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Aliases for ARHGEF15 Gene

Aliases for ARHGEF15 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 15 2 3
  • Vsm-RhoGEF 3 4
  • Ephexin-5 3 4
  • KIAA0915 4 6
  • ARGEF15 3 6
  • E5 3 4
  • Rho Guanine Nucleotide Exchange Factor 15 3
  • Rho Guanine Exchange Factor (GEF) 15 2
  • Ephexin5 3

External Ids for ARHGEF15 Gene

Summaries for ARHGEF15 Gene

Entrez Gene Summary for ARHGEF15 Gene

  • Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein-coupled receptors. This gene encodes a protein that functions as a specific guanine nucleotide exchange factor for RhoA. It also interacts with ephrin A4 in vascular smooth muscle cells. Two alternatively spliced transcripts variants that encode the same protein have been found for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for ARHGEF15 Gene

ARHGEF15 (Rho Guanine Nucleotide Exchange Factor (GEF) 15) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and ERK Signaling. GO annotations related to this gene include GTPase activator activity and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF19.

UniProtKB/Swiss-Prot for ARHGEF15 Gene

  • Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF15 Gene

Genomics for ARHGEF15 Gene

Genomic Location for ARHGEF15 Gene

8,310,238 bp from pter
8,322,516 bp from pter
12,279 bases
Plus strand

Genomic View for ARHGEF15 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF15 Gene

Regulatory Elements for ARHGEF15 Gene

Proteins for ARHGEF15 Gene

  • Protein details for ARHGEF15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 15
    Protein Accession:
    Secondary Accessions:
    • A8K6G1
    • Q8N449
    • Q9H8B4

    Protein attributes for ARHGEF15 Gene

    841 amino acids
    Molecular mass:
    91940 Da
    Quaternary structure:
    • Interacts with EPHB2 (By similarity). Interacts with EPHA4.
    • Sequence=BAA74938.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for ARHGEF15 Gene

Proteomics data for ARHGEF15 Gene at MOPED

Post-translational modifications for ARHGEF15 Gene

  • Phosphorylated on tyrosine residues upon EFNA1 stimulation. EPHB2-dependent phosphorylation at Tyr-353 triggers UBE3A-mediated ubiquitination (By similarity).
  • Ubiquitinated; UBE3A-mediated ubiquitination and degradation by the proteasome promotes EFNB1-dependent synapse formation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF15 Gene

No data available for DME Specific Peptides for ARHGEF15 Gene

Domains for ARHGEF15 Gene

Gene Families for ARHGEF15 Gene

  • ARHGEF :Rho guanine nucleotide exchange factors

Protein Domains for ARHGEF15 Gene



  • Contains 1 DH (DBL-homology) domain.:
    • O94989
genes like me logo Genes that share domains with ARHGEF15: view

Function for ARHGEF15 Gene

Molecular function for ARHGEF15 Gene

UniProtKB/Swiss-Prot Function: Specific GEF for RhoA activation. Does not activate RAC1 or CDC42. Regulates vascular smooth muscle contractility. Negatively regulates excitatory synapse development by suppressing the synapse-promoting activity of EPHB2.

Gene Ontology (GO) - Molecular Function for ARHGEF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity ISS --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 12775584
genes like me logo Genes that share ontologies with ARHGEF15: view
genes like me logo Genes that share phenotypes with ARHGEF15: view

Animal Models for ARHGEF15 Gene

MGI Knock Outs for ARHGEF15:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGEF15 Gene

Localization for ARHGEF15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF15 Gene

Cell projection, dendrite. Note=Expressed exclusively in dendrites of the developing hippocampus. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for ARHGEF15 Gene COMPARTMENTS Subcellular localization image for ARHGEF15 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for ARHGEF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0030425 dendrite ISS --
genes like me logo Genes that share ontologies with ARHGEF15: view

Pathways for ARHGEF15 Gene

genes like me logo Genes that share pathways with ARHGEF15: view

Pathways by source for ARHGEF15 Gene

Gene Ontology (GO) - Biological Process for ARHGEF15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction --
GO:0043547 positive regulation of GTPase activity ISS --
GO:0050790 regulation of catalytic activity IDA 12775584
GO:0051496 positive regulation of stress fiber assembly ISS --
GO:0061299 retina vasculature morphogenesis in camera-type eye IEA --
genes like me logo Genes that share ontologies with ARHGEF15: view

Transcripts for ARHGEF15 Gene

Unigene Clusters for ARHGEF15 Gene

Rho guanine nucleotide exchange factor (GEF) 15:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF15 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - - - -
SP3: -

Relevant External Links for ARHGEF15 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGEF15 Gene

mRNA expression in normal human tissues for ARHGEF15 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF15 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (5.5) and Adipose - Subcutaneous (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARHGEF15 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF15 Gene Hs.443109

mRNA Expression by UniProt/SwissProt for ARHGEF15 Gene

Tissue specificity: Expressed in the vascular smooth muscle of coronary artery.
genes like me logo Genes that share expressions with ARHGEF15: view

Orthologs for ARHGEF15 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF15 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGEF15 36
  • 99.33 (n)
  • 99.05 (a)
  • 99 (a)
(Bos Taurus)
Mammalia ARHGEF15 36
  • 87.28 (n)
  • 88.59 (a)
  • 87 (a)
(Canis familiaris)
Mammalia ARHGEF15 36
  • 86.26 (n)
  • 88.75 (a)
  • 89 (a)
(Mus musculus)
Mammalia Arhgef15 36
  • 84.33 (n)
  • 85.48 (a)
Arhgef15 16
Arhgef15 37
  • 84 (a)
(Monodelphis domestica)
Mammalia ARHGEF15 37
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 37 (a)
(Rattus norvegicus)
Mammalia Arhgef15 36
  • 83 (n)
  • 84.7 (a)
(Anolis carolinensis)
Reptilia ARHGEF15 37
  • 38 (a)
(Danio rerio)
Actinopterygii arhgef15 37
  • 42 (a)
ARHGEF15 (2 of 2) 37
  • 29 (a)
fruit fly
(Drosophila melanogaster)
Insecta Exn 37
  • 12 (a)
(Caenorhabditis elegans)
Secernentea ephx-1 37
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 29 (a)
Species with no ortholog for ARHGEF15:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for ARHGEF15 Gene

Gene Tree for ARHGEF15 (if available)
Gene Tree for ARHGEF15 (if available)

Paralogs for ARHGEF15 Gene

Paralogs for ARHGEF15 Gene

Selected SIMAP similar genes for ARHGEF15 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGEF15: view

Variants for ARHGEF15 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF15 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs2430 -- 8,322,469(-) GTCAG(A/G)CACCC utr-variant-3-prime
rs871841 - 8,313,150(-) TGAGG(A/G)GTGGC missense, reference, upstream-variant-2KB
rs1045161 -- 8,321,352(+) AAGTC(C/G)TAGGA utr-variant-3-prime
rs1045172 -- 8,322,450(+) ATTGG(A/G)GACTC utr-variant-3-prime
rs1115340 -- 8,320,086(+) TGTTT(C/T)attta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF15 Gene

Variant ID Type Subtype PubMed ID
nsv833353 CNV Loss 17160897
nsv907661 CNV Gain 21882294
nsv470576 CNV Gain 18288195
nsv527633 CNV Loss 19592680
nsv1967 CNV Loss 18451855
nsv457664 CNV Gain 19166990

Relevant External Links for ARHGEF15 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ARHGEF15 Gene

Relevant External Links for ARHGEF15

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ARHGEF15: view

No data available for UniProtKB/Swiss-Prot for ARHGEF15 Gene

Publications for ARHGEF15 Gene

  1. EphA4-mediated Rho activation via Vsm-RhoGEF expressed specifically in vascular smooth muscle cells. (PMID: 12775584) Ogita H. … Mochizuki N. (Circ. Res. 2003) 3 4 23
  2. Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10048485) Nagase T. … Ohara O. (DNA Res. 1998) 2 3 4
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for ARHGEF15 Gene

Sources for ARHGEF15 Gene

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