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Aliases for ARHGEF15 Gene

Aliases for ARHGEF15 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 15 2 3
  • Vsm-RhoGEF 3 4
  • Ephexin-5 3 4
  • E5 3 4
  • Rho Guanine Exchange Factor (GEF) 15 2
  • Ephexin5 3
  • KIAA0915 4
  • ARGEF15 3

External Ids for ARHGEF15 Gene

Previous GeneCards Identifiers for ARHGEF15 Gene

  • GC17P008591
  • GC17P009307
  • GC17P008156
  • GC17P008414
  • GC17P008154
  • GC17P008108
  • GC17P008213

Summaries for ARHGEF15 Gene

Entrez Gene Summary for ARHGEF15 Gene

  • Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for ARHGEF15 Gene

ARHGEF15 (Rho Guanine Nucleotide Exchange Factor (GEF) 15) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.

UniProtKB/Swiss-Prot for ARHGEF15 Gene

  • Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF15 Gene

Genomics for ARHGEF15 Gene

Regulatory Elements for ARHGEF15 Gene

Genomic Location for ARHGEF15 Gene

Chromosome:
17
Start:
8,310,238 bp from pter
End:
8,322,516 bp from pter
Size:
12,279 bases
Orientation:
Plus strand

Genomic View for ARHGEF15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF15 Gene

Proteins for ARHGEF15 Gene

  • Protein details for ARHGEF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O94989-ARHGF_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 15
    Protein Accession:
    O94989
    Secondary Accessions:
    • A8K6G1
    • Q8N449
    • Q9H8B4

    Protein attributes for ARHGEF15 Gene

    Size:
    841 amino acids
    Molecular mass:
    91940 Da
    Quaternary structure:
    • Interacts with EPHB2 (By similarity). Interacts with EPHA4.
    SequenceCaution:
    • Sequence=BAA74938.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ARHGEF15 Gene

Proteomics data for ARHGEF15 Gene at MOPED

Post-translational modifications for ARHGEF15 Gene

  • Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-353 triggers UBE3A-mediated ubiquitination (By similarity).
  • Ubiquitinated; UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF15 Gene

No data available for DME Specific Peptides for ARHGEF15 Gene

Domains & Families for ARHGEF15 Gene

Gene Families for ARHGEF15 Gene

Protein Domains for ARHGEF15 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for ARHGEF15 Gene

Graphical View of Domain Structure for InterPro Entry

O94989

UniProtKB/Swiss-Prot:

ARHGF_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
genes like me logo Genes that share domains with ARHGEF15: view

Function for ARHGEF15 Gene

Molecular function for ARHGEF15 Gene

UniProtKB/Swiss-Prot Function:
Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.

Gene Ontology (GO) - Molecular Function for ARHGEF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity ISS --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 12775584
genes like me logo Genes that share ontologies with ARHGEF15: view
genes like me logo Genes that share phenotypes with ARHGEF15: view

Animal Models for ARHGEF15 Gene

MGI Knock Outs for ARHGEF15:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGEF15

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for ARHGEF15 Gene

Localization for ARHGEF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF15 Gene

Cell projection, dendrite. Note=Expressed exclusively in dendrites of the developing hippocampus. {ECO:0000250}.

Gene Ontology (GO) - Cellular Components for ARHGEF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0030425 dendrite ISS --
genes like me logo Genes that share ontologies with ARHGEF15: view

No data available for Subcellular locations from COMPARTMENTS for ARHGEF15 Gene

Pathways & Interactions for ARHGEF15 Gene

genes like me logo Genes that share pathways with ARHGEF15: view

Pathways by source for ARHGEF15 Gene

2 BioSystems pathways for ARHGEF15 Gene

Gene Ontology (GO) - Biological Process for ARHGEF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity ISS --
GO:0050790 regulation of catalytic activity IDA 12775584
GO:0051496 positive regulation of stress fiber assembly ISS --
GO:0061299 retina vasculature morphogenesis in camera-type eye IEA --
genes like me logo Genes that share ontologies with ARHGEF15: view

No data available for SIGNOR curated interactions for ARHGEF15 Gene

Drugs & Compounds for ARHGEF15 Gene

No Compound Related Data Available

Transcripts for ARHGEF15 Gene

Unigene Clusters for ARHGEF15 Gene

Rho guanine nucleotide exchange factor (GEF) 15:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGEF15

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF15 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP2:
SP3: -
SP4:

Relevant External Links for ARHGEF15 Gene

GeneLoc Exon Structure for
ARHGEF15
ECgene alternative splicing isoforms for
ARHGEF15

Expression for ARHGEF15 Gene

mRNA expression in normal human tissues for ARHGEF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF15 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x5.5) and Adipose - Subcutaneous (x4.8).

Protein differential expression in normal tissues from HIPED for ARHGEF15 Gene

This gene is overexpressed in Placenta (35.5) and Synovial fluid (28.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGEF15 Gene



SOURCE GeneReport for Unigene cluster for ARHGEF15 Gene Hs.443109

mRNA Expression by UniProt/SwissProt for ARHGEF15 Gene

O94989-ARHGF_HUMAN
Tissue specificity: Expressed in the vascular smooth muscle of coronary artery.
genes like me logo Genes that share expression patterns with ARHGEF15: view

Protein tissue co-expression partners for ARHGEF15 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for ARHGEF15 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF15 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGEF15 35
  • 87.28 (n)
  • 88.59 (a)
ARHGEF15 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF15 35
  • 86.26 (n)
  • 88.75 (a)
ARHGEF15 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef15 35
  • 84.33 (n)
  • 85.48 (a)
Arhgef15 16
Arhgef15 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF15 35
  • 99.33 (n)
  • 99.05 (a)
ARHGEF15 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef15 35
  • 83 (n)
  • 84.7 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF15 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 37 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia ARHGEF15 36
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii arhgef15 36
  • 42 (a)
OneToMany
ARHGEF15 (2 of 2) 36
  • 29 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Exn 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ephx-1 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for ARHGEF15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGEF15 Gene

ENSEMBL:
Gene Tree for ARHGEF15 (if available)
TreeFam:
Gene Tree for ARHGEF15 (if available)

Paralogs for ARHGEF15 Gene

Paralogs for ARHGEF15 Gene

(4) SIMAP similar genes for ARHGEF15 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGEF15: view

Variants for ARHGEF15 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs397694918 -- 8,314,045(+) AAAAA(-/A)TCTGT intron-variant, utr-variant-5-prime
rs397856986 -- 8,319,957(+) TTTTT(-/T)AATGG intron-variant
rs527631197 -- 8,311,606(+) CCAGA(C/T)AGCGC intron-variant
rs528039193 -- 8,315,925(+) GGGGT(A/G)GGGAG intron-variant
rs528176993 -- 8,317,794(+) AGGCA(C/T)GGTGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF15 Gene

Variant ID Type Subtype PubMed ID
nsv833353 CNV Loss 17160897
nsv907661 CNV Gain 21882294
nsv470576 CNV Gain 18288195
nsv527633 CNV Loss 19592680
nsv1967 CNV Loss 18451855
nsv457664 CNV Gain 19166990

Variation tolerance for ARHGEF15 Gene

Residual Variation Intolerance Score: 70.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.72; 66.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF15 Gene

HapMap Linkage Disequilibrium report
ARHGEF15
Human Gene Mutation Database (HGMD)
ARHGEF15

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF15 Gene

Disorders for ARHGEF15 Gene

Relevant External Links for ARHGEF15

Genetic Association Database (GAD)
ARHGEF15
Human Genome Epidemiology (HuGE) Navigator
ARHGEF15
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF15
genes like me logo Genes that share disorders with ARHGEF15: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF15 Gene

Publications for ARHGEF15 Gene

  1. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. (PMID: 12775584) Ogita H. … Mochizuki N. (Circ. Res. 2003) 23 67
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 67
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  4. Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells. (PMID: 23029280) Kusuhara S. … Uemura A. (PLoS ONE 2012) 67
  5. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 67

Products for ARHGEF15 Gene

Sources for ARHGEF15 Gene

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