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Aliases for ARHGEF11 Gene

Aliases for ARHGEF11 Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 11 2 3
  • PDZ-RHOGEF 3 4
  • Glutamate Transporter EAAT4-Associated Protein 48 3
  • RhoA-Specific Guanine Nucleotide Exchange Factor 3
  • Rho Guanine Nucleotide Exchange Factor 11 3
  • Rho Guanine Exchange Factor (GEF) 11 3
  • RhoGEF Glutamate Transport Modulator 3
  • KIAA0380 4
  • GTRAP48 3

External Ids for ARHGEF11 Gene

Summaries for ARHGEF11 Gene

Entrez Gene Summary for ARHGEF11 Gene

  • Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF11 Gene

ARHGEF11 (Rho Guanine Nucleotide Exchange Factor (GEF) 11) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and RhoGDI Pathway. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF2.

UniProtKB/Swiss-Prot for ARHGEF11 Gene

  • May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.

Gene Wiki entry for ARHGEF11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF11 Gene

Genomics for ARHGEF11 Gene

Genomic Location for ARHGEF11 Gene

156,934,840 bp from pter
157,046,558 bp from pter
111,719 bases
Minus strand

Genomic View for ARHGEF11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF11 Gene

Regulatory Elements for ARHGEF11 Gene

Proteins for ARHGEF11 Gene

  • Protein details for ARHGEF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 11
    Protein Accession:
    Secondary Accessions:
    • D3DVD0
    • Q5VY40
    • Q6PFW2

    Protein attributes for ARHGEF11 Gene

    1522 amino acids
    Molecular mass:
    167704 Da
    Quaternary structure:
    • Interacts with GNA12 and GNA13 through the RGS domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts with SLC1A6 (By similarity). Interacts (via DH domain) with GCSAM (via C-terminus).
    • Sequence=BAA20834.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGEF11 Gene

    Alternative splice isoforms for ARHGEF11 Gene


neXtProt entry for ARHGEF11 Gene

Proteomics data for ARHGEF11 Gene at MOPED

Post-translational modifications for ARHGEF11 Gene

  • Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14)
  • Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex when previously phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14), leading to its degradation, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF11 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF11 Gene

Domains for ARHGEF11 Gene

Gene Families for ARHGEF11 Gene

  • ARHGEF :Rho guanine nucleotide exchange factors


  • The poly-Pro region is essential for plasma membrane localization upon stimulation:
    • O15085
  • Contains 1 DH (DBL-homology) domain.:
    • O15085
  • Contains 1 PDZ (DHR) domain.:
    • O15085
  • Contains 1 PH domain.:
    • O15085
  • Contains 1 RGSL (RGS-like) domain.:
    • O15085
genes like me logo Genes that share domains with ARHGEF11: view

Function for ARHGEF11 Gene

Molecular function for ARHGEF11 Gene

UniProtKB/Swiss-Prot Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.

Gene Ontology (GO) - Molecular Function for ARHGEF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IDA 15755723
GO:0005089 Rho guanyl-nucleotide exchange factor activity TAS 10026210
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 10026210
genes like me logo Genes that share ontologies with ARHGEF11: view
genes like me logo Genes that share phenotypes with ARHGEF11: view

Animal Models for ARHGEF11 Gene

MGI Knock Outs for ARHGEF11:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGEF11 Gene

Localization for ARHGEF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF11 Gene

Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation.

Subcellular locations from

Jensen Localization Image for ARHGEF11 Gene COMPARTMENTS Subcellular localization image for ARHGEF11 gene
Compartment Confidence
cytosol 4
nucleus 3
golgi apparatus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for ARHGEF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IC 10026210
GO:0005737 cytoplasm IDA 15755723
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ARHGEF11: view

Pathways for ARHGEF11 Gene

genes like me logo Genes that share pathways with ARHGEF11: view

Gene Ontology (GO) - Biological Process for ARHGEF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis NAS 10026210
GO:0001558 regulation of cell growth NAS 10026210
GO:0006928 movement of cell or subcellular component NAS 10026210
GO:0006941 striated muscle contraction NAS 10026210
GO:0007186 G-protein coupled receptor signaling pathway TAS 10026210
genes like me logo Genes that share ontologies with ARHGEF11: view

Compounds for ARHGEF11 Gene

(3) HMDB Compounds for ARHGEF11 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
Guanosine monophosphate
  • 5'-GMP
Guanosine triphosphate
  • 5'-GTP

(5) Novoseek inferred chemical compound relationships for ARHGEF11 Gene

Compound -log(P) Hits PubMed IDs
gdp 62.9 1
gtp 55.2 1
arginine 48 14
tyrosine 13.5 4
glutamate 0 1
genes like me logo Genes that share compounds with ARHGEF11: view

Transcripts for ARHGEF11 Gene

Unigene Clusters for ARHGEF11 Gene

Rho guanine nucleotide exchange factor (GEF) 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2: -
SP3: -
SP8: - -

Relevant External Links for ARHGEF11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGEF11 Gene

mRNA expression in normal human tissues for ARHGEF11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGEF11 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF11 Gene Hs.516954

mRNA Expression by UniProt/SwissProt for ARHGEF11 Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with ARHGEF11: view

Orthologs for ARHGEF11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGEF11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia ARHGEF11 36
  • 99.64 (n)
  • 99.49 (a)
  • 99 (a)
(Bos Taurus)
Mammalia ARHGEF11 37
  • 89 (a)
LOC511220 36
  • 87.4 (n)
  • 88.48 (a)
(Canis familiaris)
Mammalia ARHGEF11 36
  • 86.25 (n)
  • 88.37 (a)
  • 87 (a)
(Mus musculus)
Mammalia Arhgef11 36
  • 85.87 (n)
  • 85.98 (a)
Arhgef11 16
Arhgef11 37
  • 86 (a)
(Monodelphis domestica)
Mammalia ARHGEF11 37
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 20 (a)
(Rattus norvegicus)
Mammalia Arhgef11 36
  • 84.78 (n)
  • 84.56 (a)
(Gallus gallus)
Aves ARHGEF11 36
  • 71.2 (n)
  • 70.91 (a)
  • 66 (a)
(Anolis carolinensis)
Reptilia ARHGEF11 37
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef11 36
  • 65 (n)
  • 64.79 (a)
Str.15661 36
(Danio rerio)
Actinopterygii arhgef11 36
arhgef11 37
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGEF2 37
  • 16 (a)
RhoGEF2 38
  • 37 (a)
(Caenorhabditis elegans)
Secernentea rhgf-1 37
  • 26 (a)
F13E6.6 38
  • 38 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROM1 37
  • 13 (a)
ROM2 37
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
Species with no ortholog for ARHGEF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF11 Gene

Gene Tree for ARHGEF11 (if available)
Gene Tree for ARHGEF11 (if available)

Paralogs for ARHGEF11 Gene

Selected SIMAP similar genes for ARHGEF11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARHGEF11: view

Variants for ARHGEF11 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs6676 -- 156,935,026(-) ACTCT(C/T)CCTGA utr-variant-3-prime
rs703152 -- 157,008,113(+) AACTC(A/G)AACTC intron-variant
rs716723 -- 157,015,150(+) CCTGG(A/T)CAATT intron-variant
rs716724 -- 157,015,058(+) CTCTC(A/G)TATTC intron-variant
rs822434 -- 156,934,365(+) TGGCT(A/G)CGTCT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF11 Gene

Variant ID Type Subtype PubMed ID
nsv831659 CNV Loss 17160897
nsv3099 CNV Insertion 18451855
nsv3110 CNV Insertion 18451855
esv275359 CNV Gain+Loss 21479260

Relevant External Links for ARHGEF11 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for ARHGEF11 Gene

(2) Novoseek inferred disease relationships for ARHGEF11 Gene

Disease -log(P) Hits PubMed IDs
tumors 0 1
cancer 0 1

Relevant External Links for ARHGEF11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with ARHGEF11: view

No data available for UniProtKB/Swiss-Prot for ARHGEF11 Gene

Publications for ARHGEF11 Gene

  1. Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. (PMID: 11470431) Longenecker K.L. … Derewenda Z.S. (Structure 2001) 3 4 23
  2. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. (PMID: 12183458) Perrot V. … Gutkind J.S. (J. Biol. Chem. 2002) 3 4 23
  3. A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. (PMID: 16691626) Gu J. … Berman D.M. (Cancer 2006) 3 23 49
  4. Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians. (PMID: 17287471) Ma L. … Baier L.J. (Diabetes 2007) 3 23 49
  5. Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish. (PMID: 17369523) Fu M. … Shuldiner A.R. (Diabetes 2007) 3 23 49

Products for ARHGEF11 Gene

Sources for ARHGEF11 Gene

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