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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGEF16 Gene

protein-coding   GIFtS: 57
GCID: GC01P003394

Rho Guanine Nucleotide Exchange Factor (GEF) 16

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 161 2     Rho Guanine Exchange Factor (GEF) 162
NBR2 3     Rho Guanine Nucleotide Exchange Factor 162
Putative Neuroblastoma Protein1     EPHEXIN43
GEF162     Ephexin-43
ephexin-42     

External Ids:    HGNC: 155151   Entrez Gene: 272372   Ensembl: ENSG000001307627   UniProtKB: Q5VV413   

Export aliases for ARHGEF16 gene to outside databases

Previous GC identifers: GC01P002818 GC01P003328 GC01P002945 GC01P003154 GC01P003163 GC01P002663


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGEF16 Gene:
Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein
and protein-lipid interactions. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARHGEF16 Gene: 
ARHGEF16 (Rho guanine nucleotide exchange factor (GEF) 16) is a protein-coding gene. Diseases associated with ARHGEF16 include frontal sinusitis, and sinusitis, and among its related super-pathways are NRAGE signals death through JNK and Ras Pathway. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.

UniProtKB/Swiss-Prot: ARHGG_HUMAN, Q5VV41
Function: Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for
GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also
activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004350.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGEF16 gene promoter:
         AP-2beta   AP-2gamma   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF16 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGEF16

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF16


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.3   Ensembl cytogenetic band:  1p36.32   HGNC cytogenetic band: 1p36.3

ARHGEF16 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF16 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P003394:  view genomic region     (about GC identifiers)

Start:
3,370,990 bp from pter      End:
3,397,677 bp from pter
Size:
26,688 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARHGG_HUMAN, Q5VV41 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 16  
Size: 709 amino acids; 80105 Da
Subunit: Interacts with ELMO2, EPHA2, RAC1 and RHOG; mediates activation of RAC1 by EPHA2. Interacts with TAX1BP3
(via PDZ domain). May interact with CDC42; stimulated by HPV16 E6
Subcellular location: Cytoplasm (Probable)
Sequence caution: Sequence=AAH02681.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
1 PDB 3D structure from and Proteopedia for ARHGEF16:
1X6B (3D)    
Secondary accessions: Q86TF0 Q99434
Alternative splicing: 2 isoforms:  Q5VV41-1   Q5VV41-2   

Explore the universe of human proteins at neXtProt for ARHGEF16: NX_Q5VV41

Explore proteomics data for ARHGEF16 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5VV41

  • ARHGEF16 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGEF16 Protein Expression
    REFSEQ proteins: NP_055263.2  
    ENSEMBL proteins: 
     ENSP00000367629   ENSP00000367624   ENSP00000367622   ENSP00000411936   ENSP00000390853  
     ENSP00000408887  
    Reactome Protein details: Q5VV41
    Human Recombinant Protein Products for ARHGEF16: 
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    Browse Sino Biological Cell Lysates 
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    Cloud-Clone Corp. Proteins for ARHGEF16 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005829cytosol TAS--

    ARHGEF16 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    PLEKH: Pleckstrin homology (PH) domain containing
    ARHGEF: Rho guanine nucleotide exchange factors

    4 InterPro protein domains:
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR001452 SH3_domain
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q5VV41

    ProtoNet protein and cluster: Q5VV41

    1 Blocks protein domain: IPB000219 DH domain

    UniProtKB/Swiss-Prot: ARHGG_HUMAN, Q5VV41
    Domain: The PDZ-binding motif mediates interaction with TAX1BP3
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 SH3 domain


    ARHGEF16 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHGG_HUMAN, Q5VV41
    Function: Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for
    GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also
    activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6
    Induction: Up-regulated by HPV16 E6 (at protein level)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IDA--
    GO:0005515protein binding IPI--
    GO:0005543phospholipid binding IEA--
    GO:0017048Rho GTPase binding IPI--
    GO:0030165PDZ domain binding IPI--
         
    ARHGEF16 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGEF16:
     Decreased focal adhesion (FA)   Upregulation of Wnt/beta-caten 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGEF16 
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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGEF16 About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell death signalling via NRAGE, NRIF and NADE
    Cell death signalling via NRAGE, NRIF and NADE0.74
    p75 NTR receptor-mediated signalling0.73
    NRAGE signals death through JNK0.74
    G alpha (12/13) signalling events0.46
    2GPCR Pathway
    Ras Pathway0.73
    Pancreatic Adenocarcinoma0.59
    GPCR Pathway0.62
    Breast Cancer Regulation by Stathmin10.58
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    5Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGEF16 (see all 19)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling

    5/10        Reactome Pathways for ARHGEF16 (see all 10)
        GPCR downstream signaling
    Signaling by Rho GTPases
    G alpha (12/13) signalling events
    Cell death signalling via NRAGE, NRIF and NADE
    Signaling by GPCR



    ARHGEF16 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGEF16

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for ARHGEF16 (Q5VV412, 3 ENSP000003676294) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SFNP319472, 3MINT-3974919 I2D: score=2 
    YWHAZP631042, 3MINT-3295696 I2D: score=1 
    YWHAGP619813, ENSP000003063304I2D: score=1 STRING: ENSP00000306330
    YWHAQP273483, ENSP000002380814I2D: score=1 STRING: ENSP00000238081
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0032863activation of Rac GTPase activity IMP--
    GO:0032864activation of Cdc42 GTPase activity IDA--
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0043065positive regulation of apoptotic process TAS--

    ARHGEF16 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGEF16 (ARHGG)

    Search CenterWatch for drugs/clinical trials and news about ARHGEF16 / ARHGG

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGEF16 gene: 
    NM_014448.3  

    Unigene Cluster for ARHGEF16:

    Rho guanine nucleotide exchange factor (GEF) 16
    Hs.87435  [show with all ESTs]
    Unigene Representative Sequence: NM_014448
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000378378(uc001akg.4) ENST00000378373(uc001aki.3 uc010nzh.2)
    ENST00000378371(uc001akj.3) ENST00000445297 ENST00000464620(uc009vli.1)
    ENST00000418137 ENST00000485984 ENST00000413250
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AK091910.1 AK095984.1 AK296150.1 AK310408.1 BC002681.1 BC051838.1 BT007270.1 D89016.1 

    6 DOTS entries:

    DT.112722  DT.100781826  DT.99968963  DT.95333246  DT.121399975  DT.75102322 

    24/93 AceView cDNA sequences (see all 93):

    AI581104 CR609468 BM791150 BE515190 CN480782 BC051838 BT007270 BM784124 
    BX348349 BM743014 AA577044 BX479263 BX350450 BU740803 BU684697 BM818554 
    BM790507 BM727250 CF457324 AI492124 AA593891 AI739406 BQ218186 BC002681 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGEF16 expression in normal human tissues (normalized intensities)      ARHGEF16 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTCCCTGGG
    ARHGEF16 Expression
    About this image


    ARHGEF16 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 2 entries
             Muscle Progenitor Cells Mandibular Arch Muscles
     
     Ectoderm (Gastrulation Derivatives)
             Ectoderm
     
     Placenta (Extraembryonic Tissues)
             Chorion Frondosum
     
     Neural Tube (Nervous System)
             Prosencephalon
     
     Stomach (Gastrointestinal Tract)

    See ARHGEF16 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGEF16

    SOURCE GeneReport for Unigene cluster: Hs.87435
        SABiosciences Custom PCR Arrays for ARHGEF16
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF16

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF16 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef161 , 5 Rho guanine nucleotide exchange factor (GEF) 161, 5 80.82(n)1
    81.66(a)1
      4 (83.96 cM)5
    2309721  NM_001112744.11  NP_001106215.11 
     1542784865 
    chicken
    (Gallus gallus)
    Aves ARHGEF161 Rho guanine nucleotide exchange factor (GEF) 16 68.75(n)
    62.4(a)
      419386  XM_417549.3  XP_417549.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF166
    Uncharacterized protein
    59(a)
    1 ↔ 1
    GL343629.1(64839-79434)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.161532 Transcribed sequence with weak similarity to protein more 76.06(n)    BX710026.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5671801 novel protein similar to vertebrate Rho guanine exchange more 61.07(n)
    55.76(a)
      567180  NM_001123283.1  NP_001116755.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta BcDNA:GH036933   -- 33(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea K07D4.7a3   -- 39(a)
    (best of 2)
      II(4004982-4015768)   --


    ENSEMBL Gene Tree for ARHGEF16 (if available)
    TreeFam Gene Tree for ARHGEF16 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGEF16 gene
    ARHGEF192  ARHGEF152  NGEF2  ARHGEF52  ARHGEF262  
    11 SIMAP similar genes for ARHGEF16 using alignment to 5 protein entries:     ARHGG_HUMAN (see all proteins):
    ARHGEF26    NGEF    DKFZp686N1969    ARHGEF19    ARHGEF5    ARHGEF15
    LOC728377    ITSN2    ITSN1    PLEKHG5    ARHGEF37

    ARHGEF16 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/772 SNPs in ARHGEF16 are shown (see all 772)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1835481651,2
    --3369157(+) AGAGCA/GCTGCC 1 -- us2k10--------
    rs740484961,2
    C,F--3369242(+) GGAAGG/ACCCCC 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs1384193151,2
    --3369258(+) AGGCTA/GAGCCA 1 -- us2k10--------
    rs1866874171,2
    --3369308(+) CGGGCC/TGACCC 1 -- us2k10--------
    rs601628781,2
    C,F--3369388(+) AGCTGG/ATTCCT 1 -- us2k12Minor allele frequency- A:0.07WA 120
    rs353110861,2
    C,F--3369408(+) TCCCTT/GAGGCC 1 -- us2k13Minor allele frequency- G:0.33NA 6
    rs1444250291,2
    --3369466(+) CAGAGC/GTGACA 1 -- us2k10--------
    rs1394395771,2
    C--3369539(+) CACACA/GCTGAG 1 -- us2k10--------
    rs340377741,2
    C,F--3369553(+) CCTCTG/-GAAGC 1 -- us2k12Minor allele frequency- -:0.50NA CSA 4
    rs24876691,2
    C,F--3369583(-) GGTCTG/AGCTTC 1 -- us2k1 tfbs32Minor allele frequency- A:0.11NA EA 240

    HapMap Linkage Disequilibrium report for ARHGEF16 (3370990 - 3397677 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/21 variations for ARHGEF16 (see all 21):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1571906CNV Deletion17803354
    esv2727362CNV Deletion23290073
    esv2727251CNV Deletion23290073
    esv2727139CNV Deletion23290073
    nsv299CNV Insertion18451855
    dgv103n71CNV Loss21882294
    dgv97n71CNV Loss21882294
    nsv871243CNV Loss21882294
    dgv104n71CNV Loss21882294
    dgv95n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    7 diseases for ARHGEF16:    About MalaCards
    frontal sinusitis    sinusitis    spasticity    neuroblastoma
    adenocarcinoma    pancreatitis    breast cancer


    ARHGEF16 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGEF16
    Human Genome Epidemiology (HuGE) Navigator: ARHGEF16 (1 document)

    Export disorders for ARHGEF16 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGEF16 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with ARHGEF16)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42. (PubMed id 21139582)1, 2 Oliver A.W....Hampson I.N. (2011)
    2. Ephexin4 and EphA2 mediate cell migration through a R hoG-dependent mechanism. (PubMed id 20679435)1, 2 Hiramoto-Yamaki N....Katoh H. (2010)
    3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (2010)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Genome-wide association of lipid-lowering response to statins in combined study populations. (PubMed id 20339536)1 Barber M.J....Krauss R.M. (2010)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 27237 HGNC: 15515 AceView: ARHGEF16 Ensembl:ENSG00000130762 euGenes: HUgn27237
    ECgene: ARHGEF16 H-InvDB: ARHGEF16

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGEF16 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARHGEF16 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGEF16 gene:
    Search GeneIP for patents involving ARHGEF16

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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