Aliases for ARHGEF6 Gene
External Ids for ARHGEF6 Gene
Previous HGNC Symbols for ARHGEF6 Gene
Previous GeneCards Identifiers for ARHGEF6 Gene
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific mental retardation. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGEF6 Gene
ARHGEF6 (Rac/Cdc42 Guanine Nucleotide Exchange Factor 6) is a Protein Coding gene. Diseases associated with ARHGEF6 include Non-Syndromic X-Linked Intellectual Disability and Supraglottis Cancer. Among its related pathways are Signaling by GPCR and GPCR Pathway. GO annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF7.
UniProtKB/Swiss-Prot for ARHGEF6 Gene
Acts as a RAC1 guanine nucleotide exchange factor (GEF).