Aliases for ARHGDIB Gene
External Ids for ARHGDIB Gene
Previous Symbols for ARHGDIB Gene
Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]
GeneCards Summary for ARHGDIB Gene
ARHGDIB (Rho GDP Dissociation Inhibitor (GDI) Beta) is a Protein Coding gene. Among its related pathways are RhoGDI Pathway and Signaling by GPCR. GO annotations related to this gene include GTPase activator activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIG.
UniProtKB/Swiss-Prot for ARHGDIB Gene
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them