Aliases for ARHGEF28 Gene
External Ids for ARHGEF28 Gene
Previous GeneCards Identifiers for ARHGEF28 Gene
This gene encodes a member of the Rho guanine nucleotide exchange factor family. The encoded protein interacts with low molecular weight neurofilament mRNA and may be involved in the formation of amyotrophic lateral sclerosis neurofilament aggregates. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]
GeneCards Summary for ARHGEF28 Gene
ARHGEF28 (Rho Guanine Nucleotide Exchange Factor (GEF) 28) is a Protein Coding gene. Among its related pathways are Regulation of RhoA activity and Signaling events mediated by focal adhesion kinase. GO annotations related to this gene include RNA binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF11.
UniProtKB/Swiss-Prot for ARHGEF28 Gene
Functions as a RHOA-specific guanine nucleotide exchange factor regulating signaling pathways downstream of integrins and growth factor receptors. Functions in axonal branching, synapse formation and dendritic morphogenesis. Functions also in focal adhesion formation, cell motility and B-lymphocytes activation. May regulate NEFL expression and aggregation and play a role in apoptosis (By similarity).