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ARHGDIG Gene

protein-coding   GIFtS: 55
GCID: GC16P000318

Rho GDP Dissociation Inhibitor (GDI) Gamma

  Search for ARHGDIG
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GDP Dissociation Inhibitor (GDI) Gamma1 2
RhoGDI Gamma1 2
Rho GDI 32 3
Rho-GDI Gamma2 3
RHOGDI-32
Rho GDP-Dissociation Inhibitor 32

External Ids:    HGNC: 6801   Entrez Gene: 3982   Ensembl: ENSG000002421737   OMIM: 6028445   UniProtKB: Q998193   

Export aliases for ARHGDIG gene to outside databases

Previous GC identifers: GC16P000349 GC16P000270 GC16P000250


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGDIG Gene:
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting
the exchange of GDP for GTP. See ARHGDIB (MIM 602843).(supplied by OMIM, Nov 2010)

GeneCards Summary for ARHGDIG Gene:
ARHGDIG (Rho GDP dissociation inhibitor (GDI) gamma) is a protein-coding gene. GO annotations related to this gene include Rho GDP-dissociation inhibitor activity and GTPase activator activity. An important paralog of this gene is ARHGDIA.

UniProtKB/Swiss-Prot: GDIR3_HUMAN, Q99819
Function: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of
post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in
mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the
GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP

Gene Wiki entry for ARHGDIG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGDIG gene promoter:
         Lmo2   AP-2gamma   Evi-1   COMP1   AP-2beta   NF-Y   AP-2alpha   AP-2alphaA   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGDIG promoter sequence
   Search Chromatin IP Primers for ARHGDIG

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGDIG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

ARHGDIG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGDIG gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000318:  view genomic region     (about GC identifiers)

Start:
318,726 bp from pter      End:
333,003 bp from pter
Size:
14,278 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GDIR3_HUMAN, Q99819 (See protein sequence)
Recommended Name: Rho GDP-dissociation inhibitor 3  
Size: 225 amino acids; 25098 Da
Secondary accessions: Q4TT69 Q96S29

Explore the universe of human proteins at neXtProt for ARHGDIG: NX_Q99819

Explore proteomics data for ARHGDIG at MOPED


See ARHGDIG Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001167.2  
ENSEMBL proteins: 
 ENSP00000408037   ENSP00000397395   ENSP00000404435   ENSP00000219409   ENSP00000410541  
Reactome Protein details: Q99819

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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3 InterPro protein domains:
 IPR014756 Ig_E-set
 IPR024792 RhoGDI_domain
 IPR000406 Rho_GDI

Graphical View of Domain Structure for InterPro Entry Q99819

ProtoNet protein and cluster: Q99819

1 Blocks protein domain: IPB000406 RHO protein GDP dissociation inhibitor signature

UniProtKB/Swiss-Prot: GDIR3_HUMAN, Q99819
Similarity: Belongs to the Rho GDI family


Find genes that share domains with ARHGDIG           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: GDIR3_HUMAN, Q99819
Function: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of
post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in
mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the
GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP

     Genatlas biochemistry entry for ARHGDIG:
Rho GDP-dissociation inhibitor (GDI) gamma,preferentially expressed in brain and pancreas,binding to RHOA and
CDC42

     Gene Ontology (GO): 5 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005083small GTPase regulator activity ----
GO:0005092GDP-dissociation inhibitor activity ----
GO:0005094Rho GDP-dissociation inhibitor activity IEA--
GO:0005096GTPase activator activity IEA--
GO:0005515protein binding ----
     
Find genes that share ontologies with ARHGDIG           About GenesLikeMe


Phenotypes:
     2 GenomeRNAi human phenotypes for ARHGDIG:
 Altered focal adhesion (FA) or  Cell cycle / mitosis defect 

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Arhgdig):
 normal 

Find genes that share phenotypes with ARHGDIG           About GenesLikeMe

Animal Models:
     MGI mouse knock-out Arhgdigtm1Caw for ARHGDIG

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGDIG
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGDIG

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
GDIR3_HUMAN, Q99819: Cytoplasm
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol4
extracellular2
mitochondrion1
nucleus1

Gene Ontology (GO): 4 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005737cytoplasm ----
GO:0005829cytosol TAS--
GO:0016020membrane IEA--
GO:0016023cytoplasmic membrane-bounded vesicle TAS9113980

Find genes that share ontologies with ARHGDIG           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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SuperPaths for ARHGDIG About   (see all 12)  
See pathways by source

SuperPathContained pathways About
1Rho GTPase cycle
Rho GTPase cycle1.00
Signaling by Rho GTPases1.00
2Signaling by GPCR
Signal Transduction0.58
3Assembly of RNA Polymerase-II Initiation Complex
Crosstalk Between CARM1 and ESRs0.39
4Development HGF signaling pathway
Neurotrophin signaling pathway0.36
5RhoGDI Pathway
RhoGDI Pathway0.33


Find genes that share SuperPaths with ARHGDIG           About GenesLikeMe

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGDIG
    G12-G13 in Cellular Signaling
RhoGDI Pathway
Crosstalk Between CARM1 and ESRs

3 GeneGo (Thomson Reuters) Pathways for ARHGDIG
    G-protein signaling RhoB regulation pathway
G-protein signaling Regulation of CDC42 activity
G-protein signaling RhoA regulation pathway

2 BioSystems Pathways for ARHGDIG
    G13 Signaling Pathway
Regulation of RhoA activity

1 Reactome Pathway for ARHGDIG
    Rho GTPase cycle


2 Kegg Pathways  (Kegg details for ARHGDIG):
    Neurotrophin signaling pathway
Vasopressin-regulated water reabsorption

    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for ARHGDIG
Interactions:

    Search GeneGlobe Interaction Network for ARHGDIG

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for ARHGDIG (Q998193 ENSP000002194094) via UniProtKB, MINT, STRING, and/or I2D (see all 65)
InteractantInteraction Details
GeneCardExternal ID(s)
RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
RHOBP627453, ENSP000002722334I2D: score=2 STRING: ENSP00000272233
RHOGP840953, ENSP000003394674I2D: score=2 STRING: ENSP00000339467
RHOHQ156693, ENSP000003712194I2D: score=2 STRING: ENSP00000371219
CDC42P609533, ENSP000003144584I2D: score=2 STRING: ENSP00000314458
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Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0007162negative regulation of cell adhesion TAS9113980
GO:0007264small GTPase mediated signal transduction TAS--
GO:0007266Rho protein signal transduction TAS9113980
GO:0032880regulation of protein localization IEA--
GO:0050790regulation of catalytic activity TAS9113980

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for ARHGDIG (GDIR3)

2 HMDB Compounds for ARHGDIG    About this table
CompoundSynonyms CAS #PubMed Ids
Guanosine diphosphate5'-GDP (see all 10)146-91-8--
Guanosine triphosphate5'-GTP (see all 10)86-01-1--



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for ARHGDIG gene: 
NM_001176.3  

Unigene Cluster for ARHGDIG:

Rho GDP dissociation inhibitor (GDI) gamma
Hs.647388  [show with all ESTs]
Unigene Representative Sequence: BM472036
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000412541 ENST00000435035 ENST00000464609 ENST00000447871 ENST00000219409(uc002cgm.1)
ENST00000414650 ENST00000477621
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Additional mRNA sequence: 

AB593111.1 AF498928.1 BC047699.1 BC127922.1 U82532.1 

2 DOTS entries:

DT.105057  DT.95254004 

Selected AceView cDNA sequences (see all 60):

CB152764 BC000537 AI041729 CB152066 AK124931 NM_001176 AI369830 BM691552 
AF498928 AW135368 BC027964 CK906330 NM_006849 U19948 BV198796 Z84717 
BX110662 BI838005 BX643613 AA324789 BM709619 BM662457 BG152769 BM126892 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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ARHGDIG expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCCTGTCTC
ARHGDIG Expression
About this image


ARHGDIG expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 3) fully expand
 
 Brain (Nervous System)    fully expand to see all 9 entries
         Thalamus
 
 Pancreas (Endocrine System)
         Islets of Langerhans
 
 Testis (Reproductive System)
         Pre-Sertoli Cells Testis Cord
ARHGDIG Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

ARHGDIG Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.647388

UniProtKB/Swiss-Prot: GDIR3_HUMAN, Q99819
Tissue specificity: Primarily expressed in pancreas and brain

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGDIG gene from Selected species (see all 14)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Arhgdig1 , 5 Rho GDP dissociation inhibitor (GDI) gamma1, 5 81.93(n)1
79.56(a)1
  17 (13.07 cM)5
145701  NM_008113.31  NP_032139.11 
 261962265 
chicken
(Gallus gallus)
Aves ARHGDIG1 Rho GDP dissociation inhibitor (GDI) gamma 74.96(n)
66.22(a)
  100858938  XM_003642163.2  XP_003642211.1 
tropical clawed frog
(Xenopus tropicalis)
Amphibia arhgdig1 Rho GDP dissociation inhibitor (GDI) gamma 61.98(n)
59.3(a)
  493242  NM_001007515.1  NP_001007516.1 
zebrafish
(Danio rerio)
Actinopterygii arhgdig6
Rho GDP dissociation inhibitor (GDI) gamma
60(a)
1 ↔ 1
3(27864729-27920351) ENSDARG00000004034
fruit fly
(Drosophila melanogaster)
Insecta RhoGDI6
RhoGDI
43(a)
1 → many
3L(19921843-19926030)
worm
(Caenorhabditis elegans)
Secernentea rhi-16
Protein RHI-1 (rhi-1) mRNA, complete cds
37(a)
1 → many
X(4508509-4510960) WBGene00004356
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDI16
Rho GDP dissociation inhibitor involved in the loc...
34(a)
1 → many
IV(218680-219288) YDL135C


ENSEMBL Gene Tree for ARHGDIG (if available)
TreeFam Gene Tree for ARHGDIG (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for ARHGDIG gene
ARHGDIA2  ARHGDIB2  
2 SIMAP similar genes for ARHGDIG using alignment to 9 protein entries:     GDIR3_HUMAN (see all proteins):
ARHGDIA    ARHGDIB

Find genes that share paralogs with ARHGDIG           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for ARHGDIG (see all 44)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 16 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1901158251,2
--328790(+) CTAACA/GTAGTG 1 -- us2k10--------
rs22383711,2
C,F,H--328916(+) ATGCCC/GCACAC 1 -- us2k18Minor allele frequency- G:0.04EA NS NA 2156
rs799822661,2
C,F--329097(+) TGGCTG/ACTGTG 1 -- us2k11Minor allele frequency- A:0.09WA 118
rs779220681,2
C,F--329102(+) GCTGTG/AATAAC 1 -- us2k11Minor allele frequency- A:0.03EA 120
rs286139721,2
C,F--329129(+) CTTCAC/TCTCTG 1 -- us2k11Minor allele frequency- T:0.13WA 118
rs558595001,2
C,F--329138(+) TGATTG/TGTCTC 1 -- us2k15Minor allele frequency- T:0.25WA CSA NA 242
rs1480605081,2
C--329144(+) GTCTCA/GGGCCA 1 -- us2k10--------
rs4489711,2
C,F,A,H--329211(-) CAAAGA/GAACCT 1 -- us2k121Minor allele frequency- G:0.37NS EA NA WA CSA 2346
rs1136457321,2
F--329297(+) GTTAAG/ATCTGT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
rs1416260651,2
--329380(+) TTTTGC/TTCAAT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for ARHGDIG (318726 - 333003 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for ARHGDIG (see all 14):    About this table    
Variant IDTypeSubtypePubMed ID
esv2422427CNV Duplication17116639
nsv904690CNV Loss21882294
nsv904674CNV Loss21882294
dgv2465n71CNV Loss21882294
dgv2470n71CNV Loss21882294
nsv904677CNV Loss21882294
dgv2458n71CNV Loss21882294
dgv2469n71CNV Loss21882294
dgv32n68CNV Loss17160897
dgv2468n71CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 602844    OMIM disorders: --


Find genes that share disorders with ARHGDIG           About GenesLikeMe

Genetic Association Database (GAD): ARHGDIG
Human Genome Epidemiology (HuGE) Navigator: ARHGDIG (1 document)

Export disorders for ARHGDIG gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for ARHGDIG gene, integrated from 10 sources (see all 14):
(articles sorted by number of sources associating them with ARHGDIG)
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  1. RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. (PubMed id 9113980)1, 2, 3 Adra C.N.... Lim B. (Proc. Natl. Acad. Sci. U.S.A. 1997)
  2. Application of gene network analysis techniques identifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve. (PubMed id 20098615)1, 4 Wooten E.C....Huggins G.S. (PLoS ONE 2010)
  3. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain. (PubMed id 11967128)1, 3 Brunet N....Olofsson B. (Traffic 2002)
  6. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (Hum. Mol. Genet. 2001)
  7. Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3. (PubMed id 9787082)1, 2 Adra C.N.... Higgs D.R. (Genomics 1998)
  8. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
  9. Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors. (PubMed id 15513926)1 Dransart E....Olofsson B. (J. Biol. Chem. 2005)
  10. Integrins regulate Rac targeting by internalization of membrane domains. (PubMed id 14764880)1 del Pozo M.A....Schwartz M.A. (Science 2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 398 HGNC: 680 AceView: ARHGDIG Ensembl:ENSG00000242173 euGenes: HUgn398
ECgene: ARHGDIG Kegg: 398 H-InvDB: ARHGDIG

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for ARHGDIG Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for ARHGDIG gene:
Search GeneIP for patents involving ARHGDIG

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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