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ARHGEF1 Gene

protein-coding GIFtS: 60

GC19P047079

Rho guanine nucleotide exchange factor (GEF) 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
GEF1 ^²
LBCL2 ^¹, ², ⁵
LSC ^²
P115-RHOGEF ^¹, ²
SUB1.5 ^¹, ²
Sub1.5 ^³
p115-RhoGEF ^³
p115RhoGEF ^³

Descriptions
115 kDa guanine nucleotide exchange factor ^³
115-kD protein ^²
Lsc homolog ^²
Rho guanine nucleotide exchange factor (GEF) 1 ^²
Rho guanine nucleotide exchange factor 1 ^²

External Ids
HGNC: 681¹
Entrez Gene: 9138²
UniProtKB: Q92888³
Ensembl: ENSG00000076928⁷

Search outside databases for aliases for ARHGEF1 gene

Previous GC identifers: GC19P043026 GC19P042778 GC19P047063

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for ARHGEF1:

Rho GTPases play a fundamental role in numerous cellular processes that are initiated by

extracellular stimuli that work through G protein coupled receptors. The encoded protein may form

complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced

transcript variants have been found for this gene, but the full-length nature of some variants has

not been defined. [provided by RefSeq]

UniProtKB/Swiss-Prot: ARHG1_HUMAN, Q92888

Function: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding

alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12

and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha

13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF

activity is inhibited by binding to activated GNA12

Gene Wiki entry for ARHGEF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the ARHGEF1 gene

Entrez Gene cytogenetic band: 19q13.13 Ensembl cytogenetic band: 19q13.2 HGNC cytogenetic band: 19q13.13

ARHGEF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P047079: (about GC identifiers)

Start:	47,079,106 bp from pter
End:	47,103,444 bp from pter
Size:	24,339 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000019.8 NT_011109.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: ARHG1_HUMAN, Q92888 (See protein sequence)

Recommended Name: Rho guanine nucleotide exchange factor 1

Size: 912 amino acids; 102435 Da

Subunit: Interacts with RHOA, GNA12 and GNA13. Homooligomerizes through the coiled coil region. May

interact with CCPG1 (By similarity). Interacts with CTNNAL1

Subcellular location: Cytoplasm. Membrane. Note=Translocated to the membrane by activated GNA13 or

LPA stimulation

Sequence caution: Sequence=CAA70356.1; Type=Frameshift; Positions=904; Sequence=CAA70356.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the

N-terminal part;

PDB structure from and Proteopedia :

1IAP (3D)

1SHZ (3D)

Secondary accessions: O00513 Q8N4J4 Q96BF4 Q96F17 Q9BSB1

Alternative splicing: 2 isoforms: Q92888-1 Q92888-2

Post-translational modifications:

Phosphorylated by PKCA¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_004697.2 NP_945328.1 NP_945353.1

ENSEMBL proteins:

ENSP00000323044 ENSP00000337261 ENSP00000367394 ENSP00000344429 ENSP00000346532 ENSP00000375841

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (ARHGEF1)
	Human Recombinant Proteins from Abnova (ARHGEF1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

4 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	TAS	10747909
GO:0005829	cytosol	EXP	11313914
GO:0005886	plasma membrane	TAS	10747909

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Antibodies for ARHGEF1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for ARHGEF1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for ARHGEF1 (p115 RhoGEF)
	Antibodies from Abcam (ARHGEF1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (ARHGEF1)
	Novus Biologicals Antibodies for ARHGEF1

Assays for ARHGEF1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q92888

ProtoNet protein and cluster: Q92888

2 Blocks protein families:

IPB000219 DH domain

IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: ARHG1_HUMAN, Q92888

Domain: The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP

activity

Domain: The DH domain is involved in interaction with CCPG1 (By similarity)

Similarity: Contains 1 DH (DBL-homology) domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 RGSL (RGS-like) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARHGEF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ARHGEF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004706

Applied Biosystems Silencer® siRNAs for ARHGEF1

Sigma-Aldrich siRNA and siRNA Panels for ARHGEF1

Sigma-Aldrich shRNA for ARHGEF1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for ARHGEF1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_004706
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_004706
untagged cDNA clones in CMV expression vector (see all 4): NM_004706

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_199002

UniProtKB/Swiss-Prot: ARHG1_HUMAN, Q92888

Function: Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding

alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12

and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha

13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF

activity is inhibited by binding to activated GNA12

2 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Arhgef1):

hematopoietic system

immune system

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005085	guanyl-nucleotide exchange factor activity	IEA	--
GO:0005089	Rho guanyl-nucleotide exchange factor activity	TAS	8810315
GO:0005096	GTPase activator activity	IEA	--
GO:0005515	protein binding	IPI	12681510

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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4 Sigma-Aldrich "Your Favorite Gene" Pathways for ARHGEF1 (Your Favorite Gene powered by Ingenuity)

Molecular Mechanisms of Cancer
Actin Cytoskeleton Signaling
Reelin Signaling in Neurons
Thrombin Signaling

GeneDecks ARHGEF1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for ARHGEF1

5/28 Interacting proteins for ARHGEF1 (ENSP00000367394³ Q92888¹) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GNA13	Q14344¹	STRING (score=.995) EBI-465400, EBI-465387
ARHGDIA	ENSP00000269321³	STRING (score=.962)
GNAQ	ENSP00000286548³	STRING (score=.961)
GNA12	ENSP00000275364³	STRING (score=.96)
ARHGAP5	ENSP00000371897³	STRING (score=.951)

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008283	cell proliferation	TAS	8810315
GO:0035023	regulation of Rho protein signal transduction	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for ARHGEF1
2 Novoseek chemical compound relationships for ARHGEF1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gtp	46.61	1	12024019 (1)
tyrosine	1.27	1	10821841 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (ARHGEF1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (ARHGEF1)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_004706

Sigma-Aldrich siRNA and siRNA Panels for ARHGEF1

Sigma-Aldrich shRNA for ARHGEF1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004706 NM_198977 NM_199002

REFSEQ mRNAs for ARHGEF1 gene (3 alternative transcripts):

NM_004706.3 NM_198977.1 NM_199002.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004706 NM_198977 NM_199002

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_004706
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_004706
                                 untagged cDNA clones in CMV expression vector (see all 4): NM_004706

Additional cDNA sequence:

AL832294.1 BC005155.2 BC011726.2 BC015652.2 BC034013.1 BC035127.1 BC064996.1 BC067262.1

BT007421.1 CR615730.1 CR620754.1 U64105.1

20 DOTS entries:

DT.100801442 DT.100039607 DT.97779113 DT.92438951 DT.95211158 DT.121643665 DT.97760161 DT.100801445

DT.95260447 DT.100800053 DT.92438958 DT.95322545 DT.97760163 DT.121443288 DT.92438950 DT.95155326

DT.102833291 DT.75110803 DT.95221875 DT.113454

24/343 AceView cDNA sequences (see all 343 ):

CA432485 BQ708891 BG983189 CD672465 BQ962579 BQ652652 BQ073261 AW651746

BF849717 BC015652 BE797545 AA767251 BG767937 BU155745 BT007421 BQ052766

BU149429 BQ054055 BQ220172 AL832294 BC067262 BU155646 BQ231304 AI865820

highest scoring ESTs for ARHGEF1:

U64105 AA281559 AA297511 AA303003 AA481277 AA632772 AA767251 AA827436 AA872531 AI365400

Unigene Cluster for ARHGEF1:

Rho guanine nucleotide exchange factor (GEF) 1

Hs.631550 [show with all ESTs]

Unigene Representative Sequence: BC064996

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGEF1 (see all 12 )

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16a	·	16b	^
SP1:																									-						-																-		-
SP2:									-		-														-						-																-		-
SP3:									-		-								-		-				-						-																-		-
SP4:																			-		-				-						-																-		-
SP5:																																																	-

ExUns:	17	^	18	^	19	^	20	^	21a	·	21b	^	22	^	23	^	24	^	25	^	26	^	27	^	28	^	29	^	30	^	31	^	32
SP1:	-
SP2:	-
SP3:	-
SP4:	-																												-
SP5:	-																												-

About this scheme

ECgene alternative splicing isoforms for ARHGEF1

6 Ensembl transcripts including schematic representations:

ENST00000316079 ENST00000337665 ENST00000378152 ENST00000347545 ENST00000354532 ENST00000391981

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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ARHGEF1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for ARHGEF1

¹ / ² / ³

5 probe-sets matching ARHGEF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38445_at²^{, 3}	U95-A	1	1.00	1.00	0.98	1.03	Y09160	0.60	0.75	0.68	1
810_at²^{, 3}	U95-A	1	1.00	1.00	0.98	0.97	U64105	1.00	1.00	1.00	1
203055_s_at²^{, 3}	U133-A	2	1.00	0.95	--	--	NM_004706	0.60	1.00	0.82	1
1560445_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203055_s_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.631550
Expression variation in blood from EXPOLDB for ARHGEF1
UniProtKB/Swiss-Prot: ARHG1_HUMAN, Q92888
Tissue specificity: Ubiquitously expressed

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for ARHGEF1 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	ARHGEF1¹	--	Rho guanine nucleotide exchange factor (GEF) 1	86.76(n) 85.42(a)	513377 XM_591046.3 XP_591046.3
rat (Rattus norvegicus)	Arhgef1¹	--	Rho guanine nucleotide exchange factor (GEF) 1	85.65(n) 89.37(a)	60323 NM_021694.3 NP_067726.3
mouse (Mus musculus)	Arhgef1^{1, 5}	7⁵	Rho guanine nucleotide exchange factor (GEF) 1^{1, 5}	86.17(n)¹ 89.21(a)¹	16801¹ NM_008488.1¹ NP_032514.1¹ AK012156⁵ AK040093⁵ (see all 27)
fruit fly (Drosophila melanogaster)	RhoGEF2³	53E10--F1	gastrulation diacylglycerol binding	36(a)	--
worm (Caenorhabditis elegans)	F13E6.6³	X(10733408-10738294)	Tiam-1 like protein	35(a)	--

About this table Species with no ortholog for ARHGEF1

ENSEMBL Gene Tree for ARHGEF1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for ARHGEF1 gene

ARHGEF12² ARHGEF11²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/122 NCBI SNPs in ARHGEF1 are shown (see all 122 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 42)

AB	SNP ID	Valid	Chr 19 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs2303797^1,2	F,H	47094433(+)	`CAGCCC/TCGAGC`	3	P/L	mis¹		5	EA EU WA	1912
	rs891167^1,2	C,H	47079643(+)	`ACAACA/GATAAC`	3	--	ng5¹ int¹		5	MN EU EA WA	578
	rs11083640^1,2	C,F,H	47100266(+)	`GAGCGA/GCTGCT`	3	R/R	syn¹ ese³		5	NA EU EA	466
	rs2288509^1,2	C,F,H	47084150(+)	`ATCATC/TGGGGC`	3	I/I	syn¹		8	EA NA EU WA	2036
	rs6509003^1,2	A,C,F,H	47091781(+)	`CCATCC/GTTACA`	3	--	int¹		4	EU EA WA	418
	rs8113686^1,2	A,C,F,H	47088106(+)	`CCCCAG/ACCTCT`	3	--	int¹		7	NA EU EA WA	558
	rs8110305^1,2	A,C,F,H	47087534(+)	`gctccG/Attttc`	3	--	int¹		4	EU EA WA	420
	rs11880977^1,2	A,C,F,H	47082919(+)	`TGGGAG/AAGACA`	3	--	int¹		4	EU EA WA	418
	rs717225^1,2	A,C,F,H	47085126(-)	`AGAGTC/TCACGG`	3	--	int¹		19	NS EA NA EU WA	1342
	rs12104228^1,2	A,C,F,H	47090290(+)	`CTGGAT/CACCTA`	3	--	int¹		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for ARHGEF1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601855

1 Novoseek disease relationship for ARHGEF1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	0.00	1	12748184 (1)

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(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/55 PubMed articles for ARHGEF1 gene (see all 55 ):

Characterization, expression and chromosomal localization of a human gene homologous to the mouse Lsc oncogene, with strongest expression in hematopoetic tissues. (PubMed id 9135076)^{1, 2, 3, 4} Aasheim H.C....Smeland E.B. (1997)
Identification of a novel guanine nucleotide exchange factor for the rho GTPase. (PubMed id 8810315)^{2, 3, 4} Hart M.J....Bollag G. (1996)
PKCa-induced p115RhoGEF phosphorylation signals endothelial cytoskeletal rearrangement. (PubMed id 12754211)^{1, 3, 4} Holinstat M.... Malik A.B. (2003)
Structure of the rgRGS domain of p115RhoGEF. (PubMed id 11524686)^{1, 3, 4} Chen Z.... Sprang S.R. (2001)
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. (PubMed id 9641916)^{1, 3, 4} Hart M.J.... Bollag G. (1998)
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. (PubMed id 9641915)^{1, 3, 4} Kozasa T.... Sternweis P.C. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Association of Lbc Rho guanine nucleotide exchange factor with alpha- catenin-related protein, alpha-catulin/CTNNAL1, supports serum response factor activation. (PubMed id 12270917)^{3, 4} Park B.... Toksoz D. (2002)
Galpha 13 requires palmitoylation for plasma membrane localization, Rho-dependent signaling, and promotion of p115-RhoGEF membrane binding. (PubMed id 10747909)^{3, 4} Bhattacharyya R. and Wedegaertner P.B. (2000)
Characterization of G alpha 13-dependent plasma membrane recruitment of p115RhoGEF. (PubMed id 12534370)^{1, 3} Bhattacharyya R. and Wedegaertner P.B. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 9138	HGNC: 681	AceView: ARHGEF1	Ensembl:ENSG00000076928	euGenes: HUgn9138
ECgene: ARHGEF1	H-InvDB: ARHGEF1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for ARHGEF1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for ARHGEF1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for ARHGEF1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for ARHGEF1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for ARHGEF1		Antibodies for ARHGEF1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for ARHGEF1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
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	Recombinant & Natural Proteins

	Recombinant Proteins (ARHGEF1)
	Antibodies (ARHGEF1)
	Chimera RNAi (ARHGEF1)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for ARHGEF1 (p115 RhoGEF)

	Recombinant Proteins (ARHGEF1)
	Antibodies (ARHGEF1)

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Antibodies for ARHGEF1

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ARHGEF1 Gene at Home site.
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ARHGEF1 Gene

protein-coding GIFtS: 60

Aliases &
Descriptions
for ARHGEF1

Summaries
for ARHGEF1

Genomic Location
for ARHGEF1

Proteins
for ARHGEF1

Protein Domains/
Families
for ARHGEF1

Gene Function
for ARHGEF1

Pathways & Interactions
for ARHGEF1

Drugs & Compounds
for ARHGEF1

Transcripts
for ARHGEF1

Expression
for ARHGEF1

Orthologs
for ARHGEF1

Paralogs
for ARHGEF1

SNPs/Variants
for ARHGEF1

Disorders & Mutations
for ARHGEF1

Medical News
for ARHGEF1

Publications
for ARHGEF1

Search for ARHGEF1

Genome Databases showing ARHGEF1

Other Databases showing ARHGEF1

Specialized Databases showing ARHGEF1

Licensable Technologies
for ARHGEF1

Services
for ARHGEF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

ARHGEF1 Gene

protein-coding GIFtS: 60

Aliases & Descriptionsfor ARHGEF1

Summariesfor ARHGEF1

Genomic Locationfor ARHGEF1

Proteinsfor ARHGEF1

Protein Domains/Familiesfor ARHGEF1

Gene Functionfor ARHGEF1

Pathways & Interactionsfor ARHGEF1

Drugs & Compoundsfor ARHGEF1

Transcriptsfor ARHGEF1

Expression for ARHGEF1

Orthologsfor ARHGEF1

Paralogsfor ARHGEF1

SNPs/Variantsfor ARHGEF1

Disorders & Mutationsfor ARHGEF1

Medical Newsfor ARHGEF1

Publicationsfor ARHGEF1

Search for ARHGEF1

Genome Databases showing ARHGEF1

Other Databases showing ARHGEF1

Specialized Databases showing ARHGEF1

Licensable Technologiesfor ARHGEF1

Servicesfor ARHGEF1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for ARHGEF1

Summaries
for ARHGEF1

Genomic Location
for ARHGEF1

Proteins
for ARHGEF1

Protein Domains/
Families
for ARHGEF1

Gene Function
for ARHGEF1

Pathways & Interactions
for ARHGEF1

Drugs & Compounds
for ARHGEF1

Transcripts
for ARHGEF1

Expression
for ARHGEF1

Orthologs
for ARHGEF1

Paralogs
for ARHGEF1

SNPs/Variants
for ARHGEF1

Disorders & Mutations
for ARHGEF1

Medical News
for ARHGEF1

Publications
for ARHGEF1

Licensable Technologies
for ARHGEF1

Services
for ARHGEF1