ARHGEF1 Gene
protein-coding GIFtS: 63
GCID: GC19P042387
|
|
Rho guanine nucleotide exchange factor (GEF) 1
| |
Aliases
for ARHGEF1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho Guanine Nucleotide Exchange Factor (GEF) 11 2 | | GEF12 | | LBCL21 2 5 | | LSC2 | | P115-RHOGEF1 2 | | Lsc Homolog2 | | SUB1.51 2 | | Rho Guanine Nucleotide Exchange Factor 12 | | 115 KDa Guanine Nucleotide Exchange Factor2 3 | | Sub1.53 | | P115RhoGEF1 | | P115-RhoGEF1 | | 115-KD Protein2 | | |
Export aliases for ARHGEF1 gene to outside databasesPrevious GC identifers: GC19P043026 GC19P042778 GC19P047063 GC19P047079 GC19P038818 |
Summaries
for ARHGEF1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARHGEF1:
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli thatwork through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulateRho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but thefull-length nature of some variants has not been defined. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: ARHG1_HUMAN, Q92888Function: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) andalpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotideexchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interactionwith the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-inducedRhoA activation
Gene Wiki entry for ARHGEF1
|
Genomic Views
for ARHGEF1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGEF1 gene promoter:
MyoD
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGEF1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGEF1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.13 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.13ARHGEF1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P042387: view genomic region
(about GC identifiers)
Start:
|
42,387,267 bp from pter |
End:
|
42,411,604 bp from pter |
Size:
|
24,338 bases |
Orientation:
|
plus strand |
|
Proteins
for ARHGEF1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ARHG1_HUMAN, Q92888 (See
protein sequence)Recommended Name: Rho guanine nucleotide exchange factor 1 Size: 912 amino acids; 102435 Da
Subunit: Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May interact with CCPG1(By similarity). Interacts with CTNNAL1
Subcellular location: Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or LPA stimulation
Sequence caution: Sequence=CAA70356.1; Type=Frameshift; Positions=904; Sequence=CAA70356.1; Type=Miscellaneousdiscrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part;
6/7 PDB 3D structures from  and Proteopedia  for ARHGEF1 (see all 7):1IAP (3D)
1SHZ (3D)
3AB3 (3D)
3ODO (3D)
3ODW (3D)
3ODX (3D)
Secondary accessions: O00513 Q8N4J4 Q96BF4 Q96F17 Q9BSB1Alternative splicing: 3 isoforms: Q92888-1 Q92888-2 Q92888-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for ARHGEF1: NX_Q92888
Post-translational modifications:
Phosphorylated by PKCA. Angiotensin-2 induced Tyr-738 phosphorylation is mediated by JAK21
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q92888
ARHGEF1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_004697.2 NP_945328.1 NP_945353.1
ENSEMBL proteins: ENSP00000367394 ENSP00000337261 ENSP00000346532 ENSP00000344429 Reactome Protein details: Q92888
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ARHGEF1 for ontologies About GeneDecksing
ARHGEF1 Antibody Products:
Assay Products for ARHGEF1: |
Protein
Domains /
Families
for ARHGEF1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGEF1 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q92888ProtoNet protein and cluster: Q92888 2 Blocks protein families: IPB000219 DH domain IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: ARHG1_HUMAN, Q92888Domain: The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activityDomain: The DH domain is involved in interaction with CCPG1 (By similarity)Similarity: Contains 1 DH (DBL-homology) domainSimilarity: Contains 1 PH domainSimilarity: Contains 1 RGSL (RGS-like) domain |
Function
for ARHGEF1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: ARHG1_HUMAN, Q92888Function: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) andalpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotideexchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interactionwith the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-inducedRhoA activation
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF1 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF1 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
ARHGEF1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ARHGEF1:
Animal Models:
Mouse knock-outs for ARHGEF1: Arhgef1tm1Djle Arhgef1tm1Kdf Arhgef1tm1.1Rmt
6 MGI mutant phenotypes (inferred from 4 alleles ) (MGI details for Arhgef1):
ARHGEF1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for ARHGEF1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/30 super-pathways (see all 30) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling_Regulation of p38 and JNK signaling mediated by G-proteins | | | 2 | GPCR Pathway | | | 3 | G-AlphaQ Signaling | | | 4 | Signaling by GPCR | | | 5 | G-protein signaling_RhoA regulation pathway | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 EMD Millipore Pathways for ARHGEF1
5/24 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGEF1 (see all 24)
1 
Cell Signaling Technology (CST) Pathway for ARHGEF1
3  GeneGo (Thomson Reuters) Pathways for ARHGEF1
5/6  BioSystems Pathways for ARHGEF1 (see all 6)
5/8 
Reactome Pathways for ARHGEF1 (see all 8)
2 
Kegg Pathways (Kegg details for ARHGEF1):
ARHGEF1 for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGEF1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/793 Interacting proteins for ARHGEF1 (Q928881, 2, 3 ENSP000003372614) via UniProtKB, MINT, STRING, and/or I2D (see all 793)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| CSNK1E | P496742, 3, ENSP000003529294 | MINT-8252681 I2D:
score=2 STRING: ENSP00000352929 | | GNA12 | Q031132, 3, ENSP000002753644 | MINT-7909421 I2D:
score=1 STRING: ENSP00000275364 | | GNA13 | Q143441, 2, 3, ENSP000004007174 | EBI-465400,EBI-465387 MINT-7909440 I2D:
score=4 STRING: ENSP00000400717 | | ATR | Q135352, 3, ENSP000003437414 | MINT-7945693 I2D:
score=1 STRING: ENSP00000343741 | | CDC5L | Q994592, ENSP000003605324 | MINT-7945693 MINT-7947479 STRING: ENSP00000360532 |
About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007266 | Rho protein signal transduction |
TAS | 10747909 | | GO:0008283 | cell proliferation |
TAS | 8810315 | | GO:0035023 | regulation of Rho protein signal transduction |
IEA | -- | | GO:0038032 | termination of G-protein coupled receptor signaling pathway |
IEA | -- | | GO:0048011 | nerve growth factor receptor signaling pathway |
TAS | -- |
ARHGEF1 for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGEF1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ARHGEF1 for compounds About GeneDecksing
 Browse Tocris compounds for ARHGEF1
3 HMDB Compounds for ARHGEF1 About this table
3 Novoseek chemical compound relationships for ARHGEF1 gene About this table
Search CenterWatch for drugs/clinical trials and news about ARHGEF1 / ARHG1
|
Transcripts
for ARHGEF1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGEF1 gene (3 alternative transcripts): NM_004706.3 NM_198977.1 NM_199002.1 Unigene Cluster for ARHGEF1: Rho guanine nucleotide exchange factor (GEF) 1 Hs.631550 [show with all ESTs]Unigene Representative Sequence: BC0649964 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000378152(uc002osc.3) ENST00000337665(uc002osa.3 uc002osb.3)
ENST00000354532(uc002orw.1 uc002orx.3 uc002orz.3) ENST00000347545(uc002ory.3 uc002osd.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF1 (see all 9)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF1 (see all 4)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ARHGEF1 (NM_004706) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGEF1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGEF1 |
Additional cDNA sequence: AL832294.1 BC005155.2 BC011726.2 BC015652.2 BC034013.1 BC035127.1 BC064996.1 BC067262.1 BT007421.1 U64105.1 XR_109536.2 XR_133186.2 XR_172294.1 22 DOTS entries: DT.100801442 DT.100039607 DT.97779113 DT.92438951 DT.95211158 DT.121643665 DT.97760161 DT.100801445 DT.100800053 DT.92438958 DT.95260447 DT.95322545 DT.97760163 DT.121443288 DT.441034 DT.91668555 DT.92438950 DT.95155326 DT.102833291 DT.75110803 DT.95221875 DT.113454 24/343 AceView cDNA sequences (see all 343): BF849717 BQ711445 BG767937 NM_004706 CA432485 BM453312 CR620754 BQ231304 BQ054055 AI865820 BF309508 BQ216833 AA767251 BM449539 BX405132 BC064996 BQ944132 BF797227 BE829613 BQ220172 BC067262 BQ052766 BC011726 BU619410
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF1 (see all 12) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | |
| SP2: | | | | | | | | | - | | - | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | | | - | | | | | | - | | | | | | | | | | | | | | | | - | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | |
| ExUns: | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22 | ^ | 23 | ^ | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 | ^ | 30 | ^ | 31 | ^ | 32 |
|---|
|
| SP1: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP5: | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | |
ECgene alternative splicing isoforms for ARHGEF1
|
Expression
for ARHGEF1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGEF1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See ARHGEF1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGEF1
SOURCE GeneReport for Unigene cluster: Hs.631550
UniProtKB/Swiss-Prot: ARHG1_HUMAN, Q92888Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for ARHGEF1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGEF1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGEF1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGEF1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF1 |
Orthologs
for ARHGEF1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for ARHGEF1 gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
arhgef1b6 |
Rho guanine nucleotide exchange factor (GEF) 1b |
33(a) |
1 ↔ 1 |
16(28391679-28483195) |
fruit fly
(Drosophila melanogaster) |
Insecta |
RhoGEF23 |
gastrulation diacylglycerol binding |
36(a) |
|
-- |
worm
(Caenorhabditis elegans) |
Secernentea |
F13E6.63 |
Tiam-1 like protein |
35(a) |
|
X(10733408-10738294) -- |
ENSEMBL Gene Tree for ARHGEF1 (if available)
TreeFam Gene Tree for ARHGEF1 (if available) |
Paralogs
for ARHGEF1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGEF1 gene
- ARHGEF22 ARHGEF32 ARHGEF112 NET12 ARHGEF122 ARHGEF182 AKAP132 ARHGEF282
8 SIMAP similar genes for ARHGEF1 using alignment to 11 protein entries: ARHG1_HUMAN (see all proteins):FLJ00369 ARHGEF11 ARHGEF12 AKAP13 ARHGEF2 ARHGEF28
ARHGEF18 NET1
ARHGEF1 for paralogs About GeneDecksing
|
Genomic Variants
for ARHGEF1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGEF1 (42387267 - 42411604 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for ARHGEF1
1 CNV: 73373
1 Indel: 45774 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGEF1 |
|
Disorders
/ Diseases
for ARHGEF1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGEF1 for disorders About GeneDecksing
OMIM gene information: 601855
OMIM disorders: --
18  diseases for ARHGEF1: About MalaCardsoculomotor nerve paralysis facial hemiatrophy localized scleroderma aagenaes syndrome
skin lipoma gitelman syndrome poliomyelitis scleroderma
breast cancer spasticity pancreatic cancer prostate cancer
pancreatitis hypertension prostatitis leukemia
neuronitis adenocarcinoma
5 diseases from the University of Copenhagen DISEASES database for ARHGEF1:Poliomyelitis Localized scleroderma Leukemia Aagenaes syndrome
Skin lipoma 1 Novoseek disease relationship for ARHGEF1 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| breast cancer |
0 |
1 |
12748184 (1) |
Human Genome Epidemiology (HuGE) Navigator: ARHGEF1 (4 documents)
Export disorders for ARHGEF1 gene to outside databases
|
Publications
for ARHGEF1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGEF1 gene, integrated from 9 sources (see all 86):
(articles sorted by number of sources associating them with ARHGEF1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues. (PubMed id 9135076)1, 2, 3, 9 Aasheim H.-C.... Smeland E.B. (1997)
- Identification of a novel guanine nucleotide exchange factor for the rho GTPase. (PubMed id 8810315)1, 2, 3 Hart M.J....Bollag G. (1996)
- PKCa-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. (PubMed id 12754211)1, 2, 9 Holinstat M.... Malik A.B. (2003)
- Structure of the rgRGS domain of p115RhoGEF. (PubMed id 11524686)1, 2, 9 Chen Z.... Sprang S.R. (2001)
- Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. (PubMed id 9641916)1, 2, 9 Hart M.J.... Bollag G. (1998)
- p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. (PubMed id 9641915)1, 2, 9 Kozasa T.... Sternweis P.C. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Association of Lbc Rho guanine nucleotide exchange factor with alpha- catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. (PubMed id 12270917)1, 2 Park B.... Toksoz D. (2002)
- Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. (PubMed id 10747909)1, 2 Bhattacharyya R. and Wedegaertner P.B. (2000)
- Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF. (PubMed id 12534370)1, 9 Bhattacharyya R. and Wedegaertner P.B. (2003)
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External Searches for ARHGEF1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ARHGEF1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing ARHGEF1 gene
(According to HUGE)
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Specialized Databases showing ARHGEF1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Patent Information for ARHGEF1 gene:
Search GeneIP for patents involving ARHGEF1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ARHGEF1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for ARHGEF1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGEF1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGEF1 | | | OriGene Protein Over-expression Lysate for ARHGEF1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARHGEF1 | | OriGene 3'-UTR Clone for ARHGEF1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGEF1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ARHGEF1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGEF1 |
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