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Aliases for ARHGEF17 Gene

Aliases for ARHGEF17 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 17 2 3
  • Tumor Endothelial Marker 4 2 3 4
  • Rho-Specific Guanine-Nucleotide Exchange Factor 164 KDa 2 3
  • 164 KDa Rho-Specific Guanine-Nucleotide Exchange Factor 3 4
  • P164-RhoGEF 3 4
  • P164RHOGEF 3 4
  • TEM4 3 4
  • Rho Guanine Nucleotide Exchange Factor 17 3
  • KIAA0337 4

External Ids for ARHGEF17 Gene

Previous GeneCards Identifiers for ARHGEF17 Gene

  • GC11P073242
  • GC11P072745
  • GC11P072697
  • GC11P073019
  • GC11P069314

Summaries for ARHGEF17 Gene

GeneCards Summary for ARHGEF17 Gene

ARHGEF17 (Rho Guanine Nucleotide Exchange Factor (GEF) 17) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include guanyl-nucleotide exchange factor activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF10L.

UniProtKB/Swiss-Prot for ARHGEF17 Gene

  • Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF17 Gene

Genomics for ARHGEF17 Gene

Regulatory Elements for ARHGEF17 Gene

Genomic Location for ARHGEF17 Gene

Start:
73,306,355 bp from pter
End:
73,369,380 bp from pter
Size:
63,026 bases
Orientation:
Plus strand

Genomic View for ARHGEF17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF17 Gene

Proteins for ARHGEF17 Gene

  • Protein details for ARHGEF17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96PE2-ARHGH_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 17
    Protein Accession:
    Q96PE2
    Secondary Accessions:
    • B2RP20
    • Q86XU2
    • Q8N2S0
    • Q9Y4G3

    Protein attributes for ARHGEF17 Gene

    Size:
    2063 amino acids
    Molecular mass:
    221673 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARHGEF17 Gene

Proteomics data for ARHGEF17 Gene at MOPED

Post-translational modifications for ARHGEF17 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF17 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF17 Gene

Domains for ARHGEF17 Gene

Gene Families for ARHGEF17 Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors

Protein Domains for ARHGEF17 Gene

Suggested Antigen Peptide Sequences for ARHGEF17 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96PE2

UniProtKB/Swiss-Prot:

ARHGH_HUMAN :
  • Q96PE2
Domain:
  • Contains 1 DH (DBL-homology) domain.
genes like me logo Genes that share domains with ARHGEF17: view

Function for ARHGEF17 Gene

Molecular function for ARHGEF17 Gene

UniProtKB/Swiss-Prot Function: Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.

Gene Ontology (GO) - Molecular Function for ARHGEF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity IDA 12071859
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding --
GO:0051015 actin filament binding --
genes like me logo Genes that share ontologies with ARHGEF17: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGEF17 Gene

Localization for ARHGEF17 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF17 Gene COMPARTMENTS Subcellular localization image for ARHGEF17 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARHGEF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGEF17: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF17 Gene

Pathways for ARHGEF17 Gene

genes like me logo Genes that share pathways with ARHGEF17: view

Pathways by source for ARHGEF17 Gene

Interacting Proteins for ARHGEF17 Gene

Gene Ontology (GO) - Biological Process for ARHGEF17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0030036 actin cytoskeleton organization IDA 12071859
GO:0035023 regulation of Rho protein signal transduction --
GO:0043065 positive regulation of apoptotic process TAS --
genes like me logo Genes that share ontologies with ARHGEF17: view

Compounds for ARHGEF17 Gene

(3) HMDB Compounds for ARHGEF17 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ARHGEF17: view

Transcripts for ARHGEF17 Gene

Unigene Clusters for ARHGEF17 Gene

Rho guanine nucleotide exchange factor (GEF) 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF17 Gene

No ASD Table

Relevant External Links for ARHGEF17 Gene

GeneLoc Exon Structure for
ARHGEF17
ECgene alternative splicing isoforms for
ARHGEF17

Expression for ARHGEF17 Gene

mRNA expression in normal human tissues for ARHGEF17 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGEF17 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF17 Gene Hs.533719

mRNA Expression by UniProt/SwissProt for ARHGEF17 Gene

Q96PE2-ARHGH_HUMAN
Tissue specificity: Highly expressed in the heart.
genes like me logo Genes that share expressions with ARHGEF17: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARHGEF17 Gene

Orthologs for ARHGEF17 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF17 35
  • 98.49 (n)
  • 97.87 (a)
cow
(Bos Taurus)
Mammalia ARHGEF17 35
  • 86.38 (n)
  • 85.12 (a)
ARHGEF17 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF17 35
  • 88.53 (n)
  • 90.67 (a)
ARHGEF17 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef17 35
  • 84.54 (n)
  • 87.24 (a)
Arhgef17 16
Arhgef17 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF17 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 17 (a)
OneToMany
-- 36
  • 68 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Arhgef17 35
  • 84.32 (n)
  • 86.31 (a)
chicken
(Gallus gallus)
Aves ARHGEF17 35
  • 70.45 (n)
  • 68.98 (a)
ARHGEF17 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF17 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef17 35
  • 71.2 (n)
  • 71.31 (a)
Str.10835 35
zebrafish
(Danio rerio)
Actinopterygii ARHGEF17 (1 of 2) 36
  • 66 (a)
OneToMany
ARHGEF17 (2 of 2) 36
  • 29 (a)
OneToMany
si:ch211-248g20.5 35
  • 69.72 (n)
  • 70 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG43102 36
  • 23 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R02F2.2 36
  • 26 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6460 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for ARHGEF17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF17 Gene

ENSEMBL:
Gene Tree for ARHGEF17 (if available)
TreeFam:
Gene Tree for ARHGEF17 (if available)

Paralogs for ARHGEF17 Gene

Paralogs for ARHGEF17 Gene

genes like me logo Genes that share paralogs with ARHGEF17: view

Variants for ARHGEF17 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF17 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs473469 -- 73,347,964(+) GCCTC(A/G)GATAG intron-variant
rs483887 -- 73,367,353(-) AATTT(C/G)CCAAG intron-variant
rs569686 -- 73,329,972(-) CAGAT(G/T)GGGAA intron-variant
rs572469 -- 73,343,864(+) GTGCA(A/G)TGATG intron-variant
rs625572 -- 73,333,198(+) GTTTT(A/G)AAGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF17 Gene

Variant ID Type Subtype PubMed ID
nsv832208 CNV Gain 17160897
nsv520665 CNV Loss 19592680
nsv825993 CNV Gain 20364138
nsv897911 CNV Loss 21882294

Relevant External Links for ARHGEF17 Gene

HapMap Linkage Disequilibrium report
ARHGEF17
Human Gene Mutation Database (HGMD)
ARHGEF17

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF17 Gene

Disorders for ARHGEF17 Gene

Relevant External Links for ARHGEF17

Genetic Association Database (GAD)
ARHGEF17
Human Genome Epidemiology (HuGE) Navigator
ARHGEF17
genes like me logo Genes that share disorders with ARHGEF17: view

No data available for UniProtKB/Swiss-Prot for ARHGEF17 Gene

Publications for ARHGEF17 Gene

  1. A mammalian Rho-specific guanine-nucleotide exchange factor (p164- RhoGEF) without a pleckstrin homology domain. (PMID: 12071859) Ruemenapp U. … Wieland T. (Biochem. J. 2002) 2 3 4 23
  2. Cell surface tumor endothelial markers are conserved in mice and humans. (PMID: 11559528) Carson-Walter E.B. … St Croix B. (Cancer Res. 2001) 2 3 4
  3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 48
  4. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  5. Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture. (PMID: 16896804) Mohl M. … Lutz S. (Naunyn Schmiedebergs Arch. Pharmacol. 2006) 23

Products for ARHGEF17 Gene

  • antibodies-online peptides for ARHGEF17
  • antibodies-online antibodies for ARHGEF17
  • antibodies-online kits for ARHGEF17

Sources for ARHGEF17 Gene

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