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ARHGEF10L Gene

protein-coding   GIFtS: 59
GCID: GC01P017866

Rho Guanine Nucleotide Exchange Factor (GEF) 10-Like

  Search for ARHGEF10L
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 10-Like1 2
GrinchGEF1 2 3
GRINCHGEF3 5
KIAA16263 5
Rho Guanine Nucleotide Exchange Factor 10-Like Protein2

External Ids:    HGNC: 255401   Entrez Gene: 551602   Ensembl: ENSG000000749647   OMIM: 6124945   UniProtKB: Q9HCE63   

Export aliases for ARHGEF10L gene to outside databases

Previous GC identifers: GC01P017612 GC01P017738 GC01P016112


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGEF10L Gene:
ARHGEF10L is a member of the RhoGEF family of guanine nucleotide exchange factors (GEFs) that activate Rho GTPases
(Winkler et al., 2005 (PubMed 16112081)).(supplied by OMIM, Dec 2008)

GeneCards Summary for ARHGEF10L Gene:
ARHGEF10L (Rho guanine nucleotide exchange factor (GEF) 10-like) is a protein-coding gene. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is SPAG9.

UniProtKB/Swiss-Prot: ARGAL_HUMAN, Q9HCE6
Function: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGEF10L gene promoter:
         c-Fos   AP-1   RelA   Tal-1beta   HNF-1A   E47   GATA-1   HNF-1   SEF-1 (1)   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARHGEF10L promoter sequence
   Search Chromatin IP Primers for ARHGEF10L

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF10L


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p36.13   Ensembl cytogenetic band:  1p36.13   HGNC cytogenetic band: 1p36.13

ARHGEF10L Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF10L gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P017866:  view genomic region     (about GC identifiers)

Start:
17,866,330 bp from pter      End:
18,024,370 bp from pter
Size:
158,041 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARGAL_HUMAN, Q9HCE6 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 10-like protein  
Size: 1279 amino acids; 140409 Da
Subunit: Interacts with RHOA, RHOB and RHOC
Sequence caution: Sequence=BAA91663.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAB13452.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=BAC03792.1;
Type=Erroneous termination; Positions=931; Note=Translated as Arg;
Secondary accessions: B7ZKS1 Q17RW1 Q3YFJ4 Q5VXI5 Q5VXI6 Q66K51 Q6P0L7 Q8NAV5 Q9NVT3
Alternative splicing: 5 isoforms:  Q9HCE6-1   Q9HCE6-2   Q9HCE6-3   Q9HCE6-4   Q9HCE6-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGEF10L: NX_Q9HCE6

Explore proteomics data for ARHGEF10L at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGEF10L Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001011722.2  NP_060595.3  

    ENSEMBL proteins: 
     ENSP00000355060   ENSP00000364564   ENSP00000364557   ENSP00000399401   ENSP00000394621  
     ENSP00000364569   ENSP00000167825  

    ARHGEF10L Human Recombinant Protein Products:

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    Cloud-Clone Corp. ELISAs for ARHGEF10L
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGEF: Rho guanine nucleotide exchange factors

    3 InterPro protein domains:
     IPR000219 DH-domain
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry Q9HCE6

    ProtoNet protein and cluster: Q9HCE6

    1 Blocks protein domain: IPB000219 DH domain

    UniProtKB/Swiss-Prot: ARGAL_HUMAN, Q9HCE6
    Similarity: Contains 1 DH (DBL-homology) domain


    Find genes that share domains with ARHGEF10L           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARGAL_HUMAN, Q9HCE6
    Function: Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IEA--
    GO:0005100Rho GTPase activator activity ----
    GO:0005515protein binding ----
         
    Find genes that share ontologies with ARHGEF10L           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF10L
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    miRNA
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    miRTarBase miRNAs that target ARHGEF10L:
    hsa-mir-324-5p (MIRT043172)

    Block miRNA regulation of human, mouse, rat ARHGEF10L using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF10L (see all 11):
    hsa-miR-34b* hsa-miR-362-3p hsa-let-7a-2* hsa-miR-342-3p hsa-miR-329 hsa-let-7g* hsa-miR-129-5p hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF10L 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF10L


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    ARGAL_HUMAN, Q9HCE6: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0005829cytosol ----

    Find genes that share ontologies with ARHGEF10L           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGEF10L About    
    See pathways by source

    SuperPathContained pathways About
    1Regulation of RhoA activity
    Regulation of RhoA activity
    2G protein signaling RhoB regulation pathway
    G protein signaling RhoB regulation pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for ARHGEF10L
        G-protein signaling RhoB regulation pathway

    1 BioSystems Pathway for ARHGEF10L
        Regulation of RhoA activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGEF10L
    Interactions:

        Search GeneGlobe Interaction Network for ARHGEF10L

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGEF10L (Q9HCE62, 3 ENSP000003550604) via UniProtKB, MINT, STRING, and/or I2D (see all 34)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ANXA9O760272, 3, ENSP000003579434MINT-64952 I2D: score=4 STRING: ENSP00000357943
    DRAP1Q149192, 3MINT-64953 I2D: score=4 
    SCN2AQ992502, 3MINT-64955 I2D: score=3 
    NR4A1P227363, ENSP000002430504I2D: score=3 STRING: ENSP00000243050
    SCN1AP354983I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032321positive regulation of Rho GTPase activity ----
    GO:0032933SREBP signaling pathway ----
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0051496positive regulation of stress fiber assembly ----

    Find genes that share ontologies with ARHGEF10L           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGEF10L (ARGAL)

    3 HMDB Compounds for ARHGEF10L    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine monophosphate5'-GMP (see all 14)85-32-5--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGEF10L gene (2 alternative transcripts): 
    NM_001011722.2  NM_018125.3  

    Unigene Cluster for ARHGEF10L:

    Rho guanine nucleotide exchange factor (GEF) 10-like
    Hs.443460  [show with all ESTs]
    Unigene Representative Sequence: BC111058
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000361221(uc001ban.3) ENST00000375415 ENST00000482892 ENST00000469726(uc001baq.3)
    ENST00000375408(uc010ocs.2 uc001bar.3) ENST00000475356(uc009vpf.3)
    ENST00000482359 ENST00000466782 ENST00000495593(uc001bas.3) ENST00000452522(uc009vpe.1 uc001bao.3 uc001bap.3)
    ENST00000434513 ENST00000375420(uc010ocr.1) ENST00000167825
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF10L (see all 11):
    hsa-miR-34b* hsa-miR-362-3p hsa-let-7a-2* hsa-miR-342-3p hsa-miR-329 hsa-let-7g* hsa-miR-129-5p hsa-miR-377
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF10L 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): ARHGEF10L (NM_018125)
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGEF10L
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF10L
      QuantiFast Probe-based Assays in human, mouse, rat ARHGEF10L

    Additional mRNA sequence: 

    AB046846.1 AK001383.1 AK092020.1 AK126877.1 AK300174.1 AK300264.1 AK311076.1 BC003073.2 
    BC065561.1 BC080596.1 BC111058.1 BC115368.1 BC117171.1 BC143347.1 DQ139833.1 

    14 DOTS entries:

    DT.100758544  DT.101973046  DT.205454  DT.100758546  DT.121409662  DT.40295251  DT.95149222  DT.121409680 
    DT.100758545  DT.40294200  DT.91949327  DT.95192915  DT.91699872  DT.95136595 

    Selected AceView cDNA sequences (see all 134):

    CB068401 CA487411 BC029928 AI698350 Z44984 CA394245 CB528729 AI697019 
    BF447312 BQ945883 CO246708 CD679096 BU608323 F03939 CD675442 AI950680 
    BU154066 AI986388 BM745839 AK092020 BM126329 AK129959 CK818930 CN478990 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF10L (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^
    SP1:        -                                                     -           -                                                                 -               
    SP2:                                                        -     -           -                                                                 -               
    SP3:                                                                          -                                                                 -               
    SP4:                                                                                                  -     -     -     -                       -               
    SP5:                                                                                                                                            -               

    ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33
    SP1:              -     -     -                                                           -     -               
    SP2:              -     -     -                                                           -     -               
    SP3:              -     -     -                                                           -     -               
    SP4:              -     -     -                                                           -     -               
    SP5:              -     -     -                                                                 -               


    ECgene alternative splicing isoforms for ARHGEF10L

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGEF10L expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CGGGAGCCGG
    ARHGEF10L Expression
    About this image


    ARHGEF10L expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    ARHGEF10L Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGEF10L Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.443460

    UniProtKB/Swiss-Prot: ARGAL_HUMAN, Q9HCE6
    Tissue specificity: Detected in heart, liver, skeletal muscle, kidney and pancreas

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF10L

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF10L gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef10l1 , 5 Rho guanine nucleotide exchange factor (GEF) 10-like1, 5 86.84(n)1
    91.75(a)1
      4 (71.58 cM)5
    727541  NM_172415.31  NP_766003.31 
     1405144855 
    chicken
    (Gallus gallus)
    Aves ARHGEF10L1 Rho guanine nucleotide exchange factor (GEF) 10-like 76.52(n)
    79.39(a)
      419360  XM_003642508.2  XP_003642556.2 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF10L6
    Rho guanine nucleotide exchange factor (GEF) 10-li...
    86(a)
    1 ↔ 1
    AAWZ02040076(468-6902)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.126152 Xenopus laevis transcribed sequence with weak similarity more 77.36(n)    BJ071182.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgef10lb6
    ARHGEF10L (2 of 2)6
    Rho guanine nucleotide exchange factor (GEF) 10-li...
    Rho guanine nucleotide exchange factor (GEF) 10-li...
    55(a)
    52(a)
    1 ↔ many
    1 ↔ many
    23(21835130-21928792) ENSDARG00000074244
    11(30211398-30428820) ENSDARG00000088630
    fruit fly
    (Drosophila melanogaster)
    Insecta CG436586
    --
    16(a)
    1 → many
    X(17350590-17455214)


    ENSEMBL Gene Tree for ARHGEF10L (if available)
    TreeFam Gene Tree for ARHGEF10L (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGEF10L gene
    SPAG92  ARHGEF102  ARHGEF172  MAPK8IP32  
    1 SIMAP similar gene for ARHGEF10L using alignment to 3 protein entries:     ARGAL_HUMAN (see all proteins):
    ARHGEF10

    Find genes that share paralogs with ARHGEF10L           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGEF10L (see all 3524)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0441844
    A colorectal cancer sample4--see VAR_0441842 A V mis40--------
    rs106110231,2
    C--17864350(+) aaaaa-/A/A   
      AAAAAA
    aaaaa
    1 -- us2k12NA 4
    rs22451481,2
    C,F,A,H--17864514(-) AGCTCG/ACCGTA 1 -- us2k122Minor allele frequency- A:0.35NS EA NA CSA WA 2055
    rs2002533671,2
    --17864560(+) CTCTT-/AAAAAA 1 -- us2k10--------
    rs2014293071,2
    --17864571(+) AAAAC-/AAAG  
            
    AAAGA
    1 -- us2k10--------
    rs1813739141,2
    --17864574(+) ACAAAC/GAAAGA 1 -- us2k10--------
    rs1995234421,2
    --17864579(+) GAAAG-/AAAAAA 1 -- us2k10--------
    rs1856342031,2
    --17864590(+) AACATA/TGCCAA 1 -- us2k10--------
    rs757047151,2
    C,F--17864614(+) GTACAC/TTGTGA 1 -- us2k12Minor allele frequency- T:0.12CSA WA 119
    rs1405756641,2
    C--17864730(+) TCAATA/GGACAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGEF10L (17866330 - 18024370 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARHGEF10L (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744619CNV Deletion23290073
    esv2661094CNV Deletion23128226
    esv2744608CNV Deletion23290073
    esv2659798CNV Deletion23128226
    esv988531CNV Deletion20482838
    nsv512721CNV Insertion21212237
    nsv870678CNV Loss21882294
    nsv518693CNV Loss19592680
    nsv834302CNV Loss17160897
    nsv470701CNV Loss18288195

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGEF10L
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGEF10L

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 612494    OMIM disorders: --


    Find genes that share disorders with ARHGEF10L           About GenesLikeMe

    Genetic Association Database (GAD): ARHGEF10L
    Human Genome Epidemiology (HuGE) Navigator: ARHGEF10L (4 documents)

    Export disorders for ARHGEF10L gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGEF10L gene, integrated from 10 sources (see all 14):
    (articles sorted by number of sources associating them with ARHGEF10L)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. GrinchGEF -- a novel Rho-specific guanine nucleotide exchange factor. (PubMed id 16112081)1, 2, 3 Winkler S.... Lutz S. (Biochem. Biophys. Res. Commun. 2005)
    2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10997877)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PubMed id 19911011)1, 4 Takefuji M....Kaibuchi K. (J. Hum. Genet. 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PubMed id 18849993)1, 4 Stacey S.N....Stefansson K. (Nat. Genet. 2008)
    6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    7. Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy. (PubMed id 22095909)1 Lange C.M....Bochud P.Y. (Hepatology 2012)
    8. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (Science 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55160 HGNC: 25540 AceView: FLJ10521 Ensembl:ENSG00000074964 euGenes: HUgn55160
    ECgene: ARHGEF10L H-InvDB: ARHGEF10L

    (According to HUGE)
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    HUGE: KIAA1626

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARHGEF10L Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for ARHGEF10L Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGEF10L gene:
    Search GeneIP for patents involving ARHGEF10L

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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