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Aliases for ARHGEF11 Gene

Aliases for ARHGEF11 Gene

  • Rho Guanine Nucleotide Exchange Factor 11 2 3 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 11 2 3
  • PDZ-RHOGEF 3 4
  • Glutamate Transporter EAAT4-Associated Protein 48 3
  • RhoA-Specific Guanine Nucleotide Exchange Factor 3
  • Rho Guanine Exchange Factor (GEF) 11 3
  • RhoGEF Glutamate Transport Modulator 3
  • KIAA0380 4
  • GTRAP48 3

External Ids for ARHGEF11 Gene

Previous GeneCards Identifiers for ARHGEF11 Gene

  • GC01M154773
  • GC01M152669
  • GC01M153682
  • GC01M154122
  • GC01M154121
  • GC01M153717
  • GC01M155171
  • GC01M128263

Summaries for ARHGEF11 Gene

Entrez Gene Summary for ARHGEF11 Gene

  • Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for ARHGEF11 Gene

ARHGEF11 (Rho Guanine Nucleotide Exchange Factor 11) is a Protein Coding gene. Among its related pathways are Semaphorin interactions and ERK Signaling. GO annotations related to this gene include GTPase activator activity and G-protein coupled receptor binding. An important paralog of this gene is ARHGEF12.

UniProtKB/Swiss-Prot for ARHGEF11 Gene

  • May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.

Gene Wiki entry for ARHGEF11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF11 Gene

Genomics for ARHGEF11 Gene

Regulatory Elements for ARHGEF11 Gene

Enhancers for ARHGEF11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGEF11 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGEF11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGEF11 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGEF11 Gene

Chromosome:
1
Start:
156,934,840 bp from pter
End:
157,046,640 bp from pter
Size:
111,801 bases
Orientation:
Minus strand

Genomic View for ARHGEF11 Gene

Genes around ARHGEF11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF11 Gene

Proteins for ARHGEF11 Gene

  • Protein details for ARHGEF11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15085-ARHGB_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 11
    Protein Accession:
    O15085
    Secondary Accessions:
    • D3DVD0
    • Q5VY40
    • Q6PFW2

    Protein attributes for ARHGEF11 Gene

    Size:
    1522 amino acids
    Molecular mass:
    167704 Da
    Quaternary structure:
    • Interacts with GNA12 and GNA13 through the RGS domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts with SLC1A6 (By similarity). Interacts (via DH domain) with GCSAM (via C-terminus).
    SequenceCaution:
    • Sequence=BAA20834.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARHGEF11 Gene

    Alternative splice isoforms for ARHGEF11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF11 Gene

Proteomics data for ARHGEF11 Gene at MOPED

Post-translational modifications for ARHGEF11 Gene

  • Phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14).
  • Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex when previously phosphorylated by MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14), leading to its degradation, thereby restricting RhoA activity and facilitating growth cone spreading and neurite outgrowth.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGEF11 Gene

Domains & Families for ARHGEF11 Gene

Suggested Antigen Peptide Sequences for ARHGEF11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15085

UniProtKB/Swiss-Prot:

ARHGB_HUMAN :
  • The poly-Pro region is essential for plasma membrane localization upon stimulation.
Domain:
  • The poly-Pro region is essential for plasma membrane localization upon stimulation.
  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 PDZ (DHR) domain.
  • Contains 1 PH domain.
  • Contains 1 RGSL (RGS-like) domain.
genes like me logo Genes that share domains with ARHGEF11: view

Function for ARHGEF11 Gene

Molecular function for ARHGEF11 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. Involved in neurotrophin-induced neurite outgrowth.

Gene Ontology (GO) - Molecular Function for ARHGEF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGEF11: view
genes like me logo Genes that share phenotypes with ARHGEF11: view

Animal Models for ARHGEF11 Gene

MGI Knock Outs for ARHGEF11:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGEF11 Gene

Localization for ARHGEF11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF11 Gene

Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF11 Gene COMPARTMENTS Subcellular localization image for ARHGEF11 gene
Compartment Confidence
cytosol 5
nucleus 4
plasma membrane 3
cytoskeleton 2
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for ARHGEF11 Gene

Pathways & Interactions for ARHGEF11 Gene

genes like me logo Genes that share pathways with ARHGEF11: view

Gene Ontology (GO) - Biological Process for ARHGEF11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000910 cytokinesis NAS 10026210
GO:0001558 regulation of cell growth NAS 10026210
GO:0006928 movement of cell or subcellular component NAS 10026210
GO:0006941 striated muscle contraction NAS 10026210
GO:0007186 G-protein coupled receptor signaling pathway TAS 10026210
genes like me logo Genes that share ontologies with ARHGEF11: view

No data available for SIGNOR curated interactions for ARHGEF11 Gene

Drugs & Compounds for ARHGEF11 Gene

(5) Drugs for ARHGEF11 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for ARHGEF11 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARHGEF11: view

Transcripts for ARHGEF11 Gene

Unigene Clusters for ARHGEF11 Gene

Rho guanine nucleotide exchange factor (GEF) 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF11 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
SP1: -
SP2: -
SP3: -
SP4:
SP5:
SP6:
SP7:
SP8: - -

Relevant External Links for ARHGEF11 Gene

GeneLoc Exon Structure for
ARHGEF11
ECgene alternative splicing isoforms for
ARHGEF11

Expression for ARHGEF11 Gene

mRNA expression in normal human tissues for ARHGEF11 Gene

Protein differential expression in normal tissues from HIPED for ARHGEF11 Gene

This gene is overexpressed in Frontal cortex (6.9) and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGEF11 Gene



SOURCE GeneReport for Unigene cluster for ARHGEF11 Gene Hs.516954

mRNA Expression by UniProt/SwissProt for ARHGEF11 Gene

O15085-ARHGB_HUMAN
Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with ARHGEF11: view

Protein tissue co-expression partners for ARHGEF11 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARHGEF11 Gene

Orthologs for ARHGEF11 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGEF11 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LOC511220 35
  • 87.4 (n)
  • 88.48 (a)
ARHGEF11 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF11 35
  • 86.25 (n)
  • 88.37 (a)
ARHGEF11 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef11 35
  • 85.87 (n)
  • 85.98 (a)
Arhgef11 16
Arhgef11 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF11 35
  • 99.64 (n)
  • 99.49 (a)
ARHGEF11 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef11 35
  • 84.78 (n)
  • 84.56 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGEF11 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 20 (a)
ManyToMany
chicken
(Gallus gallus)
Aves ARHGEF11 35
  • 71.2 (n)
  • 70.91 (a)
ARHGEF11 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF11 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef11 35
  • 65 (n)
  • 64.79 (a)
Str.15661 35
zebrafish
(Danio rerio)
Actinopterygii arhgef11 35
arhgef11 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGEF2 37
  • 37 (a)
RhoGEF2 36
  • 16 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F13E6.6 37
  • 38 (a)
rhgf-1 36
  • 26 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ROM1 36
  • 13 (a)
ManyToMany
ROM2 36
  • 12 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToMany
Species with no ortholog for ARHGEF11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGEF11 Gene

ENSEMBL:
Gene Tree for ARHGEF11 (if available)
TreeFam:
Gene Tree for ARHGEF11 (if available)

Paralogs for ARHGEF11 Gene

(3) SIMAP similar genes for ARHGEF11 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with ARHGEF11: view

Variants for ARHGEF11 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF11 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_024285 -
VAR_061795 -
rs703152 -- 157,008,113(+) AACTC(A/G)AACTC intron-variant
rs716723 -- 157,015,150(+) CCTGG(A/T)CAATT intron-variant
rs716724 -- 157,015,058(+) CTCTC(A/G)TATTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF11 Gene

Variant ID Type Subtype PubMed ID
nsv831659 CNV Loss 17160897
nsv3099 CNV Insertion 18451855
nsv3110 CNV Insertion 18451855
esv275359 CNV Gain+Loss 21479260

Variation tolerance for ARHGEF11 Gene

Residual Variation Intolerance Score: 5.34% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.39; 81.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF11 Gene

Human Gene Mutation Database (HGMD)
ARHGEF11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF11 Gene

Disorders for ARHGEF11 Gene

Relevant External Links for ARHGEF11

Genetic Association Database (GAD)
ARHGEF11
Human Genome Epidemiology (HuGE) Navigator
ARHGEF11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF11

No disorders were found for ARHGEF11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF11 Gene

Publications for ARHGEF11 Gene

  1. Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member. (PMID: 10526156) Ruemenapp U. … Jakobs K.H. (FEBS Lett. 1999) 2 3 4 67
  2. On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF. (PMID: 19460155) Zheng M. … Derewenda Z.S. (BMC Struct. Biol. 2009) 3 23
  3. The amino acid motif L/IIxxFE defines a novel actin-binding sequence in PDZ-RhoGEF. (PMID: 19618964) Banerjee J. … Wedegaertner P.B. (Biochemistry 2009) 3 23
  4. Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians. (PMID: 17287471) Ma L. … Baier L.J. (Diabetes 2007) 3 23
  5. Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish. (PMID: 17369523) Fu M. … Shuldiner A.R. (Diabetes 2007) 3 23

Products for ARHGEF11 Gene

Sources for ARHGEF11 Gene

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