Free for academic non-profit institutions. Other users need a Commercial license

Aliases for ARHGEF33 Gene

Aliases for ARHGEF33 Gene

  • Rho Guanine Nucleotide Exchange Factor 33 2 3 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 33 2

External Ids for ARHGEF33 Gene

Previous GeneCards Identifiers for ARHGEF33 Gene

  • GC02P039118

Summaries for ARHGEF33 Gene

GeneCards Summary for ARHGEF33 Gene

ARHGEF33 (Rho Guanine Nucleotide Exchange Factor 33) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for ARHGEF33 Gene

  • May act as a guanine-nucleotide releasing factor.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF33 Gene

Genomics for ARHGEF33 Gene

Regulatory Elements for ARHGEF33 Gene

Enhancers for ARHGEF33 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F039215 1.5 FANTOM5 Ensembl ENCODE 13.7 +327.4 327390 2.8 HDAC1 RARA GATA4 GATA2 SIRT6 CREM CEBPB ZNF518A ZNF781 CEBPA SOS1 ARHGEF33 ENSG00000202309 ENSG00000252473 DHX57 MORN2 CDKL4 GC02M039185
GH02F038095 1.3 FANTOM5 ENCODE 13.6 -792.6 -792613 4.5 PKNOX1 FEZF1 GLIS2 KLF7 FOS SP3 TSHZ1 PPARG ZNF518A ZNF623 CYP1B1 CYP1B1-AS1 LINC01883 TTC39DP ENSG00000225284 RPL31P16 SULT6B1 ARHGEF33 RMDN2-AS1 CDC42EP3
GH02F038907 1 ENCODE 14 +18.3 18296 2.1 ZFP64 ARID4B ZNF48 CBX5 ZNF202 SP5 JUNB REST ZNF623 PPARG SOS1 ASS1P2 DHX57 ARHGEF33 RNU6-851P MORN2 ENSG00000225284 GC02M038898 GC02P038937
GH02F038749 1.2 ENCODE 10.9 -138.9 -138921 3.5 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 TTC39DP ENSG00000225284 LINC01883 SOS1 ARHGEF33 ATL2 GALM ASS1P2 DHX57 LOC728730
GH02F038238 0.9 ENCODE 13.6 -650.3 -650341 1.2 ZFP64 ARID4B FEZF1 RAD21 ZNF335 MIXL1 ZNF202 ZNF680 REST MIER2 SOS1 ASS1P2 ARHGEF33 PRKD3 RPLP0P6 ENSG00000229160 ATL2 LOC102723739 GC02P038231
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGEF33 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGEF33 Gene

38,889,880 bp from pter
38,975,449 bp from pter
85,570 bases
Plus strand

Genomic View for ARHGEF33 Gene

Genes around ARHGEF33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF33 Gene

Proteins for ARHGEF33 Gene

  • Protein details for ARHGEF33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 33
    Protein Accession:
    Secondary Accessions:
    • J3KPX2

    Protein attributes for ARHGEF33 Gene

    844 amino acids
    Molecular mass:
    94633 Da
    Quaternary structure:
    No Data Available
    • Sequence=DV080278; Type=Frameshift; Positions=79; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF33 Gene


neXtProt entry for ARHGEF33 Gene

Post-translational modifications for ARHGEF33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF33 Gene

No data available for DME Specific Peptides for ARHGEF33 Gene

Domains & Families for ARHGEF33 Gene

Gene Families for ARHGEF33 Gene

Protein Domains for ARHGEF33 Gene


Suggested Antigen Peptide Sequences for ARHGEF33 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
genes like me logo Genes that share domains with ARHGEF33: view

Function for ARHGEF33 Gene

Molecular function for ARHGEF33 Gene

UniProtKB/Swiss-Prot Function:
May act as a guanine-nucleotide releasing factor.

Gene Ontology (GO) - Molecular Function for ARHGEF33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with ARHGEF33: view

Phenotypes for ARHGEF33 Gene

GenomeRNAi human phenotypes for ARHGEF33:
genes like me logo Genes that share phenotypes with ARHGEF33: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF33 Gene

Localization for ARHGEF33 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF33 gene
Compartment Confidence
nucleus 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGEF33 Gene

Pathways & Interactions for ARHGEF33 Gene

genes like me logo Genes that share pathways with ARHGEF33: view

Interacting Proteins for ARHGEF33 Gene

Selected Interacting proteins: A8MVX0-ARG33_HUMAN for ARHGEF33 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for ARHGEF33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGEF33: view

No data available for SIGNOR curated interactions for ARHGEF33 Gene

Transcripts for ARHGEF33 Gene

mRNA/cDNA for ARHGEF33 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for ARHGEF33 Gene

Rho guanine nucleotide exchange factor (GEF) 33:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF33 Gene

No ASD Table

Relevant External Links for ARHGEF33 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGEF33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF33 Gene

This gene is overexpressed in Brain - Cerebellum (x12.1) and Brain - Cerebellar Hemisphere (x5.9).

Protein differential expression in normal tissues from HIPED for ARHGEF33 Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for ARHGEF33 Gene

Protein tissue co-expression partners for ARHGEF33 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF33 Gene:


SOURCE GeneReport for Unigene cluster for ARHGEF33 Gene:

genes like me logo Genes that share expression patterns with ARHGEF33: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGEF33 Gene

Orthologs for ARHGEF33 Gene

This gene was present in the common ancestor of chordates.

Orthologs for ARHGEF33 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGEF33 34 35
  • 99.73 (n)
(Canis familiaris)
Mammalia ARHGEF33 34 35
  • 93.49 (n)
(Monodelphis domestica)
Mammalia ARHGEF33 35
  • 89 (a)
(Mus musculus)
Mammalia Arhgef33 34 16 35
  • 88.34 (n)
(Rattus norvegicus)
Mammalia Arhgef33 34
  • 86.81 (n)
(Bos Taurus)
Mammalia ARHGEF33 35
  • 86 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 82 (a)
-- 35
  • 56 (a)
(Gallus gallus)
Aves ARHGEF33 34 35
  • 70.31 (n)
(Anolis carolinensis)
Reptilia ARHGEF33 35
  • 65 (a)
(Danio rerio)
Actinopterygii ARHGEF33 35
  • 30 (a)
Species where no ortholog for ARHGEF33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF33 Gene

Gene Tree for ARHGEF33 (if available)
Gene Tree for ARHGEF33 (if available)

Paralogs for ARHGEF33 Gene

No data available for Paralogs for ARHGEF33 Gene

Variants for ARHGEF33 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF33 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10166557 -- 38,940,687(+) cttgc(C/T)ggctt intron-variant
rs10172714 -- 38,970,402(+) GATAA(C/G)TTTAT intron-variant
rs10173312 -- 38,942,488(+) tttaa(A/G)aaagg intron-variant
rs10173563 -- 38,958,248(+) GACCC(A/G)GCCAG intron-variant
rs10181808 -- 38,920,109(+) TTTAT(C/G)GACTT intron-variant

Variation tolerance for ARHGEF33 Gene

Gene Damage Index Score: 2.15; 39.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARHGEF33 Gene

Disorders for ARHGEF33 Gene

Relevant External Links for ARHGEF33

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for ARHGEF33 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF33 Gene

Publications for ARHGEF33 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for ARHGEF33 Gene

Sources for ARHGEF33 Gene

Loading form....