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Aliases for ARHGEF15 Gene

Aliases for ARHGEF15 Gene

  • Rho Guanine Nucleotide Exchange Factor 15 2 3 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 15 2 3
  • Vsm-RhoGEF 3 4
  • Ephexin-5 3 4
  • E5 3 4
  • Rho Guanine Exchange Factor (GEF) 15 2
  • Ephexin5 3
  • KIAA0915 4
  • ARGEF15 3

External Ids for ARHGEF15 Gene

Previous GeneCards Identifiers for ARHGEF15 Gene

  • GC17P008591
  • GC17P009307
  • GC17P008156
  • GC17P008414
  • GC17P008154
  • GC17P008108
  • GC17P008213

Summaries for ARHGEF15 Gene

Entrez Gene Summary for ARHGEF15 Gene

  • Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for ARHGEF15 Gene

ARHGEF15 (Rho Guanine Nucleotide Exchange Factor 15) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCR Pathway. GO annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF5.

UniProtKB/Swiss-Prot for ARHGEF15 Gene

  • Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF15 Gene

Genomics for ARHGEF15 Gene

Regulatory Elements for ARHGEF15 Gene

Enhancers for ARHGEF15 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F008846 0.8 ENCODE 11.1 +536.5 536522 0.9 ZNF263 USF1 HCFC1 HLF TEAD4 NFYC MAX SIX5 USF2 ETS1 RPL26 ENSG00000226871 ARHGEF15 SPDYE4 PIK3R6 MFSD6L
GH17F007454 0.2 ENCODE 11.1 -854.3 -854258 2.0 HDGF ATF1 PKNOX1 CREB3L1 ZNF493 ZFP64 SIN3A FEZF1 ETS1 YY1 DVL2 PFAS CNTROB CTC1 LOC105371523 CHRNB1 NLGN2 SNORA48 SNORD10 NEURL4
GH17F007854 0.6 ENCODE 11.1 -453.3 -453273 5.0 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 LOC105371523 SNORA48 ACAP1 SNORD10 DVL2 RPL26 PFAS ENSG00000226871 CYB5D1 NLGN2
GH17F007434 0.7 ENCODE 11.1 -873.5 -873504 4.0 PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A YY1 SLC30A9 ZNF143 KLF13 DEK DVL2 RPL26 SNORA48 MIR324 PFAS SENP3 ENSG00000262067 ENSG00000271029 ZBTB4 SPEM1
GH17F007571 0.7 ENCODE 11.1 -732.1 -732080 14.2 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF416 ZNF143 DVL2 SNORD10 SNORA48 PFAS LOC105371523 CTC1 CNTROB MIR6883 KCTD11 MIR324
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARHGEF15 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGEF15 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001340453 762 1201 KLF1 POLR2A ZNF580 FOXP2 ZNF384 KDM1A MYC EGR2

Genomic Location for ARHGEF15 Gene

Chromosome:
17
Start:
8,310,238 bp from pter
End:
8,322,516 bp from pter
Size:
12,279 bases
Orientation:
Plus strand

Genomic View for ARHGEF15 Gene

Genes around ARHGEF15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF15 Gene

Proteins for ARHGEF15 Gene

  • Protein details for ARHGEF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94989-ARHGF_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 15
    Protein Accession:
    O94989
    Secondary Accessions:
    • A8K6G1
    • Q8N449
    • Q9H8B4

    Protein attributes for ARHGEF15 Gene

    Size:
    841 amino acids
    Molecular mass:
    91940 Da
    Quaternary structure:
    • Interacts with EPHB2 (By similarity). Interacts with EPHA4.
    SequenceCaution:
    • Sequence=BAA74938.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ARHGEF15 Gene

Post-translational modifications for ARHGEF15 Gene

  • Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-353 triggers UBE3A-mediated ubiquitination (By similarity).
  • Ubiquitinated; UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGEF15 Gene

Domains & Families for ARHGEF15 Gene

Gene Families for ARHGEF15 Gene

Protein Domains for ARHGEF15 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ARHGEF15 Gene

Graphical View of Domain Structure for InterPro Entry

O94989

UniProtKB/Swiss-Prot:

ARHGF_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
genes like me logo Genes that share domains with ARHGEF15: view

Function for ARHGEF15 Gene

Molecular function for ARHGEF15 Gene

UniProtKB/Swiss-Prot Function:
Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.

Gene Ontology (GO) - Molecular Function for ARHGEF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,ISS --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 12775584
genes like me logo Genes that share ontologies with ARHGEF15: view
genes like me logo Genes that share phenotypes with ARHGEF15: view

Animal Models for ARHGEF15 Gene

MGI Knock Outs for ARHGEF15:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGEF15 Gene

Localization for ARHGEF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF15 Gene

Cell projection, dendrite. Note=Expressed exclusively in dendrites of the developing hippocampus. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF15 Gene COMPARTMENTS Subcellular localization image for ARHGEF15 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARHGEF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0030425 dendrite ISS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with ARHGEF15: view

Pathways & Interactions for ARHGEF15 Gene

genes like me logo Genes that share pathways with ARHGEF15: view

Gene Ontology (GO) - Biological Process for ARHGEF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0050790 regulation of catalytic activity IDA 12775584
GO:0051496 positive regulation of stress fiber assembly ISS --
GO:0061299 retina vasculature morphogenesis in camera-type eye IEA --
genes like me logo Genes that share ontologies with ARHGEF15: view

No data available for SIGNOR curated interactions for ARHGEF15 Gene

Transcripts for ARHGEF15 Gene

Unigene Clusters for ARHGEF15 Gene

Rho guanine nucleotide exchange factor (GEF) 15:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF15 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2:
SP3: -
SP4:

Relevant External Links for ARHGEF15 Gene

GeneLoc Exon Structure for
ARHGEF15
ECgene alternative splicing isoforms for
ARHGEF15

Expression for ARHGEF15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF15 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.5) and Adipose - Subcutaneous (x4.8).

Protein differential expression in normal tissues from HIPED for ARHGEF15 Gene

This gene is overexpressed in Placenta (35.5) and Synovial fluid (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGEF15 Gene



Protein tissue co-expression partners for ARHGEF15 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF15 Gene:

ARHGEF15

SOURCE GeneReport for Unigene cluster for ARHGEF15 Gene:

Hs.443109

mRNA Expression by UniProt/SwissProt for ARHGEF15 Gene:

O94989-ARHGF_HUMAN
Tissue specificity: Expressed in the vascular smooth muscle of coronary artery.
genes like me logo Genes that share expression patterns with ARHGEF15: view

Primer Products

Orthologs for ARHGEF15 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF15 34 35
  • 99.33 (n)
cow
(Bos Taurus)
Mammalia ARHGEF15 34 35
  • 87.28 (n)
dog
(Canis familiaris)
Mammalia ARHGEF15 34 35
  • 86.26 (n)
mouse
(Mus musculus)
Mammalia Arhgef15 34 16 35
  • 84.33 (n)
rat
(Rattus norvegicus)
Mammalia Arhgef15 34
  • 83 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF15 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 37 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ARHGEF15 35
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arhgef15 35
  • 42 (a)
OneToMany
ARHGEF15 (2 of 2) 35
  • 29 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Exn 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ephx-1 35
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 29 (a)
OneToMany
Species where no ortholog for ARHGEF15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGEF15 Gene

ENSEMBL:
Gene Tree for ARHGEF15 (if available)
TreeFam:
Gene Tree for ARHGEF15 (if available)

Paralogs for ARHGEF15 Gene

Paralogs for ARHGEF15 Gene

(4) SIMAP similar genes for ARHGEF15 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGEF15: view

Variants for ARHGEF15 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs140557878 Likely benign 8,320,909(+) CACGA(A/G)AGGAG reference, synonymous-codon, utr-variant-3-prime
rs199691980 Likely benign 8,315,281(+) AGGTG(A/G)GAGCT intron-variant
rs373534537 Likely benign 8,318,645(+) GGCTG(A/C/T)GCTTC reference, missense
rs193921031 Uncertain significance 8,318,774(+) GGTCA(C/T)GGCGC reference, missense
rs587777166 Uncertain significance 8,318,600(+) TGGGG(C/T)GCATG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF15 Gene

Variant ID Type Subtype PubMed ID
esv3639881 CNV gain 21293372
esv3639882 CNV gain 21293372
nsv1967 CNV deletion 18451855
nsv457664 CNV gain 19166990
nsv470576 CNV gain 18288195
nsv527633 CNV loss 19592680
nsv574337 CNV gain 21841781
nsv833353 CNV loss 17160897

Variation tolerance for ARHGEF15 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF15 Gene

Human Gene Mutation Database (HGMD)
ARHGEF15
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF15 Gene

Disorders for ARHGEF15 Gene

Relevant External Links for ARHGEF15

Genetic Association Database (GAD)
ARHGEF15
Human Genome Epidemiology (HuGE) Navigator
ARHGEF15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF15

No disorders were found for ARHGEF15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF15 Gene

Publications for ARHGEF15 Gene

  1. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. (PMID: 12775584) Ogita H. … Mochizuki N. (Circ. Res. 2003) 3 4 22 64
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4 64
  3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 46 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for ARHGEF15 Gene

Sources for ARHGEF15 Gene

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