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Aliases for ARHGEF10 Gene

Aliases for ARHGEF10 Gene

  • Rho Guanine Nucleotide Exchange Factor 10 2 3 5
  • Rho Guanine Nucleotide Exchange Factor (GEF) 10 2 3
  • KIAA0294 4
  • GEF10 3
  • SNCV 3

External Ids for ARHGEF10 Gene

Previous GeneCards Identifiers for ARHGEF10 Gene

  • GC08M001714
  • GC08M002273
  • GC08P001922
  • GC08P001759
  • GC08P001778
  • GC08P001586

Summaries for ARHGEF10 Gene

Entrez Gene Summary for ARHGEF10 Gene

  • This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for ARHGEF10 Gene

ARHGEF10 (Rho Guanine Nucleotide Exchange Factor 10) is a Protein Coding gene. Diseases associated with ARHGEF10 include Slowed Nerve Conduction Velocity, Ad. Among its related pathways are ERK Signaling and GPCR Pathway. GO annotations related to this gene include Rho guanyl-nucleotide exchange factor activity and kinesin binding. An important paralog of this gene is ARHGEF10L.

UniProtKB/Swiss-Prot for ARHGEF10 Gene

  • May play a role in developmental myelination of peripheral nerves.

Gene Wiki entry for ARHGEF10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGEF10 Gene

Genomics for ARHGEF10 Gene

Regulatory Elements for ARHGEF10 Gene

Enhancers for ARHGEF10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGEF10 on UCSC Golden Path with GeneCards custom track

Promoters for ARHGEF10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGEF10 on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGEF10 Gene

1,823,976 bp from pter
1,958,641 bp from pter
134,666 bases
Plus strand

Genomic View for ARHGEF10 Gene

Genes around ARHGEF10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGEF10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGEF10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGEF10 Gene

Proteins for ARHGEF10 Gene

  • Protein details for ARHGEF10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Rho guanine nucleotide exchange factor 10
    Protein Accession:
    Secondary Accessions:
    • O14665
    • Q2KHR8
    • Q68D55
    • Q8IWD9
    • Q8IY77

    Protein attributes for ARHGEF10 Gene

    1369 amino acids
    Molecular mass:
    151612 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36809.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=AAH40474.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAA20754.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAH18365.1; Type=Erroneous termination; Positions=895; Note=Translated as Lys.; Evidence={ECO:0000305};

    Alternative splice isoforms for ARHGEF10 Gene


neXtProt entry for ARHGEF10 Gene

Proteomics data for ARHGEF10 Gene at MOPED

Post-translational modifications for ARHGEF10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGEF10 Gene

No data available for DME Specific Peptides for ARHGEF10 Gene

Domains & Families for ARHGEF10 Gene

Gene Families for ARHGEF10 Gene

Protein Domains for ARHGEF10 Gene

Suggested Antigen Peptide Sequences for ARHGEF10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 DH (DBL-homology) domain.
  • Contains 1 DH (DBL-homology) domain.
genes like me logo Genes that share domains with ARHGEF10: view

Function for ARHGEF10 Gene

Molecular function for ARHGEF10 Gene

UniProtKB/Swiss-Prot Function:
May play a role in developmental myelination of peripheral nerves.

Gene Ontology (GO) - Molecular Function for ARHGEF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005089 Rho guanyl-nucleotide exchange factor activity IDA 16896804
genes like me logo Genes that share ontologies with ARHGEF10: view

Phenotypes for ARHGEF10 Gene

genes like me logo Genes that share phenotypes with ARHGEF10: view

Human Phenotype Ontology for ARHGEF10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

miRNA for ARHGEF10 Gene

miRTarBase miRNAs that target ARHGEF10

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for ARHGEF10 Gene

Localization for ARHGEF10 Gene

Subcellular locations from

Jensen Localization Image for ARHGEF10 Gene COMPARTMENTS Subcellular localization image for ARHGEF10 gene
Compartment Confidence
cytosol 5
cytoskeleton 4
nucleus 3
extracellular 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for ARHGEF10 Gene

Pathways & Interactions for ARHGEF10 Gene

genes like me logo Genes that share pathways with ARHGEF10: view

Pathways by source for ARHGEF10 Gene

Gene Ontology (GO) - Biological Process for ARHGEF10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0022011 myelination in peripheral nervous system IEA,IMP 14508709
GO:0035023 regulation of Rho protein signal transduction IEA --
GO:0051496 positive regulation of stress fiber assembly IMP 16896804
GO:0090307 mitotic spindle assembly IEA,IMP 19635168
genes like me logo Genes that share ontologies with ARHGEF10: view

No data available for SIGNOR curated interactions for ARHGEF10 Gene

Drugs & Compounds for ARHGEF10 Gene

No Compound Related Data Available

Transcripts for ARHGEF10 Gene

Unigene Clusters for ARHGEF10 Gene

Rho guanine nucleotide exchange factor (GEF) 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF10 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c · 13d ^ 14 ^ 15 ^ 16 ^ 17 ^
SP5: - -
SP6: -
SP11: -
SP12: - - -
SP13: - - -
SP14: - -
SP15: - - -
SP16: -

ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b ^ 26 ^ 27a · 27b ^ 28 ^ 29

Relevant External Links for ARHGEF10 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for ARHGEF10 Gene

mRNA expression in normal human tissues for ARHGEF10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGEF10 Gene

This gene is overexpressed in Nerve - Tibial (x4.6).

Protein differential expression in normal tissues from HIPED for ARHGEF10 Gene

This gene is overexpressed in Lung (10.2), Gallbladder (9.6), Placenta (9.1), Testis (8.6), Fetal heart (6.7), and Spinal cord (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for ARHGEF10 Gene

SOURCE GeneReport for Unigene cluster for ARHGEF10 Gene Hs.98594

genes like me logo Genes that share expression patterns with ARHGEF10: view

Protein tissue co-expression partners for ARHGEF10 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGEF10 Gene

Orthologs for ARHGEF10 Gene

This gene was present in the common ancestor of animals.

Orthologs for ARHGEF10 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia ARHGEF10 35
  • 78.08 (n)
  • 79.95 (a)
  • 79 (a)
(Canis familiaris)
Mammalia ARHGEF10 35
  • 80.11 (n)
  • 83.32 (a)
  • 83 (a)
(Mus musculus)
Mammalia Arhgef10 35
  • 79.14 (n)
  • 80.88 (a)
Arhgef10 16
Arhgef10 36
  • 80 (a)
(Rattus norvegicus)
Mammalia Arhgef10 35
  • 78.65 (n)
  • 80 (a)
(Monodelphis domestica)
Mammalia ARHGEF10 36
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia ARHGEF10 36
  • 79 (a)
(Pan troglodytes)
Mammalia ARHGEF10 36
  • 97 (a)
(Gallus gallus)
Aves ARHGEF10 35
  • 72.5 (n)
  • 76.66 (a)
  • 76 (a)
(Anolis carolinensis)
Reptilia ARHGEF10 36
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgef10 35
  • 68.48 (n)
  • 69.8 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.8377 35
(Danio rerio)
Actinopterygii arhgef10 35
  • 66.03 (n)
  • 65.93 (a)
arhgef10 36
  • 57 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG8557 37
  • 28 (a)
CG43658 36
  • 18 (a)
Species with no ortholog for ARHGEF10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for ARHGEF10 Gene

Gene Tree for ARHGEF10 (if available)
Gene Tree for ARHGEF10 (if available)

Paralogs for ARHGEF10 Gene

Paralogs for ARHGEF10 Gene

(2) SIMAP similar genes for ARHGEF10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with ARHGEF10: view

Variants for ARHGEF10 Gene

Sequence variations from dbSNP and Humsavar for ARHGEF10 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
VAR_019118 Slowed nerve conduction velocity (SNCV)
rs2294039 -, - 1,909,425(+) TTGCC(A/G)TTCAC reference, missense
VAR_073288 -
rs2069167 -- 1,911,281(+) CATAC(C/T)TGCAT intron-variant
rs2069168 -- 1,911,305(+) ATCAC(A/G)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for ARHGEF10 Gene

Variant ID Type Subtype PubMed ID
nsv889697 CNV Gain 21882294
dgv7588n71 CNV Gain 21882294
dgv7590n71 CNV Gain 21882294
nsv889712 CNV Gain 21882294
dgv850n27 CNV Loss 19166990
nsv509244 CNV Insertion 20534489
nsv824454 CNV Gain 20364138
nsv470167 CNV Gain 18288195
nsv465277 CNV Gain 19166990
dgv7592n71 CNV Gain 21882294
dgv7593n71 CNV Loss 21882294
dgv7594n71 CNV Loss 21882294
nsv889724 CNV Gain 21882294
dgv7595n71 CNV Loss 21882294
nsv824455 CNV Gain 20364138
nsv889726 CNV Loss 21882294
esv2736322 CNV Deletion 23290073
esv2736323 CNV Deletion 23290073
esv4225 CNV Deletion 18987735
nsv395839 CNV Loss 16902084
esv2736324 CNV Deletion 23290073
esv1733120 CNV Deletion 17803354
esv23451 CNV Gain 19812545
esv2736325 CNV Deletion 23290073
esv2659595 CNV Deletion 23128226
esv2736326 CNV Deletion 23290073
esv2736327 CNV Deletion 23290073
esv2736328 CNV Deletion 23290073
esv1208772 CNV Insertion 17803354
esv1510196 CNV Insertion 17803354
esv27054 CNV Gain 19812545
esv2736330 CNV Deletion 23290073
esv2677306 CNV Deletion 23128226
esv2736331 CNV Deletion 23290073
esv2736332 CNV Deletion 23290073
esv2667351 CNV Deletion 23128226
esv2742063 CNV Deletion 23290073
esv1076332 CNV Insertion 17803354
esv2736333 CNV Deletion 23290073
esv1171195 CNV Insertion 17803354
nsv889729 CNV Gain 21882294
nsv831207 CNV Loss 17160897
nsv396415 CNV Insertion 16902084
esv2736334 CNV Deletion 23290073
esv2736335 CNV Deletion 23290073
esv2743130 CNV Deletion 23290073
nsv397138 CNV Loss 16902084
nsv6046 CNV Loss 18451855
nsv889730 CNV Loss 21882294
esv2736336 CNV Deletion 23290073
esv8802 CNV Gain 19470904
esv2736337 CNV Deletion 23290073
nsv398112 CNV Loss 16902084
esv1107716 CNV Deletion 17803354
nsv511395 CNV Loss 21212237
dgv1158n67 CNV Loss 20364138
esv28396 CNV Loss 19812545
dgv1234e201 CNV Deletion 23290073
dgv1260e199 CNV Deletion 23128226
dgv1159n67 CNV Loss 20364138
esv2084774 CNV Deletion 18987734
nsv824463 CNV Loss 20364138
esv2663389 CNV Deletion 23128226
esv2736339 CNV Deletion 23290073
nsv397324 CNV Loss 16902084
esv991834 CNV Deletion 20482838
esv2673010 CNV Deletion 23128226
esv2736341 CNV Deletion 23290073
esv2736342 CNV Deletion 23290073
esv993105 CNV Loss 20482838
esv1138141 CNV Deletion 17803354
esv2736344 CNV Deletion 23290073
esv2666010 CNV Deletion 23128226
esv3185 CNV Deletion 18987735
esv2736345 CNV Deletion 23290073
dgv1235e201 CNV Deletion 23290073
esv2736347 CNV Deletion 23290073
esv1620401 CNV Deletion 17803354
esv2736349 CNV Deletion 23290073
dgv1160n67 CNV Loss 20364138
esv1141021 CNV Insertion 17803354
esv1322301 CNV Insertion 17803354
esv1682354 CNV Insertion 17803354
esv2736352 CNV Deletion 23290073
esv2736353 CNV Deletion 23290073
esv2252959 CNV Deletion 18987734
esv2516234 CNV Deletion 19546169
nsv824472 CNV Loss 20364138
esv2415204 CNV Deletion 18987734
nsv397172 CNV Loss 16902084
esv1007633 CNV Deletion 20482838
esv2736354 CNV Deletion 23290073
esv2736355 CNV Deletion 23290073
esv26851 CNV Loss 19812545
esv2660560 CNV Deletion 23128226
dgv7596n71 CNV Loss 21882294
dgv7597n71 CNV Loss 21882294
nsv889735 CNV Loss 21882294
dgv7598n71 CNV Loss 21882294
esv2736356 CNV Deletion 23290073
nsv889739 CNV Loss 21882294
esv2736357 CNV Deletion 23290073
esv3957 CNV Deletion 18987735
esv2052269 CNV Deletion 18987734
esv1011319 CNV Deletion 20482838
esv2736358 CNV Deletion 23290073
esv1651457 CNV Deletion 17803354
esv2736359 CNV Deletion 23290073
esv1484821 CNV Insertion 17803354
esv2736360 CNV Deletion 23290073
esv1449111 CNV Deletion 17803354
esv2736361 CNV Deletion 23290073
nsv398111 CNV Insertion 16902084
nsv517213 CNV Loss 19592680

Variation tolerance for ARHGEF10 Gene

Residual Variation Intolerance Score: 75.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.29; 70.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGEF10 Gene

Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGEF10 Gene

Disorders for ARHGEF10 Gene

MalaCards: The human disease database

(1) MalaCards diseases for ARHGEF10 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, and Swiss-Prot

Disorder Aliases PubMed IDs
slowed nerve conduction velocity, ad
  • slowed nerve conduction velocity, autosomal dominant
- elite association - COSMIC cancer census association via MalaCards


  • Slowed nerve conduction velocity (SNCV) [MIM:608236]: Affected individuals present a reduction in nerve conduction velocities without any clinical signs of peripheral or central nervous system dysfunction. SNCV inheritance is autosomal dominant. {ECO:0000269 PubMed:14508709}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for ARHGEF10

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with ARHGEF10: view

No data available for Genatlas for ARHGEF10 Gene

Publications for ARHGEF10 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture. (PMID: 16896804) Mohl M. … Lutz S. (Naunyn Schmiedebergs Arch. Pharmacol. 2006) 2 3
  3. Genome-wide association study of selenium concentrations. (PMID: 25343990) Cornelis M.C. … He K. (Hum. Mol. Genet. 2015) 3
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. A genome-wide association study of brain lesion distribution in multiple sclerosis. (PMID: 23412934) Gourraud P.A. … Baranzini S.E. (Brain 2013) 3

Products for ARHGEF10 Gene

Sources for ARHGEF10 Gene