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Aliases for ARHGEF3 Gene

Aliases for ARHGEF3 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 3 2 3
  • XPLN 2 3 4 6
  • Exchange Factor Found In Platelets And Leukemic And Neuronal Tissues 2 4
  • RhoGEF Protein 2 3
  • Exchange Factor Found In Platelets And Leukemic And Neuronal Tissues, XPLN 3
  • Rho Guanine Nucleotide Exchange Factor 3 3
  • 59.8 KDA Protein 3
  • GEF3 3
  • STA3 3

External Ids for ARHGEF3 Gene

Previous GeneCards Identifiers for ARHGEF3 Gene

  • GC03M055636
  • GC03M056119
  • GC03M056616
  • GC03M056718

Summaries for ARHGEF3 Gene

Entrez Gene Summary for ARHGEF3 Gene

  • Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF3 Gene

ARHGEF3 (Rho Guanine Nucleotide Exchange Factor (GEF) 3) is a Protein Coding gene. Diseases associated with ARHGEF3 include osteoporosis. Among its related pathways are Signaling by FGFR and RhoGDI Pathway. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF11.

UniProtKB/Swiss-Prot for ARHGEF3 Gene

  • Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.

Gene Wiki entry for ARHGEF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF3 Gene

Genomics for ARHGEF3 Gene

Regulatory Elements for ARHGEF3 Gene

Genomic Location for ARHGEF3 Gene

56,727,418 bp from pter
57,079,329 bp from pter
351,912 bases
Minus strand

Genomic View for ARHGEF3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF3 Gene

Proteins for ARHGEF3 Gene

  • Protein details for ARHGEF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 3
    Protein Accession:
    Secondary Accessions:
    • A8K5U7
    • Q4FZB6
    • Q4QQI5
    • Q4QQQ0
    • Q59F00
    • Q6NUN3
    • Q7Z4U2
    • Q7Z5T2
    • Q9H7T4

    Protein attributes for ARHGEF3 Gene

    526 amino acids
    Molecular mass:
    59783 Da
    Quaternary structure:
    • Interacts with RHOA and RHOB
    • Sequence=AAH68513.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14891.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92898.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF3 Gene


neXtProt entry for ARHGEF3 Gene

Proteomics data for ARHGEF3 Gene at MOPED

Post-translational modifications for ARHGEF3 Gene

  • Ubiquitination at Lys249
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGEF3 Gene

Domains for ARHGEF3 Gene

Gene Families for ARHGEF3 Gene

  • ARHGEF :Rho guanine nucleotide exchange factors

Protein Domains for ARHGEF3 Gene

Suggested Antigen Peptide Sequences for ARHGEF3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9NR81
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with ARHGEF3: view

Function for ARHGEF3 Gene

Molecular function for ARHGEF3 Gene

UniProtKB/Swiss-Prot Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.

Gene Ontology (GO) - Molecular Function for ARHGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARHGEF3: view

Phenotypes for ARHGEF3 Gene

GenomeRNAi human phenotypes for ARHGEF3:
genes like me logo Genes that share phenotypes with ARHGEF3: view

miRNA for ARHGEF3 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGEF3 Gene

Localization for ARHGEF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF3 Gene


Subcellular locations from

Jensen Localization Image for ARHGEF3 Gene COMPARTMENTS Subcellular localization image for ARHGEF3 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ARHGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGEF3: view

Pathways for ARHGEF3 Gene

genes like me logo Genes that share pathways with ARHGEF3: view

Gene Ontology (GO) - Biological Process for ARHGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007266 Rho protein signal transduction TAS 10873612
GO:0035023 regulation of Rho protein signal transduction --
GO:0035556 intracellular signal transduction --
GO:0043065 positive regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with ARHGEF3: view

Compounds for ARHGEF3 Gene

(3) HMDB Compounds for ARHGEF3 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP
genes like me logo Genes that share compounds with ARHGEF3: view

Transcripts for ARHGEF3 Gene

Unigene Clusters for ARHGEF3 Gene

Rho guanine nucleotide exchange factor (GEF) 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: -
SP4: - -

Relevant External Links for ARHGEF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGEF3 Gene

mRNA expression in normal human tissues for ARHGEF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGEF3 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF3 Gene Hs.476402

mRNA Expression by UniProt/SwissProt for ARHGEF3 Gene

Tissue specificity: Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.
genes like me logo Genes that share expressions with ARHGEF3: view

No data available for mRNA differential expression in normal tissues for ARHGEF3 Gene

Orthologs for ARHGEF3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGEF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGEF3 35
  • 99.62 (n)
  • 100 (a)
  • 100 (a)
(Bos Taurus)
Mammalia ARHGEF3 35
  • 91.51 (n)
  • 96.77 (a)
  • 92 (a)
(Canis familiaris)
Mammalia ARHGEF3 36
  • 84 (a)
(Mus musculus)
Mammalia Arhgef3 35
  • 85.82 (n)
  • 92.07 (a)
Arhgef3 16
Arhgef3 36
  • 93 (a)
(Monodelphis domestica)
Mammalia ARHGEF3 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 87 (a)
-- 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Arhgef3 35
  • 88.15 (n)
  • 94.07 (a)
(Gallus gallus)
Aves ARHGEF3 35
  • 79.07 (n)
  • 87.4 (a)
  • 83 (a)
(Anolis carolinensis)
Reptilia ARHGEF3 36
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef3 35
  • 74.27 (n)
  • 81.99 (a)
(Danio rerio)
Actinopterygii arhgef3 35
  • 70.89 (n)
  • 79 (a)
arhgef3 36
  • 72 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROM1 36
  • 8 (a)
ROM2 36
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
Species with no ortholog for ARHGEF3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF3 Gene

Gene Tree for ARHGEF3 (if available)
Gene Tree for ARHGEF3 (if available)

Paralogs for ARHGEF3 Gene

Selected SIMAP similar genes for ARHGEF3 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ARHGEF3: view

Variants for ARHGEF3 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs808 -- 56,727,622(+) CACCA(A/G)TAAAG utr-variant-3-prime
rs6978 -- 56,727,687(-) CAAGT(C/T)GTTAT utr-variant-3-prime
rs734651 -- 56,996,088(+) TTTAA(C/T)CCCCA intron-variant
rs752465 -- 57,037,032(-) AGACC(A/G)GCACT intron-variant, upstream-variant-2KB
rs752466 -- 57,037,001(-) CTCCC(C/T)TAAAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF3 Gene

Variant ID Type Subtype PubMed ID
nsv507095 CNV Insertion 20534489
nsv512803 CNV Insertion 21212237
esv1591931 CNV Insertion 17803354
esv2670903 CNV Deletion 23128226
nsv876818 CNV Gain 21882294
nsv523538 CNV Loss 19592680
esv2666798 CNV Deletion 23128226
nsv515842 CNV Loss 19592680
esv272491 CNV Insertion 20981092
nsv509827 CNV Loss 20534489
esv2666251 CNV Deletion 23128226
esv2725308 CNV Deletion 23290073
esv2660634 CNV Deletion 23128226
esv2676065 CNV Deletion 23128226
esv1700976 CNV Insertion 17803354
nsv876819 CNV Gain 21882294

Relevant External Links for ARHGEF3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF3 Gene

Disorders for ARHGEF3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for ARHGEF3 Gene including...

Search for ARHGEF3 Gene in MalaCards »

Relevant External Links for ARHGEF3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ARHGEF3: view

No data available for UniProtKB/Swiss-Prot for ARHGEF3 Gene

Publications for ARHGEF3 Gene

  1. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PMID: 12221096) Arthur W.T. … Wennerberg K. (J. Biol. Chem. 2002) 3 4 23
  2. Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22. (PMID: 10873612) Thiesen S. … Nothwang H.G. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  3. Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women. (PMID: 19727905) Li G.H. … Huang Q.Y. (Osteoporos Int 2010) 3 48
  4. A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium. (PMID: 19820697) Soranzo N. … Gieger C. (Nat. Genet. 2009) 3 48
  5. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 48

Products for ARHGEF3 Gene

Sources for ARHGEF3 Gene

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