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Aliases for ARHGEF28 Gene

Aliases for ARHGEF28 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 28 2 3
  • P190RHOGEF 3 4 6
  • RGNEF 3 4 6
  • 190 KDa Guanine Nucleotide Exchange Factor 3 4
  • P190-RhoGEF 3 4
  • Rho Guanine Nucleotide Exchange Factor 28 3
  • Rho-Guanine Nucleotide Exchange Factor 3
  • Rho Guanine Nucleotide Exchange Factor 4
  • Rho Interacting Protein 2 3
  • KIAA1998 4
  • RIP2 3

External Ids for ARHGEF28 Gene

Previous GeneCards Identifiers for ARHGEF28 Gene

  • GC05P072921

Summaries for ARHGEF28 Gene

Entrez Gene Summary for ARHGEF28 Gene

  • This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

GeneCards Summary for ARHGEF28 Gene

ARHGEF28 (Rho Guanine Nucleotide Exchange Factor (GEF) 28) is a Protein Coding gene. Among its related pathways are Regulation of RhoA activity and Signaling events mediated by focal adhesion kinase. GO annotations related to this gene include RNA binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF11.

UniProtKB/Swiss-Prot for ARHGEF28 Gene

  • Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF28 Gene

Genomics for ARHGEF28 Gene

Genomic Location for ARHGEF28 Gene

Start:
73,626,158 bp from pter
End:
73,941,993 bp from pter
Size:
315,836 bases
Orientation:
Plus strand

Genomic View for ARHGEF28 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF28 Gene

No data available for Regulatory Elements for ARHGEF28 Gene

Proteins for ARHGEF28 Gene

  • Protein details for ARHGEF28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1W1-ARG28_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 28
    Protein Accession:
    Q8N1W1
    Secondary Accessions:
    • B2RXG7
    • B4E3K4
    • B5MDA3
    • B7ZW32
    • E9PC75
    • Q8NCM7
    • Q96E37
    • Q9H6L3
    • Q9H6W0

    Protein attributes for ARHGEF28 Gene

    Size:
    1705 amino acids
    Molecular mass:
    191891 Da
    Quaternary structure:
    • Homooligomer; forms cytoplasmic aggregates. Forms a complex with MAPK8 and MAPK8IP1. Interacts with RHOA. Interacts with microtubules. Interacts with YWHAE and YWHAH. Interacts with PTK2/FAK1. Interacts with NEFL (By similarity). Interacts with CTNND2; prevents interaction with RHOA.
    SequenceCaution:
    • Sequence=AAH12946.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15243.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC02707.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF28 Gene

neXtProt entry for ARHGEF28 Gene

Proteomics data for ARHGEF28 Gene at MOPED

Post-translational modifications for ARHGEF28 Gene

  • Phosphorylated on tyrosine upon stimulation of cells by laminin.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGEF28 Gene

Domains for ARHGEF28 Gene

Protein Domains for ARHGEF28 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N1W1

UniProtKB/Swiss-Prot:

ARG28_HUMAN :
  • Q8N1W1
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with ARHGEF28: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for ARHGEF28 Gene

Function for ARHGEF28 Gene

Molecular function for ARHGEF28 Gene

UniProtKB/Swiss-Prot Function: Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).

Gene Ontology (GO) - Molecular Function for ARHGEF28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IEA --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARHGEF28: view

miRNA for ARHGEF28 Gene

miRTarBase miRNAs that target ARHGEF28

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGEF28 Gene

Localization for ARHGEF28 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF28 Gene

Cytoplasm. Cell membrane. Note=Colocalizes with the microtubule radial and cortical systems. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ARHGEF28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with ARHGEF28: view

No data available for Subcellular locations from COMPARTMENTS for ARHGEF28 Gene

Pathways for ARHGEF28 Gene

genes like me logo Genes that share pathways with ARHGEF28: view

Pathways by source for ARHGEF28 Gene

Gene Ontology (GO) - Biological Process for ARHGEF28 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007411 axon guidance TAS --
GO:0021955 central nervous system neuron axonogenesis IEA --
GO:0035023 regulation of Rho protein signal transduction --
GO:0035556 intracellular signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGEF28: view

Transcripts for ARHGEF28 Gene

Unigene Clusters for ARHGEF28 Gene

Rho guanine nucleotide exchange factor (GEF) 28:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF28 Gene

No ASD Table

Relevant External Links for ARHGEF28 Gene

GeneLoc Exon Structure for
ARHGEF28
ECgene alternative splicing isoforms for
ARHGEF28

Expression for ARHGEF28 Gene

mRNA expression in normal human tissues for ARHGEF28 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF28 Gene

This gene is overexpressed in Adrenal Gland (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGEF28 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF28 Gene Hs.482521

genes like me logo Genes that share expressions with ARHGEF28: view

No data available for mRNA Expression by UniProt/SwissProt for ARHGEF28 Gene

Orthologs for ARHGEF28 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF28 35
  • 99.15 (n)
  • 98.73 (a)
RGNEF 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RGNEF 35
  • 86.59 (n)
  • 83.31 (a)
RGNEF 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF28 35
  • 83.8 (n)
  • 81.49 (a)
ARHGEF28 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef28 35
  • 81.88 (n)
  • 81.15 (a)
Arhgef28 16
Arhgef28 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF28 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF28 36
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef28 35
  • 81.39 (n)
  • 79.45 (a)
chicken
(Gallus gallus)
Aves ARHGEF28 36
  • 58 (a)
OneToOne
LOC427201 35
  • 66.95 (n)
  • 61.75 (a)
lizard
(Anolis carolinensis)
Reptilia ARHGEF28 36
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef28 35
  • 60.75 (n)
  • 56.16 (a)
Str.9159 35
zebrafish
(Danio rerio)
Actinopterygii arhgef28 35
  • 53.12 (n)
  • 46.02 (a)
arhgef28 36
  • 38 (a)
OneToMany
ARHGEF28 (2 of 2) 36
  • 34 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10188 36
  • 21 (a)
OneToMany
Species with no ortholog for ARHGEF28:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF28 Gene

ENSEMBL:
Gene Tree for ARHGEF28 (if available)
TreeFam:
Gene Tree for ARHGEF28 (if available)

Paralogs for ARHGEF28 Gene

Selected SIMAP similar genes for ARHGEF28 Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for ARHGEF28 Gene

genes like me logo Genes that share paralogs with ARHGEF28: view

Variants for ARHGEF28 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF28 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs45341 -- 73,927,598(+) AAGTG(A/G)TCCCC intron-variant
rs45342 -- 73,927,652(+) CAACA(C/T)CTGGC intron-variant
rs150132 -- 73,941,462(+) AAGGG(C/T)TTTTC utr-variant-3-prime
rs153971 -- 73,937,378(-) AAGTG(A/G)GATCT intron-variant
rs157450 -- 73,914,786(-) atcac(A/G)ccact intron-variant

Relevant External Links for ARHGEF28 Gene

HapMap Linkage Disequilibrium report
ARHGEF28
Human Gene Mutation Database (HGMD)
ARHGEF28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARHGEF28 Gene

Disorders for ARHGEF28 Gene

No disorders were found for ARHGEF28 Gene.

No data available for UniProtKB/Swiss-Prot for ARHGEF28 Gene

Publications for ARHGEF28 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Identification of a novel, putative Rho-specific GDP/GTP exchange factor and a RhoA-binding protein: control of neuronal morphology. (PMID: 9199174) Gebbink M.F. … Moolenaar W.H. (J. Cell Biol. 1997) 2 3
  3. Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons. (PMID: 10574993) Meyer D. … Margolis B. (J. Biol. Chem. 1999) 3 4
  4. Characterization of p190RhoGEF, a RhoA-specific guanine nucleotide exchange factor that interacts with microtubules. (PMID: 11058585) van Horck F.P. … Kranenburg O. (J. Biol. Chem. 2001) 2 3
  5. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PMID: 12056414) Ohara O. … Koseki H. (DNA Res. 2002) 3 4

Products for ARHGEF28 Gene

Sources for ARHGEF28 Gene

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