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Aliases for ARHGEF25 Gene

Aliases for ARHGEF25 Gene

  • Rho Guanine Nucleotide Exchange Factor 25 2 3 5
  • RhoA/Rac/Cdc42 Guanine Nucleotide Exchange Factor GEFT 3 4
  • Rho Guanine Nucleotide Exchange Factor (GEF) 25 2 3
  • Guanine Nucleotide Exchange Factor GEFT 3 4
  • Rac/Cdc42/Rho Exchange Factor GEFT 3 4
  • RAC/CDC42 Exchange Factor 2 3
  • P63RhoGEF 3 4
  • GEFT 3 4
  • RhoA/RAC/CDC42 Exchange Factor 3

External Ids for ARHGEF25 Gene

Previous GeneCards Identifiers for ARHGEF25 Gene

  • GC12P055041
  • GC12P058004

Summaries for ARHGEF25 Gene

Entrez Gene Summary for ARHGEF25 Gene

  • Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ARHGEF25 Gene

ARHGEF25 (Rho Guanine Nucleotide Exchange Factor 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Regulation of RhoA activity. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is TRIO.

UniProtKB/Swiss-Prot for ARHGEF25 Gene

  • May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).

Gene Wiki entry for ARHGEF25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF25 Gene

Genomics for ARHGEF25 Gene

Regulatory Elements for ARHGEF25 Gene

Enhancers for ARHGEF25 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F057590 0.2 ENCODE 15.8 -18.8 -18759 1.9 ARID4B SIN3A ZNF2 YY1 ZNF207 SP3 NFYC MXD4 REST KAT8 ENSG00000224713 TSFM ARHGEF25 LOC283387 NEMP1 TSPAN31 ARHGAP9 CYP27B1 PIP4K2C DTX3
GH12F057457 1.2 FANTOM5 ENCODE 14 -149.7 -149690 5.9 HDGF PKNOX1 ARNT CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ARHGAP9 ENSG00000224713 ARHGEF25 NEMP1 GLI1 MARS MIR6758
GH12F057583 0.2 ENCODE 12.3 -26.7 -26688 0.2 HDGF CBX3 TBL1XR1 WRNIP1 ARID4B THRB ZNF2 RAD21 GLIS2 ZNF143 DTX3 ARHGEF25 ENSG00000224713 SLC26A10 GC12P057584 GC12M057556
GH12F057575 0.4 ENCODE 12 -33.5 -33520 1.4 TBP ARID4B ZNF48 RARA SLC30A9 GATA4 CREM THAP11 SP5 MXD4 DTX3 ARHGEF25 SLC26A10 ENSG00000224713 KIF5A DCTN2 B4GALNT1 DDIT3 MBD6 MIR616
GH12F057579 0.4 ENCODE 12 -30.3 -30301 0.8 SOX13 ELF3 DRAP1 TBP MXI1 ATF1 SAP130 ARID4B ZNF384 CEBPG DCTN2 DTX3 ARHGEF25 ENSG00000224713 SLC26A10 KIF5A B4GALNT1 TSPAN31 AGAP2 MBD6
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARHGEF25 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGEF25 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000431430 920 2601 ZNF76 KLF17 ARID4B DMAP1 ZNF48 ZNF366 THAP11 SP3 SP5 OVOL3

Genomic Location for ARHGEF25 Gene

Chromosome:
12
Start:
57,610,180 bp from pter
End:
57,619,379 bp from pter
Size:
9,200 bases
Orientation:
Plus strand

Genomic View for ARHGEF25 Gene

Genes around ARHGEF25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF25 Gene

Proteins for ARHGEF25 Gene

  • Protein details for ARHGEF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VW2-ARHGP_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 25
    Protein Accession:
    Q86VW2
    Secondary Accessions:
    • A6NJH5
    • A9CQZ6
    • F8W7Z4
    • Q8WV84
    • Q96E63

    Protein attributes for ARHGEF25 Gene

    Size:
    580 amino acids
    Molecular mass:
    63843 Da
    Quaternary structure:
    • Interacts (via the DH domain) with BVES (via the C-terminus cytoplasmic tail) (By similarity). Interacts with activated GNAQ and GNA11. Interacts with RHOA, CDC42 and RAC1.

    Three dimensional structures from OCA and Proteopedia for ARHGEF25 Gene

    Alternative splice isoforms for ARHGEF25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF25 Gene

Post-translational modifications for ARHGEF25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF25 Gene

No data available for DME Specific Peptides for ARHGEF25 Gene

Domains & Families for ARHGEF25 Gene

Gene Families for ARHGEF25 Gene

Protein Domains for ARHGEF25 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VW2

UniProtKB/Swiss-Prot:

ARHGP_HUMAN :
  • The guanine nucleotide exchange activity is autoinhibited by the PH domain.
Domain:
  • The guanine nucleotide exchange activity is autoinhibited by the PH domain.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
genes like me logo Genes that share domains with ARHGEF25: view

Function for ARHGEF25 Gene

Molecular function for ARHGEF25 Gene

UniProtKB/Swiss-Prot Function:
May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for ARHGEF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with ARHGEF25: view
genes like me logo Genes that share phenotypes with ARHGEF25: view

Animal Model Products

miRNA for ARHGEF25 Gene

miRTarBase miRNAs that target ARHGEF25

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF25 Gene

Localization for ARHGEF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF25 Gene

Cell membrane. Cytoplasm, myofibril, sarcomere. Note=Highly colocalizes with actin regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF25 Gene COMPARTMENTS Subcellular localization image for ARHGEF25 gene
Compartment Confidence
plasma membrane 5
cytosol 4
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ARHGEF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0030016 myofibril ISS --
genes like me logo Genes that share ontologies with ARHGEF25: view

Pathways & Interactions for ARHGEF25 Gene

genes like me logo Genes that share pathways with ARHGEF25: view

SIGNOR curated interactions for ARHGEF25 Gene

Activates:

Gene Ontology (GO) - Biological Process for ARHGEF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGEF25: view

Drugs & Compounds for ARHGEF25 Gene

(3) Drugs for ARHGEF25 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGEF25: view

Transcripts for ARHGEF25 Gene

Unigene Clusters for ARHGEF25 Gene

Rho guanine nucleotide exchange factor (GEF) 25:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF25 Gene

No ASD Table

Relevant External Links for ARHGEF25 Gene

GeneLoc Exon Structure for
ARHGEF25
ECgene alternative splicing isoforms for
ARHGEF25

Expression for ARHGEF25 Gene

mRNA expression in normal human tissues for ARHGEF25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARHGEF25 Gene

This gene is overexpressed in Colon (20.8), Urinary Bladder (19.2), Cervix (7.6), and Ovary (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGEF25 Gene



Protein tissue co-expression partners for ARHGEF25 Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF25 Gene:

ARHGEF25

SOURCE GeneReport for Unigene cluster for ARHGEF25 Gene:

Hs.61581

mRNA Expression by UniProt/SwissProt for ARHGEF25 Gene:

Q86VW2-ARHGP_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver.
genes like me logo Genes that share expression patterns with ARHGEF25: view

Primer Products

No data available for mRNA differential expression in normal tissues for ARHGEF25 Gene

Orthologs for ARHGEF25 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF25 34 35
  • 99.78 (n)
cow
(Bos Taurus)
Mammalia GEFT 35
  • 92 (a)
OneToOne
ARHGEF25 34
  • 90.79 (n)
dog
(Canis familiaris)
Mammalia ARHGEF25 34 35
  • 89.82 (n)
mouse
(Mus musculus)
Mammalia Arhgef25 34 16 35
  • 86.19 (n)
rat
(Rattus norvegicus)
Mammalia Arhgef25 34
  • 86.18 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF25 35
  • 62 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 3 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 59 (a)
ManyToMany
-- 35
  • 8 (a)
ManyToMany
-- 35
  • 4 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ARHGEF25 (2 of 2) 35
  • 42 (a)
OneToMany
arhgef25b 35
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta trio 35
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 19 (a)
OneToMany
Species where no ortholog for ARHGEF25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF25 Gene

ENSEMBL:
Gene Tree for ARHGEF25 (if available)
TreeFam:
Gene Tree for ARHGEF25 (if available)

Paralogs for ARHGEF25 Gene

Paralogs for ARHGEF25 Gene

(3) SIMAP similar genes for ARHGEF25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF25: view

Variants for ARHGEF25 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF25 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs193921117 Uncertain significance 57,614,324(+) CAACC(A/C)CTCCA intron-variant
rs1038914 -- 57,617,283(+) CTGTA(A/G)TGGGG downstream-variant-500B
rs10437953 -- 57,609,872(+) AAGGG(G/T)AGAGG intron-variant, downstream-variant-500B, upstream-variant-2KB
rs10437954 -- 57,610,139(+) TCCCC(A/G)GACGC intron-variant, downstream-variant-500B, upstream-variant-2KB
rs111272797 -- 57,613,905(+) GCGGC(C/T)CCCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF25 Gene

Variant ID Type Subtype PubMed ID
nsv482992 CNV gain+loss 15286789
nsv559034 CNV loss 21841781

Variation tolerance for ARHGEF25 Gene

Residual Variation Intolerance Score: 44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF25 Gene

Disorders for ARHGEF25 Gene

Relevant External Links for ARHGEF25

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF25

No disorders were found for ARHGEF25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF25 Gene

Publications for ARHGEF25 Gene

  1. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. (PMID: 12547822) Guo X. … Liu M. (J. Biol. Chem. 2003) 2 3 4 22 64
  2. p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. (PMID: 15069594) Lutz S. … Wieland T. (Naunyn Schmiedebergs Arch. Pharmacol. 2004) 3 4 22 64
  3. Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. (PMID: 18096806) Lutz S. … Tesmer J.J. (Science 2007) 3 4 64
  4. The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. (PMID: 15632174) Lutz S. … Wieland T. (J. Biol. Chem. 2005) 3 4 64
  5. Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. (PMID: 16314529) Bryan B.A. … Liu M. (Mol. Cell. Biol. 2005) 3 4 64

Products for ARHGEF25 Gene

Sources for ARHGEF25 Gene

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