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Aliases for ARHGEF25 Gene

Aliases for ARHGEF25 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 25 2 3
  • RhoA/Rac/Cdc42 Guanine Nucleotide Exchange Factor GEFT 3 4
  • Guanine Nucleotide Exchange Factor GEFT 3 4
  • Rac/Cdc42/Rho Exchange Factor GEFT 3 4
  • RAC/CDC42 Exchange Factor 2 3
  • P63RhoGEF 3 4
  • GEFT 3 4
  • Rho Guanine Nucleotide Exchange Factor 25 3
  • RhoA/RAC/CDC42 Exchange Factor 3

External Ids for ARHGEF25 Gene

Summaries for ARHGEF25 Gene

Entrez Gene Summary for ARHGEF25 Gene

  • Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell differentiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for ARHGEF25 Gene

ARHGEF25 (Rho Guanine Nucleotide Exchange Factor (GEF) 25) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF40.

UniProtKB/Swiss-Prot for ARHGEF25 Gene

  • May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).

Gene Wiki entry for ARHGEF25 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF25 Gene

Genomics for ARHGEF25 Gene

Genomic Location for ARHGEF25 Gene

Start:
57,610,180 bp from pter
End:
57,619,379 bp from pter
Size:
9,200 bases
Orientation:
Plus strand

Genomic View for ARHGEF25 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF25 Gene

No data available for Regulatory Elements for ARHGEF25 Gene

Proteins for ARHGEF25 Gene

  • Protein details for ARHGEF25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VW2-ARHGP_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 25
    Protein Accession:
    Q86VW2
    Secondary Accessions:
    • A6NJH5
    • A9CQZ6
    • F8W7Z4
    • Q8WV84
    • Q96E63

    Protein attributes for ARHGEF25 Gene

    Size:
    580 amino acids
    Molecular mass:
    63843 Da
    Quaternary structure:
    • Interacts (via the DH domain) with BVES (via the C-terminus cytoplasmic tail) (By similarity). Interacts with activated GNAQ and GNA11. Interacts with RHOA, CDC42 and RAC1.

    Three dimensional structures from OCA and Proteopedia for ARHGEF25 Gene

    Alternative splice isoforms for ARHGEF25 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF25 Gene

Proteomics data for ARHGEF25 Gene at MOPED

Post-translational modifications for ARHGEF25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF25 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF25 Gene

Domains for ARHGEF25 Gene

Gene Families for ARHGEF25 Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors

Protein Domains for ARHGEF25 Gene

Suggested Antigen Peptide Sequences for ARHGEF25 Gene

Graphical View of Domain Structure for InterPro Entry

Q86VW2

UniProtKB/Swiss-Prot:

ARHGP_HUMAN
Domain:
  • The guanine nucleotide exchange activity is autoinhibited by the PH domain.:
    • Q86VW2
  • Contains 1 DH (DBL-homology) domain.:
    • Q86VW2
  • Contains 1 PH domain.:
    • Q86VW2
genes like me logo Genes that share domains with ARHGEF25: view

Function for ARHGEF25 Gene

Molecular function for ARHGEF25 Gene

UniProtKB/Swiss-Prot Function: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1. Involved in skeletal myogenesis (By similarity).

Gene Ontology (GO) - Molecular Function for ARHGEF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with ARHGEF25: view
genes like me logo Genes that share phenotypes with ARHGEF25: view

miRNA for ARHGEF25 Gene

miRTarBase miRNAs that target ARHGEF25

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGEF25 Gene

Localization for ARHGEF25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF25 Gene

Cell membrane. Cytoplasm, myofibril, sarcomere. Note=Highly colocalizes with actin regions.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF25 Gene COMPARTMENTS Subcellular localization image for ARHGEF25 gene
Compartment Confidence
cytosol 4
plasma membrane 4
endoplasmic reticulum 1
extracellular 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARHGEF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane ISS --
GO:0030016 myofibril ISS --
GO:0030017 sarcomere IEA --
genes like me logo Genes that share ontologies with ARHGEF25: view

Pathways for ARHGEF25 Gene

genes like me logo Genes that share pathways with ARHGEF25: view

Gene Ontology (GO) - Biological Process for ARHGEF25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGEF25: view

Transcripts for ARHGEF25 Gene

Unigene Clusters for ARHGEF25 Gene

Rho guanine nucleotide exchange factor (GEF) 25:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF25 Gene

No ASD Table

Relevant External Links for ARHGEF25 Gene

GeneLoc Exon Structure for
ARHGEF25
ECgene alternative splicing isoforms for
ARHGEF25

Expression for ARHGEF25 Gene

mRNA expression in normal human tissues for ARHGEF25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for ARHGEF25 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF25 Gene Hs.61581

mRNA Expression by UniProt/SwissProt for ARHGEF25 Gene

Q86VW2-ARHGP_HUMAN
Tissue specificity: Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and muscle. Also detected in kidney and liver.
genes like me logo Genes that share expressions with ARHGEF25: view

No data available for mRNA differential expression in normal tissues for ARHGEF25 Gene

Orthologs for ARHGEF25 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF25 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF25 35
  • 99.78 (n)
  • 100 (a)
ARHGEF25 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGEF25 35
  • 90.79 (n)
  • 92.57 (a)
GEFT 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF25 35
  • 89.82 (n)
  • 90.79 (a)
ARHGEF25 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef25 35
  • 86.19 (n)
  • 87.38 (a)
Arhgef25 16
Arhgef25 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 3 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF25 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef25 35
  • 86.18 (n)
  • 86.87 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 59 (a)
ManyToMany
-- 36
  • 8 (a)
ManyToMany
-- 36
  • 4 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ARHGEF25 (2 of 2) 36
  • 42 (a)
OneToMany
arhgef25b 36
  • 41 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta trio 36
  • 7 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for ARHGEF25:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF25 Gene

ENSEMBL:
Gene Tree for ARHGEF25 (if available)
TreeFam:
Gene Tree for ARHGEF25 (if available)

Paralogs for ARHGEF25 Gene

Paralogs for ARHGEF25 Gene

Selected SIMAP similar genes for ARHGEF25 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with ARHGEF25: view

Variants for ARHGEF25 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF25 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs14561 -- 57,617,155(-) CCAGC(A/C)CTCCC utr-variant-3-prime, nc-transcript-variant
rs703833 -- 57,615,169(+) CTGGC(C/T)GAGGA intron-variant
rs1038914 -- 57,617,283(+) CTGTA(A/G)TGGGG downstream-variant-500B
rs1564374 - 57,616,380(+) AATTC(A/G/T)GCTTG missense, reference, nc-transcript-variant
rs1564375 -- 57,617,723(+) TTCCC(C/T)CAACA downstream-variant-500B

Relevant External Links for ARHGEF25 Gene

HapMap Linkage Disequilibrium report
ARHGEF25

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for ARHGEF25 Gene

Disorders for ARHGEF25 Gene

No disorders were found for ARHGEF25 Gene.

No data available for UniProtKB/Swiss-Prot for ARHGEF25 Gene

Publications for ARHGEF25 Gene

  1. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. (PMID: 12547822) Guo X. … Liu M. (J. Biol. Chem. 2003) 2 3 4 23
  2. p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. (PMID: 15069594) Lutz S. … Wieland T. (Naunyn Schmiedebergs Arch. Pharmacol. 2004) 3 4 23
  3. Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere. (PMID: 11861769) Souchet M. … Calmels T.P. (J. Cell Sci. 2002) 3 4
  4. The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. (PMID: 15632174) Lutz S. … Wieland T. (J. Biol. Chem. 2005) 3 4
  5. Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. (PMID: 16314529) Bryan B.A. … Liu M. (Mol. Cell. Biol. 2005) 3 4

Products for ARHGEF25 Gene

Sources for ARHGEF25 Gene

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