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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGDIG Gene

protein-coding   GIFtS: 56
GCID: GC16P000318

Rho GDP Dissociation Inhibitor (GDI) Gamma

  Search for ARHGDIG
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho GDP Dissociation Inhibitor (GDI) Gamma1 2
RhoGDI Gamma1 2
Rho GDI 32 3
Rho-GDI Gamma2 3
RHOGDI-32
Rho GDP-Dissociation Inhibitor 32

External Ids:    HGNC: 6801   Entrez Gene: 3982   Ensembl: ENSG000002421737   OMIM: 6028445   UniProtKB: Q998193   

Export aliases for ARHGDIG gene to outside databases

Previous GC identifers: GC16P000349 GC16P000270 GC16P000250


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGDIG Gene:
The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting
the exchange of GDP for GTP. See ARHGDIB (MIM 602843).(supplied by OMIM, Nov 2010)

GeneCards Summary for ARHGDIG Gene: 
ARHGDIG (Rho GDP dissociation inhibitor (GDI) gamma) is a protein-coding gene. Among its related super-pathways are Signaling by Rho GTPases and Signaling by GPCR. GO annotations related to this gene include Rho GDP-dissociation inhibitor activity and GTPase activator activity. An important paralog of this gene is ARHGDIA.

UniProtKB/Swiss-Prot: GDIR3_HUMAN, Q99819
Function: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of
post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in
mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the
GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP

Gene Wiki entry for ARHGDIG Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGDIG gene promoter:
         Lmo2   AP-2gamma   Evi-1   COMP1   AP-2beta   NF-Y   AP-2alpha   AP-2alphaA   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGDIG promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGDIG

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGDIG


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   HGNC cytogenetic band: 16p13.3

ARHGDIG Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGDIG gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P000318:  view genomic region     (about GC identifiers)

Start:
318,726 bp from pter      End:
333,003 bp from pter
Size:
14,278 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GDIR3_HUMAN, Q99819 (See protein sequence)
Recommended Name: Rho GDP-dissociation inhibitor 3  
Size: 225 amino acids; 25098 Da
Subcellular location: Cytoplasm
Secondary accessions: Q4TT69 Q96S29

Explore the universe of human proteins at neXtProt for ARHGDIG: NX_Q99819

Explore proteomics data for ARHGDIG at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q99819

  • ARHGDIG Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGDIG Protein Expression
    REFSEQ proteins: NP_001167.2  
    ENSEMBL proteins: 
     ENSP00000408037   ENSP00000397395   ENSP00000404435   ENSP00000219409   ENSP00000410541  
    Reactome Protein details: Q99819
    Human Recombinant Protein Products for ARHGDIG: 
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    Novus Biologicals ARHGDIG Protein
    Novus Biologicals ARHGDIG Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0016020membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle TAS9113980

    ARHGDIG for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR024792 RhoGDI_domain
     IPR000406 Rho_GDI

    Graphical View of Domain Structure for InterPro Entry Q99819

    ProtoNet protein and cluster: Q99819

    1 Blocks protein domain: IPB000406 RHO protein GDP dissociation inhibitor signature

    UniProtKB/Swiss-Prot: GDIR3_HUMAN, Q99819
    Similarity: Belongs to the Rho GDI family


    ARHGDIG for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GDIR3_HUMAN, Q99819
    Function: Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of
    post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in
    mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the
    GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP

         Genatlas biochemistry entry for ARHGDIG:
    Rho GDP-dissociation inhibitor (GDI) gamma,preferentially expressed in brain and pancreas,binding to RHOA and
    CDC42

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005083small GTPase regulator activity ----
    GO:0005092GDP-dissociation inhibitor activity ----
    GO:0005094Rho GDP-dissociation inhibitor activity IEA--
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding ----
         
    ARHGDIG for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGDIG:
     Altered focal adhesion (FA) or  Cell cycle / mitosis defect 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Arhgdig):
     normal 

    ARHGDIG for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arhgdigtm1Caw for ARHGDIG

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGDIG 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARHGDIG

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGDIG 
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    miRNA
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGDIG


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGDIG About   (see all 12)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    2Signaling by GPCR
    Signal Transduction0.55
    3G-protein signaling RhoB regulation pathway
    G-protein signaling RhoB regulation pathway1.00
    4G-protein signaling Regulation of CDC42 activity
    G-protein signaling Regulation of CDC42 activity1.00
    5G-protein signaling RhoA regulation pathway
    G-protein signaling RhoA regulation pathway1.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for ARHGDIG
        G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoB regulation pathway
    G-protein signaling RhoA regulation pathway

    3 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGDIG
        G12-G13 in Cellular Signaling
    RhoGDI Pathway
    Crosstalk Between CARM1 and ESRs

    3 GeneGo (Thomson Reuters) Pathways for ARHGDIG
        G-protein signaling RhoB regulation pathway
    G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway

    2 BioSystems Pathways for ARHGDIG
        G13 Signaling Pathway
    Regulation of RhoA activity

    3        Reactome Pathways for ARHGDIG
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle


    2         Kegg Pathways  (Kegg details for ARHGDIG):
        Neurotrophin signaling pathway
    Vasopressin-regulated water reabsorption


    ARHGDIG for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for ARHGDIG

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/52 Interacting proteins for ARHGDIG (Q998193 ENSP000002194094) via UniProtKB, MINT, STRING, and/or I2D (see all 52)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RHOAP615863, ENSP000004001754I2D: score=2 STRING: ENSP00000400175
    RHOBP627453, ENSP000002722334I2D: score=2 STRING: ENSP00000272233
    RHOGP840953, ENSP000003394674I2D: score=2 STRING: ENSP00000339467
    RHOHQ156693, ENSP000003712194I2D: score=2 STRING: ENSP00000371219
    CDC42P609533, ENSP000003144584I2D: score=2 STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007162negative regulation of cell adhesion TAS9113980
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction TAS9113980
    GO:0032880regulation of protein localization IEA--
    GO:0051056regulation of small GTPase mediated signal transduction TAS--

    ARHGDIG for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for ARHGDIG (GDIR3)

    2 HMDB Compounds for ARHGDIG    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about ARHGDIG / GDIR3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGDIG gene: 
    NM_001176.3  

    Unigene Cluster for ARHGDIG:

    Rho GDP dissociation inhibitor (GDI) gamma
    Hs.647388  [show with all ESTs]
    Unigene Representative Sequence: BM472036
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412541 ENST00000435035 ENST00000464609 ENST00000447871 ENST00000219409(uc002cgm.1)
    ENST00000414650 ENST00000477621
    miRNA
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    Additional mRNA sequence: 

    AB593111.1 AF498928.1 BC047699.1 BC127922.1 U82532.1 

    2 DOTS entries:

    DT.105057  DT.95254004 

    24/60 AceView cDNA sequences (see all 60):

    AF498928 BC027964 CB152764 CB152066 BM691552 AI369830 AK124931 NM_001176 
    BC000537 AW135368 AI041729 U19948 BX110662 BM709619 BM126892 U82532 
    BI836238 AA323150 CK906330 BM126625 H21176 AA324789 AA835148 BI916423 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGDIG expression in normal human tissues (normalized intensities)      ARHGDIG embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCCTGTCTC
    ARHGDIG Expression
    About this image


    ARHGDIG expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/7 selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 19 entries
             Thalamus
             Septum   
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             reticulocytes   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Testis (Reproductive System)
             Pre-Sertoli Cells Testis Cord

    See ARHGDIG Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGDIG

    SOURCE GeneReport for Unigene cluster: Hs.647388

    UniProtKB/Swiss-Prot: GDIR3_HUMAN, Q99819
    Tissue specificity: Primarily expressed in pancreas and brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGDIG

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGDIG gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgdig1 , 5 Rho GDP dissociation inhibitor (GDI) gamma1, 5 81.93(n)1
    79.56(a)1
      17 (13.07 cM)5
    145701  NM_008113.31  NP_032139.11 
     261962265 
    chicken
    (Gallus gallus)
    Aves LOC1008589381 rho GDP-dissociation inhibitor 3-like 74.96(n)
    66.22(a)
      100858938  XM_003642163.1  XP_003642211.1 
    zebrafish
    (Danio rerio)
    Actinopterygii arhgdig6
    Rho GDP dissociation inhibitor (GDI) gamma
    58(a)
    1 ↔ 1
    3(27864729-27920351)
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGDI6
    RhoGDI
    42(a)
    1 → many
    3L(19921843-19926030)
    worm
    (Caenorhabditis elegans)
    Secernentea rhi-16
    Probable rho GDP-dissociation inhibitor
    35(a)
    1 → many
    X(4508507-4510963)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RDI16
    Rho GDP dissociation inhibitor involved in the loc...
    32(a)
    1 → many
    IV(218680-219288)


    ENSEMBL Gene Tree for ARHGDIG (if available)
    TreeFam Gene Tree for ARHGDIG (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGDIG gene
    ARHGDIA2  ARHGDIB2  
    2 SIMAP similar genes for ARHGDIG using alignment to 9 protein entries:     GDIR3_HUMAN (see all proteins):
    ARHGDIA    ARHGDIB

    ARHGDIG for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/44 SNPs in ARHGDIG are shown (see all 44)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1901158251,2
    --328790(+) CTAACA/GTAGTG 1 -- us2k10--------
    rs22383711,2
    C,F,H--328916(+) ATGCCC/GCACAC 1 -- us2k18Minor allele frequency- G:0.04EA NS NA 2156
    rs799822661,2
    C,F--329097(+) TGGCTG/ACTGTG 1 -- us2k11Minor allele frequency- A:0.09WA 118
    rs779220681,2
    C,F--329102(+) GCTGTG/AATAAC 1 -- us2k11Minor allele frequency- A:0.03EA 120
    rs286139721,2
    C,F--329129(+) CTTCAC/TCTCTG 1 -- us2k11Minor allele frequency- T:0.13WA 118
    rs558595001,2
    C,F--329138(+) TGATTG/TGTCTC 1 -- us2k15Minor allele frequency- T:0.25WA CSA NA 242
    rs1480605081,2
    C--329144(+) GTCTCA/GGGCCA 1 -- us2k10--------
    rs4489711,2
    C,F,A,H--329211(-) CAAAGA/GAACCT 1 -- us2k121Minor allele frequency- G:0.37NS EA NA WA CSA 2346
    rs1136457321,2
    F--329297(+) GTTAAG/ATCTGT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1416260651,2
    --329380(+) TTTTGC/TTCAAT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for ARHGDIG (318726 - 333003 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for ARHGDIG (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422427CNV Duplication17116639
    nsv904690CNV Loss21882294
    nsv904674CNV Loss21882294
    dgv2465n71CNV Loss21882294
    dgv2470n71CNV Loss21882294
    nsv904677CNV Loss21882294
    dgv2458n71CNV Loss21882294
    dgv2469n71CNV Loss21882294
    dgv32n68CNV Loss17160897
    dgv2468n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    ARHGDIG for disorders           About MalaCards
    OMIM gene information: 602844    OMIM disorders: --


    ARHGDIG for disorders           About GeneDecksing

    Genetic Association Database (GAD): ARHGDIG
    Human Genome Epidemiology (HuGE) Navigator: ARHGDIG (1 document)

    Export disorders for ARHGDIG gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGDIG gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with ARHGDIG)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. (PubMed id 9113980)1, 2, 3 Adra C.N.... Lim B. (1997)
    2. Application of gene network analysis techniques ident ifies AXIN1/PDIA2 and endoglin haplotypes associated with bicuspid aortic valve . (PubMed id 20098615)1, 4 Wooten E.C....Huggins G.S. (2010)
    3. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain. (PubMed id 11967128)1, 3 Brunet N....Olofsson B. (2002)
    6. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PubMed id 11157797)1, 2 Daniels R.J....Higgs D.R. (2001)
    7. Human ARHGDIG, a GDP-dissociation inhibitor for Rho proteins: genomic structure, sequence, expression analysis, and mapping to chromosome 16p13.3. (PubMed id 9787082)1, 2 Adra C.N.... Higgs D.R. (1998)
    8. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
    9. Uncoupling of inhibitory and shuttling functions of rho GDP dissociation inhibitors. (PubMed id 15513926)1 Dransart E....Olofsson B. (2005)
    10. Integrins regulate Rac targeting by internalization of membrane domains. (PubMed id 14764880)1 del Pozo M.A....Schwartz M.A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 398 HGNC: 680 AceView: ARHGDIG Ensembl:ENSG00000242173 euGenes: HUgn398
    ECgene: ARHGDIG Kegg: 398 H-InvDB: ARHGDIG

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGDIG Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGDIG gene:
    Search GeneIP for patents involving ARHGDIG

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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