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Aliases for ARHGEF2 Gene

Aliases for ARHGEF2 Gene

  • Rho/Rac Guanine Nucleotide Exchange Factor 2 2 3 5
  • Rho/Rac Guanine Nucleotide Exchange Factor (GEF) 2 2 3
  • Proliferating Cell Nucleolar Antigen P40 3 4
  • Guanine Nucleotide Exchange Factor H1 3 4
  • Microtubule-Regulated Rho-GEF 3 4
  • GEF-H1 3 4
  • LFP40 3 4
  • Rho Guanine Nucleotide Exchange Factor 2 3
  • KIAA0651 4
  • NEDMHM 3
  • GEFH1 3
  • GEF 3
  • P40 3

External Ids for ARHGEF2 Gene

Previous GeneCards Identifiers for ARHGEF2 Gene

  • GC01M153779
  • GC01M151676
  • GC01M152694
  • GC01M153133
  • GC01M152729
  • GC01M154183
  • GC01M155916
  • GC01M127277

Summaries for ARHGEF2 Gene

Entrez Gene Summary for ARHGEF2 Gene

  • Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate rho-dependent signals. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Jun 2009]

GeneCards Summary for ARHGEF2 Gene

ARHGEF2 (Rho/Rac Guanine Nucleotide Exchange Factor 2) is a Protein Coding gene. Diseases associated with ARHGEF2 include Neurodevelopmental Disorder With Midbrain And Hindbrain Malformations and Unilateral Focal Polymicrogyria. Among its related pathways are p75 NTR receptor-mediated signalling and Phospholipase-C Pathway. GO annotations related to this gene include transcription factor binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is AKAP13.

UniProtKB/Swiss-Prot for ARHGEF2 Gene

  • Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.

Gene Wiki entry for ARHGEF2 Gene

Additional gene information for ARHGEF2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF2 Gene

Genomics for ARHGEF2 Gene

Regulatory Elements for ARHGEF2 Gene

Enhancers for ARHGEF2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H155965 1.8 FANTOM5 ENCODE dbSUPER 27.6 +31.7 31694 19 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 RIT1 KIAA0907 ARHGEF2 GON4L CLK2 PAQR6 PRCC RRNAD1 YY1AP1 ENSG00000271267
GH01H155937 2 FANTOM5 Ensembl ENCODE dbSUPER 15.1 +63.9 63851 10 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B FEZF1 DMAP1 SLC30A9 ZNF143 GON4L CLK2 RIT1 KIAA0907 RRNAD1 ENSG00000271267 YY1AP1 ARHGEF2 RUSC1-AS1 FLAD1
GH01H156165 1.2 FANTOM5 ENCODE dbSUPER 24.5 -158.3 -158308 0 BCOR IKZF1 KDM1A MLLT1 SPI1 RELA ARHGEF2 SLC25A44 ENSG00000252236 RIT1 LOC107985210 LMNA MEX3A SEMA4A YY1AP1 MEF2D
GH01H156456 1.8 FANTOM5 ENCODE dbSUPER 11.9 -450.3 -450307 2 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 KIAA0907 GON4L ENSG00000271267 LOC246784 RRNAD1 ASH1L LMNA MSTO2P DAP3P1 ENSG00000229961
GH01H155958 1.4 Ensembl ENCODE dbSUPER 12.8 +45.9 45941 4 TBL1XR1 NFIB INSM2 KLF17 SIN3A RAD21 RCOR1 FOS RUNX3 IKZF2 RIT1 LOC107985210 ARHGEF2 KIAA0907 SCARNA4 UBQLN4 LAMTOR2 LOC107985209 MIR6738
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGEF2 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGEF2 Gene

Chromosome:
1
Start:
155,946,640 bp from pter
End:
156,007,070 bp from pter
Size:
60,431 bases
Orientation:
Minus strand

Genomic View for ARHGEF2 Gene

Genes around ARHGEF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF2 Gene

Proteins for ARHGEF2 Gene

  • Protein details for ARHGEF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92974-ARHG2_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 2
    Protein Accession:
    Q92974
    Secondary Accessions:
    • D3DVA6
    • O75142
    • Q15079
    • Q5VY92
    • Q8TDA3
    • Q8WUG4
    • Q9H023

    Protein attributes for ARHGEF2 Gene

    Size:
    986 amino acids
    Molecular mass:
    111543 Da
    Quaternary structure:
    • Found in a complex composed at least of ARHGEF2, NOD2 and RIPK2. Interacts with RIPK2; the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Interacts with RIPK1 and RIPK3. Interacts with YWHAZ/14-3-3 zeta; when phosphorylated at Ser-886. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1. Interacts (via the N-terminal zinc finger) with CAPN6 (via domain II). Interacts with DYNLT1 (By similarity).
    SequenceCaution:
    • Sequence=AAC97383.1; Type=Miscellaneous discrepancy; Note=Sequence differs at a large extent from the sequence shown in the paper.; Evidence={ECO:0000305}; Sequence=AAH20567.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA31626.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAA33634.1; Type=Frameshift; Positions=887, 984; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGEF2 Gene

    Alternative splice isoforms for ARHGEF2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF2 Gene

Post-translational modifications for ARHGEF2 Gene

  • Phosphorylation of Ser-886 by PAK1 induces binding to protein YWHAZ, promoting its relocation to microtubules and the inhibition of its activity. Phosphorylated by AURKA and CDK1 during mitosis, which negatively regulates its activity. Phosphorylation by MAPK1 or MAPK3 increases nucleotide exchange activity. Phosphorylation by PAK4 releases GEF-H1 from the microtubules. Phosphorylated on serine, threonine and tyrosine residues in a RIPK2-dependent manner.
  • Ubiquitination at posLast=148148 and Lys438
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGEF2 Gene

Domains & Families for ARHGEF2 Gene

Gene Families for ARHGEF2 Gene

Protein Domains for ARHGEF2 Gene

Graphical View of Domain Structure for InterPro Entry

Q92974

UniProtKB/Swiss-Prot:

ARHG2_HUMAN :
  • The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA. Promotes tyrosine phosphorylation of RIPK2.
Domain:
  • The DH (DBL-homology) domain interacts with and promotes loading of GTP on RhoA. Promotes tyrosine phosphorylation of RIPK2.
  • The PH domain has no affinity for phosphoinositides suggesting that it does not interact directly with membranes.
  • The phorbol-ester/DAG-type zinc-finger and the C-terminal coiled-coil domains (606-986) are both important for association with microtubules.
genes like me logo Genes that share domains with ARHGEF2: view

Function for ARHGEF2 Gene

Molecular function for ARHGEF2 Gene

UniProtKB/Swiss-Prot Function:
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.
UniProtKB/Swiss-Prot Induction:
Up-regulated by bacterial peptidoglycans stimulation, such as muramyl dipeptide and in biopsies from inflamed mucosal areas of Crohns disease patients.

Phenotypes From GWAS Catalog for ARHGEF2 Gene

Gene Ontology (GO) - Molecular Function for ARHGEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005515 protein binding IPI 14970201
GO:0008017 microtubule binding IDA 9857026
GO:0008134 transcription factor binding ISS --
genes like me logo Genes that share ontologies with ARHGEF2: view
genes like me logo Genes that share phenotypes with ARHGEF2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARHGEF2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF2 Gene

Localization for ARHGEF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF2 Gene

Cytoplasm, cytoskeleton. Cytoplasm. Cell junction, tight junction. Golgi apparatus. Cytoplasm, cytoskeleton, spindle. Cell projection, ruffle membrane. Cytoplasmic vesicle. Note=Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization (PubMed:15827085). Recruited into membrane ruffles induced by S.flexneri at tight junctions of polarized epithelial cells (PubMed:19043560). Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton (PubMed:21887730). {ECO:0000269 PubMed:15827085, ECO:0000269 PubMed:19043560, ECO:0000269 PubMed:21887730}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF2 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
nucleus 4
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for ARHGEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002102 podosome IEA --
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA,IDA 21887730
GO:0005794 Golgi apparatus IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with ARHGEF2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for ARHGEF2 Gene

Pathways & Interactions for ARHGEF2 Gene

genes like me logo Genes that share pathways with ARHGEF2: view

SIGNOR curated interactions for ARHGEF2 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ARHGEF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000132 establishment of mitotic spindle orientation IEA --
GO:0000902 cell morphogenesis IMP 11912491
GO:0002376 immune system process IEA --
GO:0006886 intracellular protein transport NAS 9857026
GO:0007015 actin filament organization IMP 9857026
genes like me logo Genes that share ontologies with ARHGEF2: view

Drugs & Compounds for ARHGEF2 Gene

(15) Drugs for ARHGEF2 Gene - From: ApexBio, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
NSC 23766 Pharma Selective inhibitor of Rac1-GEF interaction., Selective inhibitor of Rac1-GEF interaction; antioncogenic 0

(13) Additional Compounds for ARHGEF2 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(1) ApexBio Compounds for ARHGEF2 Gene

Compound Action Cas Number
NSC 23766 Selective inhibitor of Rac1-GEF interaction. 1177865-17-6
genes like me logo Genes that share compounds with ARHGEF2: view

Drug Products

Transcripts for ARHGEF2 Gene

Unigene Clusters for ARHGEF2 Gene

Rho/Rac guanine nucleotide exchange factor (GEF) 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for ARHGEF2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
SP1: - - - -
SP2: - - - -
SP3: - - -
SP4:
SP5:
SP6: - - - - -
SP7:

ExUns: 23 ^ 24a · 24b ^ 25a · 25b
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:

Relevant External Links for ARHGEF2 Gene

GeneLoc Exon Structure for
ARHGEF2
ECgene alternative splicing isoforms for
ARHGEF2

Expression for ARHGEF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARHGEF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF2 Gene

This gene is overexpressed in Whole Blood (x4.1).

Protein differential expression in normal tissues from HIPED for ARHGEF2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (16.3), Frontal cortex (7.7), Lymph node (7.7), and Brain (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGEF2 Gene



Protein tissue co-expression partners for ARHGEF2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF2 Gene:

ARHGEF2

SOURCE GeneReport for Unigene cluster for ARHGEF2 Gene:

Hs.743352

Evidence on tissue expression from TISSUES for ARHGEF2 Gene

  • Nervous system(4.5)
  • Blood(4.3)
  • Liver(4.2)
  • Lung(3.1)
  • Heart(2.2)
genes like me logo Genes that share expression patterns with ARHGEF2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for ARHGEF2 Gene

Orthologs for ARHGEF2 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF2 33 34
  • 99.49 (n)
cow
(Bos Taurus)
Mammalia ARHGEF2 33 34
  • 90.93 (n)
dog
(Canis familiaris)
Mammalia ARHGEF2 33 34
  • 88.19 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF2 34
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef2 33
  • 85.2 (n)
mouse
(Mus musculus)
Mammalia Arhgef2 33 16 34
  • 84.93 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGEF2 34
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef2 33
  • 66.29 (n)
zebrafish
(Danio rerio)
Actinopterygii arhgef2 33 34
  • 62.1 (n)
arhgef1a 34
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10188 34
  • 16 (a)
OneToMany
Species where no ortholog for ARHGEF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF2 Gene

ENSEMBL:
Gene Tree for ARHGEF2 (if available)
TreeFam:
Gene Tree for ARHGEF2 (if available)

Paralogs for ARHGEF2 Gene

genes like me logo Genes that share paralogs with ARHGEF2: view

Variants for ARHGEF2 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000200811 -- 155,984,202(+) GCCCA(C/T)CCAAA intron-variant, upstream-variant-2KB
rs1000216692 -- 155,975,653(+) TAGTC(C/T)TGCAC intron-variant
rs1000255798 -- 155,980,911(+) AGTCT(C/T)GGCCA intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000311177 -- 155,946,673(+) TGAAT(G/T)AAAAA downstream-variant-500B
rs1000361967 -- 155,947,135(+) AAGTC(A/G)TTCTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF2 Gene

Variant ID Type Subtype PubMed ID
esv33869 CNV loss 17666407
nsv509513 CNV insertion 20534489

Variation tolerance for ARHGEF2 Gene

Residual Variation Intolerance Score: 3.18% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF2 Gene

Human Gene Mutation Database (HGMD)
ARHGEF2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF2 Gene

Disorders for ARHGEF2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for ARHGEF2 Gene - From: HGMD, OMIM, ClinVar, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGEF2

Genetic Association Database (GAD)
ARHGEF2
Human Genome Epidemiology (HuGE) Navigator
ARHGEF2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF2
genes like me logo Genes that share disorders with ARHGEF2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGEF2 Gene

Publications for ARHGEF2 Gene

  1. Cloning and characterization of GEF-H1, a microtubule-associated guanine nucleotide exchange factor for Rac and Rho GTPases. (PMID: 9857026) Ren Y … Busch H (The Journal of biological chemistry 1998) 2 3 4 22 60
  2. PAK4 mediates morphological changes through the regulation of GEF-H1. (PMID: 15827085) Callow MG … Smeal T (Journal of cell science 2005) 3 4 22 60
  3. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1998) 2 3 4 60
  4. Crystal structure of hGEF-H1 PH domain provides insight into incapability in phosphoinositide binding. (PMID: 26820534) Jiang Y … Ouyang S (Biochemical and biophysical research communications 2016) 3 4 60
  5. Control of NOD2 and Rip2-dependent innate immune activation by GEF-H1. (PMID: 21887730) Zhao Y … Reinecker HC (Inflammatory bowel diseases 2012) 3 4 60

Products for ARHGEF2 Gene

Sources for ARHGEF2 Gene