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ARHGDIB Gene

protein-coding   GIFtS: 67
GCID: GC12M015094

Rho GDP Dissociation Inhibitor (GDI) Beta


(Previous symbols: RAP1GN1, GDIA2, GDID4)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GDP Dissociation Inhibitor (GDI) Beta1 2     Rho GDI 22 3
GDID41 2 3 5     D42 5
GDIA21 2 3     LYGDI2
RAP1GN11 2 3     RhoGDI22
Rho-GDI Beta2 3     Rho GDP-Dissociation Inhibitor 22
Ly-GDI2 3     

External Ids:    HGNC: 6791   Entrez Gene: 3972   Ensembl: ENSG000001113487   OMIM: 6028435   UniProtKB: P525663   

Export aliases for ARHGDIB gene to outside databases

Previous GC identifers: GC12M014834 GC12M015239 GC12M014995 GC12M014986 GC12M014864


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGDIB Gene:
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see
MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal
organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes
of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins
(GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including
ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 (PubMed
8356058)).(supplied by OMIM, Dec 2010)

GeneCards Summary for ARHGDIB Gene:
ARHGDIB (Rho GDP dissociation inhibitor (GDI) beta) is a protein-coding gene. GO annotations related to this gene include Rho GDP-dissociation inhibitor activity and GTPase activator activity. An important paralog of this gene is ARHGDIA.

UniProtKB/Swiss-Prot: GDIR2_HUMAN, P52566
Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from
them, and the subsequent binding of GTP to them

Gene Wiki entry for ARHGDIB Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_009714.18  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGDIB gene promoter:
         AML1a   Pbx1a   STAT5A   PPAR-gamma1   S8   Nkx6-1   HFH-1   ARP-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidARHGDIB promoter sequence
   Search Chromatin IP Primers for ARHGDIB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGDIB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p12.3   Ensembl cytogenetic band:  12p12.3   HGNC cytogenetic band: 12p12.3

ARHGDIB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGDIB gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M015094:  view genomic region     (about GC identifiers)

Start:
15,094,950 bp from pter      End:
15,114,662 bp from pter
Size:
19,713 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GDIR2_HUMAN, P52566 (See protein sequence)
Recommended Name: Rho GDP-dissociation inhibitor 2  
Size: 201 amino acids; 22988 Da
Subunit: Interacts with RHOA
1 PDB 3D structure from and Proteopedia for ARHGDIB:
1DS6 (3D)    
Secondary accessions: B5BU79

Explore the universe of human proteins at neXtProt for ARHGDIB: NX_P52566

Explore proteomics data for ARHGDIB at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys33, Lys50, Lys63, Lys102, Lys124, Lys138, Lys164, Lys175
  • Modification sites at PhosphoSitePlus

  • See ARHGDIB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001166.3  
    ENSEMBL proteins: 
     ENSP00000228945   ENSP00000445185   ENSP00000444860   ENSP00000440560   ENSP00000445263  
     ENSP00000437454   ENSP00000445450  
    Reactome Protein details: P52566

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    ProSpec Recombinant Protein for ARHGDIB
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    antibodies-online proteins for ARHGDIB (16 products) 

     
    antibodies-online peptides for ARHGDIB

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    antibodies-online kits for ARHGDIB (8 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR024792 RhoGDI_domain
     IPR000406 Rho_GDI

    Graphical View of Domain Structure for InterPro Entry P52566

    ProtoNet protein and cluster: P52566

    1 Blocks protein domain: IPB000406 RHO protein GDP dissociation inhibitor signature

    UniProtKB/Swiss-Prot: GDIR2_HUMAN, P52566
    Similarity: Belongs to the Rho GDI family


    Find genes that share domains with ARHGDIB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GDIR2_HUMAN, P52566
    Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from
    them, and the subsequent binding of GTP to them

         Genatlas biochemistry entry for ARHGDIB:
    Rho GDP-dissociation inhibitor (GDI) beta,aplysia related,preferentially expressed in hematopoietic cells (signal
    transduction)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005094Rho GDP-dissociation inhibitor activity IEA--
    GO:0005096GTPase activator activity IEA--
         
    Find genes that share ontologies with ARHGDIB           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for ARHGDIB:
     Increased cilium length after  

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Arhgdib):
     endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 
     reproductive system 

    Find genes that share phenotypes with ARHGDIB           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for ARHGDIB: Arhgdibtm1Len Arhgdibtm1Miyo

       genOway: Develop your customized and physiologically relevant rodent model for ARHGDIB

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    SwitchGear 3'UTR luciferase reporter plasmidARHGDIB 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GDIR2_HUMAN, P52566: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm TAS16130169
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169
    GO:0016023cytoplasmic membrane-bounded vesicle TAS9113980
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ARHGDIB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGDIB About   (see all 18)  
    See pathways by source

    SuperPathContained pathways About
    1Apoptosis and survival Caspase cascade
    FAS pathway and Stress induction of HSP regulation0.44
    Caspase cascade in apoptosis0.42
    2Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    3Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    4TWEAK Pathway
    Apoptosis through Death Receptors0.42
    Fas Signaling0.35
    5Apoptotic Pathways in Synovial Fibroblasts
    Actin-Based Motility by Rho Family GTPases0.62


    Find genes that share SuperPaths with ARHGDIB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGDIB (see all 10)
        Caspase Cascade
    RhoA Pathway
    Actin-Based Motility by Rho Family GTPases
    G12-G13 in Cellular Signaling
    Fas Signaling

    3 GeneGo (Thomson Reuters) Pathways for ARHGDIB
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway

    4 BioSystems Pathways for ARHGDIB
        G13 Signaling Pathway
    FAS pathway and Stress induction of HSP regulation
    Caspase cascade in apoptosis
    Regulation of RhoA activity


    1 Reactome Pathway for ARHGDIB
        Rho GTPase cycle


    2 Kegg Pathways  (Kegg details for ARHGDIB):
        Neurotrophin signaling pathway
    Vasopressin-regulated water reabsorption

        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARHGDIB: 
              Cytoskeleton Regulators in human mouse rat
              TNF Ligands & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARHGDIB

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGDIB (P525662, 3 ENSP000002289454) via UniProtKB, MINT, STRING, and/or I2D (see all 82)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RAC2P151532, 3, ENSP000002490714MINT-16596 MINT-24949 I2D: score=5 STRING: ENSP00000249071
    RAC1P630002, 3, ENSP000003484614MINT-8267885 I2D: score=4 STRING: ENSP00000348461
    RAC3P607632, 3, ENSP000003042834MINT-8267940 I2D: score=3 STRING: ENSP00000304283
    UFM1P619602, 3, ENSP000002398784MINT-8276883 I2D: score=2 STRING: ENSP00000239878
    RHOAP615863, ENSP000004001754I2D: score=3 STRING: ENSP00000400175
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS16130169
    GO:0006955immune response TAS8356058
    GO:0007162negative regulation of cell adhesion TAS9113980
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction TAS8356058

    Find genes that share ontologies with ARHGDIB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARHGDIB (GDIR2)

    2 HMDB Compounds for ARHGDIB    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    3 Novoseek inferred chemical compound relationships for ARHGDIB gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 78.1 5 7512369 (1), 15057873 (1), 8356058 (1), 18006811 (1) (see all 5)
    gtp 50.3 1 8356058 (1)
    tyrosine 10.5 2 10664460 (1), 12386169 (1)



    Find genes that share compounds with ARHGDIB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGDIB gene: 
    NM_001175.5  

    Unigene Cluster for ARHGDIB:

    Rho GDP dissociation inhibitor (GDI) beta
    Hs.504877  [show with all ESTs]
    Unigene Representative Sequence: AK125625
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000228945(uc001rcq.1) ENST00000536592 ENST00000541644 ENST00000539131
    ENST00000541546 ENST00000545895 ENST00000535676 ENST00000541380 ENST00000542276

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      QuantiFast Probe-based Assays in human, mouse, rat ARHGDIB

    Additional mRNA sequence: 

    AB451315.1 AB451445.1 AF498927.1 AK125625.1 AK311807.1 BC009200.2 L07916.1 L20688.1 
    X69549.1 

    Selected DOTS entries (see all 34):

    DT.100060471  DT.91847582  DT.91970763  DT.91793426  DT.92361848  DT.100678779  DT.100678784  DT.92380919 
    DT.75107035  DT.97765236  DT.100678782  DT.95271574  DT.121189599  DT.101967391  DT.91984917  DT.91769961 
    DT.100678780  DT.100871202  DT.80101095  DT.91769947  DT.95271572  DT.100049413  DT.121189624  DT.121189654 

    Selected AceView cDNA sequences (see all 1002):

    AA282251 AI589000 AA386037 AW576000 CR616298 BM509156 W94471 AA962516 
    AA838576 AA352805 BQ128224 BQ688932 BQ004620 AA354318 BU947641 AA875928 
    CR596151 BU730761 BX385934 AA477190 AA974384 BU146246 BM543327 H25930 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIB (see all 10)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
    SP1:                                -     -     -     -     -                       -           -                                       
    SP2:                                -     -     -     -     -                       -           -                                       
    SP3:                                -           -     -     -                       -           -                                       
    SP4:                                -     -     -     -     -                       -           -                                       
    SP5:                                -     -     -     -     -                       -           -                                       


    ECgene alternative splicing isoforms for ARHGDIB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    ARHGDIB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTGGCGCGAG
    ARHGDIB Expression
    About this image


    ARHGDIB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Endothelium (Cardiovascular System)
             Human umbilical vein endothelial cells (HUVEC)
     
     Bone (Muscoskeletal System)
             Bone Marrow
    ARHGDIB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGDIB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.504877
        Pathway & Disease-focused RT2 Profiler PCR Arrays including ARHGDIB: 
              Cytoskeleton Regulators in human mouse rat
              TNF Ligands & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGDIB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for ARHGDIB gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgdib1 , 5 Rho, GDP dissociation inhibitor (GDI) beta1, 5 83.5(n)1
    87(a)1
      6 (66.72 cM)5
    118571  NM_007486.41  NP_031512.11 
     1369235235 
    chicken
    (Gallus gallus)
    Aves ARHGDIB1 Rho GDP dissociation inhibitor (GDI) beta 81.5(n)
    90.5(a)
      417941  NM_001277364.1  NP_001264293.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGDIB6
    Rho GDP dissociation inhibitor (GDI) beta
    86(a)
    1 ↔ 1
    5(27794455-27803171)
    African clawed frog
    (Xenopus laevis)
    Amphibia arhgdib-prov2 Rho GDP dissociation inhibitor (GDI) beta 75.09(n)    BC056079.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc659662 similar to Rho GDP dissociation inhibitor (GDI) beta 75.02(n)   394132  BC056296.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGDI3 Rho GDP-dissociation inhibitor 50(a)   76D5   --
    worm
    (Caenorhabditis elegans)
    Secernentea rhi-13 rho GDP dissociation inhibitor 40(a)   X(4543798-4546035)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RDI16
    Rho GDP dissociation inhibitor involved in the loc...
    37(a)
    1 → many
    IV(218680-219288) YDL135C


    ENSEMBL Gene Tree for ARHGDIB (if available)
    TreeFam Gene Tree for ARHGDIB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGDIB gene
    ARHGDIA2  ARHGDIG2  
    2 SIMAP similar genes for ARHGDIB using alignment to 5 protein entries:     GDIR2_HUMAN (see all proteins):
    ARHGDIG    ARHGDIA

    Find genes that share paralogs with ARHGDIB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

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    Selected SNPs for ARHGDIB (see all 519)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1452537231,2
    C--15094452(+) GCAAT-/ATG   
       GATGA
    AGCTG
    1 -- ds50010--------
    rs1405850451,2
    C--15094587(+) CACTGC/TGGACT 1 -- ds50010--------
    rs122981731,2
    C,F,A,H--15094621(+) GGGGCA/GTTTTT 1 -- ds500112Minor allele frequency- G:0.30NS EA NA CSA WA 786
    rs1838753601,2
    --15094625(+) CATTTA/TTTGAA 1 -- ds50010--------
    rs71342901,2
    C,F,A--15094709(+) ctataC/Tctaat 1 -- ds50018Minor allele frequency- T:0.33NA CSA WA EA 368
    rs1448083461,2
    --15094715(+) CTAATA/GTAAAA 1 -- ds50010--------
    rs1386614141,2
    C--15094724(+) AAGTCG/TAAATT 1 -- ds50010--------
    rs1889963341,2
    --15094746(+) ACTAAA/GTAAGT 1 -- ds50010--------
    rs753574051,2
    F--15094848(+) CTCCTC/GCAGTG 1 -- ds50011Minor allele frequency- G:0.07WA 118
    rs73051671,2
    C,F,H--15094850(+) CCTCCA/GGTGTG 1 -- ds500111Minor allele frequency- G:0.04NS EA NA WA 1310

    HapMap Linkage Disequilibrium report for ARHGDIB (15094950 - 15114662 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for ARHGDIB:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv273504CNV Insertion20981092
    esv268382CNV Insertion20981092
    nsv469120CNV Gain19166990

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGDIB
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGDIB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602843    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for ARHGDIB:
    Urinary bladder cancer

    Find genes that share disorders with ARHGDIB           About GenesLikeMe

    1 Novoseek inferred disease relationship for ARHGDIB gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cancer 0 2 15657050 (1), 18006811 (1)

    Genetic Association Database (GAD): ARHGDIB
    Human Genome Epidemiology (HuGE) Navigator: ARHGDIB (5 documents)

    Export disorders for ARHGDIB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGDIB gene, integrated from 10 sources (see all 73):
    (articles sorted by number of sources associating them with ARHGDIB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. (PubMed id 8434008)1, 2, 3, 9 Lelias J.M.... Lim B. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. (PubMed id 8356058)1, 2, 3, 9 Scherle P.... Staudt L.M. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    6. Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway. (PubMed id 18676680)1, 4 Hosgood H.D....Lan Q. (Carcinogenesis 2008)
    7. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    8. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI. (PubMed id 10655614)1, 2 Scheffzek K.... Gierschik P. (Nat. Struct. Biol. 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 397 HGNC: 679 AceView: ARHGDIB Ensembl:ENSG00000111348 euGenes: HUgn397
    ECgene: ARHGDIB Kegg: 397 H-InvDB: ARHGDIB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for ARHGDIB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for ARHGDIB gene:
    Search GeneIP for patents involving ARHGDIB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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