw.4) ENST00000375736
ENST00000478983 ENST00000467053 ENST00000426073(uc001vrx.4 uc010tjo.2)
ENST00000426768 ENST00000375723 ENST00000483189(uc010agn.1) ENST00000478679
ENST00000491688 ENST00000370623 ENST00000375741(uc001vrs.2 uc001vrr.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF7 (see all 11)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF7 (see all 5)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): ARHGEF7 (NM_003899) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF7 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF7 |
Additional cDNA sequence: AB075521.1 AB177848.1 AB177849.1 AJ844629.1 AJ844630.1 AJ844631.1 AJ844632.1 AJ844633.1 AK055476.1 AK093326.1 AK095058.1 AK295472.1 AK300157.1 AK300272.1 AK308897.1 AL831814.1 AL834228.1 BC033905.1 BC050521.1 BC060776.1 BX648030.1 BX648314.1 D63476.1 24/27 DOTS entries (see all 27): DT.317598 DT.101963903 DT.120770366 DT.91875174 DT.120770358 DT.100028266 DT.40123024 DT.454809 DT.100691475 DT.105651 DT.120770369 DT.99964771 DT.75124505 DT.120770311 DT.95289815 DT.120770288 DT.120770339 DT.92431352 DT.95361009 DT.100672880 DT.120770380 DT.120770385 DT.86838072 DT.91669283 24/272 AceView cDNA sequences (see all 272): AL834228 T82301 AI671644 CF136814 AA448037 BM719607 BM818046 BC060776 AW500439 AI380374 AA610358 BE501048 AI919082 BF436811 CR618781 BM930916 BM682904 AA527273 BU158913 AI261832 AW139757 T08407 AA738189 BE550895
GeneLoc Exon Structure
5/13 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF7 (see all 13) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9a | · | 9b | · | 9c | · | 9d | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ |
|---|
|
| SP1: | | | | | | | - | | - | | - | | - | | - | | | | | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20 | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23a | · | 23b | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b |
|---|
|
| SP1: | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | - | | | | | | - | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | - | | | | | | - | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | - | | | | - | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARHGEF7
|
Expression
for ARHGEF7 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGEF7 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGCTGGGCGT
About this image
See ARHGEF7 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGEF7
SOURCE GeneReport for Unigene cluster: Hs.508738
SABiosciences Expression via Pathway-Focused PCR Array including ARHGEF7:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF7
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF7 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF7 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF7 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF7 |
Orthologs
for ARHGEF7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGEF7 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ARHGEF71 |
Rho guanine nucleotide exchange factor (GEF) 7 |
83.35(n)
93.64(a) |
|
418761 XM_003640531.1 XP_003640579.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ARHGEF76-- |
-- |
82(a)6(a) |
1 ↔ 1possible ortholog |
3(104650415-104782134) 1(93923302-93949657) |
African clawed frog
(Xenopus laevis) |
Amphibia |
480117882 |
-- |
77.09(n) |
|
48011788 |
zebrafish
(Danio rerio) |
Actinopterygii |
arhgef7a1 |
Rho guanine nucleotide exchange factor (GEF) 7a |
71.28(n)
77.42(a) |
|
553493 NM_001123235.1 NP_001116707.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
rtGEF3 |
guanyl-nucleotide exchange factor |
45(a) |
|
38C5 -- |
worm
(Caenorhabditis elegans) |
Secernentea |
K11E4.43
pix-11 |
Src homology domain 33
Protein PIX-11 |
26(a)3
44.56(n)1
32.08(a)1 |
|
X(13759889-13768646)3
1814901 NM_077896.31 NP_510297.21 |
ENSEMBL Gene Tree for ARHGEF7 (if available)
TreeFam Gene Tree for ARHGEF7 (if available) |
Paralogs
for ARHGEF7 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGEF7 gene
- ARHGEF62 VAV12 PLEKHG22 PLEKHG32 PREX22 TIAM12 SPATA132 TIAM22
- ARHGEF92 VAV32 VAV22 ARHGEF42 PLEKHG12 PREX12
18/75 SIMAP similar genes for ARHGEF7 using alignment to 13 protein entries: ARHG7_HUMAN (see all proteins)
(see all similar genes):KIAA0142 SHANK3 ARHGEF6 VAV1 GRB2 NCF1B
NCF1C SH3KBP1 VAV3 ABI-2 ABI2 SHANK1
GRAPL PLCG1 variant protein GRAP ITSN1 NOSTRIN LASP1
ARHGEF7 for paralogs About GeneDecksing
|
Genomic Variants
for ARHGEF7 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 13 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGEF7 (111766906 - 111958084 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for ARHGEF7
4 CNVs: 8760 6999 3035 3925
Human Gene Mutation Database (HGMD): ARHGEF7
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF7 |
|
Disorders
/ Diseases
for ARHGEF7 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGEF7 for disorders About GeneDecksing
OMIM gene information: 605477
OMIM disorders: --
17  diseases for ARHGEF7: About MalaCardsborjeson-forssman-lehmann syndrome wiskott-aldrich syndrome intellectual disability adult t-cell leukemia
insulin resistance renal cell carcinoma squamous cell carcinoma t-cell leukemia
leukemia lung cancer carcinoma breast cancer
neuroblastoma immunodeficiency neuronitis adenocarcinoma
pancreatitis
1 disease from the University of Copenhagen DISEASES database for ARHGEF7:Intellectual disability 2 Novoseek disease relationships for ARHGEF7 gene About this table
Export disorders for ARHGEF7 gene to outside databases
|
Publications
for ARHGEF7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGEF7 gene, integrated from 9 sources (see all 191):
(articles sorted by number of sources associating them with ARHGEF7) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel regulator of p21-activated kinases. (PubMed id 9726964)1, 2, 3 Bagrodia S....Cerione R.A. (1998)
- Mammalian Scribble forms a tight complex with the betaPIX exchange factor. (PubMed id 15182672)1, 2, 9 Audebert S.... Borg J.-P. (2004)
- Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. (PubMed id 19118189)1, 2 Lee H.W....Kim E. (2008)
- Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. (PubMed id 19041750)1, 2 Zhan L....Muthuswamy S.K. (2008)
- Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK). (PubMed id 16101281)1, 2 Mott H.R.... Owen D. (2005)
- Alternative splice variants encoding unstable protein domains exist in the human brain. (PubMed id 15491607)1, 2 Homma K.... Nishikawa K. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. (PubMed id 9207241)1, 3 Oh W.K....Park D. (1997)
- Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 8590280)1, 2 Nagase T....Nomura N. (1995)
- Molecular interaction of NADPH oxidase 1 with betaPix and Nox Organizer 1. (PubMed id 16329988)1, 9 Park H.S.... Bae Y.S. (2006)
|
External Searches for ARHGEF7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARHGEF7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGEF7 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ARHGEF7 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARHGEF7 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARHGEF7 gene:
Search GeneIP for patents involving ARHGEF7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARHGEF7 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARHGEF7 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF7 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF7 | | | OriGene Protein Over-expression Lysate for ARHGEF7 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARHGEF7 | | OriGene 3'-UTR Clone for ARHGEF7 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF7 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF7 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ARHGEF7 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF7 |
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