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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGEF25 Gene

protein-coding   GIFtS: 51
GCID: GC12P058004

Rho Guanine Nucleotide Exchange Factor (GEF) 25

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 251 2     GEFT2 3
RAC/CDC42 Exchange Factor1 2     p63RhoGEF2 3
Guanine Nucleotide Exchange Factor GEFT2 3     Rho Guanine Nucleotide Exchange Factor 252
Rac/Cdc42/Rho Exchange Factor GEFT2 3     RhoA/RAC/CDC42 Exchange Factor2
RhoA/Rac/Cdc42 Guanine Nucleotide Exchange Factor GEFT2 3     

External Ids:    HGNC: 302751   Entrez Gene: 1155572   Ensembl: ENSG000002407717   OMIM: 6102155   UniProtKB: Q86VW23   

Export aliases for ARHGEF25 gene to outside databases

Previous GC identifer: GC12P055041


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGEF25 Gene:
Rho GTPases alternate between an inactive GDP-bound state and an active GTP-bound state, and GEFs facilitate
GDP/GTP exchange. This gene encodes a guanine nucleotide exchange factor (GEF) which interacts with Rho GTPases
involved in contraction of vascular smooth muscles, regulation of responses to angiotensin II and lens cell
differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Jan 2012)

GeneCards Summary for ARHGEF25 Gene: 
ARHGEF25 (Rho guanine nucleotide exchange factor (GEF) 25) is a protein-coding gene. Diseases associated with ARHGEF25 include gout, and neuronitis, and among its related super-pathways are Signaling by GPCR and Gastrin-CREB signalling pathway via PKC and MAPK. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is KALRN.

UniProtKB/Swiss-Prot: ARHGP_HUMAN, Q86VW2
Function: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces
formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small
GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of
processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1.
Involved in skeletal myogenesis (By similarity)

Gene Wiki entry for ARHGEF25 (GEFT) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for ARHGEF25
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF25 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGEF25

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF25


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

ARHGEF25 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF25 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P058004:  view genomic region     (about GC identifiers)

Start:
58,003,963 bp from pter      End:
58,013,162 bp from pter
Size:
9,200 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARHGP_HUMAN, Q86VW2 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 25  
Size: 580 amino acids; 63843 Da
Subunit: Interacts (via the DH domain) with BVES (via the C-terminus cytoplasmic tail) (By similarity). Interacts
with activated GNAQ and GNA11. Interacts with RHOA, CDC42 and RAC1
Subcellular location: Cell membrane (By similarity). Cytoplasm, myofibril, sarcomere. Note=Highly colocalizes with
actin regions
1 PDB 3D structure from and Proteopedia for ARHGEF25:
2RGN (3D)    
Secondary accessions: A6NJH5 A9CQZ6 F8W7Z4 Q8WV84 Q96E63
Alternative splicing: 3 isoforms:  Q86VW2-1   Q86VW2-2   Q86VW2-3   

Explore the universe of human proteins at neXtProt for ARHGEF25: NX_Q86VW2

Explore proteomics data for ARHGEF25 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86VW2

  • ARHGEF25 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGEF25 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001104740.1  NP_891992.2  

    ENSEMBL proteins: 
     ENSP00000335560   ENSP00000286494  
    Reactome Protein details: Q86VW2
    Human Recombinant Protein Products for ARHGEF25: 
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    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0005886plasma membrane ISS--
    GO:0030016myofibril ISS--
    GO:0030017sarcomere IEA--

    ARHGEF25 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGEF: Rho guanine nucleotide exchange factors

    3 InterPro protein domains:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q86VW2

    ProtoNet protein and cluster: Q86VW2

    2 Blocks protein domains:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARHGP_HUMAN, Q86VW2
    Domain: The guanine nucleotide exchange activity is autoinhibited by the PH domain
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain


    ARHGEF25 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHGP_HUMAN, Q86VW2
    Function: May play a role in actin cytoskeleton reorganization in different tissues since its activation induces
    formation of actin stress fibers. It works as a guanine nucleotide exchange factor for Rho family of small
    GTPases. Links specifically G alpha q/11-coupled receptors to RHOA activation. May be an important regulator of
    processes involved in axon and dendrite formation. In neurons seems to be an exchange factor primarily for RAC1.
    Involved in skeletal myogenesis (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
         
    ARHGEF25 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGEF25:
     Synthetic lethal with c-Myc af  Upregulation of Wnt/beta-caten 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgef25):
     cardiovascular system  mortality/aging  normal 

    ARHGEF25 for phenotypes           About GeneDecksing

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGEF25 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Regulation of RhoA activity
    Regulation of RhoA activity
    4Regulation of RAC1 activity
    Regulation of RAC1 activity
    5Regulation of CDC42 activity
    Regulation of CDC42 activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    3 BioSystems Pathways for ARHGEF25
        Regulation of RhoA activity
    Regulation of CDC42 activity
    Regulation of RAC1 activity

    5        Reactome Pathways for ARHGEF25
        GPCR downstream signaling
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signal Transduction
    G alpha (q) signalling events
    Signaling by GPCR



    ARHGEF25 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGEF25

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/121 Interacting proteins for ARHGEF25 (Q86VW23 ENSP000003355604) via UniProtKB, MINT, STRING, and/or I2D (see all 121)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    CDC42P609533, ENSP000003144584I2D: score=2 STRING: ENSP00000314458
    RAC1P630003, ENSP000003484614I2D: score=2 STRING: ENSP00000348461
    AXIN2Q9Y2T13I2D: score=1 
    CSNK1A1P487293I2D: score=1 
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035023regulation of Rho protein signal transduction IEA--

    ARHGEF25 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARHGEF25 (ARHGP)

    Search CenterWatch for drugs/clinical trials and news about ARHGEF25 / ARHGP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ARHGEF25 gene (3 alternative transcripts): 
    NM_133483.2  NM_001111270.2  NM_182947.3  

    Unigene Cluster for ARHGEF25:

    Rho guanine nucleotide exchange factor (GEF) 25
    Hs.61581  [show with all ESTs]
    Unigene Representative Sequence: NR_046223
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000333972(uc009zpy.3 uc001soz.1) ENST00000286494(uc001spb.3 uc001spa.3)
    ENST00000471370 ENST00000469072 ENST00000466399 ENST00000484357 ENST00000477314

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    Additional mRNA sequence: 

    AB370196.1 AF487514.2 BC012860.1 BC018536.1 BC047559.1 NR_046223.1 

    6 DOTS entries:

    DT.454962  DT.100748921  DT.121109105  DT.95160261  DT.100733656  DT.121109103 

    24/122 AceView cDNA sequences (see all 122):

    BM748075 AA031486 BM510136 AW136644 AF331523 BM783700 BM750262 AI089627 
    BM783082 BX452641 AW161485 AI654427 AK057416 BM759898 CD722079 BM783529 
    CR624415 AA463846 BM783729 BM783095 AL536956 BX112080 BX097050 AA325176 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGEF25 expression in normal human tissues (normalized intensities)      ARHGEF25 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCCCCCCAA
    ARHGEF25 Expression
    About this image


    ARHGEF25 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             retinal progenitor cell e16.5   
     
     Testis (Reproductive System)
             Testicular Interstitial Cells Testis Interstitium

    See ARHGEF25 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGEF25

    SOURCE GeneReport for Unigene cluster: Hs.61581

    UniProtKB/Swiss-Prot: ARHGP_HUMAN, Q86VW2
    Tissue specificity: Isoform 1 and isoform 2 are highly expressed in excitable tissues, such as brain, heart and
    muscle. Also detected in kidney and liver

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF25 gene from 5/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef251 , 5 Rho guanine nucleotide exchange factor (GEF) 251, 5 86.19(n)1
    87.38(a)1
      10 (74.50 cM)5
    526661  NM_028027.31  NP_082303.21 
     1271825215 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF256
    --
    Uncharacterized protein
    43(a)
    1(a)
    1 ↔ 1
    possible ortholog
    GL343212.1(114489-209016)
    GL344614.1(950-10183)
    zebrafish
    (Danio rerio)
    Actinopterygii arhgef25b1 Rho guanine nucleotide exchange factor (GEF) 25b 59.25(n)
    58.94(a)
      569561  XM_692957.4  XP_698049.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta trio6
    CG158226
    --
    6(a)
    3(a)
    1 ↔ many
    possible ortholog
    3L(995982-1034875)
    3L(2153201-2163863)
    worm
    (Caenorhabditis elegans)
    Secernentea unc-736
    F55D12.26
    Protein F55D12.2, isoform a
    6(a)
    4(a)
    possible ortholog
    possible ortholog
    I(3999342-4031627)
    I(7889356-7894855)


    ENSEMBL Gene Tree for ARHGEF25 (if available)
    TreeFam Gene Tree for ARHGEF25 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGEF25 gene
    KALRN2  MCF2L22  PLEKHG4B2  TRIO2  MCF2L2  KIAA17552  PLEKHG42  ARHGEF402  
    MCF22  
    3 SIMAP similar genes for ARHGEF25 using alignment to 1 protein entry:     ARHGP_HUMAN:
    tgat    KALRN    TRIO

    ARHGEF25 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/283 SNPs in ARHGEF25 are shown (see all 283)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1382503721,2
    --57836321(+) CTTCAC/TATTTT 1 -- us2k10--------
    rs1843591941,2
    --57836439(+) AACACA/GTAAGG 1 -- us2k10--------
    rs3766571471,2
    C--57836745(+) AAGGCA/GTTTGA 1 -- us2k10--------
    rs2013654341,2
    C--57836770(+) TCACTA/GTCGGC 1 -- us2k10--------
    rs1120343031,2
    C,F--57836911(+) CATTTC/TCACTG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs23063901,2
    C,F,A,H--57836937(+) CCTCGC/TTCACG 1 -- us2k124Minor allele frequency- T:0.42EA NS NA WA 4070
    rs1429722191,2
    --57837015(+) TGGTCC/TTGGTG 1 -- us2k10--------
    rs1450392811,2
    --57837040(+) TACAAA/CAATAA 1 -- us2k10--------
    rs1388904881,2
    C--57837470(+) GAGCCA/GCTCCC 1 -- us2k10--------
    rs1174053001,2
    C,F--57837608(+) AAGGAC/TCTAGG 3 -- us2k11Minor allele frequency- T:0.01NA 120

    HapMap Linkage Disequilibrium report for ARHGEF25 (58003963 - 58013162 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for ARHGEF25: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGEF25
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610215    OMIM disorders: --

    2 diseases for ARHGEF25:    About MalaCards
    gout    neuronitis


    ARHGEF25 for disorders           About GeneDecksing


    Export disorders for ARHGEF25 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGEF25 gene, integrated from 9 sources (see all 20):
    (articles sorted by number of sources associating them with ARHGEF25)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A Rac/Cdc42-specific exchange factor, GEFT, induces cell proliferation, transformation, and migration. (PubMed id 12547822)1, 2, 3, 9 Guo X.... Liu M. (2003)
    2. p63RhoGEF and GEFT are Rho-specific guanine nucleotide exchange factors encoded by the same gene. (PubMed id 15069594)1, 2, 9 Lutz S....Wieland T. (2004)
    3. Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs. (PubMed id 18096806)1, 2 Lutz S....Tesmer J.J. (2007)
    4. The guanine nucleotide exchange factor p63RhoGEF, a specific link between Gq/11-coupled receptor signaling and RhoA. (PubMed id 15632174)1, 2 Lutz S.... Wieland T. (2005)
    5. Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT. (PubMed id 16314529)1, 2 Bryan B.A....Liu M. (2005)
    6. Human p63RhoGEF, a novel RhoA-specific guanine nucleotide exchange factor, is localized in cardiac sarcomere. (PubMed id 11861769)1, 2 Souchet M.... Calmels T.P. (2002)
    7. p63RhoGEF-mediated formation of a single polarized lam ellipodium is required for chemotactic migration in breast carcinoma cells. (PubMed id 23380069)1 Hayashi A....Mizuno K. (2013)
    8. p63RhoGEF couples GI+(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility. (PubMed id 21885830)1 Momotani K....Somlyo A.V. (2011)
    9. Plasma membrane association of p63 Rho guanine nucleo tide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells. (PubMed id 21832057)1 Aittaleb M....Tesmer J.J. (2011)
    10. GEFT, A Rho family guanine nucleotide exchange factor , regulates lens differentiation through a Rac1-mediated mechanism. (PubMed id 21663592)1 Mitchell D.C....Li D.W. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 115557 HGNC: 30275 AceView: GEFTandSLC26A10 Ensembl:ENSG00000240771 euGenes: HUgn115557
    ECgene: ARHGEF25 H-InvDB: ARHGEF25

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGEF25 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGEF25 gene:
    Search GeneIP for patents involving ARHGEF25

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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