Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ARHGEF7 Gene

protein-coding   GIFtS: 69
GCID: GC13P111766

Rho Guanine Nucleotide Exchange Factor (GEF) 7

  See ARHGEF7-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 71 2     P502
PAK-Interacting Exchange Factor Beta1 2 3     P50BP2
COOL12 3 5     P852
PIXB2 3 5     P85COOL12
Guanine Nucleotide Exchange Factor 71 2     PAK32
SH3 Domain-Containing Proline-Rich Protein1 2     Rho Guanine Nucleotide Exchange Factor 72
COOL-12 3     Beta-Pix3
P85SPR2 3     KIAA01423
rho1     PAK3BP3
BETA-PIX2     p853
Nbla103142     

External Ids:    HGNC: 156071   Entrez Gene: 88742   Ensembl: ENSG000001026067   OMIM: 6054775   UniProtKB: Q141553   

Export aliases for ARHGEF7 gene to outside databases

Previous GC identifers: GC13P110166 GC13P106154 GC13P110604 GC13P109465 GC13P110565 GC13P092335


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ARHGEF7 Gene:
Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work
through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that
activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small
GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce
membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been
described for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARHGEF7 Gene:
ARHGEF7 (Rho guanine nucleotide exchange factor (GEF) 7) is a protein-coding gene. Diseases associated with ARHGEF7 include borjeson-forssman-lehmann syndrome. GO annotations related to this gene include phospholipid binding and guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF6.

UniProtKB/Swiss-Prot: ARHG7_HUMAN, Q14155
Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in
cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May
function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade,
promotes the formation of spines and synapses in hippocampal neurons

Gene Wiki entry for ARHGEF7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGEF7 gene promoter:
         FOXF2   p53   AML1a   SREBP-1c   Pax-2   Pax-2a   AP-4   SREBP-1b   SREBP-1a   Pax-2b   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF7 promoter sequence
   Search Chromatin IP Primers for ARHGEF7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q33.3

ARHGEF7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF7 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P111766:  view genomic region     (about GC identifiers)

Start:
111,766,906 bp from pter      End:
111,958,084 bp from pter
Size:
191,179 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ARHG7_HUMAN, Q14155 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 7  
Size: 803 amino acids; 90012 Da
Subunit: Interacts with PAK kinases through the SH3 domain. Interacts with GIT1 and TGFB1I1. Interacts with
PTK2/FAK1 and RAC1. Interacts with ITCH and PARVB (By similarity). Interacts with unphosphorylated PAK1.
Interacts with SCRIB; interaction is direct and may play a role in regulation of apoptosis. Interacts with FRMPD4
(via N-terminus). Interacts with CaMK1. Interacts with BIN2. Isoform 1 and isoform 5 interact with SNX27
Sequence caution: Sequence=AAH50521.1; Type=Erroneous initiation; Sequence=BAA09763.2; Type=Erroneous initiation;
Sequence=CAD38906.1; Type=Erroneous initiation;
3 PDB 3D structures from and Proteopedia for ARHGEF7:
1BY1 (3D)        1ZSG (3D)        2L3G (3D)    
Secondary accessions: B1ALK6 B1ALK8 Q3LIA4 Q5W9H0 Q6P9G3 Q6PII2 Q86W63 Q8N3M1
Alternative splicing: 6 isoforms:  Q14155-4   Q14155-1   Q14155-2   Q14155-3   Q14155-5   Q14155-6   (Contains a phosphoserine at position 645. Contains a phosphoserine at position 664)

Explore the universe of human proteins at neXtProt for ARHGEF7: NX_Q14155

Explore proteomics data for ARHGEF7 at MOPED

Post-translational modifications: 

  • Phosphorylated by PTK2/FAK1; this promotes interaction with RAC1 (By similarity). Phosphorylated on Ser-694 by
    CaMK1; enhancement of GEF activity and downstream activation of RAC11
  • Ubiquitination2 at Lys524, Lys547, Lys598
  • Modification sites at PhosphoSitePlus

  • See ARHGEF7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001106983.1  NP_001106984.1  NP_001106985.1  NP_003890.1  NP_663788.1  

    ENSEMBL proteins: 
     ENSP00000325994   ENSP00000406732   ENSP00000418043   ENSP00000418067   ENSP00000418235  
     ENSP00000218789   ENSP00000364888   ENSP00000420592   ENSP00000397068   ENSP00000389890  
     ENSP00000364875   ENSP00000417596   ENSP00000359657   ENSP00000364893   ENSP00000364891  
     ENSP00000364889   ENSP00000445384  
    Reactome Protein details: Q14155

    ARHGEF7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ARHGEF7
    OriGene Protein Over-expression Lysate for ARHGEF7
    OriGene MassSpec for ARHGEF7
    OriGene Custom Protein Services for ARHGEF7
    GenScript Custom Purified and Recombinant Proteins Services for ARHGEF7
    Novus Biologicals ARHGEF7 Protein
    Novus Biologicals ARHGEF7 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARHGEF7

     
    Search eBioscience for Proteins for ARHGEF7 

    ARHGEF7 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ARHGEF7 
    OriGene Antibodies for ARHGEF7
    OriGene Custom Antibody Services for ARHGEF7
    Novus Biologicals ARHGEF7 Antibodies
    Abcam antibodies for ARHGEF7
    Cloud-Clone Corp. Antibodies for ARHGEF7
    ThermoFisher Antibodies for ARHGEF7
    LSBio Antibodies in human, mouse, rat for ARHGEF7

    ARHGEF7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARHGEF7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGEF7
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARHGEF7
    Cloud-Clone Corp. CLIAs for ARHGEF7
    Search eBioscience for ELISAs for ARHGEF7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 7):
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR011511 SH3_2

    Graphical View of Domain Structure for InterPro Entry Q14155

    ProtoNet protein and cluster: Q14155

    4 Blocks protein domains:
    IPB000219 DH domain
    IPB001452 SH3 domain signature
    IPB001715 Calponin-like actin-binding
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARHG7_HUMAN, Q14155
    Similarity: Contains 1 CH (calponin-homology) domain
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with ARHGEF7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHG7_HUMAN, Q14155
    Function: Acts as a RAC1 guanine nucleotide exchange factor (GEF) and can induce membrane ruffling. Functions in
    cell migration, attachment and cell spreading. Promotes targeting of RAC1 to focal adhesions (By similarity). May
    function as a positive regulator of apoptosis. Downstream of NMDA receptors and CaMKK-CaMK1 signaling cascade,
    promotes the formation of spines and synapses in hippocampal neurons

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity IDA--
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI11864573
    GO:0019901protein kinase binding IPI--
         
    Find genes that share ontologies with ARHGEF7           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARHGEF7:
     Decreased nuclei size in G2M 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGEF7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGEF7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGEF7

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARHGEF7:
    hsa-mir-20a-5p (MIRT050571), hsa-mir-18a-3p (MIRT040805), hsa-mir-24-3p (MIRT030425), hsa-mir-17-5p (MIRT050964)

    Block miRNA regulation of human, mouse, rat ARHGEF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF7 (see all 112):
    hsa-miR-323-3p hsa-miR-582-3p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-605 hsa-miR-3074-3p hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): ARHGEF7 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARHGEF7
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARHGEF7

    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGEF7 (see all 28)
    OriGene ORF clones in mouse, rat for ARHGEF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ARHGEF7 (NM_003899)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARHGEF7
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARHGEF7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ARHG7_HUMAN, Q14155: Cell junction, focal adhesion (By similarity). Cell projection, ruffle (By similarity).
    Cytoplasm, cell cortex (By similarity). Cell projection, lamellipodium (By similarity). Note=Detected at cell
    adhesions. A small proportion is detected at focal adhesions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    cytoskeleton2
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--
    GO:0005829cytosol TAS--
    GO:0005925focal adhesion IEA--
    GO:0005938cell cortex IEA--
    GO:0030027lamellipodium ISS--

    Find genes that share ontologies with ARHGEF7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ARHGEF7 About   (see all 37)  
    See pathways by source

    SuperPathContained pathways About
    1Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    2GPCR Pathway
    Ras Pathway0.73
    Pancreatic Adenocarcinoma0.59
    Paxillin Interactions0.73
    Breast Cancer Regulation by Stathmin10.58
    GPCR Pathway0.62
    3p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    G alpha (12/13) signalling events0.44
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5Signaling by FGFR
    Signaling by EGFR0.83
    Signalling by NGF0.71
    Signaling by EGFR in Cancer0.82


    Find genes that share SuperPaths with ARHGEF7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGEF7 (see all 26)
        RhoA Pathway
    Paxillin Interactions
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway

    2 Cell Signaling Technology (CST) Pathways for ARHGEF7
        Cytoskeletal Signaling
    Adhesion

    4 GeneGo (Thomson Reuters) Pathways for ARHGEF7
        Development A2A receptor signaling
    Development A2B receptor- action via G-protein alpha s
    Development Beta-adrenergic receptors signaling via cAMP
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation

    Selected BioSystems Pathways for ARHGEF7 (see all 9)
        Integrin-mediated cell adhesion
    Regulation of Actin Cytoskeleton
    Aurora A signaling
    CDC42 signaling events
    Regulation of CDC42 activity

    4 Reactome Pathways for ARHGEF7
        G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle
    EGFR downregulation


    1 Kegg Pathway  (Kegg details for ARHGEF7):
        Regulation of actin cytoskeleton

        Pathway & Disease-focused RT2 Profiler PCR Array including ARHGEF7: 
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARHGEF7

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGEF7 (Q141551, 2, 3 ENSP000003648934) via UniProtKB, MINT, STRING, and/or I2D (see all 130)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SCRIBQ141601, 2, 3, ENSP000003494864EBI-717515,EBI-357345 MINT-62243 MINT-62246 MINT-7210759 MINT-62247 MINT-8114729 MINT-62244 MINT-62254 MINT-62250 MINT-7210792 I2D: score=4 STRING: ENSP00000349486
    CBLP226811, 2, 3, ENSP000002640334EBI-717515,EBI-518228 MINT-7211968 MINT-7211987 MINT-7211918 MINT-7211864 MINT-7211952 MINT-7212521 MINT-7211842 MINT-7211850 MINT-7212004 I2D: score=2 STRING: ENSP00000264033
    RAC1P630001, 2, 3, ENSP000003484614EBI-717515,EBI-413628 MINT-7145306 MINT-7145341 MINT-7145246 MINT-7145235 MINT-7145257 MINT-7145327 MINT-7145361 I2D: score=3 STRING: ENSP00000348461
    PAK1Q131531, 2, 3, ENSP000002785684EBI-717515,EBI-1307 MINT-7145222 MINT-7212681 MINT-7211931 MINT-1953612 MINT-7212697 I2D: score=11 STRING: ENSP00000278568
    GIT1Q9Y2X71, 2, 3, ENSP000003783384EBI-717515,EBI-466061 MINT-7147308 MINT-7147263 MINT-1953491 I2D: score=6 STRING: ENSP00000378338
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction TAS9659915
    GO:0007173epidermal growth factor receptor signaling pathway TAS--
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007399nervous system development IEA--
    GO:0030032lamellipodium assembly ISS--

    Find genes that share ontologies with ARHGEF7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGEF7 (ARHG7)

    3 HMDB Compounds for ARHGEF7    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Selected Novoseek inferred chemical compound relationships for ARHGEF7 gene (see all 11)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 76.8 40 1312663 (4), 7692230 (2), 8567177 (2), 1317864 (2) (see all 24)
    tyrosine 59.2 25 7692230 (3), 7504303 (2), 8918697 (2), 17093062 (2) (see all 17)
    phosphotyrosine 55 2 8391166 (1), 8265614 (1)
    wortmannin 54.7 1 11438654 (1)
    phosphoinositide 49.6 2 9642280 (1), 15679846 (1)
    gtp 35.8 1 17652093 (1)
    nadph 17.9 10 16329988 (2), 20167927 (2), 15121857 (1), 14688330 (1)
    leucine 10.1 2 12626503 (1), 11278242 (1)
    glucose 0 3 1768652 (1), 17259384 (1)
    serine 0 1 11096073 (1)



    Find genes that share compounds with ARHGEF7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ARHGEF7 gene (5 alternative transcripts): 
    NM_001113511.1  NM_001113512.1  NM_001113513.1  NM_003899.3  NM_145735.2  

    Unigene Cluster for ARHGEF7:

    Rho guanine nucleotide exchange factor (GEF) 7
    Hs.508738  [show with all ESTs]
    Unigene Representative Sequence: BX648030
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000483540 ENST00000317133 ENST00000422836 ENST00000449979 ENST00000491775
    ENST00000466143 ENST00000469877 ENST00000218789(uc001vrv.4 uc001vrw.4)
    ENST00000375736 ENST00000467053 ENST00000426073(uc001vrx.4 uc010tjo.2)
    ENST00000426768 ENST00000375723 ENST00000483189(uc010agn.1) ENST00000478679
    ENST00000491688 ENST00000370623 ENST00000375741(uc001vrs.2 uc001vrr.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARHGEF7 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF7 (see all 112):
    hsa-miR-323-3p hsa-miR-582-3p hsa-miR-520e hsa-miR-520f hsa-miR-106a hsa-miR-605 hsa-miR-3074-3p hsa-miR-3653
    SwitchGear 3'UTR luciferase reporter plasmids (see all 2): ARHGEF7 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARHGEF7
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF7
    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGEF7 (see all 28)
    OriGene ORF clones in mouse, rat for ARHGEF7
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): ARHGEF7 (NM_003899)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF7
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGEF7
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF7
      QuantiFast Probe-based Assays in human, mouse, rat ARHGEF7

    Additional mRNA sequence: 

    AB075521.1 AB177848.1 AB177849.1 AJ844629.1 AJ844630.1 AJ844631.1 AJ844632.1 AJ844633.1 
    AK055476.1 AK093326.1 AK095058.1 AK295472.1 AK300157.1 AK300272.1 AK308897.1 AL831814.1 
    AL834228.1 BC033905.1 BC050521.1 BC060776.1 BX648030.1 BX648314.1 D63476.1 

    Selected DOTS entries (see all 27):

    DT.317598  DT.101963903  DT.120770366  DT.91875174  DT.120770358  DT.100028266  DT.40123024  DT.454809 
    DT.100691475  DT.105651  DT.120770369  DT.99964771  DT.75124505  DT.120770311  DT.95289815  DT.120770288 
    DT.120770339  DT.92431352  DT.95361009  DT.100672880  DT.120770380  DT.120770385  DT.86838072  DT.91669283 

    Selected AceView cDNA sequences (see all 272):

    AA737958 BQ922412 AA527273 AI573219 AA354483 AI919082 BC060776 BM930916 
    AI697674 AA258853 CB155275 BE501048 T82301 T16746 AA448633 AA610358 
    BM818046 CF136814 AA902292 BM684430 AA738189 CD722585 T08407 BE550895 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF7 (see all 13)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^
    SP1:                    -     -     -     -     -                 -     -           -     -     -                                                               
    SP2:                                                        -     -     -           -     -     -                                                               
    SP3:                                                                    -           -     -     -                                                               
    SP4:                    -     -     -     -     -           -     -     -           -     -     -                                                               
    SP5:                    -     -     -     -     -     -     -     -     -           -     -     -                                                               

    ExUns: 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b
    SP1:              -     -           -                                             
    SP2:              -     -           -                 -                           
    SP3:              -     -           -                 -                           
    SP4:              -     -           -                                             
    SP5:              -     -           -                                             


    ECgene alternative splicing isoforms for ARHGEF7

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ARHGEF7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGCTGGGCGT
    ARHGEF7 Expression
    About this image


    ARHGEF7 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 10 entries
             Cerebral Cortex
             Septum   
     
     Adipose (Muscoskeletal System)
    ARHGEF7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGEF7 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.508738
        Pathway & Disease-focused RT2 Profiler PCR Array including ARHGEF7: 
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF7
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGEF7
    QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF7
    QuantiFast Probe-based Assays in human, mouse, rat ARHGEF7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF7 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef71 , 5 Rho guanine nucleotide exchange factor (GEF7)1, 5 87.13(n)1
    94.5(a)1
      8 (5.73 cM)5
    541261  NM_001113517.11  NP_001106989.11 
     117281055 
    chicken
    (Gallus gallus)
    Aves ARHGEF71 Rho guanine nucleotide exchange factor (GEF) 7 83.35(n)
    93.64(a)
      418761  XM_003640531.2  XP_003640579.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF76
    Rho guanine nucleotide exchange factor (GEF) 7
    82(a)
    1 ↔ 1
    3(104649861-104784981)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480117882   -- 77.09(n)    48011788 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgef7a1 Rho guanine nucleotide exchange factor (GEF) 7a 71.28(n)
    77.42(a)
      553493  NM_001123235.1  NP_001116707.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta rtGEF3 guanyl-nucleotide exchange factor 45(a)   38C5   --
    worm
    (Caenorhabditis elegans)
    Secernentea K11E4.43
    pix-11
    Src homology domain 33
    pix-11
    26(a)3
    44.36(n)1
    31.48(a)1
      X(13759889-13768646)3
    1814901  NM_001270298.11  NP_001257227.11 


    ENSEMBL Gene Tree for ARHGEF7 (if available)
    TreeFam Gene Tree for ARHGEF7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ARHGEF7 gene
    ARHGEF62  PLEKHG22  PLEKHG32  PREX22  ENSG000002731672  TIAM12  SPATA132  TIAM22  
    ARHGEF92  ARHGEF42  PLEKHG12  PREX12  
    Selected SIMAP similar genes for ARHGEF7 using alignment to 13 protein entries:     ARHG7_HUMAN (see all proteins) (see all similar genes):
    KIAA0142    SHANK3    ARHGEF6    VAV1    GRB2    NCF1B
    NCF1C    SH3KBP1    VAV3    ABI-2    ABI2    SHANK1
    GRAPL    PLCG1 variant protein    GRAP    NOSTRIN    ITSN1    LASP1

    Find genes that share paralogs with ARHGEF7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ARHGEF7 (see all 4712)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421403611,2
    --92333262(+) TACCAC/TAGGCC 3 -- int10--------
    rs64923421,2
    C,F,A--92333334(+) aacatG/Agattg 3 -- int12Minor allele frequency- A:0.12WA 120
    rs1463472251,2
    C--92333338(+) TGGATG/TGCCAT 3 -- int10--------
    rs1901345081,2
    --92333344(+) GCCATA/GTCCAC 3 -- int10--------
    rs755876501,2
    C,F--92333448(+) TGGAAG/ATCACC 3 -- int11Minor allele frequency- A:0.02NA 120
    rs1834227081,2
    --92333606(+) ACAGAA/GAAGAA 3 -- int10--------
    rs784026871,2
    C,F--92333614(+) GAAAAG/TCTCCC 3 -- int11Minor allele frequency- T:0.05EA 120
    rs95153691,2
    C,F--92333679(+) cttgcG/Aggggg 3 -- int18Minor allele frequency- A:0.35NA CSA WA EA 368
    rs1883566381,2
    --92333721(+) AGCAGA/TGTGAG 3 -- int10--------
    rs1170808231,2
    C,F--92333728(+) TGAGAC/TTTCAT 3 -- int11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for ARHGEF7 (111766906 - 111958084 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARHGEF7 (see all 17):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2748054CNV Deletion23290073
    esv2748058CNV Deletion23290073
    dgv269e201CNV Deletion23290073
    esv2748059CNV Deletion23290073
    esv2748057CNV Deletion23290073
    esv2748056CNV Deletion23290073
    esv2748055CNV Deletion23290073
    esv2748050CNV Deletion23290073
    dgv268e201CNV Deletion23290073
    esv1576482CNV Deletion17803354

    Human Gene Mutation Database (HGMD): ARHGEF7
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGEF7
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGEF7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 605477    OMIM disorders: --

    1 disease for ARHGEF7:    
    About MalaCards
    borjeson-forssman-lehmann syndrome

    1 disease from the University of Copenhagen DISEASES database for ARHGEF7:
    Intellectual disability

    Find genes that share disorders with ARHGEF7           About GenesLikeMe

    2 Novoseek inferred disease relationships for ARHGEF7 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    mental retardation 55.5 5 17317956 (1), 12810981 (1), 15800193 (1), 11017088 (1) (see all 5)
    tumors 0 1 11502199 (1)

    Genetic Association Database (GAD): ARHGEF7

    Export disorders for ARHGEF7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ARHGEF7 gene, integrated from 10 sources (see all 202):
    (articles sorted by number of sources associating them with ARHGEF7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel regulator of p21-activated kinases. (PubMed id 9726964)1, 2, 3 Bagrodia S.... Cerione R.A. (J. Biol. Chem. 1998)
    2. Mammalian Scribble forms a tight complex with the betaPIX exchange factor. (PubMed id 15182672)1, 2, 9 Audebert S.... Borg J.-P. (Curr. Biol. 2004)
    3. Sorting nexin 27 protein regulates trafficking of a p21-activated kinase (PAK) interacting exchange factor (beta-Pix)-G protein-coupled receptor kinase interacting protein (GIT) complex via a PDZ domain interaction. (PubMed id 21926430)1, 2 Valdes J.L.... Playford M.P. (J. Biol. Chem. 2011)
    4. Genome-wide association meta-analysis for total serum bilirubin levels. (PubMed id 19414484)1, 4 Johnson A.D.... Witteman J.C. (Hum. Mol. Genet. 2009)
    5. Loci at chromosomes 13, 19 and 20 influence age at natural menopause. (PubMed id 19448619)1, 4 Stolk L....Uitterlinden A.G. (Nat. Genet. 2009)
    6. Preso, a novel PSD-95-interacting FERM and PDZ domain protein that regulates dendritic spine morphogenesis. (PubMed id 19118189)1, 2 Lee H.W.... Kim E. (J. Neurosci. 2008)
    7. Deregulation of scribble promotes mammary tumorigenesis and reveals a role for cell polarity in carcinoma. (PubMed id 19041750)1, 2 Zhan L.... Muthuswamy S.K. (Cell 2008)
    8. Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK). (PubMed id 16101281)1, 2 Mott H.R.... Owen D. (Biochemistry 2005)
    9. Alternative splice variants encoding unstable protein domains exist in the human brain. (PubMed id 15491607)1, 2 Homma K.... Nishikawa K. (J. Mol. Biol. 2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 8874 HGNC: 15607 AceView: ARHGEF7 Ensembl:ENSG00000102606 euGenes: HUgn8874
    ECgene: ARHGEF7 Kegg: 8874 H-InvDB: ARHGEF7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0142

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ARHGEF7 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARHGEF7 gene:
    Search GeneIP for patents involving ARHGEF7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ARHGEF7   OriGene RNAi products in human, mouse, rat for ARHGEF7  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for ARHGEF7  
     OriGene MassSpec something-or-other for ARHGEF7   OriGene clones in human, mouse for ARHGEF7  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF7   OriGene Purified Protein for ARHGEF7  
     OriGene ORF clones in mouse, rat for ARHGEF7   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARHGEF7   OriGene Custom Protein Services for ARHGEF7  

     
     
     Block miRNA regulation of human, mouse, rat ARHGEF7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ARHGEF7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF7 Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF7
     QuantiFast Probe-based Assays in human, mouse, rat ARHGEF7 QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF7
     PCR Arrays including human, mouse, rat ARHGEF7 Search Chromatin IP Primers for ARHGEF7
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGEF7  GeneGlobe Interaction Network for ARHGEF7
     Regulatory tfbs in ARHGEF7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ARHGEF7 GenScript cDNA clones with any tag delivered in your preferred vector for ARHGEF7
     GenScript Custom Assay Services for ARHGEF7 GenScript Custom overexpressing Cell Line Services for ARHGEF7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for ARHGEF7 

     Search Tocris compounds for ARHGEF7 (ARHG7)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ARHGEF7 antibodies
     ARHGEF7 proteins
     ARHGEF7 lysates
     Antibodies for ARHGEF7
     See all of Abcam's Antibodies, Kits and Proteins for ARHGEF7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ARHGEF7
     Antibodies for ARHGEF7
     ELISAs for ARHGEF7
     CLIAs for ARHGEF7



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARHGEF7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF7
     SwitchGear 3'UTR luciferase reporter plasmids for ARHGEF7
     SwitchGear Promoter luciferase reporter plasmids for ARHGEF7
     ThermoFisher Antibodies for ARHGEF7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGEF7
     LSBio Antibodies in human, mouse, rat for ARHGEF7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ARHGEF7
      Search eBioscience for proteins for ARHGEF7
      Search eBioscience for elisas for ARHGEF7
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARHGEF7 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4