Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARHGEF38 Gene

Aliases for ARHGEF38 Gene

  • Rho Guanine Nucleotide Exchange Factor 38 2 3 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 38 2

External Ids for ARHGEF38 Gene

Previous GeneCards Identifiers for ARHGEF38 Gene

  • GC04P106474
  • GC04P102208

Summaries for ARHGEF38 Gene

GeneCards Summary for ARHGEF38 Gene

ARHGEF38 (Rho Guanine Nucleotide Exchange Factor 38) is a Protein Coding gene. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DNMBP.

UniProtKB/Swiss-Prot for ARHGEF38 Gene

  • May act as a guanine-nucleotide releasing factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF38 Gene

Genomics for ARHGEF38 Gene

Genomic Location for ARHGEF38 Gene

Chromosome:
4
Start:
105,552,522 bp from pter
End:
105,708,093 bp from pter
Size:
155,572 bases
Orientation:
Plus strand

Genomic View for ARHGEF38 Gene

Genes around ARHGEF38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF38 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF38 Gene

No data available for Regulatory Elements for ARHGEF38 Gene

Proteins for ARHGEF38 Gene

  • Protein details for ARHGEF38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NXL2-ARH38_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 38
    Protein Accession:
    Q9NXL2
    Secondary Accessions:
    • C9JIB4

    Protein attributes for ARHGEF38 Gene

    Size:
    777 amino acids
    Molecular mass:
    89078 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for ARHGEF38 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF38 Gene

Proteomics data for ARHGEF38 Gene at MOPED

Post-translational modifications for ARHGEF38 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF38 Gene

Domains & Families for ARHGEF38 Gene

Gene Families for ARHGEF38 Gene

Protein Domains for ARHGEF38 Gene

Suggested Antigen Peptide Sequences for ARHGEF38 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NXL2

UniProtKB/Swiss-Prot:

ARH38_HUMAN :
  • Contains 1 BAR domain.
Domain:
  • Contains 1 BAR domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGEF38: view

Function for ARHGEF38 Gene

Molecular function for ARHGEF38 Gene

UniProtKB/Swiss-Prot Function:
May act as a guanine-nucleotide releasing factor.

Gene Ontology (GO) - Molecular Function for ARHGEF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with ARHGEF38: view

Phenotypes for ARHGEF38 Gene

GenomeRNAi human phenotypes for ARHGEF38:
genes like me logo Genes that share phenotypes with ARHGEF38: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGEF38 Gene

Localization for ARHGEF38 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF38 Gene COMPARTMENTS Subcellular localization image for ARHGEF38 gene
Compartment Confidence
cytosol 1
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGEF38 Gene

Pathways & Interactions for ARHGEF38 Gene

SuperPathways for ARHGEF38 Gene

No Data Available

Interacting Proteins for ARHGEF38 Gene

Gene Ontology (GO) - Biological Process for ARHGEF38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGEF38: view

No data available for Pathways by source and SIGNOR curated interactions for ARHGEF38 Gene

Drugs & Compounds for ARHGEF38 Gene

No Compound Related Data Available

Transcripts for ARHGEF38 Gene

mRNA/cDNA for ARHGEF38 Gene

(5) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGEF38 Gene

Rho guanine nucleotide exchange factor (GEF) 38:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF38 Gene

No ASD Table

Relevant External Links for ARHGEF38 Gene

GeneLoc Exon Structure for
ARHGEF38
ECgene alternative splicing isoforms for
ARHGEF38

Expression for ARHGEF38 Gene

mRNA expression in normal human tissues for ARHGEF38 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGEF38 Gene

This gene is overexpressed in Pancreas (x9.5), Prostate (x6.2), Breast - Mammary Tissue (x6.1), and Minor Salivary Gland (x5.5).

Protein differential expression in normal tissues from HIPED for ARHGEF38 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGEF38 Gene



SOURCE GeneReport for Unigene cluster for ARHGEF38 Gene Hs.585224

genes like me logo Genes that share expression patterns with ARHGEF38: view

Protein tissue co-expression partners for ARHGEF38 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARHGEF38 Gene

Orthologs for ARHGEF38 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF38 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF38 35
  • 99.61 (n)
  • 99.49 (a)
ARHGEF38 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 69 (a)
OneToMany
-- 36
  • 90 (a)
OneToMany
ARHGEF38 35
  • 88.76 (n)
  • 87.9 (a)
dog
(Canis familiaris)
Mammalia ARHGEF38 35
  • 87.59 (n)
  • 87.11 (a)
ARHGEF38 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef38 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF38 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 73 (a)
OneToMany
-- 36
  • 72 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arhgef38 35
  • 81.61 (n)
  • 83.69 (a)
chicken
(Gallus gallus)
Aves ARHGEF38 35
  • 72.11 (n)
  • 71.28 (a)
ARHGEF38 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF38 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef38 35
  • 66.88 (n)
  • 65.07 (a)
zebrafish
(Danio rerio)
Actinopterygii ARHGEF38 36
  • 44 (a)
OneToOne
arhgef38 35
  • 59.36 (n)
  • 55.75 (a)
worm
(Caenorhabditis elegans)
Secernentea Y37A1B.17 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for ARHGEF38:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF38 Gene

ENSEMBL:
Gene Tree for ARHGEF38 (if available)
TreeFam:
Gene Tree for ARHGEF38 (if available)

Paralogs for ARHGEF38 Gene

Paralogs for ARHGEF38 Gene

(2) SIMAP similar genes for ARHGEF38 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF38: view

Variants for ARHGEF38 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF38 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_038928 A breast cancer sample
rs2276970 - 105,589,313(+) ATCAT(A/G)TGAAG intron-variant, nc-transcript-variant, reference, missense
rs199317 -- 105,578,152(+) atact(C/T)aaatt intron-variant
rs199320 -- 105,579,386(+) tctta(C/T)tattt intron-variant
rs199321 -- 105,579,454(+) gaacc(A/G)tatca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF38 Gene

Variant ID Type Subtype PubMed ID
nsv879699 CNV Gain 21882294
nsv461610 CNV Loss 19166990
nsv524424 CNV Loss 19592680
nsv517837 CNV Loss 19592680
esv2728101 CNV Deletion 23290073
esv2728102 CNV Deletion 23290073
nsv291273 CNV Loss 16902084
esv2728103 CNV Deletion 23290073
nsv290938 CNV Loss 16902084
nsv518958 CNV Gain 19592680
esv2662994 CNV Deletion 23128226
esv271243 CNV Insertion 20981092
esv273489 CNV Insertion 20981092
esv267409 CNV Insertion 20981092
esv22942 CNV Loss 19812545

Variation tolerance for ARHGEF38 Gene

Gene Damage Index Score: 8.36; 85.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF38 Gene

HapMap Linkage Disequilibrium report
ARHGEF38

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF38 Gene

Disorders for ARHGEF38 Gene

Relevant External Links for ARHGEF38

Genetic Association Database (GAD)
ARHGEF38
Human Genome Epidemiology (HuGE) Navigator
ARHGEF38
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF38

No disorders were found for ARHGEF38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF38 Gene

Publications for ARHGEF38 Gene

  1. Gene network analysis in a pediatric cohort identifies novel lung function genes. (PMID: 24023788) Ong B.A. … Hakonarson H. (PLoS ONE 2013) 3 67
  2. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  4. A systematic gene-based screen of chr4q22-q32 identifies association of a novel susceptibility gene, DKK2, with the quantitative trait of alcohol dependence symptom counts. (PMID: 20332099) Kalsi G. … Riley B.P. (Hum. Mol. Genet. 2010) 3
  5. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. (PMID: 20010835) Hancock D.B. … London S.J. (Nat. Genet. 2010) 3

Products for ARHGEF38 Gene

Sources for ARHGEF38 Gene

Back to Top

Content