ARHGEF11 Gene
protein-coding GIFtS: 63
GCID: GC01M156904
|
|
Rho guanine nucleotide exchange factor (GEF) 11
| |
Aliases
for ARHGEF11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho Guanine Nucleotide Exchange Factor (GEF) 111 2 | | Rho Guanine Exchange Factor (GEF) 112 | | GTRAP481 2 | | Rho Guanine Nucleotide Exchange Factor 112 | | PDZ-RHOGEF1 2 | | RhoA-Specific Guanine Nucleotide Exchange Factor2 | | KIAA03801 3 | | RhoGEF Glutamate Transport Modulator2 | | Glutamate Transporter EAAT4-Associated Protein 482 | | PDZ-RhoGEF3 |
Export aliases for ARHGEF11 gene to outside databasesPrevious GC identifers: GC01M154773 GC01M152669 GC01M153682 GC01M154122 GC01M154121 GC01M153717 GC01M155171 GC01M128263 |
Summaries
for ARHGEF11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARHGEF11:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli thatwork through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulateRho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamatetransport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and itsoverexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encodingdifferent isoforms have been described. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13(GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein(GAP) for GNA12 and GNA13
Gene Wiki entry for ARHGEF11
|
Genomic Views
for ARHGEF11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGEF11 gene promoter:
NF-1 MyoD MIF-1 C/EBPalpha Meis-1b POU2F1 POU2F1a Meis-1a Meis-1 ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGEF11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q21 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q21ARHGEF11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M156904: view genomic region
(about GC identifiers)
Start:
|
156,904,632 bp from pter |
End:
|
157,015,162 bp from pter |
Size:
|
110,531 bases |
Orientation:
|
minus strand |
|
Proteins
for ARHGEF11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085 (See
protein sequence)Recommended Name: Rho guanine nucleotide exchange factor 11 Size: 1522 amino acids; 167704 Da
Subunit: Interacts with GNA12 and GNA13 through the RGS domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts withSLC1A6 (By similarity). Interacts (via DH domain) with GCSAM (via C-terminus)
Subcellular location: Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation
Sequence caution: Sequence=BAA20834.2; Type=Erroneous initiation;
5 PDB 3D structures from  and Proteopedia  for ARHGEF11:1HTJ (3D)
1XCG (3D)
2DLS (3D)
3KZ1 (3D)
3T06 (3D)
Secondary accessions: D3DVD0 Q5VY40 Q6PFW2Alternative splicing: 2 isoforms: O15085-1 O15085-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARHGEF11: NX_O15085
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15085
ARHGEF11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_055599.1 NP_937879.1
ENSEMBL proteins: ENSP00000357177 ENSP00000354644 ENSP00000313470 Reactome Protein details: O15085
Human Recombinant Protein Products for ARHGEF11:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
ARHGEF11 for ontologies About GeneDecksing
ARHGEF11 Antibody Products:
Assay Products for ARHGEF11: |
Protein
Domains /
Families
for ARHGEF11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGEF11 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry O15085ProtoNet protein and cluster: O15085 4 Blocks protein families: IPB000219 DH domain IPB000342 Regulator of G-protein signalling (RGS) protein signature IPB001478 PDZ/DHR/GLGF domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085Domain: The poly-Pro region is essential for plasma membrane localization upon stimulationSimilarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 1 PDZ (DHR) domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 RGSL (RGS-like) domain |
Function
for ARHGEF11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: ARHGB_HUMAN, O15085Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13(GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein(GAP) for GNA12 and GNA13 Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
ARHGEF11 for ontologies About GeneDecksing
Phenotypes:
2 GenomeRNAi human phenotypes for ARHGEF11:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF11 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF11 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): ARHGEF11 (NM_198236) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF11 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF11 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF11 |
|
Pathways & Interactions
for ARHGEF11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/24 super-pathways (see all 24) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Cell death signalling via NRAGE, NRIF and NADE | | | 2 | GPCR Pathway | | | 3 | Sema4D in semaphorin signaling | | | 4 | Signaling by GPCR | | | 5 | G-AlphaQ Signaling | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 EMD Millipore Pathways for ARHGEF11
5/21 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGEF11 (see all 21)
2  GeneGo (Thomson Reuters) Pathways for ARHGEF11
2  BioSystems Pathways for ARHGEF11
5/15 
Reactome Pathways for ARHGEF11 (see all 15)
1 
Kegg Pathway (Kegg details for ARHGEF11):
ARHGEF11 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGEF11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/91 Interacting proteins for ARHGEF11 (O150851, 2, 3 ENSP000003571774) via UniProtKB, MINT, STRING, and/or I2D (see all 91)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RHOA | P615861, 2, 3, ENSP000004001754 | EBI-311099,EBI-446668 MINT-7949741 MINT-7949789 MINT-7949718 MINT-7949764 I2D:
score=6 STRING: ENSP00000400175 | | ABL1 | P005192, 3, ENSP000003614234 | MINT-8110045 I2D:
score=3 STRING: ENSP00000361423 | | FYN | P062412, 3, ENSP000003576564 | MINT-8110935 I2D:
score=3 STRING: ENSP00000357656 | | PIK3R1 | P279862, 3, ENSP000002743354 | MINT-8111703 I2D:
score=3 STRING: ENSP00000274335 | | PLCG1 | P191742, 3, ENSP000002440074 | MINT-8112387 I2D:
score=3 STRING: ENSP00000244007 |
About this table
Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table
ARHGEF11 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGEF11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ARHGEF11 for compounds About GeneDecksing
 Browse Tocris compounds for ARHGEF11
3 HMDB Compounds for ARHGEF11 About this table
5 Novoseek chemical compound relationships for ARHGEF11 gene About this table
Search CenterWatch for drugs/clinical trials and news about ARHGEF11 / ARHGB
|
Transcripts
for ARHGEF11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGEF11 gene (2 alternative transcripts): NM_014784.3 NM_198236.2 Unigene Cluster for ARHGEF11: Rho guanine nucleotide exchange factor (GEF) 11 Hs.516954 [show with all ESTs]Unigene Representative Sequence: BC0573948 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000368194(uc010phu.2 uc001fqn.3 uc001fqo.3) ENST00000487682
ENST00000361409(uc001fqp.1) ENST00000492592 ENST00000461678 ENST00000486670
ENST00000483682 ENST00000315174
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF11 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF11 (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): ARHGEF11 (NM_198236) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF11 |
Additional cDNA sequence: AB002378.1 AK302500.1 AY429519.1 BC057394.1 10 DOTS entries: DT.100679834 DT.448275 DT.100780146 DT.92430892 DT.91910834 DT.95172157 DT.86856668 DT.121351608 DT.92063705 DT.95192968 24/194 AceView cDNA sequences (see all 194): CD369221 BQ231341 CA307096 AL045761 BU189777 AW189021 NM_198236 T17442 AW204226 BQ718313 BM790752 CB306009 AL043722 AI243232 CB154669 AL119640 AI888287 CA398135 BF433634 BQ228542 BQ230274 BG955822 R59395 BX374902
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF11 (see all 8) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 | ^ | 17 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARHGEF11
|
Expression
for ARHGEF11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGEF11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTAAGATTT
About this image
See ARHGEF11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGEF11
SOURCE GeneReport for Unigene cluster: Hs.516954
UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085Tissue specificity: Ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Array including ARHGEF11:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF11
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF11 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF11 |
Orthologs
for ARHGEF11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGEF11 gene from 6/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ARHGEF111 |
Rho guanine nucleotide exchange factor (GEF) 11 |
70.61(n)
70.83(a) |
|
425979 XM_423659.3 XP_423659.3 |
lizard
(Anolis carolinensis) |
Reptilia |
ARHGEF116 |
-- |
65(a) |
1 ↔ 1 |
GL343637.1(213186-260028) |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
Str.156612 |
Transcribed sequence with weak similarity to protein more |
77.54(n) |
|
BX746709.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
arhgef111 |
Rho guanine nucleotide exchange factor (GEF) 11 |
56.51(n)
52.31(a) |
|
565268 NM_001031840.1 NP_001027010.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
RhoGEF23 |
gastrulation diacylglycerol binding |
37(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
F13E6.63 |
Tiam-1 like protein |
38(a) |
|
X(10733408-10738294) -- |
ENSEMBL Gene Tree for ARHGEF11 (if available)
TreeFam Gene Tree for ARHGEF11 (if available) |
Paralogs
for ARHGEF11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGEF11 gene
- ARHGEF22 ARHGEF32 NET12 ARHGEF12 ARHGEF122 ARHGEF182 AKAP132 ARHGEF282
3 SIMAP similar genes for ARHGEF11 using alignment to 2 protein entries: ARHGB_HUMAN (see all proteins):ARHGEF1 ARHGAP23 ARHGEF12
ARHGEF11 for paralogs About GeneDecksing
|
Genomic Variants
for ARHGEF11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGEF11 (156904632 - 157015162 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for ARHGEF11: --
Human Gene Mutation Database (HGMD): ARHGEF11
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF11 |
|
Disorders
/ Diseases
for ARHGEF11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGEF11 for disorders About GeneDecksing
OMIM gene information: 605708
OMIM disorders: --
16  diseases for ARHGEF11: About MalaCardstype 2 diabetes mellitus intracranial aneurysm diabetes mellitus insulin resistance
squamous cell carcinoma gout lung cancer prostate cancer
cholesterol prostatitis carcinoma leukemia
neuronitis breast cancer adenocarcinoma pancreatitis
2 Novoseek disease relationships for ARHGEF11 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
1 |
12748184 (1) |
| cancer |
0 |
1 |
16691626 (1) |
Human Genome Epidemiology (HuGE) Navigator: ARHGEF11 (9 documents)
Export disorders for ARHGEF11 gene to outside databases
|
Publications
for ARHGEF11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGEF11 gene, integrated from 9 sources (see all 86):
(articles sorted by number of sources associating them with ARHGEF11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member. (PubMed id 10526156)1, 2, 3 Ruemenapp U....Jakobs K.H. (1999)
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
- Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. (PubMed id 11470431)1, 2, 9 Longenecker K.L....Derewenda Z.S. (2001)
- Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. (PubMed id 12183458)1, 2, 9 Perrot V.... Gutkind J.S. (2002)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- B plexins activate Rho through PDZ-RhoGEF. (PubMed id 12372594)1, 2 Driessens M.H.E.... Collard J.G. (2002)
- Functions of a rho-specific guanine nucleotide exchange factor in neurite retraction. Possible role of a proline-rich motif of KIAA0380 in localization. (PubMed id 10900204)1, 2 Togashi H.... Inagaki M. (2000)
- A novel PDZ domain containing guanine nucleotide exchange factor links heterotrimeric G proteins to Rho. (PubMed id 10026210)1, 2 Fukuhara S.... Gutkind J.S. (1999)
- The amino acid motif L/IIxxFE defines a novel actin-b inding sequence in PDZ-RhoGEF. (PubMed id 19618964)1, 9 Banerjee J....Wedegaertner P.B. (2009)
|
External Searches for ARHGEF11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing ARHGEF11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing ARHGEF11 gene
(According to HUGE)
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Specialized Databases showing ARHGEF11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for ARHGEF11 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for ARHGEF11 gene:
Search GeneIP for patents involving ARHGEF11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ARHGEF11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARHGEF11 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF11 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF11 | | | OriGene Protein Over-expression Lysate for ARHGEF11 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARHGEF11 | | OriGene 3'-UTR Clone for ARHGEF11 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF11 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF11 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ARHGEF11 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARHGEF11 | | OriGene Custom Protein Services for ARHGEF11 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGEF11 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF11 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF11 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGEF11 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF11 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF11 |
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 | | | ARHGEF11 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF11 |
|  |  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF11 |
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