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Aliases for ARHGEF11 Gene

Aliases for ARHGEF11 Gene

  • Rho Guanine Nucleotide Exchange Factor 11 2 3 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 11 2 3
  • PDZ-RHOGEF 3 4
  • Glutamate Transporter EAAT4-Associated Protein 48 3
  • RhoA-Specific Guanine Nucleotide Exchange Factor 3
  • Rho Guanine Exchange Factor (GEF) 11 3
  • RhoGEF Glutamate Transport Modulator 3
  • KIAA0380 4
  • GTRAP48 3

External Ids for ARHGEF11 Gene

Previous GeneCards Identifiers for ARHGEF11 Gene

  • GC01M154773
  • GC01M152669
  • GC01M153682
  • GC01M154122
  • GC01M154121
  • GC01M153717
  • GC01M155171
  • GC01M128263

Summaries for ARHGEF11 Gene

Entrez Gene Summary for ARHGEF11 Gene

  • Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF11 Gene

ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and GPCR Pathway. GO annotations related to this gene include GTPase activator activity and G-protein coupled receptor binding. An important paralog of this gene is ARHGEF12.

UniProtKB/Swiss-Prot for ARHGEF11 Gene

  • May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.

Gene Wiki entry for ARHGEF11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF11 Gene

Genomics for ARHGEF11 Gene

Regulatory Elements for ARHGEF11 Gene

Enhancers for ARHGEF11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F157044 1 ENCODE 48.4 +0.6 562 3.0 SIN3A ZNF48 ZNF2 YY1 GLIS2 ELK1 SP5 REST KAT8 GLIS1 ARHGEF11 LRRC71 RN7SL612P GC01M156985
GH01F157074 0.9 Ensembl 46.5 -27.7 -27703 0.9 ELF3 HDAC1 ATF1 CREB3L1 INSM2 ARID4B ZNF48 ZNF2 RAD21 GLIS2 ARHGEF11 ETV3L KRT8P45
GH01F157089 1.1 Ensembl ENCODE 25.1 -43.8 -43832 1.4 ELF3 WRNIP1 KLF17 ARID4B ZNF2 RAD21 RARA ZNF143 DEK MIXL1 ARHGEF11 LRRC71 ETV3L KRT8P45
GH01F156991 0.7 ENCODE 29 +53.3 53330 2.7 HDAC1 CTCF PKNOX1 RAD21 SCRT2 NR2F6 SCRT1 USF2 ELF1 GABPA LRRC71 ARHGEF11 GC01M156985 RN7SL612P
GH01F156962 1 Ensembl ENCODE 18.6 +83.2 83240 2.4 PKNOX1 ZFHX2 ZNF157 POLR2A SCRT2 EGR2 SCRT1 USF2 ELF1 ZBTB7A LRRC71 ARHGEF11 PEAR1 MIR765 GC01M156985 RN7SL612P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGEF11 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGEF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000167023 1140 3001 SIN3A ZNF48 ZNF2 YY1 GLIS2 SP5 REST KAT8 GLIS1 ETV4

Genomic Location for ARHGEF11 Gene

Chromosome:
1
Start:
156,934,840 bp from pter
End:
157,046,640 bp from pter
Size:
111,801 bases
Orientation:
Minus strand

Genomic View for ARHGEF11 Gene

Genes around ARHGEF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF11 Gene

Proteins for ARHGEF11 Gene

  • Protein details for ARHGEF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15085-ARHGB_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 11
    Protein Accession:
    O15085
    Secondary Accessions:
    • D3DVD0
    • Q5VY40
    • Q6PFW2

    Protein attributes for ARHGEF11 Gene

    Size:
    1522 amino acids
    Molecular mass:
    167704 Da
    Quaternary structure:
    • Interacts with GNA12 and GNA13 through the RGS domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts with SLC1A6 (By similarity). Interacts (via DH domain) with GCSAM (via C-terminus).
    SequenceCaution:
    • Sequence=BAA20834.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGEF11 Gene

    Alternative splice isoforms for ARHGEF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF11 Gene

Post-translational modifications for ARHGEF11 Gene

  • Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14).
  • Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex when previously phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14), leading to its degradation, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for ARHGEF11 Gene

Domains & Families for ARHGEF11 Gene

Suggested Antigen Peptide Sequences for ARHGEF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15085

UniProtKB/Swiss-Prot:

ARHGB_HUMAN :
  • The poly-Pro region is essential for plasma membrane localization upon stimulation.
Domain:
  • The poly-Pro region is essential for plasma membrane localization upon stimulation.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 PH domain.
  • Contains 1 RGSL (RGS-like) domain.
genes like me logo Genes that share domains with ARHGEF11: view

Function for ARHGEF11 Gene

Molecular function for ARHGEF11 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.

Gene Ontology (GO) - Molecular Function for ARHGEF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G-protein coupled receptor binding IDA 15755723
GO:0005085 guanyl-nucleotide exchange factor activity IEA,TAS --
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA,TAS 10026210
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 10026210
genes like me logo Genes that share ontologies with ARHGEF11: view
genes like me logo Genes that share phenotypes with ARHGEF11: view

Animal Models for ARHGEF11 Gene

MGI Knock Outs for ARHGEF11:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGEF11 Gene

Localization for ARHGEF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF11 Gene

Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGEF11 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
cytoskeleton 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for ARHGEF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IC 10026210
GO:0005737 cytoplasm IEA,IDA 15755723
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with ARHGEF11: view

Pathways & Interactions for ARHGEF11 Gene

genes like me logo Genes that share pathways with ARHGEF11: view

Gene Ontology (GO) - Biological Process for ARHGEF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis NAS 10026210
GO:0001558 regulation of cell growth NAS 10026210
GO:0006928 movement of cell or subcellular component NAS 10026210
GO:0006941 striated muscle contraction NAS 10026210
GO:0007186 G-protein coupled receptor signaling pathway IEA,TAS 10026210
genes like me logo Genes that share ontologies with ARHGEF11: view

No data available for SIGNOR curated interactions for ARHGEF11 Gene

Drugs & Compounds for ARHGEF11 Gene

(5) Drugs for ARHGEF11 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for ARHGEF11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARHGEF11: view

Transcripts for ARHGEF11 Gene

Unigene Clusters for ARHGEF11 Gene

Rho guanine nucleotide exchange factor (GEF) 11:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: - -

Relevant External Links for ARHGEF11 Gene

GeneLoc Exon Structure for
ARHGEF11
ECgene alternative splicing isoforms for
ARHGEF11

Expression for ARHGEF11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF11 Gene

Protein differential expression in normal tissues from HIPED for ARHGEF11 Gene

This gene is overexpressed in Frontal cortex (6.9) and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGEF11 Gene



Protein tissue co-expression partners for ARHGEF11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF11 Gene:

ARHGEF11

SOURCE GeneReport for Unigene cluster for ARHGEF11 Gene:

Hs.516954

mRNA Expression by UniProt/SwissProt for ARHGEF11 Gene:

O15085-ARHGB_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ARHGEF11: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARHGEF11 Gene

Orthologs for ARHGEF11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGEF11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF11 34 35
  • 99.64 (n)
cow
(Bos Taurus)
Mammalia ARHGEF11 35
  • 89 (a)
OneToOne
LOC511220 34
  • 87.4 (n)
dog
(Canis familiaris)
Mammalia ARHGEF11 34 35
  • 86.25 (n)
mouse
(Mus musculus)
Mammalia Arhgef11 34 16 35
  • 85.87 (n)
rat
(Rattus norvegicus)
Mammalia Arhgef11 34
  • 84.78 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF11 35
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ARHGEF11 34 35
  • 71.2 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGEF11 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef11 34
  • 65 (n)
Str.15661 34
zebrafish
(Danio rerio)
Actinopterygii arhgef11 34 35
  • 47 (a)
fruit fly
(Drosophila melanogaster)
Insecta RhoGEF2 36 35
  • 37 (a)
worm
(Caenorhabditis elegans)
Secernentea F13E6.6 36
  • 38 (a)
rhgf-1 35
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROM1 35
  • 13 (a)
ManyToMany
ROM2 35
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
OneToMany
Species where no ortholog for ARHGEF11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF11 Gene

ENSEMBL:
Gene Tree for ARHGEF11 (if available)
TreeFam:
Gene Tree for ARHGEF11 (if available)

Paralogs for ARHGEF11 Gene

(3) SIMAP similar genes for ARHGEF11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARHGEF11: view

Variants for ARHGEF11 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1006168 -- 156,977,106(+) CAGCT(G/T)AGCTC intron-variant
rs1007604 -- 156,979,088(-) TAATC(G/T)TAACA intron-variant
rs10494306 -- 157,002,766(+) CATGA(C/T)GATAA intron-variant
rs10559382 -- 156,995,011(+) TTATC(-/TT)TGACA intron-variant
rs10580966 -- 157,007,927(+) TTTTT(-/T)GTCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF11 Gene

Variant ID Type Subtype PubMed ID
nsv831659 CNV loss 17160897
nsv3110 CNV insertion 18451855
nsv3099 CNV insertion 18451855
nsv1133914 CNV deletion 24896259
nsv1122410 CNV deletion 24896259
esv3890682 CNV loss 25118596
esv3587644 CNV loss 21293372
esv275359 CNV gain+loss 21479260

Variation tolerance for ARHGEF11 Gene

Residual Variation Intolerance Score: 5.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.39; 81.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF11 Gene

Human Gene Mutation Database (HGMD)
ARHGEF11
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF11 Gene

Disorders for ARHGEF11 Gene

Relevant External Links for ARHGEF11

Genetic Association Database (GAD)
ARHGEF11
Human Genome Epidemiology (HuGE) Navigator
ARHGEF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF11

No disorders were found for ARHGEF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF11 Gene

Publications for ARHGEF11 Gene

  1. Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish. (PMID: 17369523) Fu M. … Shuldiner A.R. (Diabetes 2007) 3 22 46 64
  2. Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians. (PMID: 17287471) Ma L. … Baier L.J. (Diabetes 2007) 3 22 46 64
  3. A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. (PMID: 16691626) Gu J. … Berman D.M. (Cancer 2006) 3 22 46 64
  4. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. (PMID: 12183458) Perrot V. … Gutkind J.S. (J. Biol. Chem. 2002) 3 4 22 64
  5. Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. (PMID: 11470431) Longenecker K.L. … Derewenda Z.S. (Structure 2001) 3 4 22 64

Products for ARHGEF11 Gene

Sources for ARHGEF11 Gene

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