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ARHGEF40 Gene

protein-coding   GIFtS: 50
GCID: GC14P021539

Rho Guanine Nucleotide Exchange Factor (GEF) 40

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 401 2
SOLO2 3 5
Protein SOLO2 3
Rho Guanine Nucleotide Exchange Factor 402
FLJ103575

External Ids:    HGNC: 255161   Entrez Gene: 557012   Ensembl: ENSG000001658017   OMIM: 6100185   UniProtKB: Q8TER53   

Export aliases for ARHGEF40 gene to outside databases

Previous GC identifer: GC14P001659


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGEF40 Gene:
This gene encodes a protein similar to guanosine nucleotide exchange factors for Rho GTPases. The encoded protein
contains in its C-terminus a GEF domain involved in exchange activity and a pleckstrin homology domain.
Alternatively spliced transcripts that encode different proteins have been described. (provided by RefSeq, Mar
2014)

GeneCards Summary for ARHGEF40 Gene:
ARHGEF40 (Rho guanine nucleotide exchange factor (GEF) 40) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is KALRN.

UniProtKB/Swiss-Prot: ARH40_HUMAN, Q8TER5
Function: May act as a guanine nucleotide exchange factor (GEF) (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ARHGEF40
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF40 promoter sequence
   Search Chromatin IP Primers for ARHGEF40

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF40


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

ARHGEF40 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF40 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P021539:  view genomic region     (about GC identifiers)

Start:
21,538,429 bp from pter      End:
21,558,399 bp from pter
Size:
19,971 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARH40_HUMAN, Q8TER5 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 40  
Size: 1519 amino acids; 164658 Da
Sequence caution: Sequence=BAA91563.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15753.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAB84883.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A5PL07 Q9BWP5 Q9H7L6 Q9NTF9 Q9NW24
Alternative splicing: 4 isoforms:  Q8TER5-1   Q8TER5-2   Q8TER5-3   Q8TER5-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGEF40: NX_Q8TER5

Explore proteomics data for ARHGEF40 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys56, Lys189
  • Modification sites at PhosphoSitePlus

  • See ARHGEF40 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001265458.1  NP_001265459.1  NP_060541.3  

    ENSEMBL proteins: 
     ENSP00000298694   ENSP00000451335   ENSP00000451655   ENSP00000452283   ENSP00000298693  

    ARHGEF40 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ARHGEF40

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGEF: Rho guanine nucleotide exchange factors

    3 InterPro protein domains:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q8TER5

    ProtoNet protein and cluster: Q8TER5

    2 Blocks protein domains:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARH40_HUMAN, Q8TER5
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain


    Find genes that share domains with ARHGEF40           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARH40_HUMAN, Q8TER5
    Function: May act as a guanine nucleotide exchange factor (GEF) (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
         
    Find genes that share ontologies with ARHGEF40           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGEF40:
     Increased HPV18 LCR reporter a  Increased cell number in G2M,  

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for ARHGEF40

    miRNA
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    miRTarBase miRNAs that target ARHGEF40:
    hsa-mir-215-5p (MIRT024801), hsa-mir-192-5p (MIRT026863)

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    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF40 (see all 17):
    hsa-miR-142-5p hsa-miR-448 hsa-miR-374a hsa-miR-132 hsa-miR-340 hsa-miR-124 hsa-miR-889 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF40 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARH40_HUMAN, Q8TER5: Cytoplasm. Note=Concentrated in the perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with ARHGEF40           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGEF40
    Interactions:

        Search GeneGlobe Interaction Network for ARHGEF40

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for ARHGEF40 (Q8TER52, 3 ENSP000002986944) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MYCBPQ994172, 3, ENSP000003807024MINT-65269 I2D: score=5 STRING: ENSP00000380702
    STC2O760612, 3MINT-65648 I2D: score=5 
    TAC1P203662, 3, ENSP000003211064MINT-63551 I2D: score=4 STRING: ENSP00000321106
    MAPTENSP000003408204STRING: ENSP00000340820
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035023regulation of Rho protein signal transduction ----

    Find genes that share ontologies with ARHGEF40           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGEF40 (ARH40)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGEF40 gene (3 alternative transcripts): 
    NM_001278529.1  NM_001278530.1  NM_018071.4  

    Unigene Cluster for ARHGEF40:

    Rho guanine nucleotide exchange factor (GEF) 40
    Hs.35125  [show with all ESTs]
    Unigene Representative Sequence: NM_018071
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298694(uc001vzp.3 uc010aij.3) ENST00000555038(uc001vzn.1)
    ENST00000556399 ENST00000553709 ENST00000555232(uc001vzo.1) ENST00000555052
    ENST00000554514 ENST00000557498 ENST00000298693(uc010tln.2)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF40 (see all 17):
    hsa-miR-142-5p hsa-miR-448 hsa-miR-374a hsa-miR-132 hsa-miR-340 hsa-miR-124 hsa-miR-889 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF40 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AK001219.1 AK024463.1 AK074057.1 AK126755.1 AL137291.1 BC000084.2 BC009992.2 BC142692.1 
    BC144317.1 BC151212.1 BX248768.1 

    11 DOTS entries:

    DT.453832  DT.211689  DT.40269107  DT.100780444  DT.100780446  DT.100724771  DT.101962084  DT.95323803 
    DT.207630  DT.91854118  DT.97777468 

    Selected AceView cDNA sequences (see all 232):

    AI640434 AW024354 BU931982 AW008931 BU581209 BE858257 AI201690 NM_018071 
    AI190961 BQ026439 BU553955 BM994640 CA841074 BQ576261 CR618390 BM509413 
    AI218228 AI446011 BM509169 AI858735 AA345181 AI075775 BU173987 AI619459 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF40 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16a · 16b ^ 17a · 17b ^ 18 ^ 19a ·
    SP1:                    -     -     -     -     -     -                                                                                                         
    SP2:                                                                                                                                      -                     
    SP3:                                                                                                                                      -                     
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19b ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24a · 24b
    SP1:                                                
    SP2:  -           -                                 
    SP3:  -           -     -                           
    SP4:  -                                             
    SP5:                                                


    ECgene alternative splicing isoforms for ARHGEF40

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGEF40 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGEF40 Expression
    About this image

    ARHGEF40 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGEF40 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.35125

    UniProtKB/Swiss-Prot: ARH40_HUMAN, Q8TER5
    Tissue specificity: Expressed at higher level in the central nervous system and skeletal muscle and greater
    abundance in fetal than adult brain (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF40

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF40 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef401 , 5 Rho guanine nucleotide exchange factor (GEF) 401, 5 85.01(n)1
    86.59(a)1
      14 (26.75 cM)5
    2687391  NM_198249.41  NP_937892.21 
     519847195 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.15772 Xenopus laevis transcribed sequence 84.12(n)    BG347016.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ARHGEF406
    Rho guanine nucleotide exchange factor (GEF) 40
    25(a)
    1 ↔ 1
    7(76490268-76572963) ENSDARG00000078979
    fruit fly
    (Drosophila melanogaster)
    Insecta CG332756
    CG304566
    --
    16(a)
    16(a)
    many ↔ many
    many ↔ many
    3L(7586191-7632673)
    2R(12987746-12995047)


    ENSEMBL Gene Tree for ARHGEF40 (if available)
    TreeFam Gene Tree for ARHGEF40 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGEF40 gene
    KALRN2  ARHGEF252  MCF2L22  PLEKHG4B2  TRIO2  MCF2L2  KIAA17552  PLEKHG42  
    MCF22  
    1 SIMAP similar gene for ARHGEF40 using alignment to 4 protein entries:     ARH40_HUMAN (see all proteins):
    FLJ10357

    Find genes that share paralogs with ARHGEF40           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for ARHGEF40
    PGOHUM00000235495


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGEF40 (see all 646)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1512447611,2
    C--21536865(+) GCCGGG/TTGTTA 1 -- us2k10--------
    rs19525111,2
    C,F,H--21536875(+) AGAAAG/AAGCTC 1 -- us2k118Minor allele frequency- A:0.08NS EA NA WA CSA 1820
    rs1917001201,2
    --21536951(+) TGACGC/TATGGA 1 -- us2k10--------
    rs1831562411,2
    --21536967(+) GGCCTC/TTTCTT 1 -- us2k10--------
    rs611847521,2
    C,F--21537062(+) GGTGAG/AAGAAG 1 -- us2k13Minor allele frequency- A:0.15WA CSA 122
    rs1392697151,2
    --21537081(+) ACCTTA/GGCGGC 1 -- us2k10--------
    rs9439901,2
    C,F,A,H--21537087(+) GCGGCG/ACCCCC 1 -- us2k114Minor allele frequency- A:0.18NA WA CSA EA 380
    rs1153926201,2
    C,F--21537090(+) GCACCC/TCCGCC 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs619781951,2
    C,F--21537125(+) GCCCAG/CAGGCT 1 -- us2k14Minor allele frequency- C:0.05WA NA CSA EA 126
    rs1880369361,2
    --21537198(+) GGGCAC/TACGCG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGEF40 (21538429 - 21558399 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ARHGEF40:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv123n21CNV Loss19592680
    nsv832740CNV Gain17160897
    nsv826882CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610018    OMIM disorders: --


    Find genes that share disorders with ARHGEF40           About GenesLikeMe


    Export disorders for ARHGEF40 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGEF40 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with ARHGEF40)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification, expression analysis, genomic organization and cellular location of a novel protein with a RhoGEF domain. (PubMed id 16143467)1, 2, 3, 9 Tse S.-W.... Andreadis A. (Gene 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    7. Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels. (PubMed id 21987572)1 Lee K.A....Doedens J.R. (J. Biol. Chem. 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55701 HGNC: 25516 AceView: FLJ10357 Ensembl:ENSG00000165801 euGenes: HUgn55701
    ECgene: ARHGEF40 H-InvDB: ARHGEF40

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGEF40 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGEF40 gene:
    Search GeneIP for patents involving ARHGEF40

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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