Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGEF16 Gene

protein-coding   GIFtS: 55
GCID: GC01P003394

Rho guanine nucleotide exchange factor (GEF) 16
 Explore 6 diseases affiliated with
ARHGEF16 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARHGEF16    

Aliases
for ARHGEF16 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 161 2     Rho Guanine Exchange Factor (GEF) 162
NBR1 2 3     Rho Guanine Nucleotide Exchange Factor 162
GEF161 2     EPHEXIN43
Ephexin-43     Ephexin-43

External Ids:    HGNC: 155151   Entrez Gene: 272372   Ensembl: ENSG000001307627   UniProtKB: Q5VV413   

Export aliases for ARHGEF16 gene to outside databases

Previous GC identifers: GC01P002818 GC01P003328 GC01P002945 GC01P003154 GC01P003163 GC01P002663


Summaries
for ARHGEF16 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARHGEF16:
Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and
protein-lipid interactions. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: ARHGG_HUMAN, Q5VV41
Function: Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP.
May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42
and mediate activation of CDC42 by the viral protein HPV16 E6




Genomic Views
for ARHGEF16 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004350.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGEF16 gene promoter:
         AP-2beta   AP-2gamma   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARHGEF16 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGEF16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.3

ARHGEF16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF16 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P003394:  view genomic region     (about GC identifiers)

Start:
 3,370,990 bp from pter      End:
 3,397,677 bp from pter
Size:
 26,688 bases      Orientation:
 plus strand

Proteins
for ARHGEF16 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: ARHGG_HUMAN, Q5VV41 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 16  
Size: 709 amino acids; 80105 Da
Subunit: Interacts with ELMO2, EPHA2, RAC1 and RHOG; mediates activation of RAC1 by EPHA2. Interacts with TAX1BP3 (via
PDZ domain). May interact with CDC42; stimulated by HPV16 E6
Subcellular location: Cytoplasm (Probable)
Sequence caution: Sequence=AAH02681.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for ARHGEF16:
1X6B (3D)    
Secondary accessions: Q86TF0 Q99434
Alternative splicing: 2 isoforms:  Q5VV41-1   Q5VV41-2   

Explore the universe of human proteins at neXtProt for ARHGEF16: NX_Q5VV41

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5VV41

    • ARHGEF16 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_055263.2  
    ENSEMBL proteins: 
     ENSP00000367629   ENSP00000367624   ENSP00000367622   ENSP00000411936   ENSP00000390853  
     ENSP00000408887  
    Reactome Protein details: Q5VV41
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for ARHGEF16 
    GenScript Custom Purified and Recombinant Proteins Services for ARHGEF16
    Novus Biologicals ARHGEF16 Protein
    Novus Biologicals ARHGEF16 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for ARHGEF16

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--


    ARHGEF16 for ontologies           About GeneDecksing



    ARHGEF16 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARHGEF16 
    GenScript Custom Superior Antibodies Services for ARHGEF16
    Novus Biologicals ARHGEF16 Antibodies
    Abcam antibodies for ARHGEF16 
    Uscn Antibodies for ARHGEF16
    Search ThermoFisher Antibodies for ARHGEF16

    Assay Products for ARHGEF16: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGEF16
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for ARHGEF16

    Protein Domains /
    Families
    for ARHGEF16 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARHGEF16 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q5VV41

    ProtoNet protein and cluster: Q5VV41

    1 Blocks protein family: IPB000219 DH domain

    UniProtKB/Swiss-Prot: ARHGG_HUMAN, Q5VV41
    Domain: The PDZ-binding motif mediates interaction with TAX1BP3
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SH3 domain


    Function
    for ARHGEF16 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: ARHGG_HUMAN, Q5VV41
    Function: Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP.
    May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42
    and mediate activation of CDC42 by the viral protein HPV16 E6
    Induction: Up-regulated by HPV16 E6 (at protein level)

    miRNA
    Products:            		 OriGene 3'-UTR Clone: ARHGEF16
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGEF16
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ARHGEF16
    SwitchGear 3'UTR luciferase reporter plasmid: ARHGEF16 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF16 (see all 4)
    OriGene shRNA RFP: ARHGEF16
    OriGene siRNA: ARHGEF16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF16

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for ARHGEF16

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF16 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF16 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARHGEF16 (NM_014448)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF16 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for ARHGEF16
    Search LifeMap BioReagents cell lines for ARHGEF16

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF16

    Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IDA--
    GO:0005515protein binding IPI--
    GO:0005543phospholipid binding IEA--
    GO:0017048Rho GTPase binding IPI--
    GO:0030165PDZ domain binding IPI--


    ARHGEF16 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for ARHGEF16:
     Decreased focal adhesion (FA)   Upregulation of Wnt/beta-caten 


    Pathways & Interactions
    for ARHGEF16 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/16 super-pathways (see all 16) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell death signalling via NRAGE, NRIF and NADE
    		Cell death signalling via NRAGE, NRIF and NADE1.00
    		G alpha (12/13) signalling events0.39
    		NRAGE signals death through JNK0.74
    		Rho GTPase cycle0.25
    		p75 NTR receptor-mediated signalling0.73
    		Signaling by Rho GTPases0.25
    2GPCR Pathway
    		GPCR Pathway1.00
    		Breast Cancer Regulation by Stathmin10.58
    		Ras Pathway0.62
    		Pancreatic Adenocarcinoma0.55
    3Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    		GPCR downstream signaling0.89
    4Rho Family GTPases
    		Rho Family GTPases1.00
    		Molecular Mechanisms of Cancer0.51
    5G-AlphaQ Signaling
    		G-AlphaQ Signaling1.00
    		G-AlphaI Signaling0.47

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGEF16 (see all 19)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling

    5/10        Reactome Pathways for ARHGEF16 (see all 10)
        GPCR downstream signaling
    Signaling by Rho GTPases
    G alpha (12/13) signalling events
    Cell death signalling via NRAGE, NRIF and NADE
    Signaling by GPCR



    ARHGEF16 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGEF16

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for ARHGEF16 (Q5VV412, 3 ENSP000003676294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3974919 I2D: score=2 
    YWHAZP631042, 3MINT-3295696 I2D: score=1 
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS--
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0032863activation of Rac GTPase activity IMP--
    GO:0032864activation of Cdc42 GTPase activity IDA--
    GO:0035023regulation of Rho protein signal transduction ----


    ARHGEF16 for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARHGEF16 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGEF16
    Search CenterWatch for drugs/clinical trials and news about ARHGEF16 / ARHGG 

    Transcripts
    for ARHGEF16 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARHGEF16 gene: 
    NM_014448.3  

    Unigene Cluster for ARHGEF16:

    Rho guanine nucleotide exchange factor (GEF) 16
    Hs.87435  [show with all ESTs]
    Unigene Representative Sequence: NM_014448
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378378(uc001akg.4) ENST00000378373(uc001aki.3 uc010nzh.2)
    ENST00000378371(uc001akj.3) ENST00000445297 ENST00000464620(uc009vli.1)
    ENST00000418137 ENST00000485984 ENST00000413250

    miRNA
    Products:             		 OriGene 3'-UTR Clone: ARHGEF16
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGEF16
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate ARHGEF16
    SwitchGear 3'UTR luciferase reporter plasmid: ARHGEF16 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF16 (see all 4)
    OriGene shRNA RFP: ARHGEF16
    OriGene siRNA: ARHGEF16
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF16
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF16 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF16 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: ARHGEF16 (NM_014448)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF16
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF16 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF16
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF16
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF16
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF16

    Additional cDNA sequence: 

    AK091910.1 AK095984.1 AK296150.1 AK310408.1 BC002681.1 BC051838.1 BT007270.1 D89016.1 

    6 DOTS entries:

    DT.112722  DT.100781826  DT.99968963  DT.95333246  DT.121399975  DT.75102322 

    24/93 AceView cDNA sequences (see all 93):

    CR609468 AI581104 AL513948 BF222883 BF002075 BQ218186 AI739406 BX348349 
    BM743014 BM790507 BX350450 AK091910 AI492124 BM742773 BM758474 BU684697 
    BE619024 CB988090 CF457324 BE515190 AA593891 NM_014448 BM784124 AW139450 

    GeneLoc Exon Structure


    Expression
    for ARHGEF16 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGEF16 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GTTCCCTGGG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARHGEF16 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARHGEF16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGEF16

    SOURCE GeneReport for Unigene cluster: Hs.87435
        SABiosciences Custom PCR Arrays for ARHGEF16
    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF16
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF16
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF16
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF16
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF16

    Orthologs
    for ARHGEF16 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF16 gene from 6/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves ARHGEF161 Rho guanine nucleotide exchange factor (GEF) 16 68.75(n)
    62.4(a)    		   419386  XM_417549.3  XP_417549.3 
    lizard
    (Anolis carolinensis)    		 Reptilia ARHGEF166
    		 --
    		 58(a)
    		 1 ↔ 1
    		 GL343629.1(64839-79434)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.161532 Transcribed sequence with weak similarity to protein more 76.06(n)    BX710026.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5671801 novel protein similar to vertebrate Rho guanine exchange more 61.07(n)
    55.76(a)    		   567180  NM_001123283.1  NP_001116755.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta BcDNA:GH036933   -- 33(a)     --
    worm
    (Caenorhabditis elegans)    		 Secernentea K07D4.7a3   -- 39(a)
    (best of 2)    		   II(4004982-4015768)   --


    ENSEMBL Gene Tree for ARHGEF16 (if available)
    TreeFam Gene Tree for ARHGEF16 (if available) 

    Paralogs
    for ARHGEF16 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGEF16 gene
    ARHGEF192  ARHGEF152  NGEF2  ARHGEF262  ARHGEF52  
    11 SIMAP similar genes for ARHGEF16 using alignment to 5 protein entries:     ARHGG_HUMAN (see all proteins):
    ARHGEF26    NGEF    DKFZp686N1969    ARHGEF19    ARHGEF5    ARHGEF15
    LOC728377    ITSN2    ITSN1    PLEKHG5    ARHGEF37

    ARHGEF16 for paralogs           About GeneDecksing



    Genomic Variants
    for ARHGEF16 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/594 NCBI SNPs in ARHGEF16 are shown (see all 594)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1835481651,2
    		--3369157(+) AGAGCA/GCTGCC 1 -- us2k10--------
    rs740484961,2
    		C,--3369242(+) GGAAGG/ACCCCC 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1384193151,2
    		--3369258(+) AGGCTA/GAGCCA 1 -- us2k10--------
    rs1866874171,2
    		--3369308(+) CGGGCC/TGACCC 1 -- us2k10--------
    rs601628781,2
    		C,--3369388(+) AGCTGG/ATTCCT 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs353110861,2
    		C,F--3369408(+) TCCCTT/GAGGCC 1 -- us2k13Minor allele frequency- G:0.33NA 6
    rs1444250291,2
    		--3369466(+) CAGAGC/GTGACA 1 -- us2k10--------
    rs1394395771,2
    		--3369539(+) CACACA/GCTGAG 1 -- us2k10--------
    rs340377741,2
    		C,F,--3369553(+) CCTCTG/-GAAGC 1 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs24876691,2
    		F,--3369583(-) GGTCTG/AGCTTC 1 -- us2k1 tfbs32Minor allele frequency- A:0.11NA EA 240

    HapMap Linkage Disequilibrium report for ARHGEF16 (3370990 - 3397677 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for ARHGEF16
         5 CNVs: 29825 4196 34820 3278 29824

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF16
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGEF16

    Disorders / Diseases
    for ARHGEF16 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARHGEF16 for disorders           About GeneDecksing

    6 diseases for ARHGEF16:    About MalaCards
    frontal sinusitis    sinusitis    spasticity    breast cancer
    adenocarcinoma    pancreatitis

    Human Genome Epidemiology (HuGE) Navigator: ARHGEF16 (1 document)

    Export disorders for ARHGEF16 gene to outside databases

    Publications
    for ARHGEF16 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGEF16 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with ARHGEF16)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42. (PubMed id 21139582)1, 2 Oliver A.W....Hampson I.N. (2011)
    2. Ephexin4 and EphA2 mediate cell migration through a R hoG-dependent mechanism. (PubMed id 20679435)1, 2 Hiramoto-Yamaki N....Katoh H. (2010)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
    6. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    7. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1 Takefuji M....Kaibuchi K. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    External Searches for ARHGEF16 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ARHGEF16 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27237 HGNC: 15515 AceView: ARHGEF16 Ensembl:ENSG00000130762 euGenes: HUgn27237
    ECgene: ARHGEF16 H-InvDB: ARHGEF16

    Other Databases showing ARHGEF16 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARHGEF16 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGEF16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARHGEF16 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for ARHGEF16 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARHGEF16 gene:
    Search GeneIP for patents involving ARHGEF16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for ARHGEF16 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for ARHGEF16  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF16   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF16  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for ARHGEF16   OriGene 3'-UTR Clone for ARHGEF16  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF16   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF16  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARHGEF16   OriGene Custom Protein Services for ARHGEF16  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGEF16
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF16
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF16
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF16
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF16
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF16
     GenScript Custom Purified and Recombinant Proteins Services for ARHGEF16 GenScript cDNA clones with any tag delivered in your preferred vector for ARHGEF16
     GenScript Custom Assay Services for ARHGEF16 GenScript Custom Superior Antibodies Services for ARHGEF16
     GenScript Custom overexpressing Cell Line Services for ARHGEF16 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARHGEF16 promoter
     Search Chromatin IP Primers for ARHGEF16
     RT2 qPCR Primer Assay in human, mouse, rat ARHGEF16
     Search GNC Networks for ARHGEF16
     SABiosciences PCR Arrays including human, mouse, rat ARHGEF16
     Search Tocris compounds for ARHGEF16
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARHGEF16 antibodies
     ARHGEF16 proteins
     ARHGEF16 lysates
     Antibodies for ARHGEF16
     See all of Abcam's Antibodies, Kits and Proteins for ARHGEF16
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     ARHGEF16 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for ARHGEF16
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF16
     SwitchGear 3'UTR luciferase reporter plasmids for ARHGEF16
     SwitchGear Promoter luciferase reporter plasmids for ARHGEF16
     Search ThermoFisher Antibodies for ARHGEF16
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF16
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      ARHGEF16 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 100 solr: 1.4