Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



ARHGEF17 Gene

protein-coding   GIFtS: 54
GCID: GC11P073019

Rho Guanine Nucleotide Exchange Factor (GEF) 17

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 171 2     p164-RhoGEF2 3
Tumor Endothelial Marker 41 2 3     P164RHOGEF2
Rho-Specific Guanine-Nucleotide Exchange Factor 164 KDa1 2     Rho Guanine Nucleotide Exchange Factor 172
164 KDa Rho-Specific Guanine-Nucleotide Exchange Factor2 3     KIAA03373
TEM42 3     p164RhoGEF3

External Ids:    HGNC: 217261   Entrez Gene: 98282   Ensembl: ENSG000001102377   UniProtKB: Q96PE23   

Export aliases for ARHGEF17 gene to outside databases

Previous GC identifers: GC11P073242 GC11P072745 GC11P072697 GC11P069314


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for ARHGEF17 Gene:
ARHGEF17 (Rho guanine nucleotide exchange factor (GEF) 17) is a protein-coding gene. Diseases associated with ARHGEF17 include endotheliitis, and pulmonary function. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is SPAG9.

UniProtKB/Swiss-Prot: ARHGH_HUMAN, Q96PE2
Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGEF17 gene promoter:
         SRF   NF-1   NF-1/L   Tal-1   SRF (504 AA)   Nkx2-5   E47   SEF-1 (1)   Pax-4a   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF17 promoter sequence
   Search Chromatin IP Primers for ARHGEF17

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF17


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4   Ensembl cytogenetic band:  11q13.4   HGNC cytogenetic band: 11q13.3

ARHGEF17 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF17 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P073019:  view genomic region     (about GC identifiers)

Start:
73,019,334 bp from pter      End:
73,080,425 bp from pter
Size:
61,092 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ARHGH_HUMAN, Q96PE2 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 17  
Size: 2063 amino acids; 221673 Da
Secondary accessions: B2RP20 Q86XU2 Q8N2S0 Q9Y4G3

Explore the universe of human proteins at neXtProt for ARHGEF17: NX_Q96PE2

Explore proteomics data for ARHGEF17 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGEF17 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055601.2  
    ENSEMBL proteins: 
     ENSP00000263674   ENSP00000441135  
    Reactome Protein details: Q96PE2

    ARHGEF17 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for ARHGEF17
    GenScript Custom Purified and Recombinant Proteins Services for ARHGEF17
    Novus Biologicals ARHGEF17 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARHGEF17

    ARHGEF17 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for ARHGEF17
    OriGene Custom Antibody Services for ARHGEF17
    Novus Biologicals ARHGEF17 Antibodies
    Abcam antibodies for ARHGEF17
    Cloud-Clone Corp. Antibodies for ARHGEF17
    ThermoFisher Antibodies for ARHGEF17
    LSBio Antibodies in human, mouse, rat for ARHGEF17

    ARHGEF17 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARHGEF17
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGEF17
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARHGEF17
    Cloud-Clone Corp. CLIAs for ARHGEF17


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    ARHGEF: Rho guanine nucleotide exchange factors

    4 InterPro protein domains:
     IPR000219 DH-domain
     IPR011993 PH_like_dom
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q96PE2

    ProtoNet protein and cluster: Q96PE2

    1 Blocks protein domain: IPB000219 DH domain

    UniProtKB/Swiss-Prot: ARHGH_HUMAN, Q96PE2
    Similarity: Contains 1 DH (DBL-homology) domain


    ARHGEF17 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHGH_HUMAN, Q96PE2
    Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005085guanyl-nucleotide exchange factor activity IDA12071859
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005198structural molecule activity ----
    GO:0005515protein binding ----
         
    ARHGEF17 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF17
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGEF17

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGEF17
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGEF17

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat ARHGEF17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF17 (see all 55):
    hsa-miR-194* hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-328 hsa-miR-429 hsa-miR-25 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF17 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARHGEF17
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF17

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARHGEF17

    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGEF17 (see all 5)
    OriGene ORF clones in mouse, rat for ARHGEF17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARHGEF17 (NM_014786)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF17
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF17

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARHGEF17
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARHGEF17 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF17


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus2
    cytoskeleton1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0015629actin cytoskeleton ----

    ARHGEF17 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for ARHGEF17 About    
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    G alpha (12/13) signalling events0.44
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    4Signaling by FGFR
    Signalling by NGF0.71
    5Regulation of RhoA activity
    Regulation of RhoA activity

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for ARHGEF17
        Regulation of RhoA activity

    3 Reactome Pathways for ARHGEF17
        G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle



    ARHGEF17 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGEF17
    Interactions:

        Search GeneGlobe Interaction Network for ARHGEF17

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGEF17 (Q96PE22, 3 ENSP000002636744) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3974900 I2D: score=2 
    ARHGAP15ENSP000002950954STRING: ENSP00000295095
    ARHGAP44ENSP000003689944STRING: ENSP00000368994
    ROCK2ENSP000003179854STRING: ENSP00000317985
    A2MENSP000003239294STRING: ENSP00000323929
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155cell adhesion ----
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0030036actin cytoskeleton organization IDA12071859
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0043065positive regulation of apoptotic process TAS--

    ARHGEF17 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGEF17 (ARHGH)

    3 HMDB Compounds for ARHGEF17    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for ARHGEF17 gene: 
    NM_014786.3  

    Unigene Clusters for ARHGEF17:

    Rho guanine nucleotide exchange factor (GEF) 17
    Hs.533719  [show with all ESTs], Hs.573929  [show with all ESTs]
    Unigene Representative Sequences: NM_014786, XM_002343116
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000263674(uc001otu.3) ENST00000544519 ENST00000536170 ENST00000537198
    ENST00000536481 ENST00000543530
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat ARHGEF17 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF17 (see all 55):
    hsa-miR-194* hsa-miR-302d hsa-miR-520e hsa-miR-520f hsa-miR-328 hsa-miR-429 hsa-miR-25 hsa-miR-138-2*
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF17 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for ARHGEF17
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF17
    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGEF17 (see all 5)
    OriGene ORF clones in mouse, rat for ARHGEF17
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: ARHGEF17 (NM_014786)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF17
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF17
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF17
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGEF17
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF17
      QuantiFast Probe-based Assays in human, mouse, rat ARHGEF17

    Additional mRNA sequence: 

    AK300095.1 BC050031.1 XM_002343116.2 

    7 DOTS entries:

    DT.316512  DT.91820958  DT.102827517  DT.91670507  DT.97803530  DT.75157547  DT.91731726 

    Selected AceView cDNA sequences (see all 179):

    BM556666 C16956 BM711134 AA317894 NM_014786 BE547763 R74352 BM718893 
    C18195 AI148532 AA236696 BE671432 BM980470 AW966825 AK074500 BI819180 
    BM911726 AI042098 AF378754 AI868009 BP363977 BM545854 AI335837 AW148433 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    ARHGEF17 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACCTCGGA
    ARHGEF17 Expression
    About this image

    ARHGEF17 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGEF17 Protein Expression

    SOURCE GeneReport for Unigene clusters: Hs.533719 Hs.573929

    UniProtKB/Swiss-Prot: ARHGH_HUMAN, Q96PE2
    Tissue specificity: Highly expressed in the heart

        Custom PCR Arrays for ARHGEF17
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF17
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGEF17
    QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF17
    QuantiFast Probe-based Assays in human, mouse, rat ARHGEF17
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF17

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF17 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef171 , 5 Rho guanine nucleotide exchange factor (GEF) 171, 5 84.54(n)1
    87.24(a)1
      7 (54.45 cM)5
    2072121  NM_001081116.11  NP_001074585.11 
     1008697465 
    chicken
    (Gallus gallus)
    Aves ARHGEF171 Rho guanine nucleotide exchange factor (GEF) 17 70.45(n)
    68.98(a)
      777518  XM_003640627.2  XP_003640675.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF176
    Rho guanine nucleotide exchange factor (GEF) 17
    56(a)
    1 ↔ 1
    GL343298.1(19583-268535)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.108352 Transcribed sequence with moderate similarity to protein more 78.76(n)    142021831 
    zebrafish
    (Danio rerio)
    Actinopterygii si:ch211-248g20.51 si:ch211-248g20.5 69.72(n)
    70(a)
      100002227  XM_003200414.2  XP_003200462.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG431026
    --
    23(a)
    1 ↔ 1
    3R(13594157-13620296)
    worm
    (Caenorhabditis elegans)
    Secernentea R02F2.26
    Protein R02F2.2 (R02F2.2) mRNA, complete cds
    26(a)
    1 ↔ 1
    III(5487642-5498952) WBGene00019832


    ENSEMBL Gene Tree for ARHGEF17 (if available)
    TreeFam Gene Tree for ARHGEF17 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for ARHGEF17 gene
    SPAG92  ARHGEF102  ARHGEF10L2  MAPK8IP32  

    ARHGEF17 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for ARHGEF17 (see all 1318)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1419080421,2
    C,F--73022427(+) GTCCCC/TGAGGC 2 P L mis11Minor allele frequency- T:0.00NA 4522
    rs768803581,2
    C--73022486(+) AGCTTC/TGGAGA 2 R W mis10--------
    rs1470859661,2
    F--73022495(+) GAGACG/AAGGGC 2 /K /E mis11Minor allele frequency- A:0.00NA 4536
    rs617587081,2
    C--73022500(+) GAGGGC/TAGTCA 2 G syn10--------
    rs2004613501,2
    --73022519(+) CTGGCA/TGCCTG 2 S C mis10--------
    rs1382879791,2
    C--73022535(+) GGCCCG/AGCCCT 2 /Q /R mis11Minor allele frequency- A:0.00NA 4536
    rs2011032491,2
    --73022542(+) CCCTCC/TTCCAG 2 S syn10--------
    rs2008205441,2
    --73022552(+) GACACA/GTTCGC 2 I V mis10--------
    rs1495811201,2
    C,F--73022615(+) CTTCTG/TTTGGT 2 V F mis11Minor allele frequency- T:0.00NA 4550
    rs1151860091,2
    C,F--73022662(+) ACCCGA/GGCCCA 2 R syn12Minor allele frequency- G:0.01WA NA 4668

    HapMap Linkage Disequilibrium report for ARHGEF17 (73019334 - 73080425 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARHGEF17:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv520665CNV Loss19592680
    nsv897911CNV Loss21882294
    nsv825993CNV Gain20364138
    nsv832208CNV Gain17160897

    Human Gene Mutation Database (HGMD): ARHGEF17
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGEF17
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGEF17

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    4 diseases for ARHGEF17:    
    About MalaCards
    endotheliitis    pulmonary function    spasticity    melanoma


    ARHGEF17 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGEF17
    Human Genome Epidemiology (HuGE) Navigator: ARHGEF17 (1 document)

    Export disorders for ARHGEF17 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for ARHGEF17 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with ARHGEF17)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A mammalian Rho-specific guanine-nucleotide exchange factor (p164- RhoGEF) without a pleckstrin homology domain. (PubMed id 12071859)1, 2, 3, 9 Ruemenapp U....Wieland T. (Biochem. J. 2002)
    2. Cell surface tumor endothelial markers are conserved in mice and humans. (PubMed id 11559528)1, 2, 3 Carson-Walter E.B.... St Croix B. (Cancer Res. 2001)
    3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    4. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (DNA Res. 1997)
    5. RhoGEF17, a Rho-specific guanine nucleotide exchange factor activated by phosphorylation via cyclic GMP-dependent kinase II+. (PubMed id 23195829)1 Lutz S....Wieland T. (Cell. Signal. 2013)
    6. Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. (PubMed id 22911862)1 Mitin N....Der C.J. (PLoS ONE 2012)
    7. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. (PubMed id 23284291)1 Hancock D.B....London S.J. (PLoS Genet. 2012)
    8. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9828 HGNC: 21726 AceView: ARHGEF17 Ensembl:ENSG00000110237 euGenes: HUgn9828
    ECgene: ARHGEF17 H-InvDB: ARHGEF17

    (According to HUGE)
    About This Section

    TryGeneCards Plus
    HUGE: KIAA0337

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for ARHGEF17 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for ARHGEF17 gene:
    Search GeneIP for patents involving ARHGEF17

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for ARHGEF17   OriGene RNAi products in human, mouse, rat for ARHGEF17  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for ARHGEF17  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF17   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for ARHGEF17   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARHGEF17   OriGene Custom Protein Services for ARHGEF17  

     
     
     Block miRNA regulation of human, mouse, rat ARHGEF17 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing ARHGEF17
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF17 Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF17
     QuantiFast Probe-based Assays in human, mouse, rat ARHGEF17 QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF17
     Custom PCR Arrays for ARHGEF17 Search Chromatin IP Primers for ARHGEF17
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGEF17  Search GeneGlobe Interaction Network for ARHGEF17
     Regulatory tfbs in ARHGEF17 promoter
     GenScript Custom Purified and Recombinant Proteins Services for ARHGEF17 GenScript cDNA clones with any tag delivered in your preferred vector for ARHGEF17
     GenScript Custom Assay Services for ARHGEF17 GenScript Custom overexpressing Cell Line Services for ARHGEF17
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for ARHGEF17 (ARHGH)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     ARHGEF17 antibodies
     ARHGEF17 proteins
     Antibodies for ARHGEF17
     See all of Abcam's Antibodies, Kits and Proteins for ARHGEF17
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for ARHGEF17
     Antibodies for ARHGEF17
     ELISAs for ARHGEF17
     CLIAs for ARHGEF17



     Browse ESI BIO Cell Lines and PureStem Progenitors for ARHGEF17
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF17
     SwitchGear 3'UTR luciferase reporter plasmids for ARHGEF17
     SwitchGear Promoter luciferase reporter plasmids for ARHGEF17
     ThermoFisher Antibodies for ARHGEF17
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF17
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF17
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGEF17
     LSBio Antibodies in human, mouse, rat for ARHGEF17
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARHGEF17 gene at Home site.
    Version: 3.12.142 28 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4