Aliases for ARHGEF1 Gene
External Ids for ARHGEF1 Gene
Previous GeneCards Identifiers for ARHGEF1 Gene
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]
GeneCards Summary for ARHGEF1 Gene
ARHGEF1 (Rho Guanine Nucleotide Exchange Factor 1) is a Protein Coding gene. Diseases associated with ARHGEF1 include skin lipoma and paralytic poliomyelitis. Among its related pathways are Signaling by GPCR and p75 NTR receptor-mediated signalling. GO annotations related to this gene include poly(A) RNA binding and Rho guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF12.
UniProtKB/Swiss-Prot for ARHGEF1 Gene
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.