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Aliases for ARHGDIG Gene

Aliases for ARHGDIG Gene

  • Rho GDP Dissociation Inhibitor Gamma 2 3
  • Rho GDP Dissociation Inhibitor (GDI) Gamma 2 3 5
  • Rho-GDI Gamma 3 4
  • RhoGDI Gamma 2 3
  • Rho GDI 3 3 4
  • RHOGDI-3 3

External Ids for ARHGDIG Gene

Previous GeneCards Identifiers for ARHGDIG Gene

  • GC16P000349
  • GC16P000270
  • GC16P000318
  • GC16P000250
  • GC16P000279
  • GC16P000308

Summaries for ARHGDIG Gene

Entrez Gene Summary for ARHGDIG Gene

  • The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP. See ARHGDIB (MIM 602843).[supplied by OMIM, Nov 2010]

GeneCards Summary for ARHGDIG Gene

ARHGDIG (Rho GDP Dissociation Inhibitor Gamma) is a Protein Coding gene. Among its related pathways are Development HGF signaling pathway and Vasopressin-regulated water reabsorption. GO annotations related to this gene include GTPase activator activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIA.

UniProtKB/Swiss-Prot for ARHGDIG Gene

  • Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.

Gene Wiki entry for ARHGDIG Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGDIG Gene

Genomics for ARHGDIG Gene

Regulatory Elements for ARHGDIG Gene

Enhancers for ARHGDIG Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around ARHGDIG on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGDIG Gene

Chromosome:
16
Start:
268,727 bp from pter
End:
283,010 bp from pter
Size:
14,284 bases
Orientation:
Plus strand

Genomic View for ARHGDIG Gene

Genes around ARHGDIG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGDIG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGDIG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGDIG Gene

Proteins for ARHGDIG Gene

  • Protein details for ARHGDIG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99819-GDIR3_HUMAN
    Recommended name:
    Rho GDP-dissociation inhibitor 3
    Protein Accession:
    Q99819
    Secondary Accessions:
    • Q4TT69
    • Q96S29

    Protein attributes for ARHGDIG Gene

    Size:
    225 amino acids
    Molecular mass:
    25098 Da
    Quaternary structure:
    No Data Available

neXtProt entry for ARHGDIG Gene

Proteomics data for ARHGDIG Gene at MOPED

Post-translational modifications for ARHGDIG Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for ARHGDIG Gene

No data available for DME Specific Peptides for ARHGDIG Gene

Domains & Families for ARHGDIG Gene

Protein Domains for ARHGDIG Gene

Graphical View of Domain Structure for InterPro Entry

Q99819

UniProtKB/Swiss-Prot:

GDIR3_HUMAN :
  • Belongs to the Rho GDI family.
Family:
  • Belongs to the Rho GDI family.
genes like me logo Genes that share domains with ARHGDIG: view

No data available for Gene Families for ARHGDIG Gene

Function for ARHGDIG Gene

Molecular function for ARHGDIG Gene

GENATLAS Biochemistry:
Rho GDP-dissociation inhibitor (GDI) gamma,preferentially expressed in brain and pancreas,binding to RHOA and CDC42
UniProtKB/Swiss-Prot Function:
Inhibits GDP/GTP exchange reaction of RhoB. Interacts specifically with the GDP- and GTP-bound forms of post-translationally processed Rhob and Rhog proteins, both of which show a growth-regulated expression in mammalian cells. Stimulates the release of the GDP-bound but not the GTP-bound RhoB protein. Also inhibits the GDP/GTP exchange of RhoB but shows less ability to inhibit the dissociation of prebound GTP.

Gene Ontology (GO) - Molecular Function for ARHGDIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with ARHGDIG: view
genes like me logo Genes that share phenotypes with ARHGDIG: view

Animal Models for ARHGDIG Gene

MGI Knock Outs for ARHGDIG:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for ARHGDIG Gene

Localization for ARHGDIG Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGDIG Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGDIG Gene COMPARTMENTS Subcellular localization image for ARHGDIG gene
Compartment Confidence
cytosol 5
extracellular 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for ARHGDIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with ARHGDIG: view

Pathways & Interactions for ARHGDIG Gene

genes like me logo Genes that share pathways with ARHGDIG: view

Gene Ontology (GO) - Biological Process for ARHGDIG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0032880 regulation of protein localization IEA --
GO:0050790 regulation of catalytic activity IEA --
GO:0051056 regulation of small GTPase mediated signal transduction TAS --
genes like me logo Genes that share ontologies with ARHGDIG: view

No data available for SIGNOR curated interactions for ARHGDIG Gene

Drugs & Compounds for ARHGDIG Gene

(2) Drugs for ARHGDIG Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with ARHGDIG: view

Transcripts for ARHGDIG Gene

Unigene Clusters for ARHGDIG Gene

Rho GDP dissociation inhibitor (GDI) gamma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIG Gene

No ASD Table

Relevant External Links for ARHGDIG Gene

GeneLoc Exon Structure for
ARHGDIG
ECgene alternative splicing isoforms for
ARHGDIG

Expression for ARHGDIG Gene

mRNA expression in normal human tissues for ARHGDIG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGDIG Gene

This gene is overexpressed in Brain - Cortex (x6.1), Brain - Cerebellum (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.4), Brain - Frontal Cortex (BA9) (x5.1), and Brain - Cerebellar Hemisphere (x4.7).

Protein differential expression in normal tissues from HIPED for ARHGDIG Gene

This gene is overexpressed in Tlymphocyte (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for ARHGDIG Gene



SOURCE GeneReport for Unigene cluster for ARHGDIG Gene Hs.647388

mRNA Expression by UniProt/SwissProt for ARHGDIG Gene

Q99819-GDIR3_HUMAN
Tissue specificity: Primarily expressed in pancreas and brain.
genes like me logo Genes that share expression patterns with ARHGDIG: view

Protein tissue co-expression partners for ARHGDIG Gene

Primer Products

Orthologs for ARHGDIG Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGDIG Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARHGDIG 35
  • 86.76 (n)
  • 85.27 (a)
ARHGDIG 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia ARHGDIG 35
  • 83.66 (n)
  • 80.88 (a)
ARHGDIG 36
  • 74 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgdig 35
  • 81.93 (n)
  • 79.56 (a)
Arhgdig 16
Arhgdig 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia ARHGDIG 35
  • 98.84 (n)
  • 99 (a)
ARHGDIG 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgdig 35
  • 82.67 (n)
  • 81.78 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGDIG 36
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGDIG 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGDIG 35
  • 74.96 (n)
  • 66.22 (a)
ARHGDIG 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgdig 35
  • 61.98 (n)
  • 59.3 (a)
zebrafish
(Danio rerio)
Actinopterygii arhgdig 36
  • 60 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta RhoGDI 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rhi-1 36
  • 37 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDI1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
OneToMany
Species with no ortholog for ARHGDIG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGDIG Gene

ENSEMBL:
Gene Tree for ARHGDIG (if available)
TreeFam:
Gene Tree for ARHGDIG (if available)

Paralogs for ARHGDIG Gene

Paralogs for ARHGDIG Gene

(2) SIMAP similar genes for ARHGDIG Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with ARHGDIG: view

Variants for ARHGDIG Gene

Sequence variations from dbSNP and Humsavar for ARHGDIG Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs369440 -- 280,925(+) GGGGA(A/G)GGGAC intron-variant
rs373271 -- 279,671(+) AGCTC(C/T)TTGGC upstream-variant-2KB
rs421123 -- 279,578(-) CACAA(C/T)CTTTC upstream-variant-2KB
rs448971 -- 279,211(-) CAAAG(A/G)AACCT upstream-variant-2KB
rs62032216 -- 279,463(+) TGGAG(A/C)TGTGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARHGDIG Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2458n71 CNV Loss 21882294
nsv904652 CNV Loss 21882294
dgv32n68 CNV Loss 17160897
dgv2465n71 CNV Loss 21882294
dgv2466n71 CNV Loss 21882294
nsv904674 CNV Loss 21882294
nsv827477 CNV Gain 20364138
dgv2467n71 CNV Loss 21882294
nsv904677 CNV Loss 21882294
dgv2468n71 CNV Loss 21882294
dgv2469n71 CNV Loss 21882294
dgv2470n71 CNV Loss 21882294
nsv904690 CNV Loss 21882294

Variation tolerance for ARHGDIG Gene

Residual Variation Intolerance Score: 78.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 15.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGDIG Gene

HapMap Linkage Disequilibrium report
ARHGDIG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGDIG Gene

Disorders for ARHGDIG Gene

Relevant External Links for ARHGDIG

Genetic Association Database (GAD)
ARHGDIG
Human Genome Epidemiology (HuGE) Navigator
ARHGDIG
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGDIG

No disorders were found for ARHGDIG Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGDIG Gene

Publications for ARHGDIG Gene

  1. RhoGDIgamma: a GDP-dissociation inhibitor for Rho proteins with preferential expression in brain and pancreas. (PMID: 9113980) Adra C.N. … Lim B. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 67
  2. RhoGDI-3 regulates RhoG and targets this protein to the Golgi complex through its unique N-terminal domain. (PMID: 11967128) Brunet N. … Olofsson B. (Traffic 2002) 2 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PMID: 21697133) Oshikawa M. … Kato S. (Invest. Ophthalmol. Vis. Sci. 2011) 3

Products for ARHGDIG Gene

Sources for ARHGDIG Gene

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