ARHGEF12 Gene
protein-coding GIFtS: 66
GCID: GC11P120207
|
|
Rho guanine nucleotide exchange factor (GEF) 12
| |
Aliases
for ARHGEF12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho Guanine Nucleotide Exchange Factor (GEF) 121 2 | | PRO27922 | | LARG1 2 3 5 | | Leukemia-Associated Rho Guanine Nucleotide Exchange Factor2 | | KIAA03821 3 5 | | Rho Guanine Nucleotide Exchange Factor 122 | | Leukemia-Associated RhoGEF2 3 | | |
Export aliases for ARHGEF12 gene to outside databasesPrevious GC identifers: GC11P122207 GC11P121719 GC11P120241 GC11P119745 GC11P119712 GC11P116148 |
Summaries
for ARHGEF12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARHGEF12:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli workingthrough G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulateRho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloidleukemia. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Nov2010)
UniProtKB/Swiss-Prot: ARHGC_HUMAN, Q9NZN5Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13(GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein(GAP) for GNA12 and GNA13
Gene Wiki entry for ARHGEF12
|
Genomic Views
for ARHGEF12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_033899.8
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGEF12 gene promoter:
AML1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGEF12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q23.3 Ensembl cytogenetic band: 11q23.3 HGNC cytogenetic band: 11q23.3ARHGEF12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P120207: view genomic region
(about GC identifiers)
Start:
|
120,207,787 bp from pter |
End:
|
120,360,645 bp from pter |
Size:
|
152,859 bases |
Orientation:
|
plus strand |
|
Proteins
for ARHGEF12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARHGC_HUMAN, Q9NZN5 (See
protein sequence)Recommended Name: Rho guanine nucleotide exchange factor 12 Size: 1544 amino acids; 173232 Da
Subunit: Interacts with GNA12 and GNA13, probably through the RGS-like domain. Interacts with RHOA, PLXNB1 and PLXNB2.Interacts through its PDZ domain with IGF1R beta subunit. Interacts with GCSAM
Subcellular location: Cytoplasm (Probable). Membrane (Probable). Note=Translocated to the membrane upon stimulation(Probable)
Sequence caution: Sequence=AAH63117.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-Asequence;
4 PDB 3D structures from  and Proteopedia  for ARHGEF12:1TXD (3D)
1X86 (3D)
2OMJ (3D)
2OS6 (3D)
Secondary accessions: O15086 Q6P526Alternative splicing: 2 isoforms: Q9NZN5-1 Q9NZN5-2 (Contains a phosphoserine at position 41)Explore the universe of human proteins at neXtProt for ARHGEF12: NX_Q9NZN5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9NZN5
ARHGEF12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001185594.1 NP_056128.1
ENSEMBL proteins: ENSP00000380942 ENSP00000432984 ENSP00000349056 Reactome Protein details: Q9NZN5
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ARHGEF12 for ontologies About GeneDecksing
ARHGEF12 Antibody Products:
Assay Products for ARHGEF12: |
Protein
Domains /
Families
for ARHGEF12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGEF12 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9NZN5ProtoNet protein and cluster: Q9NZN5 3 Blocks protein families: IPB000219 DH domain IPB001478 PDZ/DHR/GLGF domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: ARHGC_HUMAN, Q9NZN5Similarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 RGSL (RGS-like) domain |
Function
for ARHGEF12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARHGC_HUMAN, Q9NZN5Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13(GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein(GAP) for GNA12 and GNA13
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ARHGEF12 (NM_001198665) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF12 |
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ARHGEF12 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for ARHGEF12:
Animal Models:
Mouse knock-out Arhgef12tm1Soff for ARHGEF12
5 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Arhgef12):
ARHGEF12 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ARHGEF12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/29 super-pathways (see all 29) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins | | | 3 | GPCR Pathway | | | 4 | Sema4D in semaphorin signaling | | | 5 | Signaling by GPCR | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 EMD Millipore Pathways for ARHGEF12
5/22 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGEF12 (see all 22)
5  GeneGo (Thomson Reuters) Pathways for ARHGEF12
1  BioSystems Pathway for ARHGEF12
5/15 
Reactome Pathways for ARHGEF12 (see all 15)
4 
Kegg Pathways (Kegg details for ARHGEF12):
ARHGEF12 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGEF12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/31 Interacting proteins for ARHGEF12 (Q9NZN52, 3 ENSP000003809424) via UniProtKB, MINT, STRING, and/or I2D (see all 31)About this table
Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9): About this table
ARHGEF12 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGEF12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ARHGEF12 for compounds About GeneDecksing
 Browse Tocris compounds for ARHGEF12
3 HMDB Compounds for ARHGEF12 About this table
6 Novoseek chemical compound relationships for ARHGEF12 gene About this table
Search CenterWatch for drugs/clinical trials and news about ARHGEF12 / ARHGC
|
Transcripts
for ARHGEF12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGEF12 gene (2 alternative transcripts): NM_001198665.1 NM_015313.2 Unigene Cluster for ARHGEF12: Rho guanine nucleotide exchange factor (GEF) 12 Hs.24598 [show with all ESTs]Unigene Representative Sequence: NM_01531313 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000397843(uc021qrm.1 uc001pxl.2 uc009zat.3 uc009zau.1)
ENST00000532993 ENST00000529970(uc010rzn.1) ENST00000530388 ENST00000528225
ENST00000525960 ENST00000532823 ENST00000525222 ENST00000530747 ENST00000531616
ENST00000526067 ENST00000528681 ENST00000356641
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF12
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ARHGEF12 (NM_001198665) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF12 |
Additional cDNA sequence: AB002380.2 AF090906.1 AF180681.1 AK294803.1 AK304316.1 AL080067.1 AL137456.1 BC016718.1 BC031784.1 BC063117.1 BX647785.1 BX648515.1 22 DOTS entries: DT.100735447 DT.453032 DT.100688036 DT.99937482 DT.70102520 DT.95153541 DT.95304734 DT.100688274 DT.75122045 DT.91683226 DT.120698640 DT.95196175 DT.95304729 DT.99999404 DT.100694644 DT.120698557 DT.40110111 DT.406771 DT.75155575 DT.91767532 DT.91767577 DT.120698572 24/371 AceView cDNA sequences (see all 371): AA779138 AF180681 AA907218 Z45421 AI383200 BG654675 BM090778 BU731795 F11453 AA459205 CB305981 BM982172 AI422244 BM707930 BP340780 AI762631 AI628156 BU630600 H69692 CB306555 AA370360 AW293491 AI640467 Z41132
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF12 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | - | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36 | ^ | 37 | ^ | 38 | ^ | 39 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARHGEF12
|
Expression
for ARHGEF12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGEF12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTTTACT
About this image
See ARHGEF12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGEF12
SOURCE GeneReport for Unigene cluster: Hs.24598
UniProtKB/Swiss-Prot: ARHGC_HUMAN, Q9NZN5Tissue specificity: Ubiquitously expressed. Isoform 2 is found in jejunum and testis
SABiosciences Custom PCR Arrays for ARHGEF12
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF12 |
Orthologs
for ARHGEF12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGEF12 gene from 6/20 species (see all 20) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ARHGEF121 |
Rho guanine nucleotide exchange factor (GEF) 12 |
72.81(n)
73.1(a) |
|
419752 XM_417890.3 XP_417890.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ARHGEF126 |
-- |
69(a) |
1 ↔ 1 |
LGa(1426352-1479725) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Larg2 |
guanine nucleotide exchange factor |
76.67(n) |
|
AY211396.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5624551 |
rho guanine nucleotide exchange factor 12-like |
59.64(n)
56.73(a) |
|
562455 XM_003200044.1 XP_003200092.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
RhoGEF23 |
gastrulation diacylglycerol binding |
37(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
F13E6.63 |
Tiam-1 like protein |
37(a) |
|
X(10733408-10738294) -- |
ENSEMBL Gene Tree for ARHGEF12 (if available)
TreeFam Gene Tree for ARHGEF12 (if available) |
Paralogs
for ARHGEF12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGEF12 gene
- ARHGEF22 ARHGEF32 ARHGEF112 NET12 ARHGEF12 ARHGEF182 AKAP132 ARHGEF282
4 SIMAP similar genes for ARHGEF12 using alignment to 2 protein entries: ARHGC_HUMAN (see all proteins):ARHGAP23 ARHGEF1 NET1 ARHGEF11
ARHGEF12 for paralogs About GeneDecksing
|
Genomic Variants
for ARHGEF12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGEF12 (120207787 - 120360645 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for ARHGEF12
8 Indels: 86059 75832 60066 86058 75831 86060 86056 86057
Human Gene Mutation Database (HGMD): ARHGEF12
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF12 |
|
Disorders
/ Diseases
for ARHGEF12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGEF12 for disorders About GeneDecksing
OMIM gene information: 604763
OMIM disorders: 601626
UniProtKB/Swiss-Prot: ARHGC_HUMAN, Q9NZN5
Note=A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocationt(11;11)(q23;23) with MLL
17  diseases for ARHGEF12: About MalaCardsacute myeloid leukemia leukemia myeloid leukemia shwachman-diamond syndrome
squamous cell carcinoma prostate cancer spasticity colorectal cancer
prostatitis cholesterol tuberculosis carcinoma
neuronitis breast and colorectal cancer breast cancer adenocarcinoma
pancreatitis
1 disease from the University of Copenhagen DISEASES database for ARHGEF12:Vascular disease 3 Novoseek disease relationships for ARHGEF12 gene About this table
Human Genome Epidemiology (HuGE) Navigator: ARHGEF12 (7 documents)
Export disorders for ARHGEF12 gene to outside databases
|
Publications
for ARHGEF12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGEF12 gene, integrated from 9 sources (see all 73):
(articles sorted by number of sources associating them with ARHGEF12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia. (PubMed id 10681437)1, 2, 3 Kourlas P.J....Caligiuri M.A. (2000)
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
- Direct interaction of insulin-like growth factor-1 receptor with leukemia-associated RhoGEF. (PubMed id 11724822)1, 2, 9 Taya S.... Kaibuchi K. (2001)
- Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. (PubMed id 12183458)1, 2, 9 Perrot V.... Gutkind J.S. (2002)
- Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor. (PubMed id 15331592)1, 2, 9 Kristelly R....Tesmer J.J. (2004)
- Conformational change upon ligand binding and dynamics of the PDZ domain from leukemia-associated Rho guanine nucleotide exchange factor. (PubMed id 18411422)1, 2, 9 Liu J....Shi Y. (2008)
- B plexins activate Rho through PDZ-RhoGEF. (PubMed id 12372594)1, 2 Driessens M.H.E.... Collard J.G. (2002)
- Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho. (PubMed id 11094164)1, 2 Fukuhara S.... Gutkind J.S. (2000)
- Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA. (PubMed id 11373293)1, 9 Reuther G.W....Der C.J. (2001)
- Genetic variants in the leukemia-associated Rho guanine nucleotide exchange factor (ARHGEF12) gene are not associated with T2DM and related parameters in Caucasians (KORA study). (PubMed id 17766704)1, 9 Holzapfel C....Illig T. (2007)
|
External Searches for ARHGEF12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing ARHGEF12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ARHGEF12 gene
(According to HUGE)
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Specialized Databases showing ARHGEF12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for ARHGEF12 gene:
Search GeneIP for patents involving ARHGEF12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ARHGEF12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARHGEF12 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF12 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARHGEF12 | | OriGene 3'-UTR Clone for ARHGEF12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARHGEF12 | | OriGene Custom Protein Services for ARHGEF12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGEF12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF12 |
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 | | | ARHGEF12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF12 |
|  |  |  | | | | Search ThermoFisher Antibodies for ARHGEF12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF12 |
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