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Aliases for ARHGEF3 Gene

Aliases for ARHGEF3 Gene

  • Rho Guanine Nucleotide Exchange Factor 3 2 3 5
  • Exchange Factor Found In Platelets And Leukemic And Neuronal Tissues, XPLN 2 3
  • Rho Guanine Nucleotide Exchange Factor (GEF) 3 2 3
  • RhoGEF Protein 2 3
  • XPLN 3 4
  • Exchange Factor Found In Platelets And Leukemic And Neuronal Tissues 4
  • 59.8 KDA Protein 3
  • GEF3 3
  • STA3 3

External Ids for ARHGEF3 Gene

Previous GeneCards Identifiers for ARHGEF3 Gene

  • GC03M055636
  • GC03M056119
  • GC03M056616
  • GC03M056718

Summaries for ARHGEF3 Gene

Entrez Gene Summary for ARHGEF3 Gene

  • Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF3 Gene

ARHGEF3 (Rho Guanine Nucleotide Exchange Factor 3) is a Protein Coding gene. Diseases associated with ARHGEF3 include Osteoporosis. Among its related pathways are Signaling by GPCR and GPCR Pathway. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is NET1.

UniProtKB/Swiss-Prot for ARHGEF3 Gene

  • Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.

Gene Wiki entry for ARHGEF3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF3 Gene

Genomics for ARHGEF3 Gene

Regulatory Elements for ARHGEF3 Gene

Enhancers for ARHGEF3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F056921 1.6 FANTOM5 Ensembl ENCODE 12.2 +153.0 152977 10.1 PKNOX1 MLX ARID4B ZNF48 SLC30A9 ZNF143 SP5 JUNB MXD4 TBX21 FAM208A ARHGEF3 CCDC66 ARHGEF3-AS1 GC03M056906
GH03F056752 1.5 FANTOM5 Ensembl ENCODE 12.6 +323.0 322950 7.9 HDGF PKNOX1 WRNIP1 ZNF121 FOS JUNB TBX21 KAT8 NFIL3 MIER3 FAM208A ARHGEF3 CCDC66 GC03P056724 GC03M056906
GH03F056794 1.1 ENCODE 17 +280.6 280629 8.3 HDGF PKNOX1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 ARHGEF3 CCDC66 GC03P056724 GC03M056906
GH03F056775 1.7 FANTOM5 Ensembl ENCODE 8.6 +295.2 295225 17.5 HDGF PKNOX1 MLX ARID4B FEZF1 DMAP1 YY1 CBX5 ZNF143 KLF7 FAM208A ARHGEF3 CCDC66 GC03P056724 GC03M056906
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGEF3 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGEF3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for ARHGEF3 Gene

56,727,418 bp from pter
57,079,329 bp from pter
351,912 bases
Minus strand

Genomic View for ARHGEF3 Gene

Genes around ARHGEF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF3 Gene

Proteins for ARHGEF3 Gene

  • Protein details for ARHGEF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 3
    Protein Accession:
    Secondary Accessions:
    • A8K5U7
    • Q4FZB6
    • Q4QQI5
    • Q4QQQ0
    • Q59F00
    • Q6NUN3
    • Q7Z4U2
    • Q7Z5T2
    • Q9H7T4

    Protein attributes for ARHGEF3 Gene

    526 amino acids
    Molecular mass:
    59783 Da
    Quaternary structure:
    • Interacts with RHOA and RHOB.
    • Sequence=AAH68513.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14891.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAD92898.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF3 Gene


neXtProt entry for ARHGEF3 Gene

Post-translational modifications for ARHGEF3 Gene

  • Ubiquitination at Lys 249
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGEF3 Gene

Domains & Families for ARHGEF3 Gene

Gene Families for ARHGEF3 Gene

Protein Domains for ARHGEF3 Gene

Suggested Antigen Peptide Sequences for ARHGEF3 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with ARHGEF3: view

Function for ARHGEF3 Gene

Molecular function for ARHGEF3 Gene

UniProtKB/Swiss-Prot Function:
Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.

Gene Ontology (GO) - Molecular Function for ARHGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARHGEF3: view
genes like me logo Genes that share phenotypes with ARHGEF3: view

Animal Model Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF3 Gene

Localization for ARHGEF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF3 gene
Compartment Confidence
cytosol 5
nucleus 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ARHGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA,IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGEF3: view

Pathways & Interactions for ARHGEF3 Gene

genes like me logo Genes that share pathways with ARHGEF3: view

Gene Ontology (GO) - Biological Process for ARHGEF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007266 Rho protein signal transduction TAS 10873612
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0035556 intracellular signal transduction IEA --
GO:0043065 positive regulation of apoptotic process TAS --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGEF3: view

No data available for SIGNOR curated interactions for ARHGEF3 Gene

Drugs & Compounds for ARHGEF3 Gene

(3) Drugs for ARHGEF3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGEF3: view

Transcripts for ARHGEF3 Gene

Unigene Clusters for ARHGEF3 Gene

Rho guanine nucleotide exchange factor (GEF) 3:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - - -
SP2: -
SP4: - -

Relevant External Links for ARHGEF3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGEF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGEF3 Gene

This gene is overexpressed in Plasma (58.5) and Peripheral blood mononuclear cells (10.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGEF3 Gene

Protein tissue co-expression partners for ARHGEF3 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF3 Gene:


SOURCE GeneReport for Unigene cluster for ARHGEF3 Gene:


mRNA Expression by UniProt/SwissProt for ARHGEF3 Gene:

Tissue specificity: Widely expressed. Highest levels are found in adult brain and skeletal muscle. Lower levels are found in heart and kidney.
genes like me logo Genes that share expression patterns with ARHGEF3: view

Primer Products

No data available for mRNA differential expression in normal tissues for ARHGEF3 Gene

Orthologs for ARHGEF3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGEF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGEF3 34 35
  • 99.62 (n)
(Bos Taurus)
Mammalia ARHGEF3 34 35
  • 91.51 (n)
(Rattus norvegicus)
Mammalia Arhgef3 34
  • 88.15 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 87 (a)
-- 35
  • 87 (a)
(Mus musculus)
Mammalia Arhgef3 34 16 35
  • 85.82 (n)
(Canis familiaris)
Mammalia ARHGEF3 35
  • 84 (a)
(Monodelphis domestica)
Mammalia ARHGEF3 35
  • 72 (a)
(Gallus gallus)
Aves ARHGEF3 34 35
  • 79.07 (n)
(Anolis carolinensis)
Reptilia ARHGEF3 35
  • 82 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef3 34
  • 74.27 (n)
(Danio rerio)
Actinopterygii arhgef3 34 35
  • 70.89 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROM1 35
  • 8 (a)
ROM2 35
  • 7 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
Species where no ortholog for ARHGEF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF3 Gene

Gene Tree for ARHGEF3 (if available)
Gene Tree for ARHGEF3 (if available)

Paralogs for ARHGEF3 Gene

Paralogs for ARHGEF3 Gene

(1) SIMAP similar genes for ARHGEF3 Gene using alignment to 10 proteins:

genes like me logo Genes that share paralogs with ARHGEF3: view

Variants for ARHGEF3 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10048929 -- 57,078,490(+) AAAGC(A/C)CAAGG intron-variant, upstream-variant-2KB
rs10049269 -- 56,883,681(+) TGCAC(C/T)CCCAG intron-variant
rs1006156 -- 57,047,802(-) CAGCT(C/G)CCCTG intron-variant
rs1006411 -- 57,046,056(+) AGAAG(C/T)CCAAT intron-variant
rs1009118 -- 56,729,497(-) CAGTT(C/T)TGTGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF3 Gene

Variant ID Type Subtype PubMed ID
nsv590363 CNV loss 21841781
nsv523538 CNV loss 19592680
nsv515842 CNV loss 19592680
nsv512803 CNV insertion 21212237
nsv509827 OTHER sequence alteration 20534489
nsv507095 OTHER sequence alteration 20534489
nsv1160943 CNV duplication 26073780
nsv1139118 CNV deletion 24896259
nsv1139117 CNV deletion 24896259
nsv1139116 CNV deletion 24896259
nsv1116990 CNV deletion 24896259
nsv1074596 CNV deletion 25765185
esv3596223 CNV loss 21293372
esv3596222 CNV loss 21293372
esv3596221 CNV loss 21293372
esv3596219 CNV loss 21293372
esv3596218 CNV loss 21293372
esv3584503 CNV gain 24956385
esv3568765 CNV loss 25503493
esv3568763 CNV loss 25503493
esv3561922 CNV deletion 23714750
esv3392720 CNV duplication 20981092
esv3361524 CNV insertion 20981092
esv3308217 CNV mobile element insertion 20981092
esv2725308 CNV deletion 23290073
esv2676065 CNV deletion 23128226
esv2670903 CNV deletion 23128226
esv2666798 CNV deletion 23128226
esv2666251 CNV deletion 23128226
esv2660634 CNV deletion 23128226
esv1700976 CNV insertion 17803354
esv1591931 CNV insertion 17803354
dgv1377e212 CNV gain 25503493

Variation tolerance for ARHGEF3 Gene

Residual Variation Intolerance Score: 52.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.31; 90.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF3 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF3 Gene

Disorders for ARHGEF3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGEF3 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
  • osteoporosis, postmenopausal, susceptibility
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGEF3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARHGEF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGEF3 Gene

Publications for ARHGEF3 Gene

  1. XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC. (PMID: 12221096) Arthur W.T. … Wennerberg K. (J. Biol. Chem. 2002) 3 4 22 64
  2. Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22. (PMID: 10873612) Thiesen S. … Nothwang H.G. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 64
  3. Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci. (PMID: 21452313) Freudenberg J. … Bae S.C. (Arthritis Rheum. 2011) 3 46 64
  4. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 3 46 64
  5. Common variants in FLNB/CRTAP, not ARHGEF3 at 3p, are associated with osteoporosis in southern Chinese women. (PMID: 19727905) Li G.H. … Huang Q.Y. (Osteoporos Int 2010) 3 46 64

Products for ARHGEF3 Gene

Sources for ARHGEF3 Gene

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