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Aliases for ARHGEF39 Gene

Aliases for ARHGEF39 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 39 2 3
  • C9orf100 3 4
  • Rho Guanine Nucleotide Exchange Factor 39 3
  • Chromosome 9 Open Reading Frame 100 2
  • Vav-Like Protein C9orf100 3

External Ids for ARHGEF39 Gene

Previous HGNC Symbols for ARHGEF39 Gene

  • C9orf100

Summaries for ARHGEF39 Gene

GeneCards Summary for ARHGEF39 Gene

ARHGEF39 (Rho Guanine Nucleotide Exchange Factor (GEF) 39) is a Protein Coding gene. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for ARHGEF39 Gene

  • Promotes cell proliferation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF39 Gene

Genomics for ARHGEF39 Gene

Genomic Location for ARHGEF39 Gene

Start:
35,658,875 bp from pter
End:
35,675,866 bp from pter
Size:
16,992 bases
Orientation:
Minus strand

Genomic View for ARHGEF39 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF39 Gene

No data available for Regulatory Elements for ARHGEF39 Gene

Proteins for ARHGEF39 Gene

  • Protein details for ARHGEF39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N4T4-ARG39_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 39
    Protein Accession:
    Q8N4T4
    Secondary Accessions:
    • Q49AG0
    • Q6TPQ2
    • Q96ST6

    Protein attributes for ARHGEF39 Gene

    Size:
    335 amino acids
    Molecular mass:
    38295 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAR01010.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAR01011.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF39 Gene

Proteomics data for ARHGEF39 Gene at MOPED

Post-translational modifications for ARHGEF39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF39 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF39 Gene

Domains for ARHGEF39 Gene

Protein Domains for ARHGEF39 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N4T4

UniProtKB/Swiss-Prot:

ARG39_HUMAN :
  • Q8N4T4
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with ARHGEF39: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ARHGEF39 Gene

Function for ARHGEF39 Gene

Molecular function for ARHGEF39 Gene

UniProtKB/Swiss-Prot Function: Promotes cell proliferation.

Gene Ontology (GO) - Molecular Function for ARHGEF39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARHGEF39: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGEF39 Gene

Localization for ARHGEF39 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF39 Gene

Cell membrane.

Gene Ontology (GO) - Cellular Components for ARHGEF39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 22327280
genes like me logo Genes that share ontologies with ARHGEF39: view

No data available for Subcellular locations from COMPARTMENTS for ARHGEF39 Gene

Pathways for ARHGEF39 Gene

SuperPathways for ARHGEF39 Gene

No Data Available

Gene Ontology (GO) - Biological Process for ARHGEF39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030335 positive regulation of cell migration IDA 22327280
GO:0035023 regulation of Rho protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGEF39: view

No data available for Pathways by source for ARHGEF39 Gene

Transcripts for ARHGEF39 Gene

Unigene Clusters for ARHGEF39 Gene

Rho guanine nucleotide exchange factor (GEF) 39:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF39 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - -
SP2: - -
SP3: - - - - -
SP4: -
SP5: - - - - -
SP6:
SP7: -

Relevant External Links for ARHGEF39 Gene

GeneLoc Exon Structure for
ARHGEF39
ECgene alternative splicing isoforms for
ARHGEF39

Expression for ARHGEF39 Gene

mRNA expression in normal human tissues for ARHGEF39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARHGEF39 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF39 Gene Hs.534579

mRNA Expression by UniProt/SwissProt for ARHGEF39 Gene

Q8N4T4-ARG39_HUMAN
Tissue specificity: Strongly expressed in hepatocellular carcinoma (HCC) compared with their non-cancerous counterparts.
genes like me logo Genes that share expressions with ARHGEF39: view

No data available for mRNA differential expression in normal tissues for ARHGEF39 Gene

Orthologs for ARHGEF39 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF39 35
  • 99.7 (n)
  • 99.7 (a)
ARHGEF39 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGEF39 35
  • 88.96 (n)
  • 89.85 (a)
ARHGEF39 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF39 35
  • 87.66 (n)
  • 87.76 (a)
ARHGEF39 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef39 35
  • 85.47 (n)
  • 86.57 (a)
Arhgef39 16
Arhgef39 36
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF39 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF39 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef39 35
  • 86.81 (n)
  • 88.34 (a)
chicken
(Gallus gallus)
Aves CZH9ORF100 35
  • 61.22 (n)
  • 57.86 (a)
CZH9ORF100 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF39 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485947 35
  • 52.56 (n)
  • 43.57 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgef39 35
  • 56.79 (n)
  • 50.62 (a)
arhgef39 36
  • 39 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011707 35
  • 43.62 (n)
  • 27.14 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGEF4 35
  • 43.62 (n)
  • 26.17 (a)
Species with no ortholog for ARHGEF39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF39 Gene

ENSEMBL:
Gene Tree for ARHGEF39 (if available)
TreeFam:
Gene Tree for ARHGEF39 (if available)

Paralogs for ARHGEF39 Gene

No data available for Paralogs for ARHGEF39 Gene

Variants for ARHGEF39 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF39 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1361338 -- 35,664,627(-) CCCAG(A/C/G/T)GCCTT intron-variant
rs1538536 -- 35,665,801(-) CTGGC(A/C)ACAGA upstream-variant-2KB, intron-variant
rs1934158 -- 35,671,630(+) CTCTT(G/T)TAGTT intron-variant
rs2297879 - 35,662,254(-) CCCTC(A/G)TGAGA reference, missense, nc-transcript-variant
rs4878623 -- 35,667,064(+) AGGTC(A/G)GGAGT upstream-variant-2KB, intron-variant

Relevant External Links for ARHGEF39 Gene

HapMap Linkage Disequilibrium report
ARHGEF39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARHGEF39 Gene

Disorders for ARHGEF39 Gene

No disorders were found for ARHGEF39 Gene.

No data available for UniProtKB/Swiss-Prot for ARHGEF39 Gene

Publications for ARHGEF39 Gene

  1. C9orf100, a new member of the Dbl-family guanine nucleotide exchange factors, promotes cell proliferation and migration in hepatocellular carcinoma. (PMID: 22327280) Wang H. … Cai B. (Mol. Med. Report. 2012) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for ARHGEF39 Gene

Sources for ARHGEF39 Gene

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