Aliases for ARHGEF10 Gene
External Ids for ARHGEF10 Gene
Previous GeneCards Identifiers for ARHGEF10 Gene
This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
GeneCards Summary for ARHGEF10 Gene
ARHGEF10 (Rho Guanine Nucleotide Exchange Factor 10) is a Protein Coding gene. Diseases associated with ARHGEF10 include slowed nerve conduction velocity, ad and cardioencephalomyopathy, fatal infantile, due to cytochrome c oxidase deficiency 3. Among its related pathways are ERK Signaling and Signaling by Slit. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and kinesin binding. An important paralog of this gene is ARHGEF10L.
UniProtKB/Swiss-Prot for ARHGEF10 Gene
May play a role in developmental myelination of peripheral nerves.