Aliases for ARHGEF12 Gene
External Ids for ARHGEF12 Gene
Previous GeneCards Identifiers for ARHGEF12 Gene
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
GeneCards Summary for ARHGEF12 Gene
ARHGEF12 (Rho Guanine Nucleotide Exchange Factor (GEF) 12) is a Protein Coding gene. Diseases associated with ARHGEF12 include leukemia, acute myeloid and leukemia. Among its related pathways are Signaling by FGFR and RhoGDI Pathway. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF11.
UniProtKB/Swiss-Prot for ARHGEF12 Gene
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.