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Aliases for ARHGEF16 Gene

Aliases for ARHGEF16 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 16 2 3
  • Ephexin-4 3 4
  • NBR 3 4
  • Rho Guanine Nucleotide Exchange Factor 16 3
  • Rho Guanine Exchange Factor (GEF) 16 3
  • Putative Neuroblastoma Protein 2
  • EPHEXIN4 4
  • GEF16 3

External Ids for ARHGEF16 Gene

Summaries for ARHGEF16 Gene

Entrez Gene Summary for ARHGEF16 Gene

  • Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF16 Gene

ARHGEF16 (Rho Guanine Nucleotide Exchange Factor (GEF) 16) is a Protein Coding gene. Diseases associated with ARHGEF16 include neuroblastoma. Among its related pathways are Signaling by FGFR and RhoGDI Pathway. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.

UniProtKB/Swiss-Prot for ARHGEF16 Gene

  • Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF16 Gene

Genomics for ARHGEF16 Gene

Genomic Location for ARHGEF16 Gene

Start:
3,454,426 bp from pter
End:
3,481,113 bp from pter
Size:
26,688 bases
Orientation:
Plus strand

Genomic View for ARHGEF16 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF16 Gene

Regulatory Elements for ARHGEF16 Gene

Proteins for ARHGEF16 Gene

  • Protein details for ARHGEF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VV41-ARHGG_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 16
    Protein Accession:
    Q5VV41
    Secondary Accessions:
    • Q86TF0
    • Q99434

    Protein attributes for ARHGEF16 Gene

    Size:
    709 amino acids
    Molecular mass:
    80105 Da
    Quaternary structure:
    • Interacts with ELMO2, EPHA2, RAC1 and RHOG; mediates activation of RAC1 by EPHA2. Interacts with TAX1BP3 (via PDZ domain). May interact with CDC42; stimulated by HPV16 E6.
    SequenceCaution:
    • Sequence=AAH02681.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGEF16 Gene

    Alternative splice isoforms for ARHGEF16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF16 Gene

Proteomics data for ARHGEF16 Gene at MOPED

Post-translational modifications for ARHGEF16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF16 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF16 Gene

Domains for ARHGEF16 Gene

Gene Families for ARHGEF16 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • ARHGEF :Rho guanine nucleotide exchange factors

Protein Domains for ARHGEF16 Gene

UniProtKB/Swiss-Prot:

ARHGG_HUMAN
Domain:
  • The PDZ-binding motif mediates interaction with TAX1BP3:
    • Q5VV41
  • Contains 1 DH (DBL-homology) domain.:
    • Q5VV41
  • Contains 1 PH domain.:
    • Q5VV41
  • Contains 1 SH3 domain.:
    • Q5VV41
genes like me logo Genes that share domains with ARHGEF16: view

Function for ARHGEF16 Gene

Molecular function for ARHGEF16 Gene

UniProtKB/Swiss-Prot Function: Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.
UniProtKB/Swiss-Prot Induction: Up-regulated by HPV16 E6 (at protein level).

Gene Ontology (GO) - Molecular Function for ARHGEF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IDA 20679435
GO:0005515 protein binding IPI 20679435
GO:0017048 Rho GTPase binding IPI 20679435
GO:0030165 PDZ domain binding IPI 21139582
GO:0030971 receptor tyrosine kinase binding IPI 20679435
genes like me logo Genes that share ontologies with ARHGEF16: view

Phenotypes for ARHGEF16 Gene

genes like me logo Genes that share phenotypes with ARHGEF16: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGEF16 Gene

Localization for ARHGEF16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF16 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF16 Gene COMPARTMENTS Subcellular localization image for ARHGEF16 gene
Compartment Confidence
cytosol 4
nucleus 3

Gene Ontology (GO) - Cellular Components for ARHGEF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGEF16: view

Pathways for ARHGEF16 Gene

genes like me logo Genes that share pathways with ARHGEF16: view

Gene Ontology (GO) - Biological Process for ARHGEF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0035023 regulation of Rho protein signal transduction --
GO:0043065 positive regulation of apoptotic process TAS --
GO:0048011 neurotrophin TRK receptor signaling pathway TAS --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGEF16: view

Transcripts for ARHGEF16 Gene

Unigene Clusters for ARHGEF16 Gene

Rho guanine nucleotide exchange factor (GEF) 16:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF16 Gene

No ASD Table

Relevant External Links for ARHGEF16 Gene

GeneLoc Exon Structure for
ARHGEF16
ECgene alternative splicing isoforms for
ARHGEF16

Expression for ARHGEF16 Gene

mRNA expression in normal human tissues for ARHGEF16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF16 Gene

This gene is overexpressed in Colon - Transverse (6.4) and Kidney - Cortex (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGEF16 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF16 Gene Hs.87435

genes like me logo Genes that share expressions with ARHGEF16: view

Orthologs for ARHGEF16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF16 36
  • 98.03 (n)
  • 97.28 (a)
ARHGEF16 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGEF16 36
  • 86.24 (n)
  • 86.41 (a)
ARHGEF16 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF16 36
  • 84.18 (n)
  • 81.78 (a)
ARHGEF16 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef16 36
  • 80.96 (n)
  • 81.38 (a)
Arhgef16 16
Arhgef16 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF16 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF16 37
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef16 36
  • 80.91 (n)
  • 82.18 (a)
chicken
(Gallus gallus)
Aves ARHGEF16 36
  • 69.57 (n)
  • 63.23 (a)
ARHGEF16 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF16 37
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16153 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5334 36
zebrafish
(Danio rerio)
Actinopterygii arhgef16 36
  • 61.51 (n)
  • 56.46 (a)
arhgef16 37
  • 52 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Exn 37
  • 10 (a)
OneToMany
BcDNA:GH03693 38
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea ephx-1 37
  • 20 (a)
OneToMany
tag-218 36
  • 49.28 (n)
  • 41.95 (a)
K07D4.7b 38
  • 39 (a)
K07D4.7a 38
  • 39 (a)
Species with no ortholog for ARHGEF16:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF16 Gene

ENSEMBL:
Gene Tree for ARHGEF16 (if available)
TreeFam:
Gene Tree for ARHGEF16 (if available)

Paralogs for ARHGEF16 Gene

Paralogs for ARHGEF16 Gene

Selected SIMAP similar genes for ARHGEF16 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGEF16: view

Variants for ARHGEF16 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF16 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs881978 -- 3,480,045(-) TTTGA(A/G)GAAGC intron-variant
rs947351 -- 3,466,474(-) CCCAG(C/T)ACACA intron-variant
rs947352 -- 3,458,617(-) ATGGC(A/G)GGAGG intron-variant
rs1051515 -- 3,480,891(+) AGGGG(A/G)CAACT utr-variant-3-prime
rs1051517 -- 3,481,000(+) GGGCC(C/T)TGAGT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF16 Gene

Variant ID Type Subtype PubMed ID
nsv871581 CNV Loss 21882294
nsv830092 CNV Gain+Loss 17160897
dgv95n71 CNV Loss 21882294
dgv96n71 CNV Loss 21882294
dgv97n71 CNV Loss 21882294
nsv470687 CNV Loss 18288195
dgv12e1 CNV Complex 17122850
dgv99n71 CNV Loss 21882294
dgv101n71 CNV Loss 21882294
dgv102n71 CNV Loss 21882294
nsv871243 CNV Loss 21882294
nsv871334 CNV Gain+Loss 21882294
dgv103n71 CNV Loss 21882294
nsv830203 CNV Loss 17160897
dgv104n71 CNV Loss 21882294
dgv105n71 CNV Loss 21882294
esv2727139 CNV Deletion 23290073
esv1571906 CNV Deletion 17803354
esv2727251 CNV Deletion 23290073
esv2727362 CNV Deletion 23290073
nsv299 CNV Insertion 18451855

Relevant External Links for ARHGEF16 Gene

HapMap Linkage Disequilibrium report
ARHGEF16

Disorders for ARHGEF16 Gene

(1) MalaCards Diseases for ARHGEF16 Gene

Search for ARHGEF16 Gene in MalaCards »

Relevant External Links for ARHGEF16

Genetic Association Database (GAD)
ARHGEF16
Human Genome Epidemiology (HuGE) Navigator
ARHGEF16
genes like me logo Genes that share disorders with ARHGEF16: view

No data available for UniProtKB/Swiss-Prot for ARHGEF16 Gene

Publications for ARHGEF16 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  3. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. (PMID: 20679435) Hiramoto-Yamaki N. … Katoh H. (J. Cell Biol. 2010) 3 4
  4. The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42. (PMID: 21139582) Oliver A.W. … Hampson I.N. (Br. J. Cancer 2011) 3 4
  5. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 49

Products for ARHGEF16 Gene

  • antibodies-online proteins for ARHGEF16
  • antibodies-online antibodies for ARHGEF16
  • antibodies-online kits for ARHGEF16

Sources for ARHGEF16 Gene

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