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ARHGEF5 Gene

protein-coding   GIFtS: 59
GCID: GC07P144052

Rho Guanine Nucleotide Exchange Factor (GEF) 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 51 2     GEF52
Guanine Nucleotide Regulatory Protein TIM1 2 3     P602
Transforming Immortalized Mammary Oncogene1 2 3     TIM12
TIM2 3 5     ephexin-32
Oncogene TIM2 3     Rho Guanine Nucleotide Exchange Factor 52
P60 TIM2 3     Ephexin-33

External Ids:    HGNC: 132091   Entrez Gene: 79842   Ensembl: ENSG000000503277   OMIM: 6008885   UniProtKB: Q127743   

Export aliases for ARHGEF5 gene to outside databases

Previous GC identifers: GC07P142309 GC07P143376 GC07P143454 GC07P143453 GC07P143428 GC07P143500 GC07P143683 GC07P138140


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGEF5 Gene:
Rho GTPases play a fundamental role in numerous cellular processes initiated by extracellular stimuli that work
through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate
Rho-dependent signals. This protein may be involved in the control of cytoskeletal organization. (provided by
RefSeq, Jul 2008)

GeneCards Summary for ARHGEF5 Gene:
ARHGEF5 (Rho guanine nucleotide exchange factor (GEF) 5) is a protein-coding gene. Diseases associated with ARHGEF5 include hepatocellular carcinoma, and adenocarcinoma. GO annotations related to this gene include GTP binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.

Gene Wiki entry for ARHGEF5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGEF5 gene promoter:
         AML1a   p53   NRSF form 1   XBP-1   NF-kappaB   NRSF form 2   c-Ets-1   FOXJ2 (long isoform)   NF-kappaB2   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): ARHGEF5 promoter sequence
   Search Chromatin IP Primers for ARHGEF5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q35   Ensembl cytogenetic band:  7q35   HGNC cytogenetic band: 7q35

ARHGEF5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF5 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P144052:  view genomic region     (about GC identifiers)

Start:
144,052,381 bp from pter      End:
144,077,725 bp from pter
Size:
25,345 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 143,390,747-143,415,984     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARHG5_HUMAN, Q12774 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 5  
Size: 1597 amino acids; 176799 Da
Sequence caution: Sequence=BAD18708.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A6NNJ2 Q6ZML7
Alternative splicing: 2 isoforms:  Q12774-1   Q12774-2   

Explore the universe of human proteins at neXtProt for ARHGEF5: NX_Q12774

Explore proteomics data for ARHGEF5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGEF5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005426.2  
    ENSEMBL proteins: 
     ENSP00000417979   ENSP00000056217   ENSP00000418745   ENSP00000418227  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGEF: Rho guanine nucleotide exchange factors

    5 InterPro protein domains:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom
     IPR001331 GDS_CDC24_CS

    Graphical View of Domain Structure for InterPro Entry Q12774

    ProtoNet protein and cluster: Q12774

    4 Blocks protein domains:
    IPB000219 DH domain
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like
    IPB011511 Variant SH3


    UniProtKB/Swiss-Prot: ARHG5_HUMAN, Q12774
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SH3 domain


    ARHGEF5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding IPI--
    GO:0005525GTP binding TAS8134109
         
    ARHGEF5 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGEF5:
     Decreased focal adhesion (FA)   Increased G1 DNA content 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Arhgef5):
     hematopoietic system  immune system  nervous system  no phenotypic analysis 

    ARHGEF5 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for ARHGEF5: Arhgef5tm1.2Meg Arhgef5tm1.1Dwu

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF5
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    miRNA
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    miRTarBase miRNAs that target ARHGEF5:
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    Block miRNA regulation of human, mouse, rat ARHGEF5 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate ARHGEF5:
    hsa-miR-130a* hsa-miR-23c hsa-miR-199a-5p hsa-miR-23b hsa-miR-199b-5p hsa-miR-330-3p hsa-miR-23a hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF5

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    nucleus3
    cytoskeleton1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane ----

    ARHGEF5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGEF5 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Pancreatic Adenocarcinoma0.59
    GPCR Pathway0.62
    Breast Cancer Regulation by Stathmin10.58
    2G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    Thrombin Signaling0.40
    G-AlphaI Signaling0.47
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    4fMLP Pathway
    CXCR4 Pathway0.39
    Internalin Pathway0.31
    5CREB Pathway
    Activation of PKC through GPCR0.63

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGEF5 (see all 21)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling

    1 BioSystems Pathway for ARHGEF5
        Regulation of RhoA activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGEF5
    Interactions:

        Search GeneGlobe Interaction Network for ARHGEF5

    STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

    Selected Interacting proteins for ARHGEF5 (Q127741, 2, 3 ENSP000000562174) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MED28Q9H2042, 3, ENSP000002373804MINT-7041853 I2D: score=1 STRING: ENSP00000237380
    SFNP319472, 3MINT-3974875 I2D: score=2 
    PLCG1P191743, ENSP000002440074I2D: score=2 STRING: ENSP00000244007
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    GRB2P629931, ENSP000003390074EBI-602199,EBI-401755 STRING: ENSP00000339007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002408myeloid dendritic cell chemotaxis IEA--
    GO:0030036actin cytoskeleton organization IEA--
    GO:0032319regulation of Rho GTPase activity IDA--
    GO:0032321positive regulation of Rho GTPase activity IEA--
    GO:0035023regulation of Rho protein signal transduction ----

    ARHGEF5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGEF5 (ARHG5)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARHGEF5 gene (2 alternative transcripts): 
    NM_005435.3  NM_001002861.1  

    Unigene Cluster for ARHGEF5:

    Rho guanine nucleotide exchange factor (GEF) 5
    Hs.334  [show with all ESTs]
    Unigene Representative Sequence: AK160365
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000498580 ENST00000056217(uc003wek.3 uc003wel.3) ENST00000474817
    ENST00000471847(uc003wem.3)
    miRNA
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    8 qRT-PCR Assays for microRNAs that regulate ARHGEF5:
    hsa-miR-130a* hsa-miR-23c hsa-miR-199a-5p hsa-miR-23b hsa-miR-199b-5p hsa-miR-330-3p hsa-miR-23a hsa-miR-1825
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF5 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF5
      QuantiFast Probe-based Assays in human, mouse, rat ARHGEF5

    Additional mRNA sequence: 

    AK090570.1 AK123596.1 AK160365.1 BC010046.2 BC011839.2 BC014555.2 BC136661.1 BX649178.1 
    CR749203.1 U02082.1 

    12 DOTS entries:

    DT.453361  DT.95088786  DT.100751897  DT.102835723  DT.91816105  DT.95373267  DT.91743124  DT.121037323 
    DT.102769  DT.102845469  DT.111011  DT.91763563 

    Selected AceView cDNA sequences (see all 176):

    AA704519 AI370486 AA502595 BM712072 AI650944 BG286254 C21270 AW663444 
    CD517373 BM670360 BE501425 AI521839 AI079550 BV178746 BQ953504 BI020419 
    AA595157 CB216819 BX334888 BG829821 BV168551 BM907830 BX097448 AI339573 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF5 (see all 11)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a ·
    SP1:                                                                                                        -                                   -               
    SP2:                                                                                                  -     -                                                   
    SP3:                                                                                                                                                            
    SP4:                    -                       -     -     -                                                                                                   
    SP5:                                      -                                                                                                                     

    ExUns: 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23
    SP1:                                            -                     
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                                  
    SP5:                                                                  


    ECgene alternative splicing isoforms for ARHGEF5

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGEF5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCAAGGGCTG
    ARHGEF5 Expression
    About this image

    ARHGEF5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGEF5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.334

    UniProtKB/Swiss-Prot: ARHG5_HUMAN, Q12774
    Tissue specificity: Mainly expressed in kidney, liver, pancreas, lung and placenta

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF5 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef51 , 5 Rho guanine nucleotide exchange factor (GEF) 51, 5 74.91(n)1
    66.69(a)1
      6 (21.15 cM)5
    543241  NM_133674.11  NP_598435.11 
     432655825 
    chicken
    (Gallus gallus)
    Aves ARHGEF56
    Rho guanine nucleotide exchange factor (GEF) 5
    70(a)
    1 ↔ 1
    1(74562445-74577343)
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF56
    Rho guanine nucleotide exchange factor (GEF) 5
    65(a)
    1 ↔ 1
    5(82113534-82159136)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.320052 Xenopus laevis transcribed sequence with weak similarity more 77.85(n)    CA793729.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ARHGEF56
    Rho guanine nucleotide exchange factor (GEF) 5
    24(a)
    1 ↔ 1
    16(19677195-19699399) ENSDARG00000076383
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH036933   -- 32(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea K07D4.7a3   -- 34(a)
    (best of 2)
      II(4004982-4015768)   --


    ENSEMBL Gene Tree for ARHGEF5 (if available)
    TreeFam Gene Tree for ARHGEF5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGEF5 gene
    ARHGEF192  ARHGEF152  ARHGEF162  NGEF2  ARHGEF262  
    7 SIMAP similar genes for ARHGEF5 using alignment to 5 protein entries:     ARHG5_HUMAN (see all proteins):
    ARHGEF35    LOC728377    DKFZp686N1969    SH3GL1    ARHGEF19    ARHGEF16
    NGEF

    ARHGEF5 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for ARHGEF5
    PGOHUM00000233061 PGOHUM00000250918


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGEF5 (see all 249)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2011767141,2
    C--144050932(+) GATCTA/GGAAAT 1 -- us2k10--------
    rs2022464831,2
    C--144050991(+) AAATAC/GGCAAG 1 -- us2k10--------
    rs712063401,2
    C--144051238(+) CTAAC-/AGAACA 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs26995121,2
    --144051922(-) TTGTTG/TTTTCT 1 -- us2k10--------
    rs624855161,2
    C--144051991(+) AACCAA/GTGAGG 1 -- us2k10--------
    rs1996429641,2
    F--144053995(+) GCCACG/ATTACA 1 -- int11Minor allele frequency- A:0.35EU 121
    rs2015142841,2
    C--144054503(+) ACACAC/TTGTAG 1 -- int10--------
    rs1457467771,2
    C--144054518(+) CAGTGA/GTCCAG 1 -- int10--------
    rs1997337311,2
    C--144054641(+) GATTTG/TTAAGT 1 -- int10--------
    rs1399349611,2
    C--144054681(+) AATCCA/GGGAAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for ARHGEF5 (144052381 - 144077725 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARHGEF5 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv24n31CNV Duplication19718026
    nsv471456CNV Duplication19718026
    nsv821609CNV Duplication20802225
    nsv819701CNV Insertion19587683
    nsv831177CNV Loss17160897
    dgv7527n71CNV Loss21882294
    nsv889377CNV Loss21882294
    nsv831175CNV Loss17160897
    dgv7525n71CNV Loss21882294
    dgv7526n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600888    OMIM disorders: --

    4 diseases for ARHGEF5:    
    About MalaCards
    hepatocellular carcinoma    adenocarcinoma    breast cancer    pancreatitis


    ARHGEF5 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGEF5
    Human Genome Epidemiology (HuGE) Navigator: ARHGEF5 (3 documents)

    Export disorders for ARHGEF5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGEF5 gene, integrated from 10 sources (see all 35):
    (articles sorted by number of sources associating them with ARHGEF5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Expression cDNA cloning of a novel oncogene with sequence similarity to regulators of small GTP-binding proteins. (PubMed id 8134109)1, 2, 3, 9 Chan A.M.-L.... Miki T. (Oncogene 1994)
    2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. Assignment of the human TIM proto-oncogene to 7q33--&gt;q35. (PubMed id 7656213)1, 3 Takai S....Miki T. (Cancer Genet. Cytogenet. 1995)
    6. Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases. (PubMed id 23359676)1 Cho W.H....Lee J.K. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    7. Identification of tumor antigens that elicit a humoral immune response in the sera of Chinese esophageal squamous cell carcinoma patients by modified serological proteome analysis. (PubMed id 24157810)1 Gao H....Zhao X. (Cancer Lett. 2013)
    8. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. (PubMed id 23535729)1 Michailidou K....Easton D.F. (Nat. Genet. 2013)
    9. Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics. (PubMed id 23956138)1 Foerster S....Ritter C.A. (Proteomics 2013)
    10. Exome sequencing reveals new causal mutations in children with epileptic encephalopathies. (PubMed id 23647072)1 Veeramah K.R....Hammer M.F. (Epilepsia 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7984 HGNC: 13209 AceView: OR2A7 Ensembl:ENSG00000050327 euGenes: HUgn7984
    ECgene: ARHGEF5 H-InvDB: ARHGEF5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGEF5 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARHGEF5 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGEF5 gene:
    Search GeneIP for patents involving ARHGEF5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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