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Aliases for ARHGDIG Gene

Aliases for ARHGDIG Gene

  • Rho GDP Dissociation Inhibitor (GDI) Gamma 2 3
  • Rho-GDI Gamma 3 4
  • RhoGDI Gamma 2 3
  • Rho GDI 3 3 4
  • Rho GDP-Dissociation Inhibitor 3 3
  • RHOGDI-3 3

External Ids for ARHGDIG Gene

Previous GeneCards Identifiers for ARHGDIG Gene

  • GC16P000349
  • GC16P000270
  • GC16P000318
  • GC16P000250

Summaries for ARHGDIG Gene

Entrez Gene Summary for ARHGDIG Gene

  • The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]

GeneCards Summary for ARHGDIG Gene

ARHGDIG (Rho GDP Dissociation Inhibitor (GDI) Gamma) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIB.

UniProtKB/Swiss-Prot for ARHGDIG Gene

  • Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP

Gene Wiki entry for ARHGDIG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGDIG Gene

Genomics for ARHGDIG Gene

Regulatory Elements for ARHGDIG Gene

Genomic Location for ARHGDIG Gene

Start:
268,727 bp from pter
End:
283,010 bp from pter
Size:
14,284 bases
Orientation:
Plus strand

Genomic View for ARHGDIG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for ARHGDIG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGDIG Gene

Proteins for ARHGDIG Gene

  • Protein details for ARHGDIG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99819-GDIR3_HUMAN
    Recommended name:
    Rho GDP-dissociation inhibitor 3
    Protein Accession:
    Q99819
    Secondary Accessions:
    • Q4TT69
    • Q96S29

    Protein attributes for ARHGDIG Gene

    Size:
    225 amino acids
    Molecular mass:
    25098 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARHGDIG Gene

Proteomics data for ARHGDIG Gene at MOPED

Post-translational modifications for ARHGDIG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGDIG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for ARHGDIG Gene

Domains for ARHGDIG Gene

Protein Domains for ARHGDIG Gene

Graphical View of Domain Structure for InterPro Entry

Q99819

UniProtKB/Swiss-Prot:

GDIR3_HUMAN :
  • Q99819
Family:
  • Belongs to the Rho GDI family.
genes like me logo Genes that share domains with ARHGDIG: view

No data available for Gene Families for ARHGDIG Gene

Function for ARHGDIG Gene

Molecular function for ARHGDIG Gene

GENATLAS Biochemistry: Rho GDP-dissociation inhibitor (GDI) gamma,preferentially expressed in brain and pancreas,binding to RHOA and CDC42
UniProtKB/Swiss-Prot Function: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP

Gene Ontology (GO) - Molecular Function for ARHGDIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005092 GDP-dissociation inhibitor activity --
GO:0005094 Rho GDP-dissociation inhibitor activity IEA --
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with ARHGDIG: view

Phenotypes for ARHGDIG Gene

MGI mutant phenotypes for ARHGDIG:
inferred from 1 alleles
GenomeRNAi human phenotypes for ARHGDIG:
genes like me logo Genes that share phenotypes with ARHGDIG: view

Animal Models for ARHGDIG Gene

MGI Knock Outs for ARHGDIG:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGDIG

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for ARHGDIG Gene

Localization for ARHGDIG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGDIG Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGDIG Gene COMPARTMENTS Subcellular localization image for ARHGDIG gene
Compartment Confidence
cytosol 4
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARHGDIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0016020 membrane IEA --
GO:0016023 cytoplasmic membrane-bounded vesicle TAS 9113980
genes like me logo Genes that share ontologies with ARHGDIG: view

Pathways for ARHGDIG Gene

genes like me logo Genes that share pathways with ARHGDIG: view

Gene Ontology (GO) - Biological Process for ARHGDIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007162 negative regulation of cell adhesion TAS 9113980
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007266 Rho protein signal transduction TAS 9113980
GO:0032880 regulation of protein localization IEA --
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGDIG: view

Compounds for ARHGDIG Gene

(2) HMDB Compounds for ARHGDIG Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with ARHGDIG: view

Transcripts for ARHGDIG Gene

mRNA/cDNA for ARHGDIG Gene

Unigene Clusters for ARHGDIG Gene

Rho GDP dissociation inhibitor (GDI) gamma:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for ARHGDIG

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for ARHGDIG
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIG Gene

No ASD Table

Relevant External Links for ARHGDIG Gene

GeneLoc Exon Structure for
ARHGDIG
ECgene alternative splicing isoforms for
ARHGDIG

Expression for ARHGDIG Gene

mRNA expression in normal human tissues for ARHGDIG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGDIG Gene

This gene is overexpressed in Brain - Cortex (6.1), Brain - Cerebellum (5.8), Brain - Anterior cingulate cortex (BA24) (5.4), Brain - Frontal Cortex (BA9) (5.1), and Brain - Cerebellar Hemisphere (4.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for ARHGDIG Gene

SOURCE GeneReport for Unigene cluster for ARHGDIG Gene Hs.647388

mRNA Expression by UniProt/SwissProt for ARHGDIG Gene

Q99819-GDIR3_HUMAN
Tissue specificity: Primarily expressed in pancreas and brain
genes like me logo Genes that share expressions with ARHGDIG: view

In Situ Assay Products

Orthologs for ARHGDIG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGDIG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGDIG 35
  • 98.84 (n)
  • 99 (a)
ARHGDIG 36
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGDIG 35
  • 86.76 (n)
  • 85.27 (a)
ARHGDIG 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGDIG 35
  • 83.66 (n)
  • 80.88 (a)
ARHGDIG 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgdig 35
  • 81.93 (n)
  • 79.56 (a)
Arhgdig 16
Arhgdig 36
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia ARHGDIG 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGDIG 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgdig 35
  • 82.67 (n)
  • 81.78 (a)
chicken
(Gallus gallus)
Aves ARHGDIG 35
  • 74.96 (n)
  • 66.22 (a)
ARHGDIG 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgdig 35
  • 61.98 (n)
  • 59.3 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgdig 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGDI 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rhi-1 36
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDI1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for ARHGDIG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGDIG Gene

ENSEMBL:
Gene Tree for ARHGDIG (if available)
TreeFam:
Gene Tree for ARHGDIG (if available)

Paralogs for ARHGDIG Gene

Paralogs for ARHGDIG Gene

Selected SIMAP similar genes for ARHGDIG Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ARHGDIG: view

Variants for ARHGDIG Gene

Sequence variations from dbSNP and Humsavar for ARHGDIG Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs369440 -- 280,925(+) GGGGA(A/G)GGGAC intron-variant
rs373271 -- 279,671(+) AGCTC(C/T)TTGGC upstream-variant-2KB
rs421123 -- 279,578(-) CACAA(C/T)CTTTC upstream-variant-2KB
rs448971 -- 279,211(-) CAAAG(A/G)AACCT upstream-variant-2KB
rs2238371 -- 278,916(+) ATGCC(C/G)CACAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARHGDIG Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2458n71 CNV Loss 21882294
nsv904652 CNV Loss 21882294
dgv32n68 CNV Loss 17160897
dgv2465n71 CNV Loss 21882294
dgv2466n71 CNV Loss 21882294
nsv904674 CNV Loss 21882294
nsv827477 CNV Gain 20364138
dgv2467n71 CNV Loss 21882294
nsv904677 CNV Loss 21882294
dgv2468n71 CNV Loss 21882294
dgv2469n71 CNV Loss 21882294
dgv2470n71 CNV Loss 21882294
nsv904690 CNV Loss 21882294

Relevant External Links for ARHGDIG Gene

HapMap Linkage Disequilibrium report
ARHGDIG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGDIG Gene

Disorders for ARHGDIG Gene

Relevant External Links for ARHGDIG

Genetic Association Database (GAD)
ARHGDIG
Human Genome Epidemiology (HuGE) Navigator
ARHGDIG
genes like me logo Genes that share disorders with ARHGDIG: view

No data available for UniProtKB/Swiss-Prot for ARHGDIG Gene

Publications for ARHGDIG Gene

  1. RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. (PMID: 9113980) Adra C.N. … Lim B. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4
  2. Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3. (PMID: 9787082) Adra C.N. … Higgs D.R. (Genomics 1998) 3 4
  3. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  4. RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain. (PMID: 11967128) Brunet N. … Olofsson B. (Traffic 2002) 2 3
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4

Products for ARHGDIG Gene

Sources for ARHGDIG Gene

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