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ARHGDIA Gene

protein-coding   GIFtS: 67
GCID: GC17M079825

Rho GDP Dissociation Inhibitor (GDI) Alpha


(Previous symbol: GDIA1)
  See ARHGDIA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Rho GDP Dissociation Inhibitor (GDI) Alpha1 2     HEL-S-47e2
GDIA11 2 3 5     RHOGDI2
Rho GDI 12 3     RHOGDI-12
Rho-GDI Alpha2 3     Epididymis Secretory Sperm Binding Protein Li 47e2
NPHS82 5     Rho GDP-Dissociation Inhibitor 12

External Ids:    HGNC: 6781   Entrez Gene: 3962   Ensembl: ENSG000001415227   OMIM: 6019255   UniProtKB: P525653   

Export aliases for ARHGDIA gene to outside databases

Previous GC identifers: GC17M079317 GC17M9I0128 GC17M080361 GC17M9I0504 GC17M9I7418 GC17M077419 GC17M075227


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for ARHGDIA Gene:
Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small
guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by
interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 (PubMed 8262133)).(supplied
by OMIM, Jan 2009)

GeneCards Summary for ARHGDIA Gene:
ARHGDIA (Rho GDP dissociation inhibitor (GDI) alpha) is a protein-coding gene. Diseases associated with ARHGDIA include familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis, and nephrotic syndrome, type 8. GO annotations related to this gene include Rho GDP-dissociation inhibitor activity and GTPase activator activity. An important paralog of this gene is ARHGDIG.

UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565
Function: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by
inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins
such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from
degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates
extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for
prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma
cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to
inactivation of RAC1

Gene Wiki entry for ARHGDIA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NC_018928.2  NT_010663.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the ARHGDIA gene promoter:
         AP-1   MyoD   CUTL1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARHGDIA promoter sequence
   Search Chromatin IP Primers for ARHGDIA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat ARHGDIA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

ARHGDIA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGDIA gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079825:  view genomic region     (about GC identifiers)

Start:
79,825,597 bp from pter      End:
79,829,282 bp from pter
Size:
3,686 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565 (See protein sequence)
Recommended Name: Rho GDP-dissociation inhibitor 1  
Size: 204 amino acids; 23207 Da
Subunit: Monomer. Interacts with FER. Interacts with PLXNB3 (By similarity). Forms a heterodimer with RAC1.
Interacts with RHOA, the affinity is increased by three orders of magnitude when RHOA is prenylated. Interacts
with PSMD10; the interaction increases ARHGDIA association with RHOA, leading to ARHGDIA-mediated inactivation of
RHOA and ROCK and prolonged AKT activation. Interacts with RHOC and CDC42
Selected PDB 3D structures from and Proteopedia for ARHGDIA (see all 19):
1CC0 (3D)        1FSO (3D)        1FST (3D)        1FT0 (3D)        1FT3 (3D)        1HH4 (3D)    
Secondary accessions: A8MXW0 B2R5X1 B4DDD3 B4DUV9 Q6IBM5
Alternative splicing: 2 isoforms:  P52565-1   P52565-2   

Explore the universe of human proteins at neXtProt for ARHGDIA: NX_P52565

Explore proteomics data for ARHGDIA at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys127, Lys141, Lys167
  • Modification sites at PhosphoSitePlus

  • See ARHGDIA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001172006.1  NP_001172007.1  NP_004300.1  

    ENSEMBL proteins: 
     ENSP00000269321   ENSP00000383556   ENSP00000463939   ENSP00000441348   ENSP00000464205  
     ENSP00000462960   ENSP00000461956   ENSP00000462209   ENSP00000463530   ENSP00000462323  
    Reactome Protein details: P52565

    ARHGDIA Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for ARHGDIA
    OriGene Protein Over-expression Lysate for ARHGDIA
    OriGene MassSpec for ARHGDIA
    OriGene Custom Protein Services for ARHGDIA
    GenScript Custom Purified and Recombinant Proteins Services for ARHGDIA
    Novus Biologicals ARHGDIA Proteins
    Novus Biologicals ARHGDIA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for ARHGDIA
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for ARHGDIA 

    ARHGDIA Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of ARHGDIA
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for ARHGDIA  (RhoGDI alpha)
    OriGene Antibodies for ARHGDIA
    OriGene Custom Antibody Services for ARHGDIA
    Novus Biologicals ARHGDIA Antibodies
    Abcam antibodies for ARHGDIA
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibody for ARHGDIA
    LSBio Antibodies in human, mouse, rat for ARHGDIA

    ARHGDIA Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for ARHGDIA
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for ARHGDIA
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for ARHGDIA 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR024792 RhoGDI_domain
     IPR000406 Rho_GDI

    Graphical View of Domain Structure for InterPro Entry P52565

    ProtoNet protein and cluster: P52565

    1 Blocks protein domain: IPB000406 RHO protein GDP dissociation inhibitor signature

    UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565
    Similarity: Belongs to the Rho GDI family


    Find genes that share domains with ARHGDIA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GDIR1_HUMAN, P52565
    Function: Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by
    inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins
    such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from
    degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates
    extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for
    prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma
    cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to
    inactivation of RAC1

         Genatlas biochemistry entry for ARHGDIA:
    Rho GDP-dissociation factor inhibitor (GDI) alpha,aplysia related

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005094Rho GDP-dissociation inhibitor activity IEA--
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI10489445
         
    Find genes that share ontologies with ARHGDIA           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGDIA:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 

         9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgdia):
     behavior/neurological  cardiovascular system  endocrine/exocrine gland  hematopoietic system  homeostasis/metabolism 
     immune system  mortality/aging  renal/urinary system  reproductive system 

    Find genes that share phenotypes with ARHGDIA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Arhgdiatm1Ytk for ARHGDIA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for ARHGDIA
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for ARHGDIA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGDIA
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGDIA

    miRNA
    Products:
        
    miRTarBase miRNAs that target ARHGDIA:
    hsa-mir-92a-3p (MIRT049570), hsa-mir-877-3p (MIRT036932), hsa-mir-151a-5p (MIRT004486), hsa-mir-423-5p (MIRT038106), hsa-mir-183-5p (MIRT047092), hsa-mir-16-5p (MIRT001479), hsa-mir-484 (MIRT042136), hsa-mir-744-5p (MIRT037531)

    Block miRNA regulation of human, mouse, rat ARHGDIA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGDIA (see all 29):
    hsa-miR-3910 hsa-miR-429 hsa-miR-15a hsa-miR-1271 hsa-miR-486-3p hsa-miR-650 hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidARHGDIA 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for ARHGDIA
    Predesigned siRNA for gene silencing in human, mouse, rat ARHGDIA

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for ARHGDIA

    Clone
    Products:
         
    OriGene clones in human, mouse for ARHGDIA (see all 9)
    OriGene ORF clones in mouse, rat for ARHGDIA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ARHGDIA (NM_004309)
    Sino Biological Human cDNA Clone for ARHGDIA
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGDIA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGDIA

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for ARHGDIA
    Browse ESI BIO Cell Lines and PureStem Progenitors for ARHGDIA 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGDIA


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GDIR1_HUMAN, P52565: Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol4
    nucleus2
    plasma membrane2
    extracellular1
    vacuole1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with ARHGDIA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for ARHGDIA About   (see all 24)  
    See pathways by source

    SuperPathContained pathways About
    1p75 NTR receptor-mediated signalling
    p75 NTR receptor-mediated signalling0.74
    Axonal growth inhibition (RHOA activation)0.00
    p75NTR regulates axonogenesis0.00
    Axonal growth stimulation0.00
    2Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    3Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    4CDC42 signaling events
    CDC42 signaling events0.34
    RAC1 signaling pathway0.34
    5Signaling by FGFR
    Signalling by NGF0.71


    Find genes that share SuperPaths with ARHGDIA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for ARHGDIA (see all 6)
        RhoA Pathway
    Actin-Based Motility by Rho Family GTPases
    RhoGDI Pathway
    Rho Family GTPases
    Actin Nucleation by ARP-WASP Complex

    1 Cell Signaling Technology (CST) Pathway for ARHGDIA
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for ARHGDIA (see all 7)
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Rac2 regulation pathway
    G-protein signaling RhoB regulation pathway
    G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway

    Selected BioSystems Pathways for ARHGDIA (see all 6)
        p75(NTR)-mediated signaling
    CDC42 signaling events
    Regulation of CDC42 activity
    Regulation of RhoA activity
    Regulation of RAC1 activity


    3 Reactome Pathways for ARHGDIA
        Axonal growth inhibition (RHOA activation)
    Axonal growth stimulation
    Rho GTPase cycle


    2 Kegg Pathways  (Kegg details for ARHGDIA):
        Neurotrophin signaling pathway
    Vasopressin-regulated water reabsorption

        Pathway & Disease-focused RT2 Profiler PCR Array including ARHGDIA: 
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for ARHGDIA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for ARHGDIA (P525651, 2, 3 ENSP000002693214) via UniProtKB, MINT, STRING, and/or I2D (see all 200)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RDXP352412, 3, ENSP000003428304MINT-18849 MINT-18848 I2D: score=4 STRING: ENSP00000342830
    CDKN1BP465272, 3, ENSP000002288724MINT-63858 I2D: score=5 STRING: ENSP00000228872
    FEN1P397482, 3, ENSP000003054804MINT-63857 I2D: score=5 STRING: ENSP00000305480
    JUPP149232, 3, ENSP000003111134MINT-63856 I2D: score=5 STRING: ENSP00000311113
    RAC3P607632, 3, ENSP000003042834MINT-8267929 I2D: score=3 STRING: ENSP00000304283
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS16130169
    GO:0007162negative regulation of cell adhesion TAS8262133
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction IEA--
    GO:0032880regulation of protein localization IEA--

    Find genes that share ontologies with ARHGDIA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for ARHGDIA (GDIR1)

    2 HMDB Compounds for ARHGDIA    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for ARHGDIA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 68.8 3 11285260 (2), 10716190 (1)
    gtp 63.8 4 10716190 (4)



    Find genes that share compounds with ARHGDIA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for ARHGDIA gene (3 alternative transcripts): 
    NM_001185077.1  NM_001185078.1  NM_004309.4  

    Unigene Cluster for ARHGDIA:

    Rho GDP dissociation inhibitor (GDI) alpha
    Hs.159161  [show with all ESTs]
    Unigene Representative Sequence: NM_001185077
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000582520 ENST00000269321(uc021uff.1 uc002kbq.3 uc021ufg.1 uc010dig.2)
    ENST00000400721 ENST00000584461 ENST00000541078 ENST00000580685 ENST00000579121
    ENST00000581876 ENST00000583868 ENST00000582984 ENST00000580033 ENST00000583791
    ENST00000578351 ENST00000583111 ENST00000584397 ENST00000583499 ENST00000582309

    miRNA
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    Block miRNA regulation of human, mouse, rat ARHGDIA using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate ARHGDIA (see all 29):
    hsa-miR-3910 hsa-miR-429 hsa-miR-15a hsa-miR-1271 hsa-miR-486-3p hsa-miR-650 hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidARHGDIA 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat ARHGDIA
    Clone
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    OriGene clones in human, mouse for ARHGDIA (see all 9)
    OriGene ORF clones in mouse, rat for ARHGDIA
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): ARHGDIA (NM_004309)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for ARHGDIA
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGDIA
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for ARHGDIA
    OriGene qSTAR qPCR primer pairs in human, mouse for ARHGDIA
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat ARHGDIA
      QuantiTect SYBR Green Assays in human, mouse, rat ARHGDIA
      QuantiFast Probe-based Assays in human, mouse, rat ARHGDIA

    Additional mRNA sequence: 

    AF498926.1 AK293147.1 AK300816.1 AK312347.1 BC005851.2 BC005875.2 BC007630.1 BC008701.3 
    BC009759.2 BC013846.1 BC016031.1 BC016185.1 BC024258.1 BC027730.2 BC028333.1 BC075827.1 
    BC106044.1 BT006884.1 CR456777.1 D13989.1 M97579.1 X69550.1 

    Selected DOTS entries (see all 53):

    DT.97856243  DT.91684644  DT.92471322  DT.100695007  DT.100767630  DT.97856170  DT.100694962  DT.95337225 
    DT.120995517  DT.95110686  DT.100039713  DT.100039717  DT.100039702  DT.120995317  DT.100694992  DT.100694978 
    DT.100694994  DT.100637405  DT.100637925  DT.100694986  DT.120995363  DT.100637549  DT.100694993  DT.100695003 

    Selected AceView cDNA sequences (see all 367):

    AI368502 AA578542 F07681 AI936667 BM466416 AA378122 BM819949 BQ437686 
    AI090279 AW575184 BX333198 AI687437 BG256930 BU624345 BU601823 CB528621 
    BF854551 BQ026779 T28915 BM832744 AL554477 BU196600 BU734484 BQ708585 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIA (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h ^ 8a · 8b ^ 9
    SP1:                          -                                         -           -                                                                     
    SP2:                                                                    -           -                                                                     
    SP3:                                                                    -           -                       -     -     -     -     -     -               
    SP4:                          -           -     -     -                 -           -                                                                     
    SP5:                          -                                         -           -                                                                     


    ECgene alternative splicing isoforms for ARHGDIA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    ARHGDIA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCTCCCC
    ARHGDIA Expression
    About this image


    ARHGDIA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 21) fully expand
     
     Thymus (Hematopoietic System)
             Double Negative 2 Thymocytes Thymus
     
     Blood (Cardiovascular System)
             Double Negative 2 Thymocytes Thymus
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Heart (Cardiovascular System)
             Outflow Tract
    ARHGDIA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    ARHGDIA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.159161
        Pathway & Disease-focused RT2 Profiler PCR Array including ARHGDIA: 
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARHGDIA gene from Selected species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgdia1 , 5 Rho GDP dissociation inhibitor (GDI) alpha1, 5 88.4(n)1
    97.06(a)1
      11 (84.29 cM)5
    1926621  NM_133796.71  NP_598557.31 
     1205781045 
    chicken
    (Gallus gallus)
    Aves ARHGDIA1 Rho GDP dissociation inhibitor (GDI) alpha 83.5(n)
    91.18(a)
      769231  NM_001080871.1  NP_001074340.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGDIA6
    Rho GDP dissociation inhibitor (GDI) alpha
    87(a)
    1 ↔ 1
    2(118584879-118588892)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.139782 Xenopus laevis transcribed sequence with moderate similarity more 74.34(n)    CA791691.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa96g112 Danio rerio cDNA clone MGC55554 IMAGE2642774, complete more 80.15(n)    BC063968.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGDI1 , 3 Rho GDP-dissociation inhibitor3
    RhoGDI1
    52(a)3
    59.42(n)1
    54.35(a)1
      76D53
    401791  NM_001275151.11  NP_001262080.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rhi-11 , 3 rho GDP dissociation inhibitor3
    rhi-11
    39(a)3
    50.09(n)1
    40.33(a)1
      X(4543798-4546035)3
    1807211  NM_076373.51  NP_508774.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RDI1(YDL135C)4
    RDI11
    Rho GDP dissociation inhibitor involved in the localization more4
    RDI11
    45.95(n)1
    41.81(a)1
      4(219288-218680)4
    8514201, 4  NP_010146.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SCN11 SCN1 49.41(n)
    40.61(a)
      819979  NM_111667.3  NP_187445.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g03183001 Os06g0318300 54.64(n)
    40.98(a)
      4340881  NM_001064037.1  NP_001057502.1 


    ENSEMBL Gene Tree for ARHGDIA (if available)
    TreeFam Gene Tree for ARHGDIA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for ARHGDIA gene
    ARHGDIG2  ARHGDIB2  
    2 SIMAP similar genes for ARHGDIA using alignment to 6 protein entries:     GDIR1_HUMAN (see all proteins):
    ARHGDIG    ARHGDIB

    Find genes that share paralogs with ARHGDIA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for ARHGDIA (see all 187)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378699621,2
    --79825197(+) TTGGGA/GTCCAG 3 -- int10--------
    rs1424754851,2
    --79825244(+) CACCTC/TCAAGC 3 -- int10--------
    rs1908623011,2
    --79825296(+) CTACAC/TAAGCC 3 -- int10--------
    rs1459583391,2
    C--79825308(+) GGCCCA/GTCTTC 3 -- int10--------
    rs1134079531,2
    C,F--79825332(+) AAGGAG/CGGGCA 3 -- int11Minor allele frequency- C:0.50NA 2
    rs1419700461,2
    --79825578(+) AGCCAA/CGCAGC 3 -- int10--------
    rs1506639341,2
    --79825585(+) CAGCAA/GACACC 3 -- int10--------
    rs1837152871,2
    --79825631(+) AAAAGA/CAGCAG 3 -- ut310--------
    rs1881919541,2
    --79825729(+) GTGTGC/TACTTG 3 -- ut310--------
    rs1929566741,2
    --79825743(+) CCTTGG/TTTGTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ARHGDIA (79825597 - 79829282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for ARHGDIA (see all 16):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909134CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv833569CNV Loss17160897
    dgv3340n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3338n71CNV Loss21882294
    dgv3337n71CNV Loss21882294
    dgv3339n71CNV Loss21882294
    dgv3330n71CNV Loss21882294

    Human Gene Mutation Database (HGMD): ARHGDIA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing ARHGDIA
    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGDIA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601925   
    OMIM disorders: 615244  
    UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565
  • Nephrotic syndrome 8 (NPHS8) [MIM:615244]: A form of nephrotic syndrome, a renal disease clinically
    characterized by progressive renal failure, severe proteinuria, hypoalbuminemia, hyperlipidemia and edema. Kidney
    biopsies show diffuse mesangial sclerosis, with small glomeruli, hypercellularity, increased extracellular
    matrix, and contracted/collapsed glomerular tufts surrounded by immature or abnormal podocytes. Note=The disease
    is caused by mutations affecting the gene represented in this entry

  • 3 diseases for ARHGDIA:    
    About MalaCards
    familial idiopathic steroid-resistant nephrotic syndrome with diffuse mesangial sclerosis    nephrotic syndrome, type 8    nephrotic syndrome


    Find genes that share disorders with ARHGDIA           About GenesLikeMe


    Export disorders for ARHGDIA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for ARHGDIA gene, integrated from 10 sources (see all 114):
    (articles sorted by number of sources associating them with ARHGDIA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ARHGDIA: a novel gene implicated in nephrotic syndrome. (PubMed id 23434736)1, 2 Gupta I.R....Takano T. (J. Med. Genet. 2013)
    2. Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1. (PubMed id 20400958)1, 2 Boulter E....Burridge K. (Nat. Cell Biol. 2010)
    3. Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells. (PubMed id 20628200)1, 2 Man J.H....Zhang X.M. (J. Clin. Invest. 2010)
    4. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1, 2 Kim S.C.... Zhao Y. (Mol. Cell 2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3. (PubMed id 9186513)1, 3 Wagner T....Scherer G. (Cytogenet. Cell Genet. 1997)
    7. A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. (PubMed id 9195882)1, 2 Keep N.H.... Roberts G.C.K. (Structure 1997)
    8. Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton. (PubMed id 8262133)1, 2 Leffers H.... Celis J.E. (Exp. Cell Res. 1993)
    9. Overexpression of RhoGDI, a novel predictor of distant metastasis, promotes cell proliferation and migration in hepatocellular carcinoma. (PubMed id 24374343)1 Wang H....Zhao L. (FEBS Lett. 2013)
    10. Downregulation of RhoGDII+ increased migration and invasion of ER (+) MCF7 and ER (-) MDA-MB-231 breast cancer cells. (PubMed id 23563506)1 Hooshmand S....Mojtahedi Z. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 396 HGNC: 678 AceView: ARHGDIA.1 Ensembl:ENSG00000141522 euGenes: HUgn396
    ECgene: ARHGDIA Kegg: 396 H-InvDB: ARHGDIA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for ARHGDIA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for ARHGDIA gene:
    Search GeneIP for patents involving ARHGDIA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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