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Aliases for ARHGEF17 Gene

Aliases for ARHGEF17 Gene

  • Rho Guanine Nucleotide Exchange Factor 17 2 3 5
  • Tumor Endothelial Marker 4 2 3 4
  • Rho-Specific Guanine-Nucleotide Exchange Factor 164 KDa 2 3
  • 164 KDa Rho-Specific Guanine-Nucleotide Exchange Factor 3 4
  • Rho Guanine Nucleotide Exchange Factor (GEF) 17 2 3
  • P164-RhoGEF 3 4
  • P164RHOGEF 3 4
  • TEM4 3 4
  • KIAA0337 4

External Ids for ARHGEF17 Gene

Previous GeneCards Identifiers for ARHGEF17 Gene

  • GC11P073242
  • GC11P072745
  • GC11P072697
  • GC11P073019
  • GC11P069314

Summaries for ARHGEF17 Gene

GeneCards Summary for ARHGEF17 Gene

ARHGEF17 (Rho Guanine Nucleotide Exchange Factor 17) is a Protein Coding gene. Diseases associated with ARHGEF17 include rectum adenocarcinoma. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include actin filament binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF10L.

UniProtKB/Swiss-Prot for ARHGEF17 Gene

  • Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF17 Gene

Genomics for ARHGEF17 Gene

Regulatory Elements for ARHGEF17 Gene

Genomic Location for ARHGEF17 Gene

Chromosome:
11
Start:
73,305,939 bp from pter
End:
73,369,380 bp from pter
Size:
63,442 bases
Orientation:
Plus strand

Genomic View for ARHGEF17 Gene

Genes around ARHGEF17 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF17 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF17 Gene

Proteins for ARHGEF17 Gene

  • Protein details for ARHGEF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PE2-ARHGH_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 17
    Protein Accession:
    Q96PE2
    Secondary Accessions:
    • B2RP20
    • Q86XU2
    • Q8N2S0
    • Q9Y4G3

    Protein attributes for ARHGEF17 Gene

    Size:
    2063 amino acids
    Molecular mass:
    221673 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARHGEF17 Gene

Proteomics data for ARHGEF17 Gene at MOPED

Post-translational modifications for ARHGEF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF17 Gene

Domains & Families for ARHGEF17 Gene

Gene Families for ARHGEF17 Gene

Protein Domains for ARHGEF17 Gene

Suggested Antigen Peptide Sequences for ARHGEF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PE2

UniProtKB/Swiss-Prot:

ARHGH_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
genes like me logo Genes that share domains with ARHGEF17: view

Function for ARHGEF17 Gene

Molecular function for ARHGEF17 Gene

UniProtKB/Swiss-Prot Function:
Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.
genes like me logo Genes that share phenotypes with ARHGEF17: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF17 Gene

Localization for ARHGEF17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF17 Gene COMPARTMENTS Subcellular localization image for ARHGEF17 gene
Compartment Confidence
cytosol 5
nucleus 2
cytoskeleton 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGEF17 Gene

Pathways & Interactions for ARHGEF17 Gene

genes like me logo Genes that share pathways with ARHGEF17: view

Pathways by source for ARHGEF17 Gene

Interacting Proteins for ARHGEF17 Gene

Gene Ontology (GO) - Biological Process for ARHGEF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0030036 actin cytoskeleton organization IDA 12071859
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0097190 apoptotic signaling pathway TAS --
genes like me logo Genes that share ontologies with ARHGEF17: view

No data available for SIGNOR curated interactions for ARHGEF17 Gene

Drugs & Compounds for ARHGEF17 Gene

(3) Drugs for ARHGEF17 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGEF17: view

Transcripts for ARHGEF17 Gene

Unigene Clusters for ARHGEF17 Gene

Rho guanine nucleotide exchange factor (GEF) 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF17 Gene

No ASD Table

Relevant External Links for ARHGEF17 Gene

GeneLoc Exon Structure for
ARHGEF17
ECgene alternative splicing isoforms for
ARHGEF17

Expression for ARHGEF17 Gene

mRNA expression in normal human tissues for ARHGEF17 Gene

Protein differential expression in normal tissues from HIPED for ARHGEF17 Gene

This gene is overexpressed in Fetal Brain (15.6), Retina (10.1), Pancreas (9.1), and Placenta (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGEF17 Gene



SOURCE GeneReport for Unigene cluster for ARHGEF17 Gene Hs.533719

mRNA Expression by UniProt/SwissProt for ARHGEF17 Gene

Q96PE2-ARHGH_HUMAN
Tissue specificity: Highly expressed in the heart.
genes like me logo Genes that share expression patterns with ARHGEF17: view

Protein tissue co-expression partners for ARHGEF17 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARHGEF17 Gene

Orthologs for ARHGEF17 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF17 35
  • 98.49 (n)
  • 97.87 (a)
cow
(Bos Taurus)
Mammalia ARHGEF17 36
  • 90 (a)
OneToOne
ARHGEF17 35
  • 86.38 (n)
  • 85.12 (a)
dog
(Canis familiaris)
Mammalia ARHGEF17 35
  • 88.53 (n)
  • 90.67 (a)
ARHGEF17 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef17 16
Arhgef17 35
  • 84.54 (n)
  • 87.24 (a)
Arhgef17 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF17 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 17 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arhgef17 35
  • 84.32 (n)
  • 86.31 (a)
chicken
(Gallus gallus)
Aves ARHGEF17 35
  • 70.45 (n)
  • 68.98 (a)
ARHGEF17 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF17 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef17 35
  • 71.2 (n)
  • 71.31 (a)
Str.10835 35
zebrafish
(Danio rerio)
Actinopterygii ARHGEF17 (1 of 2) 36
  • 66 (a)
OneToMany
ARHGEF17 (2 of 2) 36
  • 29 (a)
OneToMany
si:ch211-248g20.5 35
  • 69.72 (n)
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43102 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R02F2.2 36
  • 26 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6460 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for ARHGEF17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF17 Gene

ENSEMBL:
Gene Tree for ARHGEF17 (if available)
TreeFam:
Gene Tree for ARHGEF17 (if available)

Paralogs for ARHGEF17 Gene

Paralogs for ARHGEF17 Gene

genes like me logo Genes that share paralogs with ARHGEF17: view

Variants for ARHGEF17 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3741150 - 73,309,987(-) CAAAT(A/C/T)CTCCA intron-variant, nc-transcript-variant, reference, missense
rs2298808 - 73,360,507(+) ACAGG(A/C/G/T)CTTCG nc-transcript-variant, reference, missense
rs473469 -- 73,347,964(+) GCCTC(A/G)GATAG intron-variant
rs569686 -- 73,329,972(-) CAGAT(G/T)GGGAA intron-variant
rs1107038 -- 73,314,926(+) CAGGG(A/G)GTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF17 Gene

Variant ID Type Subtype PubMed ID
nsv832208 CNV Gain 17160897
nsv520665 CNV Loss 19592680
nsv825993 CNV Gain 20364138
nsv897911 CNV Loss 21882294

Variation tolerance for ARHGEF17 Gene

Residual Variation Intolerance Score: 3.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.44; 92.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF17 Gene

HapMap Linkage Disequilibrium report
ARHGEF17
Human Gene Mutation Database (HGMD)
ARHGEF17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF17 Gene

Disorders for ARHGEF17 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGEF17 Gene - From: DISEASES

Disorder Aliases PubMed IDs
rectum adenocarcinoma
  • adenocarcinoma of rectum
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGEF17

Genetic Association Database (GAD)
ARHGEF17
Human Genome Epidemiology (HuGE) Navigator
ARHGEF17
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF17
genes like me logo Genes that share disorders with ARHGEF17: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGEF17 Gene

Publications for ARHGEF17 Gene

  1. A mammalian Rho-specific guanine-nucleotide exchange factor (p164- RhoGEF) without a pleckstrin homology domain. (PMID: 12071859) Ruemenapp U. … Wieland T. (Biochem. J. 2002) 2 3 4 23 67
  2. Cell surface tumor endothelial markers are conserved in mice and humans. (PMID: 11559528) Carson-Walter E.B. … St Croix B. (Cancer Res. 2001) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells. (PMID: 23443559) Fogeron M.L. … Lange B.M. (Nat Commun 2013) 3
  5. RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase II+. (PMID: 23195829) Lutz S. … Wieland T. (Cell. Signal. 2013) 3

Products for ARHGEF17 Gene

Sources for ARHGEF17 Gene

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