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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGDIB Gene

protein-coding   GIFtS: 65
GCID: GC12M015094

Rho GDP dissociation inhibitor (GDI) beta


(Previous symbols: RAP1GN1, GDIA2, GDID4)
 Explore 14 diseases affiliated with
ARHGDIB via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for ARHGDIB    

Aliases
for ARHGDIB gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Rho GDP Dissociation Inhibitor (GDI) Beta1 2     Rho-GDI Beta2 3
GDID41 2 3 5     Rho GDI 22 3
GDIA21 2 3     D42 5
Ly-GDI1 2 3     LYGDI2
RAP1GN11 2 3     Rho GDP-Dissociation Inhibitor 22
RhoGDI21 2     

External Ids:    HGNC: 6791   Entrez Gene: 3972   Ensembl: ENSG000001113487   OMIM: 6028435   UniProtKB: P525663   

Export aliases for ARHGDIB gene to outside databases

Previous GC identifers: GC12M014834 GC12M015239 GC12M014995 GC12M014986 GC12M014864


Summaries
for ARHGDIB gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for ARHGDIB:
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM
179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization,
and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly
regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine
nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the
rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 (PubMed 8356058)).(supplied by OMIM,
Dec 2010)

UniProtKB/Swiss-Prot: GDIR2_HUMAN, P52566
Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them,
and the subsequent binding of GTP to them

Gene Wiki entry for ARHGDIB


Genomic Views
for ARHGDIB gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_009714.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGDIB gene promoter:
         AML1a   Pbx1a   STAT5A   PPAR-gamma1   S8   Nkx6-1   HFH-1   ARP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: ARHGDIB promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGDIB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGDIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

ARHGDIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGDIB gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M015094:  view genomic region     (about GC identifiers)

Start:
 15,094,950 bp from pter      End:
 15,114,662 bp from pter
Size:
 19,713 bases      Orientation:
 minus strand

Proteins
for ARHGDIB gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: GDIR2_HUMAN, P52566 (See protein sequence)
Recommended Name: Rho GDP-dissociation inhibitor 2  
Size: 201 amino acids; 22988 Da
Subcellular location: Cytoplasm
1 PDB 3D structure from and Proteopedia for ARHGDIB:
1DS6 (3D)    
Secondary accessions: B5BU79

Explore the universe of human proteins at neXtProt for ARHGDIB: NX_P52566

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P52566

    • ARHGDIB Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001166.3  
    ENSEMBL proteins: 
     ENSP00000228945   ENSP00000445185   ENSP00000444860   ENSP00000440560   ENSP00000445263  
     ENSP00000437454   ENSP00000445450  
    Reactome Protein details: P52566
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for ARHGDIB
    Browse Proteins at Uscn

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS16130169
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169
    GO:0016023cytoplasmic membrane-bounded vesicle TAS9113980


    ARHGDIB for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for ARHGDIB gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    ARHGDIB for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR014756 Ig_E-set
     IPR024792 RhoGDI_domain
     IPR000406 Rho_GDI

    Graphical View of Domain Structure for InterPro Entry P52566

    ProtoNet protein and cluster: P52566

    1 Blocks protein family: IPB000406 RHO protein GDP dissociation inhibitor signature

    UniProtKB/Swiss-Prot: GDIR2_HUMAN, P52566
    Similarity: Belongs to the Rho GDI family


    Function
    for ARHGDIB gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: GDIR2_HUMAN, P52566
    Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them,
    and the subsequent binding of GTP to them

         Genatlas biochemistry entry for ARHGDIB:
    Rho GDP-dissociation inhibitor (GDI) beta,aplysia related,preferentially expressed in hematopoietic cells (signal
    transduction)

    miRNA
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    hsa-miR-582-5p hsa-miR-1321 hsa-miR-3156-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ARHGDIB 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005094Rho GDP-dissociation inhibitor activity IEA--
    GO:0005096GTPase activator activity IEA--


    ARHGDIB for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for ARHGDIB:
     Increased cilium length after  

    Animal Models:
         Mouse knock-outs for ARHGDIB: Arhgdibtm1Len Arhgdibtm1Miyo
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Arhgdib):
     cellular  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system 
     mortality/aging  reproductive system 

    ARHGDIB for phenotypes           About GeneDecksing


    Pathways & Interactions
    for ARHGDIB gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/17 super-pathways (see all 17) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1G-protein signaling Regulation of RAC1 activity
    		G-protein signaling Regulation of RAC1 activity1.00
    		G-protein signaling Regulation of CDC42 activity0.25
    		G-protein signaling_Regulation of RAC1 activity0.88
    		G-protein signaling_Regulation of CDC42 activity0.25
    2G-protein signaling_RhoA regulation pathway
    		G-protein signaling_RhoA regulation pathway1.00
    		G-protein signaling RhoA regulation pathway1.00
    3Actin Nucleation by ARP-WASP Complex
    		Actin Nucleation by ARP-WASP Complex1.00
    		RhoA Pathway0.35
    4Apoptosis and survival_Caspase cascade
    		Caspase cascade in apoptosis0.42
    		FAS pathway and Stress induction of HSP regulation0.33
    5TWEAK Pathway
    		Apoptosis through Death Receptors0.32
    		Fas Signaling0.29

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for ARHGDIB
        G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway
    G-protein signaling Regulation of RAC1 activity

    5/10 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGDIB (see all 10)
        Caspase Cascade
    RhoA Pathway
    Actin-Based Motility by Rho Family GTPases
    G12-G13 in Cellular Signaling
    Fas Signaling

    3 GeneGo (Thomson Reuters) Pathways for ARHGDIB
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway

    4 BioSystems Pathways for ARHGDIB 
        G13 Signaling Pathway
    FAS pathway and Stress induction of HSP regulation
    Caspase cascade in apoptosis
    Regulation of RhoA activity

    3        Reactome Pathways for ARHGDIB
        Signaling by Rho GTPases
    Signal Transduction
    Rho GTPase cycle


    2         Kegg Pathways  (Kegg details for ARHGDIB):
        Neurotrophin signaling pathway
    Vasopressin-regulated water reabsorption


    ARHGDIB for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGDIB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/67 Interacting proteins for ARHGDIB (P525662, 3 ENSP000002289454) via UniProtKB, MINT, STRING, and/or I2D (see all 67)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC2P151532, 3, ENSP000002490714MINT-16596 MINT-24949 I2D: score=5 STRING: ENSP00000249071
    RAC1P630002, 3, ENSP000003484614MINT-8267885 I2D: score=4 STRING: ENSP00000348461
    RAC3P607632, 3, ENSP000003042834MINT-8267940 I2D: score=3 STRING: ENSP00000304283
    UFM1P619602, 3, ENSP000002398784MINT-8276883 I2D: score=2 STRING: ENSP00000239878
    RHOAP615863, ENSP000004001754I2D: score=3 STRING: ENSP00000400175
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS16130169
    GO:0006955immune response TAS8356058
    GO:0007162negative regulation of cell adhesion TAS9113980
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction TAS8356058


    ARHGDIB for ontologies           About GeneDecksing



    Drugs & Compounds
    for ARHGDIB gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARHGDIB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARHGDIB

    2 HMDB Compounds for ARHGDIB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    3 Novoseek chemical compound relationships for ARHGDIB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 78.1 5 7512369 (1), 15057873 (1), 8356058 (1), 18006811 (1) (see all 5)
    gtp 50.3 1 8356058 (1)
    tyrosine 10.5 2 10664460 (1), 12386169 (1)

    Search CenterWatch for drugs/clinical trials and news about ARHGDIB / GDIR2 

    Transcripts
    for ARHGDIB gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for ARHGDIB gene: 
    NM_001175.4  

    Unigene Cluster for ARHGDIB:

    Rho GDP dissociation inhibitor (GDI) beta
    Hs.504877  [show with all ESTs]
    Unigene Representative Sequence: AK125625
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228945(uc001rcq.1) ENST00000536592 ENST00000541644 ENST00000539131
    ENST00000541546 ENST00000545895 ENST00000535676 ENST00000541380 ENST00000542276


    miRNA
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    hsa-miR-582-5p hsa-miR-1321 hsa-miR-3156-5p
    SwitchGear 3'UTR luciferase reporter plasmid: ARHGDIB 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AB451315.1 AB451445.1 AF498927.1 AK125625.1 AK311807.1 BC009200.2 L07916.1 L20688.1 
    X69549.1 

    24/34 DOTS entries (see all 34):

    DT.100060471  DT.91847582  DT.91970763  DT.91793426  DT.92361848  DT.100678779  DT.100678784  DT.92380919 
    DT.75107035  DT.97765236  DT.100678782  DT.95271574  DT.121189599  DT.101967391  DT.91984917  DT.91769961 
    DT.100678780  DT.100871202  DT.80101095  DT.91769947  DT.95271572  DT.100049413  DT.121189624  DT.121189654 

    24/1002 AceView cDNA sequences (see all 1002):

    BG231855 AW327888 AW574654 AA962516 AA699606 AA309545 BQ688932 AW575363 
    W94362 AA282251 BQ128224 AI819959 BU069955 AA352794 AW575601 AI193288 
    CR610137 AI188740 AW075884 CA427002 AA477190 AI147881 AA875928 BM662758 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIB (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
    SP1:                                -     -     -     -     -                       -           -                                       
    SP2:                                -     -     -     -     -                       -           -                                       
    SP3:                                -           -     -     -                       -           -                                       
    SP4:                                -     -     -     -     -                       -           -                                       
    SP5:                                -     -     -     -     -                       -           -                                       


    ECgene alternative splicing isoforms for ARHGDIB

    Expression
    for ARHGDIB gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGDIB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CTGGCGCGAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    ARHGDIB expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See ARHGDIB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGDIB

    SOURCE GeneReport for Unigene cluster: Hs.504877
        SABiosciences Expression via Pathway-Focused PCR Arrays including ARHGDIB: 
              Cytoskeleton Regulators in human mouse rat
              TNF Ligands & Receptors in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGDIB
    In Situ
    Assay Products:     
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    Orthologs
    for ARHGDIB gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARHGDIB gene from 9/26 species (see all 26)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Arhgdib1 , 5 Rho, GDP dissociation inhibitor (GDI) beta1, 5 84.17(n)1
    88(a)1    		   6 (66.72 cM)5
    118571  NM_007486.41  NP_031512.11 
     1369235235 
    chicken
    (Gallus gallus)    		 Aves ARHGDIB1 Rho GDP dissociation inhibitor (GDI) beta 82.5(n)
    92(a)    		   417941  XM_416182.3  XP_416182.1 
    lizard
    (Anolis carolinensis)    		 Reptilia ARHGDIB6
    		 --
    		 86(a)
    		 1 ↔ 1
    		 5(27794455-27803171)
    African clawed frog
    (Xenopus laevis)    		 Amphibia arhgdib-prov2 Rho GDP dissociation inhibitor (GDI) beta 75.09(n)    BC056079.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc659662 similar to Rho GDP dissociation inhibitor (GDI) beta 75.02(n)   394132  BC056296.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta RhoGDI3 Rho GDP-dissociation inhibitor 50(a)   76D5   --
    worm
    (Caenorhabditis elegans)    		 Secernentea rhi-13 rho GDP dissociation inhibitor 40(a)   X(4543798-4546035)   --
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT1G120701 Rho GDP-dissociation inhibitor-like protein 48.11(n)
    41.08(a)    		   837759  NM_101079.1  NP_172671.1 
    rice
    (Oryza sativa)    		 Liliopsida --
    --
    (see all 3)    		 rho GDP-dissociation inhibitor 1, putative, expres...
    rho GDP-dissociation inhibitor 1, putative, expres...
    (see all 3)    		 31(a)
    26(a)
    (see all 3)    		 many ↔ many
    many ↔ many
    (see all 3)    		 1(39820990-39822808)
    6(12321864-12325084)


    ENSEMBL Gene Tree for ARHGDIB (if available)
    TreeFam Gene Tree for ARHGDIB (if available) 

    Paralogs
    for ARHGDIB gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGDIB gene
    ARHGDIA2  ARHGDIG2  
    2 SIMAP similar genes for ARHGDIB using alignment to 5 protein entries:     GDIR2_HUMAN (see all proteins):
    ARHGDIG    ARHGDIA

    ARHGDIB for paralogs           About GeneDecksing



    Genomic Variants
    for ARHGDIB gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/448 NCBI SNPs in ARHGDIB are shown (see all 448)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1452537231,2
    		--15094452(+) GCAAT-/ATG   
       GATGA    AGCTG     		1 -- ds50010--------
    rs1405850451,2
    		--15094587(+) CACTGC/TGGACT 1 -- ds50010--------
    rs122981731,2
    		C,F,A,H,--15094621(+) GGGGCA/GTTTTT 1 -- ds500112Minor allele frequency- G:0.30NS EA NA CSA WA 786
    rs1838753601,2
    		--15094625(+) CATTTA/TTTGAA 1 -- ds50010--------
    rs71342901,2
    		C,F,A,--15094709(+) CTATAC/TCTAAT 1 -- ds50018Minor allele frequency- T:0.33NA CSA WA EA 368
    rs1448083461,2
    		--15094715(+) CTAATA/GTAAAA 1 -- ds50010--------
    rs1386614141,2
    		--15094724(+) AAGTCG/TAAATT 1 -- ds50010--------
    rs1889963341,2
    		--15094746(+) ACTAAA/GTAAGT 1 -- ds50010--------
    rs753574051,2
    		F,--15094848(+) CTCCTC/GCAGTG 1 -- ds50011Minor allele frequency- G:0.07WA 118
    rs73051671,2
    		C,F,H,--15094850(+) CCTCCA/GGTGTG 1 -- ds500111Minor allele frequency- G:0.04NS EA NA WA 1310

    HapMap Linkage Disequilibrium report for ARHGDIB (15094950 - 15114662 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for ARHGDIB: --

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    Disorders / Diseases
    for ARHGDIB gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    ARHGDIB for disorders           About GeneDecksing

    OMIM gene information: 602843    OMIM disorders: --

    14 diseases for ARHGDIB:    About MalaCards
    severe congenital neutropenia    urinary bladder cancer    neutropenia    hodgkin's lymphoma
    lung cancer    pulmonary disease    hematopoiesis    pancreatic carcinoma
    ovarian cancer    gastric cancer    breast cancer    pancreatitis
    carcinoma    prostatitis

    1 disease from the University of Copenhagen DISEASES database for ARHGDIB:
    Urinary bladder cancer

    1 Novoseek disease relationship for ARHGDIB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 2 15657050 (1), 18006811 (1)

    Human Genome Epidemiology (HuGE) Navigator: ARHGDIB (5 documents)

    Export disorders for ARHGDIB gene to outside databases

    Publications
    for ARHGDIB gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGDIB gene, integrated from 9 sources (see all 65):
    (articles sorted by number of sources associating them with ARHGDIB)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. (PubMed id 8434008)1, 2, 3, 9 Lelias J.M.... Lim B. (1993)
    2. Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. (PubMed id 8356058)1, 2, 3, 9 Scherle P.... Staudt L.M. (1993)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. (PubMed id 10655614)1, 2 Scheffzek K.... Gierschik P. (2000)
    6. Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton. (PubMed id 8262133)1, 2 Leffers H.... Celis J.E. (1993)
    7. Sequence analysis of proteins separated by polyacrylamide gel electrophoresis: towards an integrated protein database. (PubMed id 2226408)1, 2 Aebersold R. and Leavitt J. (1990)
    8. Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells. (PubMed id 18006811)1, 9 Schunke D....Dittmer J. (2007)
    9. Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways. (PubMed id 12386169)1, 9 Groysman M....Katzav S. (2002)
    10. Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation. (PubMed id 10664460)1, 9 Groysman M....Katzav S. (2000)

    External Searches for ARHGDIB gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing ARHGDIB gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 397 HGNC: 679 AceView: ARHGDIB Ensembl:ENSG00000111348 euGenes: HUgn397
    ECgene: ARHGDIB Kegg: 397 H-InvDB: ARHGDIB

    Other Databases showing ARHGDIB gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing ARHGDIB gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGDIB Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for ARHGDIB gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for ARHGDIB gene:
    Search GeneIP for patents involving ARHGDIB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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