Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGEF5 Gene

protein-coding   GIFtS: 59
GCID: GC07P144052

Rho Guanine Nucleotide Exchange Factor (GEF) 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 51 2     GEF52
Guanine Nucleotide Regulatory Protein TIM1 2 3     P602
Transforming Immortalized Mammary Oncogene1 2 3     TIM12
TIM2 3 5     ephexin-32
Oncogene TIM2 3     Rho Guanine Nucleotide Exchange Factor 52
P60 TIM2 3     Ephexin-33

External Ids:    HGNC: 132091   Entrez Gene: 79842   Ensembl: ENSG000000503277   OMIM: 6008885   UniProtKB: Q127743   

Export aliases for ARHGEF5 gene to outside databases

Previous GC identifers: GC07P142309 GC07P143376 GC07P143454 GC07P143453 GC07P143428 GC07P143500 GC07P143683 GC07P138140


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGEF5 Gene:
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work
through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate
Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ARHGEF5 Gene: 
ARHGEF5 (Rho guanine nucleotide exchange factor (GEF) 5) is a protein-coding gene. Diseases associated with ARHGEF5 include hepatocellular carcinoma, and adenocarcinoma, and among its related super-pathways are Ras Pathway and G-AlphaQ Signaling. GO annotations related to this gene include GTP binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.

Gene Wiki entry for ARHGEF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.2  NT_007914.15  NT_079596.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGEF5 gene promoter:
         AML1a   p53   NRSF form 1   XBP-1   NF-kappaB   NRSF form 2   c-Ets-1   FOXJ2 (long isoform)   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ARHGEF5 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGEF5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q35

ARHGEF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P144052:  view genomic region     (about GC identifiers)

Start:
144,052,381 bp from pter      End:
144,077,725 bp from pter
Size:
25,345 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 143,390,747-143,415,984     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARHG5_HUMAN, Q12774 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 5  
Size: 1597 amino acids; 176799 Da
Sequence caution: Sequence=BAD18708.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NNJ2 Q6ZML7
Alternative splicing: 2 isoforms:  Q12774-1   Q12774-2   

Explore the universe of human proteins at neXtProt for ARHGEF5: NX_Q12774

Explore proteomics data for ARHGEF5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q12774

  • ARHGEF5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGEF5 Protein Expression
    REFSEQ proteins: NP_005426.2  
    ENSEMBL proteins: 
     ENSP00000417979   ENSP00000056217   ENSP00000418745   ENSP00000418227  

    Human Recombinant Protein Products for ARHGEF5: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for ARHGEF5
    GenScript Custom Purified and Recombinant Proteins Services for ARHGEF5
    Novus Biologicals ARHGEF5 Protein
    Novus Biologicals ARHGEF5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARHGEF5 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    ARHGEF5 for ontologies           About GeneDecksing



    ARHGEF5 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ARHGEF5
    OriGene Custom Antibody Services for ARHGEF5
    GenScript Custom Superior Antibodies Services for ARHGEF5
    Novus Biologicals ARHGEF5 Antibodies
    Abcam antibodies for ARHGEF5
    Cloud-Clone Corp. Antibodies for ARHGEF5 
    ThermoFisher Antibodies for ARHGEF5
    LSBio Antibodies in human, mouse, rat for ARHGEF5 

    Assay Products for ARHGEF5: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARHGEF5
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGEF5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARHGEF5 
    Cloud-Clone Corp. CLIAs for ARHGEF5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGEF: Rho guanine nucleotide exchange factors

    5 InterPro protein domains:
     IPR001331 GDS_CDC24_CS
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q12774

    ProtoNet protein and cluster: Q12774

    4 Blocks protein domains:
    IPB000219 DH domain
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: ARHG5_HUMAN, Q12774
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SH3 domain


    ARHGEF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding ----
    GO:0005525GTP binding TAS8134109
    GO:0005543phospholipid binding IEA--
         
    ARHGEF5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGEF5:
     Decreased focal adhesion (FA)   Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Arhgef5):
     hematopoietic system  immune system  nervous system  no phenotypic analysis 

    ARHGEF5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ARHGEF5: Arhgef5tm1.2Meg Arhgef5tm1.1Dwu

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGEF5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARHGEF5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGEF5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGEF5 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGEF5
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGEF5:
    hsa-miR-130a* hsa-miR-23c hsa-miR-199a-5p hsa-miR-23b hsa-miR-199b-5p hsa-miR-330-3p hsa-miR-23a hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARHGEF5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARHGEF5
    Sirion Biotech Customized adenovirus for overexpression of ARHGEF5

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ARHGEF5 (see all 5)
    OriGene ORF clones in mouse, rat for ARHGEF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARHGEF5 (NM_005435)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARHGEF5
    Search LifeMap BioReagents cell lines for ARHGEF5
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGEF5 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Pancreatic Adenocarcinoma0.59
    GPCR Pathway0.62
    Breast Cancer Regulation by Stathmin10.58
    2G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    Thrombin Signaling0.40
    G-AlphaI Signaling0.47
    3Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    4fMLP Pathway
    CXCR4 Pathway0.39
    Internalin Pathway0.31
    5CREB Pathway
    Activation of PKC through GPCR0.63

    5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGEF5 (see all 21)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling

    1 BioSystems Pathway for ARHGEF5
        Regulation of RhoA activity


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGEF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/15 Interacting proteins for ARHGEF5 (Q127742, 3 ENSP000000562174) via UniProtKB, MINT, STRING, and/or I2D (see all 15)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED28Q9H2042, 3, ENSP000002373804MINT-7041853 I2D: score=1 STRING: ENSP00000237380
    SFNP319472, 3MINT-3974875 I2D: score=2 
    PLCG1P191743, ENSP000002440074I2D: score=2 STRING: ENSP00000244007
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    SHC1P293533I2D: score=1 
    About this table

    Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002408myeloid dendritic cell chemotaxis IEA--
    GO:0030036actin cytoskeleton organization IEA--
    GO:0032319regulation of Rho GTPase activity IDA--
    GO:0032321positive regulation of Rho GTPase activity IEA--
    GO:0035023regulation of Rho protein signal transduction ----

    ARHGEF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGEF5 (ARHG5)

    Search CenterWatch for drugs/clinical trials and news about ARHGEF5 / ARHG5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGEF5 gene (2 alternative transcripts): 
    NM_005435.3  NM_001002861.1  

    Unigene Cluster for ARHGEF5:

    Rho guanine nucleotide exchange factor (GEF) 5
    Hs.334  [show with all ESTs]
    Unigene Representative Sequence: AK160365
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498580 ENST00000056217(uc003wek.3 uc003wel.3) ENST00000474817
    ENST00000471847(uc003wem.3)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGEF5
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGEF5:
    hsa-miR-130a* hsa-miR-23c hsa-miR-199a-5p hsa-miR-23b hsa-miR-199b-5p hsa-miR-330-3p hsa-miR-23a hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARHGEF5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF5
    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGEF5 (see all 5)
    OriGene ORF clones in mouse, rat for ARHGEF5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARHGEF5 (NM_005435)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF5
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ARHGEF5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF5

    Additional mRNA sequence: 

    AK090570.1 AK123596.1 AK160365.1 BC010046.2 BC011839.2 BC014555.2 BC136661.1 BX649178.1 
    CR749203.1 U02082.1 

    12 DOTS entries:

    DT.453361  DT.95088786  DT.100751897  DT.102835723  DT.91816105  DT.95373267  DT.91743124  DT.121037323 
    DT.102769  DT.102845469  DT.111011  DT.91763563 

    24/176 AceView cDNA sequences (see all 176):

    AI521839 BV178746 CD517373 AI370486 BM712072 BE501425 C21270 BG286254 
    AI650944 BM670360 BQ953504 AW663444 BI020419 AA502595 AI079550 CB216819 
    AA595157 AA704519 BE873295 AI339573 BQ935989 BG822939 CR749203 AW975832 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF5 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a ·
    SP1:                                                                                                        -                                   -               
    SP2:                                                                                                  -     -                                                   
    SP3:                                                                                                                                                            
    SP4:                    -                       -     -     -                                                                                                   
    SP5:                                      -                                                                                                                     

    ExUns: 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23
    SP1:                                            -                     
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for ARHGEF5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGEF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAGGGCTG
    ARHGEF5 Expression
    About this image


    See ARHGEF5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGEF5

    SOURCE GeneReport for Unigene cluster: Hs.334

    UniProtKB/Swiss-Prot: ARHG5_HUMAN, Q12774
    Tissue specificity: Mainly expressed in kidney, liver, pancreas, lung and placenta

        SABiosciences Custom PCR Arrays for ARHGEF5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF5
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat ARHGEF5
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF5
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF5 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef51 , 5 Rho guanine nucleotide exchange factor (GEF) 51, 5 74.99(n)1
    66.94(a)1
      6 (21.15 cM)5
    543241  NM_133674.11  NP_598435.11 
     432655825 
    chicken
    (Gallus gallus)
    Aves ARHGEF56
    Rho guanine nucleotide exchange factor (GEF) 5
    68(a)
    1 ↔ 1
    1(74562445-74577343)
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF56
    Rho guanine nucleotide exchange factor (GEF) 5
    64(a)
    1 ↔ 1
    5(82113534-82159136)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.320052 Xenopus laevis transcribed sequence with weak similarity to protein refNP_005426.1 (H.sapiens) Rho guanine nucleotide exchange factor 5; oncogene TIM; transforming immortalized mammary oncogene; guanine nucleotide regulatory protein TIM [Homo sapiens] less 77.85(n)    CA793729.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wu:fd16d016
    ARHGEF56
    Rho guanine nucleotide exchange factor (GEF) 5
    42(a)
    20(a)
    possible ortholog
    1 ↔ 1
    6(40497429-40503239)
    16(19677195-19699399)
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH036933   -- 32(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea K07D4.7a3   -- 34(a)
    (best of 2)
      II(4004982-4015768)   --


    ENSEMBL Gene Tree for ARHGEF5 (if available)
    TreeFam Gene Tree for ARHGEF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGEF5 gene
    ARHGEF192  ARHGEF152  ARHGEF162  NGEF2  ARHGEF262  
    7 SIMAP similar genes for ARHGEF5 using alignment to 5 protein entries:     ARHG5_HUMAN (see all proteins):
    ARHGEF35    LOC728377    DKFZp686N1969    SH3GL1    ARHGEF19    ARHGEF16
    NGEF

    ARHGEF5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ARHGEF5
    PGOHUM00000233061 PGOHUM00000250918


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/249 SNPs in ARHGEF5 are shown (see all 249)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011767141,2
    C--144050932(+) GATCTA/GGAAAT 1 -- us2k10--------
    rs2022464831,2
    C--144050991(+) AAATAC/GGCAAG 1 -- us2k10--------
    rs712063401,2
    C--144051238(+) CTAAC-/AGAACA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs26995121,2
    --144051922(-) TTGTTG/TTTTCT 1 -- us2k10--------
    rs624855161,2
    C--144051991(+) AACCAA/GTGAGG 1 -- us2k10--------
    rs1996429641,2
    F--144053995(+) GCCACG/ATTACA 1 -- int11Minor allele frequency- A:0.35EU 121
    rs2015142841,2
    C--144054503(+) ACACAC/TTGTAG 1 -- int10--------
    rs1457467771,2
    C--144054518(+) CAGTGA/GTCCAG 1 -- int10--------
    rs1997337311,2
    C--144054641(+) GATTTG/TTAAGT 1 -- int10--------
    rs1399349611,2
    C--144054681(+) AATCCA/GGGAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ARHGEF5 (144052381 - 144077725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/23 variations for ARHGEF5 (see all 23):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv24n31CNV Duplication19718026
    nsv471456CNV Duplication19718026
    nsv821609CNV Duplication20802225
    nsv819701CNV Insertion19587683
    nsv831177CNV Loss17160897
    dgv7527n71CNV Loss21882294
    nsv889377CNV Loss21882294
    nsv831175CNV Loss17160897
    dgv7525n71CNV Loss21882294
    dgv7526n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGEF5
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGEF5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600888    OMIM disorders: --

    4 diseases for ARHGEF5:    About MalaCards
    hepatocellular carcinoma    adenocarcinoma    pancreatitis    breast cancer


    ARHGEF5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGEF5
    Human Genome Epidemiology (HuGE) Navigator: ARHGEF5 (3 documents)

    Export disorders for ARHGEF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGEF5 gene, integrated from 9 sources (see all 33):
    (articles sorted by number of sources associating them with ARHGEF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins. (PubMed id 8134109)1, 2, 3, 9 Chan A.M.-L.... Miki T. (1994)
    2. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
    5. Assignment of the human TIM proto-oncogene to 7q33-->q35. (PubMed id 7656213)1, 3 Takai S....Miki T. (1995)
    6. Large-scale genotyping identifies 41 new loci associat ed with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (2013)
    7. Exome sequencing reveals new causal mutations in child ren with epileptic encephalopathies. (PubMed id 23647072)1 Veeramah K.R....Hammer M.F. (2013)
    8. Human Tim-Tipin complex affects the biochemical proper ties of the replicative DNA helicase and DNA polymerases. (PubMed id 23359676)1 Cho W.H....Lee J.K. (2013)
    9. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7984 HGNC: 13209 AceView: OR2A7 Ensembl:ENSG00000050327 euGenes: HUgn7984
    ECgene: ARHGEF5 H-InvDB: ARHGEF5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGEF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARHGEF5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGEF5 gene:
    Search GeneIP for patents involving ARHGEF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ARHGEF5   OriGene RNAi products in human, mouse, rat for ARHGEF5  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ARHGEF5  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF5   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ARHGEF5   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARHGEF5   OriGene Custom Protein Services for ARHGEF5  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGEF5
     QIAGEN SeqTarget long-range PCR primers for resequencing ARHGEF5
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF5
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF5
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF5
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF5
     GenScript Custom Purified and Recombinant Proteins Services for ARHGEF5 GenScript cDNA clones with any tag delivered in your preferred vector for ARHGEF5
     GenScript Custom Assay Services for ARHGEF5 GenScript Custom Superior Antibodies Services for ARHGEF5
     GenScript Custom overexpressing Cell Line Services for ARHGEF5 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARHGEF5 promoter
     Search Chromatin IP Primers for ARHGEF5
     RT2 qPCR Primer Assay in human, mouse / rat ARHGEF5
     Search GNC Networks for ARHGEF5
     SABiosciences PCR Arrays including human, mouse / rat ARHGEF5
     Search Tocris compounds for ARHGEF5 (ARHG5)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARHGEF5 antibodies
     ARHGEF5 proteins
     ARHGEF5 lysates
     Antibodies for ARHGEF5
     See all of Abcam's Antibodies, Kits and Proteins for ARHGEF5
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ARHGEF5
     Antibodies for ARHGEF5
     ELISAs for ARHGEF5
     CLIAs for ARHGEF5
     Search LifeMap BioReagents cell lines for ARHGEF5
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF5
     SwitchGear 3'UTR luciferase reporter plasmids for ARHGEF5
     SwitchGear Promoter luciferase reporter plasmids for ARHGEF5
     ThermoFisher Antibodies for ARHGEF5
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF5
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGEF5
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARHGEF5
    Customized:
     lentivirus for stable overexpression
     lentivirus expression plasmids for stable overexpression
     adenovirus for overexpression of ARHGEF5
     LSBio Antibodies in human, mouse, rat for ARHGEF5
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARHGEF5 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4