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Aliases for ARHGEF26 Gene

Aliases for ARHGEF26 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 26 2 3
  • Src Homology 3 Domain-Containing Guanine Nucleotide Exchange Factor 2 3
  • SH3 Domain-Containing Guanine Exchange Factor 3 4
  • SGEF 3 4
  • Rho Guanine Nucleotide Exchange Factor 26 3
  • HMFN1864 3
  • CSGEF 3

External Ids for ARHGEF26 Gene

Summaries for ARHGEF26 Gene

Entrez Gene Summary for ARHGEF26 Gene

  • This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for ARHGEF26 Gene

ARHGEF26 (Rho Guanine Nucleotide Exchange Factor (GEF) 26) is a Protein Coding gene. Among its related pathways are Bacterial invasion of epithelial cells. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.

UniProtKB/Swiss-Prot for ARHGEF26 Gene

  • Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF26 Gene

Genomics for ARHGEF26 Gene

Genomic Location for ARHGEF26 Gene

Start:
154,121,003 bp from pter
End:
154,257,827 bp from pter
Size:
136,825 bases
Orientation:
Plus strand

Genomic View for ARHGEF26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF26 Gene

No data available for Regulatory Elements for ARHGEF26 Gene

Proteins for ARHGEF26 Gene

  • Protein details for ARHGEF26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96DR7-ARHGQ_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 26
    Protein Accession:
    Q96DR7
    Secondary Accessions:
    • B3KVP8
    • E9PBD0
    • Q68CL1
    • Q6AZ96
    • Q6Q8Q8
    • Q96AW8
    • Q96DR6
    • Q9H9D7
    • Q9H9R2
    • Q9UFW5

    Protein attributes for ARHGEF26 Gene

    Size:
    871 amino acids
    Molecular mass:
    97346 Da
    Quaternary structure:
    • Interacts with ICAM1 and RHOG.
    SequenceCaution:
    • Sequence=AAH16628.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAL27002.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305}; Sequence=BAB14159.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14292.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF26 Gene

Proteomics data for ARHGEF26 Gene at MOPED

Post-translational modifications for ARHGEF26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF26 Gene

No data available for DME Specific Peptides for ARHGEF26 Gene

Domains for ARHGEF26 Gene

Gene Families for ARHGEF26 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • ARHGEF :Rho guanine nucleotide exchange factors

Protein Domains for ARHGEF26 Gene

UniProtKB/Swiss-Prot:

ARHGQ_HUMAN
Domain:
  • Contains 1 DH (DBL-homology) domain.:
    • Q96DR7
  • Contains 1 PH domain.:
    • Q96DR7
  • Contains 1 SH3 domain.:
    • Q96DR7
genes like me logo Genes that share domains with ARHGEF26: view

Function for ARHGEF26 Gene

Molecular function for ARHGEF26 Gene

UniProtKB/Swiss-Prot Function: Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry.
UniProtKB/Swiss-Prot Induction: Certain mRNA species appear to be up-regulated by androgens in prostate cancer cells.

Gene Ontology (GO) - Molecular Function for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ARHGEF26: view

Phenotypes for ARHGEF26 Gene

MGI mutant phenotypes for ARHGEF26:
inferred from 1 alleles
GenomeRNAi human phenotypes for ARHGEF26:
genes like me logo Genes that share phenotypes with ARHGEF26: view

Animal Models for ARHGEF26 Gene

MGI Knock Outs for ARHGEF26:

miRNA for ARHGEF26 Gene

miRTarBase miRNAs that target ARHGEF26

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for ARHGEF26 Gene

Localization for ARHGEF26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF26 Gene

Cell projection, ruffle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF26 Gene COMPARTMENTS Subcellular localization image for ARHGEF26 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0042995 cell projection --
genes like me logo Genes that share ontologies with ARHGEF26: view

Pathways for ARHGEF26 Gene

genes like me logo Genes that share pathways with ARHGEF26: view

Pathways by source for ARHGEF26 Gene

1 KEGG pathway for ARHGEF26 Gene

Interacting Proteins for ARHGEF26 Gene

Gene Ontology (GO) - Biological Process for ARHGEF26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001886 endothelial cell morphogenesis IEA --
GO:0035023 regulation of Rho protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0097178 ruffle assembly IEA --
genes like me logo Genes that share ontologies with ARHGEF26: view

Transcripts for ARHGEF26 Gene

Unigene Clusters for ARHGEF26 Gene

Rho guanine nucleotide exchange factor (GEF) 26:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF26 Gene

No ASD Table

Relevant External Links for ARHGEF26 Gene

GeneLoc Exon Structure for
ARHGEF26
ECgene alternative splicing isoforms for
ARHGEF26

Expression for ARHGEF26 Gene

mRNA expression in normal human tissues for ARHGEF26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGEF26 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF26 Gene Hs.240845

mRNA Expression by UniProt/SwissProt for ARHGEF26 Gene

Q96DR7-ARHGQ_HUMAN
Tissue specificity: Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver.
genes like me logo Genes that share expressions with ARHGEF26: view

Orthologs for ARHGEF26 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF26 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF26 36
  • 99.45 (n)
  • 99.29 (a)
ARHGEF26 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGEF26 36
  • 89 (n)
  • 89.97 (a)
ARHGEF26 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF26 36
  • 87.73 (n)
  • 93.94 (a)
ARHGEF26 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef26 36
  • 84.45 (n)
  • 86.95 (a)
Arhgef26 16
Arhgef26 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF26 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 60 (a)
OneToMany
-- 37
  • 64 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arhgef26 36
  • 84.51 (n)
  • 87.63 (a)
chicken
(Gallus gallus)
Aves ARHGEF26 36
  • 76.58 (n)
  • 83.18 (a)
ARHGEF26 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF26 37
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef26 36
  • 65.41 (n)
  • 69.22 (a)
zebrafish
(Danio rerio)
Actinopterygii BX957353.1 37
  • 33 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta Exn 37
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ephx-1 37
  • 22 (a)
OneToMany
Species with no ortholog for ARHGEF26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF26 Gene

ENSEMBL:
Gene Tree for ARHGEF26 (if available)
TreeFam:
Gene Tree for ARHGEF26 (if available)

Paralogs for ARHGEF26 Gene

Paralogs for ARHGEF26 Gene

Selected SIMAP similar genes for ARHGEF26 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF26: view

Variants for ARHGEF26 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF26 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs10053 -- 154,257,600(-) ACAAC(A/G)CTTTA utr-variant-3-prime
rs95506 -- 154,228,628(-) GTCAT(A/C)AACAA intron-variant
rs173328 -- 154,256,137(-) TAAGA(A/C)CAATA utr-variant-3-prime
rs181443 -- 154,241,239(+) TTTTT(G/T)TTTAG intron-variant
rs181547 -- 154,231,913(-) TAGTG(A/C)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF26 Gene

Variant ID Type Subtype PubMed ID
nsv4072 CNV Insertion 18451855
nsv508962 CNV Insertion 20534489
esv1003556 CNV Insertion 20482838
esv1286199 CNV Insertion 17803354

Relevant External Links for ARHGEF26 Gene

HapMap Linkage Disequilibrium report
ARHGEF26

Disorders for ARHGEF26 Gene

No disorders were found for ARHGEF26 Gene.

No data available for UniProtKB/Swiss-Prot for ARHGEF26 Gene

Publications for ARHGEF26 Gene

  1. Isolation of the novel human guanine nucleotide exchange factor Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) and of C-terminal SGEF, an N-terminally truncated form of SGEF, the expression of which is regulated by androgen in prostate cancer cells. (PMID: 12697679) Qi H. … Labrie C. (Endocrinology 2003) 2 3 4 23
  2. SGEF, a RhoG guanine nucleotide exchange factor that stimulates macropinocytosis. (PMID: 15133129) Ellerbroek S.M. … Burridge K. (Mol. Biol. Cell 2004) 2 3 4
  3. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. (PMID: 15221005) Yamada S. … Nakagawara A. (Oncogene 2004) 3 4
  4. Differential activation and function of Rho GTPases during Salmonella-host cell interactions. (PMID: 17074883) Patel J.C. … Galan J.E. (J. Cell Biol. 2006) 4 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for ARHGEF26 Gene

Sources for ARHGEF26 Gene

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