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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

ARHGEF3 Gene

protein-coding GIFtS: 60
GCID: GC03M056736

Rho guanine nucleotide exchange factor (GEF) 3

Explore 11 diseases affiliated with
ARHGEF3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 3¹ ²		59.8 KDA Protein²
XPLN¹ ² ³ ⁵		Exchange Factor Found In Platelets And Leukemic And Neuronal Tissues, XPLN²
GEF3¹ ²		Rho Guanine Nucleotide Exchange Factor 3²
STA3¹ ²		RhoGEF Protein²
DKFZP434F2429¹		Exchange Factor Found In Platelets And Leukemic And Neuronal Tissues³

External Ids:	HGNC: 683¹	Entrez Gene: 50650²	Ensembl: ENSG00000163947⁷	OMIM: 612115⁵	UniProtKB: Q9NR81³

Export aliases for ARHGEF3 gene to outside databases

Previous GC identifers: GC03M055636 GC03M056119 GC03M056616 GC03M056718

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGEF3:

Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated

by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate

the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide

exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have

a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the

determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis.

Alternatively spliced transcript variants encoding different isoforms have been found for this gene. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARHG3_HUMAN, Q9NR81

Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases

Gene Wiki entry for ARHGEF3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000003.11 NC_018914.1 NT_022517.18

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the ARHGEF3 gene promoter:
GR Sox5 p53 FOXD1 E47 CREB PPAR-alpha deltaCREB ARP-1 GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARHGEF3 promoter sequence

Search SABiosciences Chromatin IP Primers for ARHGEF3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p14.3 Ensembl cytogenetic band: 3p14.3 HGNC cytogenetic band: 3p14.3

ARHGEF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF3 gene location

GeneLoc information about chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M056736: view genomic region (about GC identifiers)

Start:	56,761,446 bp from pter	End:	57,113,357 bp from pter
Size:	351,912 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: ARHG3_HUMAN, Q9NR81 (See protein sequence)

Recommended Name: Rho guanine nucleotide exchange factor 3

Size: 526 amino acids; 59783 Da

Subunit: Interacts with RHOA and RHOB

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=AAH68513.1; Type=Erroneous initiation; Sequence=BAB14891.1; Type=Erroneous initiation;

Sequence=BAD92898.1; Type=Erroneous initiation;

Secondary accessions: A8K5U7 Q4FZB6 Q4QQI5 Q4QQQ0 Q59F00 Q6NUN3 Q7Z4U2 Q7Z5T2 Q9H7T4

Alternative splicing: 4 isoforms: Q9NR81-1 Q9NR81-2 Q9NR81-3 Q9NR81-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGEF3: NX_Q9NR81

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NR81

ARHGEF3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001122087.1 NP_001122088.1 NP_062455.1

ENSEMBL proteins:

ENSP00000296315 ENSP00000341071 ENSP00000410922 ENSP00000417810 ENSP00000420420

ENSP00000418826 ENSP00000417986 ENSP00000417087 ENSP00000420402 ENSP00000418984

ENSP00000418469 ENSP00000420633

Reactome Protein details: Q9NR81
Human Recombinant Protein Products:

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	Browse Sino Biological Recombinant Proteins
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	Uscn Proteins for ARHGEF3

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	--
GO:0005829	cytosol	TAS	--

ARHGEF3 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for ARHGEF3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ARHGEF3 for domains About GeneDecksing

5 InterPro domains/families:

IPR001331 GDS_CDC24_CS

IPR000219 DH-domain

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

IPR015721 RhoGEF-like

Graphical View of Domain Structure for InterPro Entry Q9NR81

ProtoNet protein and cluster: Q9NR81

2 Blocks protein families:

IPB000219 DH domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: ARHG3_HUMAN, Q9NR81

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: ARHG3_HUMAN, Q9NR81

Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases

miRNA Products:		miRTarBase miRNAs that target ARHGEF3: hsa-mir-373 (MIRT002512), hsa-mir-138 (MIRT000493)

		OriGene 3'-UTR Clone (see all 3): ARHGEF3 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGEF3
		8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGEF3 (see all 99):
		hsa-miR-548j hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-199a-3p hsa-miR-106a hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: ARHGEF3 3' UTR sequence

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Gene Editing
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DNA2.0 Custom Protein Engineering Service for ARHGEF3

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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for ARHGEF3
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF3

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005089	Rho guanyl-nucleotide exchange factor activity	IEA	--
GO:0005543	phospholipid binding	IEA	--

ARHGEF3 for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for ARHGEF3:

Decreased focal adhesion (FA)

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/19 super-pathways (see all 19) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell death signalling via NRAGE, NRIF and NADE

Cell death signalling via NRAGE, NRIF and NADE	1.00	G alpha (12/13) signalling events	0.39
NRAGE signals death through JNK	0.74	Rho GTPase cycle	0.25
p75 NTR receptor-mediated signalling	0.73	Signaling by Rho GTPases	0.25

G-protein signaling_RhoA regulation pathway

	G-protein signaling_RhoA regulation pathway	1.00			G-protein signaling_RhoB regulation pathway	0.16
	G-protein signaling RhoA regulation pathway	1.00			G-protein signaling RhoB regulation pathway	0.16

GPCR Pathway

	GPCR Pathway	1.00			Breast Cancer Regulation by Stathmin1	0.58
	Ras Pathway	0.62			Pancreatic Adenocarcinoma	0.55

G-AlphaQ Signaling

	G-AlphaQ Signaling	1.00			Thrombin Signaling	0.40
	G-AlphaI Signaling	0.47

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for ARHGEF3

	G-protein signaling RhoB regulation pathway
	G-protein signaling RhoA regulation pathway

5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGEF3 (see all 21)

	RhoA Pathway
	Guidance Cues and Growth Cone Motility
	Molecular Mechanisms of Cancer
	Interferon Pathway
	G-AlphaI Signaling

2 GeneGo (Thomson Reuters) Pathways for ARHGEF3

	G-protein signaling RhoB regulation pathway
	G-protein signaling RhoA regulation pathway

1 BioSystems Pathway for ARHGEF3

Regulation of RhoA activity

5/10 Reactome Pathways for ARHGEF3 (see all 10)

	GPCR downstream signaling
	Signaling by Rho GTPases
	G alpha (12/13) signalling events
	Cell death signalling via NRAGE, NRIF and NADE
	Signaling by GPCR

ARHGEF3 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for ARHGEF3

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for ARHGEF3 (Q9NR81³ ENSP00000341071⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RHOA	P61586³, ENSP00000400175⁴	I2D: score=2 STRING: ENSP00000400175
RHOB	P62745³, ENSP00000272233⁴	I2D: score=2 STRING: ENSP00000272233
SHC1	P29353³	I2D: score=2
RASL10B	ENSP00000268864⁴	STRING: ENSP00000268864
SUMO4	ENSP00000318635⁴	STRING: ENSP00000318635

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	TAS	--
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0007266	Rho protein signal transduction	TAS	10873612
GO:0035023	regulation of Rho protein signal transduction	IEA	--
GO:0035556	intracellular signal transduction	--	--

ARHGEF3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for ARHGEF3

3 HMDB Compounds for ARHGEF3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine diphosphate	5'-GDP (see all 10)	146-91-8	--
Guanosine monophosphate	5'-GMP (see all 14)	85-32-5	--
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about ARHGEF3 / ARHG3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for ARHGEF3 gene (3 alternative transcripts):

NM_001128615.1 NM_001128616.1 NM_019555.2

Unigene Cluster for ARHGEF3:

Rho guanine nucleotide exchange factor (GEF) 3

Hs.476402 [show with all ESTs]

Unigene Representative Sequence: NM_001128616

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000296315(uc003dig.2 uc010hmy.1) ENST00000338458(uc011bew.1 uc003dih.2)

ENST00000413728(uc011bev.1 uc003dif.2) ENST00000465659 ENST00000496106

ENST00000497267 ENST00000495373(uc003dii.2) ENST00000468727 ENST00000473779

ENST00000481422 ENST00000498517 ENST00000477833 ENST00000477440 ENST00000468466

ENST00000486829

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		8/99 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGEF3 (see all 99):
		hsa-miR-548j hsa-miR-3607-3p hsa-miR-520e hsa-miR-520f hsa-miR-300 hsa-miR-199a-3p hsa-miR-106a hsa-miR-30d

		SwitchGear 3'UTR luciferase reporter plasmid: ARHGEF3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

AB209661.1 AF249744.1 AF433662.1 AK024340.1 AK225688.1 AK291412.1 AK293864.1 AK300045.1

AK302493.1 AK308178.1 AL136832.1 BC022249.1 BC054345.1 BC068513.1 BC098122.1 BC098272.1

BC099715.1 BC104723.1

14 DOTS entries:

DT.416526 DT.100723381 DT.97820571 DT.91763225 DT.100705297 DT.100767802 DT.95349033 DT.95363358

DT.100682932 DT.120919768 DT.120919779 DT.95247862 DT.100689594 DT.100694817

24/205 AceView cDNA sequences (see all 205):

NM_019555 CD677532 AI022899 BQ189061 AA195613 AL524994 BU507700 AA349948

BP344091 BM851286 AA323861 AA234335 AW518700 BC054345 AA830261 BX111634

AI366951 AA262897 AA887559 CD172348 AI968636 AI025137 CR594043 BM851180

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF3 About this scheme

ExUns:	1	^	2	^	3	^	4a	·	4b	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b
SP1:							-		-		-
SP2:											-
SP3:
SP4:											-										-

ECgene alternative splicing isoforms for ARHGEF3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

ARHGEF3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATGAATTTTT

About this image

ARHGEF3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See ARHGEF3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGEF3

SOURCE GeneReport for Unigene cluster: Hs.476402

UniProtKB/Swiss-Prot: ARHG3_HUMAN, Q9NR81

Tissue specificity: Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are

found in heart and kidney

SABiosciences Custom PCR Arrays for ARHGEF3

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF3 gene from 5/20 species (see all 20) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	ARHGEF3¹	Rho guanine nucleotide exchange factor (GEF) 3	77.67(n) 85.74(a)		416000 NM_001030595.1 NP_001025766.1
lizard (Anolis carolinensis)	Reptilia	ARHGEF3⁶	--	80(a)	1 ↔ 1	2(162745945-162784045)
African clawed frog (Xenopus laevis)	Amphibia	BX849584.1²	--	77.18(n)		BX849584.1
zebrafish (Danio rerio)	Actinopterygii	LOC570228¹	novel protein similar to vertebrate Rho guanine nucleotide more	71.28(n) 79.44(a)		570228 NM_001082868.1 NP_001076337.1
honey bee (Apis mellifera)	Insecta	--	--	25(a)	1 → many	Group1.48(27406-29435)

ENSEMBL Gene Tree for ARHGEF3 (if available)
TreeFam Gene Tree for ARHGEF3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for ARHGEF3 gene

ARHGEF2² ARHGEF11² NET1² ARHGEF1² ARHGEF12² ARHGEF18² AKAP13² ARHGEF28²

1 SIMAP similar gene for ARHGEF3 using alignment to 10 protein entries: ARHG3_HUMAN (see all proteins):

NET1

ARHGEF3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs77636360^1,2	C,F,	--	56760991(+)	`CTTACG/ACCTGT`	3	--	ds500¹		1		WA	118
rs143523822^1,2		--	56761140(+)	`TCCCAC/GTTACT`	3	--	ds500¹		0	--	--	--	--
rs147168065^1,2		--	56761285(+)	`GTTCTA/GTGAAA`	3	--	ds500¹		0	--	--	--	--
rs139442349^1,2		--	56761291(+)	`TGAAAA/GTTTTG`	3	--	ds500¹		0	--	--	--	--
rs149671211^1,2		--	56761344(+)	`TAAAGC/TTTGTA`	3	--	ds500¹		0	--	--	--	--
rs185399282^1,2		--	56761394(+)	`CAGGAA/GCACAG`	3	--	ds500¹		0	--	--	--	--
rs144375677^1,2		--	56761501(+)	`CCATTA/TTACAA`	3	--	ut3¹		0	--	--	--	--
rs148791751^1,2		--	56761513(+)	`AACATG/TCATTT`	3	--	ut3¹		0	--	--	--	--
rs808^1,2	C,F,A,H,	--	56761650(+)	`CACCAA/GTAAAG`	3	--	ut3¹ ese³		28		MN NS EA NA WA	3326
rs7356087^1,2	C,H	--	56761692(+)	`CAGCAG/AGTTCA`	3	--	ut3¹		4		NS EA	420

HapMap Linkage Disequilibrium report for ARHGEF3 (56761446 - 57011446 bp, first 250kb of ARHGEF3)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for ARHGEF3
1 CNV: 51127

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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ARHGEF3 for disorders           About GeneDecksing

OMIM gene information: 612115    OMIM disorders: --

11 diseases for ARHGEF3:    About MalaCards

osteoporosis hypochromic anemia neuronitis rheumatoid arthritis

spasticity arthritis anemia leukemia

breast cancer adenocarcinoma pancreatitis

Human Genome Epidemiology (HuGE) Navigator: ARHGEF3 (7 documents)

Export disorders for ARHGEF3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for ARHGEF3 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with ARHGEF3)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22. (PubMed id 10873612)^{1, 2, 3} Thiesen S.... Nothwang H.G. (2000)
XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PubMed id 12221096)^{1, 2, 9} Arthur W.T.... Wennerberg K. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2} Wiemann S.... Poustka A. (2001)
Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)¹ Udeshi N.D....Carr S.A. (2012)
Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European suscepti bility loci. (PubMed id 21452313)¹ Freudenberg J....Bae S.C. (2011)
New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)¹ Gieger C....Soranzo N. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)¹ Takefuji M....Kaibuchi K. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 50650	HGNC: 683	AceView: ARHGEF3	Ensembl:ENSG00000163947	euGenes: HUgn50650
ECgene: ARHGEF3	H-InvDB: ARHGEF3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for ARHGEF3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for ARHGEF3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for ARHGEF3 gene:
Search GeneIP for patents involving ARHGEF3

GeneCards and IP:
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Rho guanine nucleotide exchange factor (GEF) 3

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Rho guanine nucleotide exchange factor (GEF) 3

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