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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGEF11 Gene

protein-coding   GIFtS: 67
GCID: GC01M156904

Rho Guanine Nucleotide Exchange Factor (GEF) 11

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 111 2     Rho Guanine Nucleotide Exchange Factor 112
GTRAP482     RhoA-Specific Guanine Nucleotide Exchange Factor2
PDZ-RHOGEF2     RhoGEF Glutamate Transport Modulator2
Glutamate Transporter EAAT4-Associated Protein 482     KIAA03803
Rho Guanine Exchange Factor (GEF) 112     PDZ-RhoGEF3

External Ids:    HGNC: 145801   Entrez Gene: 98262   Ensembl: ENSG000001326947   OMIM: 6057085   UniProtKB: O150853   

Export aliases for ARHGEF11 gene to outside databases

Previous GC identifers: GC01M154773 GC01M152669 GC01M153682 GC01M154122 GC01M154121 GC01M153717 GC01M155171 GC01M128263


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGEF11 Gene:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli
that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and
stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and
modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin
cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative
transcripts encoding different isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARHGEF11 Gene: 
ARHGEF11 (Rho guanine nucleotide exchange factor (GEF) 11) is a protein-coding gene. Diseases associated with ARHGEF11 include intracranial aneurysm, and gout, and among its related super-pathways are NRAGE signals death through JNK and Ras Pathway. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF2.

UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085
Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and
alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as
GTPase-activating protein (GAP) for GNA12 and GNA13

Gene Wiki entry for ARHGEF11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGEF11 gene promoter:
         NF-1   MyoD   MIF-1   C/EBPalpha   Meis-1b   POU2F1   POU2F1a   Meis-1a   Meis-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF11 promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGEF11

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21

ARHGEF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156904:  view genomic region     (about GC identifiers)

Start:
156,904,632 bp from pter      End:
157,015,162 bp from pter
Size:
110,531 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 11  
Size: 1522 amino acids; 167704 Da
Subunit: Interacts with GNA12 and GNA13 through the RGS domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts
with SLC1A6 (By similarity). Interacts (via DH domain) with GCSAM (via C-terminus)
Subcellular location: Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation
Sequence caution: Sequence=BAA20834.2; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for ARHGEF11:
1HTJ (3D)        1XCG (3D)        2DLS (3D)        3KZ1 (3D)        3T06 (3D)    
Secondary accessions: D3DVD0 Q5VY40 Q6PFW2
Alternative splicing: 2 isoforms:  O15085-1   O15085-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGEF11: NX_O15085

Explore proteomics data for ARHGEF11 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15085

  • ARHGEF11 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGEF11 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_055599.1  NP_937879.1  

    ENSEMBL proteins: 
     ENSP00000357177   ENSP00000354644   ENSP00000313470  
    Reactome Protein details: O15085
    Human Recombinant Protein Products for ARHGEF11: 
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    Cloud-Clone Corp. Proteins for ARHGEF11 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IC10026210
    GO:0005737cytoplasm IDA15755723
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    ARHGEF11 for ontologies           About GeneDecksing



    ARHGEF11 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ARHGEF: Rho guanine nucleotide exchange factors

    5/8 InterPro protein domains (see all 8):
     IPR015212 Regulat_G_prot_signal-like
     IPR001478 PDZ
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR000342 Regulat_G_prot_signal

    Graphical View of Domain Structure for InterPro Entry O15085

    ProtoNet protein and cluster: O15085

    4 Blocks protein domains:
    IPB000219 DH domain
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085
    Domain: The poly-Pro region is essential for plasma membrane localization upon stimulation
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 RGSL (RGS-like) domain


    ARHGEF11 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHGB_HUMAN, O15085
    Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and
    alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as
    GTPase-activating protein (GAP) for GNA12 and GNA13

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IDA15755723
    GO:0005089Rho guanyl-nucleotide exchange factor activity TAS10026210
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI10026210
    GO:0005543phospholipid binding IEA--
         
    ARHGEF11 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGEF11:
     Decreased focal adhesion (FA)   Decreased melanin production 

         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgef11):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     mortality/aging  nervous system  normal 

    ARHGEF11 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arhgef11tm1Sgkd for ARHGEF11

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGEF11 
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    SwitchGear 3'UTR luciferase reporter plasmidARHGEF11 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGEF11 About   (see all 25)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cell death signalling via NRAGE, NRIF and NADE
    Cell death signalling via NRAGE, NRIF and NADE0.74
    p75 NTR receptor-mediated signalling0.73
    NRAGE signals death through JNK0.74
    G alpha (12/13) signalling events0.46
    2GPCR Pathway
    Ras Pathway0.73
    Pancreatic Adenocarcinoma0.59
    GPCR Pathway0.62
    Breast Cancer Regulation by Stathmin10.58
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    4G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    Thrombin Signaling0.40
    G-AlphaI Signaling0.47
    5Sema4D in semaphorin signaling
    Sema4D in semaphorin signaling0.89
    Semaphorin interactions0.41
    Sema4D induced cell migration and growth-cone collapse0.89

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for ARHGEF11
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling G-Protein alpha-12 signaling pathway

    5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGEF11 (see all 21)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling

    2 GeneGo (Thomson Reuters) Pathways for ARHGEF11
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling G-Protein alpha-12 signaling pathway

    2 BioSystems Pathways for ARHGEF11
        Regulation of RhoA activity
    Signaling events mediated by focal adhesion kinase

    5/15        Reactome Pathways for ARHGEF11 (see all 15)
        GPCR downstream signaling
    Signaling by Rho GTPases
    Developmental Biology
    G alpha (12/13) signalling events
    Cell death signalling via NRAGE, NRIF and NADE


    1         Kegg Pathway  (Kegg details for ARHGEF11):
        Vascular smooth muscle contraction


    ARHGEF11 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGEF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/91 Interacting proteins for ARHGEF11 (O150851, 2, 3 ENSP000003571774) via UniProtKB, MINT, STRING, and/or I2D (see all 91)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615861, 2, 3, ENSP000004001754EBI-311099,EBI-446668 MINT-7949741 MINT-7949789 MINT-7949718 MINT-7949764 I2D: score=6 STRING: ENSP00000400175
    ABL1P005192, 3, ENSP000003614234MINT-8110045 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8110935 I2D: score=3 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8111703 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112387 I2D: score=3 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis NAS10026210
    GO:0001558regulation of cell growth NAS10026210
    GO:0006928cellular component movement NAS10026210
    GO:0006941striated muscle contraction NAS10026210
    GO:0007186G-protein coupled receptor signaling pathway TAS10026210

    ARHGEF11 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARHGEF11 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARHGEF11 (ARHGB)

    3 HMDB Compounds for ARHGEF11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    5 Novoseek inferred chemical compound relationships for ARHGEF11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 62.9 1 20018869 (1)
    gtp 55.2 3 20018869 (1)
    arginine 48 14 11799111 (3), 15488183 (2), 12024019 (2), 16652149 (2) (see all 9)
    tyrosine 13.5 4 11799111 (2), 15994438 (1), 15951850 (1)
    glutamate 0 2 11242047 (1)

    Search CenterWatch for drugs/clinical trials and news about ARHGEF11 / ARHGB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for ARHGEF11 gene (2 alternative transcripts): 
    NM_014784.3  NM_198236.2  

    Unigene Cluster for ARHGEF11:

    Rho guanine nucleotide exchange factor (GEF) 11
    Hs.516954  [show with all ESTs]
    Unigene Representative Sequence: BC057394
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368194(uc010phu.2 uc001fqn.3 uc001fqo.3) ENST00000487682
    ENST00000361409(uc001fqp.1) ENST00000492592 ENST00000461678 ENST00000486670
    ENST00000483682 ENST00000315174
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    Additional mRNA sequence: 

    AB002378.1 AK302500.1 AY429519.1 BC057394.1 

    10 DOTS entries:

    DT.100679834  DT.448275  DT.100780146  DT.92430892  DT.91910834  DT.95172157  DT.86856668  DT.121351608 
    DT.92063705  DT.95192968 

    24/194 AceView cDNA sequences (see all 194):

    BQ226186 AA780424 BQ228542 BU189777 CA308750 BM790752 BU181145 N21509 
    BQ230274 AI888287 BX374902 AW189021 CD369221 R59395 T17442 AL045761 
    AW204226 CA398135 AI251888 BF433634 CD626148 CA307096 AI824581 BQ942716 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF11 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                                  -                                                                                 
    SP2:                                                                                                  -                                 
    SP3:                                                                                                  -                                 
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ARHGEF11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGEF11 expression in normal human tissues (normalized intensities)      ARHGEF11 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAAGATTT
    ARHGEF11 Expression
    About this image


    ARHGEF11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/34 selected tissues (see all 34) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Uterus
             uterus, post-menopause ; glandular cells   

    See ARHGEF11 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGEF11

    SOURCE GeneReport for Unigene cluster: Hs.516954

    UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Array including ARHGEF11: 
              Cytoskeleton Regulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF11 gene from 7/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef111 , 5 Rho guanine nucleotide exchange factor (GEF) 111, 5 86.05(n)1
    86.24(a)1
      3 (38.22 cM)5
    2134981  NM_001003912.11  NP_001003912.11 
     876175595 
    chicken
    (Gallus gallus)
    Aves ARHGEF111 Rho guanine nucleotide exchange factor (GEF) 11 70.61(n)
    70.83(a)
      425979  XM_423659.3  XP_423659.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF116
    Uncharacterized protein
    66(a)
    1 ↔ 1
    GL343637.1(213186-260028)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.156612 Transcribed sequence with weak similarity to protein more 77.54(n)    BX746709.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgef111 Rho guanine nucleotide exchange factor (GEF) 11 56.51(n)
    52.31(a)
      565268  NM_001031840.1  NP_001027010.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGEF23 gastrulation diacylglycerol binding 37(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F13E6.63 Tiam-1 like protein 38(a)   X(10733408-10738294)   --


    ENSEMBL Gene Tree for ARHGEF11 (if available)
    TreeFam Gene Tree for ARHGEF11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGEF11 gene
    ARHGEF22  ARHGEF122  AKAP132  ARHGEF182  ARHGEF282  ARHGEF12  ENSG000002688612  
    3 SIMAP similar genes for ARHGEF11 using alignment to 2 protein entries:     ARHGB_HUMAN (see all proteins):
    ARHGEF1    ARHGAP23    ARHGEF12

    ARHGEF11 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2837 SNPs in ARHGEF11 are shown (see all 2837)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0242854
    ----see VAR_0242852 H R mis40--------
    VAR_0617954
    ----see VAR_0617952 S G mis40--------
    rs668408811,2
    C--128320770(-) TTAAA-/ATATATA 2 -- int11Minor allele frequency- AT:0.00NA 2
    rs42625351,2
    C--128374187(+) TTCCCG/ATCTCA 2 -- int13Minor allele frequency- A:0.00WA NA CSA 5
    rs1387375361,2
    C--128374406(+) GTGCCC/TCTGCC 2 -- int10--------
    rs106163861,2
    C--128374478(+) TCACCCT/-CTCTC 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs2012332531,2
    C--128374479(-) GAGAGA/GGGGTG 2 -- int10--------
    rs615215591,2
    C--128374483(+) CTCTC-/T/TC  
            
    CACCT
    2 -- int10--------
    rs721865791,2
    C--128374653(+) TTAAT-/AGCAGGCT 2 -- int10--------
    rs573890971,2
    C--128374655(+) AATAG-/CAGGCTGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for ARHGEF11 (156904632 - 157015162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARHGEF11:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv3099CNV Insertion18451855
    nsv3110CNV Insertion18451855
    nsv831659CNV Loss17160897
    esv275359CNV Gain+Loss21479260


    Human Gene Mutation Database (HGMD): ARHGEF11
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605708    OMIM disorders: --

    13 diseases for ARHGEF11:    About MalaCards
    intracranial aneurysm    gout    insulin resistance    diabetes mellitus
    squamous cell carcinoma    lung cancer    prostate cancer    adenocarcinoma
    prostatitis    pancreatitis    leukemia    breast cancer
    neuronitis


    ARHGEF11 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for ARHGEF11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12748184 (1)
    cancer 0 1 16691626 (1)

    Genetic Association Database (GAD): ARHGEF11
    Human Genome Epidemiology (HuGE) Navigator: ARHGEF11 (9 documents)

    Export disorders for ARHGEF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGEF11 gene, integrated from 9 sources (see all 89):
    (articles sorted by number of sources associating them with ARHGEF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member. (PubMed id 10526156)1, 2, 3 Ruemenapp U....Jakobs K.H. (1999)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
    3. Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. (PubMed id 11470431)1, 2, 9 Longenecker K.L....Derewenda Z.S. (2001)
    4. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. (PubMed id 12183458)1, 2, 9 Perrot V.... Gutkind J.S. (2002)
    5. A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. (PubMed id 16691626)1, 4, 9 Gu J....Berman D.M. (2006)
    6. Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish. (PubMed id 17369523)1, 4, 9 Fu M....Shuldiner A.R. (2007)
    7. Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians. (PubMed id 17287471)1, 4, 9 Ma L....Baier L.J. (2007)
    8. Genome-wide association study to identify genetic var iants present in Japanese patients harboring intracranial aneurysms. (PubMed id 20613766)1, 4 Akiyama K....Inoue I. (2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    10. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9826 HGNC: 14580 AceView: ARHGEF11 Ensembl:ENSG00000132694 euGenes: HUgn9826
    ECgene: ARHGEF11 Kegg: 9826 H-InvDB: ARHGEF11

    (According to HUGE)
    About This Section
    HUGE: KIAA0380

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGEF11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGEF11 gene:
    Search GeneIP for patents involving ARHGEF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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