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Aliases for ARHGEF40 Gene

Aliases for ARHGEF40 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 40 2 3
  • SOLO 3 4 6
  • Protein SOLO 3 4
  • Rho Guanine Nucleotide Exchange Factor 40 3
  • FLJ10357 6

External Ids for ARHGEF40 Gene

Previous GeneCards Identifiers for ARHGEF40 Gene

  • GC14P001659
  • GC14P021539

Summaries for ARHGEF40 Gene

Entrez Gene Summary for ARHGEF40 Gene

  • This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein contains in its C-terminus a GEF domain involved in exchange activity and a pleckstrin homology domain. Alternatively spliced transcripts that encode different proteins have been described. [provided by RefSeq, Mar 2014]

GeneCards Summary for ARHGEF40 Gene

ARHGEF40 (Rho Guanine Nucleotide Exchange Factor (GEF) 40) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is TRIO.

UniProtKB/Swiss-Prot for ARHGEF40 Gene

  • May act as a guanine nucleotide exchange factor (GEF).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF40 Gene

Genomics for ARHGEF40 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for ARHGEF40 Gene

21,070,260 bp from pter
21,090,248 bp from pter
19,989 bases
Plus strand

Genomic View for ARHGEF40 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF40 Gene

No data available for Regulatory Elements for ARHGEF40 Gene

Proteins for ARHGEF40 Gene

  • Protein details for ARHGEF40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 40
    Protein Accession:
    Secondary Accessions:
    • A5PL07
    • Q9BWP5
    • Q9H7L6
    • Q9NTF9
    • Q9NW24

    Protein attributes for ARHGEF40 Gene

    1519 amino acids
    Molecular mass:
    164658 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91563.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15753.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB84883.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF40 Gene


neXtProt entry for ARHGEF40 Gene

Proteomics data for ARHGEF40 Gene at MOPED

Post-translational modifications for ARHGEF40 Gene

  • Ubiquitination at Lys56 and Lys189
  • Modification sites at PhosphoSitePlus

Other Protein References for ARHGEF40 Gene

No data available for DME Specific Peptides for ARHGEF40 Gene

Domains for ARHGEF40 Gene

Gene Families for ARHGEF40 Gene

  • ARHGEF :Rho guanine nucleotide exchange factors

Protein Domains for ARHGEF40 Gene

Suggested Antigen Peptide Sequences for ARHGEF40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q8TER5
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with ARHGEF40: view

Function for ARHGEF40 Gene

Molecular function for ARHGEF40 Gene

UniProtKB/Swiss-Prot Function: May act as a guanine nucleotide exchange factor (GEF).

Gene Ontology (GO) - Molecular Function for ARHGEF40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARHGEF40: view

Phenotypes for ARHGEF40 Gene

GenomeRNAi human phenotypes for ARHGEF40:
genes like me logo Genes that share phenotypes with ARHGEF40: view

Animal Model Products

CRISPR Products

miRNA for ARHGEF40 Gene

miRTarBase miRNAs that target ARHGEF40

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGEF40 Gene

Localization for ARHGEF40 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF40 Gene

Cytoplasm. Note=Concentrated in the perinuclear region.

Subcellular locations from

Jensen Localization Image for ARHGEF40 Gene COMPARTMENTS Subcellular localization image for ARHGEF40 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ARHGEF40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARHGEF40: view

Pathways for ARHGEF40 Gene

SuperPathways for ARHGEF40 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARHGEF40 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGEF40: view

No data available for Pathways by source for ARHGEF40 Gene

Transcripts for ARHGEF40 Gene

Unigene Clusters for ARHGEF40 Gene

Rho guanine nucleotide exchange factor (GEF) 40:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGEF40

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARHGEF40

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF40 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a ·
SP1: - - - - - -
SP2: -
SP3: -

ExUns: 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for ARHGEF40 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGEF40 Gene

mRNA expression in normal human tissues for ARHGEF40 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARHGEF40 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF40 Gene Hs.35125

mRNA Expression by UniProt/SwissProt for ARHGEF40 Gene

Tissue specificity: Expressed at higher level in the central nervous system and skeletal muscle and greater abundance in fetal than adult brain (at protein level).
genes like me logo Genes that share expressions with ARHGEF40: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARHGEF40 Gene

Orthologs for ARHGEF40 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF40 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGEF40 35
  • 98.38 (n)
  • 97.53 (a)
  • 98 (a)
(Bos Taurus)
Mammalia ARHGEF40 35
  • 88.68 (n)
  • 89.85 (a)
  • 90 (a)
(Canis familiaris)
Mammalia ARHGEF40 35
  • 87.07 (n)
  • 88.06 (a)
  • 82 (a)
(Mus musculus)
Mammalia Arhgef40 35
  • 85.01 (n)
  • 86.59 (a)
Arhgef40 16
Arhgef40 36
  • 86 (a)
(Monodelphis domestica)
Mammalia ARHGEF40 36
  • 76 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
-- 36
  • 67 (a)
(Rattus norvegicus)
Mammalia Arhgef40 35
  • 84.69 (n)
  • 86.38 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1577 35
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100498627 35
  • 51.58 (n)
  • 45.35 (a)
(Danio rerio)
Actinopterygii ARHGEF40 36
  • 25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG30456 36
  • 16 (a)
CG33275 36
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 32 (a)
Species with no ortholog for ARHGEF40:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF40 Gene

Gene Tree for ARHGEF40 (if available)
Gene Tree for ARHGEF40 (if available)

Paralogs for ARHGEF40 Gene

Paralogs for ARHGEF40 Gene

Selected SIMAP similar genes for ARHGEF40 Gene using alignment to 4 proteins: Pseudogenes for ARHGEF40 Gene

genes like me logo Genes that share paralogs with ARHGEF40: view

Variants for ARHGEF40 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF40 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs749731 -- 21,084,845(+) CTCTT(C/T)GAGCA reference, synonymous-codon
rs943992 - 21,084,898(+) AGAGA(C/T)GTTTG missense, reference
rs1243472 -- 21,074,594(+) CGGGC(A/G)TGGAT utr-variant-5-prime, synonymous-codon, reference
rs1243473 -- 21,076,115(+) CTTAA(C/T)TTTCC intron-variant
rs1958395 -- 21,082,899(+) GCTGC(A/G)CTCAG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF40 Gene

Variant ID Type Subtype PubMed ID
nsv832740 CNV Gain 17160897
nsv826882 CNV Gain 20364138
dgv123n21 CNV Loss 19592680

Relevant External Links for ARHGEF40 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF40 Gene

Disorders for ARHGEF40 Gene

No disorders were found for ARHGEF40 Gene.

No data available for UniProtKB/Swiss-Prot for ARHGEF40 Gene

Publications for ARHGEF40 Gene

  1. Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain. (PMID: 16143467) Tse S.-W. … Andreadis A. (Gene 2005) 2 3 4 23
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3
  4. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for ARHGEF40 Gene

Sources for ARHGEF40 Gene

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