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ARHGEF15 Gene

protein-coding   GIFtS: 55
GCID: GC17P008213

Rho Guanine Nucleotide Exchange Factor (GEF) 15

  Search for ARHGEF15
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 151 2     Rho Guanine Exchange Factor (GEF) 151
E52 3     Ephexin52
Vsm-RhoGEF2 3     ephexin-52
ARGEF152 5     Rho Guanine Nucleotide Exchange Factor 152
KIAA09153 5     Ephexin-53

External Ids:    HGNC: 155901   Entrez Gene: 228992   Ensembl: ENSG000001988447   OMIM: 6085045   UniProtKB: O949893   

Export aliases for ARHGEF15 gene to outside databases

Previous GC identifers: GC17P008591 GC17P009307 GC17P008156 GC17P008414 GC17P008154 GC17P008108


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGEF15 Gene:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli
that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine
nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two
alternatively spliced transcripts variants that encode the same protein have been found for this gene. (provided
by RefSeq, Aug 2010)

GeneCards Summary for ARHGEF15 Gene:
ARHGEF15 (Rho guanine nucleotide exchange factor (GEF) 15) is a protein-coding gene. GO annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.

UniProtKB/Swiss-Prot: ARHGF_HUMAN, O94989
Function: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle
contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity
of EPHB2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010718.17  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGEF15 gene promoter:
         C/EBPbeta   RP58   SREBP-1c   NF-kappaB   SREBP-1b   SREBP-1a   Chx10   c-Jun   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF15 promoter sequence
   Search Chromatin IP Primers for ARHGEF15

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

ARHGEF15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF15 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P008213:  view genomic region     (about GC identifiers)

Start:
8,213,556 bp from pter      End:
8,225,834 bp from pter
Size:
12,279 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARHGF_HUMAN, O94989 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 15  
Size: 841 amino acids; 91940 Da
Subunit: Interacts with EPHB2 (By similarity). Interacts with EPHA4
Sequence caution: Sequence=BAA74938.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K6G1 Q8N449 Q9H8B4

Explore the universe of human proteins at neXtProt for ARHGEF15: NX_O94989

Explore proteomics data for ARHGEF15 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-353 triggers
    UBE3A-mediated ubiquitination (By similarity)1
  • Ubiquitinated; UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse
    formation (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGEF15 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_079290.1  NP_776089.2  

    ENSEMBL proteins: 
     ENSP00000462796   ENSP00000355026   ENSP00000464540   ENSP00000463875   ENSP00000412505  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGEF: Rho guanine nucleotide exchange factors

    1 InterPro protein domain:
     IPR000219 DH-domain

    Graphical View of Domain Structure for InterPro Entry O94989

    ProtoNet protein and cluster: O94989

    1 Blocks protein domain: IPB000219 DH domain

    UniProtKB/Swiss-Prot: ARHGF_HUMAN, O94989
    Similarity: Contains 1 DH (DBL-homology) domain


    Find genes that share domains with ARHGEF15           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHGF_HUMAN, O94989
    Function: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle
    contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity
    of EPHB2

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity ISS--
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI12775584
         
    Find genes that share ontologies with ARHGEF15           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Arhgef15):
     cardiovascular system  nervous system  tumorigenesis  vision/eye 

    Find genes that share phenotypes with ARHGEF15           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arhgef15tm1(KOMP)Vlcg for ARHGEF15

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF15
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    hsa-miR-485-5p hsa-miR-193a-3p hsa-miR-136 hsa-miR-4288 hsa-let-7d hsa-miR-3660 hsa-miR-632 hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF15 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF15


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARHGF_HUMAN, O94989: Cell projection, dendrite (By similarity). Note=Expressed exclusively in dendrites of the
    developing hippocampus (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030425dendrite ISS--

    Find genes that share ontologies with ARHGEF15           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGEF15 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Pancreatic Adenocarcinoma0.59
    GPCR Pathway0.62
    Breast Cancer Regulation by Stathmin10.58
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    3G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    4fMLP Pathway
    CXCR4 Pathway0.39
    Internalin Pathway0.31
    5TGF-Beta Pathway
    MAPK Family Pathway0.60

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGEF15 (see all 19)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling

    2 BioSystems Pathways for ARHGEF15
        EPHA forward signaling
    Regulation of RhoA activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGEF15
    Interactions:

        GeneGlobe Interaction Network for ARHGEF15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for ARHGEF15 (O949892, 3 ENSP000003550264) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MOB4Q9Y3A32, 3, ENSP000003157024MINT-66097 I2D: score=5 STRING: ENSP00000315702
    UBE3AQ050863, ENSP000003810454I2D: score=1 STRING: ENSP00000381045
    EPHA4P547643, ENSP000002818214I2D: score=2 STRING: ENSP00000281821
    C11orf49Q9H6J73, ENSP000003678784I2D: score=5 STRING: ENSP00000367878
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032319regulation of Rho GTPase activity ISS--
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0050790regulation of catalytic activity IDA12775584
    GO:0061299retina vasculature morphogenesis in camera-type eye IEA--
    GO:2000297negative regulation of synapse maturation ISS--

    Find genes that share ontologies with ARHGEF15           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGEF15 (ARHGF)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGEF15 gene (2 alternative transcripts): 
    NM_025014.1  NM_173728.3  

    Unigene Cluster for ARHGEF15:

    Rho guanine nucleotide exchange factor (GEF) 15
    Hs.443109  [show with all ESTs]
    Unigene Representative Sequence: BC036749
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583529 ENST00000455564(uc002glb.2) ENST00000361926(uc002glc.3 uc002gld.3 uc010vuw.2)
    ENST00000579439 ENST00000581809 ENST00000578286 ENST00000582060 ENST00000421050

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    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF15 (see all 24):
    hsa-miR-485-5p hsa-miR-193a-3p hsa-miR-136 hsa-miR-4288 hsa-let-7d hsa-miR-3660 hsa-miR-632 hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF15 3' UTR sequence
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      QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF15
      QuantiFast Probe-based Assays in human, mouse, rat ARHGEF15

    Additional mRNA sequence: 

    AB020722.1 AK291626.1 AK300327.1 BC036749.1 

    5 DOTS entries:

    DT.441535  DT.120926831  DT.120926830  DT.97804904  DT.120926822 

    Selected AceView cDNA sequences (see all 79):

    NM_173728 BM849066 CA439135 BM701263 W21162 AB020722 BC036749 CK823093 
    AA707157 BQ787423 BQ004849 BM973464 BQ100782 BQ101069 AK023853 CB265566 
    AA909488 AW003155 BQ877184 BE504684 BM706860 BV201502 AI825125 AW005121 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF15    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:        -                                   -     -     -                                                                           
    SP2:                                                                                                                                    
    SP3:        -                                                                                                                           
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for ARHGEF15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGEF15 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATTGGAGA
    ARHGEF15 Expression
    About this image


    ARHGEF15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Adipose (Muscoskeletal System)
             Interscapular Brown Adipose Depot
    ARHGEF15 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGEF15 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443109

    UniProtKB/Swiss-Prot: ARHGF_HUMAN, O94989
    Tissue specificity: Expressed in the vascular smooth muscle of coronary artery

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF15 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef151 , 5 Rho guanine nucleotide exchange factor (GEF) 151, 5 84.33(n)1
    85.48(a)1
      11 (42.21 cM)5
    4428011  NM_177566.31  NP_808234.21 
     689431575 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF156
    Rho guanine nucleotide exchange factor (GEF) 15
    38(a)
    1 ↔ 1
    GL343466.1(36161-52635)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BQ523609.12   -- 82.69(n)    BQ523609.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgef156
    ARHGEF15 (2 of 2)6
    Rho guanine nucleotide exchange factor (GEF) 15
    42(a)
    29(a)
    1 ↔ many
    1 ↔ many
    5(63299498-63332021) ENSDARG00000059742
    12(23716578-23756618) ENSDARG00000061844
    fruit fly
    (Drosophila melanogaster)
    Insecta Exn6
    Ephexin
    12(a)
    1 → many
    3L(16963113-16987488)
    worm
    (Caenorhabditis elegans)
    Secernentea ephx-16
    Protein EPHX-1, isoform a
    16(a)
    1 → many
    II(4004889-4016077) WBGene00019487


    ENSEMBL Gene Tree for ARHGEF15 (if available)
    TreeFam Gene Tree for ARHGEF15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGEF15 gene
    ARHGEF192  ARHGEF162  NGEF2  ARHGEF52  ARHGEF262  
    4 SIMAP similar genes for ARHGEF15 using alignment to 5 protein entries:     ARHGF_HUMAN (see all proteins):
    ARHGEF19    ARHGEF16    LOC728377    NGEF

    Find genes that share paralogs with ARHGEF15           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGEF15 (see all 413)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887217911,2
    --8211669(+) CCCTGC/TCTCTA 1 -- us2k10--------
    rs1929718911,2
    C--8211734(+) TATTCA/GGGAGA 1 -- us2k10--------
    rs1842690111,2
    C--8211796(+) AGATCA/C/GCACCA 1 -- us2k10--------
    rs745614991,2
    C--8211835(+) GACTCC/TGTCTC 1 -- us2k10--------
    rs1433126211,2
    --8211891(+) GTTTTC/TATTGG 1 -- us2k10--------
    rs1887429451,2
    --8212025(+) GCACGA/GTCTCA 1 -- us2k10--------
    rs1118558121,2
    C--8212106(+) CAGGCA/GAGTGC 1 -- us2k10--------
    rs1836572541,2
    --8212275(+) GTGCCC/TGCCAC 2 -- us2k10--------
    rs1115997451,2
    C,F--8212276(+) TGCCCG/ACCACC 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1475238191,2
    --8212325(+) GATGGA/GGTTTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGEF15 (8213556 - 8225834 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ARHGEF15:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv527633CNV Loss19592680
    nsv1967CNV Loss18451855
    nsv833353CNV Loss17160897
    nsv907661CNV Gain21882294
    nsv457664CNV Gain19166990
    nsv470576CNV Gain18288195

    Human Gene Mutation Database (HGMD): ARHGEF15
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGEF15
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGEF15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608504    OMIM disorders: --


    Find genes that share disorders with ARHGEF15           About GenesLikeMe

    Genetic Association Database (GAD): ARHGEF15
    Human Genome Epidemiology (HuGE) Navigator: ARHGEF15 (1 document)

    Export disorders for ARHGEF15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGEF15 gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ARHGEF15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1998)
    2. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. (PubMed id 12775584)1, 2, 9 Ogita H.... Mochizuki N. (Circ. Res. 2003)
    3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells. (PubMed id 23029280)1 Kusuhara S....Uemura A. (PLoS ONE 2012)
    8. EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. (PubMed id 21029865)1 Margolis S.S....Greenberg M.E. (Cell 2010)
    9. Ephecting excitatory synapse development. (PubMed id 21029857)1 Dalva M.B. (Cell 2010)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 22899 HGNC: 15590 AceView: ARHGEF15 Ensembl:ENSG00000198844 euGenes: HUgn22899
    ECgene: ARHGEF15 H-InvDB: ARHGEF15

    (According to HUGE)
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    HUGE: KIAA0915

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGEF15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGEF15 gene:
    Search GeneIP for patents involving ARHGEF15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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