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Aliases for ARHGEF35 Gene

Aliases for ARHGEF35 Gene

  • Rho Guanine Nucleotide Exchange Factor 35 2 3 5
  • Rho Guanine Nucleotide Exchange Factor 5-Like Protein 3 4
  • Rho Guanine Nucleotide Exchange Factor (GEF) 35 2 3
  • ARHGEF5L 3 4
  • Rho Guanine Nucleotide Exchange Factor (GEF) 5-Like 2

External Ids for ARHGEF35 Gene

Previous HGNC Symbols for ARHGEF35 Gene

  • ARHGEF5L

Previous GeneCards Identifiers for ARHGEF35 Gene

  • GC07M143883
  • GC07M138082

Summaries for ARHGEF35 Gene

GeneCards Summary for ARHGEF35 Gene

ARHGEF35 (Rho Guanine Nucleotide Exchange Factor 35) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. An important paralog of this gene is ARHGEF5.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF35 Gene

Genomics for ARHGEF35 Gene

Regulatory Elements for ARHGEF35 Gene

Enhancers for ARHGEF35 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F143898 1.7 FANTOM5 Ensembl ENCODE 15.2 +292.5 292542 9.0 HDGF CREB3L1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ARHGEF35 OR2A13P TCAF1 OR2A25 OR2A12 ARHGEF34P OR2A2 OR2F1
GH07F144018 1 Ensembl ENCODE 25.5 +175.6 175589 3.4 SOX13 JUN CEBPG RAD21 GATA3 CTBP1 FOS FOSL2 MAFK TCF7L2 ARHGEF35 OR2A5 ENSG00000243583 OR2F1 LOC154761 OR6B1
GH07F143933 0.7 ENCODE 23.7 +260.3 260294 2.9 RFX1 HLF MAFG JUND MAFF ZNF316 ZFHX2 ATF3 MAFK EMSY ARHGEF35 OR2F1 TCAF1 OR2A7 OR2F2 ENSG00000243583
GH07F144031 0.4 ENCODE 24.5 +164.0 163956 1.3 HNF4G NR2F2 ARHGEF35 OR2A25 OR2A41P OR2A5 OR6B1
GH07F143884 0.7 ENCODE 11.8 +310.3 310288 1.1 PKNOX1 NFYA REST ZBTB7A RAD21 ZFHX2 CBX1 POLR2A EGR1 PBX2 ARHGEF35 TCAF1 LOC105375549 GC07M143854
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGEF35 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGEF35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001718789 -2 2201 HDAC1 ATF1 CBX3 TBL1XR1 RAD21 CHAMP1 CREM MIXL1 ZNF362 ZNF654

Genomic Location for ARHGEF35 Gene

Chromosome:
7
Start:
144,186,083 bp from pter
End:
144,195,698 bp from pter
Size:
9,616 bases
Orientation:
Minus strand

Genomic View for ARHGEF35 Gene

Genes around ARHGEF35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF35 Gene

Proteins for ARHGEF35 Gene

  • Protein details for ARHGEF35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5YM69-ARG35_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 35
    Protein Accession:
    A5YM69
    Secondary Accessions:
    • Q6ZUI2

    Protein attributes for ARHGEF35 Gene

    Size:
    484 amino acids
    Molecular mass:
    53287 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARHGEF35 Gene

Post-translational modifications for ARHGEF35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF35 Gene

Domains & Families for ARHGEF35 Gene

Gene Families for ARHGEF35 Gene

Protein Domains for ARHGEF35 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for ARHGEF35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGEF35: view

No data available for UniProtKB/Swiss-Prot for ARHGEF35 Gene

Function for ARHGEF35 Gene

genes like me logo Genes that share phenotypes with ARHGEF35: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGEF35 Gene

Localization for ARHGEF35 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF35 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGEF35 Gene

Pathways & Interactions for ARHGEF35 Gene

genes like me logo Genes that share pathways with ARHGEF35: view

Interacting Proteins for ARHGEF35 Gene

Gene Ontology (GO) - Biological Process for ARHGEF35 Gene

None

No data available for SIGNOR curated interactions for ARHGEF35 Gene

Transcripts for ARHGEF35 Gene

mRNA/cDNA for ARHGEF35 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGEF35 Gene

Rho guanine nucleotide exchange factor (GEF) 35:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF35 Gene

No ASD Table

Relevant External Links for ARHGEF35 Gene

GeneLoc Exon Structure for
ARHGEF35
ECgene alternative splicing isoforms for
ARHGEF35

Expression for ARHGEF35 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF35 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGEF35 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.4), Esophagus - Mucosa (x4.9), and Skin - Not Sun Exposed (Suprapubic) (x4.3).

Protein differential expression in normal tissues from HIPED for ARHGEF35 Gene

This gene is overexpressed in Islet of Langerhans (51.6) and Placenta (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGEF35 Gene



Protein tissue co-expression partners for ARHGEF35 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF35 Gene:

ARHGEF35

SOURCE GeneReport for Unigene cluster for ARHGEF35 Gene:

Hs.534621
genes like me logo Genes that share expression patterns with ARHGEF35: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARHGEF35 Gene

Orthologs for ARHGEF35 Gene

Evolution for ARHGEF35 Gene

ENSEMBL:
Gene Tree for ARHGEF35 (if available)
TreeFam:
Gene Tree for ARHGEF35 (if available)

No data available for Orthologs for ARHGEF35 Gene

Paralogs for ARHGEF35 Gene

Paralogs for ARHGEF35 Gene

(2) SIMAP similar genes for ARHGEF35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF35: view

Variants for ARHGEF35 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF35 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1048321 -- 144,185,604(+) CTCCA(A/G)TCAGC downstream-variant-500B, reference, missense
rs111358397 -- 144,191,049(+) TGTCC(A/G)CTTCT intron-variant
rs111575590 -- 144,189,930(+) CCTCC(C/T)GAGTA intron-variant
rs112484381 -- 144,186,669(+) GCTGA(C/T)GAAAC utr-variant-3-prime
rs113654434 -- 144,186,935(+) CAAAG(A/T)ACTGA reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF35 Gene

Variant ID Type Subtype PubMed ID
nsv970956 CNV duplication 23825009
nsv831176 CNV loss 17160897
nsv831175 CNV loss 17160897
nsv831174 CNV loss 17160897
nsv824360 CNV gain 20364138
nsv8227 CNV gain+loss 18304495
nsv821609 CNV duplication 20802225
nsv819701 CNV insertion 19587683
nsv7411 OTHER inversion 18451855
nsv608721 CNV gain 21841781
nsv608699 CNV gain 21841781
nsv515040 CNV gain 21397061
nsv482116 CNV gain 20164927
nsv471454 CNV gain 19718026
nsv433394 CNV gain 18776910
nsv428188 CNV gain+loss 18775914
nsv1148453 CNV duplication 26484159
nsv1141557 CNV duplication 24896259
nsv1119234 CNV duplication 24896259
nsv1032320 CNV gain 25217958
nsv1016831 CNV gain 25217958
esv3891225 CNV gain 25118596
esv3432947 CNV duplication 20981092
esv3411711 CNV duplication 20981092
esv3379639 CNV duplication 20981092
esv3369041 CNV duplication 20981092
esv33253 CNV gain 17666407
esv2759570 CNV gain+loss 17122850
esv24292 CNV gain+loss 19812545
esv1682998 OTHER inversion 17803354
esv1003295 OTHER inversion 20482838
dgv6730n100 CNV loss 25217958
dgv6729n100 CNV gain 25217958
dgv6728n100 CNV gain+loss 25217958
dgv6727n100 CNV loss 25217958
dgv6726n100 CNV gain 25217958
dgv6725n100 CNV gain 25217958
dgv3968e59 CNV duplication 20981092
dgv3967e59 CNV duplication 20981092
dgv3966e59 CNV duplication 20981092
dgv3965e59 CNV duplication 20981092
dgv253n111 CNV duplication 26073780
dgv24n31 CNV gain 19718026
dgv152e203 CNV gain+loss 21179565
dgv11669n54 CNV loss 21841781
dgv11668n54 CNV gain 21841781

Variation tolerance for ARHGEF35 Gene

Gene Damage Index Score: 1.25; 24.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF35 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF35

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF35 Gene

Disorders for ARHGEF35 Gene

Relevant External Links for ARHGEF35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF35

No disorders were found for ARHGEF35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF35 Gene

Publications for ARHGEF35 Gene

  1. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 64
  2. A quantitative atlas of mitotic phosphorylation. (PMID: 18669648) Dephoure N. … Gygi S.P. (Proc. Natl. Acad. Sci. U.S.A. 2008) 4 64
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  4. Lineage-specific gene duplication and loss in human and great ape evolution. (PMID: 15252450) Fortna A. … Sikela J.M. (PLoS Biol. 2004) 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64

Products for ARHGEF35 Gene

Sources for ARHGEF35 Gene

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