ARHGEF38 Gene
protein-coding GIFtS: 39
GCID: GC04P106474
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Rho guanine nucleotide exchange factor (GEF) 38
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Aliases
for ARHGEF38 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho Guanine Nucleotide Exchange Factor (GEF) 381 2 | | FLJ201841 | | Rho Guanine Nucleotide Exchange Factor 382 |
Export aliases for ARHGEF38 gene to outside databasesPrevious GC identifer: GC04P102208 |
Summaries
for ARHGEF38 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ARH38_HUMAN, Q9NXL2Function: May act as a guanine-nucleotide releasing factor (By similarity)
|
Genomic Views
for ARHGEF38 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ARHGEF38
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGEF38
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF38 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q24 Ensembl cytogenetic band: 4q24 HGNC cytogenetic band: 4q24ARHGEF38 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P106474: view genomic region
(about GC identifiers)
Start:
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106,473,777 bp from pter |
End:
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106,616,835 bp from pter |
Size:
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143,059 bases |
Orientation:
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plus strand |
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Proteins
for ARHGEF38 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARH38_HUMAN, Q9NXL2 (See
protein sequence)Recommended Name: Rho guanine nucleotide exchange factor 38 Size: 219 amino acids; 25507 DaExplore the universe of human proteins at neXtProt for ARHGEF38: NX_Q9NXL2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NXL2
ARHGEF38 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001229658.1 NP_060170.1
ENSEMBL proteins: ENSP00000265154 ENSP00000416125
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ARHGEF38 for ontologies About GeneDecksing
ARHGEF38 Antibody Products:
Assay Products for ARHGEF38: |
Protein
Domains /
Families
for ARHGEF38 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGEF38 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NXL2ProtoNet protein and cluster: Q9NXL2 UniProtKB/Swiss-Prot: ARH38_HUMAN, Q9NXL2Similarity: Contains 1 DH (DBL-homology) domain |
Function
for ARHGEF38 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARH38_HUMAN, Q9NXL2Function: May act as a guanine-nucleotide releasing factor (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF38
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF38
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARHGEF38 (NM_017700) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF38 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF38 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF38 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
IEA | -- |
ARHGEF38 for ontologies About GeneDecksing
|
Pathways & Interactions
for ARHGEF38 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGEF38
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035023 | regulation of Rho protein signal transduction |
IEA | -- |
ARHGEF38 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGEF38 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARHGEF38
Search CenterWatch for drugs/clinical trials and news about ARHGEF38 / ARH38
|
Transcripts
for ARHGEF38 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGEF38 gene (2 alternative transcripts): NM_001242729.1 NM_017700.1 Unigene Clusters for ARHGEF38: Rho guanine nucleotide exchange factor (GEF) 38 Hs.585224 [show with all ESTs], Hs.744739 Unigene Representative Sequences: NM_001242729, AK1259515 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000265154(uc003hxu.3) ENST00000420470(uc003hxv.2) ENST00000506828
ENST00000508036 ENST00000503289
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF38
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF38
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARHGEF38 (NM_017700) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF38 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF38 |
Additional cDNA sequence: AK125951.1 2 DOTS entries: DT.97833707 DT.70104064 7 AceView cDNA sequences: NM_017700 AK000191 BM764428 BM765867 BX646643 BM745286 BQ325238
GeneLoc Exon Structure
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Expression
for ARHGEF38 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGEF38 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTTCCTTTC
About this image
See ARHGEF38 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGEF38
SOURCE GeneReport for Unigene clusters: Hs.585224 Hs.744739
SABiosciences Custom PCR Arrays for ARHGEF38
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF38
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF38 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF38 |
Orthologs
for ARHGEF38 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGEF38 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for ARHGEF38 (if available)
TreeFam Gene Tree for ARHGEF38 (if available) |
Paralogs
for ARHGEF38 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGEF38 gene
- DNMBP2 ARHGEF372
3 SIMAP similar genes for ARHGEF38 using alignment to 2 protein entries: ARH38_HUMAN (see all proteins):ARHGEF37 DNMBP PREX2
ARHGEF38 for paralogs About GeneDecksing
|
Genomic Variants
for ARHGEF38 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
| | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF38 |
|
Disorders
/ Diseases
for ARHGEF38 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGEF38 for disorders About GeneDecksing
4  diseases for ARHGEF38: About MalaCardspulmonary function alcohol dependence spasticity alcoholism
Human Genome Epidemiology (HuGE) Navigator: ARHGEF38 (0 documents)
Export disorders for ARHGEF38 gene to outside databases
|
Publications
for ARHGEF38 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGEF38 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARHGEF38) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1 Takefuji M....Kaibuchi K. (2010)
- A systematic gene-based screen of chr4q22-q32 identif ies association of a novel susceptibility gene, DKK2, with the quantitative tra it of alcohol dependence symptom counts. (PubMed id 20332099)1 Kalsi G....Riley B.P. (2010)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Meta-analyses of genome-wide association studies iden tify multiple loci associated with pulmonary function. (PubMed id 20010835)1 Hancock D.B....London S.J. (2010)
- Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)1 Uhl G.R....Lerman C. (2008)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for ARHGEF38 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ARHGEF38 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGEF38 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARHGEF38 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARHGEF38 | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ARHGEF38 gene:
Search GeneIP for patents involving ARHGEF38
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARHGEF38 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARHGEF38 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF38 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF38 | | | OriGene Protein Over-expression Lysate for ARHGEF38 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARHGEF38 | | OriGene 3'-UTR Clone for ARHGEF38 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF38 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF38 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ARHGEF38 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGEF38 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF38 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF38 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF38 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF38 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF38 |
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 | | | ARHGEF38 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF38 |
|  |  |  | | | | Search ThermoFisher Antibodies for ARHGEF38 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF38 |
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