ARHGEF17 Gene
protein-coding GIFtS: 52
GCID: GC11P073019
|
|
Rho guanine nucleotide exchange factor (GEF) 17
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Aliases
for ARHGEF17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho Guanine Nucleotide Exchange Factor (GEF) 171 2 | | 164 KDa Rho-Specific Guanine-Nucleotide Exchange Factor2 3 | | TEM41 2 3 | | P164RHOGEF2 | | P164-RhoGEF1 | | Rho Guanine Nucleotide Exchange Factor 172 | | KIAA03371 3 | | Rho-Specific Guanine-Nucleotide Exchange Factor 164 KDa2 | | Tumor Endothelial Marker 42 3 | | P164RhoGEF1 |
Export aliases for ARHGEF17 gene to outside databasesPrevious GC identifers: GC11P073242 GC11P072745 GC11P072697 GC11P069314 |
Summaries
for ARHGEF17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: ARHGH_HUMAN, Q96PE2Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases
|
Genomic Views
for ARHGEF17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGEF17 gene promoter:
SRF NF-1 NF-1/L Tal-1 SRF (504 AA) Nkx2-5 E47 SEF-1 (1) Pax-4a CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGEF17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.3ARHGEF17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P073019: view genomic region
(about GC identifiers)
Start:
|
73,019,334 bp from pter |
End:
|
73,080,425 bp from pter |
Size:
|
61,092 bases |
Orientation:
|
plus strand |
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Proteins
for ARHGEF17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARHGH_HUMAN, Q96PE2 (See
protein sequence)Recommended Name: Rho guanine nucleotide exchange factor 17 Size: 2063 amino acids; 221673 Da
Secondary accessions: B2RP20 Q86XU2 Q8N2S0 Q9Y4G3Explore the universe of human proteins at neXtProt for ARHGEF17: NX_Q96PE2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96PE2
ARHGEF17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055601.2
ENSEMBL proteins: ENSP00000263674 ENSP00000441135 Reactome Protein details: Q96PE2
Human Recombinant Protein Products for ARHGEF17:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
ARHGEF17 for ontologies About GeneDecksing
ARHGEF17 Antibody Products:
Assay Products for ARHGEF17: |
Protein
Domains /
Families
for ARHGEF17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGEF17 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96PE2ProtoNet protein and cluster: Q96PE2 1 Blocks protein family: IPB000219 DH domain
UniProtKB/Swiss-Prot: ARHGH_HUMAN, Q96PE2Similarity: Contains 1 DH (DBL-homology) domain |
Function
for ARHGEF17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ARHGH_HUMAN, Q96PE2Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005085 | guanyl-nucleotide exchange factor activity |
IDA | 12071859 | | GO:0005089 | Rho guanyl-nucleotide exchange factor activity |
IEA | -- |
ARHGEF17 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF17 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: ARHGEF17 (NM_014786) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF17 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF17 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF17 |
|
Pathways & Interactions
for ARHGEF17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | Signaling by GPCR | | | 3 | Regulation of RhoA activity | | | 4 | Signaling by FGFR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
1  BioSystems Pathway for ARHGEF17
5/10 
Reactome Pathways for ARHGEF17 (see all 10)
ARHGEF17 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGEF17
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/49 Interacting proteins for ARHGEF17 (Q96PE22, 3 ENSP000002636744) via UniProtKB, MINT, STRING, and/or I2D (see all 49)About this table
Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006915 | apoptotic process |
TAS | -- | | GO:0007264 | small GTPase mediated signal transduction |
TAS | -- | | GO:0030036 | actin cytoskeleton organization |
IDA | 12071859 | | GO:0035023 | regulation of Rho protein signal transduction |
IEA | -- | | GO:0048011 | nerve growth factor receptor signaling pathway |
TAS | -- |
ARHGEF17 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGEF17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for ARHGEF17
3 HMDB Compounds for ARHGEF17 About this table
Search CenterWatch for drugs/clinical trials and news about ARHGEF17 / ARHGH
|
Transcripts
for ARHGEF17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGEF17 gene: NM_014786.3 Unigene Clusters for ARHGEF17: Rho guanine nucleotide exchange factor (GEF) 17 Hs.533719 [show with all ESTs], Hs.573929 [show with all ESTs]Unigene Representative Sequences: NM_014786, XM_0023431166 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000263674(uc001otu.3) ENST00000544519 ENST00000536170 ENST00000537198
ENST00000536481 ENST00000543530
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF17 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF17
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: ARHGEF17 (NM_014786) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF17 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF17 |
Additional cDNA sequence: AK300095.1 BC050031.1 XM_002343116.2 7 DOTS entries: DT.316512 DT.91820958 DT.102827517 DT.91670507 DT.97803530 DT.75157547 DT.91731726 24/179 AceView cDNA sequences (see all 179): AW148433 BM545854 AI493492 BM559102 AA236696 C18195 AI042098 R74352 AB002335 C16956 AI148532 AA317894 BI819180 AK074500 AW966825 BM911726 BF115084 BM980470 AF378754 AI335837 BP363977 BU177158 BM708538 AI868009
GeneLoc Exon Structure
|
Expression
for ARHGEF17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGEF17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACCTCGGA
About this image
See ARHGEF17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGEF17
SOURCE GeneReport for Unigene clusters: Hs.533719 Hs.573929
UniProtKB/Swiss-Prot: ARHGH_HUMAN, Q96PE2Tissue specificity: Highly expressed in the heart
SABiosciences Custom PCR Arrays for ARHGEF17
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF17
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF17 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF17 |
Orthologs
for ARHGEF17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGEF17 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC7775181 |
rho guanine nucleotide exchange factor 17-like |
78.37(n)
79.42(a) |
|
777518 XM_003640627.1 XP_003640675.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ARHGEF176 |
-- |
50(a) |
1 ↔ 1 |
GL343298.1(19583-268535) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.108352 |
Transcribed sequence with moderate similarity to protein more |
78.76(n) |
|
142021831 |
zebrafish
(Danio rerio) |
Actinopterygii |
si:ch211-248g20.56 |
si:ch211-248g20.5 |
65(a) |
1 ↔ 1 |
18(2187946-2254885) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG431026 |
-- |
17(a) |
1 ↔ 1 |
3R(13594157-13620296) |
worm
(Caenorhabditis elegans) |
Secernentea |
R02F2.26 |
Uncharacterized protein R02F2.2 |
22(a) |
1 ↔ 1 |
III(5487603-5498913) |
ENSEMBL Gene Tree for ARHGEF17 (if available)
TreeFam Gene Tree for ARHGEF17 (if available) |
Paralogs
for ARHGEF17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGEF17 gene
- ECT22 ARHGEF102 SPAG92 ARHGEF10L2 MAPK8IP32
ARHGEF17 for paralogs About GeneDecksing
|
Genomic Variants
for ARHGEF17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGEF17 (73019334 - 73080425 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ARHGEF17
2 CNVs: 75698 85849 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF17 |
|
Disorders
/ Diseases
for ARHGEF17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGEF17 for disorders About GeneDecksing
2  diseases for ARHGEF17: About MalaCardsspasticity melanoma
Human Genome Epidemiology (HuGE) Navigator: ARHGEF17 (1 document)
Export disorders for ARHGEF17 gene to outside databases
|
Publications
for ARHGEF17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGEF17 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with ARHGEF17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A mammalian Rho-specific guanine-nucleotide exchange factor (p164-RhoGEF) without a pleckstrin homology domain. (PubMed id 12071859)1, 2, 3, 9 Rumenapp U....Wieland T. (2002)
- Cell surface tumor endothelial markers are conserved in mice and humans. (PubMed id 11559528)1, 2, 3 Carson-Walter E.B....St Croix B. (2001)
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (1997)
- Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4. (PubMed id 22911862)1 Mitin N....Der C.J. (2012)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1 Takefuji M....Kaibuchi K. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- Identification of ARHGEF17, DENND2D, FGFR3, and RB1 mutations in melanoma by inhibition of nonsense-mediated mRNA decay. (PubMed id 18677770)1 Bloethner S....Hayward N.K. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
|
External Searches for ARHGEF17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARHGEF17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing ARHGEF17 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing ARHGEF17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for ARHGEF17 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for ARHGEF17 gene:
Search GeneIP for patents involving ARHGEF17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for ARHGEF17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
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 | | | ARHGEF17 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF17 |
|  |  |  |  | | | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF17 |
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