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ARHGEF25 Gene

protein-coding   GIFtS: 50
GCID: GC12P058004

Rho Guanine Nucleotide Exchange Factor (GEF) 25

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 251 2     GEFT2 3
RAC/CDC42 Exchange Factor1 2     p63RhoGEF2 3
Guanine Nucleotide Exchange Factor GEFT2 3     Rho Guanine Nucleotide Exchange Factor 252
Rac/Cdc42/Rho Exchange Factor GEFT2 3     RhoA/RAC/CDC42 Exchange Factor2
RhoA/Rac/Cdc42 Guanine Nucleotide Exchange Factor GEFT2 3     

External Ids:    HGNC: 302751   Entrez Gene: 1155572   Ensembl: ENSG000002407717   OMIM: 6102155   UniProtKB: Q86VW23   

Export aliases for ARHGEF25 gene to outside databases

Previous GC identifer: GC12P055041


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGEF25 Gene:
Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate
GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases
involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell
differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jan 2012)

GeneCards Summary for ARHGEF25 Gene:
ARHGEF25 (Rho guanine nucleotide exchange factor (GEF) 25) is a protein-coding gene. Diseases associated with ARHGEF25 include gout, and retinitis. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is KALRN.

UniProtKB/Swiss-Prot: ARHGP_HUMAN, Q86VW2
Function: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces
formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small
GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of
processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1.
Involved in skeletal myogenesis (By similarity)

Gene Wiki entry for ARHGEF25 (GEFT) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Search for regulatory transcription factor binding sites for ARHGEF25
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF25 promoter sequence
   Search Chromatin IP Primers for ARHGEF25

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

ARHGEF25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF25 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P058004:  view genomic region     (about GC identifiers)

Start:
58,003,963 bp from pter      End:
58,013,162 bp from pter
Size:
9,200 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: ARHGP_HUMAN, Q86VW2 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 25  
Size: 580 amino acids; 63843 Da
Subunit: Interacts (via the DH domain) with BVES (via the C-terminus cytoplasmic tail) (By similarity). Interacts
with activated GNAQ and GNA11. Interacts with RHOA, CDC42 and RAC1
1 PDB 3D structure from and Proteopedia for ARHGEF25:
2RGN (3D)    
Secondary accessions: A6NJH5 A9CQZ6 F8W7Z4 Q8WV84 Q96E63
Alternative splicing: 3 isoforms:  Q86VW2-1   Q86VW2-2   Q86VW2-3   

Explore the universe of human proteins at neXtProt for ARHGEF25: NX_Q86VW2

Explore proteomics data for ARHGEF25 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGEF25 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001104740.1  NP_891992.2  

    ENSEMBL proteins: 
     ENSP00000335560   ENSP00000286494  
    Reactome Protein details: Q86VW2

    ARHGEF25 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGEF: Rho guanine nucleotide exchange factors

    3 InterPro protein domains:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q86VW2

    ProtoNet protein and cluster: Q86VW2

    2 Blocks protein domains:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARHGP_HUMAN, Q86VW2
    Domain: The guanine nucleotide exchange activity is autoinhibited by the PH domain
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain


    ARHGEF25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHGP_HUMAN, Q86VW2
    Function: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces
    formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small
    GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of
    processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1.
    Involved in skeletal myogenesis (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
         
    ARHGEF25 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGEF25:
     Synthetic lethal with c-Myc af  Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgef25):
     cardiovascular system  mortality/aging  normal 

    ARHGEF25 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF25
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    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate ARHGEF25:
    hsa-miR-3126-3p hsa-miR-4290 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF25 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARHGP_HUMAN, Q86VW2: Cell membrane (By similarity). Cytoplasm, myofibril, sarcomere. Note=Highly colocalizes with
    actin regions
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    plasma membrane4
    endoplasmic reticulum1
    extracellular1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ISS--
    GO:0030016myofibril ISS--
    GO:0030017sarcomere IEA--

    ARHGEF25 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGEF25 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Regulation of RhoA activity
    Regulation of RhoA activity
    4Regulation of RAC1 activity
    Regulation of RAC1 activity
    5Regulation of CDC42 activity
    Regulation of CDC42 activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ARHGEF25
        Regulation of CDC42 activity
    Regulation of RhoA activity
    Regulation of RAC1 activity

    1 Reactome Pathway for ARHGEF25
        G alpha (q) signalling events



    ARHGEF25 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGEF25
    Interactions:

        Search GeneGlobe Interaction Network for ARHGEF25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGEF25 (Q86VW23 ENSP000003355604) via UniProtKB, MINT, STRING, and/or I2D (see all 143)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    CDC42P609533, ENSP000003144584I2D: score=2 STRING: ENSP00000314458
    RAC1P630003, ENSP000003484614I2D: score=2 STRING: ENSP00000348461
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035023regulation of Rho protein signal transduction ----

    ARHGEF25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARHGEF25 (ARHGP)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for ARHGEF25 gene (3 alternative transcripts): 
    NM_133483.2  NM_001111270.2  NM_182947.3  

    Unigene Cluster for ARHGEF25:

    Rho guanine nucleotide exchange factor (GEF) 25
    Hs.61581  [show with all ESTs]
    Unigene Representative Sequence: NR_046223
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333972(uc009zpy.3 uc001soz.1) ENST00000286494(uc001spb.3 uc001spa.3)
    ENST00000471370 ENST00000469072 ENST00000466399 ENST00000484357 ENST00000477314

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    SwitchGear 3'UTR luciferase reporter plasmidARHGEF25 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB370196.1 AF487514.2 BC012860.1 BC018536.1 BC047559.1 NR_046223.1 

    6 DOTS entries:

    DT.454962  DT.100748921  DT.121109105  DT.95160261  DT.100733656  DT.121109103 

    Selected AceView cDNA sequences (see all 122):

    AW264299 BM783095 CD722079 BM783082 BM740405 AI018809 AI677902 AF331523 
    AI654427 BX451871 BM510136 AK057416 BM783529 BX097050 AW161485 AA031486 
    AA463846 BM750262 AW136644 AI089627 BM748075 BX452641 AL536956 BX112080 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGEF25 expression in normal human tissues (normalized intensities)      ARHGEF25 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCCCCCAA
    ARHGEF25 Expression
    About this image


    ARHGEF25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium
     
     Eye (Sensory Organs)
             Retina
    ARHGEF25 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGEF25 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.61581

    UniProtKB/Swiss-Prot: ARHGP_HUMAN, Q86VW2
    Tissue specificity: Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and
    muscle. Also detected in kidney and liver

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF25 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef251 , 5 Rho guanine nucleotide exchange factor (GEF) 251, 5 86.19(n)1
    87.38(a)1
      10 (74.50 cM)5
    526661  NM_028027.31  NP_082303.21 
     1271825215 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 3)
    Uncharacterized protein
    (see all 3)
    8(a)
    59(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    GL343253.1(1599940-1641511)
    AAWZ02040341(171-6327)
    zebrafish
    (Danio rerio)
    Actinopterygii ARHGEF25 (2 of 2)6
    arhgef25b6
    Rho guanine nucleotide exchange factor (GEF) 25b
    42(a)
    41(a)
    1 ↔ many
    1 ↔ many
    23(28152716-28262790) ENSDARG00000030766
    6(39187034-39206779) ENSDARG00000014465
    fruit fly
    (Drosophila melanogaster)
    Insecta trio6
    trio
    7(a)
    1 → many
    3L(995982-1034875)


    ENSEMBL Gene Tree for ARHGEF25 (if available)
    TreeFam Gene Tree for ARHGEF25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGEF25 gene
    KALRN2  MCF2L22  PLEKHG4B2  TRIO2  MCF2L2  KIAA17552  PLEKHG42  ARHGEF402  
    MCF22  
    3 SIMAP similar genes for ARHGEF25 using alignment to 1 protein entry:     ARHGP_HUMAN:
    tgat    KALRN    TRIO

    ARHGEF25 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGEF25 (see all 283)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1382503721,2
    --57836321(+) CTTCAC/TATTTT 1 -- us2k10--------
    rs1843591941,2
    --57836439(+) AACACA/GTAAGG 1 -- us2k10--------
    rs3766571471,2
    C--57836745(+) AAGGCA/GTTTGA 1 -- us2k10--------
    rs2013654341,2
    C--57836770(+) TCACTA/GTCGGC 1 -- us2k10--------
    rs1120343031,2
    C,F--57836911(+) CATTTC/TCACTG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs23063901,2
    C,F,A,H--57836937(+) CCTCGC/TTCACG 1 -- us2k124Minor allele frequency- T:0.42EA NS NA WA 4070
    rs1429722191,2
    --57837015(+) TGGTCC/TTGGTG 1 -- us2k10--------
    rs1450392811,2
    --57837040(+) TACAAA/CAATAA 1 -- us2k10--------
    rs1388904881,2
    C--57837470(+) GAGCCA/GCTCCC 1 -- us2k10--------
    rs1174053001,2
    C,F--57837608(+) AAGGAC/TCTAGG 3 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for ARHGEF25 (58003963 - 58013162 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARHGEF25: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGEF25
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGEF25

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610215    OMIM disorders: --

    3 diseases for ARHGEF25:    About MalaCards
    gout    retinitis    neuronitis


    ARHGEF25 for disorders           About GeneDecksing


    Export disorders for ARHGEF25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGEF25 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ARHGEF25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. (PubMed id 12547822)1, 2, 3, 9 Guo X.... Liu M. (J. Biol. Chem. 2003)
    2. p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. (PubMed id 15069594)1, 2, 9 Lutz S....Wieland T. (Naunyn Schmiedebergs Arch. Pharmacol. 2004)
    3. Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. (PubMed id 18096806)1, 2 Lutz S....Tesmer J.J. (Science 2007)
    4. The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. (PubMed id 15632174)1, 2 Lutz S.... Wieland T. (J. Biol. Chem. 2005)
    5. Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. (PubMed id 16314529)1, 2 Bryan B.A....Liu M. (Mol. Cell. Biol. 2005)
    6. Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere. (PubMed id 11861769)1, 2 Souchet M.... Calmels T.P. (J. Cell Sci. 2002)
    7. Signaling efficiency of GI+q through its effectors p63RhoGEF and GEFT depends on their subcellular location. (PubMed id 23884432)1 Goedhart J....Gadella T.W. (Sci Rep 2013)
    8. p63RhoGEF-mediated formation of a single polarized lamellipodium is required for chemotactic migration in breast carcinoma cells. (PubMed id 23380069)1 Hayashi A....Mizuno K. (FEBS Lett. 2013)
    9. p63RhoGEF couples GI+(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility. (PubMed id 21885830)1 Momotani K....Somlyo A.V. (Circ. Res. 2011)
    10. Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells. (PubMed id 21832057)1 Aittaleb M....Tesmer J.J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 115557 HGNC: 30275 AceView: GEFTandSLC26A10 Ensembl:ENSG00000240771 euGenes: HUgn115557
    ECgene: ARHGEF25 H-InvDB: ARHGEF25

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGEF25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGEF25 gene:
    Search GeneIP for patents involving ARHGEF25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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