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Aliases for ARHGEF39 Gene

Aliases for ARHGEF39 Gene

  • Rho Guanine Nucleotide Exchange Factor 39 2 3 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 39 2 3
  • C9orf100 3 4
  • Chromosome 9 Open Reading Frame 100 2
  • Vav-Like Protein C9orf100 3

External Ids for ARHGEF39 Gene

Previous HGNC Symbols for ARHGEF39 Gene

  • C9orf100

Summaries for ARHGEF39 Gene

GeneCards Summary for ARHGEF39 Gene

ARHGEF39 (Rho Guanine Nucleotide Exchange Factor 39) is a Protein Coding gene. Diseases associated with ARHGEF39 include hepatocellular carcinoma. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for ARHGEF39 Gene

  • Promotes cell proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF39 Gene

Genomics for ARHGEF39 Gene

Regulatory Elements for ARHGEF39 Gene

Promoters for ARHGEF39 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGEF39 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGEF39 Gene

Chromosome:
9
Start:
35,658,875 bp from pter
End:
35,675,866 bp from pter
Size:
16,992 bases
Orientation:
Minus strand

Genomic View for ARHGEF39 Gene

Genes around ARHGEF39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF39 Gene

Proteins for ARHGEF39 Gene

  • Protein details for ARHGEF39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4T4-ARG39_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 39
    Protein Accession:
    Q8N4T4
    Secondary Accessions:
    • Q49AG0
    • Q6TPQ2
    • Q96ST6

    Protein attributes for ARHGEF39 Gene

    Size:
    335 amino acids
    Molecular mass:
    38295 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAR01010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAR01011.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF39 Gene

Proteomics data for ARHGEF39 Gene at MOPED

Post-translational modifications for ARHGEF39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF39 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF39 Gene

Domains & Families for ARHGEF39 Gene

Protein Domains for ARHGEF39 Gene

Suggested Antigen Peptide Sequences for ARHGEF39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N4T4

UniProtKB/Swiss-Prot:

ARG39_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with ARHGEF39: view

No data available for Gene Families for ARHGEF39 Gene

Function for ARHGEF39 Gene

Molecular function for ARHGEF39 Gene

UniProtKB/Swiss-Prot Function:
Promotes cell proliferation.

Gene Ontology (GO) - Molecular Function for ARHGEF39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with ARHGEF39: view
genes like me logo Genes that share phenotypes with ARHGEF39: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF39 Gene

Localization for ARHGEF39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF39 Gene

Cell membrane.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF39 Gene COMPARTMENTS Subcellular localization image for ARHGEF39 gene
Compartment Confidence
plasma membrane 5
cytosol 2
nucleus 2
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for ARHGEF39 Gene

Pathways & Interactions for ARHGEF39 Gene

SuperPathways for ARHGEF39 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARHGEF39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGEF39: view

No data available for Pathways by source and SIGNOR curated interactions for ARHGEF39 Gene

Drugs & Compounds for ARHGEF39 Gene

(3) Drugs for ARHGEF39 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGEF39: view

Transcripts for ARHGEF39 Gene

Unigene Clusters for ARHGEF39 Gene

Rho guanine nucleotide exchange factor (GEF) 39:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF39 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: - - - - -
SP6:
SP7: -

Relevant External Links for ARHGEF39 Gene

GeneLoc Exon Structure for
ARHGEF39
ECgene alternative splicing isoforms for
ARHGEF39

Expression for ARHGEF39 Gene

mRNA expression in normal human tissues for ARHGEF39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGEF39 Gene

This gene is overexpressed in Frontal cortex (44.6), NK cells (13.8), and Fetal gut (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ARHGEF39 Gene



SOURCE GeneReport for Unigene cluster for ARHGEF39 Gene Hs.534579

mRNA Expression by UniProt/SwissProt for ARHGEF39 Gene

Q8N4T4-ARG39_HUMAN
Tissue specificity: Strongly expressed in hepatocellular carcinoma (HCC) compared with their non-cancerous counterparts.
genes like me logo Genes that share expression patterns with ARHGEF39: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein tissue co-expression partners for ARHGEF39 Gene

Orthologs for ARHGEF39 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF39 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGEF39 35
  • 88.96 (n)
  • 89.85 (a)
ARHGEF39 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF39 35
  • 87.66 (n)
  • 87.76 (a)
ARHGEF39 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef39 35
  • 85.47 (n)
  • 86.57 (a)
Arhgef39 16
Arhgef39 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF39 35
  • 99.7 (n)
  • 99.7 (a)
ARHGEF39 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef39 35
  • 86.81 (n)
  • 88.34 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF39 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF39 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CZH9ORF100 35
  • 61.22 (n)
  • 57.86 (a)
CZH9ORF100 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF39 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485947 35
  • 52.56 (n)
  • 43.57 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgef39 35
  • 56.79 (n)
  • 50.62 (a)
arhgef39 36
  • 39 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011707 35
  • 43.62 (n)
  • 27.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGEF4 35
  • 43.62 (n)
  • 26.17 (a)
Species with no ortholog for ARHGEF39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF39 Gene

ENSEMBL:
Gene Tree for ARHGEF39 (if available)
TreeFam:
Gene Tree for ARHGEF39 (if available)

Paralogs for ARHGEF39 Gene

No data available for Paralogs for ARHGEF39 Gene

Variants for ARHGEF39 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF39 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs2297879 - 35,662,254(-) CCCTC(A/G)TGAGA nc-transcript-variant, downstream-variant-500B, reference, missense, utr-variant-3-prime
rs45567235 - 35,665,156(+) CGGGG(A/C)AGGAG intron-variant, nc-transcript-variant, reference, missense
rs1538536 -- 35,665,801(-) CTGGC(A/C)ACAGA intron-variant, upstream-variant-2KB
rs1934158 -- 35,671,630(+) CTCTT(G/T)TAGTT intron-variant
rs1361338 -- 35,664,627(-) CCCAG(A/C/G/T)GCCTT intron-variant

Variation tolerance for ARHGEF39 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.42; 88.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF39 Gene

HapMap Linkage Disequilibrium report
ARHGEF39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARHGEF39 Gene

Disorders for ARHGEF39 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGEF39 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hepatocellular carcinoma, somatic
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGEF39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF39
genes like me logo Genes that share disorders with ARHGEF39: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGEF39 Gene

Publications for ARHGEF39 Gene

  1. C9orf100, a new member of the Dbl-family guanine nucleotide exchange factors, promotes cell proliferation and migration in hepatocellular carcinoma. (PMID: 22327280) Wang H. … Cai B. (Mol. Med. Report. 2012) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3

Products for ARHGEF39 Gene

Sources for ARHGEF39 Gene

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