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ARHGEF26 Gene

protein-coding   GIFtS: 50
GCID: GC03P153839

Rho Guanine Nucleotide Exchange Factor (GEF) 26

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 261 2     CSGEF2
Src Homology 3 Domain-Containing Guanine Nucleotide Exchange Factor1 2     HMFN18642
SGEF2 3     Rho Guanine Nucleotide Exchange Factor 262
SH3 Domain-Containing Guanine Exchange Factor2 3     

External Ids:    HGNC: 244901   Entrez Gene: 260842   Ensembl: ENSG000001147907   UniProtKB: Q96DR73   

Export aliases for ARHGEF26 gene to outside databases

Previous GC identifer: GC03P151230


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGEF26 Gene:
This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate
Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays
a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of
chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed
for this gene. (provided by RefSeq, Oct 2011)

GeneCards Summary for ARHGEF26 Gene:
ARHGEF26 (Rho guanine nucleotide exchange factor (GEF) 26) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.

UniProtKB/Swiss-Prot: ARHGQ_HUMAN, Q96DR7
Function: Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane
ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial
migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton
rearrangements and promotes bacterial entry




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NT_187533.1  NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ARHGEF26
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF26 promoter sequence
   Search Chromatin IP Primers for ARHGEF26

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF26


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.2   Ensembl cytogenetic band:  3q25.2   HGNC cytogenetic band: 3q25.2

ARHGEF26 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF26 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P153839:  view genomic region     (about GC identifiers)

Start:
153,838,792 bp from pter      End:
153,975,616 bp from pter
Size:
136,825 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: ARHGQ_HUMAN, Q96DR7 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 26  
Size: 871 amino acids; 97346 Da
Subunit: Interacts with ICAM1 and RHOG
Sequence caution: Sequence=AAH16628.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=AAL27002.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAB14159.1; Type=Erroneous
initiation; Note=Translation N-terminally extended; Sequence=BAB14292.1; Type=Erroneous initiation;
Note=Translation N-terminally extended;
Secondary accessions: B3KVP8 E9PBD0 Q68CL1 Q6AZ96 Q6Q8Q8 Q96AW8 Q96DR6 Q9H9D7 Q9H9R2 Q9UFW5
Alternative splicing: 3 isoforms:  Q96DR7-1   Q96DR7-3   Q96DR7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGEF26: NX_Q96DR7

Explore proteomics data for ARHGEF26 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGEF26 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001238891.1  NP_001238892.1  NP_056410.3  

    ENSEMBL proteins: 
     ENSP00000348828   ENSP00000423418   ENSP00000424446   ENSP00000423295  

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    antibodies-online antibodies for ARHGEF26 (11 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    4 InterPro protein domains:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q96DR7

    ProtoNet protein and cluster: Q96DR7

    3 Blocks protein domains:
    IPB000219 DH domain
    IPB001452 SH3 domain signature
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARHGQ_HUMAN, Q96DR7
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with ARHGEF26           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHGQ_HUMAN, Q96DR7
    Function: Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane
    ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial
    migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton
    rearrangements and promotes bacterial entry
    Induction: Certain mRNA species appear to be up-regulated by androgens in prostate cancer cells

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ARHGEF26           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARHGEF26:
     Increased gamma-H2AX phosphory 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Arhgef26):
     cardiovascular system 

    Find genes that share phenotypes with ARHGEF26           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arhgef26tm1.1Kbur for ARHGEF26

       genOway: Develop your customized and physiologically relevant rodent model for ARHGEF26

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    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF26 (see all 42):
    hsa-miR-513a-5p hsa-miR-3616-5p hsa-miR-301a hsa-miR-3167 hsa-miR-374a* hsa-miR-374c hsa-miR-3148 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF26 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF26

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARHGQ_HUMAN, Q96DR7: Cell projection, ruffle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001726ruffle IEA--

    Find genes that share ontologies with ARHGEF26           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGEF26 About    
    See pathways by source

    SuperPathContained pathways About
    1Bacterial invasion of epithelial cells
    Bacterial invasion of epithelial cells


    Find genes that share SuperPaths with ARHGEF26           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for ARHGEF26):
        Bacterial invasion of epithelial cells

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGEF26
    Interactions:

        Search GeneGlobe Interaction Network for ARHGEF26

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for ARHGEF26 (ENSP000003488284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOGENSP000003394674STRING: ENSP00000339467
    EPHA6ENSP000003743234STRING: ENSP00000374323
    LMO7ENSP000003421124STRING: ENSP00000342112
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035023regulation of Rho protein signal transduction ----

    Find genes that share ontologies with ARHGEF26           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGEF26 (ARHGQ)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGEF26 gene (3 alternative transcripts): 
    NM_001251962.1  NM_001251963.1  NM_015595.3  

    Unigene Cluster for ARHGEF26:

    Rho guanine nucleotide exchange factor (GEF) 26
    Hs.240845  [show with all ESTs]
    Unigene Representative Sequence: NM_001251962
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000356448(uc021xgc.1 uc011bog.1 uc011boh.1) ENST00000465093
    ENST00000496710 ENST00000465817 ENST00000483068(uc011boi.1)
    miRNA
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    hsa-miR-513a-5p hsa-miR-3616-5p hsa-miR-301a hsa-miR-3167 hsa-miR-374a* hsa-miR-374c hsa-miR-3148 hsa-miR-130b
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF26 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF26
      QuantiFast Probe-based Assays in human, mouse, rat ARHGEF26

    Additional mRNA sequence: 

    AB073386.1 AF415175.1 AF415176.1 AK022655.1 AK022884.1 AK123040.1 AK127282.1 AL117429.1 
    AY552599.1 BC016628.1 BC078655.1 

    8 DOTS entries:

    DT.407924  DT.100748311  DT.95322803  DT.101981041  DT.97800976  DT.120912783  DT.97780247  DT.102824403 

    Selected AceView cDNA sequences (see all 113):

    AA364836 BM793807 BX503267 BM729068 BM987736 CB122093 AU125271 W96189 
    AA425141 AV725197 AI057555 AK022655 AF415175 N98940 AI740900 BE708807 
    AY552599 CF147183 BF221677 BC078655 N66657 AK127282 AA860087 BI597607 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGEF26 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCTTATGA
    ARHGEF26 Expression
    About this image


    ARHGEF26 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Prostate (Endocrine System)
    ARHGEF26 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGEF26 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.240845

    UniProtKB/Swiss-Prot: ARHGQ_HUMAN, Q96DR7
    Tissue specificity: Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA
    species appear to be specifically expressed in prostate and liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF26 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef261 , 5 Rho guanine nucleotide exchange factor (GEF) 261, 5 84.45(n)1
    86.95(a)1
      3 (29.97 cM)5
    6224341  NM_001081295.11  NP_001074764.11 
     623383445 
    chicken
    (Gallus gallus)
    Aves ARHGEF261 Rho guanine nucleotide exchange factor (GEF) 26 76.58(n)
    83.18(a)
      429163  XM_426718.4  XP_426718.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF266
    Rho guanine nucleotide exchange factor (GEF) 26
    73(a)
    1 ↔ 1
    3(16704689-16787484)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia arhgef261 Rho guanine nucleotide exchange factor (GEF) 26 65.41(n)
    69.22(a)
      100495357  XM_002933248.2  XP_002933294.2 
    zebrafish
    (Danio rerio)
    Actinopterygii BX957353.16
    Uncharacterized protein
    33(a)
    many ↔ many
    6(26641178-26653666) ENSDARG00000078081
    fruit fly
    (Drosophila melanogaster)
    Insecta Exn6
    Ephexin
    11(a)
    1 → many
    3L(16963113-16987488)
    worm
    (Caenorhabditis elegans)
    Secernentea ephx-16
    Protein EPHX-1, isoform a
    22(a)
    1 → many
    II(4004889-4016077) WBGene00019487


    ENSEMBL Gene Tree for ARHGEF26 (if available)
    TreeFam Gene Tree for ARHGEF26 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGEF26 gene
    ARHGEF192  ARHGEF152  ARHGEF162  NGEF2  ARHGEF52  
    3 SIMAP similar genes for ARHGEF26 using alignment to 1 protein entry:     ARHGQ_HUMAN:
    ARHGEF16    LOC728377    NGEF

    Find genes that share paralogs with ARHGEF26           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGEF26 (see all 2859)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1113813721,2
    C--151255847(+) GTGTCTAA/-TAATT 3 -- cds11Minor allele frequency- -:0.50CSA 2
    rs105414561,2
    C--151258671(+) TAATA-/AATT  
            
    AATAT
    3 -- int11Minor allele frequency- AATT:0.00CSA 2
    rs114155971,2
    C--151259558(+) TTTTTT/-GGTTG 3 -- int1 trp32Minor allele frequency- -:0.00NA CSA 4
    rs40666241,2
    C--151265167(+) ATAAC-/AAAAG 
            
    TATAA
    3 -- int11Minor allele frequency- AAAAG:0.50NA 2
    rs105222831,2
    C--151266585(+) CTTTT-/AAAACA
            
    TTTCT
    3 -- int10--------
    rs677056191,2
    C--151288954(+) TCTCT-/AT/TA 
            
    GAGAA
    3 -- int10--------
    rs105760981,2
    C--151298969(+) CATAT-/ATAATGAT 3 -- int10--------
    rs1495145921,2
    C--151306424(+) TTGGG-/TGTTTT 3 -- int10--------
    rs601583331,2
    C--151325779(+) GAGAG-/AG    
       
    /AGTG
    TGTGT
    3 -- int10--------
    rs133260331,2
    C--151329064(+) TTTTTA/TTATTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for ARHGEF26 (153838792 - 153975616 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARHGEF26:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1003556CNV Insertion20482838
    nsv508962CNV Insertion20534489
    nsv4072CNV Insertion18451855
    esv1286199CNV Insertion17803354

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGEF26 gene, integrated from 10 sources (see all 18):
    (articles sorted by number of sources associating them with ARHGEF26)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells. (PubMed id 12697679)1, 2, 3, 9 Qi H.... Labrie C. (Endocrinology 2003)
    2. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. (PubMed id 15133129)1, 2, 3 Ellerbroek S.M.... Burridge K. (Mol. Biol. Cell 2004)
    3. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PubMed id 15221005)1, 2 Yamada S....Nakagawara A. (Oncogene 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Differential activation and function of Rho GTPases during Salmonella-host cell interactions. (PubMed id 17074883)2, 9 Patel J.C. and Galan J.E. (J. Cell Biol. 2006)
    6. The Src homology 3 domain-containing guanine nucleotide exchange factor is overexpressed in high-grade gliomas and promotes tumor necrosis factor-like weak inducer of apoptosis-fibroblast growth factor-inducible 14-induced cell migration and invasion via tumor necrosis factor receptor-associated factor 2. (PubMed id 23775076)1 Fortin Ensign S.P....Tran N.L. (J. Biol. Chem. 2013)
    7. SGEF enhances EGFR stability through delayed EGFR trafficking from early to late endosomes. (PubMed id 23661635)1 Wang H....Zhou J. (Carcinogenesis 2013)
    8. The invasive capacity of HPV transformed cells requires the hDlg-dependent enhancement of SGEF/RhoG activity. (PubMed id 22383878)1 Krishna Subbaiah V....Banks L. (PLoS Pathog. 2012)
    9. SGEF is overexpressed in prostate cancer and contributes to prostate cancer progression. (PubMed id 22824926)1 Wang H....Zhou J. (Oncol. Rep. 2012)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26084 HGNC: 24490 AceView: SGEF Ensembl:ENSG00000114790 euGenes: HUgn26084
    ECgene: ARHGEF26 Kegg: 26084 H-InvDB: ARHGEF26

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARHGEF26 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGEF26 gene:
    Search GeneIP for patents involving ARHGEF26

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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