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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGEF28 Gene

protein-coding   GIFtS: 42
GCID: GC05P072921

Rho Guanine Nucleotide Exchange Factor (GEF) 28

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 281 2     Rho Guanine Nucleotide Exchange Factor 282
RGNEF2 3 5     Rho Interacting Protein 22
190 KDa Guanine Nucleotide Exchange Factor2 3     Rho-Guanine Nucleotide Exchange Factor2
p190-RhoGEF2 3     KIAA19983
p190RHOGEF2 5     p190RhoGEF3
RIP22     Rho Guanine Nucleotide Exchange Factor3

External Ids:    HGNC: 303221   Entrez Gene: 642832   Ensembl: ENSG000002149447   OMIM: 6127905   UniProtKB: Q8N1W13   

Export aliases for ARHGEF28 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGEF28 Gene:
This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts
with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral
sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.(provided by
RefSeq, Apr 2010)

GeneCards Summary for ARHGEF28 Gene: 
ARHGEF28 (Rho guanine nucleotide exchange factor (GEF) 28) is a protein-coding gene. Diseases associated with ARHGEF28 include lateral sclerosis, and amyotrophic lateral sclerosis. GO annotations related to this gene include RNA binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF2.

UniProtKB/Swiss-Prot: ARG28_HUMAN, Q8N1W1
Function: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream
of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic
morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May
regulate NEFL expression and aggregation and play a role in apoptosis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006713.15  NC_018916.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ARHGEF28
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ARHGEF28

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.2

ARHGEF28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF28 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P072921:  view genomic region     (about GC identifiers)

Start:
72,921,983 bp from pter      End:
73,237,818 bp from pter
Size:
315,836 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARG28_HUMAN, Q8N1W1 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 28  
Size: 1705 amino acids; 191891 Da
Subunit: Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA.
Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2/FAK1. Interacts with NEFL (By
similarity). Interacts with CTNND2; prevents interaction with RHOA
Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with the
microtubule radial and cortical systems (By similarity)
Sequence caution: Sequence=AAH12946.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15243.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC02707.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B2RXG7 B4E3K4 B5MDA3 B7ZW32 E9PC75 Q8NCM7 Q96E37 Q9H6L3 Q9H6W0
Alternative splicing: 6 isoforms:  Q8N1W1-1   Q8N1W1-2   Q8N1W1-3   Q8N1W1-4   Q8N1W1-5   Q8N1W1-6   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for ARHGEF28: NX_Q8N1W1

Explore proteomics data for ARHGEF28 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine upon stimulation of cells by laminin (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N1W1

  • ARHGEF28 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGEF28 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001073948.2  NP_001171164.1  NP_001231293.1  

    ENSEMBL proteins: 
     ENSP00000296794   ENSP00000421859   ENSP00000411459   ENSP00000412175   ENSP00000296799  
     ENSP00000421081   ENSP00000441913   ENSP00000441436   ENSP00000287898  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IEA--
    GO:0015630microtubule cytoskeleton IDA--

    ARHGEF28 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5 InterPro protein domains:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR011993 PH_like_dom
     IPR015721 RhoGEF-like

    Graphical View of Domain Structure for InterPro Entry Q8N1W1

    ProtoNet protein and cluster: Q8N1W1

    1 Blocks protein domain: IPB000219 DH domain

    UniProtKB/Swiss-Prot: ARG28_HUMAN, Q8N1W1
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger


    ARHGEF28 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARG28_HUMAN, Q8N1W1
    Function: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream
    of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic
    morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May
    regulate NEFL expression and aggregation and play a role in apoptosis (By similarity)

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0046872metal ion binding IEA--
         
    ARHGEF28 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGEF28 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Regulation of RhoA activity
    Regulation of RhoA activity
    2Signaling events mediated by focal adhesion kinase
    Signaling events mediated by focal adhesion kinase


    2 BioSystems Pathways for ARHGEF28
        Regulation of RhoA activity
    Signaling events mediated by focal adhesion kinase


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGEF28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/13 Interacting proteins for ARHGEF28 (Q8N1W12, 3 ENSP000002967944) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583, ENSP000002643354I2D: score=1 STRING: ENSP00000264335
    YWHAHQ049173, ENSP000002489754I2D: score=1 STRING: ENSP00000248975
    GNA12Q031133, ENSP000002753644I2D: score=1 STRING: ENSP00000275364
    GNA13Q143443, ENSP000004007174I2D: score=1 STRING: ENSP00000400717
    RHOBP627453I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0021955central nervous system neuron axonogenesis ----
    GO:0030154cell differentiation IEA--
    GO:0035023regulation of Rho protein signal transduction IEA--
    GO:0035556intracellular signal transduction IEA--
    GO:0060052neurofilament cytoskeleton organization ----

    ARHGEF28 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGEF28 (ARG28)

    Search CenterWatch for drugs/clinical trials and news about ARHGEF28 / ARG28

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGEF28 gene (3 alternative transcripts): 
    NM_001080479.2  NM_001177693.1  NM_001244364.1  

    Unigene Cluster for ARHGEF28:

    Rho guanine nucleotide exchange factor (GEF) 28
    Hs.482521  [show with all ESTs]
    Unigene Representative Sequence: NM_001080479
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296794(uc003kcy.1 uc021yam.1) ENST00000509848 ENST00000437974
    ENST00000426542(uc011csr.2 uc003kcz.4) ENST00000510131 ENST00000296799
    ENST00000513841 ENST00000506334 ENST00000510312 ENST00000512883 ENST00000504003
    ENST00000503341 ENST00000545377(uc010izf.3) ENST00000513042(uc011csq.2)
    ENST00000287898(uc003kda.4)
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    Additional mRNA sequence: 

    AK025470.1 AK025816.1 AK094713.1 AK304761.1 BC012946.1 BC157846.1 BC171850.1 

    7 DOTS entries:

    DT.211468  DT.86838280  DT.91911576  DT.100692962  DT.91714610  DT.91990191  DT.100026510 

    24/115 AceView cDNA sequences (see all 115):

    AK025816 BQ647718 BQ649621 AK094713 AB082529 CN478799 BM772790 BQ774189 
    AA320016 BM739158 AI298956 BQ028851 AI392766 BP336790 AI393196 BM795008 
    BM794730 AA707026 AK129761 BU190155 AA939006 BU620578 BE669495 H89562 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGEF28 expression in normal human tissues (normalized intensities)      ARHGEF28 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    ARHGEF28 Expression
    About this image


    ARHGEF28 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 3 entries
             autonomic/sympathetic/ganglion   
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
     
     Neural Tube (Nervous System)
             Mesencephalic Floor Plate
     
     Brain (Nervous System)
             ca1 region hippocampus   

    See ARHGEF28 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGEF28

    SOURCE GeneReport for Unigene cluster: Hs.482521
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGEF28 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef285
    Rgnef1
    Rho-guanine nucleotide exchange factor1, 5 81.88(n)1
    81.15(a)1
      13 (51.60 cM)5
    1105961  NM_012026.21  NP_036156.21 
     978985955 
    chicken
    (Gallus gallus)
    Aves LOC4272011 rho-guanine nucleotide exchange factor-like 67.92(n)
    62.97(a)
      427201  XM_424789.3  XP_424789.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF286
    Rho guanine nucleotide exchange factor (GEF) 28
    53(a)
    1 ↔ 1
    2(15680921-15839990)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.91592 Transcribed sequence with weak similarity to protein more 75.79(n)    BX683644.1 
    zebrafish
    (Danio rerio)
    Actinopterygii rgnef1 Rho-guanine nucleotide exchange factor 52(n)
    44.57(a)
      559941  XM_683336.5  XP_688428.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101886
    --
    17(a)
    1 → many
    2L(19502335-19508760)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ROM16
    ROM26
    GDP/GTP exchange protein (GEP) for Rho1p; mutation...
    GDP/GTP exchange factor (GEF) for Rho1p and Rho2p;...
    12(a)
    11(a)
    many ↔ many
    many ↔ many
    VII(627806-631273)
    XII(862714-866784)


    ENSEMBL Gene Tree for ARHGEF28 (if available)
    TreeFam Gene Tree for ARHGEF28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGEF28 gene
    ARHGEF22  ARHGEF122  ARHGEF112  AKAP132  ARHGEF182  ARHGEF12  ENSG000002688612  
    4 SIMAP similar genes for ARHGEF28 using alignment to 3 protein entries:     ARG28_HUMAN (see all proteins):
    AKAP13    ARHGEF18    ARHGEF2    ARHGEF1

    ARHGEF28 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARHGEF28
    PGOHUM00000237693


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/6601 SNPs in ARHGEF28 are shown (see all 6601)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs670772981,2
    C--68195220(+) AGCAG-/TTTCTA 2 -- int10--------
    rs1832824341,2
    --68242741(+) TATATA/GTATAT 2 -- int10--------
    rs1405500111,2
    C--68242966(+) ACCAC-/GAGTGAT 2 -- int10--------
    rs802288121,2
    C--68249657(+) TTTTT-/TCAGAA 2 -- int10--------
    rs1496225581,2
    C--68256200(+) TTTAT-/TTTA  
            
    TTTAT
    2 -- int10--------
    rs113823681,2
    C--68258609(+) TAATTA/-TTTCT 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs678401071,2
    C--68258610(+) AATTT-/ATTCTT 2 -- int10--------
    rs339327321,2
    C--68260471(+) CTTAA-/GGAATT 2 -- int10--------
    rs1480726181,2
    C--68269522(+) TGGGA-/CCCCCC 2 -- int10--------
    rs351578521,2
    C--68283444(+) TTGTT-/AAAAAAAA 2 -- cds10--------

    HapMap Linkage Disequilibrium report for ARHGEF28 (72921983 - 73171983 bp, first 250kb of ARHGEF28)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARHGEF28: --
    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612790    OMIM disorders: --

    3 diseases for ARHGEF28:    About MalaCards
    lateral sclerosis    amyotrophic lateral sclerosis    neuronitis


    ARHGEF28 for disorders           About GeneDecksing


    Export disorders for ARHGEF28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGEF28 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with ARHGEF28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)1, 2 Ohara O.... Koseki H. (2002)
    3. Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. (PubMed id 11058585)1, 3 van Horck F.P....Kranenburg O. (2001)
    4. Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. (PubMed id 10574993)1, 2 Meyer D.... Margolis B. (1999)
    5. Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. (PubMed id 9199174)1, 3 Gebbink M.F....Moolenaar W.H. (1997)
    6. A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis. (PubMed id 23509962)1 Greliche N....Tregouet D.A. (2013)
    7. Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sc lerosis. (PubMed id 22835604)1 Droppelmann C.A....Strong M.J. (2013)
    8. Co-aggregation of RNA binding proteins in ALS spinal m otor neurons: evidence of a common pathogenic mechanism. (PubMed id 22941224)1 Keller B.A....Strong M.J. (2012)
    9. p190RhoGEF (Rgnef) promotes colon carcinoma tumor pro gression via interaction with focal adhesion kinase. (PubMed id 21224360)1 Yu H.G....Schlaepfer D.D. (2011)
    10. Genetic predictors of fibrin D-dimer levels in health y adults. (PubMed id 21502573)1 Smith N.L....Hayward C. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64283 HGNC: 30322 AceView: RGNEF Ensembl:ENSG00000214944 euGenes: HUgn64283
    ECgene: ARHGEF28 H-InvDB: ARHGEF28

    (According to HUGE)
    About This Section
    HUGE: KIAA1998

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGEF28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGEF28 gene:
    Search GeneIP for patents involving ARHGEF28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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