ARHGEF35 Gene
protein-coding GIFtS: 30
GCID: GC07M143883
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Rho guanine nucleotide exchange factor (GEF) 35(Previous name: Rho guanine nucleotide exchange factor (GEF) 5-like )
(Previous symbol: ARHGEF5L)
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Aliases
for ARHGEF35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho Guanine Nucleotide Exchange Factor (GEF) 351 2 | | FLJ436921 | | ARHGEF5L1 2 3 | | Rho Guanine Nucleotide Exchange Factor (GEF) 5-Like1 | | Rho Guanine Nucleotide Exchange Factor 5-Like Protein2 3 | | Rho Guanine Nucleotide Exchange Factor 352 | | CTAGE41 | | |
Export aliases for ARHGEF35 gene to outside databasesPrevious GC identifer: GC07M138082 |
Summaries
for ARHGEF35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for ARHGEF35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for ARHGEF35
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGEF35
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF35 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q35 Ensembl cytogenetic band: 7q35 HGNC cytogenetic band: 7q35ARHGEF35 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M143883: view genomic region
(about GC identifiers)
Start:
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143,883,176 bp from pter |
End:
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143,991,230 bp from pter |
Size:
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108,055 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 143,221,434-143,231,049 |
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Proteins
for ARHGEF35 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARG35_HUMAN, A5YM69 (See
protein sequence)Recommended Name: Rho guanine nucleotide exchange factor 35 Size: 484 amino acids; 53287 Da
Secondary accessions: Q6ZUI2Explore the universe of human proteins at neXtProt for ARHGEF35: NX_A5YM69
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A5YM69
ARHGEF35 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001003702.2
ENSEMBL proteins: ENSP00000367355 ENSP00000438502
Human Recombinant Protein Products:
ARHGEF35 Antibody Products:
Assay Products for ARHGEF35: |
Protein
Domains /
Families
for ARHGEF35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: A5YM69 |
Function
for ARHGEF35 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF35
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF35
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARHGEF35 (NM_001003702) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF35 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF35 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF35 |
|
Pathways & Interactions
for ARHGEF35 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGEF35
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for ARHGEF35 (ENSP000003673554) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for ARHGEF35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARHGEF35
Search CenterWatch for drugs/clinical trials and news about ARHGEF35 / ARG35
|
Transcripts
for ARHGEF35 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGEF35 gene: NM_001003702.2 Unigene Cluster for ARHGEF35: Rho guanine nucleotide exchange factor (GEF) 35 Hs.534621 [show with all ESTs]Unigene Representative Sequence: NM_0010037022 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378115(uc003wdz.2) ENST00000543357
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF35
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF35
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARHGEF35 (NM_001003702) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF35 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF35 |
Additional cDNA sequence: AK125680.1 BC136868.1 BC136878.1 DQ786206.1 EF560743.1 5 DOTS entries: DT.91743124 DT.97806985 DT.95088786 DT.121037396 DT.100649037
GeneLoc Exon Structure
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Expression
for ARHGEF35 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGEF35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ARHGEF35 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.534621
SABiosciences Custom PCR Arrays for ARHGEF35
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF35
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat ARHGEF35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF35 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF35 |
Orthologs
for ARHGEF35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for ARHGEF35 (if available)
TreeFam Gene Tree for ARHGEF35 (if available) |
Paralogs
for ARHGEF35 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for ARHGEF35 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGEF35 (143883176 - 143991230 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARHGEF35: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF35 |
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Disorders
/ Diseases
for ARHGEF35 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for ARHGEF35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGEF35 gene integrated from 9 sources:
(articles sorted by number of sources associating them with ARHGEF35) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for ARHGEF35 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing ARHGEF35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGEF35 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing ARHGEF35 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARHGEF35 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARHGEF35 gene:
Search GeneIP for patents involving ARHGEF35
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARHGEF35 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARHGEF35 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF35 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF35 | | | OriGene Protein Over-expression Lysate for ARHGEF35 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARHGEF35 | | OriGene 3'-UTR Clone for ARHGEF35 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF35 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF35 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ARHGEF35 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARHGEF35 | | OriGene Custom Protein Services for ARHGEF35 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGEF35 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF35 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF35 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF35 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF35 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF35 |
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 | | | ARHGEF35 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF35 |
|  |  |  | | | | Search ThermoFisher Antibodies for ARHGEF35 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF35 |
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