ARHGDIA Gene
protein-coding GIFtS: 65
GCID: GC17M079825
|
|
Rho GDP dissociation inhibitor (GDI) alpha
(Previous symbol: GDIA1)
| |
Aliases
for ARHGDIA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Rho GDP Dissociation Inhibitor (GDI) Alpha1 2 | | Rho-GDI Alpha2 3 | | GDIA11 2 3 | | RHOGDI-12 | | RHOGDI1 2 | | Rho GDP-Dissociation Inhibitor 12 | | Rho GDI 12 3 | | |
Export aliases for ARHGDIA gene to outside databasesPrevious GC identifers: GC17M079317 GC17M9I0128 GC17M080361 GC17M9I0504 GC17M9I7418 GC17M077419 GC17M075227 |
Summaries
for ARHGDIA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for ARHGDIA:
Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guaninenucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interactionwith GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 (PubMed 8262133)).(supplied by OMIM, Jan 2009)
UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them,and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating thesignals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity)
Gene Wiki entry for ARHGDIA
|
Genomic Views
for ARHGDIA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010663.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the ARHGDIA gene promoter:
AP-1 MyoD CUTL1 C/EBPalpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for ARHGDIA
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGDIA |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.3 Ensembl cytogenetic band: 17q25.3 HGNC cytogenetic band: 17q25.3ARHGDIA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M079825: view genomic region
(about GC identifiers)
Start:
|
79,825,597 bp from pter |
End:
|
79,829,282 bp from pter |
Size:
|
3,686 bases |
Orientation:
|
minus strand |
|
Proteins
for ARHGDIA gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565 (See
protein sequence)Recommended Name: Rho GDP-dissociation inhibitor 1 Size: 204 amino acids; 23207 Da
Subunit: Monomer. Forms a heterodimer with RAC1. Interacts with PLXNB3 (By similarity). Interacts with FER. Interactswith PSMD10 and RHOA; the interaction with PSMD10 increases ARHGDIA association with RHOA, leading to ARHGDIA-mediatedinactivation of RHOA and ROCK and prolonged AKT activation
Subcellular location: Cytoplasm
6/19 PDB 3D structures from  and Proteopedia  for ARHGDIA (see all 19):1CC0 (3D)
1FSO (3D)
1FST (3D)
1FT0 (3D)
1FT3 (3D)
1HH4 (3D)
Secondary accessions: B2R5X1 Q6IBM5Explore the universe of human proteins at neXtProt for ARHGDIA: NX_P52565
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P52565
ARHGDIA Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001172006.1 NP_001172007.1 NP_004300.1
ENSEMBL proteins: ENSP00000269321 ENSP00000383556 ENSP00000463939 ENSP00000441348 ENSP00000464205 ENSP00000462960 ENSP00000461956 ENSP00000462209 ENSP00000463530 ENSP00000462323 Reactome Protein details: P52565
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
ARHGDIA for ontologies About GeneDecksing
ARHGDIA Antibody Products:
Assay Products for ARHGDIA: |
Protein
Domains /
Families
for ARHGDIA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
ARHGDIA for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P52565ProtoNet protein and cluster: P52565 1 Blocks protein family: IPB000406 RHO protein GDP dissociation inhibitor signature
UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565Similarity: Belongs to the Rho GDI family |
Function
for ARHGDIA gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them,and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by mediating thesignals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity) Genatlas biochemistry entry for ARHGDIA:Rho GDP-dissociation factor inhibitor (GDI) alpha,aplysia related
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGDIA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGDIA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): ARHGDIA (NM_004309) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGDIA | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGDIA |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGDIA |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005094 | Rho GDP-dissociation inhibitor activity |
IEA | -- | | GO:0005096 | GTPase activator activity |
IEA | -- | | GO:0005515 | protein binding |
IPI | -- |
ARHGDIA for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for ARHGDIA:
Animal Models:
Mouse knock-out Arhgdiatm1Ytk for ARHGDIA
10 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Arhgdia):
ARHGDIA for phenotypes About GeneDecksing
|
Pathways & Interactions
for ARHGDIA gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/22 super-pathways (see all 22) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | G-protein signaling Regulation of RAC1 activity | | | 2 | G-protein signaling_RhoA regulation pathway | | | 3 | Cell death signalling via NRAGE, NRIF and NADE | | | 4 | Axonal growth inhibition (RHOA activation) | | | 5 | Development MAG-dependent inhibition of neurite outgrowth | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5/7 EMD Millipore Pathways for ARHGDIA (see all 7)
5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGDIA (see all 6)
1 
Cell Signaling Technology (CST) Pathway for ARHGDIA
5/7  GeneGo (Thomson Reuters) Pathways for ARHGDIA (see all 7)
5/6  BioSystems Pathways for ARHGDIA (see all 6)
5/8 
Reactome Pathways for ARHGDIA (see all 8)
2 
Kegg Pathways (Kegg details for ARHGDIA):
ARHGDIA for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGDIA
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/159 Interacting proteins for ARHGDIA (P525651, 2, 3 ENSP000002693214) via UniProtKB, MINT, STRING, and/or I2D (see all 159)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| RDX | P352412, 3, ENSP000003428304 | MINT-18849 MINT-18848 I2D:
score=4 STRING: ENSP00000342830 | | CDKN1B | P465272, 3, ENSP000002288724 | MINT-63858 I2D:
score=5 STRING: ENSP00000228872 | | FEN1 | P397482, 3, ENSP000003054804 | MINT-63857 I2D:
score=5 STRING: ENSP00000305480 | | JUP | P149232, 3, ENSP000003111134 | MINT-63856 I2D:
score=5 STRING: ENSP00000311113 | | RAC3 | P607632, 3, ENSP000003042834 | MINT-8267929 I2D:
score=3 STRING: ENSP00000304283 |
About this table
Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11): About this table
ARHGDIA for ontologies About GeneDecksing
|
Drugs & Compounds
for ARHGDIA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
ARHGDIA for compounds About GeneDecksing
 Browse Tocris compounds for ARHGDIA
2 HMDB Compounds for ARHGDIA About this table
2 Novoseek chemical compound relationships for ARHGDIA gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| gdp |
68.8 |
3 |
11285260 (2), 10716190 (1) |
| gtp |
63.8 |
4 |
10716190 (4) |
Search CenterWatch for drugs/clinical trials and news about ARHGDIA / GDIR1
|
Transcripts
for ARHGDIA gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for ARHGDIA gene (3 alternative transcripts): NM_001185077.1 NM_001185078.1 NM_004309.4 Unigene Cluster for ARHGDIA: Rho GDP dissociation inhibitor (GDI) alpha Hs.159161 [show with all ESTs]Unigene Representative Sequence: NM_00118507717 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000582520 ENST00000269321(uc021uff.1 uc002kbq.3 uc021ufg.1 uc010dig.2)
ENST00000400721 ENST00000584461 ENST00000541078 ENST00000580685 ENST00000579121
ENST00000581876 ENST00000583868 ENST00000582984 ENST00000580033 ENST00000583791
ENST00000578351 ENST00000583111 ENST00000584397 ENST00000583499 ENST00000582309
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGDIA (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGDIA
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): ARHGDIA (NM_004309) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for ARHGDIA | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGDIA |
Additional cDNA sequence: AF498926.1 AK293147.1 AK300816.1 AK312347.1 BC005851.2 BC005875.2 BC007630.1 BC008701.3 BC009759.2 BC013846.1 BC016031.1 BC016185.1 BC024258.1 BC027730.2 BC028333.1 BC075827.1 BC106044.1 BT006884.1 CR456777.1 D13989.1 M97579.1 X69550.1 24/53 DOTS entries (see all 53): DT.97856243 DT.91684644 DT.92471322 DT.100695007 DT.100767630 DT.97856170 DT.100694962 DT.95337225 DT.120995517 DT.95110686 DT.100039713 DT.100039717 DT.100039702 DT.100694992 DT.120995317 DT.100694978 DT.100694994 DT.100637405 DT.100637925 DT.100694986 DT.101985618 DT.120995363 DT.100637549 DT.100649454 24/367 AceView cDNA sequences (see all 367): AA378122 F07681 AI936667 AA578542 BM466416 AI368502 BM550876 CA425601 AI584101 CB139605 CF455678 BG912823 CR456777 BQ045215 BQ054339 BQ708585 BG420784 AW575184 BX333198 BG032480 BQ955538 AL554477 BF854551 BM549838
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIA (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | · | 7f | · | 7g | · | 7h | ^ | 8a | · | 8b | ^ | 9 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | |
| SP4: | | | | | | | | | - | | | | - | | - | | - | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for ARHGDIA
|
Expression
for ARHGDIA gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| ARHGDIA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGCCTCCCC
About this image
See ARHGDIA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for ARHGDIA
SOURCE GeneReport for Unigene cluster: Hs.159161
SABiosciences Expression via Pathway-Focused PCR Array including ARHGDIA:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGDIA
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat ARHGDIA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGDIA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGDIA | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGDIA |
Orthologs
for ARHGDIA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for ARHGDIA gene from 9/31 species (see all 31) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
ARHGDIA1 |
Rho GDP dissociation inhibitor (GDI) alpha |
83.5(n)
91.18(a) |
|
769231 NM_001080871.1 NP_001074340.1 |
lizard
(Anolis carolinensis) |
Reptilia |
ARHGDIA6 |
-- |
87(a) |
1 ↔ 1 |
2(118584879-118588802) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.139782 |
Xenopus laevis transcribed sequence with moderate similarity more |
74.34(n) |
|
CA791691.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
wufa96g112 |
Danio rerio cDNA clone MGC55554 IMAGE2642774, complete more |
80.15(n) |
|
BC063968.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
RhoGDI1 , 3 |
Rho GDP-dissociation inhibitor3
CG7823-PA1 |
52(a)3
57.48(n)1
51.89(a)1 |
|
76D53
401791 NM_140905.21 NP_649162.11 |
worm
(Caenorhabditis elegans) |
Secernentea |
rhi-11 , 3 |
rho GDP dissociation inhibitor3
Protein RHI-11 |
39(a)3
50.09(n)1
40.33(a)1 |
|
X(4543798-4546035)3
1807211 NM_076373.41 NP_508774.11 |
baker's yeast
(Saccharomyces cerevisiae) |
Saccharomycetes |
RDI1(YDL135C)4
RDI11 |
Rho GDP dissociation inhibitor involved in the localization more4
Rdi1p1 |
45.51(n)1
41.01(a)1 |
|
4(219288-218680)4
8514201, 4 NP_010146.11, 4 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
SCN11 |
Rho GDP-dissociation inhibitor 1 |
48.48(n)
39.39(a) |
|
819979 NM_111667.3 NP_187445.1 |
rice
(Oryza sativa) |
Liliopsida |
Os06g03183001 |
hypothetical protein |
53.87(n)
39.9(a) |
|
4340881 NM_001064037.1 NP_001057502.1 |
ENSEMBL Gene Tree for ARHGDIA (if available)
TreeFam Gene Tree for ARHGDIA (if available) |
Paralogs
for ARHGDIA gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for ARHGDIA gene
- ARHGDIG2 ARHGDIB2
2 SIMAP similar genes for ARHGDIA using alignment to 7 protein entries: GDIR1_HUMAN (see all proteins):ARHGDIG ARHGDIB
ARHGDIA for paralogs About GeneDecksing
|
Genomic Variants
for ARHGDIA gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for ARHGDIA (79825597 - 79829282 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for ARHGDIA
3 CNVs: 30036 73078 5041 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGDIA |
|
Disorders
/ Diseases
for ARHGDIA gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
ARHGDIA for disorders About GeneDecksing
OMIM gene information: 601925
OMIM disorders: --
8  diseases for ARHGDIA: About MalaCardsinflammatory bowel disease oligodendroglioma hematopoiesis colon cancer
colorectal cancer breast cancer schizophrenia carcinoma
Export disorders for ARHGDIA gene to outside databases
|
Publications
for ARHGDIA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for ARHGDIA gene, integrated from 9 sources (see all 98):
(articles sorted by number of sources associating them with ARHGDIA) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Gankyrin plays an essential role in Ras-induced tumor igenesis through regulation of the RhoA/ROCK pathway in mammalian cells. (PubMed id 20628200)1, 2 Man J.H....Zhang X.M. (2010)
- Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1, 2 Kim S.C.... Zhao Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3. (PubMed id 9186513)1, 3 Wagner T....Scherer G. (1997)
- A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. (PubMed id 9195882)1, 2 Keep N.H.... Roberts G.C.K. (1997)
- Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton. (PubMed id 8262133)1, 2 Leffers H.... Celis J.E. (1993)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Knockdown of RhoGDIa induces apoptosis and increases l ung cancer cell chemosensitivity to paclitaxel. (PubMed id 22668020)1 Rong F....Tao M. (2012)
- Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)
- Rho GDP-dissociation inhibitor alpha is associated wit h cancer metastasis in colon and prostate cancer. (PubMed id 22530308)1 Yamashita T....Tsunoda S. (2012)
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External Searches for ARHGDIA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing ARHGDIA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
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Other Databases showing ARHGDIA gene
(According to HUGE)
About This Section
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Specialized Databases showing ARHGDIA gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| Name | Description |
| PharmGKB entry for ARHGDIA | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for ARHGDIA gene:
Search GeneIP for patents involving ARHGDIA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for ARHGDIA gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | OriGene Antibodies for ARHGDIA | | OriGene shRNA RFP for ARHGDIA | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for ARHGDIA | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for ARHGDIA | | | OriGene Protein Over-expression Lysate for ARHGDIA | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for ARHGDIA | | OriGene 3'-UTR Clone for ARHGDIA | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGDIA | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for ARHGDIA | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for ARHGDIA | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for ARHGDIA | | OriGene Custom Protein Services for ARHGDIA | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat ARHGDIA | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing ARHGDIA | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGDIA | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat ARHGDIA | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat ARHGDIA | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat ARHGDIA |
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| | Antibodies & Assays for ARHGDIA
(RhoGDI alpha) |
| | | | Search Tocris compounds for ARHGDIA |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGDIA |
|  |  |  | | | | ThermoFisher Antibodies for ARHGDIA |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat ARHGDIA |
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