Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGEF28 Gene

protein-coding   GIFtS: 41
GCID: GC05P072921

Rho guanine nucleotide exchange factor (GEF) 28
 Explore 5 diseases affiliated with
ARHGEF28 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARHGEF28    

Aliases
for ARHGEF28 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 281 2     P190RHOGEF1
RGNEF1 2 3 5     Rho Guanine Nucleotide Exchange Factor 282
RIP21 2     Rho Interacting Protein 22
P190RhoGEF1     Rho-Guanine Nucleotide Exchange Factor2
190 KDa Guanine Nucleotide Exchange Factor2 3     KIAA19983
P190-RhoGEF1     Rho Guanine Nucleotide Exchange Factor3

External Ids:    HGNC: 303221   Entrez Gene: 642832   Ensembl: ENSG000002149447   OMIM: 6127905   UniProtKB: Q8N1W13   

Export aliases for ARHGEF28 gene to outside databases


Summaries
for ARHGEF28 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARHGEF28:
This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low
molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis
neurofilament aggregates. Alternate splicing results in multiple transcript variants.(provided by RefSeq, Apr 2010)

UniProtKB/Swiss-Prot: ARG28_HUMAN, Q8N1W1
Function: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of
integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis.
Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression
and aggregation and play a role in apoptosis (By similarity)




Genomic Views
for ARHGEF28 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006713.15  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ARHGEF28
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for ARHGEF28

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q13.2   Ensembl cytogenetic band:  5q13.2   HGNC cytogenetic band: 5q13.2

ARHGEF28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF28 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P072921:  view genomic region     (about GC identifiers)

Start:
 72,921,983 bp from pter      End:
 73,237,818 bp from pter
Size:
 315,836 bases      Orientation:
 plus strand

Proteins
for ARHGEF28 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARG28_HUMAN, Q8N1W1 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 28  
Size: 1705 amino acids; 191891 Da
Subunit: Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA.
Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2/FAK1. Interacts with NEFL (By
similarity). Interacts with CTNND2; prevents interaction with RHOA
Subcellular location: Cytoplasm (By similarity). Cell membrane (By similarity). Note=Colocalizes with the microtubule
radial and cortical systems (By similarity)
Sequence caution: Sequence=AAH12946.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15243.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC02707.1;
Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: B4E3K4 B5MDA3 B7ZW32 Q8NCM7 Q96E37 Q9H6L3 Q9H6W0
Alternative splicing: 5 isoforms:  Q8N1W1-1   Q8N1W1-2   Q8N1W1-3   Q8N1W1-4   Q8N1W1-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGEF28: NX_Q8N1W1

Post-translational modifications:

  • Phosphorylated on tyrosine upon stimulation of cells by laminin (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q8N1W1

    • ARHGEF28 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001073948.2  NP_001171164.1  NP_001231293.1  

    ENSEMBL proteins: 
     ENSP00000296794   ENSP00000421859   ENSP00000411459   ENSP00000412175   ENSP00000296799  
     ENSP00000421081   ENSP00000441913   ENSP00000441436   ENSP00000287898  

    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ARHGEF28 
    GenScript Custom Purified and Recombinant Proteins Services for ARHGEF28
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Uscn

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IEA--
    GO:0015630microtubule cytoskeleton IDA--


    ARHGEF28 for ontologies           About GeneDecksing



    ARHGEF28 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARHGEF28 
    GenScript Custom Superior Antibodies Services for ARHGEF28
    Novus Biologicals ARHGEF28 Antibody
    Search for Antibodies for ARHGEF28 at Abcam  
    Browse Antibodies at Uscn
    Search ThermoFisher Antibodies for ARHGEF28

    Assay Products for ARHGEF28: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGEF28
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn

    Protein Domains /
    Families
    for ARHGEF28 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARHGEF28 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR011993 PH_like_dom
     IPR015721 RhoGEF-like

    Graphical View of Domain Structure for InterPro Entry Q8N1W1

    ProtoNet protein and cluster: Q8N1W1

    1 Blocks protein family: IPB000219 DH domain

    UniProtKB/Swiss-Prot: ARG28_HUMAN, Q8N1W1
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger


    Function
    for ARHGEF28 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARG28_HUMAN, Q8N1W1
    Function: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of
    integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis.
    Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression
    and aggregation and play a role in apoptosis (By similarity)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ARHGEF28
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGEF28
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ARHGEF28
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF28 (see all 6)
    OriGene siRNA: ARHGEF28
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF28

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARHGEF28

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF28 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF28 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for ARHGEF28
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF28 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ARHGEF28
    Search LifeMap BioReagents cell lines for ARHGEF28

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF28

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003723RNA binding IEA--
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0046872metal ion binding IEA--


    ARHGEF28 for ontologies           About GeneDecksing



    Pathways & Interactions
    for ARHGEF28 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Regulation of RhoA activity
    		Regulation of RhoA activity1.00
    2Signaling events mediated by focal adhesion kinase
    		Signaling events mediated by focal adhesion kinase1.00


    2 BioSystems Pathways for ARHGEF28 
        Regulation of RhoA activity
    Signaling events mediated by focal adhesion kinase


    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGEF28

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/13 Interacting proteins for ARHGEF28 (Q8N1W12, 3 ENSP000002967944) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAEP622583, ENSP000002643354I2D: score=1 STRING: ENSP00000264335
    YWHAHQ049173, ENSP000002489754I2D: score=1 STRING: ENSP00000248975
    GNA12Q031133, ENSP000002753644I2D: score=1 STRING: ENSP00000275364
    GNA13Q143443, ENSP000004007174I2D: score=1 STRING: ENSP00000400717
    RHOBP627453I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0021955central nervous system neuron axonogenesis ----
    GO:0030154cell differentiation IEA--
    GO:0035023regulation of Rho protein signal transduction IEA--
    GO:0035556intracellular signal transduction IEA--
    GO:0060052neurofilament cytoskeleton organization ----


    ARHGEF28 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARHGEF28 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGEF28
    Search CenterWatch for drugs/clinical trials and news about ARHGEF28 / ARG28 

    Transcripts
    for ARHGEF28 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARHGEF28 gene (3 alternative transcripts): 
    NM_001080479.2  NM_001177693.1  NM_001244364.1  

    Unigene Cluster for ARHGEF28:

    Rho guanine nucleotide exchange factor (GEF) 28
    Hs.482521  [show with all ESTs]
    Unigene Representative Sequence: NM_001080479
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000296794(uc003kcy.1 uc021yam.1) ENST00000509848 ENST00000437974
    ENST00000426542(uc011csr.2 uc003kcz.4) ENST00000510131 ENST00000296799
    ENST00000513841 ENST00000506334 ENST00000510312 ENST00000512883 ENST00000504003
    ENST00000503341 ENST00000545377(uc010izf.3) ENST00000513042(uc011csq.2)
    ENST00000287898(uc003kda.4)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ARHGEF28
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGEF28
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ARHGEF28
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF28 (see all 6)
    OriGene siRNA: ARHGEF28
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF28
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF28 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF28 (see all 4)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript Custom all cDNA clones Services for ARHGEF28
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF28
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF28 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF28
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat ARHGEF28
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF28
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF28

    Additional cDNA sequence: 

    AK025470.1 AK025816.1 AK094713.1 AK304761.1 BC012946.1 BC157846.1 BC171850.1 

    7 DOTS entries:

    DT.211468  DT.86838280  DT.91911576  DT.100692962  DT.91714610  DT.91990191  DT.100026510 

    24/115 AceView cDNA sequences (see all 115):

    AK025816 AK094713 BQ649621 BQ647718 AB082529 CN478799 AI392766 BM795008 
    AI298956 BQ028851 AI393196 BP336790 BM794730 AA707026 BU190155 AA939006 
    AK129761 BE669495 BU620578 H89562 BG696752 BM739158 BM772790 BQ774189 

    GeneLoc Exon Structure


    Expression
    for ARHGEF28 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    		 See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    ARHGEF28 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARHGEF28 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGEF28

    SOURCE GeneReport for Unigene cluster: Hs.482521
        SABiosciences Custom PCR Arrays for ARHGEF28
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF28
    Browse OriGene validated miRNA SYBR primer pairs
    Search SABiosciences RT2 qPCR Primer Assays in human, mouse, rat ARHGEF28
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF28
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF28
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF28

    Orthologs
    for ARHGEF28 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF28 gene from 6/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Arhgef285
    Rgnef1    		 Rho-guanine nucleotide exchange factor1, 5 81.88(n)1
    81.15(a)1    		   13 (51.60 cM)5
    1105961  NM_012026.21  NP_036156.21 
     978985955 
    chicken
    (Gallus gallus)    		 Aves LOC4272011 rho-guanine nucleotide exchange factor-like 67.92(n)
    62.97(a)    		   427201  XM_424789.3  XP_424789.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ARHGEF286
    		 --
    		 53(a)
    		 1 ↔ 1
    		 2(15706814-15801762)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.91592 Transcribed sequence with weak similarity to protein more 75.79(n)    BX683644.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii rgnef1 Rho-guanine nucleotide exchange factor 52(n)
    44.57(a)    		   559941  XM_683336.5  XP_688428.4 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG101886
    		 --
    		 16(a)
    		 1 → many
    		 2L(19502335-19508760)


    ENSEMBL Gene Tree for ARHGEF28 (if available)
    TreeFam Gene Tree for ARHGEF28 (if available) 

    Paralogs
    for ARHGEF28 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGEF28 gene
    ARHGEF22  ARHGEF32  ARHGEF112  NET12  ARHGEF12  ARHGEF122  ARHGEF182  AKAP132  
    5 SIMAP similar genes for ARHGEF28 using alignment to 4 protein entries:     ARG28_HUMAN (see all proteins):
    RGNEF    ARHGEF18    AKAP13    ARHGEF2    ARHGEF1

    ARHGEF28 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for ARHGEF28
    PGOHUM00000237693


    Genomic Variants
    for ARHGEF28 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/5545 NCBI SNPs in ARHGEF28 are shown (see all 5545)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs9297411,2
    		C,A--68126166(+) tttttC/Tttctt 2 -- us2k10--------
    rs747875951,2
    		C,F,--68126518(+) GCCAGC/TTTCCT 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs731145971,2
    		C,F,--68126810(+) TGCTTT/CGGAGG 2 -- us2k13Minor allele frequency- C:0.20WA 122
    rs30958611,2
    		C,F,--68127576(+) GCGTTC/GCGAGG 2 -- ut513Minor allele frequency- G:0.12NA CSA 124
    rs747311291,2
    		--68129012(+) TTTCAA/GTGTAA 2 -- int11Minor allele frequency- G:0.01NA 120
    rs1137375731,2
    		C,--68129341(+) TTAAAG/-GTAAA 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs768991801,2
    		--68129777(+) TGGTAC/TTGAAC 2 -- int10--------
    rs788987061,2
    		F,--68129913(+) ATCCCC/TCCACC 2 -- int11Minor allele frequency- T:0.08WA 118
    rs803140421,2
    		C,F,--68130127(+) ATTTTT/CCTTGC 2 -- int11Minor allele frequency- C:0.03NA 120
    rs765786341,2
    		--68130368(+) ATTTGC/TTGAAG 2 -- int12Minor allele frequency- T:0.33CSA 3

    HapMap Linkage Disequilibrium report for ARHGEF28 (72921983 - 73171983 bp, first 250kb of ARHGEF28)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARHGEF28: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF28
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGEF28

    Disorders / Diseases
    for ARHGEF28 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARHGEF28 for disorders           About GeneDecksing

    OMIM gene information: 612790    OMIM disorders: --

    5 diseases for ARHGEF28:    About MalaCards
    amyotrophic lateral sclerosis    lateral sclerosis    colon carcinoma    neuronitis
    carcinoma


    Export disorders for ARHGEF28 gene to outside databases

    Publications
    for ARHGEF28 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGEF28 gene, integrated from 9 sources (see all 21):
    (articles sorted by number of sources associating them with ARHGEF28)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)1, 2 Ohara O.... Koseki H. (2002)
    3. Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. (PubMed id 11058585)1, 3 van Horck F.P....Kranenburg O. (2001)
    4. Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. (PubMed id 10574993)1, 2 Meyer D.... Margolis B. (1999)
    5. Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. (PubMed id 9199174)1, 3 Gebbink M.F....Moolenaar W.H. (1997)
    6. Rho guanine nucleotide exchange factor is an NFL mRNA destabilizing factor that forms cytoplasmic inclusions in amyotrophic lateral sc lerosis. (PubMed id 22835604)1 Droppelmann C.A....Strong M.J. (2013)
    7. Co-aggregation of RNA binding proteins in ALS spinal m otor neurons: evidence of a common pathogenic mechanism. (PubMed id 22941224)1 Keller B.A....Strong M.J. (2012)
    8. p190RhoGEF (Rgnef) promotes colon carcinoma tumor pro gression via interaction with focal adhesion kinase. (PubMed id 21224360)1 Yu H.G....Schlaepfer D.D. (2011)
    9. Genetic predictors of fibrin D-dimer levels in health y adults. (PubMed id 21502573)1 Smith N.L....Hayward C. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for ARHGEF28 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ARHGEF28 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 64283 HGNC: 30322 AceView: RGNEF Ensembl:ENSG00000214944 euGenes: HUgn64283
    ECgene: ARHGEF28 H-InvDB: ARHGEF28

    Other Databases showing ARHGEF28 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1998

    Specialized Databases showing ARHGEF28 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for ARHGEF28 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARHGEF28 gene:
    Search GeneIP for patents involving ARHGEF28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ARHGEF28 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   Browse OriGene shRNA RFPs  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF28   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF28  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ARHGEF28   OriGene 3'-UTR Clone for ARHGEF28  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF28   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF28  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARHGEF28   OriGene Custom Protein Services for ARHGEF28  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGEF28
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF28
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF28
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF28
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF28
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF28
     GenScript Custom Purified and Recombinant Proteins Services for ARHGEF28 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for ARHGEF28
     GenScript Custom Assay Services for ARHGEF28 GenScript Custom Superior Antibodies Services for ARHGEF28
     GenScript Custom overexpressing Cell Line Services for ARHGEF28 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for ARHGEF28
     Search Chromatin IP Primers for ARHGEF28
     Search RT2 qPCR Primer Assays in human, mouse, rat ARHGEF28
     Search GNC Networks for ARHGEF28
     SABiosciences Custom PCR Arrays for ARHGEF28
     Search Tocris compounds for ARHGEF28
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARHGEF28 antibodies
     Search for Antibodies for ARHGEF28 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for ARHGEF28
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn
     Search LifeMap BioReagents cell lines for ARHGEF28
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF28
     Browse SwitchGear 3'UTR luciferase reporter plasmids for ARHGEF28
     Browse SwitchGear Promoter luciferase reporter plasmids for ARHGEF28
     Search ThermoFisher Antibodies for ARHGEF28
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF28
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ARHGEF28 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4