ARHGEF37 Gene
protein-coding GIFtS: 37
GCID: GC05P148961
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Rho guanine nucleotide exchange factor (GEF) 37
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Aliases
for ARHGEF37 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho Guanine Nucleotide Exchange Factor (GEF) 371 2 | | FLJ416031 | | Rho Guanine Nucleotide Exchange Factor 372 |
Export aliases for ARHGEF37 gene to outside databasesPrevious GC identifer: GC05P144107 |
Summaries
for ARHGEF37 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ARH37_HUMAN, A1IGU5Function: May act as a guanine nucleotide exchange factor (GEF) (By similarity)
|
Genomic Views
for ARHGEF37 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ARHGEF37
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGEF37
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF37 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q32 Ensembl cytogenetic band: 5q32 HGNC cytogenetic band: 5q33.1ARHGEF37 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P148961: view genomic region
(about GC identifiers)
Start:
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148,931,510 bp from pter |
End:
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149,014,531 bp from pter |
Size:
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83,022 bases |
Orientation:
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plus strand |
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Proteins
for ARHGEF37 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARH37_HUMAN, A1IGU5 (See
protein sequence)Recommended Name: Rho guanine nucleotide exchange factor 37 Size: 675 amino acids; 76278 Da
Sequence caution: Sequence=BAC85655.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6ZW51Explore the universe of human proteins at neXtProt for ARHGEF37: NX_A1IGU5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A1IGU5
ARHGEF37 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001001669.2
ENSEMBL proteins: ENSP00000425621 ENSP00000328083
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
ARHGEF37 for ontologies About GeneDecksing
ARHGEF37 Antibody Products:
Assay Products for ARHGEF37: |
Protein
Domains /
Families
for ARHGEF37 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGEF37 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry A1IGU5ProtoNet protein and cluster: A1IGU5 UniProtKB/Swiss-Prot: ARH37_HUMAN, A1IGU5Similarity: Contains 1 BAR domainSimilarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 2 SH3 domains |
Function
for ARHGEF37 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARH37_HUMAN, A1IGU5Function: May act as a guanine nucleotide exchange factor (GEF) (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF37 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF37
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARHGEF37 (NM_001001669) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF37 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF37 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF37 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
IEA | -- | | GO:0019904 | protein domain specific binding |
IEA | -- |
ARHGEF37 for ontologies About GeneDecksing
|
Pathways & Interactions
for ARHGEF37 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGEF37
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0035023 | regulation of Rho protein signal transduction |
IEA | -- |
ARHGEF37 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGEF37 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARHGEF37
3 HMDB Compounds for ARHGEF37 About this table
Search CenterWatch for drugs/clinical trials and news about ARHGEF37 / ARH37
|
Transcripts
for ARHGEF37 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGEF37 gene: NM_001001669.2 Unigene Cluster for ARHGEF37: Rho guanine nucleotide exchange factor (GEF) 37 Hs.256206 [show with all ESTs]Unigene Representative Sequence: NM_0010016693 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000505810 ENST00000333677(uc003lra.1) ENST00000509831
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF37 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF37
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARHGEF37 (NM_001001669) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF37 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF37 |
Additional cDNA sequence: AB199796.1 AK023814.1 AK123597.1 AK300355.1 AK300559.1 AK316002.1 BC041325.1 6 DOTS entries: DT.97787807 DT.70104998 DT.75101969 DT.120883257 DT.75143607 DT.95235770 24/87 AceView cDNA sequences (see all 87): AI678940 BG681939 AI674408 BU734809 BU732976 AA612626 BE326883 AI583172 BC041325 AI202380 BQ189207 BE646223 AK023814 AW151821 CD722857 CB850773 AI568798 BF939317 CD517154 BM696804 CD107471 CD109730 AI949058 BG057229
GeneLoc Exon Structure
|
Expression
for ARHGEF37 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGEF37 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCACTGTGTC
About this image
See ARHGEF37 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGEF37
SOURCE GeneReport for Unigene cluster: Hs.256206
SABiosciences Custom PCR Arrays for ARHGEF37
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF37
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF37 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF37 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF37 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF37 |
Orthologs
for ARHGEF37 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGEF37 gene from 6/18 species (see all 18) About this table
ENSEMBL Gene Tree for ARHGEF37 (if available)
TreeFam Gene Tree for ARHGEF37 (if available) |
Paralogs
for ARHGEF37 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGEF37 gene
- ARHGEF382 DNMBP2
2 SIMAP similar genes for ARHGEF37 using alignment to 2 protein entries: ARH37_HUMAN (see all proteins):ARHGEF38 ARHGEF16
ARHGEF37 for paralogs About GeneDecksing
|
Genomic Variants
for ARHGEF37 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGEF37 (148931510 - 149014531 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARHGEF37: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF37 |
|
Disorders
/ Diseases
for ARHGEF37 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ARHGEF37 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGEF37 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARHGEF37) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for ARHGEF37 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ARHGEF37 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGEF37 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARHGEF37 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARHGEF37 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for ARHGEF37 gene:
Search GeneIP for patents involving ARHGEF37
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARHGEF37 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF37 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF37 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for ARHGEF37 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF37 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF37 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ARHGEF37 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARHGEF37 | | OriGene Custom Protein Services for ARHGEF37 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGEF37 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF37 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF37 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF37 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF37 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF37 |
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 | | | ARHGEF37 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF37 |
|  |  |  | | | | Search ThermoFisher Antibodies for ARHGEF37 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF37 |
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