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Aliases for ARHGEF35 Gene

Aliases for ARHGEF35 Gene

  • Rho Guanine Nucleotide Exchange Factor 35 2 3 5
  • Rho Guanine Nucleotide Exchange Factor 5-Like Protein 3 4
  • Rho Guanine Nucleotide Exchange Factor (GEF) 35 2 3
  • ARHGEF5L 3 4
  • Rho Guanine Nucleotide Exchange Factor (GEF) 5-Like 2

External Ids for ARHGEF35 Gene

Previous HGNC Symbols for ARHGEF35 Gene


Previous GeneCards Identifiers for ARHGEF35 Gene

  • GC07M143883
  • GC07M138082

Summaries for ARHGEF35 Gene

GeneCards Summary for ARHGEF35 Gene

ARHGEF35 (Rho Guanine Nucleotide Exchange Factor 35) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF35 Gene

Genomics for ARHGEF35 Gene

Regulatory Elements for ARHGEF35 Gene

Enhancers for ARHGEF35 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGEF35 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGEF35 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGEF35 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGEF35 Gene

144,186,083 bp from pter
144,195,698 bp from pter
9,616 bases
Minus strand

Genomic View for ARHGEF35 Gene

Genes around ARHGEF35 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF35 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF35 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF35 Gene

Proteins for ARHGEF35 Gene

  • Protein details for ARHGEF35 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 35
    Protein Accession:
    Secondary Accessions:
    • Q6ZUI2

    Protein attributes for ARHGEF35 Gene

    484 amino acids
    Molecular mass:
    53287 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARHGEF35 Gene

Proteomics data for ARHGEF35 Gene at MOPED

Post-translational modifications for ARHGEF35 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF35 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF35 Gene

Domains & Families for ARHGEF35 Gene

Gene Families for ARHGEF35 Gene

Protein Domains for ARHGEF35 Gene


Suggested Antigen Peptide Sequences for ARHGEF35 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with ARHGEF35: view

No data available for UniProtKB/Swiss-Prot for ARHGEF35 Gene

Function for ARHGEF35 Gene

Phenotypes for ARHGEF35 Gene

genes like me logo Genes that share phenotypes with ARHGEF35: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGEF35 Gene

Localization for ARHGEF35 Gene

Subcellular locations from

Jensen Localization Image for ARHGEF35 Gene COMPARTMENTS Subcellular localization image for ARHGEF35 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGEF35 Gene

Pathways & Interactions for ARHGEF35 Gene

SuperPathways for ARHGEF35 Gene

No Data Available

Interacting Proteins for ARHGEF35 Gene

Gene Ontology (GO) - Biological Process for ARHGEF35 Gene


No data available for Pathways by source and SIGNOR curated interactions for ARHGEF35 Gene

Drugs & Compounds for ARHGEF35 Gene

No Compound Related Data Available

Transcripts for ARHGEF35 Gene

mRNA/cDNA for ARHGEF35 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGEF35 Gene

Rho guanine nucleotide exchange factor (GEF) 35:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF35 Gene

No ASD Table

Relevant External Links for ARHGEF35 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGEF35 Gene

mRNA expression in normal human tissues for ARHGEF35 Gene

mRNA differential expression in normal tissues according to GTEx for ARHGEF35 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x5.4), Esophagus - Mucosa (x4.9), and Skin - Not Sun Exposed (Suprapubic) (x4.3).

Protein differential expression in normal tissues from HIPED for ARHGEF35 Gene

This gene is overexpressed in Islet of Langerhans (51.6) and Placenta (17.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGEF35 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF35 Gene Hs.534621

genes like me logo Genes that share expression patterns with ARHGEF35: view

Protein tissue co-expression partners for ARHGEF35 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for ARHGEF35 Gene

Orthologs for ARHGEF35 Gene

Evolution for ARHGEF35 Gene

Gene Tree for ARHGEF35 (if available)
Gene Tree for ARHGEF35 (if available)

No data available for Orthologs for ARHGEF35 Gene

Paralogs for ARHGEF35 Gene

(2) SIMAP similar genes for ARHGEF35 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF35: view

No data available for Paralogs for ARHGEF35 Gene

Variants for ARHGEF35 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF35 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1208364 -- 144,193,202(-) ATGCA(A/G)AATGT intron-variant
rs1610542 -- 144,191,352(+) CCCCC(C/T)CCCCC intron-variant
rs1610543 -- 144,191,354(+) CCCCC(C/T)CCCAC intron-variant
rs1635897 -- 144,187,277(+) ACTGG(C/G)ACCCC reference, synonymous-codon
rs1731218 -- 144,189,646(+) CAATC(A/G)ACATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF35 Gene

Variant ID Type Subtype PubMed ID
nsv428188 CNV Gain+Loss 18775914
dgv2148e1 CNV Complex 17122850
nsv8227 CNV Gain+Loss 18304495
esv1682998 OTHER Inversion 17803354
dgv7520n71 CNV Gain 21882294
dgv2149e1 CNV Complex 17122850
dgv2150e1 CNV Complex 17122850
nsv831174 CNV Loss 17160897
dgv7521n71 CNV Gain 21882294
essv3984 CNV CNV 17122850
nsv7411 OTHER Inversion 18451855
dgv7522n71 CNV Gain 21882294
dgv7523n71 CNV Gain 21882294
dgv7524n71 CNV Gain+Loss 21882294
esv1003295 OTHER Inversion 20482838
dgv7525n71 CNV Loss 21882294
nsv821609 CNV Duplication 20802225
nsv824360 CNV Gain 20364138
dgv24n31 CNV Duplication 19718026
nsv819701 CNV Insertion 19587683
esv24292 CNV Gain+Loss 19812545
nsv831175 CNV Loss 17160897
nsv831176 CNV Loss 17160897
nsv471454 CNV Duplication 19718026
nsv482116 CNV Gain 20164927
esv33253 CNV Gain 17666407
nsv515040 CNV Complex 21397061
nsv433394 CNV Gain 18776910

Variation tolerance for ARHGEF35 Gene

Gene Damage Index Score: 1.25; 24.92% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for ARHGEF35 Gene

Disorders for ARHGEF35 Gene

Relevant External Links for ARHGEF35

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARHGEF35 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF35 Gene

Publications for ARHGEF35 Gene

  1. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3 67
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  3. Lineage-specific gene duplication and loss in human and great ape evolution. (PMID: 15252450) Fortna A. … Sikela J.M. (PLoS Biol. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for ARHGEF35 Gene

Sources for ARHGEF35 Gene