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ARHGEF10 Gene

protein-coding   GIFtS: 59
GCID: GC08P001778

Rho Guanine Nucleotide Exchange Factor (GEF) 10

  See ARHGEF10-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho Guanine Nucleotide Exchange Factor (GEF) 101 2
KIAA02943 5
GEF102
Rho Guanine Nucleotide Exchange Factor 102

External Ids:    HGNC: 141031   Entrez Gene: 96392   Ensembl: ENSG000001047287   OMIM: 6081365   UniProtKB: O150133   

Export aliases for ARHGEF10 gene to outside databases

Previous GC identifers: GC08M001714 GC08M002273 GC08P001922 GC08P001759 GC08P001586


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGEF10 Gene:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli
that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate
Rho-dependent signals. (provided by RefSeq, Jul 2008)

GeneCards Summary for ARHGEF10 Gene:
ARHGEF10 (Rho guanine nucleotide exchange factor (GEF) 10) is a protein-coding gene. Diseases associated with ARHGEF10 include slowed nerve conduction velocity, ad, and gastric dilatation. GO annotations related to this gene include kinesin binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is SPAG9.

UniProtKB/Swiss-Prot: ARHGA_HUMAN, O15013
Function: May play a role in developmental myelination of peripheral nerves

Gene Wiki entry for ARHGEF10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000008.10  NT_023736.18  NT_187576.1  NC_018919.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGEF10 gene promoter:
         ISGF-3   Nkx2-2   MIF-1   XBP-1   Nkx5-1   Max   N-Myc   Pax-4a   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGEF10 promoter sequence
   Search Chromatin IP Primers for ARHGEF10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGEF10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p23   Ensembl cytogenetic band:  8p23.3   HGNC cytogenetic band: 8p23

ARHGEF10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGEF10 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P001778:  view genomic region     (about GC identifiers)

Start:
1,772,142 bp from pter      End:
1,906,807 bp from pter
Size:
134,666 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: ARHGA_HUMAN, O15013 (See protein sequence)
Recommended Name: Rho guanine nucleotide exchange factor 10  
Size: 1369 amino acids; 151612 Da
Sequence caution: Sequence=AAH36809.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Sequence=AAH40474.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact; Sequence=BAA20754.2;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAH18365.1; Type=Erroneous
termination; Positions=895; Note=Translated as Lys;
Secondary accessions: O14665 Q2KHR8 Q68D55 Q8IWD9 Q8IY77
Alternative splicing: 5 isoforms:  O15013-1   O15013-6   O15013-7   O15013-4   O15013-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for ARHGEF10: NX_O15013

Explore proteomics data for ARHGEF10 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See ARHGEF10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055444.2  
    ENSEMBL proteins: 
     ENSP00000340297   ENSP00000427909   ENSP00000431012   ENSP00000427768   ENSP00000381571  
     ENSP00000262112   ENSP00000381568  

    ARHGEF10 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for ARHGEF10

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ARHGEF: Rho guanine nucleotide exchange factors

    3 InterPro protein domains:
     IPR000219 DH-domain
     IPR017986 WD40_repeat_dom
     IPR015943 WD40/YVTN_repeat-like_dom

    Graphical View of Domain Structure for InterPro Entry O15013

    ProtoNet protein and cluster: O15013

    1 Blocks protein domain: IPB000219 DH domain

    UniProtKB/Swiss-Prot: ARHGA_HUMAN, O15013
    Similarity: Contains 1 DH (DBL-homology) domain


    Find genes that share domains with ARHGEF10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ARHGA_HUMAN, O15013
    Function: May play a role in developmental myelination of peripheral nerves

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005089Rho guanyl-nucleotide exchange factor activity IDA16896804
    GO:0005515protein binding IPI19635168
    GO:0019894kinesin binding IPI19635168
         
    Find genes that share ontologies with ARHGEF10           About GenesLikeMe


    Phenotypes:
         1 MGI phenotypic allele for Arhgef10 (no phenotypes)

    Find genes that share phenotypes with ARHGEF10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arhgef10tm1(KOMP)Vlcg for ARHGEF10

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGEF10
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    miRNA
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    Block miRNA regulation of human, mouse, rat ARHGEF10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF10 (see all 38):
    hsa-miR-3607-3p hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-29a hsa-miR-25 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGEF10

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton4
    cytosol4
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005813centrosome IDA19635168
    GO:0005829cytosol NAS16896804

    Find genes that share ontologies with ARHGEF10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGEF10 About   (see all 15)  
    See pathways by source

    SuperPathContained pathways About
    1GPCR Pathway
    Ras Pathway0.73
    Pancreatic Adenocarcinoma0.59
    GPCR Pathway0.62
    Breast Cancer Regulation by Stathmin10.58
    2G-AlphaQ Signaling
    G-AlphaQ Signaling0.47
    Thrombin Signaling0.40
    G-AlphaI Signaling0.47
    3ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    4fMLP Pathway
    CXCR4 Pathway0.39
    Internalin Pathway0.31
    5CREB Pathway
    Activation of PKC through GPCR0.63

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGEF10 (see all 21)
        RhoA Pathway
    Guidance Cues and Growth Cone Motility
    Molecular Mechanisms of Cancer
    Interferon Pathway
    G-AlphaI Signaling

    1 BioSystems Pathway for ARHGEF10
        Regulation of RhoA activity


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGEF10
    Interactions:

        GeneGlobe Interaction Network for ARHGEF10

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for ARHGEF10 (O150131, 3 ENSP000003402974) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EHMT2Q96KQ73I2D: score=1 
    ENSG00000206376Q96KQ73I2D: score=1 
    ENSG00000227333Q96KQ73I2D: score=1 
    ENSG00000232045Q96KQ73I2D: score=1 
    ENSG00000236759Q96KQ73I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0022011myelination in peripheral nervous system IMP14508709
    GO:0032319regulation of Rho GTPase activity IDA16896804
    GO:0033126positive regulation of GTP catabolic process IDA16896804
    GO:0035023regulation of Rho protein signal transduction ----
    GO:0051298centrosome duplication IMP19635168

    Find genes that share ontologies with ARHGEF10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGEF10 (ARHGA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGEF10 gene: 
    NM_014629.2  

    Unigene Cluster for ARHGEF10:

    Rho guanine nucleotide exchange factor (GEF) 10
    Hs.98594  [show with all ESTs]
    Unigene Representative Sequence: CR749570
    16 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000349830(uc003wpr.3) ENST00000520359(uc003wps.3 uc010lre.3)
    ENST00000518288(uc003wpq.1) ENST00000382795 ENST00000520972(uc003wpt.3)
    ENST00000522969(uc010lrd.2 uc003wpu.3) ENST00000523711(uc003wpv.3)
    ENST00000522435 ENST00000524212 ENST00000519641 ENST00000523596 ENST00000523980
    ENST00000521927 ENST00000398564 ENST00000262112 ENST00000398560
    miRNA
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    Block miRNA regulation of human, mouse, rat ARHGEF10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGEF10 (see all 38):
    hsa-miR-3607-3p hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-29a hsa-miR-25 hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidARHGEF10 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF10
      QuantiFast Probe-based Assays in human, mouse, rat ARHGEF10

    Additional mRNA sequence: 

    AB002292.2 AF009205.1 AK309799.1 AL137508.1 BC026965.1 BC036809.1 BC040474.1 BC047307.1 
    BC112926.1 CR749570.1 

    11 DOTS entries:

    DT.114361  DT.100816211  DT.95164764  DT.65287948  DT.75113013  DT.95164761  DT.97811311  DT.97820408 
    DT.114362  DT.121489516  DT.99964675 

    Selected AceView cDNA sequences (see all 179):

    BU630774 CD514846 AW137967 N53385 BC040474 AI348138 AI367567 BU178611 
    AL042034 AU134444 AW873746 BQ882509 CR622006 BQ670124 AA400480 BU754567 
    CA439504 AB002292 BU153547 BM068727 AW302582 BQ018422 BQ945920 CA390972 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF10 (see all 18)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                      -                             -                                                                                       

    ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29
    SP1:                                                                                                                              
    SP2:                                                                                                                              
    SP3:                                                                                                                              
    SP4:                                                                                                                              
    SP5:                                                                                                                              


    ECgene alternative splicing isoforms for ARHGEF10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGEF10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAAAGTGAT
    ARHGEF10 Expression
    About this image


    ARHGEF10 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     Adipose (Muscoskeletal System)
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Mesenchymal Stem Cells
             Mesenchymal Stem Cells Subcutaneous White Adipose
     
     Thymus (Hematopoietic System)
    ARHGEF10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGEF10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.98594
        Custom PCR Arrays for ARHGEF10
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF10

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for ARHGEF10 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgef101 , 5 Rho guanine nucleotide exchange factor (GEF) 101, 5 79.14(n)1
    80.88(a)1
      8 (7.59 cM)5
    2340941  NM_172751.31  NP_766339.21 
     149116635 
    chicken
    (Gallus gallus)
    Aves ARHGEF101 Rho guanine nucleotide exchange factor (GEF) 10 72.5(n)
    76.66(a)
      421900  XM_001235642.3  XP_001235643.3 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGEF106
    Rho guanine nucleotide exchange factor (GEF) 10
    74(a)
    1 ↔ 1
    1(158595480-158708000)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.83772 Xenopus laevis transcribed sequence with weak similarity more 74.09(n)    48013129 
    zebrafish
    (Danio rerio)
    Actinopterygii 570444962   -- 72.39(n)    57044496 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG85573   -- 28(a)     --


    ENSEMBL Gene Tree for ARHGEF10 (if available)
    TreeFam Gene Tree for ARHGEF10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGEF10 gene
    SPAG92  ARHGEF172  ARHGEF10L2  MAPK8IP32  
    2 SIMAP similar genes for ARHGEF10 using alignment to 3 protein entries:     ARHGA_HUMAN (see all proteins):
    DKFZp761P221    ARHGEF10L

    Find genes that share paralogs with ARHGEF10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGEF10 (see all 4866)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0191184
    Slowed nerve conduction velocity (SNCV)4--see VAR_0191182 T I mis40--------
    rs747383751,2
    C,F--1770162(+) AACGAC/TAAAAA 1 -- us2k14Minor allele frequency- T:0.04CSA WA NA EA 360
    rs1132824371,2
    C,F--1770173(+) TAAAAC/TAGCTG 1 -- us2k13Minor allele frequency- T:0.03CSA WA NA 240
    rs1931616641,2
    --1770176(+) AACAGC/TTGATG 1 -- us2k10--------
    rs1132420561,2
    C--1770191(+) AGGCC-/ACGGTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs117772941,2
    C,F,H--1770256(+) aaggtG/Aaacct 1 -- us2k13Minor allele frequency- A:0.04WA NA EA 358
    rs70183361,2
    C,F--1770363(+) AGGAAC/TGCCTG 1 -- us2k1 tfbs35Minor allele frequency- T:0.09NA CSA WA EA 362
    rs1445726641,2
    --1770402(+) AGCTCA/CAAATC 1 -- us2k10--------
    rs111364271,2
    C,A,H--1770445(+) ATTGCT/CCTGTG 1 -- us2k14Minor allele frequency- C:0.04CSA WA NA EA 360
    rs111364281,2
    C,F,A,H--1770462(+) CTCAGT/CGGTGT 1 -- us2k122Minor allele frequency- C:0.05NS EA NA CSA WA 2746

    HapMap Linkage Disequilibrium report for ARHGEF10 (1772142 - 1906807 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARHGEF10 (see all 114):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2677306CNV Deletion23128226
    esv2736341CNV Deletion23290073
    esv2736331CNV Deletion23290073
    esv2736354CNV Deletion23290073
    esv2736327CNV Deletion23290073
    esv2736359CNV Deletion23290073
    esv2659595CNV Deletion23128226
    esv2660560CNV Deletion23128226
    esv2736358CNV Deletion23290073
    esv2516234CNV Deletion19546169

    Human Gene Mutation Database (HGMD): ARHGEF10
    Locus Specific Mutation Databases (LSDB): ARHGEF10

    Site Specific Mutation Identification with PCR Assays
    1 Copy Number PCR Panel containing ARHGEF10:
    Pancreatic Cancer
    SeqTarget long-range PCR primers for resequencing ARHGEF10
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGEF10

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608136   
    OMIM disorders: 608236  
    UniProtKB/Swiss-Prot: ARHGA_HUMAN, O15013
  • Slowed nerve conduction velocity (SNCV) [MIM:608236]: Affected individuals present a reduction in nerve
    conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV
    inheritance is autosomal dominant. Note=The disease is caused by mutations affecting the gene represented in this
    entry

  • 2 diseases for ARHGEF10:    
    About MalaCards
    slowed nerve conduction velocity, ad    gastric dilatation


    Find genes that share disorders with ARHGEF10           About GenesLikeMe

    Genetic Association Database (GAD): ARHGEF10
    Human Genome Epidemiology (HuGE) Navigator: ARHGEF10 (4 documents)

    Export disorders for ARHGEF10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGEF10 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with ARHGEF10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 1997)
    2. Functional SNP of ARHGEF10 confers risk of atherothrombotic stroke. (PubMed id 20042462)1, 4 Matsushita T....Kubo M. (Hum. Mol. Genet. 2010)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. An association screen of myelin-related genes implicates the chromosome 22q11 PIK4CA gene in schizophrenia. (PubMed id 17893707)1, 4 Jungerius B.J....Sinke R.J. (Mol. Psychiatry 2008)
    5. Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture. (PubMed id 16896804)1, 3 Mohl M....Lutz S. (Naunyn Schmiedebergs Arch. Pharmacol. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Slowed conduction and thin myelination of peripheral nerves associated with mutant rho Guanine-nucleotide exchange factor 10. (PubMed id 14508709)1, 2 Verhoeven K.... Timmerman V. (Am. J. Hum. Genet. 2003)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    9. High-resolution mapping and transcript identification at the progressive epilepsy with mental retardation locus on chromosome 8p. (PubMed id 9314494)1, 2 Ranta S....Gilliam T.C. (Genome Res. 1997)
    10. A genome-wide association study of brain lesion distribution in multiple sclerosis. (PubMed id 23412934)1 Gourraud P.A....Baranzini S.E. (Brain 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9639 HGNC: 14103 AceView: ARHGEF10 Ensembl:ENSG00000104728 euGenes: HUgn9639
    ECgene: ARHGEF10 H-InvDB: ARHGEF10

    (According to HUGE)
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    HUGE: KIAA0294

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGEF10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGEF10 gene:
    Search GeneIP for patents involving ARHGEF10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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