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ARHGEF11 Gene

protein-coding   GIFtS: 61

GC01M156904
Rho guanine nucleotide exchange factor (GEF) 11
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for ARHGEF11 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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  User Feedback
Aliases & Descriptions
Rho guanine nucleotide exchange factor (GEF) 111 2     Rho guanine exchange factor (GEF) 112
KIAA03801 2 3     rho guanine nucleotide exchange factor 112
PDZ-RHOGEF1 2     glutamate transporter EAAT4-associated protein 482
GTRAP481 2     RhoA-specific guanine nucleotide exchange factor2
DKFZp667F12232     PDZ-RhoGEF3
RhoGEF glutamate transport modulator2     

External Ids:    HGNC: 145801   Entrez Gene: 98262   Ensembl: ENSG000001326947   UniProtKB: O150853   

Search outside databases for aliases for ARHGEF11 gene

Previous GC identifers: GC01M154773 GC01M152669 GC01M153682 GC01M154122 GC01M154121 GC01M153717 GC01M155171

Summaries
for ARHGEF11 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  User Feedback		 Entrez Gene summary for ARHGEF11:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that
work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate
Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate
transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its
overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding
different isoforms have been described. (provided by RefSeq)

UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085
Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13
(GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein
(GAP) for GNA12 and GNA13

Gene Wiki entry for ARHGEF11

Genomic Views
for ARHGEF11 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC and Ensembl (release 56), Regulatory elements and Epigenetics data according to SABiosciences)
About This Section

  User Feedback		 Regulatory elements:
"" SABiosciences Regulatory transcription factor binding sites in the ARHGEF11 gene upstream (promoter) region "":
Cdc5   HOXA9B   Meis-1   FAC1   RSRFC4   TGIF   MEF-2A   RORalpha2   STAT5A   Cart-1   

Epigenetics:
"" SABiosciences Methyl-Profiler DNA Methylation qPCR Primer Assays for ARHGEF11:  ""
MePH01814-1A   

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21

ARHGEF11 Gene in genomic location: bands according to Ensembl, locations according to "" (and/or Entrez Gene and/or Ensembl if different)
""

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156904:  view genomic region     (about GC identifiers)

Start:
 156,904,632 bp from pter
End:
 157,015,162 bp from pter
Size:
 110,531 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  

Proteins
for ARHGEF11 gene

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene, Novus Biologicals, and/or Sino Biological,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 May 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abnova, OriGene, Novus Biologicals, and/or Epitomics)
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  User Feedback		 UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 11  
Size: 1522 amino acids; 167704 Da
Subunit: Interacts with GNA12 and GNA13 through the RGS domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts with
SLC1A6 (By similarity)
Subcellular location: Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation
Sequence caution: Sequence=BAA20834.2; Type=Erroneous initiation;
PDB structures from "" and Proteopedia "" :
1HTJ (3D) ""    1XCG (3D) ""    2DLS (3D) ""    
Secondary accessions: Q5VY40

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_055599.1  NP_937879.1  


    ENSEMBL proteins: 
    ENSP00000357177 ENSP00000354644 ENSP00000414518 ENSP00000313470 


    Human Recombinant Proteins 
    ""Browse Purified and Recombinant Proteins at Millipore
    ""Browse Human Recombinant Proteins at Sigma-Aldrich
    "" Browse R&D Systems for human recombinant proteins
    ""Enzo Life Sciences proteins for ARHGEF11
    ""HuPro® and/or Recombinant Proteins from Abnova for ARHGEF11 ""
    ""Browse Origene full length recombinant human proteins expressed in human HEK293 cells
    ""Novus Biologicals Protein for ARHGEF11  ""
    ""Browse Sino Biological Recombinant Proteins  ""

    5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IC10026210
    GO:0005634 nucleus IDA18029348
    GO:0005730NOT nucleolus IDA18029348
    GO:0005737 cytoplasm IDA15755723 18029348
    GO:0005794 Golgi apparatus IDA18029348
    About this table

    "" ARHGEF11 for ontologies           About GeneDecksing



    Antibodies for ARHGEF11: 
    ""Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    ""Sigma-Aldrich Antibodies for ARHGEF11
    "" Browse R&D Systems for Antibodies
    ""Monoclonal and Polyclonal Antibodies from Abnova (ARHGEF11)
    ""Browse Origene Antibodies ""
    ""Novus Biologicals Antibodies for ARHGEF11
    ""Browse antibodies at Epitomics

    Assays for ARHGEF11: 
    ""Browse Kits and Assays available from Millipore
    ""Browse ELISAs at Sigma-Aldrich
    "" Browse R&D Systems for biochemical assays
    ""Enzo Life Sciences assays for ARHGEF11

    Protein Domains/
    Families
    for ARHGEF11 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

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    "" ARHGEF11 for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8 ):
     IPR015212 Regulat_G_prot_signal-like
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_type
     IPR015721 RhoGEF-like

    Graphical View of Domain Structure for InterPro Entry O15085

    ProtoNet protein and cluster: O15085

    4 Blocks protein families:
    IPB000219 DH domain
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085
    Domain: The poly-Pro region is essential for plasma membrane localization upon stimulation
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 RGSL (RGS-like) domain

    Gene Function
    for ARHGEF11 gene

    (According to MGI May 08 2010, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, Abnova, siRNAs from Applied Biosystems, Sigma-Aldrich, Clones from Millipore, Sigma-Aldrich, OriGene, Sino Biological, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene.)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (ARHGEF11)
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): ARHGEF11
    Origene shRNA RFP (see all 2): ARHGEF11
    Origene basic RS shRNA (see all 2): ARHGEF11

    ""Applied Biosystems Silencer® siRNAs for ARHGEF11
    ""Sigma-Aldrich siRNA for ARHGEF11
    Sigma-Aldrich shRNA for ARHGEF11
    Explore Sigma-Aldrich super-pooled esiRNAs
    Clones:""Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    ""Browse iPSC Reprogramming Factors at Sigma-Aldrich
    "" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): ARHGEF11
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ARHGEF11
    Origene untagged cDNA clones in CMV expression vector (see all 2): ARHGEF11
    ""Browse Sino Biological Human cDNA Clones  ""

    UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085
    Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13
    (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein
    (GAP) for GNA12 and GNA13

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664 G-protein-coupled receptor binding IDA15755723
    GO:0004871 signal transducer activity IEA--
    GO:0005085 guanyl-nucleotide exchange factor activity EXP11756498
    GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS10026210
    GO:0005096 GTPase activator activity IEA--
    About this table

    "" ARHGEF11 for ontologies           About GeneDecksing

    Pathways & Interactions
    for ARHGEF11 gene

    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, Applied Biosystems GeneAssist, KEGG and/or UniProtKB, (map by GeneGo),
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 May 2010 via Entrez Gene).
    About This Section

      User Feedback
    "" ARHGEF11 for pathways           About GeneDecksing

    2 "" Millipore Pathways for ARHGEF11
      ""  Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling G-Protein alpha-12 signaling pathway

    5/8 "" Sigma-Aldrich "Your Favorite Gene" Pathways for  ARHGEF11  (Your Favorite Gene powered by Ingenuity) (see all 8 )
      ""  Molecular Mechanisms of Cancer
    Phospholipase C Signaling
    Reelin Signaling in Neurons
    CXCR4 Signaling
    Axonal Guidance Signaling

    5/22 "" GeneAssist Pathways for ARHGEF11 (see all 22 )
      ""  NgR-p75(NTR)-Mediated Signaling
    Internalin Pathway
    MAPK Family Pathway
    G-AlphaI Signaling
    Interferon Pathway

    1 "" Kegg Pathway  (Kegg details for ARHGEF11):
      ""  hsa04270 Vascular smooth muscle contraction

    "" SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGEF11

    5/94 Interacting proteins for ARHGEF11 (ENSP000003571773 O150851, 2) via UniProtKB, MINT, and/or STRING (see all 94 ) ""
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCK1P163331, 2EBI-311099,EBI-389883 MINT-7248358 MINT-7250998 MINT-7250014 EBI-311099,EBI-389883 MINT-7248358 MINT-7250998 MINT-7250014
    CRKP461081, 2EBI-311099,EBI-886 MINT-7254058 MINT-7254864 EBI-311099,EBI-886 MINT-7254058 MINT-7254864
    ABL1P005191, 2EBI-311099,EBI-375543 MINT-7244302 EBI-311099,EBI-375543 MINT-7244302
    FYNP062411, 2EBI-311099,EBI-515315 MINT-7246402 EBI-311099,EBI-515315 MINT-7246402
    GRB2P629931, 2EBI-311099,EBI-401755 MINT-7253674 EBI-311099,EBI-401755 MINT-7253674
    About this table

    5/12 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 12 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910 cytokinesis NAS10026210
    GO:0001558 regulation of cell growth NAS10026210
    GO:0006915 apoptosis EXP12376548
    GO:0006928 cellular component movement NAS10026210
    GO:0006941 striated muscle contraction NAS10026210
    About this table

    "" ARHGEF11 for ontologies           About GeneDecksing


    Drugs & Compounds
    for ARHGEF11 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

      User Feedback
    "" ARHGEF11 for compounds           About GeneDecksing

    "" Enzo Life Sciences drugs & compounds for ARHGEF11
    ""Browse Small Molecules at Sigma-Aldrich

    "" Browse Tocris compounds for ARHGEF11
    10/11 ""Novoseek chemical compound relationships for ARHGEF11 gene (see all 11 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    l-arginine 28.29 18 12492428 (5), 12220504 (3), 11799111 (3), 15488183 (2) (see all 8)
    guanine 3.66 3 14625312 (2), 20093396 (1)
    fmlp 2.70 2 18086913 (2)
    axil 2.65 1 10517644 (1)
    actomyosin 1.43 1 18086913 (1)
    gdp 1.21 1 20018869 (1)
    tyrosine 0.93 3 11799111 (2), 15994438 (1)
    agarose 0.70 1 15976017 (1)
    gtp 0.70 1 20018869 (1)
    glutamate 0.18 1 11242047 (1)
    About this table


    Transcripts
    for ARHGEF11 gene

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 223 Homo sapiens; Apr 2 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Primers from OriGene and/or SABiosciences,
    Expression Assays from Applied Biosystems)
    About This Section

      User Feedback
    Inhib.
    RNA:    		""Browse for Gene Knock-down Tools from Millipore
    ""Abnova Chimera RNAi Products for Gene knock-down (ARHGEF11)
    ""Applied Biosystems Silencer® siRNAs:  NM_014784  NM_198236  
    "" Origene 29mer shRNA kits in GFP-retroviral vector (see all 2): ARHGEF11
    Origene shRNA RFP (see all 2): ARHGEF11
    Origene basic RS shRNA (see all 2): ARHGEF11

    ""Sigma-Aldrich siRNA for ARHGEF11
    Sigma-Aldrich shRNA for ARHGEF11
    Explore Sigma-Aldrich super-pooled esiRNAs

    microRNA:""10 SABiosciences microRNAs that regulate ARHGEF11: ""
    hsa-miR-128b hsa-miR-519d hsa-miR-20a hsa-miR-106a hsa-miR-106b hsa-miR-128 hsa-miR-132 hsa-miR-212 hsa-miR-20b hsa-miR-17
    Assays:  ""Applied Biosystems TaqMan® Gene Expression Assays:  
    NM_014784  NM_198236  


    Clones:"" Origene GFP tagged cDNA clones in CMV expression vector (see all 2): ARHGEF11
    Origene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): ARHGEF11
    Origene untagged cDNA clones in CMV expression vector (see all 2): ARHGEF11
    Primers:"" Origene genome-wide validated SYBR primer pairs: ARHGEF11
    ""SABiosciences RT2 qPCR Primer Assay for ARHGEF11: PPH18149A ""

    REFSEQ mRNAs for ARHGEF11 gene (2 alternative transcripts): 

    NM_014784.2  NM_198236.1  

    Additional cDNA sequence: 

    AB002378.1 AK302500.1 AL832790.1 AY429519.1 BC057394.1 

    10 DOTS entries:

    DT.100679834  DT.448275  DT.100780146  DT.92430892  DT.91910834  DT.95172157  DT.86856668  DT.92063705 
    DT.121351608  DT.95192968 

    24/194 AceView cDNA sequences (see all 194 ):

    BM790752 AL043722 AI824581 AI251888 CD626148 CB154669 AI243232 CD369221 
    CB306009 BQ231341 CA307096 AL045761 BU189777 AW189021 NM_198236 T17442 
    AW204226 BQ214196 NM_014784 AA780424 N21509 BQ226186 BU181145 BQ942716 

    "" highest scoring ESTs for ARHGEF11:

    AB002378 AA780424 BF081569 BM874166 BU194259 AA488128 AI090007 AI435351 AI910511 AI986387 

    Unigene Cluster for ARHGEF11:

    Rho guanine nucleotide exchange factor (GEF) 11
    Hs.516954  [show with all ESTs]
    Unigene Representative Sequence: BC057394


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF11 (see all 8 )

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                                  -                                                                                 
    SP2:                                                                                                  -                                 
    SP3:                                                                                                  -                                 
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    

    About this scheme

    ECgene alternative splicing isoforms for ARHGEF11

    9 Ensembl transcripts including schematic representations:
    ENST00000368194  ENST00000361409  ENST00000487682  ENST00000483682  ENST00000486670  ENST00000461678  
    ENST00000492592  ENST00000413909  ENST00000315174  

    Expression
    for ARHGEF11 gene

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 223 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems, Primers from OriGene and/or SABiosciences )
    About This Section

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    ARHGEF11 expression in normal and diseased human tissues

    "" Applied Biosystems TaqMan ® Gene Expression Assays for ARHGEF11

    1""  / 2""  / 3""

    6 probe-sets matching ARHGEF11 gene

    Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39281_at2, 3 U95-A 1 0.75 1.00 0.81 0.82 AB002378 1.00 0.87 0.94 1
    64412_at2, 3 U95-C 1 0.50 1.00 0.94 1.19 AI090007 0.60 1.00 0.82 1
    202914_s_at2, 3 U133-A 1 0.91 1.00 -- -- NM_014784 0.60 1.00 0.82 1
    202913_at2, 3 U133-A 1 0.46 1.00 -- -- AI090007 0.60 1.00 0.82 1
    202914_s_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    202913_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    About this table

    "" ARHGEF11 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GTTAAGATTT

    SOURCE GeneReport for Unigene cluster: Hs.516954

    Expression variation in blood from EXPOLDB for ARHGEF11

    UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085
    Tissue specificity: Ubiquitously expressed

    Primers:"" Origene genome-wide validated SYBR primer pairs: ARHGEF11 ""
    ""SABiosciences RT2 qPCR Primer Assay for ARHGEF11: PPH18149A ""

    Orthologs
    for ARHGEF11 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI May 08 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

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    Orthologs for ARHGEF11 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 ARHGEF111   -- Rho guanine nucleotide exchange factor (GEF) 11 86.24(n)
    88.29(a)    		 490402  XM_547523.2  XP_547523.2 
    chimpanzee
    (Pan troglodytes)    		 ARHGEF111   -- Rho guanine nucleotide exchange factor (GEF) 11 99.64(n)
    99.49(a)    		 457410  XM_513900.2  XP_513900.2 
    cow
    (Bos taurus)    		 ARHGEF111   -- Rho guanine nucleotide exchange factor (GEF) 11 87.89(n)
    89.11(a)    		 511220  XM_588515.3  XP_588515.3 
    rat
    (Rattus norvegicus)    		 Arhgef111   -- Rho guanine nucleotide exchange factor (GEF) 11 85.56(n)
    85.43(a)    		 78966  NM_023982.1  NP_076472.1 
    mouse
    (Mus musculus)    		 Arhgef111, 5 35
    		 Rho guanine nucleotide exchange factor (GEF) 111, 5 86.05(n)1
    86.24(a)1    		 2134981  NM_001003912.11  NP_001003912.11 
     AK0537585  AK0810425  (see all 15)
    About this table        Species with no ortholog for ARHGEF11

    ENSEMBL Gene Tree for ARHGEF11

    Paralogs
    for ARHGEF11 gene

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

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    Paralogs for ARHGEF11 gene
    ARHGEF22  ARHGEF122  ARHGEF182  AKAP132  ARHGEF12  RGNEF2  

    "" ARHGEF11 for paralogs           About GeneDecksing


    Genomic Variants
    for ARHGEF11 gene

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Genotyping Reagents from Applied Biosystems)
    About This Section

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    10/219 NCBI SNPs in ARHGEF11 are shown (see all 219 )
    (Click "" for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 234)
    ABGenomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    ""
    rs22751991,2
    		C,F,O,H156909695(+) CGCAGA/C/G/T 
                TTCTC     		8 K N mis1 ref1 syn1""11""EA NS NA WA 2258""
    ""
    rs38199731,2
    		C,F,A,H156905584(-) TCCCTT/CAGCCC 2 -- ut31 ese3 trp3""4Minor allele frequency- C:0.36NA EA WA 214""
    ""
    rs9455081,2
    		C,F,A,H156907081(-) CTTCCG/ATACCA 4 /H /R ref1 mis1 ese3""17Minor allele frequency- A:0.28MN NS EA NA WA 1312""
    ""
    rs31878781,2
    		C,F,A,H156904644(-) AAAGTT/CAAATA 2 -- ut31""7Minor allele frequency- C:0.26NS EA NA WA 622""
    ""
    rs66761,2
    		C,F,A156904818(-) ACTCTC/TCCTGA 2 -- ut31 ese3""7Minor allele frequency- T:0.38MN NS EA 878""
    ""
    rs8225721,2
    		C,F,A157014702(+) CTTTCG/AGCTGA 2 -- ut51 ese3""7Minor allele frequency- A:0.35EA NA WA 262""
    --
    rs38064211,2
    		C,F157014877(+) AAAAAA/TAAAAT 2 -- ut51""2Minor allele frequency- T:0.25NA EA 160""
    ""
    rs38064221,2
    		C,F157015026(+) CCCAGC/ACTGAT 2 -- ut51""7Minor allele frequency- A:0.36EA NS NA 1884""
    ""
    rs8224341,2
    		C,A128262528(+) TGGCTG/ACGTCT 2 -- ng31""4Minor allele frequency- A:0.04NS EA WA 348""
    --
    rs75478181,2
    		C,F128404968(+) gtctaC/Aacagt 2 -- ng51""8Minor allele frequency- A:0.03NS EA NA WA 472""
    About this table

    HapMap Linkage Disequilibrium images for ARHGEF11 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)  ""
          Database of Genomic Variants (DGV) variations for ARHGEF11: --

    Disorders & Mutations
    for ARHGEF11 gene

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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    "" ARHGEF11 for disorders           About GeneDecksing

    OMIM: 605708

    10/12 ""Novoseek disease relationships for ARHGEF11 gene (see all 12 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    gefs+ 5.20 2 16954208 (1), 15488183 (1)
    diabetes; type 2 3.67 6 17287471 (3), 18231709 (2), 17369523 (1)
    cell transformation 2.84 2 18445682 (2)
    glucose tolerance impaired 1.97 2 18231709 (2)
    hnscc 1.18 1 16565089 (1)
    insulin resistance 1.09 2 17287471 (2)
    hyperinsulinemia 0.81 1 17287471 (1)
    breast tumor 0.71 1 12748184 (1)
    squamous cell carcinoma 0.34 1 16565089 (1)
    lung cancer 0.23 1 16691626 (1)
    About this table

    Human Gene Mutation Database: ARHGEF11
    Human Genome Epidemiology Navigator: ARHGEF11 (5 documents)

    Medical News
    for ARHGEF11 gene

    (Possibly Related Articles in Doctor's Guide)
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    Publications
    for ARHGEF11 gene

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
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      User Feedback    		10/69 PubMed articles for ARHGEF11 gene (see all 69 ):

    Search for ARHGEF11 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
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    Genome Databases showing ARHGEF11 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9826 HGNC: 14580 AceView: ARHGEF11 Ensembl:ENSG00000132694 euGenes: HUgn9826
    ECgene: ARHGEF11 Kegg: 9826 H-InvDB: ARHGEF11

    Other Databases showing ARHGEF11 gene

    (According to HUGE)
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    HUGE: KIAA0380

    Specialized Databases showing ARHGEF11 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    Intellectual Property
    for ARHGEF11 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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      User Feedback    		Patent Information for ARHGEF11 gene: ""
    Search GeneIP for patents involving ARHGEF11

    GeneCards and IP: ""
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    Services
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    Clones available from OriGene, Sigma-Aldrich, Sino Biological, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience)
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    Products for ARHGEF11:
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    "" Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
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