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Aliases for ARHGEF10L Gene

Aliases for ARHGEF10L Gene

  • Rho Guanine Nucleotide Exchange Factor 10 Like 2 3 5
  • GrinchGEF 2 3 4
  • Rho Guanine Nucleotide Exchange Factor (GEF) 10-Like 2 3
  • Rho Guanine Nucleotide Exchange Factor 10-Like Protein 3
  • KIAA1626 4

External Ids for ARHGEF10L Gene

Previous GeneCards Identifiers for ARHGEF10L Gene

  • GC01P017612
  • GC01P017738
  • GC01P017866
  • GC01P016112

Summaries for ARHGEF10L Gene

Entrez Gene Summary for ARHGEF10L Gene

  • This gene belongs to the RhoGEF subfamily of RhoGTPases. Members of this subfamily are activated by specific guanine nucleotide exchange factors (GEFs) and are involved in signal transduction. The encoded protein shows cytosolic distribution. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2016]

GeneCards Summary for ARHGEF10L Gene

ARHGEF10L (Rho Guanine Nucleotide Exchange Factor 10 Like) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF10.

UniProtKB/Swiss-Prot for ARHGEF10L Gene

  • Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF10L Gene

Genomics for ARHGEF10L Gene

Regulatory Elements for ARHGEF10L Gene

Enhancers for ARHGEF10L Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F017572 0.9 Ensembl ENCODE 17.5 +54.3 54277 4.9 CTCF PKNOX1 CEBPG ZNF48 ZIC2 ZNF644 RAD21 RARA ZFHX2 GLIS2 ARHGEF10L GC01P017551 ACTL8
GH01F017585 1 Ensembl ENCODE 17 +67.6 67602 5.2 PKNOX1 MLX ARID4B DMAP1 ZNF48 YY1 FOS SP5 MXD4 REST ARHGEF10L GC01P017551 ACTL8
GH01F017567 1.5 FANTOM5 Ensembl ENCODE 12.1 +49.2 49171 4.1 TBP RAD21 ZNF366 GATA2 FOS SMARCA5 ZNF263 SMARCC1 ZNF280D ZBTB11 ARHGEF10L GC01P017551 ACTL8
GH01F017563 0.9 Ensembl ENCODE 12.1 +45.3 45304 3.4 ELF3 PKNOX1 MLX ARID4B DMAP1 ZSCAN9 GLIS2 SCRT2 EGR2 THAP11 ARHGEF10L GC01P017551 ACTL8
GH01F017579 0.7 ENCODE 11.8 +61.1 61108 3.4 MLX ARID4B DMAP1 ZNF48 YY1 SP5 MXD4 KAT8 MIER3 ETV4 ARHGEF10L GC01P017551 ACTL8
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around ARHGEF10L on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGEF10L Gene

Chromosome:
1
Start:
17,520,197 bp from pter
End:
17,697,875 bp from pter
Size:
177,679 bases
Orientation:
Plus strand

Genomic View for ARHGEF10L Gene

Genes around ARHGEF10L on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF10L Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF10L Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF10L Gene

Proteins for ARHGEF10L Gene

  • Protein details for ARHGEF10L Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HCE6-ARGAL_HUMAN
    Recommended name:
    Rho guanine nucleotide exchange factor 10-like protein
    Protein Accession:
    Q9HCE6
    Secondary Accessions:
    • B7ZKS1
    • Q17RW1
    • Q3YFJ4
    • Q5VXI5
    • Q5VXI6
    • Q66K51
    • Q6P0L7
    • Q8NAV5
    • Q9NVT3

    Protein attributes for ARHGEF10L Gene

    Size:
    1279 amino acids
    Molecular mass:
    140409 Da
    Quaternary structure:
    • Interacts with RHOA, RHOB and RHOC.
    SequenceCaution:
    • Sequence=BAA91663.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAB13452.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC03792.1; Type=Erroneous termination; Positions=931; Note=Translated as Arg.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF10L Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARHGEF10L Gene

Post-translational modifications for ARHGEF10L Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for ARHGEF10L Gene

Domains & Families for ARHGEF10L Gene

Gene Families for ARHGEF10L Gene

Protein Domains for ARHGEF10L Gene

Graphical View of Domain Structure for InterPro Entry

Q9HCE6

UniProtKB/Swiss-Prot:

ARGAL_HUMAN :
  • Contains 1 DH (DBL-homology) domain.
Domain:
  • Contains 1 DH (DBL-homology) domain.
genes like me logo Genes that share domains with ARHGEF10L: view

Function for ARHGEF10L Gene

Molecular function for ARHGEF10L Gene

UniProtKB/Swiss-Prot Function:
Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.

Gene Ontology (GO) - Molecular Function for ARHGEF10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
GO:0005096 GTPase activator activity IDA --
genes like me logo Genes that share ontologies with ARHGEF10L: view
genes like me logo Genes that share phenotypes with ARHGEF10L: view

Animal Model Products

miRNA for ARHGEF10L Gene

miRTarBase miRNAs that target ARHGEF10L

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF10L Gene

Localization for ARHGEF10L Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGEF10L Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGEF10L Gene COMPARTMENTS Subcellular localization image for ARHGEF10L gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for ARHGEF10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with ARHGEF10L: view

Pathways & Interactions for ARHGEF10L Gene

genes like me logo Genes that share pathways with ARHGEF10L: view

Pathways by source for ARHGEF10L Gene

Gene Ontology (GO) - Biological Process for ARHGEF10L Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032933 SREBP signaling pathway IDA --
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0043547 positive regulation of GTPase activity IEA --
GO:0051496 positive regulation of stress fiber assembly IDA --
genes like me logo Genes that share ontologies with ARHGEF10L: view

No data available for SIGNOR curated interactions for ARHGEF10L Gene

Drugs & Compounds for ARHGEF10L Gene

(3) Drugs for ARHGEF10L Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine monophosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGEF10L: view

Transcripts for ARHGEF10L Gene

Unigene Clusters for ARHGEF10L Gene

Rho guanine nucleotide exchange factor (GEF) 10-like:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF10L Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15a · 15b ^ 16a · 16b ^ 17 ^ 18 ^ 19a · 19b ^
SP1: - - - -
SP2: - - - -
SP3: - -
SP4: - - - - -
SP5: -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

ExUns: 20 ^ 21 ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 ^ 30 ^ 31 ^ 32a · 32b ^ 33
SP1: - - - - -
SP2: - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - -
SP6:
SP7:
SP8: -
SP9:
SP10:
SP11:
SP12:

Relevant External Links for ARHGEF10L Gene

GeneLoc Exon Structure for
ARHGEF10L
ECgene alternative splicing isoforms for
ARHGEF10L

Expression for ARHGEF10L Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGEF10L Gene

Protein differential expression in normal tissues from HIPED for ARHGEF10L Gene

This gene is overexpressed in Cervix (35.1), Urine (7.6), and Salivary gland (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for ARHGEF10L Gene



Protein tissue co-expression partners for ARHGEF10L Gene

NURSA nuclear receptor signaling pathways regulating expression of ARHGEF10L Gene:

ARHGEF10L

SOURCE GeneReport for Unigene cluster for ARHGEF10L Gene:

Hs.443460

mRNA Expression by UniProt/SwissProt for ARHGEF10L Gene:

Q9HCE6-ARGAL_HUMAN
Tissue specificity: Detected in heart, liver, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with ARHGEF10L: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for ARHGEF10L Gene

Orthologs for ARHGEF10L Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF10L Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGEF10L 34 35
  • 98.98 (n)
dog
(Canis familiaris)
Mammalia ARHGEF10L 34 35
  • 91.04 (n)
cow
(Bos Taurus)
Mammalia ARHGEF10L 34 35
  • 89.07 (n)
mouse
(Mus musculus)
Mammalia Arhgef10l 34 16 35
  • 86.84 (n)
rat
(Rattus norvegicus)
Mammalia Arhgef10l 34
  • 85.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGEF10L 35
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGEF10L 35
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGEF10L 34 35
  • 76.52 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGEF10L 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef10l 34
  • 70.11 (n)
Str.13733 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12615 34
zebrafish
(Danio rerio)
Actinopterygii arhgef10lb 35
  • 55 (a)
OneToMany
ARHGEF10L (2 of 2) 35
  • 52 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG43658 35
  • 16 (a)
OneToMany
Species where no ortholog for ARHGEF10L was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF10L Gene

ENSEMBL:
Gene Tree for ARHGEF10L (if available)
TreeFam:
Gene Tree for ARHGEF10L (if available)

Paralogs for ARHGEF10L Gene

Paralogs for ARHGEF10L Gene

(1) SIMAP similar genes for ARHGEF10L Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGEF10L: view

Variants for ARHGEF10L Gene

Sequence variations from dbSNP and Humsavar for ARHGEF10L Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_044184 A colorectal cancer sample
rs149908903 Likely pathogenic 17,697,186(+) CCGAC(G/T)ACCCC nc-transcript-variant, reference, missense
rs10047216 -- 17,557,352(+) aaaaa(A/C)aaaca intron-variant
rs10218654 -- 17,620,992(+) CTCGA(C/T)GGGGT intron-variant
rs10492992 -- 17,605,572(+) TTCAA(C/T)GGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF10L Gene

Variant ID Type Subtype PubMed ID
esv2659798 CNV deletion 23128226
esv2661094 CNV deletion 23128226
esv2764267 CNV loss 21179565
esv3351922 CNV duplication 20981092
esv3551122 CNV deletion 23714750
esv3585371 CNV loss 21293372
esv3585373 CNV loss 21293372
esv3585374 CNV loss 21293372
esv988531 CNV deletion 20482838
esv997027 OTHER inversion 20482838
nsv1160182 CNV duplication 26073780
nsv4298 CNV deletion 18451855
nsv460673 CNV loss 19166990
nsv470701 CNV loss 18288195
nsv512721 CNV insertion 21212237
nsv518693 CNV loss 19592680
nsv545710 CNV loss 21841781
nsv818089 CNV loss 17921354
nsv834302 CNV loss 17160897
nsv954872 CNV deletion 24416366

Variation tolerance for ARHGEF10L Gene

Residual Variation Intolerance Score: 12.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.42; 71.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF10L Gene

Human Gene Mutation Database (HGMD)
ARHGEF10L
SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGEF10L

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF10L Gene

Disorders for ARHGEF10L Gene

Relevant External Links for ARHGEF10L

Genetic Association Database (GAD)
ARHGEF10L
Human Genome Epidemiology (HuGE) Navigator
ARHGEF10L
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGEF10L

No disorders were found for ARHGEF10L Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGEF10L Gene

Publications for ARHGEF10L Gene

  1. GrinchGEF -- a novel Rho-specific guanine nucleotide exchange factor. (PMID: 16112081) Winkler S. … Lutz S. (Biochem. Biophys. Res. Commun. 2005) 2 3 4 64
  2. Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10997877) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 64
  3. Mutation of ARHGAP9 in patients with coronary spastic angina. (PMID: 19911011) Takefuji M. … Kaibuchi K. (J. Hum. Genet. 2010) 3 46 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits. (PMID: 18849993) Stacey S.N. … Stefansson K. (Nat. Genet. 2008) 3 46 64

Products for ARHGEF10L Gene

Sources for ARHGEF10L Gene

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