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Aliases for ARHGEF26 Gene

Aliases for ARHGEF26 Gene

  • Rho Guanine Nucleotide Exchange Factor 26 2 3 5
  • Src Homology 3 Domain-Containing Guanine Nucleotide Exchange Factor 2 3
  • Rho Guanine Nucleotide Exchange Factor (GEF) 26 2 3
  • SH3 Domain-Containing Guanine Exchange Factor 3 4
  • SGEF 3 4
  • Testicular Tissue Protein Li 171 3
  • HMFN1864 3
  • CSGEF 3

External Ids for ARHGEF26 Gene

Previous GeneCards Identifiers for ARHGEF26 Gene

  • GC03P153839
  • GC03P151230

Summaries for ARHGEF26 Gene

Entrez Gene Summary for ARHGEF26 Gene

  • This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for ARHGEF26 Gene

ARHGEF26 (Rho Guanine Nucleotide Exchange Factor 26) is a Protein Coding gene. Among its related pathways are Bacterial invasion of epithelial cells. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF15.

UniProtKB/Swiss-Prot for ARHGEF26 Gene

  • Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF26 Gene

Genomics for ARHGEF26 Gene

Regulatory Elements for ARHGEF26 Gene

Promoters for ARHGEF26 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGEF26 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGEF26 Gene

Chromosome:
3
Start:
154,121,003 bp from pter
End:
154,257,827 bp from pter
Size:
136,825 bases
Orientation:
Plus strand

Genomic View for ARHGEF26 Gene

Genes around ARHGEF26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF26 Gene

Proteins for ARHGEF26 Gene

  • Protein details for ARHGEF26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DR7-ARHGQ_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 26
    Protein Accession:
    Q96DR7
    Secondary Accessions:
    • B3KVP8
    • E9PBD0
    • Q68CL1
    • Q6AZ96
    • Q6Q8Q8
    • Q96AW8
    • Q96DR6
    • Q9H9D7
    • Q9H9R2
    • Q9UFW5

    Protein attributes for ARHGEF26 Gene

    Size:
    871 amino acids
    Molecular mass:
    97346 Da
    Quaternary structure:
    • Interacts with ICAM1 and RHOG.
    SequenceCaution:
    • Sequence=AAH16628.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL27002.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAB14159.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF26 Gene

Proteomics data for ARHGEF26 Gene at MOPED

Post-translational modifications for ARHGEF26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF26 Gene

Antibody Products

No data available for DME Specific Peptides for ARHGEF26 Gene

Domains & Families for ARHGEF26 Gene

Protein Domains for ARHGEF26 Gene

Suggested Antigen Peptide Sequences for ARHGEF26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96DR7

UniProtKB/Swiss-Prot:

ARHGQ_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGEF26: view

Function for ARHGEF26 Gene

Molecular function for ARHGEF26 Gene

UniProtKB/Swiss-Prot Function:
Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
UniProtKB/Swiss-Prot Induction:
Certain mRNA species appear to be up-regulated by androgens in prostate cancer cells.
genes like me logo Genes that share phenotypes with ARHGEF26: view

Animal Models for ARHGEF26 Gene

MGI Knock Outs for ARHGEF26:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGEF26 Gene

Localization for ARHGEF26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF26 Gene

Cell projection, ruffle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF26 Gene COMPARTMENTS Subcellular localization image for ARHGEF26 gene
Compartment Confidence
nucleus 4
cytosol 3
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for ARHGEF26 Gene

Pathways & Interactions for ARHGEF26 Gene

genes like me logo Genes that share pathways with ARHGEF26: view

Pathways by source for ARHGEF26 Gene

1 KEGG pathway for ARHGEF26 Gene

Interacting Proteins for ARHGEF26 Gene

Gene Ontology (GO) - Biological Process for ARHGEF26 Gene

None

No data available for SIGNOR curated interactions for ARHGEF26 Gene

Drugs & Compounds for ARHGEF26 Gene

(1) Drugs for ARHGEF26 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGEF26: view

Transcripts for ARHGEF26 Gene

Unigene Clusters for ARHGEF26 Gene

Rho guanine nucleotide exchange factor (GEF) 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF26 Gene

No ASD Table

Relevant External Links for ARHGEF26 Gene

GeneLoc Exon Structure for
ARHGEF26
ECgene alternative splicing isoforms for
ARHGEF26

Expression for ARHGEF26 Gene

mRNA expression in normal human tissues for ARHGEF26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGEF26 Gene

This gene is overexpressed in Plasma (66.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGEF26 Gene



SOURCE GeneReport for Unigene cluster for ARHGEF26 Gene Hs.240845

mRNA Expression by UniProt/SwissProt for ARHGEF26 Gene

Q96DR7-ARHGQ_HUMAN
Tissue specificity: Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.
genes like me logo Genes that share expression patterns with ARHGEF26: view

Protein tissue co-expression partners for ARHGEF26 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARHGEF26 Gene

Orthologs for ARHGEF26 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF26 35
  • 99.45 (n)
  • 99.29 (a)
ARHGEF26 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGEF26 36
  • 90 (a)
OneToOne
ARHGEF26 35
  • 89 (n)
  • 89.97 (a)
dog
(Canis familiaris)
Mammalia ARHGEF26 35
  • 87.73 (n)
  • 93.94 (a)
ARHGEF26 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef26 16
Arhgef26 35
  • 84.45 (n)
  • 86.95 (a)
Arhgef26 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF26 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 60 (a)
OneToMany
-- 36
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arhgef26 35
  • 84.51 (n)
  • 87.63 (a)
chicken
(Gallus gallus)
Aves ARHGEF26 35
  • 76.58 (n)
  • 83.18 (a)
ARHGEF26 36
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF26 36
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef26 35
  • 65.41 (n)
  • 69.22 (a)
zebrafish
(Danio rerio)
Actinopterygii BX957353.1 36
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Exn 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ephx-1 36
  • 22 (a)
OneToMany
Species with no ortholog for ARHGEF26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF26 Gene

ENSEMBL:
Gene Tree for ARHGEF26 (if available)
TreeFam:
Gene Tree for ARHGEF26 (if available)

Paralogs for ARHGEF26 Gene

Paralogs for ARHGEF26 Gene

(3) SIMAP similar genes for ARHGEF26 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF26: view

Variants for ARHGEF26 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF26 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
VAR_039425 -
VAR_039426 -
VAR_058205 -
rs173328 -- 154,256,137(-) TAAGA(A/C)CAATA utr-variant-3-prime
rs436852 -- 154,195,614(+) gcagc(A/G)aggta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF26 Gene

Variant ID Type Subtype PubMed ID
nsv4072 CNV Insertion 18451855
nsv508962 CNV Insertion 20534489
esv1003556 CNV Insertion 20482838
esv1286199 CNV Insertion 17803354

Variation tolerance for ARHGEF26 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.25; 85.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF26 Gene

HapMap Linkage Disequilibrium report
ARHGEF26

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF26 Gene

Disorders for ARHGEF26 Gene

Relevant External Links for ARHGEF26

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF26

No disorders were found for ARHGEF26 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF26 Gene

Publications for ARHGEF26 Gene

  1. Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells. (PMID: 12697679) Qi H. … Labrie C. (Endocrinology 2003) 2 3 4 23 67
  2. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. (PMID: 15133129) Ellerbroek S.M. … Burridge K. (Mol. Biol. Cell 2004) 2 3
  3. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Grb2 interacts with SGEF and antagonizes the ability of SGEF to enhance EGF-induced ERK1/2 activation. (PMID: 24399467) Wang H. … Zhou J. (Mol. Cell. Biochem. 2014) 3

Products for ARHGEF26 Gene

Sources for ARHGEF26 Gene

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