Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGEF15 Gene

protein-coding   GIFtS: 54
GCID: GC17P008213

Rho Guanine Nucleotide Exchange Factor (GEF) 15

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 151 2     Ephexin52
Rho Guanine Exchange Factor (GEF) 151 2     ephexin-52
E52 3     Rho GEF 152
Vsm-RhoGEF2 3     Rho Guanine Nucleotide Exchange Factor 152
ARGEF152 5     Ephexin-53
KIAA09153 5     

External Ids:    HGNC: 155901   Entrez Gene: 228992   Ensembl: ENSG000001988447   OMIM: 6085045   UniProtKB: O949893   

Export aliases for ARHGEF15 gene to outside databases

Previous GC identifers: GC17P008591 GC17P009307 GC17P008156 GC17P008414 GC17P008154 GC17P008108


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGEF15 Gene:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli
that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine
nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two
alternatively spliced transcripts variants that encode the same protein have been found for this gene. (provided
by RefSeq, Aug 2010)

GeneCards Summary for ARHGEF15 Gene: 
ARHGEF15 (Rho guanine nucleotide exchange factor (GEF) 15) is a protein-coding gene. Diseases associated with ARHGEF15 include spasticity, and adenocarcinoma, and among its related super-pathways are Ras Pathway and Rho Family GTPases. GO annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.

UniProtKB/Swiss-Prot: ARHGF_HUMAN, O94989
Function: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle
contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity
of EPHB2




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010718.16  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGEF15 gene promoter:
         C/EBPbeta   RP58   SREBP-1c   NF-kappaB   SREBP-1b   SREBP-1a   Chx10   c-Jun   Pax-4a   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF15 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGEF15

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF15


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17p13.1   Ensembl cytogenetic band:  17p13.1   HGNC cytogenetic band: 17p13.1

ARHGEF15 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF15 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P008213:  view genomic region     (about GC identifiers)

Start:
8,213,556 bp from pter      End:
8,225,834 bp from pter
Size:
12,279 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARHGF_HUMAN, O94989 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 15  
Size: 841 amino acids; 91940 Da
Subunit: Interacts with EPHB2 (By similarity). Interacts with EPHA4
Subcellular location: Cell projection, dendrite (By similarity). Note=Expressed exclusively in dendrites of the
developing hippocampus (By similarity)
Sequence caution: Sequence=BAA74938.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K6G1 Q8N449 Q9H8B4

Explore the universe of human proteins at neXtProt for ARHGEF15: NX_O94989

Explore proteomics data for ARHGEF15 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-353 triggers
    UBE3A-mediated ubiquitination (By similarity)
  • UniProtKB: Ubiquitinated; UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse
    formation (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O94989

  • ARHGEF15 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGEF15 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_079290.1  NP_776089.2  

    ENSEMBL proteins: 
     ENSP00000462796   ENSP00000355026   ENSP00000464540   ENSP00000463875   ENSP00000412505  

    Human Recombinant Protein Products for ARHGEF15: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for ARHGEF15
    OriGene Protein Over-expression Lysate for ARHGEF15
    OriGene MassSpec for ARHGEF15 
    OriGene Custom Protein Services for ARHGEF15
    GenScript Custom Purified and Recombinant Proteins Services for ARHGEF15
    Novus Biologicals ARHGEF15 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for ARHGEF15 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0030425dendrite ISS--

    ARHGEF15 for ontologies           About GeneDecksing



    ARHGEF15 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for ARHGEF15
    GenScript Custom Superior Antibodies Services for ARHGEF15
    Novus Biologicals ARHGEF15 Antibodies
    Abcam antibodies for ARHGEF15
    Cloud-Clone Corp. Antibodies for ARHGEF15 
    Search ThermoFisher Antibodies for ARHGEF15
    LSBio Antibodies in human, mouse, rat for ARHGEF15 

    Assay Products for ARHGEF15: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARHGEF15
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGEF15
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for ARHGEF15 
    Cloud-Clone Corp. CLIAs for ARHGEF15


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGEF: Rho guanine nucleotide exchange factors

    1 InterPro protein domain:
     IPR000219 DH-domain

    Graphical View of Domain Structure for InterPro Entry O94989

    ProtoNet protein and cluster: O94989

    1 Blocks protein domain: IPB000219 DH domain

    UniProtKB/Swiss-Prot: ARHGF_HUMAN, O94989
    Similarity: Contains 1 DH (DBL-homology) domain


    ARHGEF15 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHGF_HUMAN, O94989
    Function: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle
    contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity
    of EPHB2

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity ISS--
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI12775584
         
    ARHGEF15 for ontologies           About GeneDecksing


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Arhgef15):
     cardiovascular system  nervous system  tumorigenesis  vision/eye 

    ARHGEF15 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arhgef15tm1(KOMP)Vlcg for ARHGEF15

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGEF15 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARHGEF15

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGEF15 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGEF15 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGEF15
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGEF15 (see all 24):
    hsa-miR-485-5p hsa-miR-193a-3p hsa-miR-136 hsa-miR-4288 hsa-let-7d hsa-miR-3660 hsa-miR-632 hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF15 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARHGEF15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF15

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARHGEF15
    Sirion Biotech Customized adenovirus for overexpression of ARHGEF15

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for ARHGEF15 (see all 7)
    OriGene ORF clones in mouse, rat for ARHGEF15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ARHGEF15 (NM_173728)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF15
    Sirion Biotech Customized lentivirus for stable overexpression of ARHGEF15 
                         Customized lentivirus expression plasmids for stable overexpression of ARHGEF15 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARHGEF15
    Search LifeMap BioReagents cell lines for ARHGEF15
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF15


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGEF15 About   (see all 15)                                                                                              See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Pancreatic Adenocarcinoma0.59
    GPCR Pathway0.62
    Breast Cancer Regulation by Stathmin10.58
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    3G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    G-AlphaI Signaling0.47
    4fMLP Pathway
    CXCR4 Pathway0.39
    Internalin Pathway0.31
    5TGF-Beta Pathway
    MAPK Family Pathway0.60

    5/19 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGEF15 (see all 19)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling

    2 BioSystems Pathways for ARHGEF15
        Regulation of RhoA activity
    EPHA forward signaling


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGEF15

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/9 Interacting proteins for ARHGEF15 (O949892, 3 ENSP000003550264) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MOB4Q9Y3A32, 3, ENSP000003157024MINT-66097 I2D: score=5 STRING: ENSP00000315702
    UBE3AQ050863, ENSP000003810454I2D: score=1 STRING: ENSP00000381045
    EPHA4P547643, ENSP000002818214I2D: score=2 STRING: ENSP00000281821
    C11orf49Q9H6J73, ENSP000003678784I2D: score=5 STRING: ENSP00000367878
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0035023regulation of Rho protein signal transduction IEA--
    GO:0050790regulation of catalytic activity IDA12775584
    GO:0061299retina vasculature morphogenesis in camera-type eye IEA--
    GO:2000297negative regulation of synapse maturation ISS--

    ARHGEF15 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGEF15 (ARHGF)

    Search CenterWatch for drugs/clinical trials and news about ARHGEF15 / ARHGF

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGEF15 gene (2 alternative transcripts): 
    NM_025014.1  NM_173728.3  

    Unigene Cluster for ARHGEF15:

    Rho guanine nucleotide exchange factor (GEF) 15
    Hs.443109  [show with all ESTs]
    Unigene Representative Sequence: BC036749
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000583529 ENST00000455564(uc002glb.2) ENST00000361926(uc002glc.3 uc002gld.3 uc010vuw.2)
    ENST00000579439 ENST00000581809 ENST00000578286 ENST00000582060 ENST00000421050

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGEF15
    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGEF15 (see all 24):
    hsa-miR-485-5p hsa-miR-193a-3p hsa-miR-136 hsa-miR-4288 hsa-let-7d hsa-miR-3660 hsa-miR-632 hsa-let-7c
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF15 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for ARHGEF15
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF15
    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGEF15 (see all 7)
    OriGene ORF clones in mouse, rat for ARHGEF15
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): ARHGEF15 (NM_173728)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGEF15
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF15
    Sirion Biotech Customized lentivirus for stable overexpression of ARHGEF15 
                         Customized lentivirus expression plasmids for stable overexpression of ARHGEF15 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARHGEF15
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF15
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF15
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF15
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF15

    Additional mRNA sequence: 

    AB020722.1 AK291626.1 AK300327.1 BC036749.1 

    5 DOTS entries:

    DT.441535  DT.120926831  DT.120926830  DT.97804904  DT.120926822 

    24/79 AceView cDNA sequences (see all 79):

    W21162 CA439135 BQ787423 BM849066 BC036749 BM701263 CK823093 BQ101069 
    AB020722 BQ004849 NM_173728 AA707157 BM973464 BQ100782 BM711432 BX504159 
    AA448382 AA613864 BQ877184 AI216395 AI004760 AA708818 AW003155 AI825125 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF15    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
    SP1:        -                                   -     -     -                                                                           
    SP2:                                                                                                                                    
    SP3:        -                                                                                                                           
    SP4:                                                                                                                                    


    ECgene alternative splicing isoforms for ARHGEF15

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGEF15 expression in normal human tissues (normalized intensities)      ARHGEF15 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACATTGGAGA
    ARHGEF15 Expression
    About this image


    ARHGEF15 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Breast (Uncategorized)
             breast lobular cells   
     
     Pancreas (Endocrine System)
             Posterior foregut-like cells ( A scalable, suspension protocol for derivation of...

    See ARHGEF15 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGEF15

    SOURCE GeneReport for Unigene cluster: Hs.443109

    UniProtKB/Swiss-Prot: ARHGF_HUMAN, O94989
    Tissue specificity: Expressed in the vascular smooth muscle of coronary artery

        SABiosciences Custom PCR Arrays for ARHGEF15
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for ARHGEF15
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF15
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF15
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF15
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF15
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF15

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF15 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef151 , 5 Rho guanine nucleotide exchange factor (GEF) 151, 5 84.33(n)1
    85.48(a)1
      11 (42.21 cM)5
    4428011  NM_177566.31  NP_808234.21 
     689431575 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF156
    Uncharacterized protein
    40(a)
    1 ↔ 1
    GL343466.1(36161-52635)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia BQ523609.12   -- 82.69(n)    BQ523609.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgef156
    ARHGEF156
    (see all 3)
    Rho guanine nucleotide exchange factor (GEF) 15
    (see all 3)
    41(a)
    37(a)
    (see all 3)
    possible ortholog
    1 ↔ 1
    (see all 3)
    5(63299498-63332021)
    6(26641178-26653666)
    fruit fly
    (Drosophila melanogaster)
    Insecta Exn6
    Ephexin
    9(a)
    1 → many
    3L(16963113-16987488)
    worm
    (Caenorhabditis elegans)
    Secernentea tag-2186
    Protein TAG-218, isoform a
    15(a)
    1 → many
    II(4004889-4016077)


    ENSEMBL Gene Tree for ARHGEF15 (if available)
    TreeFam Gene Tree for ARHGEF15 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGEF15 gene
    ARHGEF192  ARHGEF162  NGEF2  ARHGEF52  ARHGEF262  
    4 SIMAP similar genes for ARHGEF15 using alignment to 5 protein entries:     ARHGF_HUMAN (see all proteins):
    ARHGEF19    ARHGEF16    LOC728377    NGEF

    ARHGEF15 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/413 SNPs in ARHGEF15 are shown (see all 413)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1887217911,2
    --8211669(+) CCCTGC/TCTCTA 1 -- us2k10--------
    rs1929718911,2
    C--8211734(+) TATTCA/GGGAGA 1 -- us2k10--------
    rs1842690111,2
    C--8211796(+) AGATCA/C/GCACCA 1 -- us2k10--------
    rs745614991,2
    C--8211835(+) GACTCC/TGTCTC 1 -- us2k10--------
    rs1433126211,2
    --8211891(+) GTTTTC/TATTGG 1 -- us2k10--------
    rs1887429451,2
    --8212025(+) GCACGA/GTCTCA 1 -- us2k10--------
    rs1118558121,2
    C--8212106(+) CAGGCA/GAGTGC 1 -- us2k10--------
    rs1836572541,2
    --8212275(+) GTGCCC/TGCCAC 2 -- us2k10--------
    rs1115997451,2
    C,F--8212276(+) TGCCCG/ACCACC 2 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1475238191,2
    --8212325(+) GATGGA/GGTTTC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGEF15 (8213556 - 8225834 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for ARHGEF15:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv527633CNV Loss19592680
    nsv1967CNV Loss18451855
    nsv833353CNV Loss17160897
    nsv907661CNV Gain21882294
    nsv457664CNV Gain19166990
    nsv470576CNV Gain18288195

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGEF15
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGEF15

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608504    OMIM disorders: --

    4 diseases for ARHGEF15:    About MalaCards
    spasticity    adenocarcinoma    pancreatitis    breast cancer


    ARHGEF15 for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGEF15
    Human Genome Epidemiology (HuGE) Navigator: ARHGEF15 (1 document)

    Export disorders for ARHGEF15 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGEF15 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ARHGEF15)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10048485)1, 2, 3 Nagase T....Ohara O. (1998)
    2. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. (PubMed id 12775584)1, 2, 9 Ogita H.... Mochizuki N. (2003)
    3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    7. Arhgef15 promotes retinal angiogenesis by mediating VE GF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial ce lls. (PubMed id 23029280)1 Kusuhara S....Uemura A. (2012)
    8. EphB-mediated degradation of the RhoA GEF Ephexin5 re lieves a developmental brake on excitatory synapse formation. (PubMed id 21029865)1 Margolis S.S....Greenberg M.E. (2010)
    9. Ephecting excitatory synapse development. (PubMed id 21029857)1 Dalva M.B. (2010)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 22899 HGNC: 15590 AceView: ARHGEF15 Ensembl:ENSG00000198844 euGenes: HUgn22899
    ECgene: ARHGEF15 H-InvDB: ARHGEF15

    (According to HUGE)
    About This Section
    HUGE: KIAA0915

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGEF15 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGEF15 gene:
    Search GeneIP for patents involving ARHGEF15

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for ARHGEF15  
     OriGene qPCR primer pairs and template standards for ARHGEF15   OriGene Protein Over-expression Lysate for ARHGEF15  
     OriGene MassSpec something-or-other for ARHGEF15   OriGene clones in human, mouse for ARHGEF15  
     OriGene qSTAR qPCR primer pairs in human, mouse for ARHGEF15   OriGene Purified Protein for ARHGEF15  
     OriGene ORF clones in mouse, rat for ARHGEF15   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for ARHGEF15   OriGene Custom Protein Services for ARHGEF15  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGEF15
     QIAGEN SeqTarget long-range PCR primers for resequencing ARHGEF15
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF15
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF15
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF15
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF15
     GenScript Custom Purified and Recombinant Proteins Services for ARHGEF15 GenScript cDNA clones with any tag delivered in your preferred vector for ARHGEF15
     GenScript Custom Assay Services for ARHGEF15 GenScript Custom Superior Antibodies Services for ARHGEF15
     GenScript Custom overexpressing Cell Line Services for ARHGEF15 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in ARHGEF15 promoter
     Search Chromatin IP Primers for ARHGEF15
     RT2 qPCR Primer Assay in human, mouse, rat ARHGEF15
     GNC Network for ARHGEF15
     SABiosciences PCR Arrays including human, mouse, rat ARHGEF15
     Search Tocris compounds for ARHGEF15 (ARHGF)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     ARHGEF15 antibodies
     ARHGEF15 lysates
     Antibodies for ARHGEF15
     See all of Abcam's Antibodies, Kits and Proteins for ARHGEF15
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for ARHGEF15
     Antibodies for ARHGEF15
     ELISAs for ARHGEF15
     CLIAs for ARHGEF15
     Search LifeMap BioReagents cell lines for ARHGEF15
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF15
     SwitchGear 3'UTR luciferase reporter plasmids for ARHGEF15
     SwitchGear Promoter luciferase reporter plasmids for ARHGEF15
     Search ThermoFisher Antibodies for ARHGEF15
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF15
     inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGEF15
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARHGEF15
    Customized:
     lentivirus for stable overexpression of ARHGEF15
     lentivirus expression plasmids for stable overexpression of ARHGEF15
     adenovirus for overexpression of ARHGEF15
     LSBio Antibodies in human, mouse, rat for ARHGEF15
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      ARHGEF15 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4