ARHGEF18 Gene
protein-coding GIFtS: 57
GCID: GC19P007459
|
|
Rho/Rac guanine nucleotide exchange factor (GEF) 18(Previous name: rho/rac guanine nucleotide exchange factor (GEF) 18 )
| |
Aliases
for ARHGEF18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho/Rac Guanine Nucleotide Exchange Factor (GEF) 181 2 | | P114-RHO-GEF2 | | P114-RhoGEF1 2 | | Rho Guanine Nucleotide Exchange Factor 182 | | KIAA05211 3 | | Rho-Specific Guanine Nucleotide Exchange Factor P1142 | | Septin-Associated RhoGEF2 3 | | Rho/Rac Guanine Nucleotide Exchange Factor 182 | | 114 KDa Rho-Specific Guanine Nucleotide Exchange Factor2 3 | | P114-Rho-GEF1 | | SA-RhoGEF2 3 | | EC 3.4.248 | | P114RhoGEF1 | | EC 3.6.18 | | MGC159131 | | |
Export aliases for ARHGEF18 gene to outside databasesPrevious GC identifers: GC19P007366 GC19P007351 GC19P007128 |
Summaries
for ARHGEF18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARHGEF18:
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processesinclude cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is underthe direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guaninenucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH)homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encodingdifferent isoforms have been identified. (provided by RefSeq, Oct 2008)
UniProtKB/Swiss-Prot: ARHGI_HUMAN, Q6ZSZ5Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeletonreorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEFfor RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G proteinbeta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects ofLPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROSproduction
|
Genomic Views
for ARHGEF18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_077812.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGEF18 gene promoter:
ER-alpha NRSF form 2 E4BP4 AP-2gamma Evi-1 AP-2beta SEF-1 (1) ZID AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGEF18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.3ARHGEF18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P007459: view genomic region
(about GC identifiers)
Start:
|
7,459,999 bp from pter |
End:
|
7,537,371 bp from pter |
Size:
|
77,373 bases |
Orientation:
|
plus strand |
|
Proteins
for ARHGEF18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARHGI_HUMAN, Q6ZSZ5 (See
protein sequence)Recommended Name: Rho guanine nucleotide exchange factor 18 Size: 1173 amino acids; 130780 Da
Subunit: Interacts with SEPT9; interaction may inhibit GEF activity. Interacts with Gbetagamma subunits GNB1 and GNG2
Subcellular location: Cytoplasm. Note=Colocalizes with actin stress fibers
Sequence caution: Sequence=AAH77721.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing; Sequence=BAA25447.1;Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8MV62 B5ME81 O60274 Q6DD92Alternative splicing: 2 isoforms: Q6ZSZ5-1 Q6ZSZ5-2 Explore the universe of human proteins at neXtProt for ARHGEF18: NX_Q6ZSZ5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZSZ5
2 DME Specific Peptides for ARHGEF18 (Q6ZSZ5)
ARHGEF18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001124427.1 NP_056133.2
ENSEMBL proteins: ENSP00000352995 ENSP00000319200 Reactome Protein details: Q6ZSZ5
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
ARHGEF18 for ontologies About GeneDecksing
ARHGEF18 Antibody Products:
Assay Products for ARHGEF18: |
Protein
Domains /
Families
for ARHGEF18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGEF18 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ZSZ5ProtoNet protein and cluster: Q6ZSZ5 2 Blocks protein families: IPB000219 DH domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: ARHGI_HUMAN, Q6ZSZ5Similarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 1 PH domain |
Function
for ARHGEF18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARHGI_HUMAN, Q6ZSZ5Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases. May play a role in actin cytoskeletonreorganization in different tissues since its activation induces formation of actin stress fibers. Also act as a GEFfor RAC1, inducing production of reactive oxygen species (ROS). Does not act as a GEF for CDC42. The G proteinbeta-gamma (Gbetagamma) subunits of heterotrimeric G proteins act as activators, explaining the integrated effects ofLPA and other G-protein coupled receptor agonists on actin stress fiber formation, cell shape change and ROSproductionEnzyme Numbers (IUBMB): EC 3.6.12 EC 3.4.242
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF18 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ARHGEF18 (NM_015318) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF18 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF18 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity |
IDA | 14512443 | | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
IEA | -- | | GO:0005543 | phospholipid binding |
IEA | -- |
ARHGEF18 for ontologies About GeneDecksing
Animal Models:
2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Arhgef18):
ARHGEF18 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ARHGEF18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | | | 3 | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) | | | 4 | Regulation of RhoA activity | | | 5 | Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for ARHGEF18
5/13 
Reactome Pathways for ARHGEF18 (see all 13)
ARHGEF18 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGEF18
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/65 Interacting proteins for ARHGEF18 (Q6ZSZ53 ENSP000003529954) via UniProtKB, MINT, STRING, and/or I2D (see all 65)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
ARHGEF18 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGEF18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARHGEF18
3 HMDB Compounds for ARHGEF18 About this table
Search CenterWatch for drugs/clinical trials and news about ARHGEF18 / ARHGI
|
Transcripts
for ARHGEF18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGEF18 gene (2 alternative transcripts): NM_001130955.1 NM_015318.3 Unigene Cluster for ARHGEF18: Rho/Rac guanine nucleotide exchange factor (GEF) 18 Hs.465761 [show with all ESTs]Unigene Representative Sequence: NM_0011309552 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000359920(uc002mgi.3) ENST00000319670(uc002mgh.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF18 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ARHGEF18 (NM_015318) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF18 |
Additional cDNA sequence: AB011093.1 AK074372.1 AK127045.1 AK127453.1 BC008016.1 BC014994.1 BC077721.1 13 DOTS entries: DT.40251226 DT.102824063 DT.212673 DT.99993360 DT.101960565 DT.100774698 DT.121497559 DT.97846677 DT.102824065 DT.121497557 DT.121497578 DT.40269316 DT.100000149 24/175 AceView cDNA sequences (see all 175): BX457177 AI302065 AB011093 BU429720 BQ063546 BU844423 BQ064073 BX457178 BQ425521 AI335866 BE266734 BQ060739 BQ432339 BQ058188 BU685183 BX460193 AI862784 BU854901 BQ945197 BE018691 BU553490 BU846396 AI632373 CK826377
GeneLoc Exon Structure
5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF18 (see all 10) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | · | 12c | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ |
|---|
|
| SP1: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP2: | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 16 | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20a | · | 20b | ^ | 21 | ^ | 22a | · | 22b | ^ | 23a | · | 23b | · | 23c | ^ | 24a | · | 24b | ^ | 25a | · | 25b |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARHGEF18
|
Expression
for ARHGEF18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGEF18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTTAGTCA
About this image
See ARHGEF18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGEF18
SOURCE GeneReport for Unigene cluster: Hs.465761
UniProtKB/Swiss-Prot: ARHGI_HUMAN, Q6ZSZ5Tissue specificity: Expressed in all tissues tested with highest expression in kidney and pancreas. Weakly or notexpressed in liver, skeletal muscle and testis
SABiosciences Custom PCR Arrays for ARHGEF18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF18 |
Orthologs
for ARHGEF18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGEF18 gene from 3/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ARHGEF181 |
rho/rac guanine nucleotide exchange factor (GEF) 18 |
66.05(n)
65.46(a) |
|
420132 XM_418249.3 XP_418249.3 |
zebrafish
(Danio rerio) |
Actinopterygii |
arhgef18b1 |
rho/rac guanine nucleotide exchange factor (GEF) 18b |
60.03(n)
54.85(a) |
|
562264 XM_685658.5 XP_690750.5 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG101886 |
-- |
14(a) |
1 → many |
2L(19502335-19508760) |
ENSEMBL Gene Tree for ARHGEF18 (if available)
TreeFam Gene Tree for ARHGEF18 (if available) |
Paralogs
for ARHGEF18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGEF18 gene
- ARHGEF22 ARHGEF32 ARHGEF122 ARHGEF112 AKAP132 ARHGEF282 NET12 ARHGEF12
4 SIMAP similar genes for ARHGEF18 using alignment to 3 protein entries: ARHGI_HUMAN (see all proteins):ARHGEF28 AKAP13 ARHGEF2 ARHGEF1
ARHGEF18 for paralogs About GeneDecksing
|
Genomic Variants
for ARHGEF18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGEF18 (7459999 - 7537371 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for ARHGEF18
7 CNVs: 78052 89051 89050 8863 73303 73305 73306
3 Indels: 60272 61668 78053 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF18 |
|
Disorders
/ Diseases
for ARHGEF18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGEF18 for disorders About GeneDecksing
1  disease for ARHGEF18: About MalaCardsmucolipidosis
1 disease from the University of Copenhagen DISEASES database for ARHGEF18:Mucolipidosis Human Genome Epidemiology (HuGE) Navigator: ARHGEF18 (1 document)
Export disorders for ARHGEF18 gene to outside databases
|
Publications
for ARHGEF18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGEF18 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with ARHGEF18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A physical and transcript map of the MCOLN1 gene region on human chromosome 19p13.3-p13.2. (PubMed id 11318610)1, 2, 3 Acierno J.S. Jr....Slaugenhaupt S.A. (2001)
- Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9628581)1, 2, 3 Nagase T....Ohara O. (1998)
- G Protein betagamma subunits stimulate p114RhoGEF, a guanine nucleotide exchange factor for RhoA and Rac1: regulation of cell shape and reactive oxygen species production. (PubMed id 14512443)1, 2, 9 Niu J.... Voyno-Yasenetskaya T. (2003)
- Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor. (PubMed id 11085924)1, 2 Blomquist A.... Ruemenapp U. (2000)
- Lulu2 regulates the circumferential actomyosin tensil e system in epithelial cells through p114RhoGEF. (PubMed id 22006950)1 Nakajima H. and Tanoue T. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Spatially restricted activation of RhoA signalling at epithelial junctions by p114RhoGEF drives junction formation and morphogenesis . (PubMed id 21258369)1 Terry S.J....Matter K. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Replication of previous genome-wide association studi es of bone mineral density in premenopausal American women. (PubMed id 20200978)1 Ichikawa S....Econs M.J. (2010)
- The protein network surrounding the human telomere re peat binding factors TRF1, TRF2, and POT1. (PubMed id 20811636)1 Giannone R.J....Liu Y. (2010)
|
External Searches for ARHGEF18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARHGEF18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGEF18 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ARHGEF18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARHGEF18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARHGEF18 gene:
Search GeneIP for patents involving ARHGEF18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ARHGEF18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for ARHGEF18 | | OriGene shRNA RFP for ARHGEF18 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF18 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF18 | | | OriGene Protein Over-expression Lysate for ARHGEF18 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARHGEF18 | | OriGene 3'-UTR Clone for ARHGEF18 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF18 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF18 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARHGEF18 | | OriGene Custom Protein Services for ARHGEF18 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGEF18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF18 |
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 | | | ARHGEF18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF18 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF18 |
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