Aliases for ARHGEF11 Gene
- Rho Guanine Nucleotide Exchange Factor (GEF) 11 2 3
- PDZ-RHOGEF 3 4
- Glutamate Transporter EAAT4-Associated Protein 48 3
- RhoA-Specific Guanine Nucleotide Exchange Factor 3
- Rho Guanine Nucleotide Exchange Factor 11 3
- Rho Guanine Exchange Factor (GEF) 11 3
- RhoGEF Glutamate Transport Modulator 3
- KIAA0380 4
- GTRAP48 3
External Ids for ARHGEF11 Gene
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGEF11 Gene
ARHGEF11 (Rho Guanine Nucleotide Exchange Factor (GEF) 11) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and RhoGDI Pathway. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF2.
UniProtKB/Swiss-Prot for ARHGEF11 Gene
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.