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Aliases for ARHGDIB Gene

Aliases for ARHGDIB Gene

  • Rho GDP Dissociation Inhibitor Beta 2 3
  • Rho GDP Dissociation Inhibitor (GDI) Beta 2 3 5
  • Rho-GDI Beta 3 4
  • Rho GDI 2 3 4
  • RAP1GN1 3 4
  • Ly-GDI 3 4
  • GDIA2 3 4
  • GDID4 3 4
  • RhoGDI2 3
  • LYGDI 3
  • D4 3

External Ids for ARHGDIB Gene

Previous HGNC Symbols for ARHGDIB Gene

  • RAP1GN1
  • GDIA2
  • GDID4

Previous GeneCards Identifiers for ARHGDIB Gene

  • GC12M014834
  • GC12M015239
  • GC12M014995
  • GC12M014986
  • GC12M015094
  • GC12M014864

Summaries for ARHGDIB Gene

Entrez Gene Summary for ARHGDIB Gene

  • Members of the Rho (or ARH) protein family (see MIM 165390) and other Ras-related small GTP-binding proteins (see MIM 179520) are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state. At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states: GTPase-activating proteins (GAPs), guanine nucleotide-releasing factors (GRFs), and GDP-dissociation inhibitors (GDIs). The GDIs, including ARHGDIB, decrease the rate of GDP dissociation from Ras-like GTPases (summary by Scherle et al., 1993 [PubMed 8356058]).[supplied by OMIM, Dec 2010]

GeneCards Summary for ARHGDIB Gene

ARHGDIB (Rho GDP Dissociation Inhibitor Beta) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by Rho GTPases. GO annotations related to this gene include GTPase activity and Rho GDP-dissociation inhibitor activity. An important paralog of this gene is ARHGDIG.

UniProtKB/Swiss-Prot for ARHGDIB Gene

  • Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Gene Wiki entry for ARHGDIB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARHGDIB Gene

Genomics for ARHGDIB Gene

Regulatory Elements for ARHGDIB Gene

Promoters for ARHGDIB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around ARHGDIB on UCSC Golden Path with GeneCards custom track

Genomic Location for ARHGDIB Gene

Chromosome:
12
Start:
14,942,015 bp from pter
End:
14,961,728 bp from pter
Size:
19,714 bases
Orientation:
Minus strand

Genomic View for ARHGDIB Gene

Genes around ARHGDIB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARHGDIB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARHGDIB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARHGDIB Gene

Proteins for ARHGDIB Gene

  • Protein details for ARHGDIB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P52566-GDIR2_HUMAN
    Recommended name:
    Rho GDP-dissociation inhibitor 2
    Protein Accession:
    P52566
    Secondary Accessions:
    • B5BU79

    Protein attributes for ARHGDIB Gene

    Size:
    201 amino acids
    Molecular mass:
    22988 Da
    Quaternary structure:
    • Interacts with RHOA.

    Three dimensional structures from OCA and Proteopedia for ARHGDIB Gene

neXtProt entry for ARHGDIB Gene

Proteomics data for ARHGDIB Gene at MOPED

Post-translational modifications for ARHGDIB Gene

  • Ubiquitination at Lys 33, Lys 50, Lys 63, Lys 102, Lys 124, Lys 138, Lys 164, and Lys 175
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for ARHGDIB Gene

Domains & Families for ARHGDIB Gene

Protein Domains for ARHGDIB Gene

Suggested Antigen Peptide Sequences for ARHGDIB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P52566

UniProtKB/Swiss-Prot:

GDIR2_HUMAN :
  • Belongs to the Rho GDI family.
Family:
  • Belongs to the Rho GDI family.
genes like me logo Genes that share domains with ARHGDIB: view

Function for ARHGDIB Gene

Molecular function for ARHGDIB Gene

GENATLAS Biochemistry:
Rho GDP-dissociation inhibitor (GDI) beta,aplysia related,preferentially expressed in hematopoietic cells (signal transduction)
UniProtKB/Swiss-Prot Function:
Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them.

Gene Ontology (GO) - Molecular Function for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IEA --
genes like me logo Genes that share ontologies with ARHGDIB: view
genes like me logo Genes that share phenotypes with ARHGDIB: view

Animal Models for ARHGDIB Gene

MGI Knock Outs for ARHGDIB:

Animal Model Products

CRISPR Products

miRNA for ARHGDIB Gene

miRTarBase miRNAs that target ARHGDIB

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for ARHGDIB Gene

Localization for ARHGDIB Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARHGDIB Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for ARHGDIB Gene COMPARTMENTS Subcellular localization image for ARHGDIB gene
Compartment Confidence
cytoskeleton 5
cytosol 5
extracellular 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,TAS 16130169
GO:0016023 cytoplasmic, membrane-bounded vesicle TAS 9113980
genes like me logo Genes that share ontologies with ARHGDIB: view

Pathways & Interactions for ARHGDIB Gene

genes like me logo Genes that share pathways with ARHGDIB: view

SIGNOR curated interactions for ARHGDIB Gene

Is inactivated by:
Other effect:

Gene Ontology (GO) - Biological Process for ARHGDIB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006928 movement of cell or subcellular component TAS 16130169
GO:0006955 immune response TAS --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007266 Rho protein signal transduction TAS --
GO:0007275 multicellular organism development TAS 8434008
genes like me logo Genes that share ontologies with ARHGDIB: view

Drugs & Compounds for ARHGDIB Gene

(3) Drugs for ARHGDIB Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for ARHGDIB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with ARHGDIB: view

Transcripts for ARHGDIB Gene

Unigene Clusters for ARHGDIB Gene

Rho GDP dissociation inhibitor (GDI) beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIB Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c · 11d · 11e
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - - - -
SP5: - - - - - - -
SP6: - - -
SP7: -
SP8: -
SP9: - - - - - -
SP10: - - - - -

Relevant External Links for ARHGDIB Gene

GeneLoc Exon Structure for
ARHGDIB
ECgene alternative splicing isoforms for
ARHGDIB

Expression for ARHGDIB Gene

mRNA expression in normal human tissues for ARHGDIB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for ARHGDIB Gene

This gene is overexpressed in Whole Blood (x27.8).

Protein differential expression in normal tissues from HIPED for ARHGDIB Gene

This gene is overexpressed in Lavage (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for ARHGDIB Gene



SOURCE GeneReport for Unigene cluster for ARHGDIB Gene Hs.504877

genes like me logo Genes that share expression patterns with ARHGDIB: view

Protein tissue co-expression partners for ARHGDIB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for ARHGDIB Gene

Orthologs for ARHGDIB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for ARHGDIB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia ARHGDIB 35
  • 99 (n)
  • 100 (a)
ARHGDIB 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia ARHGDIB 36
  • 93 (a)
OneToOne
ARHGDIB 35
  • 89.17 (n)
  • 93.5 (a)
dog
(Canis familiaris)
Mammalia ARHGDIB 35
  • 90.33 (n)
  • 94.5 (a)
ARHGDIB 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Arhgdib 36
  • 87 (a)
OneToOne
Arhgdib 16
Arhgdib 35
  • 83.5 (n)
  • 87 (a)
oppossum
(Monodelphis domestica)
Mammalia ARHGDIB 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia ARHGDIB 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Arhgdib 35
  • 83.67 (n)
  • 84.5 (a)
chicken
(Gallus gallus)
Aves ARHGDIB 36
  • 90 (a)
OneToOne
ARHGDIB 35
  • 81.5 (n)
  • 90.5 (a)
lizard
(Anolis carolinensis)
Reptilia ARHGDIB 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia arhgdib-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia arhgdib 35
  • 73.67 (n)
  • 77 (a)
Str.5653 35
zebrafish
(Danio rerio)
Actinopterygii arhgdig 35
  • 71.91 (n)
  • 77.53 (a)
zgc65966 35
fruit fly
(Drosophila melanogaster)
Insecta RhoGDI 37
  • 50 (a)
RhoGDI 36
  • 45 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea rhi-1 36
  • 40 (a)
OneToMany
rhi-1 37
  • 40 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RDI1 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for ARHGDIB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for ARHGDIB Gene

ENSEMBL:
Gene Tree for ARHGDIB (if available)
TreeFam:
Gene Tree for ARHGDIB (if available)

Paralogs for ARHGDIB Gene

Paralogs for ARHGDIB Gene

(2) SIMAP similar genes for ARHGDIB Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with ARHGDIB: view

Variants for ARHGDIB Gene

Sequence variations from dbSNP and Humsavar for ARHGDIB Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs918124 -- 14,956,637(+) TAATG(C/T)GGACC intron-variant, upstream-variant-2KB
rs1468890 -- 14,952,384(+) AACTC(A/T)GAAAA intron-variant
rs1861696 -- 14,959,982(+) CCAAT(A/G)GCAAG intron-variant
rs1861697 -- 14,960,000(+) ATGCC(G/T)GCTAG intron-variant
rs2430711 -- 14,950,671(+) TCATC(A/G)TCATC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for ARHGDIB Gene

Variant ID Type Subtype PubMed ID
nsv469120 CNV Gain 19166990
esv268382 CNV Insertion 20981092
esv273504 CNV Insertion 20981092

Variation tolerance for ARHGDIB Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.61; 13.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for ARHGDIB Gene

HapMap Linkage Disequilibrium report
ARHGDIB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for ARHGDIB Gene

Disorders for ARHGDIB Gene

Relevant External Links for ARHGDIB

Genetic Association Database (GAD)
ARHGDIB
Human Genome Epidemiology (HuGE) Navigator
ARHGDIB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
ARHGDIB

No disorders were found for ARHGDIB Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for ARHGDIB Gene

Publications for ARHGDIB Gene

  1. cDNA cloning of a human mRNA preferentially expressed in hematopoietic cells and with homology to a GDP-dissociation inhibitor for the rho GTP-binding proteins. (PMID: 8434008) Lelias J.M. … Lim B. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 4 23 67
  2. Ly-GDI, a GDP-dissociation inhibitor of the RhoA GTP-binding protein, is expressed preferentially in lymphocytes. (PMID: 8356058) Scherle P. … Staudt L.M. (Proc. Natl. Acad. Sci. U.S.A. 1993) 2 3 23
  3. Cyclooxygenase-2 is a target gene of rho GDP dissociation inhibitor beta in breast cancer cells. (PMID: 18006811) Schunke D. … Dittmer J. (Cancer Res. 2007) 3 23
  4. Vav1 and Ly-GDI two regulators of Rho GTPases, function cooperatively as signal transducers in T cell antigen receptor-induced pathways. (PMID: 12386169) Groysman M. … Katzav S. (J. Biol. Chem. 2002) 3 23
  5. Vav, a GDP/GTP nucleotide exchange factor, interacts with GDIs, proteins that inhibit GDP/GTP dissociation. (PMID: 10664460) Groysman M. … Katzav S. (FEBS Lett. 2000) 3 23

Products for ARHGDIB Gene

Sources for ARHGDIB Gene

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