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Aliases for ARHGEF16 Gene

Aliases for ARHGEF16 Gene

  • Rho Guanine Nucleotide Exchange Factor 16 2 3 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 16 2 3
  • Ephexin-4 3 4
  • NBR 3 4
  • Rho Guanine Exchange Factor (GEF) 16 3
  • Putative Neuroblastoma Protein 2
  • EPHEXIN4 4
  • GEF16 3

External Ids for ARHGEF16 Gene

Previous GeneCards Identifiers for ARHGEF16 Gene

  • GC01P002818
  • GC01P003328
  • GC01P002945
  • GC01P003154
  • GC01P003163
  • GC01P003394
  • GC01P002663
  • GC01P003370

Summaries for ARHGEF16 Gene

Entrez Gene Summary for ARHGEF16 Gene

  • Although the specific function of this protein is not known yet, it is thought to be involved in protein-protein and protein-lipid interactions. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF16 Gene

ARHGEF16 (Rho Guanine Nucleotide Exchange Factor 16) is a Protein Coding gene. Diseases associated with ARHGEF16 include Frontal Sinusitis. Among its related pathways are Signaling by GPCR and GPCR Pathway. GO annotations related to this gene include PDZ domain binding and receptor tyrosine kinase binding. An important paralog of this gene is ARHGEF26.

UniProtKB/Swiss-Prot for ARHGEF16 Gene

  • Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF16 Gene

Genomics for ARHGEF16 Gene

Regulatory Elements for ARHGEF16 Gene

Enhancers for ARHGEF16 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F003453 1.5 FANTOM5 Ensembl ENCODE 21.7 +3.2 3207 8.8 PKNOX1 MLX ZFP64 ARID4B DMAP1 YBX1 SLC30A9 ZNF143 FOS ZNF263 ARHGEF16 TP73-AS1 GC01M003454 ENSG00000272088
GH01F003470 1.2 Ensembl ENCODE 18.1 +17.9 17871 3.4 MLX ARID4B DMAP1 ZNF48 ZNF263 SP5 REST PPARG KAT8 GLIS1 ARHGEF16 MEGF6 ENSG00000272088 GC01M003454
GH01F003479 0.9 Ensembl ENCODE 17.2 +27.0 26980 4.4 GTF2F1 CTCF MXI1 JUN MAX ZIC2 RARA YY1 CTBP1 POLR2A ARHGEF16 MEGF6 ENSG00000238260 TPRG1L TP73 WRAP73 ENSG00000272088 GC01M003454
GH01F003483 1.3 Ensembl ENCODE 13.8 +29.6 29575 0.4 CTCF TEAD4 INSM2 ZNF2 RAD21 ZBTB48 POLR2A HSF1 SMC3 KLF7 ARHGEF16 MEGF6 ENSG00000238260 TPRG1L TP73 WRAP73 ENSG00000272088 GC01M003454
GH01F003441 0.2 ENCODE 8.2 -12.8 -12795 0.2 SOX13 SOX5 MAFK ARHGEF16 GC01M003410
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARHGEF16 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGEF16 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000162789 474 1001 ATF1 MLX ARID4B GLI4 YBX1 ZNF48 ZNF121 SLC30A9 GLIS2 ZNF143

Genomic Location for ARHGEF16 Gene

Chromosome:
1
Start:
3,454,426 bp from pter
End:
3,481,115 bp from pter
Size:
26,690 bases
Orientation:
Plus strand

Genomic View for ARHGEF16 Gene

Genes around ARHGEF16 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF16 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF16 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF16 Gene

Proteins for ARHGEF16 Gene

  • Protein details for ARHGEF16 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VV41-ARHGG_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 16
    Protein Accession:
    Q5VV41
    Secondary Accessions:
    • Q86TF0
    • Q99434

    Protein attributes for ARHGEF16 Gene

    Size:
    709 amino acids
    Molecular mass:
    80105 Da
    Quaternary structure:
    • Interacts with ELMO2, EPHA2, RAC1 and RHOG; mediates activation of RAC1 by EPHA2. Interacts with TAX1BP3 (via PDZ domain). May interact with CDC42; stimulated by HPV16 E6.
    SequenceCaution:
    • Sequence=AAH02681.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGEF16 Gene

    Alternative splice isoforms for ARHGEF16 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF16 Gene

Post-translational modifications for ARHGEF16 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF16 Gene

No data available for DME Specific Peptides for ARHGEF16 Gene

Domains & Families for ARHGEF16 Gene

Protein Domains for ARHGEF16 Gene

Suggested Antigen Peptide Sequences for ARHGEF16 Gene

Graphical View of Domain Structure for InterPro Entry

Q5VV41

UniProtKB/Swiss-Prot:

ARHGG_HUMAN :
  • The PDZ-binding motif mediates interaction with TAX1BP3.
Domain:
  • The PDZ-binding motif mediates interaction with TAX1BP3.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PH domain.
  • Contains 1 SH3 domain.
genes like me logo Genes that share domains with ARHGEF16: view

Function for ARHGEF16 Gene

Molecular function for ARHGEF16 Gene

UniProtKB/Swiss-Prot Function:
Guanyl-nucleotide exchange factor of the RHOG GTPase stimulating the exchange of RHOG-associated GDP for GTP. May play a role in chemotactic cell migration by mediating the activation of RAC1 by EPHA2. May also activate CDC42 and mediate activation of CDC42 by the viral protein HPV16 E6.
UniProtKB/Swiss-Prot Induction:
Up-regulated by HPV16 E6 (at protein level).

Gene Ontology (GO) - Molecular Function for ARHGEF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005515 protein binding IPI 20679435
GO:0017048 Rho GTPase binding IPI 20679435
GO:0030165 PDZ domain binding IPI 21139582
genes like me logo Genes that share ontologies with ARHGEF16: view
genes like me logo Genes that share phenotypes with ARHGEF16: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGEF16 Gene

Localization for ARHGEF16 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF16 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF16 Gene COMPARTMENTS Subcellular localization image for ARHGEF16 gene
Compartment Confidence
cytosol 5
nucleus 3
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for ARHGEF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005913 cell-cell adherens junction IDA 25468996
genes like me logo Genes that share ontologies with ARHGEF16: view

Pathways & Interactions for ARHGEF16 Gene

genes like me logo Genes that share pathways with ARHGEF16: view

Gene Ontology (GO) - Biological Process for ARHGEF16 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043065 positive regulation of apoptotic process TAS --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
GO:0060326 cell chemotaxis IMP 20679435
genes like me logo Genes that share ontologies with ARHGEF16: view

No data available for SIGNOR curated interactions for ARHGEF16 Gene

Transcripts for ARHGEF16 Gene

Unigene Clusters for ARHGEF16 Gene

Rho guanine nucleotide exchange factor (GEF) 16:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF16 Gene

No ASD Table

Relevant External Links for ARHGEF16 Gene

GeneLoc Exon Structure for
ARHGEF16
ECgene alternative splicing isoforms for
ARHGEF16

Expression for ARHGEF16 Gene

mRNA expression in normal human tissues for ARHGEF16 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF16 Gene

This gene is overexpressed in Colon - Transverse (x6.4) and Kidney - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for ARHGEF16 Gene

This gene is overexpressed in Stomach (18.9), Colon (18.4), and Pancreas (9.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGEF16 Gene



NURSA nuclear receptor signaling pathways regulating expression of ARHGEF16 Gene:

ARHGEF16

SOURCE GeneReport for Unigene cluster for ARHGEF16 Gene:

Hs.87435
genes like me logo Genes that share expression patterns with ARHGEF16: view

Primer Products

No data available for Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for ARHGEF16 Gene

Orthologs for ARHGEF16 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF16 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF16 34 35
  • 98.03 (n)
cow
(Bos Taurus)
Mammalia ARHGEF16 34 35
  • 86.24 (n)
dog
(Canis familiaris)
Mammalia ARHGEF16 34 35
  • 84.18 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF16 35
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef16 34 16 35
  • 80.96 (n)
rat
(Rattus norvegicus)
Mammalia Arhgef16 34
  • 80.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF16 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGEF16 34 35
  • 69.57 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGEF16 35
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.16153 34
zebrafish
(Danio rerio)
Actinopterygii arhgef16 34 35
  • 61.51 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5334 34
fruit fly
(Drosophila melanogaster)
Insecta BcDNA:GH03693 36
  • 33 (a)
Exn 35
  • 10 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea tag-218 34
  • 49.28 (n)
K07D4.7a 36
  • 39 (a)
K07D4.7b 36
  • 39 (a)
ephx-1 35
  • 20 (a)
OneToMany
Species where no ortholog for ARHGEF16 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF16 Gene

ENSEMBL:
Gene Tree for ARHGEF16 (if available)
TreeFam:
Gene Tree for ARHGEF16 (if available)

Paralogs for ARHGEF16 Gene

Paralogs for ARHGEF16 Gene

genes like me logo Genes that share paralogs with ARHGEF16: view

Variants for ARHGEF16 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF16 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1051515 -- 3,480,891(+) AGGGG(A/G)CAACT nc-transcript-variant, utr-variant-3-prime
rs1051517 -- 3,481,000(+) GGGCC(C/T)TGAGT nc-transcript-variant, utr-variant-3-prime
rs10797394 -- 3,477,303(+) TCCCC(A/G)TCACC intron-variant
rs10797395 -- 3,478,475(+) CAGGT(A/G)GAGAA nc-transcript-variant, reference, synonymous-codon
rs10797396 -- 3,481,361(+) GCTGC(A/G)CCTTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF16 Gene

Variant ID Type Subtype PubMed ID
esv1571906 CNV deletion 17803354
esv2758915 CNV gain 17122850
esv3355688 CNV duplication 20981092
esv3449417 CNV duplication 20981092
esv3563426 CNV deletion 23714750
esv3893545 CNV loss 25118596
nsv1012423 CNV gain 25217958
nsv299 CNV insertion 18451855
nsv470687 CNV loss 18288195
nsv475972 CNV novel sequence insertion 20440878
nsv476024 CNV novel sequence insertion 20440878
nsv545124 CNV loss 21841781
nsv830092 CNV gain+loss 17160897
nsv830203 CNV loss 17160897
nsv951959 CNV deletion 24416366

Variation tolerance for ARHGEF16 Gene

Residual Variation Intolerance Score: 85.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.90; 59.25% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF16 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF16

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF16 Gene

Disorders for ARHGEF16 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGEF16 Gene - From: DISEASES

Disorder Aliases PubMed IDs
frontal sinusitis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for ARHGEF16

Genetic Association Database (GAD)
ARHGEF16
Human Genome Epidemiology (HuGE) Navigator
ARHGEF16
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF16
genes like me logo Genes that share disorders with ARHGEF16: view

No data available for UniProtKB/Swiss-Prot and Genatlas for ARHGEF16 Gene

Publications for ARHGEF16 Gene

  1. The HPV16 E6 binding protein Tip-1 interacts with ARHGEF16, which activates Cdc42. (PMID: 21139582) Oliver A.W. … Hampson I.N. (Br. J. Cancer 2011) 3 4 64
  2. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 46 64
  3. Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. (PMID: 20679435) Hiramoto-Yamaki N. … Katoh H. (J. Cell Biol. 2010) 3 4 64
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ARHGEF16 Gene

Sources for ARHGEF16 Gene

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