Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARHGEF5 Gene

Aliases for ARHGEF5 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 5 2 3
  • Transforming Immortalized Mammary Oncogene 2 3 4
  • Guanine Nucleotide Regulatory Protein TIM 2 3 4
  • Oncogene TIM 3 4
  • Ephexin-3 3 4
  • P60 TIM 3 4
  • TIM 3 4
  • GEF5 3
  • TIM1 3
  • P60 3

External Ids for ARHGEF5 Gene

Previous GeneCards Identifiers for ARHGEF5 Gene

  • GC07P142309
  • GC07P143376
  • GC07P143454
  • GC07P143453
  • GC07P143428
  • GC07P143500
  • GC07P143683
  • GC07P144052
  • GC07P138140

Summaries for ARHGEF5 Gene

Entrez Gene Summary for ARHGEF5 Gene

  • Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF5 Gene

ARHGEF5 (Rho Guanine Nucleotide Exchange Factor (GEF) 5) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include GTP binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.

Gene Wiki entry for ARHGEF5 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF5 Gene

Genomics for ARHGEF5 Gene

Genomic Location for ARHGEF5 Gene

144,355,288 bp from pter
144,380,632 bp from pter
25,345 bases
Plus strand

Genomic View for ARHGEF5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF5 Gene

Proteins for ARHGEF5 Gene

  • Protein details for ARHGEF5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 5
    Protein Accession:
    Secondary Accessions:
    • A6NNJ2
    • Q6ZML7

    Protein attributes for ARHGEF5 Gene

    1597 amino acids
    Molecular mass:
    176799 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAD18708.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF5 Gene


neXtProt entry for ARHGEF5 Gene

Proteomics data for ARHGEF5 Gene at MOPED

Post-translational modifications for ARHGEF5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF5 Gene

Antibody Products

No data available for DME Specific Peptides for ARHGEF5 Gene

Domains & Families for ARHGEF5 Gene

Gene Families for ARHGEF5 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGEF5: view

Function for ARHGEF5 Gene

Gene Ontology (GO) - Molecular Function for ARHGEF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IDA 15601624
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 21988832
GO:0005525 GTP binding TAS 8134109
genes like me logo Genes that share ontologies with ARHGEF5: view
genes like me logo Genes that share phenotypes with ARHGEF5: view

Animal Models for ARHGEF5 Gene

MGI Knock Outs for ARHGEF5:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ARHGEF5 Gene

Localization for ARHGEF5 Gene

Subcellular locations from

Jensen Localization Image for ARHGEF5 Gene COMPARTMENTS Subcellular localization image for ARHGEF5 gene
Compartment Confidence
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ARHGEF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IDA 14662653
GO:0005737 cytoplasm IDA 14662653
GO:0071944 cell periphery IDA 25911094
genes like me logo Genes that share ontologies with ARHGEF5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF5 Gene

Pathways & Interactions for ARHGEF5 Gene

genes like me logo Genes that share pathways with ARHGEF5: view

Pathways by source for ARHGEF5 Gene

1 BioSystems pathway for ARHGEF5 Gene

Gene Ontology (GO) - Biological Process for ARHGEF5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002408 myeloid dendritic cell chemotaxis IEA --
GO:0030036 actin cytoskeleton organization IEA --
GO:0032956 regulation of actin cytoskeleton organization IMP 14662653
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with ARHGEF5: view

No data available for SIGNOR curated interactions for ARHGEF5 Gene

Drugs & Compounds for ARHGEF5 Gene

No Compound Related Data Available

Transcripts for ARHGEF5 Gene

Unigene Clusters for ARHGEF5 Gene

Rho guanine nucleotide exchange factor (GEF) 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGEF5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF5 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a ·
SP1: - -
SP2: - -
SP4: - - - -
SP5: -
SP9: - - - - - - - - -
SP11: -

ExUns: 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23
SP1: -

Relevant External Links for ARHGEF5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGEF5 Gene

mRNA expression in normal human tissues for ARHGEF5 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGEF5 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x6.0), Skin - Not Sun Exposed (Suprapubic) (x5.1), and Esophagus - Mucosa (x4.2).

Protein differential expression in normal tissues from HIPED for ARHGEF5 Gene

This gene is overexpressed in Breast (30.6) and Placenta (23.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGEF5 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF5 Gene Hs.334

mRNA Expression by UniProt/SwissProt for ARHGEF5 Gene

Tissue specificity: Mainly expressed in kidney, liver, pancreas, lung and placenta
genes like me logo Genes that share expression patterns with ARHGEF5: view

Protein tissue co-expression partners for ARHGEF5 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for ARHGEF5 Gene

Orthologs for ARHGEF5 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF5 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARHGEF5 35
  • 75.88 (n)
  • 66.56 (a)
  • 66 (a)
(Canis familiaris)
Mammalia ARHGEF5 35
  • 78.33 (n)
  • 69.71 (a)
  • 68 (a)
(Mus musculus)
Mammalia Arhgef5 35
  • 74.91 (n)
  • 66.69 (a)
Arhgef5 16
Arhgef5 36
  • 66 (a)
(Pan troglodytes)
Mammalia ARHGEF5 35
  • 99.31 (n)
  • 99 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Arhgef5 35
  • 74.56 (n)
  • 65.91 (a)
(Monodelphis domestica)
Mammalia ARHGEF5 36
  • 46 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGEF5 36
  • 75 (a)
(Gallus gallus)
Aves ARHGEF5 36
  • 70 (a)
(Anolis carolinensis)
Reptilia ARHGEF5 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3231 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32005 35
(Danio rerio)
Actinopterygii ARHGEF5 36
  • 24 (a)
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH03693 37
  • 32 (a)
Exn 36
  • 14 (a)
(Caenorhabditis elegans)
Secernentea K07D4.7a 37
  • 34 (a)
K07D4.7b 37
  • 34 (a)
ephx-1 36
  • 18 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
Species with no ortholog for ARHGEF5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF5 Gene

Gene Tree for ARHGEF5 (if available)
Gene Tree for ARHGEF5 (if available)

Paralogs for ARHGEF5 Gene

Paralogs for ARHGEF5 Gene

(7) SIMAP similar genes for ARHGEF5 Gene using alignment to 5 proteins: Pseudogenes for ARHGEF5 Gene

genes like me logo Genes that share paralogs with ARHGEF5: view

Variants for ARHGEF5 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF5 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs186573263 -- 144,380,026(+) ACTGC(C/G)AAACT reference, synonymous-codon
rs186283982 -- 144,379,417(+) ATTGG(C/T)CAGGC intron-variant
rs185706133 -- 144,377,293(+) ATTTA(C/T)TGATA intron-variant
rs185315992 -- 144,361,001(+) GAGGC(G/T)GGTGG intron-variant
rs185205268 -- 144,378,024(+) AAGGC(A/G)GTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF5 Gene

Variant ID Type Subtype PubMed ID
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
nsv8227 CNV Gain+Loss 18304495
dgv2149e1 CNV Complex 17122850
nsv7411 OTHER Inversion 18451855
dgv7522n71 CNV Gain 21882294
dgv7524n71 CNV Gain+Loss 21882294
dgv7525n71 CNV Loss 21882294
nsv821609 CNV Duplication 20802225
nsv824360 CNV Gain 20364138
dgv24n31 CNV Duplication 19718026
nsv819701 CNV Insertion 19587683
esv24292 CNV Gain+Loss 19812545
nsv831175 CNV Loss 17160897
nsv469769 CNV Complex 16826518
nsv471646 CNV Gain+Loss 15918152
dgv7526n71 CNV Gain 21882294
dgv7527n71 CNV Loss 21882294
nsv831177 CNV Loss 17160897
nsv515042 CNV Complex 21397061
nsv471456 CNV Duplication 19718026
nsv482117 CNV Gain 20164927
nsv889377 CNV Loss 21882294

Variation tolerance for ARHGEF5 Gene

Gene Damage Index Score: 1.99; 36.77% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF5 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF5 Gene

Disorders for ARHGEF5 Gene

Relevant External Links for ARHGEF5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARHGEF5: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF5 Gene

Publications for ARHGEF5 Gene

  1. Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins. (PMID: 8134109) Chan A.M.-L. … Miki T. (Oncogene 1994) 2 23 67
  2. Assignment of the human TIM proto-oncogene to 7q33-->q35. (PMID: 7656213) Takai S. … Miki T. (Cancer Genet. Cytogenet. 1995) 2 67
  3. Induction of transforming growth factor beta 1 resistance by the E1A oncogene requires binding to a specific set of cellular proteins. (PMID: 1673033) Missero C. … Dotto G.P. (Proc. Natl. Acad. Sci. U.S.A. 1991) 23 67
  4. A complex pattern of translational initiation and phosphorylation in L-myc proteins. (PMID: 1849244) Dosaka-Akita H. … Birrer M.J. (Oncogene 1991) 23 67
  5. Odontogenic Ameloblast-associated Protein (ODAM) Mediates Junctional Epithelium Attachment to Teeth via Integrin-ODAM-Rho Guanine Nucleotide Exchange Factor 5 (ARHGEF5)-RhoA Signaling. (PMID: 25911094) Lee H.K. … Park J.C. (J. Biol. Chem. 2015) 67

Products for ARHGEF5 Gene

Sources for ARHGEF5 Gene

Back to Top