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ARHGEF11 Gene

protein-coding   GIFtS: 66
GCID: GC01M156904

Rho Guanine Nucleotide Exchange Factor (GEF) 11

  Search for ARHGEF11
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 111 2     Rho Guanine Nucleotide Exchange Factor 112
GTRAP482     RhoA-Specific Guanine Nucleotide Exchange Factor2
PDZ-RHOGEF2     RhoGEF Glutamate Transport Modulator2
Glutamate Transporter EAAT4-Associated Protein 482     KIAA03803
Rho Guanine Exchange Factor (GEF) 112     PDZ-RhoGEF3

External Ids:    HGNC: 145801   Entrez Gene: 98262   Ensembl: ENSG000001326947   OMIM: 6057085   UniProtKB: O150853   

Export aliases for ARHGEF11 gene to outside databases

Previous GC identifers: GC01M154773 GC01M152669 GC01M153682 GC01M154122 GC01M154121 GC01M153717 GC01M155171 GC01M128263


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGEF11 Gene:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli
that work through G protein coupled receptors. The encoded protein may form a complex with G proteins and
stimulate Rho-dependent signals. A similar protein in rat interacts with glutamate transporter EAAT4 and
modulates its glutamate transport activity. Expression of the rat protein induces the reorganization of the actin
cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. Two alternative
transcripts encoding different isoforms have been described. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARHGEF11 Gene:
ARHGEF11 (Rho guanine nucleotide exchange factor (GEF) 11) is a protein-coding gene. GO annotations related to this gene include phospholipid binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF2.

UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085
Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and
alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as
GTPase-activating protein (GAP) for GNA12 and GNA13

Gene Wiki entry for ARHGEF11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGEF11 gene promoter:
         NF-1   MyoD   MIF-1   C/EBPalpha   Meis-1b   POU2F1   POU2F1a   Meis-1a   Meis-1   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF11 promoter sequence
   Search Chromatin IP Primers for ARHGEF11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q23.1   HGNC cytogenetic band: 1q21

ARHGEF11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF11 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M156904:  view genomic region     (about GC identifiers)

Start:
156,904,632 bp from pter      End:
157,015,162 bp from pter
Size:
110,531 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 11  
Size: 1522 amino acids; 167704 Da
Subunit: Interacts with GNA12 and GNA13 through the RGS domain. Interacts with RHOA, PLXNB1 and PLXNB2. Interacts
with SLC1A6 (By similarity). Interacts (via DH domain) with GCSAM (via C-terminus)
Sequence caution: Sequence=BAA20834.2; Type=Erroneous initiation;
5 PDB 3D structures from and Proteopedia for ARHGEF11:
1HTJ (3D)        1XCG (3D)        2DLS (3D)        3KZ1 (3D)        3T06 (3D)    
Secondary accessions: D3DVD0 Q5VY40 Q6PFW2
Alternative splicing: 2 isoforms:  O15085-1   O15085-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGEF11: NX_O15085

Explore proteomics data for ARHGEF11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGEF11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055599.1  NP_937879.1  

    ENSEMBL proteins: 
     ENSP00000357177   ENSP00000354644   ENSP00000313470  
    Reactome Protein details: O15085

    ARHGEF11 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ARHGEF11

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGEF: Rho guanine nucleotide exchange factors

    Selected InterPro protein domains (see all 7):
     IPR015212 RGS-like_dom
     IPR000219 DH-domain
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR015721 RhoGEF-like

    Graphical View of Domain Structure for InterPro Entry O15085

    ProtoNet protein and cluster: O15085

    4 Blocks protein domains:
    IPB000219 DH domain
    IPB000342 Regulator of G-protein signalling (RGS) protein signature
    IPB001478 PDZ/DHR/GLGF domain
    IPB001849 Pleckstrin-like


    UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085
    Domain: The poly-Pro region is essential for plasma membrane localization upon stimulation
    Similarity: Contains 1 DH (DBL-homology) domain
    Similarity: Contains 1 PDZ (DHR) domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 RGSL (RGS-like) domain


    Find genes that share domains with ARHGEF11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHGB_HUMAN, O15085
    Function: May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and
    alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as
    GTPase-activating protein (GAP) for GNA12 and GNA13

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001664G-protein coupled receptor binding IDA15755723
    GO:0005089Rho guanyl-nucleotide exchange factor activity TAS10026210
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI10026210
         
    Find genes that share ontologies with ARHGEF11           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGEF11:
     Decreased focal adhesion (FA)   Decreased melanin production 

         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Arhgef11):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     mortality/aging  nervous system  normal 

    Find genes that share phenotypes with ARHGEF11           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arhgef11tm1Sgkd for ARHGEF11

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF11
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGEF11

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGEF11
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGEF11

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF11 (see all 29):
    hsa-miR-323-3p hsa-miR-106a hsa-miR-128 hsa-miR-488 hsa-miR-132 hsa-miR-519a hsa-miR-93 hsa-miR-520g
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF11 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF11

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    GenScript: all cDNA clones in your preferred vector (see all 2): ARHGEF11 (NM_198236)
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF11


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARHGB_HUMAN, O15085: Cytoplasm. Membrane. Note=Translocated to the membrane upon stimulation
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    nucleus3
    golgi apparatus2
    plasma membrane2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IC10026210
    GO:0005737cytoplasm IDA15755723
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--

    Find genes that share ontologies with ARHGEF11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGEF11 About   (see all 25)  
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    NRAGE signals death through JNK0.71
    Cell death signalling via NRAGE, NRIF and NADE0.74
    G alpha (12/13) signalling events0.44
    2GPCR Pathway
    Ras Pathway0.73
    Pancreatic Adenocarcinoma0.59
    GPCR Pathway0.62
    Breast Cancer Regulation by Stathmin10.58
    3Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    4G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    Thrombin Signaling0.40
    G-AlphaI Signaling0.47
    5Semaphorin interactions
    Sema4D in semaphorin signaling0.90
    Semaphorin interactions0.43
    Sema4D induced cell migration and growth-cone collapse0.90


    Find genes that share SuperPaths with ARHGEF11           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGEF11 (see all 21)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling

    2 GeneGo (Thomson Reuters) Pathways for ARHGEF11
        Neurophysiological process Receptor-mediated axon growth repulsion
    G-protein signaling G-Protein alpha-12 signaling pathway

    2 BioSystems Pathways for ARHGEF11
        Regulation of RhoA activity
    Signaling events mediated by focal adhesion kinase

    4 Reactome Pathways for ARHGEF11
        Sema4D induced cell migration and growth-cone collapse
    G alpha (12/13) signalling events
    NRAGE signals death through JNK
    Rho GTPase cycle


    1 Kegg Pathway  (Kegg details for ARHGEF11):
        Vascular smooth muscle contraction

        Pathway & Disease-focused RT2 Profiler PCR Array including ARHGEF11: 
              Cytoskeleton Regulators in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARHGEF11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGEF11 (O150851, 2, 3 ENSP000003571774) via UniProtKB, MINT, STRING, and/or I2D (see all 98)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615861, 2, 3, ENSP000004001754EBI-311099,EBI-446668 MINT-7949741 MINT-7949789 MINT-7949718 MINT-7949764 I2D: score=6 STRING: ENSP00000400175
    ABL1P005192, 3, ENSP000003614234MINT-8110045 I2D: score=3 STRING: ENSP00000361423
    FYNP062412, 3, ENSP000003576564MINT-8110935 I2D: score=3 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8111703 I2D: score=3 STRING: ENSP00000274335
    PLCG1P191742, 3, ENSP000002440074MINT-8112387 I2D: score=3 STRING: ENSP00000244007
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis NAS10026210
    GO:0001558regulation of cell growth NAS10026210
    GO:0006928cellular component movement NAS10026210
    GO:0006941striated muscle contraction NAS10026210
    GO:0007186G-protein coupled receptor signaling pathway TAS10026210

    Find genes that share ontologies with ARHGEF11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGEF11 (ARHGB)

    3 HMDB Compounds for ARHGEF11    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    5 Novoseek inferred chemical compound relationships for ARHGEF11 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 62.9 1 20018869 (1)
    gtp 55.2 3 20018869 (1)
    arginine 48 14 11799111 (3), 15488183 (2), 12024019 (2), 16652149 (2) (see all 9)
    tyrosine 13.5 4 11799111 (2), 15994438 (1), 15951850 (1)
    glutamate 0 2 11242047 (1)



    Find genes that share compounds with ARHGEF11           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGEF11 gene (2 alternative transcripts): 
    NM_014784.3  NM_198236.2  

    Unigene Cluster for ARHGEF11:

    Rho guanine nucleotide exchange factor (GEF) 11
    Hs.516954  [show with all ESTs]
    Unigene Representative Sequence: BC057394
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368194(uc010phu.2 uc001fqn.3 uc001fqo.3) ENST00000487682
    ENST00000361409(uc001fqp.1) ENST00000492592 ENST00000461678 ENST00000486670
    ENST00000483682 ENST00000315174
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    hsa-miR-323-3p hsa-miR-106a hsa-miR-128 hsa-miR-488 hsa-miR-132 hsa-miR-519a hsa-miR-93 hsa-miR-520g
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      QuantiFast Probe-based Assays in human, mouse, rat ARHGEF11

    Additional mRNA sequence: 

    AB002378.1 AK302500.1 AY429519.1 BC057394.1 

    10 DOTS entries:

    DT.100679834  DT.448275  DT.100780146  DT.92430892  DT.91910834  DT.95172157  DT.86856668  DT.121351608 
    DT.92063705  DT.95192968 

    Selected AceView cDNA sequences (see all 194):

    BQ226186 CA308750 N21509 CB306009 CA398135 AW204226 NM_014784 AA780424 
    AI243232 BQ214196 BF433634 CA307096 AI251888 AB002378 AI824581 CB154669 
    AI888287 BU181145 BX374902 BQ231341 T17442 BQ230274 NM_198236 BQ942716 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF11 (see all 8)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17
    SP1:                                                  -                                                                                 
    SP2:                                                                                                  -                                 
    SP3:                                                                                                  -                                 
    SP4:                                                                                                                                    
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for ARHGEF11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGEF11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTAAGATTT
    ARHGEF11 Expression
    About this image


    ARHGEF11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ARHGEF11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGEF11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516954

    UniProtKB/Swiss-Prot: ARHGB_HUMAN, O15085
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including ARHGEF11: 
              Cytoskeleton Regulators in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGEF11 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef111 , 5 Rho guanine nucleotide exchange factor (GEF) 111, 5 85.87(n)1
    85.98(a)1
      3 (38.22 cM)5
    2134981  NM_001003912.11  NP_001003912.11 
     876175595 
    chicken
    (Gallus gallus)
    Aves ARHGEF111 Rho guanine nucleotide exchange factor (GEF) 11 71.2(n)
    70.91(a)
      425979  XM_423659.4  XP_423659.4 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF116
    Rho guanine nucleotide exchange factor (GEF) 11
    67(a)
    1 ↔ 1
    GL343637.1(213186-260028)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.156612 Transcribed sequence with weak similarity to protein more 77.54(n)    BX746709.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgef111 Rho guanine nucleotide exchange factor (GEF) 11   --   565268  NM_001031840.1  NP_001027010.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGEF23 gastrulation diacylglycerol binding 37(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea F13E6.63 Tiam-1 like protein 38(a)   X(10733408-10738294)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ROM16
    ROM26
    GDP/GTP exchange protein (GEP) for Rho1p; mutation...
    GDP/GTP exchange factor (GEF) for Rho1p and Rho2p;...
    13(a)
    12(a)
    many ↔ many
    many ↔ many
    VII(627806-631273) YGR070W
    XII(862714-866784) YLR371W


    ENSEMBL Gene Tree for ARHGEF11 (if available)
    TreeFam Gene Tree for ARHGEF11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGEF11 gene
    ARHGEF22  ARHGEF32  ARHGEF12  ENSG000002688612  NET12  ARHGEF122  AKAP132  ARHGEF182  
    ARHGEF282  
    3 SIMAP similar genes for ARHGEF11 using alignment to 2 protein entries:     ARHGB_HUMAN (see all proteins):
    ARHGEF1    ARHGAP23    ARHGEF12

    Find genes that share paralogs with ARHGEF11           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGEF11 (see all 2837)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs668408811,2
    C--128320770(-) TTAAA-/ATATATA 2 -- int11Minor allele frequency- AT:0.00NA 2
    rs42625351,2
    C--128374187(+) TTCCCG/ATCTCA 2 -- int13Minor allele frequency- A:0.00WA NA CSA 5
    rs1387375361,2
    C--128374406(+) GTGCCC/TCTGCC 2 -- int10--------
    rs106163861,2
    C--128374478(+) TCACCCT/-CTCTC 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs2012332531,2
    C--128374479(-) GAGAGA/GGGGTG 2 -- int10--------
    rs615215591,2
    C--128374483(+) CTCTC-/T/TC  
            
    CACCT
    2 -- int10--------
    rs721865791,2
    C--128374653(+) TTAAT-/AGCAGGCT 2 -- int10--------
    rs573890971,2
    C--128374655(+) AATAG-/CAGGCTGT 2 -- int10--------
    rs8610861,2
    C,F,A,H--128374665(+) TGTGTA/GAAGTG 2 -- int113Minor allele frequency- G:0.04NS EA NA CSA WA 787
    rs1493471381,2
    --128374772(+) CATTTA/GTCAGA 2 -- int10--------

    HapMap Linkage Disequilibrium report for ARHGEF11 (156904632 - 157015162 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for ARHGEF11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3099CNV Insertion18451855
    nsv3110CNV Insertion18451855
    nsv831659CNV Loss17160897
    esv275359CNV Gain+Loss21479260

    Human Gene Mutation Database (HGMD): ARHGEF11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGEF11
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605708    OMIM disorders: --


    Find genes that share disorders with ARHGEF11           About GenesLikeMe

    2 Novoseek inferred disease relationships for ARHGEF11 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 12748184 (1)
    cancer 0 1 16691626 (1)

    Genetic Association Database (GAD): ARHGEF11
    Human Genome Epidemiology (HuGE) Navigator: ARHGEF11 (9 documents)

    Export disorders for ARHGEF11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGEF11 gene, integrated from 10 sources (see all 90):
    (articles sorted by number of sources associating them with ARHGEF11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Rho-specific binding and guanine nucleotide exchange catalysis by KIAA0380, a dbl family member. (PubMed id 10526156)1, 2, 3 Ruemenapp U....Jakobs K.H. (FEBS Lett. 1999)
    2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    3. Structure of the RGS-like domain from PDZ-RhoGEF: linking heterotrimeric g protein-coupled signaling to Rho GTPases. (PubMed id 11470431)1, 2, 9 Longenecker K.L....Derewenda Z.S. (Structure 2001)
    4. Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF. (PubMed id 12183458)1, 2, 9 Perrot V.... Gutkind J.S. (J. Biol. Chem. 2002)
    5. A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. (PubMed id 16691626)1, 4, 9 Gu J....Berman D.M. (Cancer 2006)
    6. Evidence that Rho guanine nucleotide exchange factor 11 (ARHGEF11) on 1q21 is a type 2 diabetes susceptibility gene in the Old Order Amish. (PubMed id 17369523)1, 4, 9 Fu M....Shuldiner A.R. (Diabetes 2007)
    7. Variants in ARHGEF11, a candidate gene for the linkage to type 2 diabetes on chromosome 1q, are nominally associated with insulin resistance and type 2 diabetes in Pima Indians. (PubMed id 17287471)1, 4, 9 Ma L....Baier L.J. (Diabetes 2007)
    8. Genome-wide association study to identify genetic variants present in Japanese patients harboring intracranial aneurysms. (PubMed id 20613766)1, 4 Akiyama K....Inoue I. (J. Hum. Genet. 2010)
    9. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    10. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9826 HGNC: 14580 AceView: ARHGEF11 Ensembl:ENSG00000132694 euGenes: HUgn9826
    ECgene: ARHGEF11 Kegg: 9826 H-InvDB: ARHGEF11

    (According to HUGE)
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    HUGE: KIAA0380

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGEF11 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGEF11 gene:
    Search GeneIP for patents involving ARHGEF11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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