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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

ARHGDIA Gene

protein-coding   GIFtS: 67
GCID: GC17M079825

Rho GDP Dissociation Inhibitor (GDI) Alpha


(Previous symbol: GDIA1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Rho GDP Dissociation Inhibitor (GDI) Alpha1 2     NPHS82
GDIA11 2 3     RHOGDI2
Rho GDI 12 3     RHOGDI-12
Rho-GDI Alpha2 3     Rho GDP-Dissociation Inhibitor 12

External Ids:    HGNC: 6781   Entrez Gene: 3962   Ensembl: ENSG000001415227   OMIM: 6019255   UniProtKB: P525653   

Export aliases for ARHGDIA gene to outside databases

Previous GC identifers: GC17M079317 GC17M9I0128 GC17M080361 GC17M9I0504 GC17M9I7418 GC17M077419 GC17M075227


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for ARHGDIA Gene:
Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small
guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by
interaction with GDP dissociation inhibitors, such as ARHGDIA (Leffers et al., 1993 (PubMed 8262133)).(supplied
by OMIM, Jan 2009)

GeneCards Summary for ARHGDIA Gene: 
ARHGDIA (Rho GDP dissociation inhibitor (GDI) alpha) is a protein-coding gene. Diseases associated with ARHGDIA include oligodendroglioma, and inflammatory bowel disease, and among its related super-pathways are p75NTR regulates axonogenesis and Actin Nucleation and Branching. GO annotations related to this gene include Rho GDP-dissociation inhibitor activity and GTPase activator activity. An important paralog of this gene is ARHGDIG.

UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565
Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from
them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by
mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity)

Gene Wiki entry for ARHGDIA Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NT_010663.15  NC_018928.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the ARHGDIA gene promoter:
         AP-1   MyoD   CUTL1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): ARHGDIA promoter sequence
   Search SABiosciences Chromatin IP Primers for ARHGDIA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat ARHGDIA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.3   Ensembl cytogenetic band:  17q25.3   HGNC cytogenetic band: 17q25.3

ARHGDIA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
ARHGDIA gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17M079825:  view genomic region     (about GC identifiers)

Start:
79,825,597 bp from pter      End:
79,829,282 bp from pter
Size:
3,686 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565 (See protein sequence)
Recommended Name: Rho GDP-dissociation inhibitor 1  
Size: 204 amino acids; 23207 Da
Subunit: Monomer. Forms a heterodimer with RAC1. Interacts with PLXNB3 (By similarity). Interacts with FER.
Interacts with PSMD10 and RHOA; the interaction with PSMD10 increases ARHGDIA association with RHOA, leading to
ARHGDIA-mediated inactivation of RHOA and ROCK and prolonged AKT activation
Subcellular location: Cytoplasm
6/19 PDB 3D structures from and Proteopedia for ARHGDIA (see all 19):
1CC0 (3D)        1FSO (3D)        1FST (3D)        1FT0 (3D)        1FT3 (3D)        1HH4 (3D)    
Secondary accessions: A8MXW0 B2R5X1 B4DDD3 B4DUV9 Q6IBM5
Alternative splicing: 2 isoforms:  P52565-1   P52565-2   

Explore the universe of human proteins at neXtProt for ARHGDIA: NX_P52565

Explore proteomics data for ARHGDIA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P52565

  • ARHGDIA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    ARHGDIA Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001172006.1  NP_001172007.1  NP_004300.1  

    ENSEMBL proteins: 
     ENSP00000269321   ENSP00000383556   ENSP00000463939   ENSP00000441348   ENSP00000464205  
     ENSP00000462960   ENSP00000461956   ENSP00000462209   ENSP00000463530   ENSP00000462323  
    Reactome Protein details: P52565
    Human Recombinant Protein Products for ARHGDIA: 
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    Novus Biologicals ARHGDIA Proteins
    Novus Biologicals ARHGDIA Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for ARHGDIA
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001772immunological synapse IEA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol TAS--
    GO:0005856cytoskeleton TAS16130169

    ARHGDIA for ontologies           About GeneDecksing



    ARHGDIA Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR014756 Ig_E-set
     IPR024792 RhoGDI_domain
     IPR000406 Rho_GDI

    Graphical View of Domain Structure for InterPro Entry P52565

    ProtoNet protein and cluster: P52565

    1 Blocks protein domain: IPB000406 RHO protein GDP dissociation inhibitor signature

    UniProtKB/Swiss-Prot: GDIR1_HUMAN, P52565
    Similarity: Belongs to the Rho GDI family


    ARHGDIA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: GDIR1_HUMAN, P52565
    Function: Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from
    them, and the subsequent binding of GTP to them. In glioma cells, inhibits cell migration and invasion by
    mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1 (By similarity)

         Genatlas biochemistry entry for ARHGDIA:
    Rho GDP-dissociation factor inhibitor (GDI) alpha,aplysia related

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005094Rho GDP-dissociation inhibitor activity IEA--
    GO:0005096GTPase activator activity IEA--
    GO:0005515protein binding IPI10489445
         
    ARHGDIA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for ARHGDIA:
     Decreased focal adhesion (FA)   Increased cell death HMECs cel 

         10 MGI mutant phenotypes (inferred from 1 allele(MGI details for Arhgdia):
     behavior/neurological  cardiovascular system  cellular  endocrine/exocrine gland  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  renal/urinary system  reproductive system 

    ARHGDIA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Arhgdiatm1Ytk for ARHGDIA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for ARHGDIA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for ARHGDIA

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for ARHGDIA 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for ARHGDIA 

    miRNA
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    miRTarBase miRNAs that target ARHGDIA:
    hsa-mir-16 (MIRT001479), hsa-mir-151-5p (MIRT004486)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat ARHGDIA
    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGDIA (see all 29):
    hsa-miR-3910 hsa-miR-429 hsa-miR-15a hsa-miR-1271 hsa-miR-486-3p hsa-miR-650 hsa-miR-124 hsa-miR-9
    SwitchGear 3'UTR luciferase reporter plasmidARHGDIA 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for ARHGDIA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for ARHGDIA About   (see all 26)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Axonal growth inhibition (RHOA activation)
    Axonal growth inhibition (RHOA activation)0.90
    p75NTR regulates axonogenesis0.90
    2Actin Nucleation by ARP-WASP Complex
    Actin Nucleation by ARP-WASP Complex0.66
    RhoA Pathway0.35
    3Rho GTPase cycle
    Signaling by Rho GTPases1.00
    Rho GTPase cycle1.00
    4CDC42 signaling events
    RAC1 signaling pathway0.34
    CDC42 signaling events0.34
    5G-protein signaling Regulation of RAC1 activity
    G-protein signaling Regulation of RAC1 activity0.88

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/7 EMD Millipore Pathways for ARHGDIA (see all 7)
        G-protein signaling Regulation of CDC42 activity
    Signal transduction Calcium signaling
    G-protein signaling Rac2 regulation pathway
    G-protein signaling RhoB regulation pathway
    Development MAG-dependent inhibition of neurite outgrowth

    5/6 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for ARHGDIA (see all 6)
        RhoA Pathway
    Actin-Based Motility by Rho Family GTPases
    RhoGDI Pathway
    Rho Family GTPases
    Actin Nucleation by ARP-WASP Complex

    1 Cell Signaling Technology (CST) Pathway for ARHGDIA
        Cytoskeletal Signaling

    5/7 GeneGo (Thomson Reuters) Pathways for ARHGDIA (see all 7)
        G-protein signaling Regulation of RAC1 activity
    G-protein signaling Rac2 regulation pathway
    G-protein signaling RhoB regulation pathway
    G-protein signaling Regulation of CDC42 activity
    G-protein signaling RhoA regulation pathway

    5/6 BioSystems Pathways for ARHGDIA (see all 6)
        CDC42 signaling events
    p75(NTR)-mediated signaling
    Regulation of RhoA activity
    Regulation of CDC42 activity
    RAC1 signaling pathway


    5/8        Reactome Pathways for ARHGDIA (see all 8)
        Signaling by Rho GTPases
    Axonal growth inhibition (RHOA activation)
    p75NTR regulates axonogenesis
    Axonal growth stimulation
    Rho GTPase cycle


    2         Kegg Pathways  (Kegg details for ARHGDIA):
        Neurotrophin signaling pathway
    Vasopressin-regulated water reabsorption


    ARHGDIA for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for ARHGDIA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/160 Interacting proteins for ARHGDIA (P525651, 2, 3 ENSP000002693214) via UniProtKB, MINT, STRING, and/or I2D (see all 160)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RDXP352412, 3, ENSP000003428304MINT-18849 MINT-18848 I2D: score=4 STRING: ENSP00000342830
    CDKN1BP465272, 3, ENSP000002288724MINT-63858 I2D: score=5 STRING: ENSP00000228872
    FEN1P397482, 3, ENSP000003054804MINT-63857 I2D: score=5 STRING: ENSP00000305480
    JUPP149232, 3, ENSP000003111134MINT-63856 I2D: score=5 STRING: ENSP00000311113
    RAC3P607632, 3, ENSP000003042834MINT-8267929 I2D: score=3 STRING: ENSP00000304283
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006928cellular component movement TAS16130169
    GO:0007162negative regulation of cell adhesion TAS8262133
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0007266Rho protein signal transduction IEA--
    GO:0032880regulation of protein localization IEA--

    ARHGDIA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    ARHGDIA for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for ARHGDIA (GDIR1)

    2 HMDB Compounds for ARHGDIA    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine diphosphate5'-GDP (see all 10)146-91-8--
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    2 Novoseek inferred chemical compound relationships for ARHGDIA gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gdp 68.8 3 11285260 (2), 10716190 (1)
    gtp 63.8 4 10716190 (4)

    Search CenterWatch for drugs/clinical trials and news about ARHGDIA / GDIR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for ARHGDIA gene (3 alternative transcripts): 
    NM_001185077.1  NM_001185078.1  NM_004309.4  

    Unigene Cluster for ARHGDIA:

    Rho GDP dissociation inhibitor (GDI) alpha
    Hs.159161  [show with all ESTs]
    Unigene Representative Sequence: NM_001185077
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000582520 ENST00000269321(uc021uff.1 uc002kbq.3 uc021ufg.1 uc010dig.2)
    ENST00000400721 ENST00000584461 ENST00000541078 ENST00000580685 ENST00000579121
    ENST00000581876 ENST00000583868 ENST00000582984 ENST00000580033 ENST00000583791
    ENST00000578351 ENST00000583111 ENST00000584397 ENST00000583499 ENST00000582309

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    8/29 QIAGEN miScript miRNA Assays for microRNAs that regulate ARHGDIA (see all 29):
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    Additional mRNA sequence: 

    AF498926.1 AK293147.1 AK300816.1 AK312347.1 BC005851.2 BC005875.2 BC007630.1 BC008701.3 
    BC009759.2 BC013846.1 BC016031.1 BC016185.1 BC024258.1 BC027730.2 BC028333.1 BC075827.1 
    BC106044.1 BT006884.1 CR456777.1 D13989.1 M97579.1 X69550.1 

    24/53 DOTS entries (see all 53):

    DT.97856243  DT.91684644  DT.92471322  DT.100695007  DT.100767630  DT.97856170  DT.100694962  DT.95337225 
    DT.120995517  DT.95110686  DT.100039713  DT.100039717  DT.100039702  DT.120995317  DT.100694992  DT.100694978 
    DT.100694994  DT.100637405  DT.100637925  DT.100694986  DT.120995363  DT.100637549  DT.100694993  DT.100695003 

    24/367 AceView cDNA sequences (see all 367):

    AI368502 AI936667 AA578542 AA378122 F07681 BM466416 BM550876 BG420784 
    BG333610 AA327301 BM557147 BM820017 AL551201 AI083713 AI584101 BQ681446 
    BM819874 CB528621 BU196600 AI687437 AW575184 T28915 BC007630 BU538655 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for ARHGDIA (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h ^ 8a · 8b ^ 9
    SP1:                          -                                         -           -                                                                     
    SP2:                                                                    -           -                                                                     
    SP3:                                                                    -           -                       -     -     -     -     -     -               
    SP4:                          -           -     -     -                 -           -                                                                     
    SP5:                          -                                         -           -                                                                     


    ECgene alternative splicing isoforms for ARHGDIA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    ARHGDIA expression in normal human tissues (normalized intensities)      ARHGDIA embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCCTCCCC
    ARHGDIA Expression
    About this image


    ARHGDIA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/36 selected tissues (see all 36) fully expand
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Epithelium (Reproductive System)    fully expand to see all 5 entries
             vagina ; squamous epithelial cells   
     
     Blood (Hematopoietic System)    fully expand to see all 4 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             neutrophils   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   

    See ARHGDIA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for ARHGDIA

    SOURCE GeneReport for Unigene cluster: Hs.159161
        SABiosciences Expression via Pathway-Focused PCR Array including ARHGDIA: 
              Cell Motility in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for ARHGDIA gene from 10/22 species (see all 22)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Arhgdia1 , 5 Rho GDP dissociation inhibitor (GDI) alpha1, 5 88.4(n)1
    97.06(a)1
      11 (84.29 cM)5
    1926621  NM_133796.71  NP_598557.31 
     1205781045 
    chicken
    (Gallus gallus)
    Aves ARHGDIA1 Rho GDP dissociation inhibitor (GDI) alpha 83.5(n)
    91.18(a)
      769231  NM_001080871.1  NP_001074340.1 
    lizard
    (Anolis carolinensis)
    Reptilia ARHGDIA6
    Uncharacterized protein
    87(a)
    1 ↔ 1
    2(118584879-118588892)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.139782 Xenopus laevis transcribed sequence with moderate similarity more 74.34(n)    CA791691.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufa96g112 Danio rerio cDNA clone MGC55554 IMAGE2642774, complete more 80.15(n)    BC063968.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta RhoGDI1 , 3 Rho GDP-dissociation inhibitor3
    CG7823-PA1
    52(a)3
    57.48(n)1
    51.89(a)1
      76D53
    401791  NM_140905.21  NP_649162.11 
    worm
    (Caenorhabditis elegans)
    Secernentea rhi-11 , 3 rho GDP dissociation inhibitor3
    Protein RHI-11
    39(a)3
    50.09(n)1
    40.33(a)1
      X(4543798-4546035)3
    1807211  NM_076373.41  NP_508774.11 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes RDI1(YDL135C)4
    RDI11
    Rho GDP dissociation inhibitor involved in the localization more4
    Rdi1p1
    45.51(n)1
    41.01(a)1
      4(219288-218680)4
    8514201, 4  NP_010146.11, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons SCN11 Rho GDP-dissociation inhibitor 1 48.48(n)
    39.39(a)
      819979  NM_111667.3  NP_187445.1 
    rice
    (Oryza sativa)
    Liliopsida Os06g03183001 hypothetical protein 53.87(n)
    39.9(a)
      4340881  NM_001064037.1  NP_001057502.1 


    ENSEMBL Gene Tree for ARHGDIA (if available)
    TreeFam Gene Tree for ARHGDIA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for ARHGDIA gene
    ARHGDIG2  ARHGDIB2  
    2 SIMAP similar genes for ARHGDIA using alignment to 6 protein entries:     GDIR1_HUMAN (see all proteins):
    ARHGDIG    ARHGDIB

    ARHGDIA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/187 SNPs in ARHGDIA are shown (see all 187)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1378699621,2
    --79825197(+) TTGGGA/GTCCAG 3 -- int10--------
    rs1424754851,2
    --79825244(+) CACCTC/TCAAGC 3 -- int10--------
    rs1908623011,2
    --79825296(+) CTACAC/TAAGCC 3 -- int10--------
    rs1459583391,2
    C--79825308(+) GGCCCA/GTCTTC 3 -- int10--------
    rs1134079531,2
    C,F--79825332(+) AAGGAG/CGGGCA 3 -- int11Minor allele frequency- C:0.50NA 2
    rs1419700461,2
    --79825578(+) AGCCAA/CGCAGC 3 -- int10--------
    rs1506639341,2
    --79825585(+) CAGCAA/GACACC 3 -- int10--------
    rs1837152871,2
    --79825631(+) AAAAGA/CAGCAG 3 -- ut310--------
    rs1881919541,2
    --79825729(+) GTGTGC/TACTTG 3 -- ut310--------
    rs1929566741,2
    --79825743(+) CCTTGG/TTTGTT 3 -- ut310--------

    HapMap Linkage Disequilibrium report for ARHGDIA (79825597 - 79829282 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/16 variations for ARHGDIA (see all 16):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv909134CNV Loss21882294
    dgv3341n71CNV Loss21882294
    dgv3333n71CNV Loss21882294
    nsv833569CNV Loss17160897
    dgv3340n71CNV Loss21882294
    dgv3332n71CNV Loss21882294
    dgv3338n71CNV Loss21882294
    dgv3337n71CNV Loss21882294
    dgv3339n71CNV Loss21882294
    dgv3330n71CNV Loss21882294


    Human Gene Mutation Database (HGMD): ARHGDIA
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for ARHGDIA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601925    OMIM disorders: --

    9 diseases for ARHGDIA:    About MalaCards
    oligodendroglioma    inflammatory bowel disease    schizophrenia    colon cancer
    colorectal cancer    endotheliitis    prostate cancer    breast cancer
    prostatitis


    ARHGDIA for disorders           About GeneDecksing


    Export disorders for ARHGDIA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for ARHGDIA gene, integrated from 9 sources (see all 104):
    (articles sorted by number of sources associating them with ARHGDIA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Gankyrin plays an essential role in Ras-induced tumor igenesis through regulation of the RhoA/ROCK pathway in mammalian cells. (PubMed id 20628200)1, 2 Man J.H....Zhang X.M. (2010)
    2. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1, 2 Kim S.C.... Zhao Y. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. A somatic cell hybrid panel for distal 17q: GDIA1 maps to 17q25.3. (PubMed id 9186513)1, 3 Wagner T....Scherer G. (1997)
    5. A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm. (PubMed id 9195882)1, 2 Keep N.H.... Roberts G.C.K. (1997)
    6. Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton. (PubMed id 8262133)1, 2 Leffers H.... Celis J.E. (1993)
    7. Identification of a novel prenyl and palmitoyl modific ation at the CaaX motif of Cdc42 that regulates RhoGDI binding. (PubMed id 23358418)1 Nishimura A. and Linder M.E. (2013)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. Knockdown of RhoGDIa induces apoptosis and increases l ung cancer cell chemosensitivity to paclitaxel. (PubMed id 22668020)1 Rong F....Tao M. (2012)
    10. Proteome-wide identification of ubiquitylation sites b y conjugation of engineered lysine-less ubiquitin. (PubMed id 22053931)1 Oshikawa K....Nakayama K.I. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 396 HGNC: 678 AceView: ARHGDIA.1 Ensembl:ENSG00000141522 euGenes: HUgn396
    ECgene: ARHGDIA Kegg: 396 H-InvDB: ARHGDIA

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for ARHGDIA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for ARHGDIA gene:
    Search GeneIP for patents involving ARHGDIA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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