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Aliases for ARHGEF38 Gene

Aliases for ARHGEF38 Gene

  • Rho Guanine Nucleotide Exchange Factor 38 2 3 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 38 2

External Ids for ARHGEF38 Gene

Previous GeneCards Identifiers for ARHGEF38 Gene

  • GC04P106474
  • GC04P102208

Summaries for ARHGEF38 Gene

GeneCards Summary for ARHGEF38 Gene

ARHGEF38 (Rho Guanine Nucleotide Exchange Factor 38) is a Protein Coding gene. Among its related pathways are p75 NTR receptor-mediated signalling and RET signaling. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DNMBP.

UniProtKB/Swiss-Prot for ARHGEF38 Gene

  • May act as a guanine-nucleotide releasing factor.

Additional gene information for ARHGEF38 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF38 Gene

Genomics for ARHGEF38 Gene

Regulatory Elements for ARHGEF38 Gene

Enhancers for ARHGEF38 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H105593 1.1 ENCODE dbSUPER 18.8 +41.8 41767 2 FOXA2 PKNOX1 TBL1XR1 NFIB BMI1 BATF RAD21 YY1 FOS ATF7 ARHGEF38 LOC105377352 INTS12 ENSG00000248778 ARHGEF38-IT1
GH04H105585 1.1 ENCODE dbSUPER 11.3 +33.7 33674 2 SOX13 FOXA2 FEZF1 ZNF384 CEBPG RAD21 YY1 CTBP1 GATA3 FOS ARHGEF38 LOC105377352 INTS12 PPA2 ARHGEF38-IT1 ENSG00000248778
GH04H105624 1.1 Ensembl ENCODE dbSUPER 10.8 +72.3 72329 1 EED IKZF1 HNF4A IKZF2 RAD21 SPI1 YY1 ARHGEF38 LOC105377352 ENSG00000248778 ARHGEF38-IT1
GH04H105637 0.9 Ensembl dbSUPER 10.8 +85.2 85179 0 ZNF132 NFIB HLF ZNF195 FEZF1 YY1 LCORL NFIC ZNF350 ZNF300 GSTCD LOC101929577 TBCK LOC105377352 ARHGEF38 AIMP1 ENSG00000248778 ARHGEF38-IT1
GH04H105605 0.6 dbSUPER 10.7 +53.1 53122 1 JUNB BMI1 DPF2 BATF ZNF217 IKZF1 EED ZSCAN29 IKZF2 INTS12 LOC105377352 ARHGEF38 ARHGEF38-IT1 ENSG00000248778
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGEF38 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGEF38 Gene

Chromosome:
4
Start:
105,552,522 bp from pter
End:
105,708,093 bp from pter
Size:
155,572 bases
Orientation:
Plus strand

Genomic View for ARHGEF38 Gene

Genes around ARHGEF38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF38 Gene

Proteins for ARHGEF38 Gene

  • Protein details for ARHGEF38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXL2-ARH38_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 38
    Protein Accession:
    Q9NXL2
    Secondary Accessions:
    • C9JIB4

    Protein attributes for ARHGEF38 Gene

    Size:
    777 amino acids
    Molecular mass:
    89078 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARHGEF38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF38 Gene

Post-translational modifications for ARHGEF38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF38 Gene

No data available for DME Specific Peptides for ARHGEF38 Gene

Domains & Families for ARHGEF38 Gene

Gene Families for ARHGEF38 Gene

Protein Domains for ARHGEF38 Gene

Suggested Antigen Peptide Sequences for ARHGEF38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGEF38: view

No data available for UniProtKB/Swiss-Prot for ARHGEF38 Gene

Function for ARHGEF38 Gene

Molecular function for ARHGEF38 Gene

UniProtKB/Swiss-Prot Function:
May act as a guanine-nucleotide releasing factor.

Phenotypes From GWAS Catalog for ARHGEF38 Gene

Gene Ontology (GO) - Molecular Function for ARHGEF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IBA --
genes like me logo Genes that share ontologies with ARHGEF38: view

Phenotypes for ARHGEF38 Gene

GenomeRNAi human phenotypes for ARHGEF38:
genes like me logo Genes that share phenotypes with ARHGEF38: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARHGEF38
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGEF38 Gene

Localization for ARHGEF38 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF38 gene
Compartment Confidence
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for ARHGEF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARHGEF38: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF38 Gene

Pathways & Interactions for ARHGEF38 Gene

genes like me logo Genes that share pathways with ARHGEF38: view

Interacting Proteins for ARHGEF38 Gene

Gene Ontology (GO) - Biological Process for ARHGEF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction IBA --
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IBA --
genes like me logo Genes that share ontologies with ARHGEF38: view

No data available for SIGNOR curated interactions for ARHGEF38 Gene

Drugs & Compounds for ARHGEF38 Gene

No Compound Related Data Available

Transcripts for ARHGEF38 Gene

mRNA/cDNA for ARHGEF38 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGEF38 Gene

Rho guanine nucleotide exchange factor (GEF) 38:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARHGEF38
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF38 Gene

No ASD Table

Relevant External Links for ARHGEF38 Gene

GeneLoc Exon Structure for
ARHGEF38
ECgene alternative splicing isoforms for
ARHGEF38

Expression for ARHGEF38 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGEF38 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGEF38 Gene

This gene is overexpressed in Pancreas (x9.5), Prostate (x6.2), Breast - Mammary Tissue (x6.1), and Minor Salivary Gland (x5.5).

Protein differential expression in normal tissues from HIPED for ARHGEF38 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGEF38 Gene



Protein tissue co-expression partners for ARHGEF38 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF38 Gene:

ARHGEF38

SOURCE GeneReport for Unigene cluster for ARHGEF38 Gene:

Hs.585224

Evidence on tissue expression from TISSUES for ARHGEF38 Gene

  • Intestine(4.3)
  • Lung(2.8)
genes like me logo Genes that share expression patterns with ARHGEF38: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF38 Gene

Orthologs for ARHGEF38 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF38 33 34
  • 99.61 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 90 (a)
OneToMany
ARHGEF38 33
  • 88.76 (n)
-- 34
  • 69 (a)
OneToMany
dog
(Canis familiaris)
Mammalia ARHGEF38 33 34
  • 87.59 (n)
mouse
(Mus musculus)
Mammalia Arhgef38 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef38 33
  • 81.61 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF38 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 73 (a)
OneToMany
-- 34
  • 72 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARHGEF38 33 34
  • 72.11 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGEF38 34
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef38 33
  • 66.88 (n)
zebrafish
(Danio rerio)
Actinopterygii arhgef38 33
  • 59.36 (n)
ARHGEF38 34
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y37A1B.17 34
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
OneToMany
Species where no ortholog for ARHGEF38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF38 Gene

ENSEMBL:
Gene Tree for ARHGEF38 (if available)
TreeFam:
Gene Tree for ARHGEF38 (if available)

Paralogs for ARHGEF38 Gene

Paralogs for ARHGEF38 Gene

(2) SIMAP similar genes for ARHGEF38 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF38: view

Variants for ARHGEF38 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF38 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_038928 A breast cancer sample
rs1000021911 -- 105,578,198(+) CAGGA(A/G)CAGAT intron-variant
rs1000033053 -- 105,616,636(+) GGGGG(A/G)ACACA intron-variant
rs1000078520 -- 105,658,930(+) TCTGG(A/G)TAGGT intron-variant
rs1000092176 -- 105,657,066(+) ATAGA(G/T)AGATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF38 Gene

Variant ID Type Subtype PubMed ID
dgv5354n100 CNV loss 25217958
esv22942 CNV loss 19812545
esv2662994 CNV deletion 23128226
esv2728101 CNV deletion 23290073
esv2728102 CNV deletion 23290073
esv2728103 CNV deletion 23290073
esv3309216 CNV mobile element insertion 20981092
esv3365323 CNV insertion 20981092
esv3368333 CNV insertion 20981092
esv3392752 CNV insertion 20981092
esv3601664 CNV loss 21293372
esv3601667 CNV loss 21293372
nsv1000196 CNV loss 25217958
nsv1142403 CNV tandem duplication 24896259
nsv290938 CNV deletion 16902084
nsv291273 CNV deletion 16902084
nsv461610 CNV loss 19166990
nsv517837 CNV loss 19592680
nsv518958 CNV gain 19592680
nsv524424 CNV loss 19592680
nsv595008 CNV loss 21841781

Variation tolerance for ARHGEF38 Gene

Gene Damage Index Score: 8.36; 85.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF38 Gene

Disorders for ARHGEF38 Gene

Relevant External Links for ARHGEF38

Genetic Association Database (GAD)
ARHGEF38
Human Genome Epidemiology (HuGE) Navigator
ARHGEF38
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF38

No disorders were found for ARHGEF38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF38 Gene

Publications for ARHGEF38 Gene

  1. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  2. Gene network analysis in a pediatric cohort identifies novel lung function genes. (PMID: 24023788) Ong BA … Hakonarson H (PloS one 2013) 3 60
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 60
  4. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M … Kaibuchi K (Journal of human genetics 2010) 3 60
  5. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G … Riley BP (Human molecular genetics 2010) 3 60

Products for ARHGEF38 Gene

Sources for ARHGEF38 Gene

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