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Aliases for ARHGEF26 Gene

Aliases for ARHGEF26 Gene

  • Rho Guanine Nucleotide Exchange Factor 26 2 3 5
  • Src Homology 3 Domain-Containing Guanine Nucleotide Exchange Factor 2 3
  • Rho Guanine Nucleotide Exchange Factor (GEF) 26 2 3
  • SH3 Domain-Containing Guanine Exchange Factor 3 4
  • SGEF 3 4
  • Testicular Tissue Protein Li 171 3
  • HMFN1864 3
  • CSGEF 3

External Ids for ARHGEF26 Gene

Previous GeneCards Identifiers for ARHGEF26 Gene

  • GC03P153839
  • GC03P151230

Summaries for ARHGEF26 Gene

Entrez Gene Summary for ARHGEF26 Gene

  • This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for ARHGEF26 Gene

ARHGEF26 (Rho Guanine Nucleotide Exchange Factor 26) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF16.

UniProtKB/Swiss-Prot for ARHGEF26 Gene

  • Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF26 Gene

Genomics for ARHGEF26 Gene

Regulatory Elements for ARHGEF26 Gene

Enhancers for ARHGEF26 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F154059 0.9 Ensembl ENCODE 20.2 -60.5 -60543 2.0 ESRRA PKNOX1 HLF DPF2 RAD21 ZNF217 E2F1 GATA3 CTBP1 JUND ARHGEF26-AS1 ARHGEF26 GC03P154024
GH03F154089 0.7 ENCODE 25.6 -31.3 -31254 0.9 ESRRA PKNOX1 ZHX2 DPF2 ZBTB40 RAD21 ZNF217 CTBP1 JUND GATA3 ARHGEF26-AS1 ARHGEF26 GC03P154024
GH03F154132 1.4 FANTOM5 Ensembl ENCODE 11 +12.3 12297 1.0 PKNOX1 INSM2 KLF17 FEZF1 ZNF2 ZNF366 SCRT2 OVOL3 ZEB2 TSHZ1 ARHGEF26-AS1 ARHGEF26 LOC105374167
GH03F154120 0.9 ENCODE 16.2 +1.1 1087 2.6 ARID4B SIN3A YY1 GLIS2 EGR1 ZNF366 EGR2 ZNF263 SP3 SP5 ARHGEF26 ARHGEF26-AS1 LOC105374167
GH03F154223 1 Ensembl ENCODE 10.7 +103.7 103677 1.4 ESRRA NR2F1 MNT DPF2 CEBPG RAD21 ZNF217 GATA3 CTBP1 SMARCA4 ARHGEF26-AS1 ARHGEF26 LOC105374167
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGEF26 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGEF26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001377255 1398 3599 ARID4B SIN3A YY1 GLIS2 EGR1 ZNF366 EGR2 ZNF263 ZNF362 SP3

Genomic Location for ARHGEF26 Gene

Chromosome:
3
Start:
154,121,003 bp from pter
End:
154,257,827 bp from pter
Size:
136,825 bases
Orientation:
Plus strand

Genomic View for ARHGEF26 Gene

Genes around ARHGEF26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF26 Gene

Proteins for ARHGEF26 Gene

  • Protein details for ARHGEF26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DR7-ARHGQ_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 26
    Protein Accession:
    Q96DR7
    Secondary Accessions:
    • B3KVP8
    • E9PBD0
    • Q68CL1
    • Q6AZ96
    • Q6Q8Q8
    • Q96AW8
    • Q96DR6
    • Q9H9D7
    • Q9H9R2
    • Q9UFW5

    Protein attributes for ARHGEF26 Gene

    Size:
    871 amino acids
    Molecular mass:
    97346 Da
    Quaternary structure:
    • Interacts with ICAM1 and RHOG.
    SequenceCaution:
    • Sequence=AAH16628.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL27002.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAB14159.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF26 Gene

Post-translational modifications for ARHGEF26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF26 Gene

No data available for DME Specific Peptides for ARHGEF26 Gene

Domains & Families for ARHGEF26 Gene

Protein Domains for ARHGEF26 Gene

Suggested Antigen Peptide Sequences for ARHGEF26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DR7

UniProtKB/Swiss-Prot:

ARHGQ_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGEF26: view

Function for ARHGEF26 Gene

Molecular function for ARHGEF26 Gene

UniProtKB/Swiss-Prot Function:
Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
UniProtKB/Swiss-Prot Induction:
Certain mRNA species appear to be up-regulated by androgens in prostate cancer cells.

Gene Ontology (GO) - Molecular Function for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IEA --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with ARHGEF26: view
genes like me logo Genes that share phenotypes with ARHGEF26: view

Animal Models for ARHGEF26 Gene

MGI Knock Outs for ARHGEF26:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGEF26 Gene

Localization for ARHGEF26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF26 Gene

Cell projection, ruffle.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF26 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ARHGEF26: view

Pathways & Interactions for ARHGEF26 Gene

genes like me logo Genes that share pathways with ARHGEF26: view

Gene Ontology (GO) - Biological Process for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001886 endothelial cell morphogenesis IEA --
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0097178 ruffle assembly IEA --
genes like me logo Genes that share ontologies with ARHGEF26: view

No data available for SIGNOR curated interactions for ARHGEF26 Gene

Drugs & Compounds for ARHGEF26 Gene

(1) Drugs for ARHGEF26 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGEF26: view

Transcripts for ARHGEF26 Gene

Unigene Clusters for ARHGEF26 Gene

Rho guanine nucleotide exchange factor (GEF) 26:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF26 Gene

No ASD Table

Relevant External Links for ARHGEF26 Gene

GeneLoc Exon Structure for
ARHGEF26
ECgene alternative splicing isoforms for
ARHGEF26

Expression for ARHGEF26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGEF26 Gene

This gene is overexpressed in Plasma (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGEF26 Gene



Protein tissue co-expression partners for ARHGEF26 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF26 Gene:

ARHGEF26

SOURCE GeneReport for Unigene cluster for ARHGEF26 Gene:

Hs.240845

mRNA Expression by UniProt/SwissProt for ARHGEF26 Gene:

Q96DR7-ARHGQ_HUMAN
Tissue specificity: Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.
genes like me logo Genes that share expression patterns with ARHGEF26: view

Primer Products

No data available for mRNA differential expression in normal tissues for ARHGEF26 Gene

Orthologs for ARHGEF26 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF26 34 35
  • 99.45 (n)
cow
(Bos Taurus)
Mammalia ARHGEF26 34 35
  • 89 (n)
dog
(Canis familiaris)
Mammalia ARHGEF26 34 35
  • 87.73 (n)
rat
(Rattus norvegicus)
Mammalia Arhgef26 34
  • 84.51 (n)
mouse
(Mus musculus)
Mammalia Arhgef26 34 16 35
  • 84.45 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF26 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 64 (a)
OneToMany
-- 35
  • 60 (a)
OneToMany
chicken
(Gallus gallus)
Aves ARHGEF26 34 35
  • 76.58 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGEF26 35
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef26 34
  • 65.41 (n)
zebrafish
(Danio rerio)
Actinopterygii BX957353.1 35
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Exn 35
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ephx-1 35
  • 22 (a)
OneToMany
Species where no ortholog for ARHGEF26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF26 Gene

ENSEMBL:
Gene Tree for ARHGEF26 (if available)
TreeFam:
Gene Tree for ARHGEF26 (if available)

Paralogs for ARHGEF26 Gene

Paralogs for ARHGEF26 Gene

(3) SIMAP similar genes for ARHGEF26 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF26: view

Variants for ARHGEF26 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF26 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs10053 -- 154,257,600(-) ACAAC(A/G)CTTTA utr-variant-3-prime
rs1017597 -- 154,156,170(-) TATTT(C/T)TTACT intron-variant
rs10522283 -- 154,157,168(+) CTTTT(-/AAAACA)TTTCT intron-variant
rs10535573 -- 154,250,963(+) GTATT(-/AG)AGAGA intron-variant, nc-transcript-variant
rs10559112 -- 154,120,968(+) TTAAG(-/ACC)ACCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF26 Gene

Variant ID Type Subtype PubMed ID
nsv508962 CNV insertion 20534489
nsv481083 CNV novel sequence insertion 20440878
nsv480100 CNV novel sequence insertion 20440878
nsv4072 CNV insertion 18451855
nsv1139170 CNV deletion 24896259
nsv1131740 CNV deletion 24896259
nsv1117034 CNV deletion 24896259
esv3598250 CNV gain 21293372
esv3598249 CNV loss 21293372
esv3412820 CNV duplication 20981092
esv2763308 CNV loss 21179565
esv1286199 CNV insertion 17803354
esv1003556 CNV insertion 20482838

Variation tolerance for ARHGEF26 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.25; 85.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF26 Gene

Disorders for ARHGEF26 Gene

Relevant External Links for ARHGEF26

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF26

No disorders were found for ARHGEF26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF26 Gene

Publications for ARHGEF26 Gene

  1. Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells. (PMID: 12697679) Qi H. … Labrie C. (Endocrinology 2003) 2 3 4 22 64
  2. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. (PMID: 15133129) Ellerbroek S.M. … Burridge K. (Mol. Biol. Cell 2004) 2 3 4 64
  3. Differential activation and function of Rho GTPases during Salmonella-host cell interactions. (PMID: 17074883) Patel J.C. … Galan J.E. (J. Cell Biol. 2006) 4 22 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4 64

Products for ARHGEF26 Gene

Sources for ARHGEF26 Gene

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