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Aliases for ARHGEF10L Gene

Aliases for ARHGEF10L Gene

  • Rho Guanine Nucleotide Exchange Factor (GEF) 10-Like 2 3
  • GrinchGEF 2 3 4 6
  • KIAA1626 4 6
  • Rho Guanine Nucleotide Exchange Factor 10-Like Protein 3

External Ids for ARHGEF10L Gene

Previous GeneCards Identifiers for ARHGEF10L Gene

  • GC01P017612
  • GC01P017738
  • GC01P017866
  • GC01P016112

Summaries for ARHGEF10L Gene

Entrez Gene Summary for ARHGEF10L Gene

  • ARHGEF10L is a member of the RhoGEF family of guanine nucleotide exchange factors (GEFs) that activate Rho GTPases (Winkler et al., 2005 [PubMed 16112081]).[supplied by OMIM, Dec 2008]

GeneCards Summary for ARHGEF10L Gene

ARHGEF10L (Rho Guanine Nucleotide Exchange Factor (GEF) 10-Like) is a Protein Coding gene. Among its related pathways are Regulation of RhoA activity and G-protein signaling_RhoB regulation pathway. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF10.

UniProtKB/Swiss-Prot for ARHGEF10L Gene

  • Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF10L Gene

Genomics for ARHGEF10L Gene

Regulatory Elements for ARHGEF10L Gene

Genomic Location for ARHGEF10L Gene

Start:
17,520,197 bp from pter
End:
17,697,875 bp from pter
Size:
177,679 bases
Orientation:
Plus strand

Genomic View for ARHGEF10L Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGEF10L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF10L Gene

Proteins for ARHGEF10L Gene

  • Protein details for ARHGEF10L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCE6-ARGAL_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 10-like protein
    Protein Accession:
    Q9HCE6
    Secondary Accessions:
    • B7ZKS1
    • Q17RW1
    • Q3YFJ4
    • Q5VXI5
    • Q5VXI6
    • Q66K51
    • Q6P0L7
    • Q8NAV5
    • Q9NVT3

    Protein attributes for ARHGEF10L Gene

    Size:
    1279 amino acids
    Molecular mass:
    140409 Da
    Quaternary structure:
    • Interacts with RHOA, RHOB and RHOC.
    SequenceCaution:
    • Sequence=BAA91663.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB13452.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC03792.1; Type=Erroneous termination; Positions=931; Note=Translated as Arg.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF10L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF10L Gene

Proteomics data for ARHGEF10L Gene at MOPED

Post-translational modifications for ARHGEF10L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF10L Gene

No data available for DME Specific Peptides for ARHGEF10L Gene

Domains for ARHGEF10L Gene

Gene Families for ARHGEF10L Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors

Protein Domains for ARHGEF10L Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCE6

UniProtKB/Swiss-Prot:

ARGAL_HUMAN :
  • Q9HCE6
Domain:
  • Contains 1 DH (DBL-homology) domain.
genes like me logo Genes that share domains with ARHGEF10L: view

Function for ARHGEF10L Gene

Molecular function for ARHGEF10L Gene

UniProtKB/Swiss-Prot Function: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.

Gene Ontology (GO) - Molecular Function for ARHGEF10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with ARHGEF10L: view

Animal Model Products

CRISPR Products

miRNA for ARHGEF10L Gene

miRTarBase miRNAs that target ARHGEF10L

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGEF10L

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for ARHGEF10L Gene

Localization for ARHGEF10L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF10L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF10L Gene COMPARTMENTS Subcellular localization image for ARHGEF10L gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ARHGEF10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with ARHGEF10L: view

Pathways for ARHGEF10L Gene

genes like me logo Genes that share pathways with ARHGEF10L: view

Pathways by source for ARHGEF10L Gene

1 BioSystems pathway for ARHGEF10L Gene
1 GeneGo (Thomson Reuters) pathway for ARHGEF10L Gene

Interacting Proteins for ARHGEF10L Gene

Gene Ontology (GO) - Biological Process for ARHGEF10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035023 regulation of Rho protein signal transduction --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGEF10L: view

Compounds for ARHGEF10L Gene

(3) HMDB Compounds for ARHGEF10L Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ARHGEF10L: view

Transcripts for ARHGEF10L Gene

Unigene Clusters for ARHGEF10L Gene

Rho guanine nucleotide exchange factor (GEF) 10-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGEF10L

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARHGEF10L
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF10L Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ARHGEF10L Gene

GeneLoc Exon Structure for
ARHGEF10L
ECgene alternative splicing isoforms for
ARHGEF10L

Expression for ARHGEF10L Gene

mRNA expression in normal human tissues for ARHGEF10L Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for ARHGEF10L Gene

SOURCE GeneReport for Unigene cluster for ARHGEF10L Gene Hs.443460

mRNA Expression by UniProt/SwissProt for ARHGEF10L Gene

Q9HCE6-ARGAL_HUMAN
Tissue specificity: Detected in heart, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with ARHGEF10L: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for ARHGEF10L Gene

Orthologs for ARHGEF10L Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF10L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF10L 35
  • 98.98 (n)
  • 99.19 (a)
ARHGEF10L 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGEF10L 35
  • 89.07 (n)
  • 89.69 (a)
ARHGEF10L 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGEF10L 35
  • 91.04 (n)
  • 94.03 (a)
ARHGEF10L 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgef10l 35
  • 86.84 (n)
  • 91.75 (a)
Arhgef10l 16
Arhgef10l 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF10L 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF10L 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgef10l 35
  • 85.19 (n)
  • 89.94 (a)
chicken
(Gallus gallus)
Aves ARHGEF10L 35
  • 76.52 (n)
  • 79.39 (a)
ARHGEF10L 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia ARHGEF10L 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12615 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef10l 35
  • 70.11 (n)
  • 71.88 (a)
Str.13733 35
zebrafish
(Danio rerio)
Actinopterygii ARHGEF10L (2 of 2) 36
  • 52 (a)
OneToMany
arhgef10lb 36
  • 55 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43658 36
  • 16 (a)
OneToMany
Species with no ortholog for ARHGEF10L:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF10L Gene

ENSEMBL:
Gene Tree for ARHGEF10L (if available)
TreeFam:
Gene Tree for ARHGEF10L (if available)

Paralogs for ARHGEF10L Gene

Paralogs for ARHGEF10L Gene

Selected SIMAP similar genes for ARHGEF10L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGEF10L: view

Variants for ARHGEF10L Gene

Sequence variations from dbSNP and Humsavar for ARHGEF10L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs725021 -- 17,626,036(-) AGGAG(G/T)ATGAA reference, synonymous-codon, nc-transcript-variant
rs744824 -- 17,602,435(+) ACTTA(C/T)GAAGT intron-variant
rs867984 -- 17,656,064(+) GCCAC(A/G)GTGCA synonymous-codon, reference, nc-transcript-variant
rs869526 -- 17,674,118(-) TTGCA(C/T)TGCAG intron-variant
rs871087 -- 17,691,027(+) TTTAT(C/T)GCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF10L Gene

Variant ID Type Subtype PubMed ID
nsv834302 CNV Loss 17160897
esv997027 OTHER Inversion 20482838
nsv818089 CNV Loss 17921354
nsv470701 CNV Loss 18288195
esv988531 CNV Deletion 20482838
nsv460673 CNV Loss 19166990
nsv870678 CNV Loss 21882294
nsv870973 CNV Loss 21882294
nsv4298 CNV Loss 18451855
esv2659798 CNV Deletion 23128226
nsv518693 CNV Loss 19592680
esv2744608 CNV Deletion 23290073
esv2661094 CNV Deletion 23128226
esv2744619 CNV Deletion 23290073
nsv512721 CNV Insertion 21212237

Relevant External Links for ARHGEF10L Gene

HapMap Linkage Disequilibrium report
ARHGEF10L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF10L Gene

Disorders for ARHGEF10L Gene

Relevant External Links for ARHGEF10L

Genetic Association Database (GAD)
ARHGEF10L
Human Genome Epidemiology (HuGE) Navigator
ARHGEF10L
genes like me logo Genes that share disorders with ARHGEF10L: view

No data available for UniProtKB/Swiss-Prot for ARHGEF10L Gene

Publications for ARHGEF10L Gene

  1. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4
  2. GrinchGEF -- a novel Rho-specific guanine nucleotide exchange factor. (PMID: 16112081) Winkler S. … Lutz S. (Biochem. Biophys. Res. Commun. 2005) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PMID: 18849993) Stacey S.N. … Stefansson K. (Nat. Genet. 2008) 3 48
  5. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 48

Products for ARHGEF10L Gene

Sources for ARHGEF10L Gene

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