Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ARHGEF2 Gene

protein-coding   GIFtS: 62
GCID: GC01M155916

Rho/Rac Guanine Nucleotide Exchange Factor (GEF) 2

(Previous name: rho/rac guanine nucleotide exchange factor (GEF) 2)
  Search for ARHGEF2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Rho/Rac Guanine Nucleotide Exchange Factor (GEF) 21 2     GEFH12 5
Guanine Nucleotide Exchange Factor H12 3     KIAA06513 5
Microtubule-Regulated Rho-GEF2 3     GEF2
Proliferating Cell Nucleolar Antigen P402 3     P402
GEF-H12 3     Rho Guanine Nucleotide Exchange Factor 22
LFP402 3     Rho/Rac Guanine Nucleotide Exchange Factor 22

External Ids:    HGNC: 6821   Entrez Gene: 91812   Ensembl: ENSG000001165847   OMIM: 6075605   UniProtKB: Q929743   
ORGUL members:         

Export aliases for ARHGEF2 gene to outside databases

Previous GC identifers: GC01M153779 GC01M151676 GC01M152694 GC01M153133 GC01M152729 GC01M154183 GC01M127277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for ARHGEF2 Gene:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli
that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate
rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been
identified.(provided by RefSeq, Jun 2009)

GeneCards Summary for ARHGEF2 Gene:
ARHGEF2 (Rho/Rac guanine nucleotide exchange factor (GEF) 2) is a protein-coding gene. GO annotations related to this gene include microtubule binding and phospholipid binding. An important paralog of this gene is ARHGEF3.

UniProtKB/Swiss-Prot: ARHG2_HUMAN, Q92974
Function: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier
permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell
differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem
to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May
stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an
intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by
pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell
invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent
of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which
requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway
promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial
peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the
tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2

Gene Wiki entry for ARHGEF2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGEF2 gene promoter:
         POU2F1   Sp1   p53   POU2F1a   FOXO1a   STAT5A   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARHGEF2 promoter sequence
   Search Chromatin IP Primers for ARHGEF2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q21-q22

ARHGEF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155916:  view genomic region     (about GC identifiers)

Start:
155,916,630 bp from pter      End:
155,976,861 bp from pter
Size:
60,232 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ARHG2_HUMAN, Q92974 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 2  
Size: 986 amino acids; 111543 Da
Subunit: Found in a complex composed at least of ARHGEF2, NOD2 and RIPK2. Interacts with RIPK2; the interaction
mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Interacts with RIPK1 and RIPK3. Interacts with
YWHAZ/14-3-3 zeta; when phosphorylated at Ser-886. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts
with RHOA and RAC1. Interacts with NOD1. Interacts (via the N-terminal zinc finger) with CAPN6 (via domain II)
(By similarity)
Sequence caution: Sequence=AAC97383.1; Type=Miscellaneous discrepancy; Note=Sequence differs at a large extent
from the sequence shown in the paper; Sequence=AAH20567.1; Type=Erroneous initiation; Note=Translation
N-terminally extended; Sequence=BAA31626.3; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAA33634.1; Type=Frameshift; Positions=887, 984;
Secondary accessions: D3DVA6 O75142 Q15079 Q5VY92 Q8TDA3 Q8WUG4 Q9H023
Alternative splicing: 3 isoforms:  Q92974-1   Q92974-2   Q92974-3   

Explore the universe of human proteins at neXtProt for ARHGEF2: NX_Q92974

Explore proteomics data for ARHGEF2 at MOPED

Post-translational modifications: 

  • Phosphorylation of Ser-886 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and
    the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its
    activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4
    releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a
    RIPK2-dependent manner1
  • Ubiquitination2 at Lys148, Lys438
  • Modification sites at PhosphoSitePlus

  • See ARHGEF2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001155855.1  NP_001155856.1  NP_004714.2  

    ENSEMBL proteins: 
     ENSP00000315325   ENSP00000354837   ENSP00000476916   ENSP00000476689   ENSP00000314787  
     ENSP00000477448   ENSP00000477299   ENSP00000476724   ENSP00000476699   ENSP00000476532  
     ENSP00000476518   ENSP00000357298   ENSP00000357299  
    Reactome Protein details: Q92974

    ARHGEF2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ARHGEF2
    OriGene Protein Over-expression Lysate for ARHGEF2
    OriGene MassSpec for ARHGEF2
    OriGene Custom Protein Services for ARHGEF2
    GenScript Custom Purified and Recombinant Proteins Services for ARHGEF2
    Novus Biologicals ARHGEF2 Proteins
    Novus Biologicals ARHGEF2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARHGEF2

     
    Search eBioscience for Proteins for ARHGEF2 

    ARHGEF2 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ARHGEF2
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ARHGEF2 
    OriGene Antibodies for ARHGEF2
    OriGene Custom Antibody Services for ARHGEF2
    Novus Biologicals ARHGEF2 Antibodies
    Abcam antibodies for ARHGEF2
    Cloud-Clone Corp. Antibodies for ARHGEF2
    ThermoFisher Antibody for ARHGEF2
    LSBio Antibodies in human, mouse, rat for ARHGEF2

    ARHGEF2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARHGEF2
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGEF2
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARHGEF2
    Cloud-Clone Corp. CLIAs for ARHGEF2
    Search eBioscience for ELISAs for ARHGEF2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    5 InterPro protein domains:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR015721 RhoGEF-like
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd

    Graphical View of Domain Structure for InterPro Entry Q92974

    ProtoNet protein and cluster: Q92974

    2 Blocks protein domains:
    IPB000219 DH domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARHG2_HUMAN, Q92974
    Domain: The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA. Promotes tyrosine
    phosphorylation of RIPK2
    Domain: The PH (pleckstrin-homology) domain is involved in microtubule binding and targeting to tight junctions
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger


    Find genes that share domains with ARHGEF2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHG2_HUMAN, Q92974
    Function: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier
    permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell
    differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem
    to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May
    stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an
    intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by
    pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell
    invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent
    of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which
    requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway
    promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial
    peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the
    tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2
    Induction: Up-regulated by bacterial peptidoglycans stimulation, such as muramyl dipeptide and in biopsies from
    inflamed mucosal areas of Crohn's disease patients

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IDA9857026
    GO:0005515protein binding IPI14970201
    GO:0008017microtubule binding IDA9857026
    GO:0008134transcription factor binding ISS--
    GO:0008270zinc ion binding NAS11912491
         
    Find genes that share ontologies with ARHGEF2           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Arhgef2 (no phenotypes)

    Find genes that share phenotypes with ARHGEF2           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGEF2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGEF2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGEF2

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARHGEF2:
    hsa-mir-96-5p (MIRT027914), hsa-mir-423-3p (MIRT042542), hsa-mir-320a (MIRT044440), hsa-mir-744-5p (MIRT037439), hsa-mir-877-3p (MIRT037159), hsa-mir-335-5p (MIRT018030)

    Block miRNA regulation of human, mouse, rat ARHGEF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF2 (see all 30):
    hsa-miR-142-3p hsa-miR-3910 hsa-miR-3128 hsa-miR-607 hsa-miR-1263 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-218-1*
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARHGEF2
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF2

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARHGEF2

    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGEF2 (see all 18)
    OriGene ORF clones in mouse, rat for ARHGEF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ARHGEF2 (NM_004723)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF2

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARHGEF2
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARHGEF2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ARHG2_HUMAN, Q92974: Cytoplasm. Cell junction, tight junction. Golgi apparatus. Cytoplasm, cytoskeleton, spindle.
    Cell projection, ruffle membrane. Cytoplasmic vesicle. Note=Localizes to the tips of cortical microtubules of the
    mitotic spindle during cell division, and is further released upon microtubule depolymerization. Recruited into
    membrane ruffles induced by S.flexneri at tight junctions of polarized epithelial cells. Colocalized with NOD2
    and RIPK2 in vesicles and with the cytoskeleton
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    plasma membrane5
    cytosol4
    nucleus3

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IEA--
    GO:0005819spindle IEA--
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton IDA--

    Find genes that share ontologies with ARHGEF2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ARHGEF2 About   (see all 27)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Pathogenic Escherichia coli infection0.43
    Pathogenic Escherichia coli infection0.41
    2p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    G alpha (12/13) signalling events0.44
    3GPCR Pathway
    Ras Pathway0.73
    Pancreatic Adenocarcinoma0.59
    GPCR Pathway0.62
    Breast Cancer Regulation by Stathmin10.58
    4Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    5G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    Thrombin Signaling0.40
    G-AlphaI Signaling0.47


    Find genes that share SuperPaths with ARHGEF2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGEF2 (see all 22)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling

    1 Cell Signaling Technology (CST) Pathway for ARHGEF2
        Cytoskeletal Signaling

    3 GeneGo (Thomson Reuters) Pathways for ARHGEF2
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling RhoB regulation pathway
    G-protein signaling RhoA regulation pathway

    4 BioSystems Pathways for ARHGEF2
        Pathogenic Escherichia coli infection
    Reelin signaling pathway
    Regulation of RhoA activity
    Regulation of RAC1 activity

    3 Reactome Pathways for ARHGEF2
        G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle


    1 Kegg Pathway  (Kegg details for ARHGEF2):
        Pathogenic Escherichia coli infection

        Pathway & Disease-focused RT2 Profiler PCR Array including ARHGEF2: 
              Tight Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARHGEF2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGEF2 (Q929741, 2, 3 ENSP000003153254) via UniProtKB, MINT, STRING, and/or I2D (see all 860)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PAK1Q131532, 3, ENSP000002785684MINT-7945693 I2D: score=3 STRING: ENSP00000278568
    YWHAEP622582, 3, ENSP000002643354MINT-7947479 I2D: score=2 STRING: ENSP00000264335
    YWHAZP631041, 2, 3, ENSP000003095034EBI-302405,EBI-347088 MINT-3295597 MINT-8006660 I2D: score=3 STRING: ENSP00000309503
    ARHGEF1Q928882, ENSP000003372614MINT-7945693 MINT-7947479 STRING: ENSP00000337261
    ROCK2O751162, ENSP000003179854MINT-7945693 MINT-7947479 STRING: ENSP00000317985
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 30):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000132establishment of mitotic spindle orientation IEA--
    GO:0000902cell morphogenesis IMP11912491
    GO:0006886intracellular protein transport NAS9857026
    GO:0007015actin filament organization IMP9857026
    GO:0007026negative regulation of microtubule depolymerization IMP11912491

    Find genes that share ontologies with ARHGEF2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGEF2 (ARHG2)

    Selected HMDB Compounds for ARHGEF2 (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    Selected Novoseek inferred chemical compound relationships for ARHGEF2 gene (see all 22)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 85.5 45 15850775 (3), 8049218 (2), 7988425 (2), 7581745 (2) (see all 29)
    gtp 80.3 44 8049218 (3), 19356586 (3), 10608844 (2), 7581745 (2) (see all 29)
    guanine 64.5 20 11747824 (1), 16143467 (1), 18470881 (1), 16248653 (1) (see all 17)
    guanosine 54.5 6 9671484 (1), 19000755 (1), 19103205 (1)
    tyrosine 52.9 21 10882715 (3), 10652228 (2), 9099726 (2), 10681520 (1) (see all 16)
    phosphoinositide 40.7 6 9671484 (1), 17007612 (1), 17698854 (1), 12525493 (1) (see all 6)
    phosphatidylinositol 29.8 2 17698854 (1), 20167601 (1)
    phosphatidylinositol-3,4,5-trisphosphate 28.7 2 10848997 (1), 12923183 (1)
    cyclic amp 22.5 3 19273589 (2)
    tech 20.9 2 15686487 (1), 15953360 (1)



    Find genes that share compounds with ARHGEF2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ARHGEF2 gene (3 alternative transcripts): 
    NM_001162383.1  NM_001162384.1  NM_004723.3  

    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000313695(uc001fmr.2) ENST00000361247(uc001fms.2 uc001fmt.2)
    ENST00000462460(uc010pgt.1) ENST00000477754 ENST00000470541(uc001fmq.2)
    ENST00000313667 ENST00000474428 ENST00000470975 ENST00000608543 ENST00000470874
    ENST00000471589 ENST00000497907 ENST00000476273 ENST00000609707 ENST00000487755
    ENST00000465079 ENST00000495070 ENST00000423422
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARHGEF2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF2 (see all 30):
    hsa-miR-142-3p hsa-miR-3910 hsa-miR-3128 hsa-miR-607 hsa-miR-1263 hsa-miR-199b-3p hsa-miR-199a-3p hsa-miR-218-1*
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARHGEF2
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF2
    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGEF2 (see all 18)
    OriGene ORF clones in mouse, rat for ARHGEF2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ARHGEF2 (NM_004723)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF2
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARHGEF2
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGEF2
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF2
      QuantiFast Probe-based Assays in human, mouse, rat ARHGEF2

    Selected AceView cDNA sequences (see all 293):

    BM476546 AA235631 AK127366 CO246749 BM931035 BF901364 AI811316 AF486838 
    BM671198 AA505099 BE501440 BM545150 BC020567 AB014551 CA424226 BG315198 
    AW878570 AA377474 NM_004723 BG150054 BU170796 AI420010 BG060019 BM717720 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF2 (see all 7)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                    -     -           -                                                           -                                                         
    SP2:                    -     -           -                                                           -                                                         
    SP3:                          -           -                                                           -                                                         
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24a · 24b ^ 25a · 25b
    SP1:              -               
    SP2:              -               
    SP3:              -               
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for ARHGEF2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ARHGEF2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTGAAACC
    ARHGEF2 Expression
    About this image


    ARHGEF2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Lung (Respiratory System)
     
     Testis (Reproductive System)
     
     Spleen (Hematopoietic System)
    ARHGEF2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGEF2 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including ARHGEF2: 
              Tight Junctions in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARHGEF2
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGEF2
    QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF2
    QuantiFast Probe-based Assays in human, mouse, rat ARHGEF2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef21 , 5 rho/rac guanine nucleotide exchange factor (GEF) 21, 5 84.93(n)1
    88.82(a)1
      3 (38.90 cM)5
    168001  NM_008487.31  NP_032513.31 
     886074545 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF26
    Rho/Rac guanine nucleotide exchange factor (GEF) 2...
    74(a)
    1 ↔ 1
    AAWZ02038914(24-9267)
    African clawed frog
    (Xenopus laevis)
    Amphibia AF159239.12   -- 75(n)    AF159239.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgef21 rho/rac guanine nucleotide exchange factor (GEF) 2 62.1(n)
    62.23(a)
      561276  XM_684678.6  XP_689770.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG101886
    --
    16(a)
    1 → many
    2L(19502335-19508760)


    ENSEMBL Gene Tree for ARHGEF2 (if available)
    TreeFam Gene Tree for ARHGEF2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ARHGEF2 gene
    ARHGEF32  ARHGEF112  ARHGEF12  ENSG000002688612  NET12  ARHGEF122  AKAP132  ARHGEF182  
    ARHGEF282  
    4 SIMAP similar genes for ARHGEF2 using alignment to 10 protein entries:     ARHG2_HUMAN (see all proteins):
    AKAP13    ARHGEF28    ARHGEF18    ARHGEF1

    Find genes that share paralogs with ARHGEF2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ARHGEF2 (see all 616)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1813240771,2
    --155916244(+) TGAGCA/TGCTCC 3 -- ds50010--------
    rs1854572071,2
    --155916256(+) GTGACA/GGGTAA 3 -- ds50010--------
    rs1491368601,2
    --155916588(+) TGCCCG/TGCTCT 3 -- ds50010--------
    rs2009090001,2
    --155916675(+) CTGAA-/TTTTTT 3 -- ut310--------
    rs120373991,2
    C,H--155916900(+) CCCCCA/C/GGTTAC 6 -- ut316NS EA NA 602
    rs1432578351,2
    --155917172(+) TTCCAC/TGAAGG 3 -- ut310--------
    rs412649951,2
    C,F--155917389(+) ACAAGG/CCCCTC 3 -- ut313Minor allele frequency- C:0.14NA 124
    rs50235141,2
    C,H--155917412(+) CTTGGT/GTCCCA 3 -- ut31 ese36Minor allele frequency- G:0.00NS EA NA 422
    rs727082171,2
    C,F--155917592(+) CCAGGT/AATCCA 3 -- ut312Minor allele frequency- A:0.05CSA NA 121
    rs2009763951,2
    --155917684(+) AGCCCA/CCTCAG 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ARHGEF2 (155916630 - 155976861 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for ARHGEF2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv509513CNV Insertion20534489
    esv33869CNV Loss17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGEF2
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGEF2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607560    OMIM disorders: --


    Find genes that share disorders with ARHGEF2           About GenesLikeMe

    Selected Novoseek inferred disease relationships for ARHGEF2 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    spastic paralysis 66.3 1 14668431 (1)
    motor neuron disease 46.7 1 14668431 (1)
    primary lateral sclerosis 39.7 1 14668431 (1)
    amyotrophic lateral sclerosis 31.2 1 14668431 (1)
    dysplasia 23.2 2 20045932 (1), 18363964 (1)
    shock 0 3 17113038 (1), 16875662 (1)
    breast cancer 0 1 18084281 (1)
    metastasis 0 3 18470881 (1), 20361982 (1), 9348295 (1)
    demyelination 0 1 17564972 (1)
    tumors 0 1 18470881 (1)

    Genetic Association Database (GAD): ARHGEF2
    Human Genome Epidemiology (HuGE) Navigator: ARHGEF2 (3 documents)

    Export disorders for ARHGEF2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ARHGEF2 gene, integrated from 10 sources (see all 360):
    (articles sorted by number of sources associating them with ARHGEF2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. (PubMed id 9857026)1, 2, 3, 9 Ren Y.... Busch H. (J. Biol. Chem. 1998)
    2. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    3. PAK4 mediates morphological changes through the regulation of GEF- H1. (PubMed id 15827085)1, 2, 9 Callow M.G.... Smeal T. (J. Cell Sci. 2005)
    4. Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1. (PubMed id 21887730)1, 2 Zhao Y....Reinecker H.C. (Inflamm. Bowel Dis. 2012)
    5. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    6. GEF-H1 mediated control of NOD1 dependent NF-kappaB activation by Shigella effectors. (PubMed id 19043560)1, 2 Fukazawa A.... Reinecker H.C. (PLoS Pathog. 2008)
    7. ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA. (PubMed id 18211802)1, 2 Fujishiro S.H....Kohno M. (Biochem. Biophys. Res. Commun. 2008)
    8. Use of expression data and the CGEMS genome-wide breast cancer association study to identify genes that may modify risk in BRCA1/2 mutation carriers. (PubMed id 18095154)1, 4 Walker L.C....Spurdle A.B. (Breast Cancer Res. Treat. 2008)
    9. GEF-H1 modulates localized RhoA activation during cytokinesis under the control of mitotic kinases. (PubMed id 17488622)1, 2 Birkenfeld J....Bokoch G.M. (Dev. Cell 2007)
    10. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (Nat. Biotechnol. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9181 HGNC: 682 AceView: ARHGEF2 Ensembl:ENSG00000116584 euGenes: HUgn9181
    ECgene: ARHGEF2 Kegg: 9181 H-InvDB: ARHGEF2

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0651

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ARHGEF2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARHGEF2 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/ARHGEF2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARHGEF2 gene:
    Search GeneIP for patents involving ARHGEF2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of ARHGEF2
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ARHGEF2   OriGene RNAi products in human, mouse, rat for ARHGEF2  
     OriGene qPCR primer pairs and template standards for ARHGEF2   OriGene Protein Over-expression Lysate for ARHGEF2  
     OriGene MassSpec something-or-other for ARHGEF2   OriGene clones in human, mouse for ARHGEF2  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF2   OriGene Purified Protein for ARHGEF2  
     OriGene ORF clones in mouse, rat for ARHGEF2   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARHGEF2   OriGene Custom Protein Services for ARHGEF2  

     
     
     Block miRNA regulation of human, mouse, rat ARHGEF2 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ARHGEF2
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF2 Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF2
     QuantiFast Probe-based Assays in human, mouse, rat ARHGEF2 QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF2
     PCR Arrays including human, mouse, rat ARHGEF2 Search Chromatin IP Primers for ARHGEF2
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGEF2  GeneGlobe Interaction Network for ARHGEF2
     Regulatory tfbs in ARHGEF2 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ARHGEF2 GenScript cDNA clones with any tag delivered in your preferred vector for ARHGEF2
     GenScript Custom Assay Services for ARHGEF2 GenScript Custom overexpressing Cell Line Services for ARHGEF2
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Antibodies & Assays for ARHGEF2 

     Search Tocris compounds for ARHGEF2 (ARHG2)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ARHGEF2 antibodies
     ARHGEF2 proteins
     ARHGEF2 lysates
     Antibodies for ARHGEF2
     See all of Abcam's Antibodies, Kits and Proteins for ARHGEF2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ARHGEF2
     Antibodies for ARHGEF2
     ELISAs for ARHGEF2
     CLIAs for ARHGEF2



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARHGEF2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF2
     SwitchGear 3'UTR luciferase reporter plasmids for ARHGEF2
     SwitchGear Promoter luciferase reporter plasmids for ARHGEF2
     ThermoFisher Antibody for ARHGEF2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF2
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF2
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGEF2
     LSBio Antibodies in human, mouse, rat for ARHGEF2
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for ARHGEF2
      Search eBioscience for proteins for ARHGEF2
      Search eBioscience for elisas for ARHGEF2
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARHGEF2 gene at Home site.
    Version: 3.12.210 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4