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Aliases for ARHGDIB Gene

Aliases for ARHGDIB Gene

  • Rho GDP Dissociation Inhibitor Beta 2 3 5
  • Rho GDP Dissociation Inhibitor (GDI) Beta 2 3
  • Rho-GDI Beta 3 4
  • Rho GDI 2 3 4
  • RAP1GN1 3 4
  • Ly-GDI 3 4
  • GDIA2 3 4
  • GDID4 3 4
  • Rho GDP-Dissociation Inhibitor 2 3
  • RhoGDI2 3
  • LYGDI 3
  • D4 3

External Ids for ARHGDIB Gene

Previous HGNC Symbols for ARHGDIB Gene

  • RAP1GN1
  • GDIA2
  • GDID4

Previous GeneCards Identifiers for ARHGDIB Gene

  • GC12M014834
  • GC12M015239
  • GC12M014995
  • GC12M014986
  • GC12M015094
  • GC12M014864

Summaries for ARHGDIB Gene

Entrez Gene Summary for ARHGDIB Gene

  • Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

GeneCards Summary for ARHGDIB Gene

ARHGDIB (Rho GDP Dissociation Inhibitor Beta) is a Protein Coding gene. Among its related pathways are G-protein signaling_Regulation of CDC42 activity and DREAM Repression and Dynorphin Expression. GO annotations related to this gene include GTPase activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIG.

UniProtKB/Swiss-Prot for ARHGDIB Gene

  • Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).

Gene Wiki entry for ARHGDIB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGDIB Gene

Genomics for ARHGDIB Gene

Regulatory Elements for ARHGDIB Gene

Enhancers for ARHGDIB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F014945 1.4 FANTOM5 ENCODE 22.6 +6.4 6415 19.1 HDGF ATF1 PKNOX1 WRNIP1 SIN3A YBX1 YY1 ELK1 GATA2 ZNF143 ARHGDIB ERP27 PDE6H WBP11 ART4 H2AFJ HIST4H4 SMCO3 C12orf60 ENSG00000256339
GH12F014993 0.9 Ensembl ENCODE 13.4 -32.8 -32811 3.1 CTCF ZNF362 ZNF654 TRIM22 ZNF384 REST RAD21 YY1 JUND SMC3 ARHGDIB LOC105369670 LINC01489
GH12F014987 0.9 FANTOM5 Ensembl 12.9 -26.6 -26573 1.0 PKNOX1 MTA2 IKZF1 NBN MLLT1 TBX21 CREM SPI1 ARHGDIB LOC105369670 GC12P014973 GC12P014974
GH12F014927 0.9 Ensembl ENCODE 11 +32.8 32754 2.4 STAT1 ZHX2 DPF2 RAD21 ZNF217 CTBP1 JUND GATA3 RCOR1 ERP27 MGP C12orf60 ARHGDIB PDE6H ENSG00000256339 GC12M014903
GH12F014937 0.8 Ensembl ENCODE 11.4 +23.2 23249 2.7 CTCF MAFF SMC3 BCL6 MAFK RAD21 SPI1 ERP27 ARHGDIB PDE6H HIST4H4 ENSG00000256339 MGP C12orf60 GC12M014903
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARHGDIB on UCSC Golden Path with GeneCards custom track

Promoters for ARHGDIB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000426931 1228 4201 HDGF TBP PKNOX1 ATF1 WRNIP1 SIN3A BMI1 ZBTB40 YY1 GATA2

Genomic Location for ARHGDIB Gene

Chromosome:
12
Start:
14,942,015 bp from pter
End:
14,961,728 bp from pter
Size:
19,714 bases
Orientation:
Minus strand

Genomic View for ARHGDIB Gene

Genes around ARHGDIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGDIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGDIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGDIB Gene

Proteins for ARHGDIB Gene

  • Protein details for ARHGDIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52566-GDIR2_HUMAN
    Recommended name:
    Rho GDP-dissociation inhibitor 2
    Protein Accession:
    P52566
    Secondary Accessions:
    • B5BU79

    Protein attributes for ARHGDIB Gene

    Size:
    201 amino acids
    Molecular mass:
    22988 Da
    Quaternary structure:
    • Interacts with RHOA (PubMed:20400958). Interacts with RAC1 (PubMed:7512369). Interacts with RAC2 (PubMed:10655614). Interacts with CDC42 (PubMed:7512369).

    Three dimensional structures from OCA and Proteopedia for ARHGDIB Gene

neXtProt entry for ARHGDIB Gene

Post-translational modifications for ARHGDIB Gene

  • Ubiquitination at Lys 33, Lys 50, Lys 63, Lys 102, Lys 124, Lys 138, Lys 164, and Lys 175
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGDIB Gene

Domains & Families for ARHGDIB Gene

Protein Domains for ARHGDIB Gene

Suggested Antigen Peptide Sequences for ARHGDIB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52566

UniProtKB/Swiss-Prot:

GDIR2_HUMAN :
  • Belongs to the Rho GDI family.
Family:
  • Belongs to the Rho GDI family.
genes like me logo Genes that share domains with ARHGDIB: view

Function for ARHGDIB Gene

Molecular function for ARHGDIB Gene

GENATLAS Biochemistry:
Rho GDP-dissociation inhibitor (GDI) beta,aplysia related,preferentially expressed in hematopoietic cells (signal transduction)
UniProtKB/Swiss-Prot Function:
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them (PubMed:8356058, PubMed:7512369). Regulates reorganization of the actin cytoskeleton mediated by Rho family members (PubMed:8262133).

Gene Ontology (GO) - Molecular Function for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IMP 24554735
GO:0005094 Rho GDP-dissociation inhibitor activity IEA,IDA 7512369
GO:0005096 GTPase activator activity IEA --
GO:0005515 protein binding IPI 7512369
GO:0048365 Rac GTPase binding IDA 7512369
genes like me logo Genes that share ontologies with ARHGDIB: view
genes like me logo Genes that share phenotypes with ARHGDIB: view

Animal Models for ARHGDIB Gene

MGI Knock Outs for ARHGDIB:

Animal Model Products

miRNA for ARHGDIB Gene

miRTarBase miRNAs that target ARHGDIB

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGDIB Gene

Localization for ARHGDIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGDIB Gene

Cytoplasm, cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARHGDIB gene
Compartment Confidence
extracellular 5
cytoskeleton 5
cytosol 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS 16130169
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton TAS 16130169
GO:0016020 membrane IEA --
GO:0031410 cytoplasmic vesicle TAS 9113980
genes like me logo Genes that share ontologies with ARHGDIB: view

Pathways & Interactions for ARHGDIB Gene

genes like me logo Genes that share pathways with ARHGDIB: view

SIGNOR curated interactions for ARHGDIB Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 16130169
GO:0007162 negative regulation of cell adhesion TAS 9113980
GO:0007275 multicellular organism development TAS 8434008
GO:0035023 regulation of Rho protein signal transduction IMP 8262133
GO:0043547 positive regulation of GTPase activity IEA --
genes like me logo Genes that share ontologies with ARHGDIB: view

Drugs & Compounds for ARHGDIB Gene

(3) Drugs for ARHGDIB Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for ARHGDIB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARHGDIB: view

Transcripts for ARHGDIB Gene

Unigene Clusters for ARHGDIB Gene

Rho GDP dissociation inhibitor (GDI) beta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: -
SP8: -
SP9: - - - - - -
SP10: - - - - -

Relevant External Links for ARHGDIB Gene

GeneLoc Exon Structure for
ARHGDIB
ECgene alternative splicing isoforms for
ARHGDIB

Expression for ARHGDIB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for ARHGDIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGDIB Gene

This gene is overexpressed in Whole Blood (x27.8).

Protein differential expression in normal tissues from HIPED for ARHGDIB Gene

This gene is overexpressed in Lavage (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for ARHGDIB Gene



Protein tissue co-expression partners for ARHGDIB Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of ARHGDIB Gene:

ARHGDIB

SOURCE GeneReport for Unigene cluster for ARHGDIB Gene:

Hs.504877

mRNA Expression by UniProt/SwissProt for ARHGDIB Gene:

P52566-GDIR2_HUMAN
Tissue specificity: Detected in bone marrow, thymus and spleen.
genes like me logo Genes that share expression patterns with ARHGDIB: view

Primer Products

Orthologs for ARHGDIB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGDIB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGDIB 34 35
  • 99 (n)
dog
(Canis familiaris)
Mammalia ARHGDIB 34 35
  • 90.33 (n)
cow
(Bos Taurus)
Mammalia ARHGDIB 34 35
  • 89.17 (n)
oppossum
(Monodelphis domestica)
Mammalia ARHGDIB 35
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgdib 34
  • 83.67 (n)
mouse
(Mus musculus)
Mammalia Arhgdib 34 16 35
  • 83.5 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGDIB 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves ARHGDIB 34 35
  • 81.5 (n)
lizard
(Anolis carolinensis)
Reptilia ARHGDIB 35
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgdib 34
  • 73.67 (n)
Str.5653 34
African clawed frog
(Xenopus laevis)
Amphibia arhgdib-prov 34
zebrafish
(Danio rerio)
Actinopterygii arhgdig 34
  • 71.91 (n)
zgc65966 34
fruit fly
(Drosophila melanogaster)
Insecta RhoGDI 36 35
  • 50 (a)
worm
(Caenorhabditis elegans)
Secernentea rhi-1 36 35
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDI1 35
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToMany
Species where no ortholog for ARHGDIB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGDIB Gene

ENSEMBL:
Gene Tree for ARHGDIB (if available)
TreeFam:
Gene Tree for ARHGDIB (if available)

Paralogs for ARHGDIB Gene

Paralogs for ARHGDIB Gene

(2) SIMAP similar genes for ARHGDIB Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGDIB: view

Variants for ARHGDIB Gene

Sequence variations from dbSNP and Humsavar for ARHGDIB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10444404 -- 14,961,817(+) GCCTA(G/T)AGCTA upstream-variant-2KB
rs10492144 -- 14,961,037(-) TGTCA(A/C)ATATT intron-variant
rs10492145 -- 14,956,122(-) AAAGA(C/T)GACTG intron-variant
rs10492146 -- 14,953,088(-) TTACT(A/G)ATGAG intron-variant, upstream-variant-2KB
rs10492147 -- 14,952,769(-) GAACC(A/G)TTGTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for ARHGDIB Gene

Variant ID Type Subtype PubMed ID
nsv951333 CNV duplication 24416366
nsv557613 CNV gain 21841781
nsv469120 CNV gain 19166990
esv3580158 CNV loss 25503493
dgv1394n100 CNV gain 25217958

Variation tolerance for ARHGDIB Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGDIB Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
ARHGDIB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGDIB Gene

Disorders for ARHGDIB Gene

Relevant External Links for ARHGDIB

Genetic Association Database (GAD)
ARHGDIB
Human Genome Epidemiology (HuGE) Navigator
ARHGDIB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGDIB

No disorders were found for ARHGDIB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGDIB Gene

Publications for ARHGDIB Gene

  1. Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. (PMID: 8356058) Scherle P. … Staudt L.M. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 22 64
  2. cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. (PMID: 8434008) Lelias J.M. … Lim B. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 22 64
  3. Identification of a novel protein with GDP dissociation inhibitor activity for the ras-like proteins CDC42Hs and rac I. (PMID: 7512369) Adra C.N. … Lim B. (Genes Chromosomes Cancer 1993) 3 4 22 64
  4. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey L.T. … Malats N. (Eur. Urol. 2010) 3 46 64
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M. … Lan Q. (Environ. Mol. Mutagen. 2009) 3 46 64

Products for ARHGDIB Gene

Sources for ARHGDIB Gene

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