Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARHGEF37 Gene

Aliases for ARHGEF37 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 37 2 3

External Ids for ARHGEF37 Gene

Previous GeneCards Identifiers for ARHGEF37 Gene

  • GC05P148961
  • GC05P144107

Summaries for ARHGEF37 Gene

GeneCards Summary for ARHGEF37 Gene

ARHGEF37 (Rho Guanine Nucleotide Exchange Factor (GEF) 37) is a Protein Coding gene. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is DNMBP.

UniProtKB/Swiss-Prot for ARHGEF37 Gene

  • May act as a guanine nucleotide exchange factor (GEF).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF37 Gene

Genomics for ARHGEF37 Gene

Genomic Location for ARHGEF37 Gene

149,551,947 bp from pter
149,634,968 bp from pter
83,022 bases
Plus strand

Genomic View for ARHGEF37 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF37 Gene

No data available for Regulatory Elements for ARHGEF37 Gene

Proteins for ARHGEF37 Gene

  • Protein details for ARHGEF37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 37
    Protein Accession:
    Secondary Accessions:
    • Q6ZW51

    Protein attributes for ARHGEF37 Gene

    675 amino acids
    Molecular mass:
    76278 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC85655.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for ARHGEF37 Gene

Proteomics data for ARHGEF37 Gene at MOPED

Post-translational modifications for ARHGEF37 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF37 Gene

Domains for ARHGEF37 Gene

Gene Families for ARHGEF37 Gene

  • ARHGEF :Rho guanine nucleotide exchange factors

Protein Domains for ARHGEF37 Gene

Suggested Antigen Peptide Sequences for ARHGEF37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A1IGU5
  • Contains 1 BAR domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 2 SH3 domains.
genes like me logo Genes that share domains with ARHGEF37: view

Function for ARHGEF37 Gene

Molecular function for ARHGEF37 Gene

UniProtKB/Swiss-Prot Function: May act as a guanine nucleotide exchange factor (GEF).

Gene Ontology (GO) - Molecular Function for ARHGEF37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ARHGEF37: view

miRNA for ARHGEF37 Gene

miRTarBase miRNAs that target ARHGEF37

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGEF37 Gene

Localization for ARHGEF37 Gene

Subcellular locations from

Jensen Localization Image for ARHGEF37 Gene COMPARTMENTS Subcellular localization image for ARHGEF37 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ARHGEF37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARHGEF37: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF37 Gene

Pathways for ARHGEF37 Gene

SuperPathways for ARHGEF37 Gene

No Data Available

Interacting Proteins for ARHGEF37 Gene

Gene Ontology (GO) - Biological Process for ARHGEF37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGEF37: view

No data available for Pathways by source for ARHGEF37 Gene

Compounds for ARHGEF37 Gene

(3) HMDB Compounds for ARHGEF37 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with ARHGEF37: view

Transcripts for ARHGEF37 Gene

Unigene Clusters for ARHGEF37 Gene

Rho guanine nucleotide exchange factor (GEF) 37:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF37 Gene

No ASD Table

Relevant External Links for ARHGEF37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGEF37 Gene

mRNA expression in normal human tissues for ARHGEF37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF37 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARHGEF37 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF37 Gene Hs.256206

genes like me logo Genes that share expressions with ARHGEF37: view

No data available for mRNA Expression by UniProt/SwissProt for ARHGEF37 Gene

Orthologs for ARHGEF37 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGEF37 35
  • 98.91 (n)
  • 98.67 (a)
  • 99 (a)
(Bos Taurus)
Mammalia ARHGEF37 35
  • 87.43 (n)
  • 86.14 (a)
  • 86 (a)
(Canis familiaris)
Mammalia ARHGEF37 35
  • 86.72 (n)
  • 84.59 (a)
  • 85 (a)
(Mus musculus)
Mammalia Arhgef37 35
  • 81.19 (n)
  • 79.56 (a)
Arhgef37 16
Arhgef37 36
  • 79 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
-- 36
  • 53 (a)
-- 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGEF37 36
  • 57 (a)
(Rattus norvegicus)
Mammalia Arhgef37 35
  • 82.57 (n)
  • 80.89 (a)
(Gallus gallus)
Aves ARHGEF37 35
  • 64.08 (n)
  • 56.72 (a)
  • 56 (a)
(Anolis carolinensis)
Reptilia ARHGEF37 36
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef37 35
  • 53.59 (n)
  • 43.04 (a)
(Danio rerio)
Actinopterygii CU074314.1 36
  • 36 (a)
LOC101883655 35
  • 51.61 (n)
  • 40.73 (a)
(Caenorhabditis elegans)
Secernentea Y37A1B.17 36
  • 9 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 30 (a)
Species with no ortholog for ARHGEF37:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF37 Gene

Gene Tree for ARHGEF37 (if available)
Gene Tree for ARHGEF37 (if available)

Paralogs for ARHGEF37 Gene

Paralogs for ARHGEF37 Gene

Selected SIMAP similar genes for ARHGEF37 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARHGEF37: view

Variants for ARHGEF37 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF37 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs717954 -- 149,601,466(+) CTTAC(A/G)GTCAC intron-variant
rs965876 -- 149,614,039(-) tgctt(A/G)taatc intron-variant
rs1056189 -- 149,634,855(+) TGAGG(A/G)CAAGA utr-variant-3-prime
rs1056993 -- 149,628,840(-) AGCTG(C/T)AGTTT reference, synonymous-codon
rs1135093 - 149,628,958(-) GTTCA(C/T)GGTGG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF37 Gene

Variant ID Type Subtype PubMed ID
esv24490 CNV Gain 19812545
nsv516760 CNV Loss 19592680
esv2671746 CNV Deletion 23128226
esv28001 CNV Loss 19812545

Relevant External Links for ARHGEF37 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF37 Gene

Disorders for ARHGEF37 Gene

No disorders were found for ARHGEF37 Gene.

No data available for UniProtKB/Swiss-Prot for ARHGEF37 Gene

Publications for ARHGEF37 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies. (PMID: 23377640) (Am J Psychiatry 2013) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ARHGEF37 Gene

Sources for ARHGEF37 Gene

Back to Top